Some facts about the product:

Instructions for use

Price in the online pharmacy site: from 708

Pharmacological properties

Vilprafen Solutab is an antibiotic agent belonging to the group of macrolides. The drug has a bacteriostatic quality, which is characterized by a slowdown in the synthesis of protein substances of bacterial forms. If a significant amount of the drug is introduced into the site of the inflammatory process, then a bactericidal effect occurs.

After entering the body, the drug is rapidly absorbed by the walls of the gastrointestinal tract. The main substance of josamycin accumulates in the tissue structures of the lungs, lymph, dermatological and urinary biosystems. The product is able to biotransform in the hepatic organ to little active metabolites. The chemical component is excreted from the body with urine and bile.

Composition and form of release

The structure of Vilprafen Solutab includes the compound josamycin. Also, the product is filled with microcrystalline cellulose, polysorbate, magnesium stearate, macrogol 6000 and other materials. The drug is available in the form of tablets. The product can be purchased in suspension form. Which type of product is more suitable for the patient, the doctor will determine.

Indications for use

The drug is used to treat tonsillitis, sinusitis, diphtheria, scarlet fever, pharyngitis, severe bronchitis, laryngitis, whooping cough. Also, the product is prescribed for infection of soft tissue structures, dermis, infection with bacterial forms, urinary, genital organs - prostatitis, gonorrhea, urethritis. It is possible to administer tablets during infection oral cavity.

The doctor has the right to make an appointment, taking into account the individual characteristics of the body, information obtained as a result of a medical examination, clinical picture diseases. It is dangerous to take Vilprafen Solutab on your own, without a doctor's examination.

International Classification of Diseases (ICD-10)

A22 Carbuncle, malignant; A36.9 Diphtheria, type unspecified; A37 Pertussis; A38 Scarlet fever; A46 Erysipelas; A49.3 Mycoplasma infection, type unspecified; A53.9 Syphilis, type unspecified; A54.9 Gonococcal infection, type unspecified; A55 Chlamydial lymphogranuloma (venereal); A56 Other chlamydial pathologies that develop due to the penetration of bacteria into the genitals; A63.8 Other specified pathologies that develop due to the penetration of bacteria into the genital organs; A70 Chlamydia psittaci infection; A74.9 Chlamydia infection, type unspecified; H01.0 Inflammatory processes occurring in the structure of the eyelid; H04.3 Acute and unspecified inflammation of lacrimal passages; H66.9 Otitis media, type unspecified; I88 Nonspecific lymphadenitis; I89.1 Lymphangitis; J01 Acute sinusitis; J02.9 Acute pharyngitis, type unspecified; J03.9 Acute tonsillitis, type unspecified (tonsillitis, agranulocytic); J04.0 Acute laryngitis; J18 Pneumonia without specification of the pathogen; J20 Acute bronchitis; J31.2 Inflammation of the pharynx in a protracted form; J32 Inflammation of the paranasal sinuses in a protracted form; J37.0 Protracted laryngitis; J42 Protracted bronchitis, type unspecified; K05 Gingivitis and periodontal disease; L02 Dermal abscess, furuncle and carbuncle; L04 Acute lymphadenitis; L08.0 Pyoderma; L70 Acne; N34 Urethritis and urethral syndrome; N39.0 Infection of the urinary passages without an established focus of development; N41.0 Acute prostatitis; N41.1 Protracted prostatitis; N74.2 Inflammatory pathologies of female pelvic organs due to syphilis (A51.4+, A52.7+)

Side effects

When using the drug Vilprafen solutab, accidental symptoms often occur, manifested in the form of nausea, jaundice, diarrhea, certain types of colitis, and skin rashes. Sometimes there is a hearing loss. If you find these or other painful symptoms, you should immediately stop taking the tablets and consult a doctor. He will reduce the dosage, or change the therapy regimen.

Contraindications

Antimicrobial drugs can pose a danger to the human body. Therefore, they are used only after the appointment of a medical specialist. Otherwise, such therapy will lead to complications and the development of severe pathological processes. Before using the substance, a medical examination should be carried out. Before the introduction of tablets, it is recommended to study the instructions for the medication, its indications and contraindications. The list of the latter includes: severe dysfunctions of the hepatic organ, increased sensitivity of the immune mechanism to the chemical components of the product. In the presence of at least one of the above indications, it is prohibited to prescribe the remedy.

Application during pregnancy

It is not advisable to use an antibiotic of this group of medicines during gestation. It is prescribed in the most extreme cases, when the maximum benefit for the woman and the minimum risk of complications for the baby are expected. During this period, the pregnant patient should be under the supervision of a doctor.

Method and features of application

The tool can be taken by both adults and minors who are already 14 years old. Enter 1-2 tablets in several doses. The initial dosage should not exceed 1 g. To obtain good results in the treatment of chlamydia, it is recommended to take 500 mg of Vilprafen Solutaba 2 times every 24 hours for 2 weeks. As for the treatment of rosacea, in this case, they use 1000 mg, after dividing the drug into several doses. Course duration - no more than 10 days. The substance is allowed to be administered in various ways - taking a tablet form together with water, or after its preliminary dissolution in a liquid. Mix the resulting mixture well and drink immediately. The latter method is most often taken by people who have difficulty swallowing solid foods. Pills are not desirable to chew. The instruction indicates the need to use the product between meals. The josamycin compound is not prescribed to premature infants. It is possible to administer the drug to newborn babies. In this case, the work of the hepatic organization should be carefully monitored. A patient suffering from insufficient kidney function should pay attention to dosage adjustments. It needs to be aligned with the QC indicators. The drug is prohibited to prescribe in the presence of severe violations of the hepatic organ. How to administer pills to elderly people, the expert will point out.

Interaction with other drugs

Vilprafen solutab, as a substance with a bacteriostatic effect, is able to reduce the degree of this effect of other antimicrobial products. It is especially reflected in the influence of cephalosporin and penicillin compounds. If you enter the drug together with lincomycin, then there is a decrease in the effectiveness of both materials. Josamycin inhibits the elimination of theophylline, astemizole, terfenadine from the body. This combination can provoke a dangerous arrhythmia, which often leads to lethal outcome. According to some reports, the drug is able to increase the vasoconstructive effect when interacting with ergot alkaloids. If Vilprafen Solutab is administered together with a cyclosporine compound, then an increase in the amount of the latter in the blood substance is possible, up to nephrotoxic manifestations. The doctor needs to be informed about the intake of pharmacological agents. Based on the information received from the patient, he will suggest the optimal therapy regimen.

Overdose

There is no information about taking overdoses of the drug Vilprafen Solutab. Medical specialists pay attention to the possibility of accidental reactions when a significant amount of the agent is introduced into the body. In case of overdose and the occurrence of painful symptoms, you should immediately stop using the substance and consult a doctor. He will prescribe the appropriate therapy.

Analogues

Means alternative to the product are not sold in pharmacies. Therefore, only a medical specialist can replace the drug. Based on the data obtained after a medical examination, clinical indications, information about the individual characteristics of the patient, the expert will change the treatment regimen and prescribe other medications. Substances similar in their actions belong to the group of macrolides. Among them, materials such as spiramycin, azithromycin, erythromycin and other antimicrobial chemical components are distinguished. The cost of products depends on many factors. The price of an analogue can be either less or more than Vilprafen Solutab. The drug without the second part of the name has some differences. First of all, we are talking about the form of release. It is a more simplified version - ordinary tablets, coated on top with a special shell. As for the additional word solutab, this type of medicine is a soluble substance with a pleasant taste and aroma. It is from them that it is very easy to prepare a suspension. In this case, all the rules of sterility should be followed.

Terms of sale

Vilprafen Solutab is sold by prescription from a doctor.

Storage conditions

The tool is included in list B. Instructions for use indicate the features of saving the product. It should be kept in a dark place that is not accessible to minors and sunlight. The temperature regime should not exceed 25°C. The product must not be frozen. Shelf life - 4 years from the date of release of the drug. If defects or other damage are found on the packaging, the tablets must be disposed of immediately.

Vilprafen solutab (form - tablets) belongs to the group antimicrobials for systemic use. Important Features medicines from the instructions for use:

• Sold by prescription only
• During pregnancy: with caution
• When breastfeeding: with caution
• V childhood: carefully
• For violations of liver function: contraindicated
• In case of impaired renal function: with caution

Package

Vilprafen Solutab - official instruction by application

Prices / buyAnalogues, articlesComments

IndicationsContraindicationsDosageWarningsInteractionsManufacturer

INSTRUCTIONS

(information for specialists)

on medical use drug

Wilprafen Solutab

Registration number:

Trade name: VILPRAFEN SOLUTAB

International nonproprietary name (INN): Josamycin

Dosage form: dispersible tablets

Composition per 1 tablet

Active substance:

Josamycin - 1000 mg (which is equivalent to josamycin propionate) - 1067.66 mg.

Excipients:

Microcrystalline cellulose - 564.53 mg, hyprolose - 199.82 mg, docusate sodium - 10.02 mg, aspartame - 10.09 mg, colloidal silicon dioxide - 2.91 mg, strawberry flavor - 50.05 mg, magnesium stearate - 34.92 mg.

Description:

White or white with a yellowish tint, oblong-shaped tablets, sweet, with a strawberry smell. With the inscription "JOSA" and a notch on one side of the tablet and the inscription "1000" on the other.

Pharmacotherapeutic group: antibiotic, macrolide.

ATC code: J01FA07

Pharmacological properties

Pharmacodynamics.

The drug is used to treat bacterial infections; The bacteriostatic activity of josamycin, like other macrolides, is due to the inhibition of bacterial protein synthesis. When creating high concentrations in the focus of inflammation, it has a bactericidal effect.

Josamycin is highly active against intracellular microorganisms (Chlamydia trachomatis and Chlamydia pneumoniae, Mycoplasma pneumoniae, Mycoplasma hominis, Ureaplasma urealyticum, Legionella pneumophila); gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae (pneumococcus), Corynebacterium diphteriae), gram-negative bacteria (Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis), and also against some anaerobic bacteria (Peptococcus, Peptostreptococcus, Clostridium perfringium). Slightly affects enterobacteria, therefore little changes the natural bacterial flora gastrointestinal tract. Effective with resistance to erythromycin. Resistance to josamycin develops less frequently than to other macrolide antibiotics.

Pharmacokinetics.

After oral administration, josamycin is rapidly and completely absorbed from the gastrointestinal tract, food intake does not affect bioavailability. The maximum concentration of josamycin in serum is reached 1-2 hours after administration. About 15% of josamycin binds to plasma proteins. Particularly high concentrations of the substance are found in the lungs, tonsils, saliva, sweat and lacrimal fluid. The concentration in sputum exceeds the concentration in plasma by 8-9 times. accumulates in bone tissue. Crosses the placental barrier, secreted into breast milk. Josamycin is metabolized in the liver to less active metabolites and excreted mainly in the bile. Urinary excretion of the drug is less than 20%.

Indications for use

Acute and chronic infections caused by susceptible organisms, such as:

Upper infections respiratory tract and ENT organs:

Angina, pharyngitis, paratonsillitis, laryngitis, otitis media, sinusitis, diphtheria (in addition to treatment with diphtheria toxoid), as well as scarlet fever in case of hypersensitivity to penicillin.

Lower respiratory tract infections:

Acute bronchitis, exacerbation chronic bronchitis, pneumonia (including those caused by atypical pathogens), whooping cough, psittacosis.

dental infections

Gingivitis and periodontal disease. Infections in ophthalmology Blepharitis, dacryocystitis.

Skin and soft tissue infections

Pyoderma, furunculosis, anthrax, erysipelas (with increased sensitivity to penicillin), acne, lymphangitis, lymphadenitis, lymphogranuloma venereum.

Urinary tract infections

Prostatitis, urethritis, gonorrhea, syphilis (with hypersensitivity to penicillin), chlamydia, mycoplasma (including ureaplasma) and mixed infections.

Contraindications

hypersensitivity to macrolide antibiotics severe liver dysfunction

Pregnancy and lactation

Approved for use during pregnancy and during breastfeeding after medical benefit/risk evaluation. The WHO European Office recommends josamycin as the drug of choice for the treatment of chlamydial infection in pregnant women.

Dosage and administration

The recommended daily dosage for adults and adolescents over 14 years of age is 1 to 2 g of josamycin. The daily dose should be divided into 2-3 doses. If necessary, the dose can be increased to 3 g per day.

Children aged 1 year have an average body weight of 10 kg.

The daily dosage for children weighing at least 10 kg is prescribed based on the calculation of 40-50 mg / kg body weight daily, divided into 2-3 doses: for children weighing 10-20 kg, the drug is prescribed 250-500 mg ( 1/4-1/2 tablets dissolved in water) 2 times a day, for children weighing 20-40 kg, the drug is prescribed 500 mg-1000 mg (1/2 tablet -1 tablet dissolved in water) 2 times per day, more than 40 kg - 1000 mg (1 tablet) 2 times a day.

Usually the duration of treatment is determined by the doctor. In accordance with the recommendations of the World Health Organization on the use of antibiotics, the duration of treatment for streptococcal infections should be at least 10 days.

In anti-Helicobacter therapy regimens, josamycin is prescribed at a dose of 1 g 2 times a day for 7-14 days in combination with other drugs in their standard dosages (famotidine 40 mg / day or ranitidine 150 mg 2 r / day + josamycin 1 g 2 r / day day + metronidazole 500 mg twice daily; omeprazole 20 mg (or lansoprazole 30 mg or pantoprazole 40 mg or esomeprazole 20 mg or rabeprazole 20 mg) twice daily + amoxicillin 1 g twice daily + josamycin 1 g 2 r/day; omeprazole 20 mg (or lansoprazole 30 mg, or pantoprazole 40 mg, or esomeprazole 20 mg, or rabeprazole 20 mg) bid + amoxicillin 1 g bid + josamycin 1 g bid + bismuth tripotassium dicitrate 240 mg 2 r/day: famotidine 40 mg/day + furazolidone 100 mg 2 r/day + josamycin 1 g 2 r/day + bismuth tripotassium dicitrate 240 mg 2 r/day).

In the presence of atrophy of the gastric mucosa with achlorhydria, confirmed by pH-metry: Amoxicillin 1 g 2 r / day + josamycin 1 g 2 r / day + tripotassium bismuth d and citrate 240 mg 2 r / day.

In the case of acne vulgaris and globulus, it is recommended to prescribe josamycin at a dose of 500 mg twice a day for the first 2-4 weeks, followed by 500 mg of josamycin once a day as maintenance treatment for 8 weeks.

Dispersible tablets Vilprafen Solutab can be taken in various ways: the tablet can be swallowed whole with water or previously dissolved in water before taking. Tablets should be dissolved in at least 20 ml of water. Before taking, mix the resulting suspension thoroughly.

Impact on ability to drive vehicles and work with mechanisms

There was no effect of the drug on the ability to drive vehicles and work with mechanisms.

Side effect

From the gastrointestinal tract

Rarely - loss of appetite, nausea, heartburn, vomiting, dysbacteriosis and diarrhea. In the case of persistent severe diarrhea, one should keep in mind the possibility of developing life-threatening pseudomembranous colitis against the background of antibiotics.

Hypersensitivity reactions:

In extremely rare cases skin allergic reactions (for example, urticaria) are possible.

From the side of the liver and biliary tract

In some cases, a transient increase in the activity of liver enzymes in the blood plasma was observed, in rare cases accompanied by a violation of the outflow of bile and jaundice.

From the side of the hearing aid

In rare cases, dose-dependent transient hearing loss has been reported.

Others: very rarely - candidiasis.

Overdose and other mistakes when taking

To date, there are no data on specific symptoms of poisoning. In case of overdose, the occurrence of the symptoms described in the "Side Effects" section should be expected, especially from the gastrointestinal tract. If one dose is missed, you must immediately take a dose of the drug. However, if it is time for the next dose, do not take the "forgotten" dose, but return to the usual treatment regimen. Do not double the dose. Interruption in treatment or premature discontinuation of the drug reduces the likelihood of treatment success.

Interaction with other drugs

Vilprafen Solutab / other antibiotics

Since bacteriostatic antibiotics may reduce the bactericidal effect of other antibiotics such as penicillins and cephalosporins, co-administration of josamycin with these types of antibiotics should be avoided. Josamycin should not be co-administered with lincomycin, as there may be a mutual decrease in their effectiveness.

Vilprafen Solutab / xanthines

Some representatives of macrolide antibiotics slow down the elimination of xanthines (theophylline), which can lead to possible intoxication. Clinical and experimental studies indicate that josamycin has less effect on theophylline release than other macrolide antibiotics.

Vilprafen Solutab / antihistamines

After the joint appointment of josamycin and antihistamines containing terfenadine or astemizole, there may be a slowdown in the excretion of terfenadine and astemizole, which in turn can lead to the development of life-threatening cardiac arrhythmias.

Vilprafen Solutab / ergot alkaloids

There are individual reports of increased vasoconstriction after the co-administration of ergot alkaloids and macrolide antibiotics. There has been one case of ergotamine intolerance in a patient while taking josamycin. Therefore, the concomitant use of josamycin and ergotamine should be accompanied by appropriate monitoring of patients.

Vilprafen Solutab / cyclosporine

Co-administration of josamycin and cyclosporine can cause an increase in the level of cyclosporine in the blood plasma and the creation of a nephrotoxic concentration of cyclosporine in the blood. Plasma concentrations of cyclosporine should be regularly monitored.

Vilprafen Solutab / digoxin

With the joint appointment of josamycin and digoxin, an increase in the level of the latter in the blood plasma is possible.

Vilprafen Solutab / hormonal contraceptives

In rare cases, the contraceptive effect of hormonal contraceptives may be insufficient during treatment with macrolides. In this case, it is recommended to additionally use non-hormonal contraceptives.

special instructions

In patients with kidney failure treatment should be based on the results of appropriate laboratory tests.

Consideration should be given to the possibility of cross-resistance to various macrolide antibiotics (eg, organisms resistant to treatment with chemically related antibiotics may also be resistant to josamycin).

Release form: dispersible tablets 1000 mg.

Standard Packing:

5 or 6 dispersible tablets in a blister made of PVC film and aluminum foil. 2 blisters with instructions for use in a cardboard box.

Shelf life: 2 years

Vilprafen Solutab should not be used after the expiry date which is stated on the package.

Storage conditions

List B.

Store in a dry, dark place at a temperature not exceeding 25°C.

Keep the medicine out of the reach of children!

Terms of dispensing from pharmacies

Released by prescription

Registration applicant (registration holder)

Astsllas Pharma Europe B.V., Elizabethof 19, 2353 EB Leiderdorp,

Netherlands / Astellas Pharma Europe B.V.,

Elisabethhof 19.2353 EW Leiderdorp, The Netherlands.

Manufacturer:

Montefarmaco S.

Italy/Montefarmaco S.p.A.

Via Galilei, n.7, 20016 Pero (MI), Italy

Packer (primary packaging)

Montefarmaco S.p.A., Italy

Packer (secondary/tertiary packaging)

Montefarmaco S.p.A., Italy or Temmler Italia S.rL., Italy

Issuing quality control

Temmler Italia S.r.L., Italy

Subject to packaging at ORTAT CJSC

Manufacturer Montefarmaco S.

Italy/Montefarmaco S.p.A. Via Galilei, n.7,20016 Pero (MG), Italia

Packer and release control

ZAO ORTAT, Russia

157092, Kostroma region, Susaninsky

district, s. Northern, m-n Kharitonovo.

Claims should be sent to the Moscow Representative Office of Astellas

Pharma Yuroy B.V. by the address:

109147 Moscow, Marksistskaya st. sixteen,

"Mosalarko Plaza-1" business center,

The macrolide antibiotic is Vilprafen. Instructions for use indicate that 500 mg and 1000 mg tablets of Solutab have bactericidal and bacteriostatic properties. According to doctors, this drug helps in the treatment of ureaplasmosis, chlamydia, bronchitis, pneumonia and other infections.

Release form and composition

The drug is produced in the form of coated tablets. The blister pack contains 10 such tablets. The packaging is enclosed in a cardboard box.

Also, the drug is available in the form of a suspension. It is contained in dark glass bottles, 100 ml per bottle. The kit includes a measuring cup.

The composition of Vilprafen is as follows:

• one tablet contains 500 mg of josamycin or 1000 mg (Vilprafen Solutab);
• suspension (10 ml) contains 300 mg of josamycin.

Indications for use

What helps Vilprafen (Solutab)? Tablets are prescribed:

• People with hypersensitivity to penicillin in scarlet fever.
• Infectious diseases that provoke inflammatory processes that were caused by microorganisms with high sensitivity to the drug.
• Infections of the skin and soft tissues (with boils, pyoderma, lymphadenitis, etc.)
• It is used in the treatment of diphtheria in addition to therapy with diphtheria antitoxin.
• Infections of the oral cavity (for periodontal disease, gingivitis).
• Infectious diseases of the upper respiratory tract and upper respiratory tract (used for tonsillitis, pharyngitis, tonsillitis, sinusitis, laryngitis, otitis media).
• lower respiratory infections (pneumonia, acute bronchitis whooping cough, bronchopneumonia).
• Infections of the genitourinary organs (with chlamydia, with ureaplasma, gonorrhea, urethritis, prostatitis, etc.)

Instructions for use

Vilprafen is taken in the recommended daily dose for adults and adolescents over the age of 14, which is 1-2 g, in 2-3 doses. If necessary, the dose can be increased to 3 g per day. Children aged 1 year have an average body weight of 10 kg.

The daily dose for children weighing at least 10 kg is prescribed based on the calculation of 40-50 mg / kg of body weight daily, divided into 2-3 doses:

• children weighing 10-20 kg are prescribed 250-500 mg (1/4-1/2 tablets dissolved in water) 2 times a day;
• children weighing 20-40 kg are prescribed 500-1000 mg (1/2-1 tablet dissolved in water) 2 times a day;
• children weighing over 40 kg - 1000 mg (1 tablet) 2 times a day.

Usually the duration of treatment is determined by the doctor and ranges from 5 to 21 days, depending on the nature and severity of the infection. In accordance with WHO recommendations, the duration of treatment for streptococcal tonsillitis should be at least 10 days.

In the schemes of antihelicobacter therapy, Vilprafen is prescribed at a dose of 1 g 2 times a day for 7-14 days in combination with other drugs in their standard doses:

• famotidine 40 mg daily or ranitidine 150 mg twice daily + josamycin 1 g twice daily + metronidazole 500 mg twice daily;
• omeprazole 20 mg (or lansoprazole 30 mg, or pantoprazole 40 mg, or esomeprazole 20 mg, or rabeprazole 20 mg) twice daily + amoxicillin 1 g twice daily + josamycin 1 g twice daily;
• omeprazole 20 mg (or lansoprazole 30 mg or pantoprazole 40 mg or esomeprazole 20 mg or rabeprazole 20 mg) twice daily + amoxicillin 1 g twice daily + josamycin 1 g twice daily + bismuth tripotassium dicitrate 240 mg 2 times a day;
• famotidine 40 mg daily + furazolidone 100 mg twice daily + josamycin 1 g twice daily + bismuth tripotassium dicitrate 240 mg twice daily).

In the presence of atrophy of the gastric mucosa with achlorhydria, confirmed by pH-metry: amoxicillin 1 g 2 times a day + josamycin 1 g 2 times a day + bismuth tripotassium dicitrate 240 mg 2 times a day.

The instruction to Vilprafen Solutab provides that the drug can be taken in different ways: you can take the tablet with water, or before dissolving in 20 ml of water. The suspension that formed after the dissolution of the tablet must be mixed very carefully.

Vilprafen tablets should be swallowed whole. Often patients are interested in how to take, before or after meals. The instructions indicate that the tablets must be swallowed between main meals.

When treating, it should be borne in mind that if one dose is missed, you must immediately take a dose of the drug. However, if it is time to take the next dose, you should not take the missed dose, you should return to the usual treatment regimen. Do not double dose. Interruption in treatment or premature discontinuation of the drug reduces the likelihood of success of therapy.

pharmachologic effect

The drug is an antibiotic that belongs to the group of macroliths. The bacteriostatic effect of the drug is due to the inhibition of protein synthesis by bacteria. If there are foci of inflammation, the drug has a bactericidal effect.

Vilprafen is highly effective against such intracellular microorganisms as Mycoplasma pneumoniae, Ureaplasma urealyticum, Chlamydia trachomatis, Legionella pneumophila, Chlamydia pneumonuae, Mycoplasma hominis.

High activity is also observed against gram-negative aerobic bacteria:

• Haemophilus influenzae, Neisseria meningitidis, Neisseria gonorrhoeae, Bordetella pertussis;
• gram-positive aerobic bacteria: Streptococcus pyogenes, Staphylococcus aureus, Corynebacterium diphtheriae, Streptococcus pneumoniae;
• anaerobic bacteria: Peptostreptococcus, Peptococcus, Clostridium perfringens.

The drug is effective against Treponema pallidum. The active substance of the drug is josamycin, which is completely and rapidly absorbed from the gastrointestinal tract.

Contraindications

Vilprafen is contraindicated in patients with the following conditions:

• Liver failure.
• Individual intolerance to the constituent components of the drug.
• Past severe allergic reactions to drugs from the macrolide group.
• Pregnancy and the period of breastfeeding.

Side effects

While taking Vilprafen, it is possible to develop disorders from various body systems:

• In severe persistent diarrhea, the possibility of pseudomembranous colitis (life-threatening) due to the action of an antibiotic should be borne in mind.
• Hypersensitivity reactions: in some cases - allergic skin reactions (eg, urticaria).
• Gastrointestinal tract: rarely - heartburn, nausea, loss of appetite, diarrhea and vomiting.
• Hearing aid: in rare cases, dose-dependent transient hearing loss.
• Biliary tract and liver: in some cases - a transient increase in the activity of liver enzymes in the blood plasma, sometimes accompanied by jaundice and a violation of the outflow of bile.

Children, during pregnancy and lactation

The drug is not prescribed for pregnant women if there are severe disorders in the liver, sensitivity to the constituent components.

In childhood

The drug is not prescribed to premature babies. Newborn patients with impaired liver function are treated under strict supervision.

Vilprafen for children under the age of 14 is used as a suspension.

Vilprafen 1000 mg Solutab can be dissolved in water to prepare a suspension. If treatment with the drug is prescribed for children, the dosage is as follows: 30-50 mg per 1 kg of body weight is divided into three doses.

Suspension for children up to three months of age is dosed according to the exact weight of the child. Why tablets are used, and whether they should be used for treatment, should be checked with a doctor.

special instructions

With the simultaneous appointment of Vilprafen with ergot alkaloids, vasoconstriction may increase. Therefore, in this case, careful monitoring of the patient's condition is necessary.

Simultaneous administration of josamycin and cyclosporine provokes an increase in the level of cyclosporine in the blood plasma. Also in the blood there is a nephrotoxic concentration of cyclosporine. With such treatment, it is necessary to ensure constant monitoring of plasma concentrations of cyclosporine.

drug interaction

If Vilprafen is administered simultaneously with antihistamines, which contain terfenadine or astemizole, the process of excretion of these substances sometimes slows down, which ultimately leads to the manifestation of life-threatening cardiac arrhythmias.

If you take Vilprafen and Digoxin at the same time, the level of digoxin in the blood plasma may increase.

Speaking about the interaction with other drugs, it should be borne in mind that Vilprafen is an antibiotic. Before using any medicinal product it is necessary to determine whether it is an antibiotic or not.

When taken with hormonal contraceptives, the effect of the latter may decrease. In such a situation, the use of additional non-hormonal contraceptives is recommended.

With the development of pseudomembranous colitis, Vilprafen should be discontinued and appropriate treatment prescribed. It is contraindicated to take drugs that reduce intestinal motility. Patients with renal insufficiency need to adjust the dosing regimen in accordance with the values ​​of creatinine clearance (CC).

According to the instructions, Vilprafen is not prescribed to premature babies. When used in newborns, liver function should be monitored. It is necessary to take into account the possibility of cross-resistance to various antibiotic drugs of the macrolide group.

Vilprafen's analogs

According to the structure, analogues are determined:

1. Wilprafen Solutab.
2. Josamycin.

Analogues that belong to the group of macrolides have a similar effect:

1. Roxithromycin.
2. Spiramycin.

Often patients are interested in how Vilprafen differs from Vilprafen Solutab. What is the difference between these drugs, due to their form of release.

Vilprafen is a conventional film-coated tablet. Solutab are soluble tablets that have a sweet taste and fruity aroma. They can be taken both in the form of tablets and in the form of a suspension.

Quick page navigation

Vilprafen Solutab is a dispersible tablet that belongs to the macrolide class of antibacterial agents. This original drug is produced by the Italian company Montefarmaco S, but the applicant for registration is the Dutch pharmaceutical concern Astellas Pharm Europe.

Vilprafen Solutab is available in the form of a solid dosage form - soluble tablets of white or yellowish color. They have an oblong oval shape, in the middle of the tablet there is a risk for dividing the drug into equal parts. On one side of the surface of the tablet there is the inscription "IOSA", and on the other - 1000, which corresponds to the amount of the active substance josamycin.

The drug is packed in blisters for 5 cells and sold in a cardboard box of 5 or 10 tablets. The active ingredient is part of Vilprofen Solutab 1000 mg in the form of a salt - josamycin propionate. Auxiliary agents in the tablet are microcrystalline cellulose, weakly substituted hydroxypropyl cellulose, docusate sodium, aerosil, aspartame (E951), magnesium stearate, strawberry flavor.

Josamycin belongs to the macrolide class of antibiotics, which has a wide spectrum of action and has a bacteriostatic effect. The bactericidal effect is on microorganisms that are highly sensitive to the active substance.

Wilprafen Solutab 1000 photo

The mechanism of action of the drug is due to reversible binding to the 50S ribosome of the microorganism, which inhibits the synthesis of proteins in the bacterial cell and causes inhibition of its growth.

An important feature medicinal substance is its ability to influence the intracellular forms of microorganisms.

What helps Vilprafen Solutab?

Microorganisms sensitive to the drug are various types of staphylococci (including those producing beta-lactamase), streptococci various kinds, anthrax bacilli, corynebacterium diphtheria, gonococci, meningococci, shigella, haemophilus influenzae, whooping cough, legionella, mycoplasma, chlamydia, treponema (pathogens of syphilis), rickettsia, some anaerobic bacteria and fungi (Peptococcus spp, Bacteroides spp, Peptostreptococcus). .

Based on such a great therapeutic activity, it is possible to answer the question of what Vilprafen Solutab helps from:

• Infectious diseases of the respiratory system and ENT organs (gingivitis, sinusitis, otitis media, laryngitis, pharyngitis, bronchitis, pneumonia, whooping cough, psittacosis);
• Diseases of the urinary and genital infectious genesis: prostatitis, gonorrhea, urethritis, chlamydia, syphilis, mycoplasmosis, ureaplasmosis;
• Bacterial skin lesions: pyoderma, acne, furunculosis, lymphadenitis, erysipelas, anthrax;
• Eye diseases (inflammation in the eyelids or nasolacrimal canal of infectious etiology);
• Other specific diseases: diphtheria, dysentery, scarlet fever, etc.

A special advantage of the drug is the possibility of its use in children in the treatment of bacterial infections of the respiratory tract, due to its pleasant taste and convenient dosage form. Vilprafen Solutab has proven itself well in the treatment of community-acquired pneumonia, especially in people with hypersensitivity to penicillins.

Vilprafen solutab is successfully used for the treatment of bacterial diseases of the reproductive system, which threaten the loss of reproductive function, miscarriages and intrauterine infection of the fetus. Josamycin has much less side effects than other antibiotics, and it is also less likely to cause the formation of resistant strains.

Instructions for use Vilprafen Solutab, dosage

According to the instructions for use of Vilprafen Solutab 500 \ 1000 - the maximum daily dose the drug is 3 g, they are divided into 2-3 doses per day. Usually, therapy is carried out at the rate of 1.5-2 g of josamycin per day.

Tablets can be swallowed with plain water, without chewing, or dissolved in a small amount of liquid (at least 1 tablespoon of water). The drug is used before or after meals.

• The duration of the course is determined by the attending physician, depending on the pathogen and the patient's condition, it can last from five days to three weeks.

The instructions indicate that for children from 1 year old, Vilprafen Solutab is prescribed based on the weight of the child, while his body weight should not be less than 10 kg. For 1 kg of the child's body, 40-50 mg of the drug is prescribed per day and the resulting dosage is divided into 2-3 doses.

With a body weight of more than 40 kg, the drug is taken in an adult dosage.

special instructions

Taking Vilprafen Solutab may affect the effect of certain drugs:

• Taking this macrolide with some antiallergic drugs (terfenadine, astemizole) leads to life-threatening arrhythmias.
• Slowing down the excretion of xanthines while taking josamycin can lead to theophylline intoxication.
• At combined application Vilprafen with ergot alkaloids may cause severe vasoconstriction.
• An increase in nephrotoxicity is caused by the combined use of josamycin and cyclosporine.
• Taking the drug with bactericidal agents inhibits the activity of the active substance.

The drug does not affect the ability to drive vehicles.

Side effects Wilprafen Solutab, contraindications

The most common side effects are abdominal pain, nausea, and allergies (urticaria and other skin reactions). Much less common are constipation, diarrhea, problems with appetite, and vomiting. There is a possibility of developing pseudomembranous colitis. Manifestations of hepatic dysfunction and jaundice are possible. Taking high doses of the drug can lead to hearing loss.

Contraindications to the use of Vilprafen Solutab tablets are:

• age up to 1 year;
• weight less than 10 kg;
• the presence of liver failure;
• allergic reactions to the components of the drug;
• history of hypersensitivity to other macrolides.

During pregnancy and lactation, taking the drug is not contraindicated, but this requires clear indications and a balanced decision by the doctor. So far, nothing has been reported about cases of overdose of the drug, so there is no specific antidote and it is assumed symptomatic treatment on the background of detoxification therapy.

Vilprafen Solutab analogs, list of drugs

To date, among the analogues of Vilprafen Solutab there is only one drug - Vilprafen, it is produced by the same pharmaceutical company.

What is better Vilprafen or Vilprafen Solutab?

Vilprafen Solutab tablets differ from Vilprafen tablets in their solubility, which significantly affects the pharmacokinetics of the drug.

The use of Solutab technology provides better bioavailability of the active ingredient. It is achieved due to the uniform distribution of microparticles in the stomach and the controlled release of josamycin as water penetrates into the microparticles. Complete release occurs in the "window of reabsorption" - the duodenum.

Also, the difference between the two forms of the drug is the dosage - 1000 mg and 500 mg, respectively, so Vilprafen Solutab can be used less frequently, which significantly reduces the risk of side effects.

The dispersible tablet form has a pleasant taste and is easy to give to children from as early as 1 year of age. In addition, the cost of treatment with Vilprafen Solutab is approximately 30% cheaper than with Vilprafen alone. Thus, it is safe to say that the soluble form of tablets is much better and more convenient.

Vilprafen Solutab is a modern antibacterial agent with a wide spectrum of action, which can be used according to indications even for children and during pregnancy. The drug is easy to take, has few side effects and a low chance of developing resistant strains. The effectiveness of the drug is very high and clinically proven.

In addition, Vilprafen contains auxiliary ingredients: microcrystalline cellulose , methylcellulose , polysorbate 80 , silica colloidal anhydrous , sodium carboxymethyl cellulose , magnesium stearate , talc , titanium dioxide (E171) , macrogol 6000 , poly(ethacrylate methyl methacrylate) -30% , aluminum hydroxide .

Release form

The drug is produced in the form of coated tablets. The blister pack contains 10 such tablets. The packaging is enclosed in a cardboard box. How many tablets are in the package, so many are in the pack.

Also, the drug is available in the form of a suspension. It is contained in dark glass bottles, 100 ml per bottle. The kit includes a measuring cup. Suspension in a vial is contained in a cardboard box.

Candles with this active ingredient are also produced.

pharmachologic effect

The tool is, which belongs to the group of macrolides. It has a bacteriostatic effect on the body, which is produced due to the inhibition of protein synthesis by bacteria. If a high concentration of the drug is noted in the focus of the inflammatory process, it has a pronounced bactericidal effect.

The high activity of the active substance is noted in relation to a number of intracellular microorganisms: Chlamydia pneumoniae , Chlamydia trachomatis , Mycoplasma hominis , Mycoplasma pneumoniae , Legionella pneumophila , Ureaplasma urealyticum . Also, the drug affects gram-positive aerobic bacteria: Streptococcus pyogenes , Staphylococcus aureus , Corynebacterium diphtheriae , Streptococcus pneumoniae (pneumococcus) . Effects on Gram-negative aerobic bacteria haemophilus influenzae , Neisseria gonorrhoeae , Bordetella pertussis , Neisseria meningitidis and some anaerobic bacteria Peptostreptococcus , Clostridium perfringens , Peptococcus .

Vilprafen activity is noted in relation to Treponema pallidum .

Pharmacodynamics and pharmacokinetics

After oral intake there is a rapid absorption of the substance from the gastrointestinal tract. The highest concentration of the drug is reached 1-2 hours after ingestion. After 45 minutes after taking the drug at a dose of 1 g, the average concentration of josamycin in the blood plasma is 2.41 mg / l.

The active substance binds to blood proteins by no more than 15%. If the drug is taken at intervals of 12 hours, a sufficient concentration of josamycin remains in the tissues throughout the day. After 2-4 days, the balance of its content is reached.

Josamycin is able to easily penetrate membranes. It accumulates in the lymphatic, lung tissue, in the palatine tonsils, in the urinary organs, and also in soft tissues.

The highest concentration of the drug is observed in the tonsils, saliva, lungs, sweat, lacrimal fluid.

In the liver, biotransformation of josamycin occurs, as a result of which it turns into less active metabolites.

It is mainly excreted from the body with bile, less than 20% of the substance is excreted in the urine.

Indications for use

Before starting treatment, you should definitely consult a doctor and read the annotation, which describes what the pills are for.

Indications for use are as follows:

• Infectious diseases that provoke inflammatory processes that were caused by microorganisms with high sensitivity to the drug.
• Infectious diseases of the ENT organs and upper respiratory tract (used for, sinusitis , otitis media ).
• Lower respiratory tract infections (with pneumonia , sharp , bronchopneumonia ).
• Infections of the oral cavity (for diseases periodontal , gingivitis ).
• Infections of the skin and soft tissues (with boils , pyoderma , and etc.)
• Infections of the genitourinary organs (with, with, gonorrhea , and etc.)
• It is used in the treatment of diphtheria in addition to therapy with diphtheria antitoxin.
• People with hypersensitivity to penicillin are prescribed for.

Contraindications

You can not take the drug in the following cases:

• with hypersensitivity to antibiotics macrolides ;
• with severe violations in the functions of the liver.

Side effects

The following side effects when treated with this remedy:

• In functions digestive system: rarely observed manifestations of nausea, vomiting,. In severe persistent diarrhea, severe pseudomembranous colitis may develop due to the effect of antibiotics on the body.
• Hypersensitivity reactions rarely develop: allergic reactions on the skin are very rarely noted.
• In the functions of the liver and biliary tract: sometimes there is a transient increase in the activity of liver enzymes in the blood plasma, which may be accompanied by a violation of the outflow of bile, followed by jaundice .
• Rarely, dose-dependent hearing loss has been reported.

Application instruction of Vilprafen (Way and dosage)

Antibiotic is taken in the following way. Adults and adolescents who are already 14 years old take 1-2 g of the drug in two to three divided doses. It is recommended to start with a dose of 1 g.

In the treatment of chlamydia, 500 mg should be taken twice a day for 12-14 days. Rosacea therapy involves taking 1000 mg of the drug, which should be divided into two doses per day. Treatment continues for 10 days.

Dosage to be taken tablets in a number of other diseases, only the attending physician determines, taking into account the individual characteristics of the course of the disease. But basically the course of treatment lasts at least 10 days.

Instructions for Vilprafen Solutab provides that the drug can be taken in different ways: you can take a tablet with water, or before dissolving in 20 ml of water. The suspension that formed after the dissolution of the tablet must be mixed very carefully.

Vilprafen tablets must be swallowed whole. Often patients are interested in how to take, before or after meals. The instructions indicate that the tablets must be swallowed between main meals.

Overdose

To date, there is no data on overdose and symptoms of drug poisoning. If an overdose occurs, there may be those signs that are described as side effects of the drug.

Interaction

Speaking about the interaction with other drugs, it should be borne in mind that Vilprafen is an antibiotic. Before using any drug, it is imperative to determine whether it is an antibiotic or not.

If Vilprafen is administered simultaneously with antihistamines containing or astemizole , sometimes the process of excretion of these substances slows down, which ultimately leads to the manifestation of cardiac, life-threatening.

With the simultaneous appointment of Vilprafen with ergot alkaloids may increase vasoconstriction. Therefore, in this case, careful monitoring of the patient's condition is necessary.

Simultaneous administration of josamycin provokes an increase in the level of cyclosporine in the blood plasma. Also in the blood there is a nephrotoxic concentration of cyclosporine. With such treatment, it is necessary to ensure constant monitoring of plasma concentrations of cyclosporine.

If you take Vilprafen and at the same time, it may increase the level of digoxin in the blood plasma.

When taking Vilprafen with hormonal contraceptives may reduce the effect of the latter. In such a situation, the use of additional non-hormonal contraceptives is recommended.

Terms of sale

It is sold only by prescription.

Storage conditions

Refers to list B. Drugs should be stored in a dark place, at a temperature not exceeding 25°C. The drug must be protected from children.

Best before date

Vilprafen can be stored for 4 years.

special instructions

People suffering kidney failure , it is necessary to take into account the results of laboratory tests in the treatment.

It is necessary to take into account the possibility of resistance to various macrolide antibiotics.

Analogues

Coincidence in the ATX code of the 4th level:

Vilprafen's analogs of 500 mg having the same active substance are not sold in pharmacies. What can replace this drug, only a doctor should determine. The substitute is selected taking into account the individual characteristics of the course of the disease.

Analogues of the drug are drugs that belong to the group of macrolides. This group includes erythromycin , clarithromycin , azithromycin , roxithromycin , spiramycin . The price of analogues can be either higher or lower than the cost of Vilprafen. Vilprafen Solutab analogues are similar.

Patients often ask what Wilprafen differs from Vilprafen Solutab. What is the difference between these drugs, due to their form of release. Vilprafen is a conventional film-coated tablet. Vilprafen Solutab are soluble tablets that have a sweet taste and fruity aroma. They can be taken both in the form of tablets and in the form of a suspension.

Synonyms

Josamycin .

children

Vilprafen for children under the age of 14 is used as a suspension. Vilprafen 1000 mg Solutab can be dissolved in water to prepare a suspension. If treatment with the drug is prescribed for children, the dosage is as follows: 30-50 mg per 1 kg of body weight is divided into three doses. Suspension for children up to three months of age is dosed according to the exact weight of the child. Why tablets are used, and whether they should be used for treatment, should be checked with a doctor.

With alcohol

If alcohol and Vilprafen are combined, then as a result, a person may experience a variety of disorders in the digestive system. Alcohol and antibiotics, when combined, can provoke the manifestation of a hepatotoxic effect. In addition, such a combination can become a trigger for the development of liver cirrhosis. Even once you should not combine Vilprafen and alcohol, since when used together with alcohol, the reviews indicate that a person's well-being may worsen.

With antibiotics

Do not prescribe josamycin simultaneously with bacteriostatic antibiotics, as their bactericidal effect may decrease.

You can not combine Vilprafen with, as the effectiveness of both drugs decreases.

During pregnancy and lactation

Vilprafen 500 mg and Vilprafen Solutab during pregnancy and lactation may be prescribed after the doctor carefully evaluates the risks and benefits of such treatment. The doctor weighs what consequences are possible after using this drug, and only then prescribes a course of treatment. During pregnancy, Vilprafen can be used to treat chlamydia. However, if during the course of such treatment, side effects during pregnancy are noted, which are indicated by the instruction, it is necessary to stop treatment. Assessing the intake of Vilprafen during pregnancy, expectant mothers leave different reviews: from positive to those where we are talking about the appearance of side effects.