Tizalud tablets: instructions for use. The use of muscle relaxant Tizalud: indications, instructions, reviews

"Tizalud" is a drug whose main goal is to eliminate seizures and reduce the number of spasms in skeletal muscles. The desired effect is achieved thanks to tizinidine, the main active substance of the medical preparation.

The composition of the drug

One tablet contains 2 or 4 mg of tizanidine. Excipients: sodium carboxymethyl starch, anhydrous lactose, magnesium, microcrystalline cellulose.

Medicinal properties

"Tizalud" is a muscle relaxant drug of central action. It effectively helps to eliminate acute muscle spasms, as well as spasms in spinal etiology. Also, this drug relieves inflammation and swelling of the affected joints.

Excreted "Tizalud" bile and urine.

Indications for use

The use of "Tizalud" is effective in such diseases and conditions:

  • Spasm of skeletal muscles, which was caused by damage to the vertebrae
  • Spasm in the cervical and lumbar regions
  • Pathologies of the spine, which are accompanied by acute pain
  • Multiple sclerosis, which causes a spastic condition of the skeletal muscles
  • Degenerative diseases of the spinal cord
  • Herniated disc
  • Osteoarthritis of the hip
  • Pain after surgery
  • hemiplegia
  • Myelopathy
  • Cerebral paralysis
  • Stroke
  • Circulatory disorder
  • Seizures.

Release form

The average price is from 120 to 150 rubles.

This drug is available in the form of tablets in a dosage of 2 and 4 mg. One package of "Tizalud" tablets contains 30 pcs. Odorless tablets.

Mode of application

Apply "Tizalud" is intended inside.

To relieve muscle spasm, you need to take 2 mg three times a day. In especially severe cases, the dose can be increased to 4 mg per day.

The total duration of therapy is determined by the attending physician, depending on the susceptibility of the organism, symptoms and severity of the disease.

During pregnancy and breastfeeding

"Tizalud" tablets should not be used during pregnancy, except in cases where the benefit to the expectant mother will be greater than the possible risks to the fetus.

However, if there is a need for treatment with "Tizalud" during lactation, because of which the child may suffer, then the question of stopping breastfeeding should be raised.

Since the drug is prohibited for use by pregnant women, you need to know other, safer ways to treat seizures, which you can read about in the article:.

Contraindications

The drug has such contraindications:

  • Age under 18
  • Pregnancy
  • lactation period
  • Severe liver disease
  • Individual intolerance to the components of the drug
  • The period after a stroke
  • Simultaneous therapy with the drug Ciprofloxacin.

Precautionary measures

It is necessary to take the drug with caution under such circumstances:

  • Old age (over 60 years old)
  • arterial hypotension;
  • Acute kidney failure
  • Deterioration of the liver.

Interaction with other drugs

This drug can not be combined with CYP1A2 isoenzyme inhibitors - antiarrhythmic drugs:

  • Cimetidine
  • Pefloxacin
  • Ticlopidin
  • Norfloxacin
  • Fluvoxamine
  • Amiodarone.

Also, the substance tizanidine cannot be combined with ethanol and antihypertensive drugs, as this increases the risk of bradycardia and increased blood pressure.

Tizanidine should not be taken with alcoholic beverages, as this may cause the patient to experience side effects.

Side effects

This drug may cause the following side effects:

  • In the nervous system:
    • Drowsiness or, conversely, loss of sleep
    • Dizziness and headaches
    • hallucinations
    • Seizures.
  • In the digestive system:
    • Diarrhea, nausea
    • Hepatitis
    • Constipation
    • Heartburn and dry mouth
    • Increased liver enzymes.
  • In the cardiovascular system:
    • A sharp drop in blood pressure
    • Collapse
    • Loss of consciousness
    • Arrhythmia or tachycardia
    • Bradycardia.
  • Other side effects:
    • Loss of strength, weakness and fatigue
    • Pain in the muscles
    • Violation of cerebral circulation.

Overdose

In case of an overdose, the patient may experience the following symptoms:

  • Nausea
  • Increase in blood pressure
  • convulsions
  • Heavy breathing
  • Nervousness and anxiety
  • Dizziness
  • hypotension
  • Drowsiness.

Terms and conditions of storage

The drug must be stored in a dry and dark place at a temperature of no more than 25 degrees.

Expiration date: 2 years from the production date indicated on the package.

Analogues

Tizalud has such medicinal analogues:

Novartis Pharma, Switzerland
Price from 200 to 230 rubles.

Main action: centrally acting muscle relaxant. Reduces spasticity in the patient, as well as convulsions. It is prescribed for chronic myelopathy, multiple sclerosis, paralysis and many other diseases. Release form: round white tablets packed in a foil blister.

pros

  • Effectively relieves muscle spasms
  • Helps relieve pain after surgery

Minuses

  • Contraindicated in renal failure
  • Not recommended for use in the elderly.

Polpharma, Poland
Price from 240 to 270 rubles.

Main action: centrally acting muscle relaxant. It is prescribed for neurological diseases. Ingredients: baclofen - 25 mg.

pros

  • Increases movement in affected joints
  • Absorbed quickly.

Minuses

  • Contraindicated in pregnancy
  • Not recommended for atherosclerosis.

« «

Teva Private, Hungary.
Price from 150 to 200 rubles.

Main action: centrally acting muscle relaxant. Reduces the tone of skeletal muscles and relieves spasm. It also reduces muscle resistance during movements and increases their contractions. Composition: tizanidine - 4 mg. Available in the form of white tablets. which on one side have a characteristic engraving "T2".

pros

  • Relieves pain from injuries of the spine and joints
  • Improves blood circulation

Minuses

  • Does not mix well with other drugs
  • Contraindicated in patients with renal insufficiency.

Tizalud tablets are a drug designed to relieve muscle spasms.

The drug has a wide range of contraindications and many side effects, so you need to take it in strict accordance with the instructions developed by the manufacturer and according to the prescriptions of doctors.

General characteristics of the drug

The release of the drug Tizalud is carried out by the Russian pharmaceutical company Veropharm. The drug is a white cylindrical tablet with beveled edges and a risk on one of the surfaces. Each of them contains 2 or 4 mg of the active ingredient. The manufacturer packs tablets of 10 pcs. in blister packs made of PVC and aluminum foil.

In pharmacies, the medicine is sold in cardboard packs, each of which contains 3 blisters with medicines and a leaflet with instructions for use.

Tizalud tablets can only be bought with a doctor's prescription. The price of the drug depends on the concentration of the active substance and varies between 120-190 rubles per standard pack. The drug must be stored in its original packaging at temperatures up to 25 ° C. It is important to ensure that it is not exposed to moisture and direct sunlight. Subject to the described conditions, the drug retains its pharmacological and organoleptic properties for 36 months. Unused expired tablets must be discarded.

Composition and pharmacological action

The main active ingredient in Tizalud is tizanidine hydrochloride. Once in the human body, this component stimulates the work of presynaptic α2-adrenergic receptors, inhibits the release of "excitatory" amino acids (glutamine, aspartic) and suppresses polysynaptic transmission of impulses at the level of spinal cord interneurons. Because of this, tizanidine hydrochloride:

  • eliminates muscle spasms;
  • relieves clonic convulsions;
  • reduces resistance to passive movements;
  • increases the strength of voluntary muscle contractions;
  • exhibits moderate analgesic properties.

Auxiliary components in the composition of the drug are anhydrous lactose, microcrystalline cellulose, stearic acid and aerosil.

Indications for appointment

The active ingredient of the drug acts as a centrally acting muscle relaxant, so the main indications for the use of Tizalud are:

  • spasticity skeletal muscles with multiple sclerosis, cerebral palsy, chronic myelopathy, degenerative processes in the tissues of the spinal cord and other neurological pathologies;
  • pain syndrome and muscle spasms that accompany the development of functional and static diseases of the spinal column (lumbar and cervical).

In addition, the drug is used to relieve muscle cramps that occur after surgery for osteoarthritis. hip joint and herniated disc.

Reception scheme

Tizalud is taken orally with a small amount of non-carbonated water. The tablets are swallowed whole, without chewing or dissolving. With painful muscle spasms, patients are prescribed 2-4 mg of the drug three times a day. In severe cases, the daily dose of the drug is increased by 2 mg.

In cases where Tizalud is prescribed to relieve skeletal muscle spasticity, a more complex dosing regimen is used. In the first week, patients take 2 mg of the drug three times a day. Then the daily dose of the drug is increased by 2-4 mg with an interval of 72-96 hours. Most patients are able to achieve optimal therapeutic effect when taking 12-24 mg of tizanidine hydrochloride per day.

Persons who have previously been diagnosed with renal failure are prescribed 2 mg of the drug per day. The initial dose is increased gradually, taking into account the tolerability of the drug and the effectiveness of therapy. First of all, the volume of the drug is increased, and only then - the frequency of administration.

With acute pain syndrome caused by muscle spasm, the drug is taken for 2-3 weeks. At chronic pain the patient may require a longer course of therapy (from several months to a year). If necessary, the doctor can adjust the treatment regimen, taking into account the dynamics of pain and muscle-tonic manifestations of the disease.

Taking more than 36 mg of tizanidine hydrochloride per day can cause dizziness, nausea, drowsiness, vomiting, increased anxiety, disturbances in work respiratory system, reduction blood pressure, constriction of the pupils and falling into a coma.

If one or more signs of an overdose are detected, it is necessary to cancel the medicine, rinse the stomach, take diuretic drugs and activated charcoal. In addition, you should consult a doctor as soon as possible.

Side effects

Most patients tolerate treatment with Tizalud with ease. Undesirable effects of the drug are rare. These include:

  • daytime sleepiness or insomnia at night;
  • general weakness, increased fatigue;
  • a significant decrease in blood pressure;
  • dizziness;
  • violation of sinus rhythm (bradycardia);
  • nausea;
  • hallucinations;
  • muscle weakness;
  • dry mouth, constant thirst;
  • increased activity of hepatic transaminases;
  • digestive disorders;
  • acute inflammation of the liver.

The components present in the composition of Tizalud can provoke the development of allergic reactions in the form of urticaria, skin itching, rashes, swelling of facial tissues, etc.

Contraindications for use

Tizalud is not suitable for all patients who complain of muscle spasms. Most often, the individual intolerance to tizanidine hydrochloride and auxiliary components of the drug becomes the basis for refusing to use this drug. Contraindications to the appointment of tablets are:

  • age under 18;
  • simultaneous treatment with fluvoxamine;
  • severe functional failures in the liver;
  • pregnancy;
  • breastfeeding period.

In patients taking Tizalud, the speed of psychomotor reactions and concentration of attention may decrease, therefore the manufacturer recommends that persons undergoing therapy with this medication temporarily stop driving and other complex technical devices.

Drug analogues

In today's market pharmaceuticals you can find many analogues of the drug Tizalud for the active ingredient and medicinal properties. These include:

  • tablets Tizanil, Lioresal, Tolperison, Mydocalm, Baclofen, Sirdalud, Tolperil-Health, Myolastan, Tizanidin and Baclosan;
  • prolonged action capsules Miorix;
  • solutions for intramuscular injection Meloflex, Muskomed, Miaxil and Midostad Combi.

All centrally acting muscle relaxants included in this group have a lot of features in use, harmful effects, absolute and relative contraindications, therefore, they can be used as an alternative to Tizalud tablets only with the consent of the attending physician.

What is the drug "Tizalud"? Instructions for use, reviews and features of this medication will be discussed below. You will also find out if the tool in question has side effects and prohibitions on use.

Form, packaging of the drug, composition

In what form is the drug "Tizalud" produced? Patient reviews report that this medication is sold in tablet form, which may include 4 or 2 mg of the active ingredient tizanidine.

In addition to the mentioned substance, the composition of the drug in question includes such additional elements as anhydrous lactose, sodium carboxymethyl starch, magnesium stearate and microcrystalline cellulose.

Tablets "Tizalud", reviews of which are presented below, are packed in contour cells, which are placed in cardboard boxes.

Pharmacology of the oral remedy

What is remarkable about such a drug as "Tizalud"? Instructions, reviews of experts indicate that this remedy is a muscle relaxant that exhibits a central effect.

What changes occur in the human body after taking the drug in question? The effect of its active component on alpha2-adrenergic receptors (presynaptic) contributes to the inhibition of the release of excitatory amino acids from the intermediate spinal neurons, which ultimately leads to a slow polysynaptic propagation of the impulse in the spinal cord. Due to this mechanism of action, muscle tissue the patient is significantly reduced.

Features of the drug

What other properties are characteristic of the drug "Tizalud"? The reviews claim that, in addition to the muscle relaxant effect, tizanidine has a moderate analgesic effect.

According to the instructions, these tablets are very effective for chronic spasms of spinal and cerebral origin, as well as painful and acute spasms of muscle tissue.

Taking this medication significantly reduces muscle spasticity and clonic convulsions, resulting in reduced resistance to passive movements, and also increases the likelihood of active actions.

Indications for taking medication

Under what conditions of the patient does such a remedy as "Tizalud" work most effectively? Reviews of the drug indicate that this medication quite well and quickly eliminates muscle spasms that are observed in pathologies of the spinal column and are accompanied by pain. Thus, the agent in question is often prescribed for:

  • spondylosis;
  • hemiplegia;
  • osteochondrosis;
  • syringomyelia;
  • lumbar and cervical syndromes.

Are there any other indications for the drug "Tizalud"? Reviews of experts say that this remedy is actively used in the postoperative period after intervention for intervertebral hernias and osteoarthritis of the femoral joint. Also, the tablets in question help well with pain and spasticity of muscles provoked by neurological diseases, including chronic myelopathy, cerebral palsy, degenerative changes in the spinal cord, convulsions of central origin, cerebrovascular accident, multiple sclerosis, stroke, trauma of the skull and brain.

Prohibitions on the use of oral medication

What contraindications should patients be aware of before taking Tizalud tablets? Instructions, reviews report that there are not very many prohibitions on the use of this medicine. These include only the following conditions:

  • hypersensitivity of the patient to tizanidine, as well as other constituent elements of the drug;
  • concurrent use of drugs such as Ciprofloxacin and Fluvoxamine, as well as other potent inhibitors of the CYP1A2 isoenzyme.
  • liver pathology (severe);
  • period of gestation;
  • minor age;
  • breastfeeding period.

Cautious drug prescribing

With caution, the medication in question should be prescribed in the following cases:

  • with renal failure;
  • over the age of 65-68 years;
  • with bradycardia;
  • with arterial hypotension;
  • when used together with oral contraceptives.

The drug "Tizalud" (tablets): instructions for use

Reviews of doctors report that this medication should be taken only after an individual consultation with a specialist.

Tablets "Tizalud" are taken orally (orally), washed down with plain water, regardless of the meal.

The dosage of this medicine depends on the type and course of the disease. According to the instructions, for neurological pathologies that cause painful (spastic) contraction of muscle tissue, it is recommended to start treatment with daily dose, equal to 6 mg, which is divided into three doses. Depending on the nature of the spasm and pain, the next 3-7 days this amount of the drug can be increased by 2-4 mg.

As medical practice shows, the maximum therapeutic effect is observed when taking a daily dose of 12-24 mg. At the same time, 36 mg is the maximum allowable daily dosage.

To stop painful spasms of skeletal muscles, tablets "Tizalud", reviews of which are ambiguous, are prescribed three times a day for 2-4 mg. In especially severe cases, doctors recommend an additional medication at night in the same amount (that is, 2-4 mg).

The duration of the use of the drug "Tizalud" depends on the dynamics of muscle-tonic and pain manifestations. Usually, sharp pains in muscles require careful treatment for 8-20 days. In chronic pain syndrome, depending on the severity and origin, the patient may need a longer therapy, which is determined on an individual basis (may last for one year).

Side reactions

Unfortunately, taking the medication in question can cause many negative reactions from the central nervous system, digestive tract, cardiovascular and respiratory systems, and others. Among the most frequently manifested side effects are the following:

  • nausea, hepatitis, dizziness, dyspepsia;
  • drowsiness, bradycardia, hallucinations;
  • liver failure, sleep disturbances, dry mouth;
  • insomnia, increased activity of liver transaminases, muscle weakness, lowering blood pressure;
  • increased fatigue, hypercreatininemia.

It should also be noted that the abrupt withdrawal of the drug "Tizalud", especially after its combination with antihypertensive drugs and prolonged treatment or taking large doses, can quite easily lead to the development of tachycardia, increased blood pressure, and in some cases to acute disorder cerebral circulation.

Overdose of tablets "Tizalud"

With a sufficiently gross and regular violation of the dosing regimen, as well as when taking high doses of the drug in question, the patient experiences the following conditions: drowsiness, nausea, turning into vomiting, dizziness, development of hypotension, anxiety, miosis, coma, respiratory failure.

With such symptoms, the patient requires immediate gastric lavage, as well as bowel cleansing with an enema. In addition, the victim is shown taking sorbents, diuresis (forced) and further symptomatic therapy.

Interaction with other medicines

With which medicines Is it forbidden to take the drug "Tizalud"? Concurrent use of this medication with Fluvoxamine, Ciprofloxacin and other potent inhibitors of the CYP1A2 isoenzyme (including Amiodarone, Mexiletine, Propafenone, Cimetidine, Norfloxacin, Enoxacin, Pefloxacin, Ticlopidin ”, “Rofecoxib” and oral contraceptives) is not allowed.

Antihypertensive drugs significantly increase the risk of lowering the patient's blood pressure and the development of bradycardia.

Ethanol and sedatives may enhance the hypnotic effects of tizanidine.

Special Information

When conducting long-term therapy with the drug "Tizalud", doctors need to monitor the condition of the patient's liver at least once a month (preferably during the first four months of treatment).

Due to the risk of a "withdrawal syndrome" when treatment is refused, the dose of tizanidine should be reduced gradually.

It is better to refuse tablets "Tizalud" if professional activity the patient is associated with driving vehicles and carrying out dangerous or precise work.

Cost, analogues

The cost of the drug in question in Russian pharmacies is about 130-175 rubles (for 30 tablets, 2 mg and 4 mg). If required, this medication can be replaced by such means as Tolperil, Lioresal, Mydocalm, Baklosan, Tolperizon and others.

In this article, you can read the instructions for use medicinal product Thezalud. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Tizalud in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Tizalud analogues in the presence of existing structural analogues. Use for the treatment of spasms of the muscles of the spine with osteochondrosis and after a stroke, sclerosis in adults, children, as well as during pregnancy and lactation. The composition of the drug.

Thezalud- a centrally acting muscle relaxant. Reduces the increased tone of skeletal muscles, relieves their spasm; reduces muscle resistance during passive movements, increases the strength of voluntary contractions. The muscle-relaxing effect of tizanidine is probably due to the inhibition of spinal polysynaptic reflexes, which is associated with a decrease in the release of excitatory amino acids from the presynaptic terminals of spinal interneurons, as well as stimulation of alpha2-adrenergic receptors. Tizanidine does not affect the transmission of excitation in neuromuscular synapses.

Compound

Tizanidine hydrochloride + excipients.

Indications

  • spastic condition of skeletal muscles caused by neurological diseases (multiple sclerosis, chronic myelopathy, stroke, degenerative diseases of the spinal cord);
  • Painful skeletal muscle spasm due to damage to the spine (cervical and lumbar syndromes) or arising after surgery (for a herniated disc or hip osteoarthritis).

Release forms

Tablets 2 mg and 4 mg.

Instructions for use and dosing regimen

To stop painful spasm of skeletal muscles, 2-4 mg 3 times a day are used; in severe cases, it is additionally recommended to take 2-4 mg at night.

In spastic conditions of muscles caused by neurological diseases, the initial dose is 6 mg per day in 3 divided doses. The dose is gradually increased by 2-4 mg per day every 3-7 days. The optimal therapeutic effect is usually achieved at a dose of 12-24 mg per day, divided into 3-4 doses. Do not exceed a dose of 36 mg per day.

Side effect

  • drowsiness;
  • insomnia;
  • feeling tired;
  • dizziness;
  • dry mouth;
  • nausea;
  • some decrease in blood pressure;
  • bradycardia;
  • muscle weakness;
  • increased activity of transaminases in serum.

Contraindications

  • hypersensitivity to tizanidine;
  • pregnancy;
  • children under 18 years old.

Use during pregnancy and lactation

Since controlled studies of the use of Tyzalud in pregnant women have not been conducted, it should not be used during pregnancy.

At the time of treatment with tizanidine should be discontinued breast-feeding, because there is no data on its penetration into breast milk.

Use in children

Contraindicated in children and adolescents under the age of 18 years (not enough clinical data to use the drug in this age group of patients).

special instructions

Use with caution in patients with impaired liver and kidney function.

Hypotension may occur during the use of tizanidine, as well as as a result of interaction with inhibitors of the CYP1A2 isoenzyme and / or antihypertensive drugs. A pronounced decrease in blood pressure can lead to loss of consciousness and collapse.

When tizanidine therapy is stopped, in order to reduce the risk of developing a rebound increase in blood pressure and tachycardia, the dose should be slowly reduced until the drug is completely discontinued, especially in patients receiving high doses of Tizalud for a long time.

Influence on the ability to drive vehicles and control mechanisms

At the beginning of treatment, if drowsiness occurs, activities requiring a high concentration of attention, rapid psychomotor reactions should be avoided.

drug interaction

With simultaneous use with antihypertensive agents (including diuretics), severe arterial hypotension and bradycardia may develop.

The simultaneous use of tizanidine with fluvoxamine or ciprofloxacin, which are inhibitors of the CYP1A2 isoenzyme, is contraindicated.

When using tizanidine with fluvoxamine or ciprofloxacin, there is a 33-fold and 10-fold increase in tizanidine AUC, respectively. The result of combined use may be a clinically significant and prolonged decrease in blood pressure, accompanied by drowsiness, dizziness, a decrease in the rate of psychomotor reactions (in some cases, up to collapse and loss of consciousness).

It is not recommended to prescribe Tizalud together with other inhibitors of the CYP1A2 isoenzyme - antiarrhythmic drugs (amiodarone, mexiletine, propafenone), cimetidine, some fluoroquinolones (enoxacin, pefloxacin, norfloxacin), rofecoxib, oral contraceptives, ticlopidine.

With the simultaneous use of ethanol (alcohol), drugs with a sedative effect, the sedative effect is enhanced.

The systemic bioavailability of tizanidine in male smokers (more than 10 cigarettes per day) is reduced by approximately 30%. Long-term tizanidine therapy in male smokers may require higher doses than average therapeutic doses.

Sedatives, hypnotics (benzodiazepines, baclofen) and other drugs such as antihistamines may also increase the sedative effect of tizanidine.

Analogues of the drug Tizalud

Structural analogues for the active substance:

  • Sirdalud;
  • Tizanidine;
  • tizanidine hydrochloride;
  • Tizanil.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Tizalud is a centrally acting muscle relaxant used to treat diseases of the musculoskeletal system.

Pharmacological action of Tizalud

The active substance Tizalud belongs to centrally acting muscle relaxants. The drug is effective in the treatment of acute painful muscle spasms and chronic spasms of cerebral and spinal origin. Taking Tizalud tablets can reduce muscle stiffness during passive movements.

The action of the drug is based on the inhibition of the polysynaptic transmission of excitation in the spinal cord, in which the regulation of skeletal muscle tone occurs.

Tizalud, according to the instructions, can cause a “withdrawal” syndrome, therefore, at the end of treatment, the dose must be reduced gradually.

Release form and composition

The drug Tizalud is produced in the form of tablets containing the active substance (tizanidine) in the amount of 2 mg and 4 mg.

Tizalud's analogues for the active substance are the medicines Sirdalud, Tizanidin-Teva, Tizanil and Sirdalud MR.

If necessary, due to hypersensitivity or contraindications, the doctor may recommend the use of one of the Tizalud analogues with a similar mechanism of action: Baclosan, Tolperison-OBL, Mydocalm, Tolperison and Mydocalm-Richter.

Indications for use Tizalud

The drug Tizalud according to the instructions is prescribed for the treatment of painful muscle spasms:

  • Associated with functional and organic disorders of the spine, including osteochondrosis, cervical and lumbar syndromes, syringomyelia, spondylosis and hemiplegia;
  • Arising after surgical operations, including operations for osteoarthritis of the hip joint or herniated disc;
  • Arising from spasticity of skeletal muscles against the background of various neurological diseases, including multiple sclerosis, chronic myelopathy, degenerative diseases of the spinal cord, residual effects stroke, traumatic brain injury, cerebral palsy.

Contraindications

According to the instructions Tizalud contraindicated to take:

  • Against the background of hypersensitivity to the active (tizanidine) or auxiliary components that make up the tablets;
  • During lactation;
  • Simultaneously with potent inhibitors of the CYP1A2 isoenzyme;
  • Against the background of severe liver failure;
  • During pregnancy;
  • In pediatrics.

With extreme caution, you should take Tizalud tablets:

  • Simultaneously with oral contraceptives;
  • With arterial hypotension;
  • Against the background of hepatic or renal insufficiency;
  • With the syndrome of congenital prolongation of the Q-T interval;
  • Against the background of bradycardia;
  • Elderly people over 65 years old.

Method of application and dosage

To reduce the severity of painful muscle spasm, 1-2 tablets of Tizalud (2 mg) are usually prescribed three times a day. When severe course diseases, you can additionally take a single dosage at night.

In the treatment of spasticity, which is caused by neurological diseases, Tizalud is prescribed at an initial dosage of 2 mg, which is taken 3 times a day. Perhaps a gradual increase (at intervals of 3-7 days) of a single dosage of 2-4 mg. The maximum daily dosage is 36 mg divided into 3-4 times.

When prescribing Tizalud in a daily dosage of more than 12 mg, it is necessary to evaluate liver function at least once a month for four months. If the activity of AST and ALT during this period exceeds upper bound the norm is more than 3 times, the reception of Tizalud is stopped.

Side effects of Tizalud

Medication Tizalud most often causes dizziness, drowsiness, lowering blood pressure, dryness of the oral mucosa, fatigue, bradycardia, hypercreatininemia.

In addition, according to reviews, Tizalud can lead to the development of:

  • Insomnia, hallucinations and sleep disorders (nervous system);
  • Dyspepsia, nausea, hepatitis and liver failure (digestive system);
  • Muscle weakness (musculoskeletal system).

Abrupt cancellation of Tizalud after prolonged therapy, as well as after taking it in high doses or simultaneously with antihypertensive drugs, can cause tachycardia, increased blood pressure, and in some cases, acute cerebrovascular accident.

Also, Tizalud, according to reviews, when taken in high doses, can lead to an overdose, manifested in the form of nausea, respiratory failure, vomiting, a pronounced decrease in blood pressure, dizziness, drowsiness, miosis, anxiety, coma. For treatment, in addition to gastric lavage, multiple doses are indicated. activated carbon. Also in this case, forced diuresis is performed.

drug interaction

According to the instructions, Tizalud is not recommended to be taken simultaneously with antihypertensive drugs due to the risk of a pronounced decrease in blood pressure and the development of bradycardia. It is also considered undesirable to use the drug together with other alpha2-agonists.

Sedative drugs and ethanol can increase side effects associated with depression of the central nervous system.

Simultaneous use with oral contraceptive medicines may lead to a decrease in the effectiveness of Tizalud.

Storage conditions

Tizalud is one of the centrally acting muscle relaxants dispensed from pharmacies as prescribed by a doctor. The shelf life of the tablets is 24 months, subject to the manufacturer's recommended storage conditions.