Curantyl or dipyridamole during pregnancy which is better. Vasodilating agent CJSC "pharmaceutical enterprise "Obolenskoye" dipyridamole Drug Curantil: composition and form of release, pharmacological properties

The drug "Kurantil" has been used in medicine for a long time. He managed to establish himself as one of the best medicines designed to normalize blood circulation. In recent years, the drug has also been used in gynecology. During pregnancy, an additional circle of blood circulation appears in the woman's body, which connects the mother with the fetus. Unfortunately, insufficiency of the fetoplacental functional system is quite common, so many women in position are prescribed this drug. In its absence, pregnant women can purchase any analogue of "Kurantil", for example, medicines "Dipyridamole" or "Persantin". All of them have the same active substance and the same indications for use.

How does the drug "Kurantil" in the body?

This medication belongs to the group of myotropic vasodilators. The vasodilatory effect of the drug is directed to the arterioles that are located in the brain, so this medicine often used to improve cerebral circulation. However, the medication also dilates other vessels, including placental ones. The drug acts on immune system by activating interferons and has a vasodilating effect. Thanks to this medication, the body is easier to resist viral infections. The analogue of "Kurantil" - the drug "Dipyridamole" has the same effects.

Indications for the use of the drug

Since the drug has a vasodilating effect, it is prescribed for ischemic lesions of organs. First of all, it is indicated for patients who have suffered a stroke or heart attack. The drug can be used to prevent insufficient cerebral or coronary circulation. It is prescribed to patients with a predisposition to thrombosis of any localization, for example, with varicose veins.

Prevention of insufficiency of fetoplacental circulation is another indication for the use of the drug.

The drug should be taken by patients who have undergone heart valve replacement surgery. In this case, its use is necessary to avoid vascular thromboembolism. The drug is used in small doses (25 mg each) for the prevention of viral infections. The analogue of "Kurantila", the drug "Dipyridamole", is indicated for the same diseases as the main drug. In the absence of the first in the pharmacy, you can safely replace it with the second.

Medication "Kurantil": analogues and prices

Medicines "Kurantil", "Dipyridamole", "Persantin" have the same active ingredient, so there are no structural differences between the drugs. The difference lies in the form of release, price, prevalence. Another difference is the manufacturer. The drug "Kurantil" is available in the form of tablets with a dosage of 25 and 75 mg of the active substance.

The price of the drug ranges from 350 to 550 rubles per package (100 tablets). The analogue of "Kurantila" (drug "Dipyridamole") is available in the form of a suspension intended for oral administration or tablets. One vial contains 150 ml of the drug. The daily dose of the drug is 300 mg, which is approximately equal to 6 teaspoons. The medication must be taken 3 times a day one hour before meals. The cost of the drug is about 65 rubles.

Another analogue of the drug "Curantil" is the solution for injection "Persantin". This medication is administered intravenously, so it enters the bloodstream faster. The price of the drug is about 210 rubles. By prescription, you can purchase both the drug itself and any analogue of "Kurantil". During pregnancy, it is necessary to discuss with the doctor the daily dose of the medication for which the prescribed drug was replaced.

Contraindications to the use of the drug

It should be remembered that the drug "Kurantil" is potent medicinal substance Therefore, in some severe conditions of the body, its use is prohibited. Contraindications to the use of the drug include:

Hypersensitivity to the active ingredient or excipients.
Unstable angina or myocardial infarction.
Heart failure in the stage of decompensation.
Low or high blood pressure (up to critical values).
Exacerbation of gastric ulcer or duodenal ulcer.
Children's age (up to 12 years).
Aortic stenosis.
Chronic renal and

There are contraindications. Please consult your doctor before taking.

Commercial names abroad (abroad) - Atrombin, Cardiwell, Persantine, Procardin, Thrombonil.

Currently, analogues (generics) of the drug are NOT FOR SALE in Moscow pharmacies!

Other drugs for the prevention and treatment of thrombosis.

You can ask a question or leave a review about the medicine (please do not forget to indicate the name of the drug in the text of the message).

Curantyl and Curantyl N DO NOT DIFFER in composition and method of application!

Preparations containing only Dipyridamole (Dipyridamole, ATC code (ATC) B01AC07)
Name	Release form	Packing, pcs	Producing country	Price in Moscow, r	Offers in Moscow
Curantyl (Curantyl)	dragee 25mg	100	Germany, Berlin Chemie	386- (medium 529↗) -804	221↘
Curantyl N25 (Curantyl N25)	tablets 25mg	120	Germany, Berlin Chemie	386- (medium 558↗) -854	231↘
Curantyl N75 (Curantyl N75)	tablets 75mg	40	Germany, Berlin Chemie	438- (medium 587↗) -943	578↘
Combined preparations containing dipyridamole
Aggrenox (Aggrenox)	Capsules (dipyridamole 200mg + acetylsalicylic acid 25mg)	30	Germany, Boehringer Ingelheim	785- (average 924↗) -1196	147↘

Curantyl (Dipyridamole) - official instructions for use. Prescription drug, information intended for healthcare professionals only!

Clinico-pharmacological group:

Antiaggregant. Immunomodulator

pharmachologic effect

Myotropic vasodilator. It has an inhibitory effect on platelet aggregation, improves microcirculation.

Dipyridamole dilates arterioles in the coronary circulation system, when taken in high doses - and in other parts of the circulatory system. However, unlike organic nitrates and calcium antagonists, expansion of larger coronary vessels does not occur.

The vasodilating effect of dipyridamole is due to two different mechanisms of inhibition: inhibition of adenosine uptake and inhibition of phosphodiesterase.

In vivo, adenosine is found at a concentration of approximately 0.15-0.20 µmol. This level is maintained due to the dynamic balance between ejection and recapture. Dipyridamole inhibits the uptake of adenosine by endothelial cells, erythrocytes and platelets. After the introduction of dipyridamole, an increase in the concentration of adenosine in the blood and an increase in vasodilation caused by adenosine are detected. At higher doses, inhibition of platelet aggregation caused by adenosine occurs, and the tendency to thrombosis decreases.

The breakdown of cAMP and cGMP, which inhibit platelet aggregation, occurs in platelets under the action of the corresponding phosphodiesterases. At high concentrations, dipyridamole inhibits both phosphodiesterases, at therapeutic concentrations in the blood, only cGMP-phosphodiesterase. As a result of stimulation of the corresponding cyclases, the power of cAMP synthesis increases.

As a pyrimidine derivative, dipyridamole is an interferon inducer and has a modulating effect on the functional activity of the interferon system, increases the reduced production of interferon alpha and gamma by blood leukocytes in vitro. The drug increases nonspecific resistance to viral infections.

Pharmacokinetics

Suction and distribution

After a single oral dose of 150 mg, Cmax of dipyridamole in plasma averages 2.66 μg / l and is reached within 1 hour after ingestion.

Dipyridamole is almost completely bound to plasma proteins. Dipyridamole accumulates in the heart and in red blood cells.

Metabolism and excretion

Dipyridamole is metabolized in the liver by binding to glucuronic acid. T1 / 2 is 20-30 minutes. It is excreted in the bile as a monoglucuronide.

Indications for use of the drug KURANTIL®

treatment and prevention of disorders cerebral circulation by ischemic type;
encephalopathy;
primary and secondary prevention of coronary artery disease, especially with intolerance to acetylsalicylic acid;
prevention of arterial and venous thromboses and treatment of their complications;
prevention of thromboembolism after heart valve replacement surgery;
prevention of placental insufficiency in complicated pregnancy;
microcirculation disorders of any type (as part of complex therapy);
prevention and treatment of influenza, SARS (as an interferon inducer and immunomodulator) - for taking the drug at a dose of 25 mg.

Dosing regimen

The dose of the drug is selected depending on the severity of the disease and the individual response of the patient.

For the prevention and treatment of disorders of cerebral circulation, as well as for prevention, 75 mg is prescribed 3-6 times a day. The maximum daily dose is 450 mg.

To reduce platelet aggregation, Curantyl is prescribed at a dose of 75-225 mg per day in divided doses. In severe cases, the dose may be increased to 600 mg per day.

For the prevention of influenza and SARS, especially during epidemics, Curantil N25 and Curantil 25 are prescribed 50 mg (2 tablets or 2 tablets) per day in 1 dose. The drug is taken once a week for 4-5 weeks.

To prevent recurrence of acute respiratory viral infections in patients with frequent respiratory viral infections, Curantil N25 and Curantil 25 are prescribed 100 mg per day (2 tablets or 2 pills with an interval between doses of 2 hours). The drug is taken once a week for 8-10 weeks.

Tablets should be taken on an empty stomach, without breaking or biting, with a small amount of liquid. The duration of the course of treatment is determined by the doctor.

Side effect

From the side of the heart vascular system: palpitations, tachycardia (especially with the simultaneous use of other vasodilators), bradycardia, flushing of the face, flushing of the skin of the face, coronary steal syndrome (when using the drug at a dose of more than 225 mg per day), lowering blood pressure.

From the side digestive system: nausea, vomiting, diarrhea, pain in the epigastric region. Usually these side effects disappear with longer use of the drug.

From the blood coagulation system: thrombocytopenia, changes in the functional properties of platelets, bleeding; in isolated cases - increased bleeding during or after surgery.

From the side of the central nervous system: dizziness, noise in the head, headache.

Allergic reactions: skin rash, urticaria.

Other: weakness, sensation of ear congestion, arthritis, myalgia, rhinitis.

When using the drug in therapeutic doses, side effects are usually mild and transient.

Contraindications to the use of the drug KURANTIL®

acute myocardial infarction;
unstable angina;
widespread stenosing atherosclerosis coronary arteries;
subaortic stenosis of the aorta;
heart failure in the stage of decompensation;
arterial hypotension;
collapse;
severe arterial hypertension;
severe cardiac arrhythmias;
chronic obstructive pulmonary disease;
chronic renal failure;
liver failure;
hemorrhagic diathesis;
diseases with an increased risk of bleeding (including peptic ulcer of the stomach and duodenum);
hypersensitivity to the components of the drug.

The use of the drug KURANTIL® during pregnancy and lactation

It is possible to use the drug during pregnancy according to indications.

The use of the drug during lactation is possible only if the expected benefit of treatment outweighs the possible risk.

Application for violations of liver function

Contraindicated in liver failure

Application for violations of kidney function

Contraindicated in chronic renal failure

special instructions

With the simultaneous use of tea or coffee (contain xanthine derivatives), the vasodilating effect of Curantyl may decrease.

Pediatric use

Influence on the ability to drive vehicles and control mechanisms

Caution should be exercised when driving vehicles and operating mechanisms, since as a result of a drop in blood pressure while taking Curantyl, the ability to concentrate and speed of psychomotor reactions may worsen.

Overdose

Symptoms: decreased blood pressure, angina pectoris, tachycardia, flushing, weakness and dizziness.

Treatment: artificial vomiting, gastric lavage, appointment activated carbon. The vasoconstrictor effect of the drug can be stopped by slow (50-100 mg / min) intravenous administration of aminophylline. In case of persisting symptoms of angina pectoris, the appointment of sublingual nitroglycerin.

drug interaction

With the simultaneous use of Curantyl with anticoagulants or acetylsalicylic acid the antithrombotic effect of the latter increases and, accordingly, the risk of developing hemorrhagic complications.

With the simultaneous use of Curantil enhances the effect of antihypertensive drugs.

When used together, Curantil may weaken the anticholinergic effects of cholinesterase inhibitors.

With simultaneous use, xanthine derivatives weaken the vasodilating effect of Curantyl.

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Terms and conditions of storage

List B. The drug should be stored in a place protected from light, out of the reach of children, at a temperature not exceeding 30°C. Shelf life Curantyl N 25 and Curantyl N 75 - 3 years, Curantyl 25 - 5 years.

Curantil belongs to the category of drugs that provide antianginal, angioprotective and antiaggregatory effects on the body. If in the first case we are talking about preventing new attacks of angina, manifested acute pain behind the sternum, the antiplatelet effect is due to the protection of the circulatory system from the accumulation and adhesion of blood clots.

Angioprotective effects are characterized by additional protection of the vascular system, restoration of its elasticity and optimal lumen. Having dealt with the main purposes of the drug, it is possible to adequately determine the analogues of Curantyl. Thus, it is always possible to change the prescribed drug for any reason.

Among the most suitable expensive and cheap analogues, it is important to always focus on their description, the principle of pharmacological action, indications for use and, of course, contraindications.

Dipyridamole

This medicine is distinguished by the crystalline structure of a yellow powder, which is rather difficult to dissolve in water. The original purpose of using this substitute for Curantyl is to have a coronary dilating and antianginal effect. Thanks to him, there is an expansion of the heart vessels and the prevention of possible new attacks of angina pectoris, accompanied by acute pain behind the sternum. The drug helps to increase the volumetric blood flow rate in the coronary (cardiac) vessels, which is essential for the full supply of oxygen to the heart, as well as increase the stability of the myocardium in conditions of its shortage.

the risk of platelet adhesion and the manifestation of blood clots in the vessels (especially in the postoperative period);
myocardial infarction;
circulatory disorders in the brain.

In medical practice, there is evidence that taking Dipridamole also improves the general condition of the blood and the performance of the kidneys in patients with glomerulonephritis.

It is recommended to use the drug at a dose of 25 mg three times a day if there is a risk of increased blood clotting. With manifestations of angina pectoris, the doctor may prescribe 25–50 mg of the substance in 3 divided doses throughout the day. In such cases, it is necessary to use the drug on an empty stomach and one hour before a meal. The course of treatment is selected individually and can last from several weeks to months.

The drug is not recommended to be administered intravenously due to the risk of uneven distribution in the bloodstream of the coronary vessels. In this case, the drug is not allowed to be taken by patients with sclerosing atherosclerosis of the coronary arteries, accompanied by the closure of the lumen in the vessels.

Parsedil

The drug is effective tool against the manifestation of thrombosis and thromboembolic complications, suitable for both the prevention of diseases and their therapy. The drug is also recommended in the diagnosis of chronic heart failure. The process of absorption of the tablet occurs quite quickly, the maximum efficiency is observed after an hour. The metabolism of the drug takes place in the liver, and is excreted from the body along with the bile.

The main effect is based on the expansion of the coronary arteries and the normalization of venous outflow, reducing the risk of thrombosis in the postoperative period. Such a drug requires extreme caution when used during pregnancy, especially in the second and third trimesters.

Of the side effects, it is worth highlighting the increasing headache, manifestation of tachycardia and dyspeptic disorders. It is recommended to use the drug orally and on an empty stomach, one hour before meals. Subject to simultaneous administration with acetylsalicylic acid, the medicinal substance must be used three times a day, 75 mg each.

An overdose of the drug may indicate a temporary sharp increase blood pressure.

Pencelin

As in the previous two examples, the drug has an antiplatelet (antithrombotic) effect on the body. Often it is prescribed to prevent the manifestation of arterial and venous thrombi after operations with prosthetic heart valves, as well as to prevent myocardial hypertrophy.

Of the possible side effects, it is worth noting palpitations, tachycardia, redness of the face and a feeling of flushing, a significant decrease in blood pressure. In addition to headaches, dizziness and tinnitus are allowed according to the instructions. Not allowed for use by patients under 18 years of age, as well as during pregnancy and lactation. When using medication tablets, it is recommended to avoid natural coffee and tea, which weaken the effect of the medication itself. In order to reduce dyspeptic symptoms, the drug is recommended to be taken with milk.

Persanthin

The action of this substitute drug is relevant in the diagnosis of cerebral infarction, cerebrovascular and encephalopathic diseases, peripheral vascular disease, as well as embolism and thrombosis. The drug has a vasodilating (vasodilating) and antiaggregatory effect on the body. With its help, prevention and direct treatment of disorders in cerebral circulation of the ischemic type, dyscirculatory encephalopathy, as well as venous and arterial thrombosis and their possible complications are carried out.

The maximum effectiveness of the drug can be observed in an hour or an hour and a half after administration. Metabolism of the substance occurs in the liver and is excreted from the body along with bile. Of the contraindications, it is worth highlighting stenosing atherosclerosis of the coronary vessels, an acute form of myocardial infarction, subaortic stenosis, as well as decompensated heart failure.

Side effects of the drug can manifest as diarrhea, nausea, vomiting, as well as tachycardia, dizziness and recurring headache.

You can replace Curantil with drugs, both foreign and domestic (Russian) production, which often differ in the composition and extent of the effect on the body, as well as in price. In any case, the possibility of choosing a cheaper or more affordable treatment option should be discussed with the doctor, since the effectiveness of the drug and its correct dosage determined individually in each individual case.

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

Drug Curantil

Curantyl known in the pharmaceutical market for a long time. It is used as an antianginal (anti-angina drug), antiplatelet (antithrombotic) and angioprotective (protecting blood vessels) agent.

Curantil has a vasodilating effect mainly on the small vessels of the heart, but in large doses it reduces the resistance in the arterioles of the whole body and leads to a decrease in blood pressure. Due to the expansion of the diameter of the vessels, blood circulation increases and oxygen flow to the cells improves, therefore, the damaging effect of hypoxia or ischemia, which often occurs with heart diseases, is leveled. Curantil promotes the formation of collaterals (bypass routes) in ischemic areas, improves the functioning of the heart muscle, and lowers blood pressure.

Curantil improves microcirculation in the vessels of the brain, retina, kidneys. During pregnancy, it slows down degenerative processes in the placenta, eliminates hypoxia of fetal tissues and restores placental circulation.

In addition, the drug prevents the adhesion of platelets and the formation of blood clots, especially with the combined use of Curantyl and acetylsalicylic acid. With an increase in a single dose of the drug, a shortening of the life of platelets and suppression of the tendency to thrombosis is observed. This effect is used in the treatment of patients with deep vein thrombosis. The combined use of Curantyl and acetylsalicylic acid is often prescribed in the complex treatment of atherosclerosis, as well as to reduce the risk of recurrent stroke in patients with ischemic stroke.

The main active ingredient of Curantyl - dipyridamole, which contributes to an increase in the production of interferon - a protein with a pronounced antiviral action. In this regard, Curantyl can be used as a drug that increases the body's resistance to viral infections.

And the last scope of Curantyl is stress echocardiography and dipyridamole-thallium-201 perfusion scintigraphy in the diagnosis coronary disease hearts in patients with unchanged coronary vessels. In this case, the drug is used as a diagnostic tool to determine the state of the heart muscle, the safety of the valvular apparatus and its contractile activity.

Release form

Curantil is available in tablets, dragees and solutions for intravenous administration.

Tablets yellow or greenish-yellow, coated. Each tablet contains 25, 50, 75 or 100 mg of the active substance dipyridamole. Depending on this, the drug is called Curantyl 25, Curantyl 50, Curantyl 75 or Curantyl 100.

Dragee contain 25 or 75 mg of dipyridamole. Usually dragees are packaged in glass jars 100 pcs.

In ampoules a 0.5% solution of dipyridamole is produced. 2 ml of each ampoule contains 0.01 g of the active substance.

Instructions for use Curantyl

Indications for use

Curantyl is prescribed for adults and children over 12 years of age who have vascular disorders in the brain, retina, heart, kidneys, deep vessels of the extremities. In obstetric practice, it is used for circulatory disorders in the placenta and deterioration in the nutritional conditions of the fetus.

The main indications for the appointment of Curantyl are:

Treatment of ischemic heart disease, subacute infarction myocardium or post-infarction condition, stable angina, especially with intolerance to acetylsalicylic acid. With these diseases, Curantyl can also be prescribed for prophylactic purposes.
Prevention of thromboembolism and thrombosis of arteries and veins in the postoperative period when replacing heart valves.
Widespread atherosclerosis of the heart vessels.
Heart failure in the stage of compensation.
Hypertension II degree and above.
Deterioration of placental circulation, fetal hypoxia, placental insufficiency.
Chronic cerebrovascular insufficiency, cerebral infarction, dyscirculatory encephalopathy.
As part of complex treatment with various microcirculatory disorders.
As an immunomodulatory drug (to increase immunity) during periods of influenza epidemics, SARS.

Contraindications

Any acute conditions caused by impaired microcirculation, unstable or decompensated diseases, as well as increased bleeding are contraindications for the appointment of Curantyl.

Children under 12 years of age are not prescribed the drug, because. there is insufficient data on its harmlessness to the child's body.

The drug is not prescribed for the following diseases or states:

Acute cerebral or myocardial infarction;
Acute or unstable course of angina pectoris;
Heart, kidney, liver failure in the stage of decompensation;
Arterial hypotension, collapse, fainting;
Vegetovascular dystonia of the hypotonic type;
Heart rhythm disturbances - ventricular arrhythmias, atrial fibrillation, etc.;
Obstructive diseases of the bronchopulmonary system;
Subvalvular (subaortic) aortic stenosis;
Common coronary sclerosis;
Tendency to spontaneous bleeding, the presence of peptic ulcer (due to possible development bleeding), hemorrhagic diathesis;
Intolerance to any of the components of the drug.

Side effects

Side effects while taking Curantyl occur quite rarely. Among them, the main place is occupied by dyspeptic phenomena - nausea, occasionally vomiting and diarrhea. There may be complaints of headache or muscle pain, weakness and dizziness. People with a tendency to arterial hypotension are likely to develop fainting and / or increase the heart rate to 90 or more times per minute.

In some cases, the phenomenon of cardiac "steal" occurs - a retrograde movement of blood through the collaterals, bypassing the narrowed coronary vessels. A withdrawal syndrome may also develop with the development of unstable angina or myocardial infarction. This phenomenon usually occurs when long-term treatment Curantyl.

Extremely rare adverse reactions are urticaria and bronchospasm, as well as changes in the blood, in particular a decrease in the number of platelets (thrombocytopenia).

Unlike acetylsalicylic acid (aspirin), Curantil does not cause ulceration in the gastrointestinal tract.

Treatment with Curantil

The doctor selects the dosage and duration of taking Curantyl individually, based on the form of the disease, the severity of its course and the patient's sensitivity to the drug. If necessary, the drug can be taken for a long time, in some cases - up to 10 weeks or more.

Self-administration of the drug is not allowed, due to the fact that its incorrect or unreasonable intake may worsen the patient's condition. Curantyl is a prescription drug.

How to take Curantyl?
The drug is taken before meals or 1.5-2 hours after a meal. The tablet or dragee should not be chewed, they must be swallowed with a sufficient amount of non-carbonated water.

Dosage of Curantyl
The maximum daily dose of the drug is 600 mg, it is prescribed only during the treatment of severe disorders. With the simultaneous administration of Curantyl with anticoagulants or acetylsalicylic acid, the dose of Curantyl is halved.

Depending on the nature of the disease, Curantyl can be prescribed in the following dosages:
1. In coronary heart disease, the initial daily dose of the drug is 225 mg. The dose is divided into 3 doses.
2. In case of cerebral circulation disorders, Curantyl is prescribed 75 mg 3 to 6 times a day.
3. As an antiplatelet agent, Curantyl is prescribed 3-6 tablets per day, dividing the dose into several doses. If necessary, the daily dose can be increased to 8-9 tablets.
4. During an epidemic of influenza and SARS, Curantyl is taken 1-2 tablets once a week for 1.5 months. To increase immunity in frequently ill people, the drug is prescribed at 100 mg per week (the dose is taken in 2 doses, the interval between doses is 2 hours) for up to 8-10 weeks.

Curantyl during pregnancy

Curantyl is allowed to be taken during pregnancy, it does not have a negative effect on the fetus. However, in the 2nd and 3rd trimesters, it should be taken with extreme caution and if there are clear indications for this.

Most often, Curantyl is prescribed for pregnant women with placental insufficiency, late toxicosis, concomitant cardiovascular and renal pathology, premature aging of the placenta, post-term pregnancy.

Curantyl can also be used to increase nonspecific immunity in pregnant women during periods dangerous for viral diseases or with frequent exacerbations of an existing chronic viral infection(for example, genital herpes).

Interaction of Curantyl with other drugs

During treatment with Curantil, it is undesirable to drink drinks containing caffeine (coffee, cocoa, tea, mate, Coca-Cola, Pepsi-Cola), as well as take the drug diuretin. These substances can significantly reduce or neutralize the completely positive effects of Curantyl.

With simultaneous treatment with Curantil and indirect anticoagulants (drugs that reduce blood clotting), as well as acetylsalicylic acid, the dose of Curantil should be reduced, because. its activity rises sharply and there is a risk of spontaneous bleeding.

Curantil may enhance the effect of drugs prescribed to lower blood pressure. And, on the contrary, when using Curantyl and drugs for the treatment of Alzheimer's disease, dementia, myasthenia gravis, a decrease in the activity of the latter is observed.

The simultaneous use of Curantyl and antibiotics of the cephalosporin series (Cefamandol, Cefoperazone, Cefotetan) leads to an increase in the antiplatelet properties of Curantyl.

Antacids used for increased acid-forming function of the stomach reduce the absorption of Curantyl, which causes a decrease in the therapeutic effect.

It is not allowed to mix the Curantyl solution for intravenous injection with other injectable drugs due to the fact that an insoluble precipitate may form. Do not mix Curantyl's solution with Actovegin, tk. the latter can cause anaphylaxis. However, the tablet forms of Curantil and Actovegin are often prescribed in the complex treatment of microcirculatory disorders of various origins.

Analogues of Curantyl

Curantyl has a lot of analogues. Depending on the country and the manufacturer, the drug is produced under the following trade names:

Dipyridamole;
Parsedyl;
Persanthin;
Trombone;
Sanomil-Sanovel;
Anginal (Anginal);
Antistenocardin (Antistenocardin);
Trancocard (Trancocard);
Aprikor (Apricor);
Cardioflux (Cardioflux);
Coribon (Coribon);
Trombonil (Trombonil);
Viscor (Viscor);
Vadinar.

This article is about the rules for taking Curantyl during pregnancy - for what indications it should be taken, what it affects, how it should be taken. And also its composition, contraindications, side effects and analogues of this remedy are described here. During pregnancy, many women become especially attentive to their health, often during this period they have to drink various vitamin complexes, as well as folic and ascorbic acid. But there are cases when future mothers are prescribed Curantyl. But this tool is related to medicines which, as you know, it is not advisable to take during this period. Although the reviews of many young mothers about this medicine are only positive, you still need to be examined before using it. It should be prescribed by a specialist and only according to indications. But in order to be aware and warn yourself in advance, you need to familiarize yourself in detail with all the properties of this tool.

Curantil is a drug that has an antiaggregatory effect. Getting into the cells of the body, it reduces the reverse transport of adenosine and ensures the accumulation of this substance in the intercellular space.

Trade name - Curantil 25 or Curantil 75;

International non-proprietary name (INN) - Dipyridamole.

Release form - tablets round shape covered with a yellow sheath. Produced in blisters in a carton box of 10, 20.30 tablets, the package contains an annotation with a full description of the drug. Also available in glass bottles of 100 pieces.

Composition

The composition of the medicine includes the following components:

The active ingredient is dipyridamole.
Excipients - corn starch, lactose monohydrate, gelatin, magnesium stearate, talc.
The substances that make up the shell are sucrose, calcium carbonate, magnesium carbonate, talc, macrogol 6000, dextrose syrup, titanium dioxide, polyvidone K25, carnauba wax, yellow quinoline type dye (E104).

Why is chimes prescribed during pregnancy

Curantyl belongs to the group of antiaggregants. Means of this group prevent platelets from sticking together and increase their lifespan. In addition, the drug thins the blood, accelerates blood circulation and has a strengthening effect on blood vessels. Especially often it is prescribed during pregnancy, there can be many reasons for this. Often during pregnancy there is a violation of blood microcirculation - these are the first symptoms of preeclampsia. This condition usually occurs when the child is overextended, and if the overbearing increases by one week, then preeclampsia increases by almost 10%. Therefore, in order to avoid unpleasant problems, it is necessary to take Curantyl during pregnancy to improve blood microcirculation.

The second main reason why Curantyl is prescribed to pregnant women is the prevention of placental insufficiency. During this pathology, the placenta stops its functions, namely, it stops supplying the embryo with oxygen and nutrition.

Curantyl has a positive effect on blood circulation, eliminates the lack of oxygen in the tissues of the fetus. In addition, it prevents a delay in the intrauterine development of the child, and also prevents the development of negative pathologies in the placenta, such as detachment.

In addition to these reasons, Curantyl is prescribed to pregnant women for the following indications:

in preventive purposes or treatment of pathologies of blood circulation in the placenta;
with fetal hypoxia;
with an increase in the number of platelets, this indication is usually diagnosed by blood tests;
to protect against seasonal viral colds - SARS, acute respiratory infections and influenza;
if there is high blood clotting;
low blood circulation in the capillaries;
symptoms of preeclampsia, namely edema, impaired blood flow and disorders of the vascular system;
with a lack of vitamin B6, which causes convulsions, dizziness, fainting;
at arterial hypertension – high blood pressure;
to prevent thrombosis during varicose veins.

It is worth remembering that with a lack of vitamin B6 it is not always worth taking Curantil. To compensate for the lack of this vitamin will help vitamin complex Magnesium B6, which, in addition to this vitamin, contains other nutrients necessary for the full development of the child.

The effect of chimes on the body during pregnancy

Before you understand whether Curantyl is harmful or useful during pregnancy, it is worth considering in detail how it affects the body during administration:

Do not worry about the baby, the drug does not have a harmful effect on him. It affects only the blood vessels of the placenta, which is a barrier that does not allow medicine and infections to pass to the baby;
During the reception, blood thinning occurs, which in turn prevents the formation of blood clots;
Has a positive effect on blood circulation;
Prevents the appearance varicose veins veins and hemorrhoids;
During arterial hypertension brings pressure back to normal;
Improves kidney function;
It has a strengthening effect on the walls of blood vessels;
It also relieves cramps;
Relieves swelling of the hands and feet.

Reception of Curantyl in the early stages

Usually, Curantyl is prescribed once during pregnancy, but sometimes there are cases when it lasts throughout the entire period of pregnancy. It is worth remembering that nausea during pregnancy and unpleasant signs of toxicosis are not all that may bother you in the first trimester.

Usually on early dates Curantyl is prescribed to normalize the blood flow of the placenta. With this violation, the child is deprived of all the necessary nutrients, and oxygen is not supplied to him, which ultimately causes hypoxia. Taking Curantyl normalizes blood circulation in the placenta and eliminates serious consequences. But, nevertheless, many doctors believe that taking the medicine in the early stages is undesirable, because it can cause bleeding.

Curantyl: instructions for use during pregnancy

Many people wonder - how to drink Curantyl? Only a specialist can accurately determine the exact dosage and period of administration. In no case should you start taking the drug on your own or make adjustments to the doctor's prescription - all this can have harmful effect on a child.

Rules for taking medication during pregnancy and dosage:

The maximum level of Curantyl per day can be 75-225 mg. The dose should be divided into 3-5 times.
For prevention, the dose of the drug should be reduced to 25-50 mg per day.
With obvious problems of blood clotting, the dosage of the drug should be no more than 600 mg per day.
Tablets should be taken before meals, they should be washed down with plain water.
The course of treatment is different, sometimes it can last until the very last days of pregnancy.

It is also worth paying attention to the instructions for use, depending on the dosages of the drugs:

Curantyl 25 during pregnancy is prescribed quite often. Tablets 25 mg should also be taken before meals and washed down with water. Dosage per day - 1 tablet of 25 mg in the morning, afternoon and evening.
Curantyl 75 differs from 25 in that it has a high content of the active substance - dipyridamole. Tablets of 75 mg are taken during heart failure, problems with the blood circulation of the brain, as well as for the prevention of viral diseases of acute respiratory viral infections, acute respiratory infections, influenza and to reduce platelet aggregation.

Actovegin and chimes during pregnancy

In many reviews of future mothers, you can find questions about whether it is possible to take Actovegin and Curantil during pregnancy in complex treatment. It is impossible to answer this question unequivocally, since the attending physician should decide on the basis of their testimony. But it is worth noting that among the many drugs for the complex treatment of pathologies during pregnancy, Actovegin and Curantil are the most compatible. This is all due to their effect on various vascular pathologies that occur during pregnancy. Kurantil Actovegin is used for complex treatment during pregnancy with the following indications:

Symptoms of preeclampsia - a violation of blood microcirculation, increased clotting blood, disorders of the vascular system.
Chronic viral diseases.
With severe swelling.
With high blood pressure.
During the threat of miscarriage.

Dipyridamole or chimes - which is better?

The drugs Curantyl and Dipyridamole have the same pharmacological properties, the difference is in price, form of release and prevalence. After all, Dipyridamole is much cheaper compared to Curantyl, its cost is 65 rubles. And the price of Curantyl in many pharmacies ranges from 350 to 550 rubles per 100 tablets. Another difference in the form of release - Curantyl is available in the form of tablets of 25 mg and 75 mg, and Dipyridamole in the form of a suspension for oral administration and in the form of tablets. Usually one bottle of Dipyridamole contains 150 ml and it should be taken at a dosage of 300 mg per day, about 3 teaspoons.

Contraindications

A careful reading of the annotation can reveal a sufficient number of contraindications:

it is not recommended to take the drug with an insufficient number of platelets in the blood and with poor blood clotting;
not allowed to be taken by pregnant women who have a stomach ulcer and 12 duodenal ulcer;
it is forbidden to drink Curantyl with greatly increased or decreased blood pressure;
contraindicated in diseases of the liver, heart, kidneys and other internal organs;
it is not advisable to take the medicine if there are various allergic reactions and hypersensitivity to the constituent components of the drug.

Side effects

Like all medicines, Curantil has side effects which may occur in the following conditions:

frequent heartbeat, heart rhythm disturbances, lowering blood pressure, red rashes on the skin of the face, a feeling of heat;
the occurrence of dyspeptic disorders, pain in the stomach, the appearance of nausea;
hematomas on the surface of the body and increased bleeding may occur;
migraine, tinnitus sensation;
sometimes there are various allergic reactions, skin rashes;
the appearance of a feeling of weakness, pain in the muscles and joints.

Curantyl and alcohol: compatibility

When drinking alcohol while taking Curantyl, unpleasant and sometimes dangerous health consequences may occur. Alcohol reduces the effect of any drug, including Curantil. As a result, all this can lead to serious problems that can be life threatening. It should be borne in mind that the drug is prescribed only in rather difficult situations.

The description of the annotation of the drug indicates that it is intended to eliminate circulatory disorders of any origin. During the use of alcoholic beverages, a person can cause serious harm to health, since alcohol leads to impaired blood flow throughout the body.

Analogues of Russian-made chimes

In addition to Curantyl, in pharmacies you can find other cheap analogues of Russian production:

Dipyridamole
Apo-dipyridamole
Dipyridamole ferein
Vero dipyridamole
Persanthin
Persadil
Parsedil
Persanthin
Trombone.

Pregnancy is a difficult period, which manifests itself in every woman in different ways. Often, women can have serious problems - vascular disorders, increased blood clotting, high blood pressure, viral diseases, various symptoms of preeclampsia. Sometimes in these cases, you need to take Curantyl. But it is worth remembering that this is a drug, and in order to avoid serious consequences, it should be prescribed by the attending physician and only according to indications after a complete examination.