Pentalgin n instructions for use. Pentalgin H - analgesic for pain syndrome of various origins

Prohibited while breastfeeding

Forbidden to children

Has restrictions for the elderly

Has limitations for liver problems

Has limitations for kidney problems

Most of the pathological processes that occur in the body are accompanied by the appearance of a pronounced pain syndrome. With the ineffectiveness of monocomponent drugs, it becomes necessary to use stronger combined agents containing an analgesic and substances that enhance and prolong its action. Popular in our country is Pentalgin N.

General information about the drug

The choice of an anesthetic drug is influenced by factors such as the mechanism of pain (somatogenic, neurogenic or psychogenic), the individual characteristics of the patient's body, the presence of concomitant diseases. Combined analgesics have a number of pronounced clinical effects: analgesic, anti-inflammatory, antipyretic, sedative, antispasmodic.

Drug group, INN, scope

According to the International Anatomical Therapeutic Classification of Medicines of the latest revision, Pentalgin N belongs to the group "N02 Analgesics", a subgroup - a combination of metamizole sodium with psycholeptics. Pharmacological group - non-steroidal anti-inflammatory drugs, combinations of propionic acid derivatives.

According to international recommendations World Health Organization for stepwise pain therapy, Pentalgin N is used at the 2nd stage with the ineffectiveness of non-opioid monocomponent drugs - salicylates, paracetamol and other NSAIDs.

Forms, composition and prices for the drug, average in Russia

Pentalgin N is produced by the Russian company Pharmstandard in tablet form. On round tablets of white color (a slightly beige shade is allowed) a dividing strip is applied on one side. Carton packs contain one or two blisters with 10 tablets. Since June 2012, all codeine-containing drugs are dispensed only with a prescription from a doctor.

The active ingredients that have a therapeutic effect are:

1. () - 0.3 g.
2. Caffeine-sodium benzoate - 50 mg.
3. Codeine phosphate - 8 mg.
4. Naproxen - 0.1.
5. Phenobarbital - 10 mg.

To shape and protect the components from premature splitting when exposed to the aggressive environment of the gastrointestinal tract, Pentalgin N includes potato starch, sodium citrate, lactose monohydrate, microcellulose, magnesium stearate, povidone-iodine.

Unlike tablets with codeine, you can buy ordinary Pentalgin without a prescription. The composition of the Pentalgin preparation includes paracetamol (an analgesic), naproxen (NSAIDs), drotaverine (an antispasmodic), pheniramine ( antihistamine), caffeine (psychostimulant).

Pharmacodynamics and pharmacokinetics

The main active ingredient is metamizole sodium, commonly known as analgin. The mechanism of action is associated with blocking the activity of the cyclooxygenase enzyme, which reduces the concentration of inflammatory mediators - prostaglandins, kinins. It also has a regulatory effect on lipid peroxidation reactions, disrupts the conduction of pain impulses along nerve fibers, and increases heat transfer.

Naproxen is a non-steroidal anti-inflammatory drug with antipyretic, analgesic, and antiplatelet properties. Non-selectively reduces the action of COX type 1 and 2, which leads to inhibition of the synthesis of arachidonic acid and other prostaglandin precursor products. Also, naproxen reduces the aggregation properties of platelets and reduces the migration of leukocytes.

The sedative and weak hypnotic effect of Pentalgin N is due to the presence of phenobarbital (a derivative of barbituric acid) in the composition. It reduces the excitability of the central nervous system due to competitive binding to the barbituric receptors of neurons, and also increases the concentration of GABA (inhibitory neurotransmitter).

Caffeine not only enhances the analgesic and anti-inflammatory effects of naproxen and analgin, but also has a general tonic and psychostimulant effect. This is due to the blocking of central and peripheral adenosine receptors, inhibition of phosphodiesterase activity, and stabilization of transmission in dopaminergic synapses.

Codeine is an opioid receptor agonist. Enhances the analgesic effect of NSAIDs by stimulating the antinociceptive system. Able to influence the perception of pain by a person.

Indications and contraindications

The drug has a pronounced effect on somatic, neurogenic pain of varying intensity. Most often, Pentalgin N is prescribed in the presence of the following symptoms and diseases:

Pentalgin N is used for colds, acute respiratory diseases to eliminate cough and high fever.

It is forbidden to use the drug for people suffering from arterial hypertension, coronary heart disease, heart failure, as well as those who have had myocardial infarction and stroke.

Contraindications to the appointment of Pentalgin N are also:

• individual intolerance to one of the components;
• gastritis, stomach ulcer and/or duodenum;
• bronchial asthma;
• traumatic brain injury;
• increased intracranial and intraocular pressure;
• liver and kidney failure;
• cardiac arrhythmias.

Use during pregnancy is contraindicated due to possible teratogenic effects. If it is necessary to take the drug, a nursing woman should stop breastfeeding for 48 hours after taking the tablets. Prescribing the drug to children under 14 years of age is strictly prohibited.

Instructions for use

Before prescribing Pentalgin N, you should carefully read the instructions for use. In addition to the correct calculation of the dosage, it is important to familiarize yourself with the list of side effects that may occur during therapy in order to pay attention to them in a timely manner and contact a specialist.

Features of administration and dosage

Tablets are intended for oral intake. They can not be crushed, chewed and absorbed. Drink only clean water, as juices, tea, coffee can disrupt pharmacological properties drug and cause side effects.

Usually, this medicine is used to relieve acute pain once. However, if there is a need for longer therapy, the benefits and risks of taking these tablets should be evaluated.

The maximum course of treatment is 5 days. You can drink no more than 4 tablets per day, while the minimum time interval between doses is 4-5 hours.

Possible side effects and overdose

With intolerance to the drug, the development of adverse reactions is possible. They are accompanied by a violation of the general condition - excessive drowsiness, irritability, apathy. When taking Pentalgin, the following undesirable effects may develop:

• headache;
• tachycardia;
• skin itching, rash;
• indigestion (diarrhea, constipation, feeling of heaviness in the intestines);
• toxic hepatitis with an increase in liver tests;
• feeling of nausea, vomiting that does not bring relief;
• anemia and leukopenia.

When using large doses of the drug, an overdose may occur. Its main manifestations include:

• respiratory failure, bronchospasm;
• pain in the epigastric region;
• vomit;
• violation of the heart rhythm.

If these symptoms occur, it is necessary to immediately wash the stomach, drink a sufficient amount of liquid and take sorbents.

drug interaction

In complex therapy, it is important to consider the compatibility of the agent:

Analogues

Pharmstandard company ( The Russian Federation) produces several varieties of the drug:

A cheap analogue of Pentalgin N is Plivalgin, the manufacturer is Pliva Horvatska, the Croatian Republic. It has a pronounced antipyretic, antianginal and anti-inflammatory effect due to the combination of NSAIDs (propyphenazone), caffeine, phenobarbital and codeine in it. The cost of packing 10 tablets is an average of 240-250 rubles.

The combined analgesics-antipyretics with codeine, often used in our country, include Sedal-M. It is produced by the Bulgarian pharmaceutical company Sopharma. Contains in its composition two NSAIDs - analgin (150 mg) and paracetamol (300 mg). The action of these substances is enhanced by caffeine, codeine, phenobarbital. The average price in Moscow for package No. 10 is 287-290 rubles.

When pain occurs, it is not possible to lead a normal life. To cope with this, we resort to different medicines. One of these is Pentalgin N.

Due to the peculiarities of the composition, one should take it responsibly and preliminarily study useful information about the medicine.

This article describes detailed instructions for the use of Pentalgin N, as well as additional recommendations that will help avoid negative consequences from treatment.

The drug is available in the form of white tablets. Sometimes they can have a yellowish or creamy tint. They go on sale in a cardboard box, 1-2 cells with 10 tablets.

Composition of Pentalgin N and pharmacological action

Pentalgin N performs several functions at once: it helps to relieve pain, reduce inflammation, has antipyretic, analgesic and psychostimulant properties.

The composition contains 5 active ingredients: metamizole sodium (Metamizole sodium), naproxen (Naproxen), caffeine (Caffeine), phenobarbital (Phenobarbital) and codeine (Codeine).

The active composition of Pentalgin N is indicated in brackets. Latin.

The combined effect of the drug is achieved when exposed to each of the following substances:

• Due to metamizole and neproxen, an analgesic effect is achieved, inflammation is removed.
• Codeine acts as an opioid receptor stimulant. As a result, the analgesic system is activated, the emotional perception of pain by a person changes, he feels the ability to withstand it. The component also affects the cough center - it reduces excitability and, accordingly, relieves cough.
• Phenobarbital in combination with codeine enhance the analgesic effect of the above components.

When to take Pentalgin N

The drug is prescribed in such situations:

• There are prolonged pain sensations (usually weak or moderate) of a different nature, most often in cases of joint, muscle, toothache, neuralgia, with sciatica, migraines, heavy menstruation;
• If a person is in a state of fever, with a cold or other diseases that are accompanied severe pain and inflammatory processes.

How Pentalgin N affects pressure

Due to the presence of caffeine in the composition, when taken in doses, tablets can cause a slight increase in pressure. For this reason, they are contraindicated in people with severe hypertension.

Usually, if a person's pressure is normal or slightly low, the values ​​​​on the tonometer do not change.

A noticeable increase in pressure occurs when the drug is used above the specified norm or when long-term treatment. According to the norm, in order not to cause problems with the cardiac system, a healthy person should not take more than 4 tablets daily for no more than 5 days.

Who should not take Pentalgin N

The strong active substances that are included in the Pentalgin P preparation make it necessary to take it with extreme caution. Moreover, not everyone is allowed to take these pills.

The drug is completely contraindicated:

• In cases of complex diseases associated with the kidneys and liver;
• If you have leukopenia or anemia;
• With erosive and ulcerative lesions in the gastrointestinal tract in the acute stage;
• With bronchial asthma;
• People with heart problems, increased intracranial pressure, those who have had a myocardial infarction, are prone to arrhythmia and hypertension;
• Children under 7 years old;
• Being under the influence of alcohol;
• Due to the potent components in the composition, the drug is prohibited during pregnancy (if there was a need to drink pills during breastfeeding should consider stopping this method of feeding).

• Aged people;
• People with diseases of the stomach or duodenum in remission;
• Cases of arterial hypertension in mild or moderate form.

Side effects from the drug

In people taking Pentalgin N, in rare cases such undesirable phenomena are observed:

• Depending on personal intolerance to certain components, various allergic reactions may occur (most often itching, urticaria);
• There is likely to be a great craving for sleep, lethargy, a feeling of fatigue, inhibited reaction;
• Disorders in the work of the heart, tachycardia;
• Rarely, there are violations in the digestive system.

How to take pills correctly

The dosage of Pentalgin N depends on age:

• Children over 7 years old - half a tablet twice or thrice a day, immediately after meals;
• Adults - one tablet twice or thrice a day, also after meals.

The maximum dose of the drug per day is 4 tablets.

Duration of treatment: as an antipyretic - a maximum of 3 days, as an analgesic - a maximum of 5 days, unless otherwise prescribed by a doctor. In special cases, the doctor may prescribe a course of a maximum duration of 7 days.

Overdose

In case of an overdose, a person may experience some or all of these symptoms: nausea, sometimes vomiting, severe stomach cramps, loss of strength, drowsiness, delirium, abnormal heartbeat, sudden attacks of tachycardia.

For treatment with an overdose of Pentalgin N, it is worth taking the following measures, depending on the condition: stimulate vomiting, rinse the stomach with a probe, take Activated carbon or other intestinal adsorbents, carry out symptomatic therapy.

When undergoing treatment with Pentalgin N, follow these basic rules:

• Try not to drink strong tea and coffee on the days you take the drug. This will help avoid caffeine overdose.
• If, according to the indicated treatment, you drink tablets for more than 7 days, it is mandatory to periodically undergo an examination with a doctor. Such a long-term use can adversely affect the functioning of the liver. Without prior consultation, the drug is allowed to take a maximum of 3 days.
• Avoid pills if you are an athlete and are planning to take a doping test.
• If you have gastric diseases, taking Pentalgin N can distort the picture of the disease and complicate the diagnosis. Avoid it during treatment.
• Do not take pills if your profession involves driving a car or dangerous machinery that requires attention and concentration.

1 tablet contains:

• Active substances: metamizole sodium - 300 mg; naproxen - 100 mg; caffeine - 50 mg; phenobarbital - 10 mg; codeine (in the form of phosphate) - 8 mg;
• Excipients: potato starch, low molecular weight polyvinylpyrrolidone (povidone), sodium citrate, magnesium stearate.

10 pieces. - cellular contour packings (1) - packs of cardboard.

Description of the dosage form

Tablets are white or white with a yellowish or creamy tint, flat-cylindrical, with the abbreviated name of the drug "PENT-N" embossed on one side.

pharmachologic effect

Anti-inflammatory, antipyretic, analgesic, antispasmodic, sedative.

It has the properties of sedatives (phenobarbital), non-narcotic analgesics and NSAIDs (metamizole, naproxen), enhanced by codeine (blocks opiate receptors) and caffeine (increases the permeability of histohematic barriers).

Pharmacokinetics

The components of the drug are well absorbed in the gastrointestinal tract.

Metamizole sodium

In the intestinal wall, it is hydrolyzed to form the active metabolite, 4-methyl-amino-antipyrine, which in turn is metabolized to 4-formyl-amino-antipyrine and other metabolites. The binding of the active metabolite to proteins is 50-60%. Metabolites are excreted by the kidneys and excreted in breast milk.

Naproxen

Bioavailability is 95%. Binds to blood proteins. T1 / 2 - 12-15 hours. Excreted in the urine mainly as a metabolite (dimethylnaproxen), in small quantities - with bile.

Well absorbed in the intestines. T1 / 2 - 5 hours (sometimes up to 10 hours). It is excreted mainly by the kidneys in the form of metabolites, about 10% - unchanged.

Slightly binds to plasma proteins. Undergoes biotransformation in the liver (10% by demethylation passes into morphine). Excreted by the kidneys (5-15% - unchanged).

Phenobarbital

Bioavailability is 80%. Plasma protein binding - 50%. It penetrates well through the placental barrier. Biotransformed in the liver. The main metabolite has no pharmacological activity. Excreted by the kidneys, incl. 20-25% - unchanged.

Pharmacodynamics

The combined drug has analgesic, antipyretic and anti-inflammatory effects.

Metamizole sodium is an analgesic-antipyretic, a derivative of pyrazolone. It has a pronounced analgesic effect.

Naproxen - NSAIDs, has anti-inflammatory, analgesic and antipyretic effects associated with non-selective suppression of COX activity, which regulates the synthesis of prostaglandins.

Caffeine causes vasodilation of skeletal muscles, brain, heart, kidneys. Increases mental and physical performance, helps eliminate fatigue and drowsiness. Increases the permeability of histohematic barriers and increases the bioavailability of non-opioid analgesics, thereby enhancing the therapeutic effect.

Codeine stimulates opioid receptors in various departments CNS, which leads to the activation of the antinociceptive system and a change in the emotional perception of pain.

Phenobarbital and codeine increase the analgesic effect of metamizole sodium and naproxen.

Indications for use Pentalgin-n

Moderate pain syndrome: toothache and headache, myalgia, arthralgia, sciatica, neuralgia, algomenorrhea, etc.; febrile conditions, colds and other diseases accompanied by pain and inflammation.

Contraindications to the use of Pentalgin-n

Hypersensitivity, peptic ulcer of the stomach and duodenum (in the acute stage), blood diseases, conditions accompanied by respiratory depression, increased intracranial pressure, traumatic brain injury, acute myocardial infarction, cardiac arrhythmia, hypertension, alcohol intoxication, acute attack of bronchial asthma, glaucoma, severe liver and / or kidney dysfunction, pregnancy, breastfeeding, children under 12 years of age.

Pentalgin-n Use in pregnancy and children

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Pentalgin-n side effects

From the nervous system and sensory organs: dizziness, drowsiness.

From the side of the cardiovascular system and blood (hematopoiesis, hemostasis): granulocyto- or leukopenia, agranulocytosis.

From the digestive tract: nausea, vomiting, constipation, erosive and ulcerative lesions of the gastrointestinal tract.

Allergic reactions: skin rash, itching, urticaria.

Precautionary measures

Precautions should be prescribed in case of impaired liver and kidney function, gastric ulcer and duodenal ulcer (in remission), elderly patients. With prolonged use, it is necessary to control the composition of peripheral blood. During therapy, alcohol should be avoided and administered with caution to drivers during work Vehicle and people whose profession is associated with increased concentration of attention.

A complex drug with analgesic, antipyretic and anti-inflammatory effects. What is the composition and recipe in Latin "Pentalgin-N" has?

The drug is produced in tablet form. Tablets have a flat-cylindrical shape, color from milky to yellowish. Tablets are packed in contour cells of ten pieces, in total there are one or two blisters in the package.

The preparation contains the following active ingredients:

• analgin - three hundred milligrams;
• naproxen - one hundred milligrams;
• caffeine - fifty milligrams;
• phenobarbital - ten milligrams;
• codeine - eight milligrams.

In addition to active substances, the structure of the drug includes the following components:

• starch;
• povidone;
• sodium salt of citric acid;
• magnesium stearate.

What properties does "Pentalgin-N" have?

The composition of the drug includes the main substances that have analgesic, antipyretic, anti-inflammatory and sedative effects.

Metamizole sodium is considered a derivative of pyrazolone. The substance has an analgesic and antispasmodic effect. Naproxen has antiperitic, analgesic and antipyretic effects, which are due to non-selective slowing down of cyclooxygenase activity, which is responsible for the production of prostaglandins from omega-6, an unsaturated fatty acid.

Caffeine helps dilate skeletal blood vessels muscle tissue, heart, increase physical and mental performance, reduce fatigue and drowsiness. By increasing the permeability of blood-tissue barriers and increasing the bioavailability of non-narcotic painkillers, caffeine leads to an increase in their pharmacological effects.

Codeine has the ability to activate opioid nerve endings in various parts of the nervous system, which leads to the active functioning of the antinociceptive system and an improvement in the perception of pain on an emotional level.

Phenobarbital and codeine have an enhanced analgesic effect. Metamizole sodium and naproxen are remarkably absorbed in the stomach and intestines. Approximately fifty to sixty percent of active metabolic products bind to blood plasma proteins. The components of the drug may enter breast milk. Metabolites are excreted in urine.

The bioavailability of naproxen is ninety-five percent, and it binds to plasma proteins. The half-life is twelve to fifteen hours. It is excreted mainly by the kidneys, with bile - in small quantities.

Caffeine is well absorbed in the intestines. It is excreted mainly with urine in the form of metabolic products, unchanged - about ten percent.

The bioavailability of phenobarbital is about eighty percent, about fifty percent binds to plasma proteins. It has the ability to easily cross the placenta. The metabolic process is carried out in the liver with the appearance of metabolites. It is removed from the body with urine, including unchanged, by twenty or twenty-five percent.

Codeine binds to blood proteins in small quantities. Exchanged in the liver. It is excreted in the urine unchanged - only fifteen percent.

"Pentalgin-N" without a prescription is not dispensed from pharmacies.

Indications

"Pentalgin-N" is prescribed if available the following diseases and ailments:

1. Pain of various origins of weak and moderate strength.
2. Headache.
3. Neuralgia is a disease that is characterized by pain in the zone of greatest sensitivity of any nerve.
4. Migraine is a disease, the most common symptoms of which are episodic or regular excruciating attacks of headache.
5. Myalgia is muscle pain.
6. Radiculitis - lesions of the roots of the spinal cord, causing motor, vegetative and pain disorders.
7. Toothache.
8. Algodismenorrhea - painful menstruation, accompanied by a violation of the general condition.
9. Colds.

Contraindications

Like any other drug, "Pentalgin-N" has a number of contraindications for use, for example:

1. Kidney dysfunction.
2. Clinical Syndrome, which is characterized by a decrease in plasma hemoglobin.
3. Bronchial asthma - chronic inflammation respiratory organs.
4. Bronchospasm is a pathology that appears when the muscles of the bronchi contract.
5. Respiratory suppression.
6. A stomach ulcer is a chronic polyetiological pathology that occurs with the formation of ulcerative lesions in the stomach, a tendency to progression and the formation of complications.
7. Arterial hypertension- increase blood pressure.
8. Acute infarction myocardium - ischemic disease cardiovascular system, which proceeds with the occurrence of ischemic necrosis of the myocardium.
9. Arrhythmia.
10. Childhood up to twelve years old.
11. Pregnancy.
12. Breast-feeding.
13. Increased individual sensitivity to any component.
14. Elderly age.

How to take the drug correctly?

"Pentalgin-N" is taken orally. It is recommended to take one capsule up to three times a day. The maximum daily dose of the drug is four tablets. Without the appointment of a medical specialist, you can not take the medication for more than five days as an anesthetic and for more than three days as an antipyretic drug. When prescribing Pentalgin-N, a doctor must write a prescription.

Adverse reactions

Pentalgin-N tablets, if used improperly, can cause undesirable effects in the human body, for example:

1. Dizziness.
2. Drowsiness.
3. Nausea.
4. Vomit.
5. Constipation - delayed, difficult or systematically insufficient defecation.
6. Granulocytopenia - a decrease, below the accepted norm, in the number of granulocytes with a general decrease in leukocytes in plasma.
7. Leukopenia is a decrease in the concentration of leukocytes in the blood.
8. Agranulocytosis is a pathology in which there is a decrease in the number of leukocytes due to granulocytes.
9. Kidney disorders.
10. Urticaria is a skin disease that is characterized by the rapid onset of itchy blisters.

Overdose

In case of drug poisoning, the following symptoms may occur:

1. Nausea.
2. Gastralgia is an unpleasant feeling associated with actual or potential tissue damage.
3. Heart rhythm disorders.
4. An increase in heart rate of ninety beats per minute.
5. Delusion is a disorder of thinking, which is characterized by the appearance of things that do not correspond to reality and cannot be corrected.
6. Respiratory depression.

Therapy for overdose consists in inducing vomiting, as well as gastric lavage and taking adsorbents. At the same time, it is possible to complex treatment which is aimed at maintaining the work of vital organs.

Peculiarities

During the use of Pentalgin-N, it may be difficult to make a diagnosis in acute abdominal pain syndrome. In patients with seasonal allergic rhinoconjunctivitis and atopic bronchial asthma when using the drug, the risk of developing hypersensitivity reactions increases.

Poi long (more than five days) use of the drug should monitor the functioning of the liver and peripheral blood patterns. During the use of the drug, the results of doping control in athletes may vary.

Since "Pentalgin-N" can provoke such negative reactions as dizziness and drowsiness, when using capsules, you must refrain from driving a car and performing activities that require heightened attention and fast response. "Pentalgin-N" is released according to a prescription in Latin from a medical specialist.

Can the drug be used during pregnancy?

According to the instructions for use "Pentalgin-N" is forbidden to use during the "interesting position" and breastfeeding. If it is necessary to take the drug during lactation, feeding should be stopped and the child should be transferred to milk formulas.

Children under the age of twelve "Pentalgin-N" is contraindicated. In addition, it is not recommended to use the drug for people suffering from severe kidney failure and liver. Patients of retirement age must be especially careful when taking the drug. The drug "Pentalgin-N" is released according to a prescription in Latin.

Interaction

Taking "Pentalgin-N" together with certain medications can lead to the following reactions:

• With the means there is an increase in intoxication. Simultaneous use with allopurinol, tricyclic drugs, oral birth control pills provokes an increase in the toxicity of metamizole sodium.
• Phenylbutazone and barbiturates, together with Pentalgin-N, cause a weakening of the effects of metamizole sodium. The use of the drug with cyclosporins lowers the level of the second substance in the blood.
• Simultaneous reception with tranquilizers and sedatives medicines contribute to the enhancement of the analgesic effect of "Pentangin-N".

Analogues

The following medicines are considered substitute drugs:

1. "Piralgin".
2. "Efferalgan".
3. "Baralgin M".
4. "Maxigan".
5. "Spazgan".
6. "Spasmalin".
7. "Sedalgin plus".
8. "Ibuprofen".
9. "Tetralgin".
10. "Banalgin".

Storage conditions

It is necessary to keep "Pentalgin-N" in a place protected from light at a temperature of no more than twenty-five degrees. Keep away from children. The expiration date is thirty-six months. Sample recipe for "Pentalgin-N":

Rp.: Codeini 0.008

Metamizoli Sodium 0.3

Phenobarbital 0.01

S: 1 tablet for pain.

Opinions

There are a huge number of reviews about Pentalgin-N, and in most cases they are positive. Absolutely all patients who wrote responses, the medication helped to eliminate pain of various etiologies.

Capsules have also proven to be excellent as an antipyretic drug for colds. People note that the drug acts instantly, the analgesic effect persists for quite a long time. Many users prefer to keep this medicine in their home medicine cabinet. The price of "Pentalgin-N" varies from 200 to 300 rubles.