Modern drugs for the treatment of syphilis. Treatment methods for syphilis, drugs Bismuth preparations are used to treat syphilis

Syphilis is a dangerous and widespread disease throughout the world, requiring immediate medical attention immediately upon detection. Over the past few centuries, various drugs have been used to treat syphilis. Some of them were more effective, others were less. Nevertheless, due to the fact that the causative agent of the disease - pale treponema - did not mutate during this period, it was possible to try different remedies for syphilis and develop general schemes for the main and reserve therapy. To date drug treatment syphilis is the main and only confirmed method of therapy. Preparations for syphilis can be prescribed not only to patients, but also to people who are in close contact with them, for example, their children or cohabitants.

Preparations and means for the treatment of syphilis

Medicines for syphilis

Patients should be aware that this disease is very serious and, without proper regular therapy, can lead to the death of the patient. You should not self-medicate by taking syphilis medications that are not prescribed by a doctor, increasing or decreasing the dosage on your own. This is due to the fact that the disease often manifests itself as a multitude of concomitant HIV diseases, negatively affects the mucous membranes, skin, and, with a long course, the work of many organs. In addition, many possible forms of development can be resistant to one or another anti-syphilis drug. So, for example, in the fight against neurosyphilis, it is necessary to use those agents that easily penetrate into the cerebrospinal fluid. Otherwise, therapy will be ineffective.

Treatment of syphilis with pills

Treatment of syphilis with tablets, as a separate form of therapy, is justified on initial stages diseases and only if the patient does not have other HIV infection. Also, preference for drugs against treponema in tablet form is given if, as a result of long-term therapy, there have been changes in the structure of the muscles that prevent the normal absorption of drugs administered with injections. Many modern drugs, produced in the form of tablets, are successfully fighting such a difficult form of the disease as neurosyphilis. As already mentioned, this form of release of medications avoids destructive changes in the gluteal muscles and excessive traumatism of blood vessels, however, the gastrointestinal tract is substituted for the main blow of side effects. At the first manifestations of peptic ulcer, inflammation of the kidneys or liver, most of these drugs have to be abandoned.

In addition to the main therapeutic effect, tablets in the treatment of treponema are used as an auxiliary therapeutic agent, immunostimulating or anti-allergic. In the latter case, they are prescribed before the first injection of a drug not previously taken, half an hour before the injection.

Injections for syphilis

Injections for syphilis are given either intravenously or in the upper quadrant of the buttocks. In most cases, the second option is much more preferable, since they do not have such a negative effect on blood vessels as in the first case. However, in particularly severe cases, it is intravenous injections that are prescribed. Intramuscular injections are always made in the buttock, each time choosing a new place for the next piercing. The correct calculation of the thickness of subcutaneous fat is very important for systematic treatment, since drugs are absorbed from the subcutaneous tissue much more slowly, and repeated injections in the same place will cause pain in the patient, severe muscle swelling and excessive growth of connective tissue, followed by scarring. Therefore, in medical institutions, the first injection is made closer to the line of the spine, each time moving away from it, alternating either the right or the left buttocks for the next punctures.

Recently, more and more often you can find ads for the treatment of syphilis with one injection, but as practice shows, this is just another way to lure money from patients, and even if the symptoms of the disease temporarily disappear, not 1 or even 4 injections can cure a person! But they will be able to translate the disease into a latent form, thereby aggravating the situation.

Treatment of syphilis with mercury was one of the earliest means of combating this disease, which began to be used as early as the 16th century. And although Hg in many cases helped fight the disease, unnecessarily large dosages of drugs containing mercury, tablets based on it, injections into the vein and inhalation of vapors often led to side effects that turned out to be much more difficult to cope with than the disease itself. Therefore, during the treatment with this remedy, it was very high rate patient mortality.

Despite this, many doctors continued to poison their patients with incorrectly calculated doses or suggested that they constantly carry special bags with evaporating mercury. And only in 1865, Russian scientists Konoplev and Sokolov proposed the use of sublimate injections, which make it possible to more accurately calculate the dosage of the drug administered to the patient.

Today, traditional medicine prescribes medical treatment of syphilis with mercury in some cases. Also continue to use this remedy and representatives of homeopathy. With regard to traditional medicine, it is justified to administer small doses of Hg to newborns and young children, if they have lesions of the skin or mucous membranes. Usually, substances are administered in the form of a mixture or powder, so the doctor, suspecting pale treponema, may prescribe them secretly, waiting for the results of the examination.

Sometimes mercury ointments are used to rub into the skin, but only in cases of unsuccessful conventional treatment or poor absorption of the gluteal muscles.

Another remedy used today in the treatment of patients is mercury injections, the indications for which are the same as for conventional antibiotic injections. At the same time, the course of treatment is longer, and side effects- more.

Treatment of syphilis with antibiotics

In modern medicine, it is the use of antibiotics for the treatment of syphilis that is the most justified solution, since these drugs, in most cases, show a quick result in the fight against treponema pallidum with minimal side effects. Antibiotics for syphilis can be prescribed both in the form of tablets and in the form of injections, depending on the stage of development of the disease, the presence of chronic diseases, allergic reactions, and much more.

On the this moment The most common antibiotics are penicillins. They are assigned first. In case of contraindications to them, they begin to use other means: macrolides, cephalosporins, tetracyclines.

Penicillin

Treatment of syphilis with penicillin was first used in the 40s of the last century. Due to the fact that the virus has not mutated during this time, it remains the No. 1 drug in therapy. this disease. Penicillin for syphilis shows an effectiveness that is not available to many other broad-spectrum antibiotics, but it often causes an allergic reaction. Therefore, as soon as the diagnosis is confirmed, an allergy test is taken from the patient, and when negative result proceed to drug therapy. Penicillin, after its administration, begins to act quickly in the body, which is its undoubted advantage, but the speed of its removal from the body forces doctors to prescribe injections at intervals of 3-4 hours, which makes outpatient treatment with this drug impossible and requires the patient to be hospitalized.

In the case of a positive allergy test, the doctor decides for himself which drugs to treat syphilis in this particular case.

Bicillin

Bitsillin for syphilis is prescribed either as the main drug or as a medication to complete the successful treatment of the disease. There are 4 types of drugs with a common name - bicillin. They differ from each other in the concentration and composition of the main active substances, which affects not only its antibiotic properties, but also the different frequency of injections during therapy. So, Bicillin 3 is usually administered twice a day, while the drug with number 1 is administered once a day. For outpatient treatment or to help other antibiotics against pathogens, bicillin 5 is often prescribed, which is excreted from the body in 4-5 days, which allows 1-2 injections per week, while the same penicillin requires 3-4 injections in a day.

With pronounced allergic reactions to penicillin drugs or bicillin, it is prohibited to prescribe this drug.

Ceftriaxone

Ceftriaxone for syphilis is prescribed in case of allergy to penicillin preparations. It has unique properties and effectively fights against most pathogens, including Treponema pallidum. The drug has a slightly less pronounced effect compared to penicillin, but its half-life is about 8 hours, which allows you to prescribe injections once a day without requiring hospitalization of patients. Ongoing studies have shown its effectiveness as a medical reserve for primary and secondary forms of syphilis, however, little experience with its use and the lack of data on harm to pregnant women does not allow recommending the drug to pregnant women and children.

Doxycycline

Doxycycline is another antibiotic that has been widely used since the 1990s. On average, taking doxycycline twice a day, the treatment of syphilis lasts 10-30 days, which is only slightly longer than with benzylpenicillin drugs. The release form of this medication- ampoules. On the day, the patient is prescribed 2 injections of 1 g, trying to distribute them over time at equal intervals. Doxycilin has a slight photosensitizing side effect on the skin, so in the summer during the treatment period, patients are advised to stay in the sun as little as possible. Also, the drug negatively affects bone growth, which should be considered when prescribing it to children.

Sometimes doxycycline is used at the stage of preparing patients in subsequent penicillin therapy, especially in cardiovascular syphilis.

When choosing doxycycline, the doctor must take into account that this drug should not be prescribed to pregnant women.

Sumamed

With syphilis, sumamed is used as an analog drug. This agent is usually referred to as bacteriostatics, which does not prevent it from showing an association constant with ribosomes 8 times higher than that of other drugs of the azalide series. This makes it possible to achieve effective suppression of protein synthesis on early stages development of the disease, and does not allow the disease to develop. If the patient has a non-early form of the disease, sumamed can be prescribed as an additional non-specific medication to speed up the cure for neurosyphilis, a congenital form of syphilis, a recurrent or latent type of disease, and also in the presence of other pathologies.

A positive property of the drug is its ability to accumulate in tissues to a concentration exceeding its content in the blood by 50 times, while sumamed will be excreted from the body for at least seven days. The disadvantage of this medication is impermeability to the cerebrospinal fluid and a negative effect on the liver and kidneys.

Azithromycin

With syphilis, azithromycin began to be prescribed relatively recently. Since this drug is new, we immediately conducted experiments on its safety and a comparative test for effectiveness. Tests were carried out in the USA for seven years. According to the test results, a similar efficacy of drugs was established and almost complete absence side effects. But the weak side effects were observed quite often and accounted for about 60% of all cases of treatment with azithromycin, however, serious dysfunctions of the body were manifested to a much lesser extent than in the control group taking penicillin.

Despite the encouraging result of the experiment, the effect of the drug on the body of pregnant women has not been studied. In addition, if the patient has several concomitant HIV diseases, azithromycin may be almost completely useless.

Tetracycline

Treatment of syphilis with tetracycline is prescribed mainly in the initial stages of primary and secondary disease, if the patient needs to switch from injections to tablets. It is necessary to take tetracycline four times a day, at regular intervals for 15-40 days, depending on the form of the disease.

When prescribing this drug, it is necessary to warn the patient about the undesirability of drinking milk during the period of therapy, as well as substances that reduce the acidity of the stomach. If therapy takes place in the summer, then they warn of the need to hide from the sun's rays.

children preschool age and pregnant women are not prescribed tetracycline.

Erythromycin

Erythromycin is almost never used in syphilis if it is possible to use a much more effective benzylpenicillin, however, as a reserve drug, it has proven itself well. Erythromycin is classified as a macrolide.

Erythromycin is often prescribed to young children, as it is currently considered the safest anti-syphilis drug. With neurosyphilis, this remedy is useless, since it does not penetrate into the cerebrospinal fluid.

The harmlessness of erythromycin negatively affected its aggressiveness to the causative agent of the disease, so this remedy is often combined with various kinds of bismuth drugs or a longer course of therapy is prescribed.

Amoxicillin

Amoxicillin for syphilis is used as a semi-synthetic analogue of penicillin. The advantage of this tool is a wide range of its action. Acid resistance, which made it possible to produce it in tablets for oral administration and the speed of action after taking medications, allows you to reach the maximum concentration in the blood in 2 hours. Good absorption of amoxicillin allows you not to tie the hours of admission to food. The main thing is to adhere to equal intervals between the use of the drug.

It is not advisable to use this remedy instead of penicillin in the absence of allergic reactions, since it is significantly inferior in effectiveness to benzylpenicillin. Also, do not combine amoxicillin with antibacterial agents, as they will suppress each other.

Ampicillin

In syphilis, ampicillin is used as a semi-synthetic analogue of penicillin. In its structure, the drug is extremely similar to penicillin, both in terms of its effect on gram-negative and gram-positive microorganisms. Therefore, it is often prescribed as a broad-spectrum drug when the disease is already clearly established, but there is no specific data on its etiology.

The similarity with penicillin allows you to use not only the dignity of the drug, but also its disadvantages. For example, if the disease is caused by microorganisms that destroy penicillin, then ampicillin will also be destroyed.

Good results can be achieved by combining ampicillin treatment with B and C vitamins.

Alternative treatment of syphilis

Treatment folk remedies syphilis as a separate method of therapy, without resorting to doctors, is not able to cure the patient, but only starts the disease, which can cause death.

But the use of various herbs as additional method exposure will not only accelerate the recovery of the patient, but also reduce, and in some cases help to avoid the negative consequences of taking antibiotics that adversely affect the human body.

But before you start taking certain herbal infusions, you should consult with your doctor to find out what consequences they will have on the drugs you take, and whether they will harm the body more than help.

Treatment of syphilis with homeopathy

The treatment of syphilis with homeopathy began to be used in the 18th century. The principle of this unconventional effect on the body is an attempt to arouse the patient's immune response by giving him drugs that can also cause symptoms of pale treponema in a healthy person. Usually, preparations with diluted mercury and iodine are used for this, but in small proportions, which they drink weekly, alternating with each other.

From the point of view of theory, this is interesting, but after breeding active substance in the proportion of 1/100, it is not possible to talk about benefit or harm, since such small numbers are within the limits of mathematical errors.

Whatever medication you start the fight against syphilis, the main condition for successful treatment remains - the systematic intake of prescribed medicinal products at the dosage prescribed by the doctor.

Venereal diseases are a heavy burden for a person and a retribution for sensual pleasures. Without them, with what relief the owners of a hot temperament would sigh! However, many are not stopped by the danger of infection through sexual intercourse. Promiscuous sex life and unprotected sex are the cause of a wide variety of diseases of a viral and bacterial nature. One of them, known for a long time and deadly. Fortunately, modern medicine It has various drugs against syphilis. The success of its application directly depends on the timeliness of treatment.

The causative agent of the "Gallic" disease, as it was called in the 16th century in Europe, is pale treponema, a special type of spirochete. This bacterium penetrates the human blood and causes changes in the mucous membranes and skin, as well as in the nervous system. If the patient is not treated, there will come fatal outcome. Successful treatment and prevention of syphilis became possible in the 20th century, when antibiotics were discovered. These substances are introduced into the human body, and selectively affect the causative agent of syphilis, destroying it. There are several types of antibiotic drugs prescribed for syphilis.

Antibiotics of the penicillin series

Penicillin is an antimicrobial drug discovered in the 1920s. Most effective remedy against syphilis. Despite the long-term practice of penicillin therapy, pale treponema has not developed any protective mechanisms and is completely destroyed by the antibiotic. In addition to pure penicillin, its derivatives are used, which have patented pharmacological names:

• Benzathinepenicillin G;

• Retarpen;

• Bicillin.

The first two drugs are foreign-made, French and Austrian, respectively. They cost a lot, and finding them is more difficult than the third. Bicillin is produced in Russia and is relatively cheap.

Penicillin antibiotics are injected into the body. Penicillin tablets are slowly absorbed and their antimicrobial effects are severely limited by the patient's liver. Injections are made intramuscularly, less often in the lymphatic channel or intravenously.

Cephalosporins

These antibiotics are often considered as an alternative to the well-known penicillin. The fact is that a fairly large percentage of patients have an allergy or complete intolerance to penicillin preparations. Then the drugs of the cephalosporin group come to the rescue. They rarely cause allergies, but their action is often blocked by the body, so they need to be used in combination with activator drugs.

The most famous pharmaceutical drug for syphilis is Ceftriaxone. For intramuscular injections, it is dissolved in lidocaine, for intravenous infusions - in solutions of NaCl, dextrose or levulose. Ceftriaxone affects not only the causative agent of syphilis itself, but also skin formations, for example,.

Reserve row antibiotics

It often happens when a patient has a combined intolerance to penicillin and cephalosporin. Pregnant women also fall into the risk category, for whom the treatment of syphilis is especially important. It should be immediately pointed out that they do not completely destroy pale treponema, but simply stabilize the clinical picture: they slow down the growth and reproduction of bacteria. Therefore, their use is forced, since allergic reactions can cause anaphylactic shock. Among the most commonly used reserve drugs are:

1. Tetracycline. Bacteriostatic antibiotic. Included in the list of essential medicines Russian Federation. It inhibits treponema, which masks the symptoms of syphilis, but does not kill it. The use of tetracycline is accompanied by periodic testing. Price: from 28 to 59 rubles.
2. Erythromycin(price: from 22 to 138 rubles) and sumamed(price: from 215 to 958 rubles). Macrolide antibiotics have a stabilizing effect on patients with syphilis.
3. Doxycycline. This drug also belongs to tetracyclines. When it is used in the colonies of the pathogen, protein synthesis is inhibited. As a result, spirochetes lose their ability to progress the disease. Price: from 20 to 32 rubles.

Unlike penicillin-based drugs, reserve antibiotics are allowed to be given in tablets. The mechanism of absorption and crossing the blood-brain barrier is somewhat different, so tablets have almost the same effect as injections. It is worth remembering that the effectiveness of many of these drugs is insufficient for a complete cure. They are successfully used only at the first stage of the development of syphilis or to slow down the rate of development at the third stage, before the main course of treatment.

Treatment regimens

The doctor observing the patient always prescribes a course of treatment individually, based on the characteristics of the patient's body and clinical picture what is happening. Groups of the most commonly used methods are combined into typical treatment regimens. However, the above schemes cannot be a guide to action in self-treatment and are provided for informational purposes only.

Treatment of primary syphilis

Primary syphilis is the initial stage of the disease. For its treatment during this period, the following schemes can be used:

1. Ultra short scheme. In the first days after infection, an attempt is made to completely eliminate the pathogen. Usually, imported drugs with a strong effect are used for this.
2. preventive treatment. This type of treatment differs in that it begins regardless of the test results. The basis is the complaint of the patient, his suspicion of unprotected intercourse with an unsafe partner. Considering that the best result is achieved within 2 days from the moment of penetration into the body, the right dose of penicillin can solve the problem even before the onset of symptoms.

The best results among medicines for the treatment of primary syphilis show drugs penicillin group.

What do you think is the best treatment regimen for syphilis?

Ultra short circuitPreventive treatment

Benzylpenicillin with novocaine salt base. The application instruction is simple. Dosage - 600 thousand units 2 times a day. The course of treatment is 20 days.

The active substance is also benzylpenicillin, but this time based on the sodium salt in crystalline form. Dosage - 1 million units 6 times a day with a four-hour interval. The duration of the course is also 20 days.

Treatment of tertiary syphilis

Tertiary syphilis is an advanced form of the disease. If the sick person is not treated in a timely manner or treated incorrectly, but in addition to damage to the external integument, the stage of fundamental changes in the body begins. Chronic syphilis is especially dangerous for the nervous system and eyes. Pale treponema begins to damage the nerve channels, as a result, even before death, a person can become blind.

You can also look at the photo for one of the symptoms of tertiary syphilis.

For the treatment of the tertiary stage of development of syphilis, a complex scheme is used:

• Its difference is that in addition to measures to neutralize the virus, it is also necessary to take drugs that strengthen the immune system, as well as eliminate the bodily consequences of syphilis in the form of chancres, visicles, rashes, ulcers of varying severity. Most of these manifestations can only be eliminated surgically.
• To get rid of the bacteria of the pathogen, the same benzylpenicillin is used. Its dose remains the same - 1 million units per day, however, the course of treatment after 28 days is repeated up to a complete negative reaction to pale trepanema in the analysis. This medicine is unanimously recognized as the most effective.

However, along with antibiotics, other modern drugs from syphilis to alleviate the suffering of the patient and increase the chances of recovery.

For example, with dangerous neurosyphilis, with a danger of damage to the optic nerves, the following medications are also prescribed:

1. retinol for better blood supply to the retina;
2. nicotinic and ascorbic acids, which have an anti-inflammatory effect;
3. vitamins B6 and B12, which contribute to the saturation of blood and nerve tissues with oxygen.

These measures are designed to ensure the death of the pathogen in the nerve fibers and their subsequent recovery.

Expert opinion

Artem Sergeevich Rakov, venereologist, more than 10 years of experience

Antibiotics Ceftriaxone, tetracycline and other macrolides are introduced into the course of treatment of a patient with the third stage of syphilis in that case. When individual intolerance to penicillin can hurt more than help. The development of the disease is urgently suspended by any means in order to prepare the body for taking penicillin-containing drugs without consequences.

Syphilis is a long-standing and unpleasant disease. However, unlike many sexually transmitted infections, especially viral ones, it is treated modern means without too much trouble. Therefore, we can recommend to those who have an active libido that caution and attention to the state of your body is the best prevention of sexually transmitted diseases. In the early stages, it is much easier to cure them than years later, when irreversible changes can occur in the body.

You can also watch the video in this article, where the doctor will tell you what drugs treat syphilis.

The difficulty of getting rid of syphilis comes from the difficulty of diagnosing it, in the early stages. The treatment regimen is selected based on the type of disease, as well as the stage of development. And a separate medicine for syphilis is selected taking into account the characteristics of each case individually.

Basic principles of drug therapy

Syphilis is usually divided into sexual and domestic. The principles of their treatment are largely similar. In the bulk of cases, therapeutic regimens are based on the use of drugs from the category of strong antibiotics, as a rule, in injections. About which injections from syphilis are most effective, we will consider below.

Groups of drugs against this disease are represented by the following types of medicines:

• penicillin;
• macrolide antibiotics;
• tetracyclines;
• Ceftriaxone.

The above drugs against syphilis are most often used in therapeutic methods.

At the same time, questions are asked about pills. So, the treatment of syphilis with pills is present in medical practice, but it also has a number of nuances in the selection of drugs.

The most commonly used Rovamycin, Sumamed, Cefotaxime and Amoxicillin. You have to take pills for a long time, but their effect can be quite weak, which will only lead to the elimination of primary symptoms.

Penicillin series

Among the most common schemes of therapeutic methods can be called "penicillin series or blockade", which is based on water-soluble penicillin.

This method is indicated for use in cases where it is necessary to introduce a higher concentration of the substance into the area of ​​the affected tissues, as well as in cases of diagnosing neurosyphilis. As for the moment, how much such treatment costs, it costs no more.

Intolerance to antibacterial drugs in a patient

Often, the patient and the attending physician are faced with the question of what methods and medications to use during therapy if the patient has intolerance to antibacterial medicines. In the bulk of cases in such situations, they are treated with tetracycline drugs, in particular, tetracycline is prescribed.

As well as complex therapy with the following drugs:

• Erythromycin;
• Doxycilin;
• Sumamed.

The choice of drugs largely depends on the stage of development of the disease. So, in the early stages of the disease, Azithromycin, aka Sumamed, can be prescribed. It is recommended to fight advanced forms or latent syphilis with the complex prescription of antibiotics and bismuth preparations. In case of intolerance to the above medicines, they can be completely replaced with cefazolin injections.

The scheme of application of drugs is as follows:

• Tetracycline - 2 times a day, contraindicated in case of hearing loss and kidney disease, children under 8 years old;
• Doxcilin - 2 times a day, it is forbidden to stay in direct sunlight during treatment, it negatively affects bone tissue.

Features of treatment with ceftriaxone

Continuing the consideration of the question of how to stop syphilis, what injections, whether the disease is treated, it is necessary to reveal the features of the use of ceftriaxone.

So, when prescribing this antibiotic to patients, a positive trend is observed already in the first week of drug administration.

At the same time, ceftriaxone has several advantages over other medicines:

• It quickly penetrates the body, is effective even at advanced stages of the disease, and also if the virus has entered the brain;
• Appointment to pregnant women is allowed;
• The drug is special in that it prevents further synthesis of the pathogen.

Course treatment with ceftriaxone depends on the stage and form of the sexually transmitted disease.

So, the drug is indicated for use in:

• Neurosyphilis;
• Latent forms of the disease;
• secondary form.

Terms of treatment:

• Preventive and prophylactic treatment - 7 days;
• Initial stage - 10 days;
• Secondary form and latent syphilis - 15-18 days;
• Neurosyphilis in the initial stage - 20 days;
• The last stage of the disease is 18 days and after 2 weeks the course is repeated;
• Meningitis against the background of venereal diseases - 20 days.

Conclusion

Numerous reviews of doctors and patients once again confirm the effectiveness of ceftriaxone. Patients wonder if the disease can be cured with a single injection.

According to doctors, such a technique has not been developed today, since the antibiotic acts as it accumulates in the body, in addition, such drugs are quickly excreted from the body, which in 70% of cases leads to relapse and the development of the disease at an accelerated pace.

This is a disease that occurs due to exposure to the bacterium "treponema pallidum". It strikes internal organs, mucous membranes, musculoskeletal and nervous system. Way of infection - microcracks, injured skin covering and the birth process.

Can pills cure syphilis? Syphilis pills are effective pharmaceutical agent aimed at fighting the disease. The treatment of this disease has a long duration, so only a venereologist can cope with such a task. The choice of drugs and treatment regimen depends on many factors.

In the treatment of syphilis, antibiotics (substances that inhibit the growth of bacteria) are actively used, which act on its causative agent - pale treponema. The main drugs to combat the disease are penicillin and drugs of its series. Tablets and ampoules of penicillin pharmacological action are the same. The only difference is that they have different exposure time and direction. So, let's look at pills against syphilis.

Tetracycline

This antibacterial agent has a bacteriostatic effect. The drug is prescribed for many diseases, including sexually transmitted diseases. The composition of one tablet includes 100 mg of tetracycline hydrochloride.

Dosage: adults - 250 mg every 6 hours, the maximum dose is 2000 mg per day; children from seven years old - 25 mg per kg / m of body every 6 hours.

Tetracycline has a number of contraindications: fungal infections, renal and hepatic failure, age up to seven years, leukopenia, pregnancy, breastfeeding.

Side effects: abdominal pain, glossitis, nausea, vomiting, constipation, diarrhea, allergic reactions, rarely - Quincke's edema.

The price for 100 mg (20 pcs.) - from 47 rubles.

Ceftriaxone

Ceftriaxone is a new generation antimicrobial drug that is effective against microorganisms that develop in oxygen and in an oxygen-free environment. The action of this drug is due to the suppression of cell membranes of pathogenic bacteria.

The dosage of Ceftriaxone is calculated individually and depends on the clinical condition of the patient. In the treatment of syphilis, the duration of therapy depends on the stage of the disease and ranges from 14 to 45 days.

The medicine has contraindications: increased sensitivity to the active ingredient. The antibiotic should be taken with caution in patients with ulcerative colitis, enteritis, with chronic kidney and liver diseases, during pregnancy and lactation.

Price per bottle (1 g) - from 44 rubles.

Antibiotics of the penicillin series

You can familiarize yourself with the following preparations.

Retarpen

A drug with an active β-lactam antibiotic of prolonged action. Effective against streptococci, treponema, staphylococci and other microorganisms.

It is used to treat syphilis and other long-term diseases:

• inflammatory;

• infected wounds;

• erysipelas, tonsillitis.

It is prescribed as a prophylactic in the post-contact period after communication with patients with syphilis and scarlet fever.

Dosage: treatment of primary syphilis - 2 injections (5 ml) with a weekly break; latent early or secondary syphilis - 3 injections with a weekly break.

The drug has contraindications: ulcerative colitis, pregnancy and lactation, hypersensitivity to the components of the drug.

Price per package (2400 million IU) - from 2400 rubles.

Extencillin

Extencillin is a macrolide antibiotic that has a bacteriostatic effect. Effective against chlamydia, streptococci, meningococci, leptospira.

The drug is indicated in the treatment of STIs (sexually transmitted infections), diseases of the genitourinary system, bronchopulmonary and skin pathologies.

The dosage is selected individually and depends on the form of the disease. In the treatment of syphilis, 1 intramuscular injection (2.4 million) is usually prescribed with an interval of 8 days.

Side effects: nausea and vomiting, development of pseudomembranous phlebitis, colitis, discomfort in the epigastric region, skin allergic reactions.

Price per bottle (2.4 million IU) - from 96 rubles.

Bicillin

A natural antibacterial preparation of the penicillin group with an active active ingredient - benzathine benzylpenicillin. Suppresses the synthesis of cell walls and membranes, stopping their reproduction and growth. There are three types of bicillin, each of which has a different composition and concentration of active ingredients.

It is used to treat various sexually transmitted diseases, including syphilis. When treating with bicillin, ascorbic acid and B vitamins are additionally prescribed (for the prevention of fungal infections).

What drug do you think is more effective against syphilis?

BicillinExtencillin

Side effects: nausea and diarrhea, dizziness, headaches, bronchospasm, unstable arterial pressure, allergic skin reactions, rarely - leukopenia, anaphylactic shock.

Bicillin is contraindicated in case of hypersensitivity to novocaine and the active substance, with bronchial asthma, urticaria, ulcerative colitis, hay fever. Possible therapy during pregnancy and lactation (under the supervision of a specialist).

Price per bottle (1.5 million IU) - from 47 rubles.

Doxilan

Bacteriostatic antimicrobial agent with the active ingredient - doxycycline. The drug is similar in pharmacological properties to tetracycline.

Used to treat a number of infectious diseases, diseases caused by pathogenic microorganisms, soft tissue lesions, inflammation of the pelvic organs, pathologies of ENT organs.

Dosage: for primary and secondary syphilis - no more than 300 mg of the drug per day for 2 weeks.

Side effects of taking the drug: headaches, dizziness, fungal infections, vascular collapse, constipation, diarrhea, glossitis, allergic reactions, angioedema, changes in tooth enamel.

Doxilan is contraindicated in liver failure, under the age of 9 years, during pregnancy and lactation.

The price for a package of 100 mg (20 pcs.) - from 29 rubles.

Pills for syphilis during pregnancy

During pregnancy, syphilis is a fairly serious problem, which, according to statistics, is faced by 10% of women. It is dangerous because without the help of a specialist, pathology can cause severe consequences.

A study for syphilis is carried out when a woman is registered in a consultation. If after screening (testing) the diagnosis is confirmed, then two courses of therapy using tablets will be prescribed:

• The first course of treatment is carried out in a hospital, the second prophylactic can be carried out in a home outpatient clinic.
• Treatment during pregnancy greatly reduces the chance of a baby developing syphilis. In the course of therapy, as a rule, prescribe antibacterial agents(penicillin). This is one of the few drugs that do not affect the development of the fetus.
• In addition to penicillin, antibiotics of the penicillin group can be prescribed. The treatment regimen and the dose of the drug are determined only by the doctor and depend on the chosen remedy.

Often, the use of such therapy causes side symptoms: fever, dizziness, nausea. These reactions do not pose a threat to the life of the fetus and most often go away on their own. However, if the pills have caused contractions or pain in the abdomen, you should immediately consult a doctor.

It is forbidden to prescribe medications on your own, even with the observance of the treatment regimen. Uncontrolled use of antibiotics can cause many diseases.

Can pills cure syphilis?

In sexually transmitted diseases, as a rule, various forms of drugs are used. Tablets are used as anti-allergic, immunostimulating and auxiliary agents. Such treatment is most often prescribed in the initial stages, at a later date it is indicated combination therapy using tablets and injections.

Oral therapy is also possible when destructive changes in the gluteal muscle occur due to a long course of injections. In this case, the entire impact falls on gastrointestinal tract. In addition, prolonged use of antibiotics in tablet form can provoke peptic ulcer disease, cause inflammation of the liver.

Each patient is assigned an individual treatment regimen, it directly depends on the following conditions:

• drug tolerance;
• form and stage of the disease;

• the presence of other diseases at the time of screening;
• patient's age;

• the physical condition of the patient;
• the patient's living conditions.

The early stages of syphilis are much easier to treat, in which case it is considered optimal antibiotic therapy. Such treatment takes no more than three months and most often leads to a complete recovery. When the disease is in an advanced form, therapeutic measures can last more than two years. In this case, special therapy (toxic) is carried out with bismuth derivatives (Biyoquinol) or arsenic (Novarsenol, Miarsenol).

The patient is considered healthy if there are no relapses within 5 years after therapy. Today, syphilis is effectively treated at all stages, but for a positive stable result, the help of a venereologist is necessary, as well as strict adherence to all prescriptions.

Expert opinion

Artem Sergeevich Rakov, venereologist, more than 10 years of experience

Syphilis is a dangerous disease. Attempts to be treated independently will not destroy it, but will only aggravate the situation. At the same time, a complete rejection of therapy will inevitably lead to a deterioration in the state of health, a gradual shutdown of organs and, as a result, to the slow death of the infected.

With the right choice of medicine and strict adherence to the instructions of the doctors, the patient has a chance to cope with the disease forever. The main factors for the successful treatment of syphilis are a timely diagnosis, long-term complex therapy and strict adherence to the recommendations of a specialist.

You can also watch the video in this article, where the doctor will tell you about the possibility of treating syphilis.

Poor awareness of a patient with syphilis about his disease and self-treatment lead to a worsening of the epidemic situation. Decisive in the fight against the spread of infection is the high quality of syphilis treatment, which is strictly regulated in the Russian Federation. The tactics of treatment is determined by a dermatovenereologist.

The treatment regimen depends on the form of the disease and the socio-psychological status of the patient and includes specific (antibiotic therapy), non-specific and local treatment.

The most effective is the treatment of syphilis in a hospital under the supervision of medical personnel. Inpatient and outpatient treatment of syphilis on an outpatient basis is indicated for socially adapted persons who wish to be treated and comply with all medical recommendations.

Rice. 1. The photo shows a hard chancre with syphilis in a woman and a man.

Antibiotics for syphilis

The basis of the specific treatment of syphilis is penicillin preparations.

• In hospital treatment, water-soluble penicillin is used. The drug provides a high concentration of the active substance in the patient's body, penetrates the blood-brain barrier. Due to the rapid excretion from the body, repeated administration during the day is required.
• In outpatient treatment, long-acting penicillin preparations (durant preparations) are used: foreign preparations Retarpen and Extencillin and Bicillin-1 - their domestic counterpart.
• Combined antibacterial drugs: Billillin-3 and 5 .
• Antibacterial drugs recommended for use in case of intolerance to penicillin drugs.

Rice. 2. Penicillin mold is the main enemy of pale treponema.

Treatment of syphilis with penicillin

Preparations of the penicillin group are used in the treatment of syphilis in a hospital setting. Water-soluble penicillin is injected intramuscularly every 3 hours, novocaine salt of benzylpenicillin is injected 2 times a day.

Treatment of syphilis with durant drugs

Durant drugs are prescribed for the treatment of syphilis on an outpatient basis. Retarpen, Exentillin and Bicillin-1 administered in a single dose of 2.4 million units. This dose ensures the presence of the drug in the blood serum for a long time - up to 2 - 3 weeks. Exencecillin and Retarpen are administered 1 time per week, 1 time in five days is administered Bicillin-1.

Treatment of syphilis with combined drugs

Combined drugs include penicillin preparations, which consist of 2 - 3 salts - Bicillin-3 and Bicillin-5. The frequency of administration is 2 times a week.

In some patients, a few hours after the start of treatment with antibacterial drugs (usually penicillin), the Herxheimer-Jarish reaction develops, which is characterized by a sudden increase in body temperature, headache and muscle pain, vomiting, tachycardia. This phenomenon is due to the mass death of pathogens. Symptoms are quickly relieved by aspirin.

Endolymphatic penicillin therapy

Professor E. A. Batkaev (Department of Dermatovenereology, RMAPO) developed a method for administering penicillin directly into the lymphatic vessels - endolymphatic penicillin therapy. The method is recommended to be used when it is required to create a higher concentration of the antibiotic in the affected tissue, as well as in the treatment of neurosyphilis.

Rice. 3. Retarpen and Exencecillin are drugs for the treatment of syphilis of prolonged action.

Penicillin preparations are the main ones in the treatment of syphilis.

Treatment of syphilis with intolerance to the main antibacterial drugs

In some patients, there is an increased sensitivity to penicillin preparations, in some patients the drugs in the doses used do not penetrate the blood-brain barrier, in others there is no negative control serological reactions after treatment with long-acting penicillin preparations. In such cases, it is recommended to use Tetracycline, Erythromycin, Doxycycline or Sumamed, Ceftriaxone other. It is desirable to prescribe these drugs for 14-30 days in increased daily doses.

In case of intolerance to benzylpenicillin preparations, it is recommended to treat syphilis with semi-synthetic penicillins. Ampicillin or Oxacillin.

With combined intolerance to penicillin, tetracycline and erythromycin, it is recommended to prescribe Cefazolin. Fresh forms of syphilis can be treated Sumamed (Azithromycin). In the treatment of late latent syphilis, antibiotics are prescribed together with bismuth preparations.

The tactics and treatment regimen for syphilis is determined by a dermatovenereologist and depends on the form of the disease and the socio-psychological status of the patient.

Rice. 4. Hard chancre on tongue and lip.

Pathogenetic treatment

Comprehensive treatment with the inclusion of immuno- and enzyme therapy, adequate local therapy and treatment of concomitant chronic diseases genital organs is a significant reserve for improving the quality of antisyphilitic therapy, contributes to the negativity of serological reactions after the end of specific therapy.

In addition to antibiotics, immunotherapy is used in the treatment of syphilis. The immune system suppresses the development of new foci, removes toxins and destroyed bacteria from the body, and protects the body from re-infection. Immunotherapy increases the effectiveness of syphilis treatment, improves the prognosis of the disease and the patient's quality of life.

1. Pyrogens

For stimulation immune system for syphilis, a biogenic preparation is used Pyrogenal. Close in action to Pyrogenal is a drug Prodigiosan.

2. Interferon preparations

In early forms of syphilis, patients have impaired production of interferons. Their production is reduced by 2-5 times. The immune system can be improved domestic drug Amiksin, which is an oral inducer of endogenous interferon. When applied Amiksina regression of syphilides and negativity of CSR (a complex of serological reactions) occurs faster.

3. Immunocorrection of the T-cell link of immunity

Preparations of this group stimulate the work of lymphocytes and phagocytes. These include Timalin, Taktivin, Timogen, Immunomax and Imunofan.

4. Stimulants of phagocytosis

Stimulate phagocytosis and antibody production such drugs as Polyoxidonium, Likopid, Galavit, Methyluracil, Levamisole and etc.

5. Enzyme therapy

Under the influence of systemic enzymes, microcirculation and tissue trophism improve, toxins are removed, the concentration of antibiotics in inflammation foci increases, and the immune system is stimulated. Application Shown Wobenzina, Phlogenzyma, Wobe-Mugos E.

6. Vitamin therapy

Patients with syphilis are shown taking ascorbic acid, vitamins of group B.

7. Adaptogens

In order to increase the nonspecific resistance of the body, it is recommended to take adaptogens: Pantocrine, Rhodiola rosea and Eleutherococcus extract, Ginseng and lemongrass tincture.

8. Biogenic stimulants

Stimulate the protective functions of the body, metabolism and activate the processes of regeneration biogenic stimulators: FIBS, Placenta Extract, Plasmol, Splenin, Polybiolin.

Rice. 5. Hard chancre (hard ulcer) of the lower lip before treatment (left photo) and 14 days after treatment (right photo).

Physiotherapy treatment

To achieve the best effect in the treatment of syphilis, physiotherapy is prescribed.

1. Inductothermy

Inductothermy is a type of electrotherapy. The technique is based on the use of a high-frequency magnetic field. In patients with syphilis, it is recommended to use inductothermy

Preventive (warning) treatment is carried out for persons who were in the lumbar region and combined with taking a centrally acting drug Etimizole. A drug Etimizol acts on the pituitary gland, which leads to an increase in glucocorticosteroids in the blood plasma.

Magnetotherapy in patients with syphilis is used to obtain a restorative effect. Inductors are recommended to be placed along the spine.

3. Microwave therapy

This type of physiotherapy is used to improve the functional state of the nervous system, enhance local blood circulation, increase the level of metabolism and the body's defenses. Procedures are released sequentially on the epigastric region and thyroid gland on the first day and the epigastric and adrenal region on the second day.

4. Laser therapy

Laser therapy for syphilis is used to correct cellular and humoral immunity.

Rice. 6. Magnetotherapy.

Local treatment of syphilis

Giant ulcerative chancres, wide condylomas and pustular-ulcerative syphilides with syphilis are subject to local treatment. It is shown to use a 0.05% solution of chlorhexidine bigluconate or a 50-70% solution of dimexide in saline containing 100 thousand units in 1 milliliter. penicillin.

Lotions are applied until complete epithelialization or scarring of syphilides occurs.

Dense lymphoid infiltrates at the base of syphilides are lubricated with heparin ointment or a mixture containing podophyllin, dimethyl sulfoxide solution and glycerin in a ratio of 1:5:5.

The use of a helium-neon laser has a beneficial effect on the resorption of lymphoid infiltrates, scarring of hard ulcers (chancres) and wide condylomas, and the time for sanitation of syphilitic ulcers is shortened.

Rice. 7. Ulcerative chancres and wide warts are subject to local treatment.

Rice. 8. Pustular-ulcerative syphilides of the secondary period of syphilis.

Preventive treatment

Preventive (preventive) treatment is carried out for persons who had sexual or close household contact with patients with infectious forms of the disease, who did not show signs of syphilis and no more than 3 months have passed since the contact. Preventive treatment is given to persons who have received infected blood.

Treatment regimens

Preventive treatment is carried out for 14 days with water-soluble penicillin or penicillin novocaine salt. Most often, preventive treatment is carried out on an outpatient basis with the use of durant drugs:

• Extencillin or Retarpen in a single dose of 2.4 million units. once a week. The course of treatment is 3 injections.
• Bicillin-1, 3, 5. 4 injections are enough for the course - 2 injections per week. Bicillin-1 and 5 in a single dose of 1.5 million. units, Bicillin-3- in a single dose of 1.8 million units.

Surveillance and control

• If from the moment of contact has passed from 3 to 6 months, then the patient is monitored and monitored using a complex of serological reactions, RIT or RIF. The survey is carried out twice with an interval of two months. Together with serological control, a general clinical examination is always carried out.
• If more than 6 months have passed since the contact, then the serological test is carried out only once.
• Patients who have been transfused with infected blood are examined quarterly for one year.
• Persons who have had gonorrhea or others, and the source of infection has not been identified, are subject to a follow-up examination once a quarter for 6 months.
• Persons subjected to sexual violence are examined according to the same scheme.
• If persons who have been in close household or sexual contact with patients with early forms of syphilis have undergone preventive treatment, then they are not subject to further observation, or are examined once every three months.

Rice. 9. Congenital syphilis.