Afobazole - instructions for use and contraindications. Afobazole - instructions for use, composition, indications, form of release, side effects, analogues and price From which tablets afobazole 10 mg

A person does not always manage to cope with his emotions, so he has to improve his health with the help of special drugs. The anxiolytic afobazole allows you to get rid of an unreasonable feeling of fear, remove chronic fatigue, irritability and nervousness. It, like any other medicine, must be taken as prescribed by the doctor.

The composition of Afobazole and the release form

The drug is available in the form of white or cream-colored tablets with a chamfer in the middle. Dosage - 5, 10 mg. Active ingredient: fabomotizole . Under its influence, impulses of nervous excitation are stopped.

As auxiliary substances are used:

Ordinary potato starch.
Microcrystalline cellulose.
magnesium stearate.
Lactose.
Povidone. In addition to the connecting role, this ingredient is also an absorbent - it binds together toxins in the intestines and removes them from the body.

What group of drugs does it belong to?

The sedative Afobazol belongs to the category of anxiolytic drugs and is a tranquilizer that helps improve mood and increase energy. The sedative properties achieved when taken are not the main ones, but side ones. The main task of the drug is to normalize the functioning of nerve cells from the inside.

How Afobazole works on the body

The drug begins to act after the first dose, but the patient notices the therapeutic effect on about the 5th day of treatment. The quality of sleep gradually improves, the feeling of anxiety decreases. This is due to the fact that the main substance has a cumulative effect: the functions of nerve cells are slowly restored during the first week of therapy.

withdrawal syndrome

If you suddenly stop taking certain drugs, the patient's condition may worsen. Often the symptoms that need to be eliminated appear with a vengeance and are supplemented by new signs.

If you refuse to take Afobazol, such situations are not observed.

Indications for use

Neurasthenia, emotional, behavioral, anxiety disorders.
Insomnia (even chronic). The drug is effective if the problem is caused by constant anxiety, stress or nervous strain.
"Withdrawal syndrome" after smoking cessation. Giving up a long-standing habit, a person gets into a state of stress, which helps to eliminate Afobazol.
Premenstrual syndrome.
Alcohol withdrawal syndrome observed in stages II and III. Manifested in the form of mental, neurological and somatic disorders.
Oncology (in complex therapy to support the psychological state of the patient).

How to take Afobazol

The drug is intended for oral use.
Afobazole should be taken after meals. Especially if the patient has problems with digestive system.
Tablets do not need to be chewed or sucked. They should be swallowed whole with a small amount of water slowly.
The drug is sold without a prescription, is contraindicated in children.

Maximum daily dose

A single dosage should not exceed 10 mg, daily - 30 mg. Adolescents from 18 years of age are prescribed a maximum dose of 20 mg. In severe forms of psycho-emotional disorders daily rate may be increased to 60 mg.

Duration of admission

To achieve a therapeutic effect, and not just eliminate the symptomatic picture, Afobazol soothing tablets must be taken for 2-3 weeks.

Is it possible to drive Afobazol

The drug does not cause drowsiness and does not affect concentration. Many anti-anxiety drugs provoke muscle relaxation - a condition in which muscle tone decreases significantly, a person becomes inattentive.

The drug Afobazol does not have such an effect, therefore it may well be used by drivers.

Compatibility with other drugs and alcohol

Even a minimal dose of alcohol can enhance the effect of a tranquilizer, which is fraught with poisoning, intoxication, or even an overdose. Before starting treatment, it is important to make sure that alcohol derivatives are eliminated from the body: at least 2 days must pass after taking strong drinks.

After the end of treatment, alcohol is prohibited for another 2 weeks.

Drug interaction:

Enhances the anxiolytic effect of Diazepam and the anticonvulsant effect of Carbamazepine. A treatment regimen with such a complex complex must be prescribed by an observing doctor.
It does not affect the narcotic effect of ethanol and the hypnotic effect of sodium thiopental.

The benefits and harms of Afobazole

With a complex, regular intake by a patient:

Symptoms of depression go away.
The mood improves.
Disappear anxiety, self-doubt.
Decreases shyness.
Sleep is normalized. A person forgets about insomnia and nightmares.

The drug can also harm people who have individual intolerance to the constituent components.

Taking the medication is fraught with a serious allergy or anaphylactic shock.

Side effects

Taking Afobazol can cause:

increased drowsiness;
allergy;
pain, dizziness;
increased sexual desire against the background of elimination of anxiety;
high muscle tone, which does not pass even after the general stabilization of the state of the nervous system.

After stopping all side effects pass.

Allergy to Afobazole

The cause of this phenomenon may be an individual intolerance to one or more components of the drug or its overdose, an incorrectly selected treatment regimen. The allergy resolves after the patient stops taking the antidepressant.

Symptoms of a negative reaction:

rashes, dry skin;
itching and burning;
redness.

Contraindications

Pregnancy.
lactation period.
The patient's age is up to 16 years.
Lactose intolerance - hypolactasia.
Diseases of the stomach in an acute form. With irritable bowel syndrome, this drug is prescribed, because. the cause of the problem lies in the work of the brain.
Allergic reactions.

Stressful situations await a person at every turn, and in order to bring nervous system in order, sometimes you have to resort to taking medication. Modern, popular sedatives include "Afobazol". The doctors' comments boil down to the fact that the drug is well tolerated by patients and is not addictive after prolonged therapy. The dosage is calculated individually in each case by the attending physician.

"Afobazole": general information

Depressants is a generic name for a group of medicines that affect the central nervous system. By origin, they are divided into vegetable and synthetic.

The ranks of selective anxiolytics were replenished with the drug "Afobazol". The instruction says that the side effects characteristic of the group of benzodiazipine tranquilizers are absent in this remedy. It has an anti-anxiety, activating effect and has a positive effect on the general condition. Taking the drug, you can not be afraid of the addiction of the body, memory impairment or the occurrence of a "withdrawal syndrome" after the completion of the course of treatment.

"Afobazol" - medicinal (psychotropic) product Russian production. The anxiolytic has several advantages over some antidepressants and benzodiazepine tranquilizers. The scientists who developed the drug declare that there are no negative consequences that usually accompany the treatment process with sedatives. "Afobazole", the composition of which does not cause a depressing, muscle relaxant effect, does not form drug dependence.

Clinical studies of Afobazole have confirmed its effectiveness. Both women and men aged 18 to 60 with neurotic disorders took part in the test. The first results of improving the emotional state and reducing feelings of anxiety were recorded as early as 3-10 days after the start of the drug.

After 6 weeks of therapy, almost all patients had a partial or complete remission. The tool is recognized as absolutely safe for use in any field of medicine. Despite the free sale in pharmacies, before use, you should consult a doctor to establish a diagnosis and prescribe a suitable treatment regimen.

Composition and form of release

To date, you can purchase a tablet form of the drug "Afobazol". The composition of each tablet is 5 or 10 mg of the active ingredient fabomotizole hydrochloride (morpholinoethylthioethoxybenzimidazole). Additional components - potato starch, magnesium stearate, lactose monohydrate, povidone.

How does the drug work?

The selective axolytic in the composition of the product helps to prevent changes in membrane-dependent receptors. This, in turn, helps to reduce the level of irritability, discomfort, anxiety, fear. Thanks to the drug, sleep is normalized, a rush appears vital energy physical condition is restored.

Symptoms of somatic disorders associated with the respiratory, cardiovascular, sensory, digestive systems eventually cease to manifest themselves and disturb the patient. The result of therapy should be evaluated at the 4th week of treatment, when the maximum effect of the drug "Afobazol" is achieved. Reviews of doctors indicate the stabilization of the level of blood pressure (stress often causes hypertension) after taking the remedy. Symptoms of an autonomic disorder (increased heart rate, tremors, shortness of breath, chest pain) are also reduced.

The effect of the drug persists for 2 weeks after the end of the intake. The patient ceases to feel constant fear and concern. Attacks of muscle twitches, dizziness are blocked, attention improves. Compared with benzodiazepines, the therapeutic effect is less pronounced.

When is Afobazol prescribed?

The use of a sedative is especially important for people suffering from a constant feeling of insecurity, suspiciousness, violent emotional manifestations in response to negative life situations. As part of complex therapy, it is prescribed to patients with bronchial asthma, hypertension, chronic insomnia, and oncological pathologies.

Reception of "Afobazol" is mandatory prescribed for the following problems:

neurasthenia and neuroses;
systemic lupus erythematosus (autoimmune disease);
ischemia of the heart;
dermatological diseases (psoriasis, eczema, lichen);
coding for alcohol addiction and smoking;
premenstrual syndrome;
irritable bowel syndrome;
oncological pathologies;
anxiety state;
cardiopsychoneurosis.

The drug can be used during periods of increased excitement, for example, before passing exams or when changing jobs. For each patient, an individual therapy regimen and dosage of the drug "Afobazol" are signed. Analogs means contain other active substances, but have the most similar therapeutic effect. The drug that is optimal for therapy can only be selected by a specialist, having previously examined the patient.

How to take "Afobazol"?

The instruction to the medication is an important document that every patient should read before starting to use the remedy. According to the annotation, the tablets are taken after meals. The optimal single dose is 10 mg. If necessary, the attending physician can correct this value. Depending on the diagnosis, it varies both up and down. Drink a sedative 3 times a day at approximately the same time interval. The maximum duration of admission is 3 months, after which it is necessary to take a break.

For a short course of treatment, you can buy the drug in a carton of 10 or 20 tablets. It is also available in tins of 50 and 100. It is better to use such a volume if long-term therapy with Afobazole is necessary. The price starts from 280 rubles. and depends on the dosage of the active substance.

The result of using the remedy manifests itself at different times. In some patients, an improvement in the emotional state is observed already on the third day of admission, in others - a little later. The drug is well absorbed from the intestinal walls and quickly excreted from the body.

"Afobazol": contraindications

Despite the relative safety and non-toxicity of the components, the drug is still forbidden to be taken during pregnancy and lactation. Children under 18 years of age should not be taken without a prescription from the attending physician. Persons with individual intolerance to its constituent substances should refrain from using the drug.

Some patients note the appearance of drowsiness after taking the sedative Afobazole. Reviews of doctors confirm the appearance of such symptoms only in the case of an independent increase in the recommended daily dose. If you follow the instructions of a specialist, the drug helps to improve concentration. Therefore, it is approved for use if it is necessary to control mechanisms.

Side effects

The development of an allergic reaction is possible if the body is intolerant to lactose, which is part of the drug "Afobazol". Overdose is rare and manifests itself in the form of a significant sedative effect. Due to the fact that the drug is quickly excreted from the body, this condition usually goes away on its own. Sometimes it may be necessary to inject caffeine (sodium benzoate) subcutaneously.

At the beginning of therapy, an undesirable reaction to Afobazole may appear. Side effects in the form of nausea and vomiting disappear after discontinuation of the drug. If symptoms persist, seek medical attention.

Is the drug compatible with alcohol?

This question interests almost everyone who takes a sedative. Light tranquilizer "Afobazol" and alcohol are quite compatible. The components of the drug do not increase the narcotic effect of ethanol, but rather, on the contrary, suppress it. Therefore, intoxication from a small amount of high-grade drinks can not be felt. In turn, alcohol does not have the best effect on the healing process and reduces its effectiveness.

Anxiolytic "Afobazol" and alcohol are undesirable to take at the same time. The drug is often used in the treatment of withdrawal syndrome, when it is difficult for the patient to endure the refusal to drink alcohol or nicotine. This tool makes it easier to transfer this period. It also helps to relieve hangover syndrome, "starting" the work of the central nervous system.

Interaction with other drugs

If several sedatives are used simultaneously for treatment, the effect is not always more pronounced. It does not make sense to take "Afobazol" with light sedative drugs based on medicinal herbs.

Most often, it is enough to take only Afobazol. Compatibility with other tranquilizers or nootropics will manifest itself in the form of a pronounced anti-anxiety effect. Epilepsy drugs will work more strongly.

What to replace?

Today, pharmaceutical companies offer a wide range of sedative drugs, both natural and synthetic origin. If necessary, you can choose a substitute for the drug "Afobazol". Analogues will have other active ingredients in the composition, but the therapeutic effect will be identical. Medicines that can relieve anxiety and confusion syndromes include:

"diazepam";
"Adaptol"
"Phenazepam";
"Elinium";
"Amizil";
"Atarax";
"Tenotin";
"Persen";
"Mebix";
"Phenibut";
"Tranquezipam";
"Neurofazol" (synonymous with the drug "Afobazol").

Substitutes have a similar therapeutic effect, but they cannot be compared with the original remedy. The attending physician should select the optimal remedy, taking into account the patient's diagnosis and the presence of individual intolerance to the components. It is quite difficult to cope with the manifestation of neurosis on your own, because drugs can only remove the symptoms of the disease, but not solve the cause of the problem.

What are patients and doctors saying?

Various life circumstances always "hit" the nerves, provoke the occurrence of panic attacks, depression, fear of tomorrow. Not everyone is able to cope with depression and tantrums. For help in such situations, you should contact a neurologist. Many specialists prefer to prescribe a "light" tranquilizer "Afobazol" to their patients. The doctors' comments on the drug were mostly positive, although some consider this to be a placebo effect, despite the huge number of people to whom the anxiolytic returned good health and a stable emotional state. Sick, suffering constant feeling anxiety and anxiety-prone, say that the remedy really helps and suppresses unpleasant symptoms, if the case is not neglected.

Most of the patients who used the drug note a rapid therapeutic effect Literally from day one. Stop panic attacks, which are often accompanied by tachycardia and spasm in the chest and throat. A calm state allows you to correctly assess the situation and find ways to resolve problems.

Negative reviews are quite rare and are mainly associated with the appearance of side effects. Some patients did not feel any changes psychological state for the better after taking Afobazol. An anxiolytic overdose is practically impossible if the neurologist's instructions are fully observed and the dosage is not exceeded.

Should I take "Persen" instead of "Afobazole"?

"Persen" is a plant-based sedative. It contains mint leaves, lemon balm, medicinal valerian root extract. Natural origin has a positive effect on the symptoms of anxiety, irritability, promotes normal sleep without bouts of daytime sleepiness. When choosing "Afobazol" or "Persen" for treatment, it should be borne in mind that the effect of the first is lighter compared to a synthetic anxiolytic.

A plant-based sedative can be used in pediatrics under the strict supervision of a physician. "Persen" improves attention, calms and helps to cope with insomnia. It can be prescribed in complex therapy for vegetovascular dystonia, the syndrome of withdrawal of potent drugs. As a preventive measure, it is recommended during periods of constant stressful situations.

A specialist should choose between two sedatives. In milder cases, it is sometimes sufficient to take an herbal sedative. If the situation requires "serious" medicines, the patient is prescribed "Afobazol". Contraindications to the use of "Persena" - increased arterial pressure, pregnancy, children under 3 years of age and individual intolerance to the components.

"Afobazol" or "Adaptol"?

The sedative "Adaptol" belongs to the group of anxiolytics and has the same therapeutic effect as "Afobazol". The use is indicated for neurosis, emotional instability, stress of various etiologies. Helps reduce cravings for nicotine and improves tolerance to antipsychotics.

Clinical trials have confirmed the positive effect of the drug on mental activity. "Adaptol" also improves the reaction rate when controlling various mechanisms and does not cause daytime drowsiness. The active substance of the drug is mebicar (one capsule contains 300 mg). Does not cause addiction and addiction.

The tool is not allowed to be taken by children under 10 years old, pregnant and lactating women. Side effects (dizziness, weakness) develop only when the recommended dose of Adaptol is significantly exceeded.

Many patients who first took Afobazole and then Adaptol noted that the sedative effect of the latter was weaker. "Afobazole" really has a pronounced anti-anxiety effect. He is able to cope with the symptoms of a panic attack, overcome the feeling of fear and eliminate autonomic disorders (dry mouth, sudden dizziness). It makes sense to take the Latvian analogue only in mild cases, with minor neurological disorders.

Is it possible to replace "Afobazol" with "Fenibut"?

The drug "Fenibut" refers to nootropic drugs, derivatives of gamma-aminobutyric acid. Able to cope with tension, anxiety, anxiety. Promotes the activation of mental abilities and helps to concentrate. This is due to improved blood supply to the brain tissue. The product is non-toxic and completely safe. It is excreted from the body within 3 hours after ingestion. Despite some positive aspects of the remedy, it is worse tolerated by patients and often causes undesirable consequences and addiction to the system, unlike Afobazol.

The price is of no small importance when choosing a drug, and Phenibut can be safely called an affordable medicine compared to an anxiolytic latest generation(cost - about 120 rubles). It should be borne in mind that during the treatment of data sedative it is forbidden to consume alcoholic beverages. Phenibut and ethanol have the same effect and inhibit the work of the central nervous system. Quite often, the drugs "Afobazol" and "Fenibut" are prescribed for the treatment of chronic alcoholism, when the patient suffers from memory impairment, loses interest in life, and experiences withdrawal symptoms.

Compared with "Afobazol", contraindications to the use of "Fenibut" are somewhat expanding. The drug, according to the instructions, is taken with caution in case of peptic ulcer and hepatic pathologies. Under the strict supervision of a physician, a sedative is used in the treatment of children under 8 years of age. During pregnancy, the manufacturer advises to refrain from using the product, since there are no data on such studies. With symptoms of an overdose (drowsiness, bouts of vomiting, low blood pressure), it is urgent to flush the stomach.

Afobazole is an anxiolytic (anxiety-reducing) medicinal product, which appeared in domestic pharmacies in the early 2000s. The drug is intended mainly for sedative purposes. The active ingredient of the drug is afobazole.

Pharmacological action of Afobazole

According to the instructions, Afobazol reduces anxiety and calms. The use of the drug does not cause either psychological or physical dependence in the patient, even with prolonged use. Also, reviews of Afobazol confirm that the remedy does not negatively affect concentration and memory, does not reduce muscle tone, so it can be used at any time of the day and under any circumstances. When taking the drug, there is no withdrawal syndrome, in other words, if the treatment is abruptly stopped, the patient's condition will not worsen in any way.

From the instructions for Afobazole, you can find out that the drug produces a double effect - it relieves feelings of anxiety and has a slight stimulating effect. The elimination of nervous tension and anxiety has a beneficial effect on the psychological and physical condition of the patient. The action of the drug, which is aimed at reducing feelings of anxiety, allows you to stop the symptoms of muscle, cardiovascular, respiratory and gastrointestinal failures present in somatic disorders. Many reviews of Afobazole do not deny that the drug reduces the frequency of autonomic disorders: dry mouth, sweating and dizziness.

The use of Afobazole helps to increase concentration and improve memory.

Positive changes in the body are already observed on the 5th-7th day of taking the drug. The maximum effect can be felt after 3-4 weeks of treatment, and it lasts for 1-2 weeks. But this figure depends on the metabolic rate of each patient individually. Reviews about Afobazole also indicate that the drug is excellent for people who suffer from increased vulnerability, emotional instability, suspiciousness, and self-doubt.

The drug is non-toxic, which is confirmed by studies conducted on animals.

According to the instructions, Afobazole is absorbed very well in the gastrointestinal tract, has a high degree of binding to blood plasma proteins. The drug is quickly excreted from the body.

Indications for the use of Afobazole

Afobazole is prescribed for:

anxiety conditions such as adjustment disorders, neurasthenia, general anxiety disorders;
oncological and dermatological diseases (according to the doctor's indications);
somatic diseases such as bronchial asthma, irritable bowel syndrome, hypertension, systemic lupus erythematosus, ischemia, arrhythmia;
sleep disorders;
premenstrual syndrome;
neurocirculatory dystonia;
alcohol withdrawal syndrome;
giving up cigarettes to alleviate the condition.

Method of application of Afobazole and dosage

Dosages are selected individually depending on the type and severity of the disease, as well as the general condition of the patient.

As a rule, the dose of Afobazole at the initial stage of treatment is 10 mg per dose, the daily dose is 30 mg. If necessary, the dosage is increased to 60 mg during the day. The duration of treatment is on average 2-4 weeks, but in some cases the doctor extends it to 3 months or prescribes a second course after a while.

Side effects of Afobazole

Taking Afobazole sometimes leads to side effects such as:

disorders of the gastrointestinal tract: vomiting, diarrhea, nausea;
allergic reactions: rash, redness, urticaria, itching on the skin.

Contraindications to the use of Afobazole

The remedy is also contraindicated for lactose intolerance - hypolactasia.

Afobazole and alcohol

When treating with Afobazol, alcohol is not strictly prohibited, since the drug does not enhance the narcotic effect of drinks and does not provoke poisoning. However, it is not recommended to combine the drug with drinks containing alcohol, since the effectiveness of treatment is reduced to almost zero.

Also, the use of alcohol and Afobazole by women in the treatment of hormonal disruptions does not lead to positive results.

Afobazole storage conditions

The drug should be stored in a dark, dry place at an air temperature not exceeding 25 degrees. Shelf life is 2 years, after which the product can not be used.

INSTRUCTIONS
on medical use drug

Registration number:

LS-000861

Trade name of the drug: AFOBAZOL ®

Chemical rational name:
5-ethoxy-2-benzimidazole dihydrochloride.

Dosage form:

tablets.

Composition:

Each tablet contains:

Active substance: afobazole (in terms of dry matter) - 5 mg or 10 mg.

Excipients: potato starch, microcrystalline cellulose, milk sugar (lactose), povidone, magnesium stearate.

Description: Tablets of white or white color with a creamy tint, flat-cylindrical shape with a chamfer.

Pharmacotherapeutic group:

anxiolytic.

ATC code: N05BX.

Pharmacodynamics

AFOBAZOL® is a 2-mercaptobenzimidazole derivative, a selective anxiolytic that does not belong to the class of benzodiazepine receptor agonists. Prevents the development of membrane-dependent changes in the GABA receptor.

AFOBAZOL® has an anxiolytic effect with an activating component that is not accompanied by hypnosedative effects (sedative effect is detected in AFOBAZOL® at doses 40-50 times higher than the ED 50 for anxiolytic action). The drug has no muscle relaxant properties, a negative effect on memory and attention. With its use, drug dependence is not formed and withdrawal syndrome does not develop. The action of the drug is realized mainly in the form of a combination of anxiolytic (anti-anxiety) and easily stimulating (activating) effects.

Reduction or elimination of anxiety (concern, apprehension, apprehension, irritability), tension (shyness, tearfulness, anxiety, inability to relax, insomnia, fear), and therefore somatic (muscular, sensory, cardiovascular, respiratory, gastrointestinal symptoms), vegetative (dry mouth, sweating, dizziness), cognitive (difficulties in concentrating, impaired memory) disorders are observed on days 5-7 of treatment with AFOBAZOL®. The maximum effect is achieved by the end of 4 weeks of treatment and persists in the post-therapeutic period for an average of 1-2 weeks. Especially indicated is the use of the drug in persons with predominantly asthenic personality traits in the form of anxious suspiciousness, uncertainty, increased vulnerability and emotional lability, a tendency to emotional stress reactions. AFOBAZOL® is non-toxic (LD 50 in rats is 1.1 g with ED 50 0.001 g).

Pharmacokinetics
The half-life of AFOBAZOL® when taken orally is 0.82 hours, the average maximum concentration (Cmax) is 0.130 ± 0.073 μg / ml; the average retention time of the drug in the body (MRT) - 1.60±0.86 hours. AFOBAZOL® is intensively distributed over well-vascularized organs.

Indications for use
AFOBAZOL® is used in adults with anxiety conditions: generalized anxiety disorders, neurasthenia, adjustment disorders, in patients with various somatic diseases (bronchial asthma, irritable bowel syndrome, systemic lupus erythematosus, ischemic disease hearts, hypertonic disease, arrhythmias), dermatological, oncological and other diseases. In the treatment of sleep disorders associated with anxiety, neurocirculatory dystonia, premenstrual syndrome, alcohol withdrawal syndrome, to alleviate the withdrawal syndrome when quitting smoking.

Contraindications
Pregnancy, lactation. Individual intolerance to the drug. Childhood up to 18 years old.

Dosage and administration
It is applied inside, after eating. Optimal single doses of the drug - 10 mg, daily - 30 mg, divided into 3 doses during the day. The duration of the course of the drug is 2-4 weeks. If necessary daily dose the drug can be increased to 60 mg, and the duration of treatment up to 3 months.

Side effects
Increased individual sensitivity, allergic reactions are possible.

Overdose
With a significant overdose and intoxication, the development of a sedative effect and increased drowsiness without manifestations of muscle relaxation is possible. As emergency care caffeine sodium benzoate 20% solution in ampoules of 1.0 ml is used 2-3 times a day subcutaneously.

Interaction with other drugs
AFOBAZOL® does not affect the narcotic effect of ethanol and the hypnotic effect of thiopental. Potentiates the anticonvulsant effect of carbamazepine. It causes an increase in the anxiolytic action of diazepam.

Release form
10 tablets or 25 tablets in a blister pack made of PVC film and aluminum foil.

30,50 or 100 tablets in a polymer jar complete with lids. Each bank or 3, 5 or 10 contour packs of 10 tablets, or 2 or 4 contour packs of 25 tablets together with instructions for use in a cardboard pack.

Storage conditions
In a dry, dark place, at a temperature not exceeding +5°C. Keep out of the reach of children.

Best before date
2 years. Do not use after the expiration date indicated on the package.

Terms of dispensing from pharmacies
Without a doctor's prescription.

Afobazole belongs to the category of anxiolytics, that is, drugs that fight anxiety disorders.

He successfully fights tearfulness, sleep disturbances caused by the inability to relax, constant and unreasonable expectation of bad developments, and some other symptoms.

On this page you will find all the information about Afobazole: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Afobazole. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Tranquilizer (anxiolytic).

Terms of dispensing from pharmacies

Approved for dispensing from pharmacies without a prescription. Before use, you should consult with a specialist.

Prices

How much does Afobazol cost? The average price in pharmacies is at the level of 400 rubles.

Release form and composition

Afobazole is available in tablets. This is the only form of drug production. In cardboard packaging, as in the photo, blisters with tablets made of aluminum alloy and transparent plastic are placed.

Each of them has:

the shape of a flat cylinder with a chamfer;
color - white or creamy.

The main thing active substance- morphodihydrochloride. Its amount depends on the dosage of the tablet - 5 or 10 mg. As auxiliary components providing the structure, are:

povidone medium molecular weight;
potato starch;
magnesium stearate;
lactose monohydrate;
microcrystalline cellulose.

Pharmacological effect

Afobazol refers to sedative drugs that reduce anxiety. The use of Afobazole does not lead to dependence on the drug, even with a fairly long-term use. The drug does not adversely affect memory and concentration, does not reduce muscle tone, which is also confirmed by reviews of Afobazole. When taking Afobazole, there is no withdrawal syndrome, that is, with a sharp cessation of taking the drug, the patient's condition does not worsen.

Positive dynamics of the state is observed on the 5-7th day after the start of the drug. The maximum effect occurs after 3-4 weeks and persists for another 1 or 2 weeks, depending on the metabolic state of a particular patient. Afobazole helps patients who are worried about suspiciousness, increased vulnerability, emotional instability, self-doubt. A good effect from the use of the drug is also proved by positive reviews.

This tranquilizer has a dual effect: it relieves feelings of anxiety and provides mild stimulation. Reducing the state of anxiety and nervous tension leads to an improvement in both the mental and physical condition of the patient. The action of the drug, aimed at reducing anxiety, allows you to eliminate the symptoms (muscular, respiratory, cardiovascular, gastrointestinal), which are present in somatic disorders. It also reduces the frequency of autonomic disorders (sweating, dry oral cavity, dizziness).

Indications for use

In general, indications for the appointment of Afobazole are any anxiety states in adults, such as:

premenstrual tension syndrome;
withdrawal syndrome during smoking cessation;
general anxiety disorder, adjustment disorder;
alcohol withdrawal syndrome;
somatic conditions, which can also be accompanied by anxiety and depression (, oncopathology);
sleep disorders.

The drug is especially indicated for the treatment of people with predominantly asthenic individual traits, which are manifested by anxious suspiciousness, lack of self-confidence, vulnerability, emotional instability, and a tendency to stress. Afobazole is also prescribed quite often, allowing you to eliminate the unpleasant symptoms of hormonal changes in the female body, which are often manifested by nervousness and anxiety, autonomic disorders.

Is it a tranquilizer or not?

Yes, Afobazole belongs to the group of selective anxiolytics - tranquilizers. The drug has a mild effect, is not addictive. It differs from the more severe benzodiazepine non-selective tranquilizers in terms of safety, while:

does not relax the muscles of the body;
does not impair attention and memory;
does not have a withdrawal syndrome after the end of the course of treatment.

Contraindications

glucose-galactose malabsorption;
pregnancy and lactation;
galactose intolerance;
lack of lactose;
the drug is not used to treat patients under 18 years of age.

Use during pregnancy and lactation

The use of the drug is contraindicated during pregnancy.

If necessary, the use of the drug during lactation breast-feeding should be stopped.

Instructions for use

The instructions for use indicate that Afobazole is prescribed for adults inside after meals.

Usually used 1 tablet 3 times a day. The maximum daily dose is 60 mg.

The duration of treatment is 2-4 weeks. According to the doctor's prescription, treatment can be increased up to 3 months.

Side effects

As side effects, Afobazole can provoke various allergic reactions and headache, which, as a rule, passes on its own, without requiring special treatment and discontinuation of the drug.

Some people note the appearance of a pronounced sexual desire a few days after the start of taking Afobazole. Doctors and scientists do not attribute this effect to a side effect, but associate the appearance of libido with relief of tension and anxiety.

Overdose

With a significant excess of the recommended therapeutic dose of Afobazole tablets, an excessive sedative and hypnotic (hypnotic) effect develops without muscle relaxation. In this case, a 20% solution of caffeine-sodium benzoate is used as an antidote, 1 ml 2-3 times a day.

special instructions

The drug does not affect the ability to drive a car and potentially dangerous mechanisms, so the answer to the question “Is it possible to take Afobazol while driving?” positive. It is also not forbidden to take the remedy to people employed in hazardous industries and people whose work requires attentiveness and accuracy of reactions.

drug interaction

Afobazole has no effect on the depriming effect of ethyl alcohol and the hypnotic (hypnotic) effect of sodium thiopental (an ultrashort-acting drug for inhalation anesthesia).

Potentiates the antiepileptic effect of Carbamazepine and enhances the tranquilizing effect of Diazepam.

Alcohol compatibility

Afobazole and alcohol do not interact with each other. Therefore, if you took pills, and in the evening a banquet or a party awaits you, where there will be alcohol, you can not worry. You are allowed to drink a glass of wine. But this does not mean at all that afobazole and alcohol, when used together, will act traditionally. There is no interaction only on the part of chemical reactions, but your individual reactivity of the body is unpredictable.

Afobazole and alcohol are compatible concepts when it comes to the treatment of withdrawal symptoms. In this case, the drug is desirable and helps to significantly alleviate the condition of the person. The therapeutic dose for withdrawal symptoms is 10-20 mg per dose, but not more than 60 mg per day.

In other cases, the maximum daily dosage is considered to be 30 mg.

Reviews

Reviews of patients and doctors about Afobazole are rather ambiguous, among them there are both positive and negative. Some doctors talk about the lack of effectiveness of the drug and prefer benzodiazepines, which guarantee relief from anxiety in 100% of cases, but have a lot of severe side effects, causing drug addiction. Other experts believe that Afobazole has a sufficient therapeutic effect and is good for patients who do not have deep and severe anxiety disorders.

We have selected some reviews of people about the drug Afobazol:

Irina . I have half of my friends on Afobazol, who during stress at work, who drink before the holidays, who have problems at home ... it helps everyone a lot! I feel that I myself will soon join their club of afobazole workers)) otherwise my nerves are not iron.
Pauline . I took afobazole for panic attacks. He does not completely solve the problem (in addition to the sedative, work on the lifestyle as a whole is also required, sometimes a psychologist's consultation is needed), but it helps to avoid seizures. The most acute period for me was in the summer. Heat, closeness, a lot of people - a panic attack immediately began, often reaching fainting. With afobazole, I successfully avoided such situations. After completing the entire course of treatment, the problem of PA no longer worries me, but I still resort to afobazole when I feel that the nerves are already at the limit in order to avoid relapses.
Hope. Afobazole helped me from overeating. Previously, in any stressful situation, I sat with a cookie, or a sandwich, or a chocolate bar, a roll ... in general, only food could calm me down and help put my thoughts in order. Of course, this "calm" resulted in a tidy number of extra pounds. I realized that I urgently needed to do something with my habit, on the advice of a friend I decided to drink afobazole (she lost weight on it, and the review was very tempting). I didn’t notice the changes right away, but after about a week it really became less drawn to the refrigerator. By the end of the course, I generally caught myself thinking that food now interests me only in moments of hunger. Well, yes, it’s a shame that I didn’t come to my senses earlier, so the surplus would be much less. Now goal number 2 is to lose weight!)
Barbara. I tried to quit smoking three times, but each time it broke me so much, as if I didn’t smoke cigarettes at all. Friends advised to combine the refusal with the course of Afobazol. And so she did. Generally a thing! It controls both nerves and appetite, it does not cause addiction, and I have something to compare with, without it it was very hard!
Veronica. My mother is constantly worried about her family. Words do not soothe, like everyone is fine. She says that everything is just to divert her eyes, but in reality everything is bad. It was because of her suspiciousness and anxiety that she persuaded her to start drinking Afobazol. What a relief. Now a person lives normally and does not torment himself with obsessive thoughts out of the blue.
Natalia . Took as prescribed by the attending endocrinologist for treatment increased function thyroid gland and its nodes (there was a rather serious constant stress background). Very well helped in my case, in combination with treatment with drugs for the thyroid gland.

Patients in most cases speak positively about Afobazol, noting that he helped them cope with difficult life situations, eliminating nervousness, panic attacks and constant disruptions to others. Many say that taking the drug helped get rid of vulnerability and self-doubt, develop a calm attitude to numerous problems and improved the quality of life.

Negative reviews about Afobazole are associated with two main factors - the ineffectiveness of the drug in a particular case and the development of side effects that were difficult to tolerate and forced to stop therapy. So, in some people, Afobazole did not normalize the condition and did not stop anxiety so much that they were comfortable, which naturally caused disappointment and negative feedback. In other people, Afobazole provoked daytime sleepiness, which forced them to stop taking the drug due to the inability to continue working.

Analogues

The most commonly used analogues of Afobazol are as follows:

Divaza- a drug that is part of the group of tranquilizers. During the reception, the active component normalizes the blood circulation of the brain, relieves tension, fatigue. It is taken during vegetative disorders, with disorders of the brain that are caused by trauma, ischemic diseases, neurodegenerative diseases and others. And also with increased anxiety, insomnia, headache, neuroinfections.
Adaptol- This drug belongs to the group of anxiolytic agents. This drug has a tranquilizing effect. During the reception, it quickly relieves the feeling of fear, tension, fatigue, stress.
Persen. This remedy has an antispasmodic and sedative effect. It contains herbal ingredients that help relieve tension, feelings of anxiety and irritation. It can be taken during insomnia, because the drug facilitates the process of falling asleep and does not cause drowsiness.
Tenoten- This is a drug that belongs to the group of tranquilizers. Quickly relieves anxiety, stress, emotional tension, helps relieve headaches and eliminates sleep problems.
Novopassit- This is a sedative-type sedative, which consists of plant components. The medicine has an effect on the nervous system, relieves nervous tension, fatigue, stress. It also helps with headaches, sleep disorders.
Phenazepam is a highly active tranquilizer. The drug has an anxiolytic, anticonvulsant, hypnotic and central muscle relaxant effect on the body. It is used during psychosis, sleep disorders, neurotic and psychopathic conditions.
Phenibut- it's a nootropic medicine, which refers to tranquilizers. Improves brain activity, increases blood circulation. During the reception, the working capacity of the body increases, mental activity, memory improves, stress, neurosis, tension disappear.
Grandaxin- the drug belongs to the tranquilizers, which belong to the group of benzodiazepines. Quickly relieves tension, fatigue, excitability, helps with headaches and insomnia. It is also taken in premenstrual syndrome, with myopathy, myasthenia gravis, neuroses, with alcohol withdrawal syndrome, and so on.
Fenzitat It is a tranquilizer that belongs to the group of benzodiazepine derivatives. It is used for neurosis, severe fatigue, emotional stress, vegetative disorders, sleep disorders.
Mebicar- a drug that belongs to tranquilizers for daytime use. This drug reduces anxiety, tension, fatigue, and also has a mild sedative effect.

Before using analogues, consult your doctor.

What is better Afobazol or Tenoten?

What is better Tenoten or Afobazol? It depends on each specific situation and individual patient. No specialist in the general case will be able to give an unambiguous answer. The undoubted advantage of Tenoten is the presence of the drug in a children's dosage. Tenoten can be used for some organic lesions of the central nervous system, including dyscirculation and trauma. Afobazol is not effective in these cases.

Tenoten, like any homeopathic remedy, begins to act gradually, a lasting effect occurs after a monthly course and the duration of treatment with this medicine is needed for a long time, preferably about 2 months. The maximum period of its reception is six months. It is not used for the treatment of alcohol withdrawal.

After taking Afobazole, the action comes faster, you can treat a hangover. But it does not have a neuroprotective effect, and is not used after stroke. Therefore, it is impossible to say unambiguously Tenoten or Afobazol which is better without seeing the picture of the disease.

Storage conditions and shelf life

The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C. Shelf life - 3 years.