How to take strepsils throat lozenges: instructions, indications for use, analogues. Instructions for use lollipops strepsils intensive Strepsils action

Strepsils is a combination drug that has antimicrobial, analgesic and antifungal effects. It first went on sale in 1958. Today, Strepsils spray is one of the most popular and effective medicines for treating sore throats.

In this article, we will consider why doctors prescribe Strepsils, including instructions for use, analogues and prices for this drug in pharmacies. REAL REVIEWS people who have already used Strepsils can be read in the comments.

Composition and form of release

Lozenges: red round tablets with a predominant anise odor with the letter S on both sides of the tablet. A white coating, uneven coloring, the presence of air bubbles in the caramel mass and a slight unevenness of the edges are allowed.

• One tablet contains active substances: 2,4-dichlorobenzyl alcohol - 1.2 mg, amylmetacresol - 0.6 mg.

pharmachologic effect: antiseptic action.

Indications for use

Symptomatic treatment of pain in oral cavity, throat, larynx with infectious inflammatory diseases: tonsillitis, pharyngitis, laryngitis (including professional ones - among teachers, announcers, workers in the chemical and coal industries), hoarseness, inflammation of the oral mucosa and gums (aphthous stomatitis, gingivitis, thrush).

pharmachologic effect

The action of the active substances of the Strepsils preparation is aimed at destroying the bacterial cell membrane, as well as dehydrating the cells of microorganisms, due to such activity, a bactericidal and bacteriostatic effect is provided.

• The drug has a fungicidal effect against fungi of the genus Candida, which is an important factor in the treatment of inflammatory diseases of the throat and pharynx aggravated by fungal infections.

To action medicinal product Strepsils are also sensitive: Streptococcus spp., Staphylococcus epidermidis, Staphylococcus pyogenes, Staphylococcus salivarius, Staphylococcus aureus, Klebsiella aerogenes, Proteus spp., Diplococcus pneumoniae Aerobacter spp, etc. aerobic and anaerobic microorganisms.

Instructions for use

According to the instructions for use, Strepsils should be sucked until the tablet is completely dissolved. It is not recommended to use more than twelve Strepsils lozenges within twenty-four hours.

• Adults and children over six years of age are advised to take one lozenge every two to three hours when the first symptoms of inflammation appear in the mouth or throat.

The duration of the course of therapy is determined by the doctor in each case individually, depending on clinical picture, the severity of the disease and its course.

Contraindications

Strepsils is not prescribed for children under 5 years of age. Lollipops are prohibited in case of intolerance to the components. For patients suffering from spasms in the bronchi, the use of a spray is not recommended. With diabetes, it is better to choose tablets without sugar.

Side effects

IN rare cases possible occurrence of allergic phenomena.

Pregnancy and lactation

The use of the drug during pregnancy and during breastfeeding possible only under medical supervision.

Analogues

Structural analogues for the active substance:

• Agisept;
• Astracept;
• Gorpils;
• Koldakt Lorpils;
• Rinza Lorcept;
• Suprima ENT;
• Terasil.

Attention: the use of analogues must be agreed with the attending physician.

Prices

The average price of STREPSILS in pharmacies (Moscow) is 170-280 rubles, depending on the form of release.

1. Svetlana

   Ambiguous feeling. Since childhood, I often get sick, and sore throat is a constant symptom. Strange, but doctors constantly attribute it to Strepsils. Yes, it is delicious, but it can be called medicinal with a stretch. One of its disadvantages is that it is very expensive, and, as for me, the price-quality ratio is very bad. Last winter, I decided not to spend any more money and instead of strepsils I bought the usual Holes lollipops.

   They feel even more mentholic than Strepsils, they relieve pain perfectly, and the throat itself was treated by rinsing the usual furacilin. As a result, strepsils are expensive and impractical, you can suck it as much as you like, but this is unlikely to help. The only really working variety of strepsils is = Strepsils Plus (with anesthetic), but again, it is very expensive compared to other drugs.

2. Nika

   My husband went to the pharmacy three hours ago for my throat, they slipped him this strepsils spray there. They immediately sprayed, at first there was nothing, an hour later my throat hurt again, they sprayed again.

   It's been three hours now since the first squirt, and I'll tell you this: I'm physically ill!!! The throat is all pershit and maybe even the temperature has risen, the head is spinning !!! Before using this strepsils, I just had a sore throat for one day, because I drank cold milk. And now I feel so bad that I don't know what to do. I also read that it contains alcohol. It is not at all clear what kind of drug this is.

3. Lena

Tablets for resorption honey-lemon - 1 tab.:

• active substances: 2,4-dichlorobenzyl alcohol 1.2 mg, amylmetacresol 0.6 mg;
• excipients: tartaric acid 26 mg, honey 125.6 mg, peppermint leaf oil 0.62 mg, lemon oil (terpene-free) 2.03 mg, quinoline yellow dye (E104), 0.099 mg, sugar syrup [sucrose, water], liquid dextrose [dextrose, oligo- and polysaccharides] to obtain a tablet weighing 2.6 g.

Tablets for resorption menthol-eucalyptus. 4, 6, 8 or 12 tab. in blister (PVC/PVDC/aluminium). 1, 2 or 3 bl. placed in a cardboard box, a metal box, in a bag of laminated packaging foil or fixed in a cardboard cover.

10 tab. in a polypropylene tube with a polypropylene cap that provides control of the first opening, with a desiccant.

Description of the dosage form

Blue round tablets with the letter "S" on both sides of the tablet. A white coating, uneven coloring, the presence of air bubbles in the caramel mass and a slight unevenness of the edges are allowed.

Characteristic

Combined antimicrobial drug.

pharmachologic effect

Antiseptic.

Pharmacodynamics

The drug has an antiseptic effect, is active against a wide range of gram-positive and gram-negative microorganisms in vitro, and has an antimycotic effect. Essential oils of menthol and eucalyptus relieve nasal congestion.

Indications for use Strepsils

Symptomatic treatment of pain in the oral cavity, throat, larynx in infectious and inflammatory diseases: tonsillitis, pharyngitis, laryngitis (including professional ones - in teachers, announcers, workers in the chemical and coal industries), hoarseness, inflammation of the oral mucosa and gums (aphthous stomatitis, gingivitis, thrush). Essential oils of menthol and eucalyptus relieve nasal congestion.

Contraindications to the use of Strepsils

• hypersensitivity to the components of the drug;
• childhood(up to 5 years).

With caution: pregnancy; breastfeeding period; bronchial asthma.

Strepsils Use during pregnancy and children

The use of the drug during pregnancy and during breastfeeding is possible only under the supervision of a physician.

Strepsils side effects

Allergic reactions (rash; burning or tingling sensation in the throat, swelling of the throat).

In the event of unusual reactions, you should consult your doctor about the advisability of further use of the drug.

drug interaction

Clinically significant interactions with other drugs have not been identified. Perhaps the simultaneous use of the drug with other local antimicrobial agents.

Dosage Strepsils

Overdose

Symptoms: Overdose is unlikely. Possible overdose can lead to gastrointestinal discomfort (nausea)

Treatment: symptomatic, under medical supervision.

Precautionary measures

Do not use the drug in the presence of increased individual sensitivity to any component that is part of the drug. Sick diabetes should take into account that each tablet contains about 2.6 g of sugar.

Influence on the ability to drive mechanisms and a car. The drug does not affect the ability to drive vehicles and mechanisms, as well as other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Strepsils (Strepsils)

Composition

1 lozenge Strepsils original contains:
Amylmetacreazole - 0.6 mg;

Auxiliary substances, including essential oils of peppermint and anise, glucose, sucrose, levomenthol.

1 lozenge Strepsils with vitamin C contains:
Amylmetacreazole - 0.6 mg;
2,4-dichlorobenzyl alcohol - 1.2 mg;
Ascorbic acid - 100 mg;
Auxiliary substances, including essential oils of anise and sweet orange, glucose, sucrose, levomenthol.

1 lozenge Strepsils with menthol and eucalyptus contains:
Amylmetacreazole - 0.6 mg;
2,4-dichlorobenzyl alcohol - 1.2 mg;
Auxiliary substances, including eucalyptus essential oil, glucose, sucrose.

1 lozenge Strepsils without sugar with lemon and herbs contains:
Amylmetacreazole - 0.6 mg;
2,4-dichlorobenzyl alcohol - 1.2 mg;
Auxiliary substances, including rosemary essential oil.

1 lozenge Strepsils with honey and lemon contains:
Amylmetacreazole - 0.6 mg;
2,4-dichlorobenzyl alcohol - 1.2 mg;
Auxiliary substances, including honey, essential oils of peppermint and lemon, glucose, sucrose.

pharmachologic effect

Combined antibacterial and fungicidal drug for use in dentistry and ENT practice. The drug contains 2 main antimicrobial components - amylmethacreazole and 2,4-dichlorobenzyl alcohol. These substances have a wide spectrum of antimicrobial activity, including effective against gram-positive and gram-negative bacteria. The drug has a bactericidal and bacteriostatic effect due to the destruction of the cell membrane of bacteria. In addition, 2,4-dichlorobenzyl alcohol dehydrates the cells of microorganisms, which leads to their death. Streptococcus spp., Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus pyogenes, Staphylococcus salivarius, Diplococcus pneumoniae, Klebsiella aerogenes, Proteus spp., Aerobacter spp and other aerobic and anaerobic microorganisms are sensitive to the action of the drug. The drug is also active against fungi of the genus Candida, which is an important selection criterion in the treatment of inflammatory diseases aggravated by a fungal infection.

On the pharmaceutical market, Strepsils is presented in five versions. In each of the options, the antibacterial action of amylmethacreazole and 2,4-dichlorobenzyl alcohol is supplemented with natural ingredients for a more effective therapeutic effect in case of various types diseases of the oral cavity and pharynx.

Strepsils The original is the classic version of Strepsils, which, in addition to antibacterial components, includes a complex of essential oils of anise and peppermint. These essential oils have a softening effect on the mucous membrane due to a reflex increase in secretion. salivary glands. An increase in the amount of saliva also has an antibacterial effect, since saliva contains natural antibiotic lysozyme. In addition, when it comes into contact with the mucous membrane, essential oils cause hyperemia in this area, which leads to an improvement in microcirculation and accelerates the healing process.

Strepsils with vitamin C - in addition to antibacterial components, it contains ascorbic acid (vitamin C) and helps to increase immunity, reduce capillary permeability, and has anti-inflammatory and anti-allergic effects. Ascorbic acid inhibits the synthesis of prostaglandins and histamine, helping to reduce swelling and inflammation.

Strepsils with menthol and eucalyptus - a combination of menthol and essential oil Eucalyptus has antibacterial, anti-inflammatory, analgesic and some expectorant effects. In addition, pairs of menthol and eucalyptus have a vasoconstrictive effect, thus removing swelling of the nasal mucosa and facilitating nasal breathing.

Strepsils without sugar with lemon and herbs - has a pleasant taste, has a softening effect on the mucous membrane of the pharynx, has an antimicrobial and expectorant effect, eliminates inflammation and hyperemia. It does not contain sugar, so it is recommended for children, people with diabetes and limiting sugar intake. In this case, the drug does not contribute to the development of caries.

Strepsils with honey and lemon - has a softening, anti-inflammatory effect, increases the body's ability to resist infections. Honey has a bactericidal effect, improves metabolic processes removing toxins from the body.

The pharmacokinetics of the drug has not been studied.

Indications for use

The drug is used in acute and chronic inflammatory diseases of the oral cavity and pharynx caused by microorganisms sensitive to the drug.
It is used in the treatment of such diseases: laryngitis, pharyngitis, tonsillitis, stomatitis, aphthae, periodontal disease. The drug is also used in complex treatment sore throats.
They are used in dentistry and ENT practice after surgical interventions, for the prevention of infection and the development of an inflammatory process, in particular, they are used after tooth extraction, tonsillectomy.

Mode of application

Adults and children over 5 years of age are usually prescribed 1 tablet with an interval of 2-3 hours. The maximum daily dose is 8 tablets. The drug is recommended to be taken after meals or 30 minutes before. Tablets must be sucked until completely dissolved.

Side effects

Perhaps the development of allergic reactions. It is extremely rare that a change in taste sensations is possible. Other side effects should not be expected, since the components of the drug are not absorbed into the systemic circulation.

Contraindications

Increased individual sensitivity to the components of the drug.
For Strepsils with honey and lemon - hypersensitivity to bee products.
Not recommended for children under 5 years of age.
The drug Strepsils (except Strepsils without sugar with lemon and herbs) is prescribed with caution to patients suffering from diabetes and limiting sugar intake, it should be borne in mind that one lozenge contains 2.6 g of sugar.

Pregnancy

There are no contraindications for the use of the drug during pregnancy and lactation. The components of the drug topical application do not have teratogenic, mutagenic and embryotoxic effects. When using the drug according to the instructions, the components of the drug are not excreted in breast milk.

Overdose

An overdose of the drug may cause discomfort from the side gastrointestinal tract. In case of overdose, gastric lavage is indicated and symptomatic treatment. There is no specific antidote.

Release form

Strepsils lozenges original 8 pieces in a blister, 3 blisters in a carton.
Strepsils lozenges with vitamin C, 8 pieces in a blister, 3 blisters in a carton.
Strepsils lozenges with menthol and eucalyptus, 8 pieces in a blister, 3 blisters in a carton.
Strepsils lozenges without sugar with lemon and herbs, 8 pieces in a blister, 2 blisters in a carton.
Strepsils lozenges with honey and lemon, 8 pieces in a blister, 1 or 3 blisters in a carton.

Storage conditions

The drug should be stored in a dry place protected from direct sunlight at room temperature.
Shelf life - 3 years.

Nosological classification (ICD-10)

Candidal stomatitis (B37.0)

Acute pharyngitis (J02)

Acute tonsillitis (J03)

Acute laryngitis and tracheitis (J04)

One tablet contains active substances: 2,4-dichlorobenzyl alcohol - 1.2 mg, amylmetacresol - 0.6 mg.

Excipients:

lozenges: tartaric acid 26 mg, levomenthol (natural) 4.49 mg, peppermint leaf oil 0.48 mg, common anise seed oil 2.3 mg, crimson dye [Ponceau 4R] (Edicol CI 16255, E 124) 0.32 mg , dye azorubin (Edicol CI 14720, E 122) 0.05 mg, sugar syrup (sucrose, water), liquid dextrose [dextrose, oligo- and polysaccharides] (liquid glucose) to obtain a tablet weighing 2.6 g.

lozenges [honey-lemon]: tartaric acid 26 mg, honey 125.6 mg, peppermint leaf oil 0.62 mg, lemon oil (terpene-free) 2.03 mg, quinoline yellow dye (E 104) 0.099 mg, sugar syrup (sucrose, water), dextrose liquid [dextrose, oligo- and polysaccharides] (liquid glucose) to obtain a tablet weighing 2.6 g.

Description

Lozenges:

red round tablets with a predominant anise odor with the image of the letter S on both sides of the tablet. A white coating, uneven coloring, the presence of air bubbles in the caramel mass and a slight unevenness of the edges are allowed.

Lozenges [honey-lemon]:

yellow round tablets with the image of the letter S on both sides of the tablet. A white coating, uneven coloring, the presence of air bubbles in the caramel mass and a slight unevenness of the edges are allowed.

pharmachologic effect

2,4-dichlorobenzyl alcohol and amylmetacresol are antiseptics and have antibacterial, antifungal and antiviral properties. Amylmetacresol and 2,4-dichlorobenzyl alcohol also reversibly block pre-polarization-induced ion channels, similar to the action of local anesthetics. The combination of these active substances in one preparation leads to a synergistic antibacterial action and reduction of the combined dose in Strepsils tablets.

The antibacterial and antifungal activity of Strepsils has been demonstrated in in vitro and in vivo studies. Antiviral activity against enveloped viruses has also been demonstrated in vitro after contact with Strepsils tablets for 1 minute. The long history of the global use of Strepsils tablets has not demonstrated a decrease in their activity against various pathogenic agents, which suggests that resistance has not developed.

IN clinical research the analgesic effect of Strepsils was demonstrated in the form of reducing the soreness of the pharynx, relieving pain when swallowing, lasting from 5 minutes to 2 hours. Significantly greater symptom relief was observed with this drug for three days compared with non-drug treatment.

Strepsils with Honey and Lemon contains flavorings and honey that provide sensory stimulation while the tablet base acts on the sore throat.

Pharmacokinetics

Oral bioavailability studies conducted for Strepsils demonstrated a rapid release of 2,4-dichlorobenzyl alcohol and amylmethacresol in saliva, peaking at 3-4 minutes of tablet resorption. A doubling of saliva volume was observed within one minute and levels were maintained above baseline while the tablet was dissolving for about 6 minutes.

Measurable amounts of active substances were expectorated up to 20-30 minutes after dosing; the pure recovery of active substances indicates a long-term residue of them both on the oral mucosa and on the pharyngeal mucosa.

Scintigraphic studies of Strepsils with sugar demonstrated the gradual dissolution of the tablet with the deposition of dissolving substances on the oral and pharyngeal mucosa from 2 minutes after the start of tablet resorption and within 2 hours after resorption, providing long-term relief of irritation in the throat.

When administered orally, the acute toxicity of 2,4-dichlorobenzyl alcohol and amylmethacresol is negligible with a wide margin of safety, and toxicological studies of n^n^pvanide indicate that little kidney damage occurs at four times the standard dose.

In chronic toxicity studies in rats, an increase in kidney and liver weight was found after daily use oral doses of 200 and 400 mg/kg of 2,4-dichlorobenzyl alcohol (much higher than the daily dose). In addition, depending on the dose, damage to the gastric mucosa in the form of ulcerative erosions and necrosis was observed along with hyperplasia and hyperkeratosis of the epithelium.

Conducted in vitro and in vivo studies of the genotoxicity of amylmethacresol and 2,4-dichlorobenzyl alcohol did not reveal any potential genotoxic risk when used at recommended doses. Genotoxicity data and long-term clinical use have not shown a risk of carcinogenicity. An embryotoxicity study in rabbits and prospective safety studies in humans provide no evidence of possible teratogenic effects. Studies in rabbits using a dose 50 times higher than the standard dose did not reveal the effect of Strepsils on the course of pregnancy, fetal development, or the detection of malformations. There are no data available on effects on fertility or development after birth.

Indications for use

To alleviate the symptoms of infectious and inflammatory diseases of the oral cavity and pharynx.

Contraindications

Hypersensitivity to the components of the drug; children's age (up to 6 years).

Pregnancy and lactation

The safety of the use of Strepsils lozenges (honey-lemon) during pregnancy and lactation has not been established, but the drug is not considered dangerous.

Dosage and administration

For oral use.

It is used in adults and children over 6 years of age.

It is necessary to slowly dissolve in the mouth 1 tablet every 2-3 hours, but not more than 12 tablets within 24 hours.

The drug is not intended for children under 6 years of age.

Use by elderly patients: no dosage reduction is required.

In case of missing the next dose of the drug, it is recommended to take the dose in accordance with the prescribed dosing regimen, without doubling the amount of the drug.

Side effect"type="checkbox">

Side effect

Adverse reactions that may occur with short-term use of the drug are listed by frequency of occurrence in the following order:

Very common: >1/10

Common: > 1/100 to<1/10

Uncommon: > 1/1,000 to<1/100

Rare: > 1/10,000 to<1/1, 000

Very rarely:<1/10, 000

In each class of organs and systems, undesirable effects are presented in order of decreasing frequency.

With prolonged use of the drug, additional adverse reactions may occur.

From the side of the immune system

Hypersensitivity

From the side of the respiratory system, chest and mediastinum - Edema of the pharynx

From the gastrointestinal tract

Discomfort in the mouth (burning sensation in the mouth)

There may also appear: a burning sensation or tingling in the throat, a sensation of tingling of the oral mucosa, swelling of the oral mucosa, tongue pain, dyspepsia, nausea.

On the part of the skin and subcutaneous tissues - Rash.

In the event of unusual reactions, you should consult your doctor about the advisability of further use of the drug.

Overdose

Symptoms: Overdose is unlikely. A possible overdose can lead to discomfort from the gastrointestinal tract: nausea. Treatment: symptomatic under medical supervision.