Bromhexine 8 Berlin what drugs. Medicinal reference book geotar

Few facts about the product:

Instructions for use

Online pharmacy price website: from 120

Description of the drug

Bromhexine 8 Berlin Chemie (Bromhexine 8 Berlin Chemie) is a remedy, its functionality is aimed at helping patients who have an acute inflammatory process and a chronic course of bronchial diseases. It is also prescribed in the presence of a problem with sputum production in the lungs. For the mucolytic Bromhexine 8 Berlin Chemie, the instructions for use indicate the need for a dosage selection based on the patient's age. Bromhexin 1 Berlin Chemie received mostly positive reviews, which prove the high efficacy of the drug. For Bromhexin 1 Berlin Chemie, the price is from 122 rubles, while the online pharmacy offers the opportunity to order via the Internet.

Release form, composition, packaging

The release form is dragees, each of which is made on the basis of the main substance bromhexine, and in the amount of 8 mg. Additional ingredients are lactose monohydrate, starch, gelatin and silicon dioxide. Each tablet is coated with sucrose, talc, calcium and magnesium carbonate, glucose syrup, titanium dioxide, macrogol and povidone. Bromhexine 1 Berlin Chemie is offered to buy in packs of 20, 25, 40 and 50 pieces, each pack contains several blisters with yellow biconvex dragees with a white core.

pharmachologic effect

Bromhexine 8 Berlin Chemie is an expectorant that has a secretolytic and secretomotor effect. When used, depolymerization of mucoprotein and mucopolysaccharide molecules occurs, due to which there is a mucolytic effect. There is an effect on the production of endogenous surfactant, due to which it is possible to obtain a stable state of alveolar cells during respiration, and they are protected from the influence of negative factors. The drug of antitussive nature affects the increase in rheological parameters of bronchopulmonary secretions. This is due to the process that sputum is much easier and faster to be removed from respiratory tract... The substance is absorbed almost completely, and the connection with plasma proteins is 99 percent. The distribution amount is 7 l / kg. Penetrates into breast milk, and the half-life is from 1 to 16 hours. It is eliminated from the body in the urine in the form of metabolites.

Indications

Medicinal substance can have an antitussive effect, and therefore it is prescribed for patients who have a severe or chronic form of the course of bronchopulmonary diseases, which are supplemented by the production of viscous sputum, which happens to be associated with bronchial asthma, pneumonia, tracheobronchitis, obstructive bronchitis, emphysema, tuberculosis or pneumoconiosis.

Dosage

Bromhexine 1 Berlin Chemie Dragee is used for internal administration, prescribing is required after meals, swallowing whole. After use, you will need to drink the required amount of liquid, preferably plain water. Adults and children over 14 years of age are prescribed 24-48 mg, which is 1-2 capsules three times a day. Children aged 6-14 years and persons weighing less than 50 kg will need to use 24 mg per day, that is, one capsule three times a day. If you have problems with the functioning of the liver or kidneys, you will need to increase the intervals of use, or reduce the portion. To select the appropriate dosage, you will need to visit a specialist consultation. The medicine is used for 4-5 days, in case of need for long-term therapy, you will need to visit a doctor, who will indicate the duration of individual use.

Side effects

Bromhexine 8 Berlin Chemie is able to be tolerated normally, but in some situations, patients show certain negative signs: nausea and vomiting; exacerbation of gastric or duodenal ulcers; allergies, manifested by nasal congestion, rash and swelling; shortness of breath; a rise in temperature and chills; headache; increased activity of liver enzymes; Patients noticing the appearance of a negative effect will need to urgently stop the use and notify the doctor about it.

Contraindications

Increased sensitivity to the components of the mixture; lactose intolerance, lactase deficiency, glucose-galactose malabsorption; stomach ulcer or duodenum; first trimester of pregnancy; less than six years of age. If symptoms are present, Bromhexin 8 Berlin Chemie will need to be replaced with an analogue. The medicine is used with caution if the patient has certain symptoms: hepatic and renal failure; problems in the work of the bronchi, due to an increased increased production of secretions; a history of bleeding in the stomach.

Application for children

Bromhexine 8 Berlin Chemie can be prescribed for children only from the age of six; before that, use is not recommended.

special instructions

In case of problems with the work of the bronchi or increased secretion of sputum, Bromhexin 8 Berlin Chemie will need to be used with increased caution, due to the appearance of the likelihood of retaining the secreted mucus in the respiratory organs. The process will need to be accompanied by the use of an increased volume of fluid, due to which the secretolytic effect of the substance is performed. Severely ill renal failure it will be necessary to take into account the risks of accumulation of metabolites obtained in the liver. In children, during treatment, massage will be required. chest to facilitate the secretion of phlegm.

Overdose

There are no dangerous signs in case of a significant excess of the dose of the medication Bromhexine 8 Berlin Chemie.

Drug interactions

The substance Bromhexin 8 Berlin Chemie cannot be used in conjunction with medications that are responsible for eliminating cough, because this causes difficulties in the disposal of liquid sputum.

Storage conditions and periods

Use no longer than 5 years from the moment the packaging was released; the product should be in a place sheltered from sunlight at temperatures up to 25 degrees.

Bromhexine 8 Berlin-Chemie

International non-proprietary name

Bromhexine

Dosage form

Film-coated tablets, 8 mg

Compound

One coated tablet contains:

active substance - bromhexine hydrochloride 8 mg,

Excipients: corn starch, lactose monohydrate, magnesium stearate, gelatin, anhydrous colloidal silicon dioxide

shell composition: sucrose, calcium carbonate, light magnesium carbonate, talc, macrogol 6000, liquid glucose (in terms of dry matter), titanium dioxide (E 171), povidone K25, carnauba wax, quinoline yellow (E 104).

Description

Tablets with a slightly biconvex surface, covered with a yellow to greenish-yellow membrane, with an almost white core.

Pharmacotherapeutic group

Expectorant drugs. Mucolytics. Bromhexine.

ATX code R05CB02

Pharmacological properties

Pharmacokinetics

When taken orally, bromhexine is absorbed almost completely; its half-life is approx. 0.4 hours Cmax when taken orally is 1 hour. The effect of the first passage through the liver is about 80%. Biologically active substances are formed during the elimination process. Plasma protein binding is 99%.

The decrease in plasma concentration is a multiphase process. The half-life after which the action stops is about an hour. In addition, the final elimination half-life is approximately 16 hours. This is caused by the redistribution of small amounts of bromhexine in the tissues. The volume of distribution is approximately 7 liters per kg of body weight. Bromhexine is not accumulated in the body.

Bromhexine crosses the placental barrier, and also enters the cerebrospinal fluid and mother's milk.

Excretion is mainly through the kidneys, since metabolites are formed in the liver. Due to the high degree of binding of bromhexine to proteins and its significant volume of distribution, as well as due to its slow redistribution from tissues into the blood, elimination of any significant part of the drug through dialysis or forced diuresis is unlikely.

At serious illnesses the liver, a decrease in the clearance of the starting substance can be expected. In severe renal failure, the elimination half-life of bromhexine may be prolonged. Under physiological conditions in the stomach, nitrosation of bromhexine is possible.

Pharmacodynamics

Bromhexine is a synthetic derivative of the plant active substance vazicin. It has a secretolytic effect and promotes the evacuation of secretions from the bronchi. Studies have shown that this drug increases the proportion of the serous component in bronchial secretions. This facilitates the transport of sputum by reducing its viscosity and enhancing the work of the ciliary epithelium.

Against the background of the use of bromhexine, there is an increase in the concentration of antibiotics amoxicillin, erythromycin and oxytetracycline in sputum and bronchial secretions. The clinical significance of this effect has not been clarified.

Indications for use

Secretolytic therapy for acute and chronic diseases bronchi and lungs, accompanied by difficult to separate sputum

Method of administration and dosage

Adults take 1-2 tablets of Bromhexine 8 Berlin-Chemie 3 times a day (which corresponds to 24-48 mg of bromhexine hydrochloride per day).

Patients weighing less than 50 kg take 1 tablet of Bromhexine 8 Berlin-Chemie 3 times a day.

In severe disorders of liver or kidney function, it is recommended to reduce the dosage.

The tablets are taken after meals, without chewing, with plenty of liquid. The secretolytic effect of the drug is supported by fluid intake.

The duration of treatment is determined individually in accordance with the indications and the course of the disease. Bromhexine 8 Berlin Chemie should not be taken for more than 4-5 days without talking to your doctor.

Side effects

Sometimes (≥ 1/1000 to< 1/100)

Increased body temperature

Hypersensitivity reactions ( skin rash, angioedema, respiratory distress, pruritus, urticaria)

Nausea, abdominal pain, vomiting, diarrhea

Rarely (< 1/10000)

Anaphylactic reactions, including anaphylactic shock

Development of severe skin reactions such as Stevens-Johnson syndrome and Lyell's syndrome

In case of hypersensitivity reactions, anaphylactic reactions or any unusual changes in the skin and mucous membranes, stop taking Bromhexine 8 Berlin-Chemie immediately and consult a doctor.

Contraindications

Known hypersensitivity to bromhexine or one of the other components of the drug

Hereditary intolerance to galactose or fructose, glucose-galactose malabsorption syndrome, hereditary sucrase-isomaltase deficiency

Lactation period

Children under 18 years of age

Drug interactions

When using Bromhexine 8 Berlin-Chemie in combination with antitussive drugs, a dangerous accumulation of secretions is possible due to suppression of the cough reflex - therefore, when prescribing such a combination of drugs, a particularly careful examination is necessary.

With the simultaneous use of drugs that cause irritation symptoms gastrointestinal tract, it is possible to increase the irritating effect on the mucous membranes of the gastrointestinal tract.

special instructions

Skin reactions

As a result of the use of bromhegsin in extremely rare cases severe skin reactions have occurred, such as Stevens-Johnson syndrome and Lyell's syndrome. If you develop any unusual changes on the skin and mucous membranes, stop taking Bromhexine 8 Berlin-Chemie immediately and consult your doctor.

Stomach and duodenal ulcer

You should not use Bromhexine 8 Berlin-Chemie if you have (or have suffered in the past) a stomach or duodenal ulcer, since bromhexine can affect the barrier function of the gastrointestinal mucosa.

Lungs and airways

Due to the possible accumulation of secretions, when using Bromhexine 8 Berlin-Chemie in patients with impaired bronchial motility and increased mucus secretion (for example, with this rare disease, as primary ciliary dyskinesia [ciliary dyskinesia]) care must be taken.

Liver and kidney disorders

If liver function is impaired or if kidney disease special care must be taken (bromhexine should be taken at a lower dose or at longer intervals).

In severe renal failure, accumulation of bromhexine metabolites formed in the liver is likely.

Lactose, glucose, sucrose

This product contains lactose, glucose and sucrose. In this regard, it is contraindicated in patients with hereditary diseases such as fructose intolerance, glucose-galactose malabsorption syndrome or patients with a lack of sucrase-isomaltase in the body.

Pregnancy

Until now, there is no experience of using bromhexine during pregnancy; therefore, the use of Bromhexine 8 Berlin-Chemie by pregnant women is allowed only after a thorough assessment by the doctor of the risks and benefits; use in the first trimester of pregnancy is not recommended.

Features of the effect of the drug on the ability to manage vehicle or potentially dangerous mechanisms

Unknown

Overdose

Symptoms: cases of overdose in humans, which are dangerous, are still unknown.

There are no data on the chronic toxic effect of the drug in humans.

Treatment: after a significant overdose, blood circulation control is shown, if necessary, symptomatic treatment... Due to the low toxicity of bromhexine, there is no need for more invasive measures to reduce absorption or accelerate its excretion from the body. In addition, due to pharmacokinetic features (large volume of distribution, slow redistribution processes and significant binding to proteins), dialysis and forced diuresis do not significantly affect the excretion of the substance from the body.

Release form and packaging

25 tablets are placed in a blister strip of rigid transparent polyvinyl chloride film and hard aluminum foil.

1 or 2 contour packs with instructions for medical use in the state and Russian languages are put into a cardboard pack.

Storage conditions

Store at a temperature not exceeding 25 ° C.

Keep out of the reach of children!

Storage period

After the expiration date, the drug cannot be used!

Conditions of dispensing from pharmacies

Without recipe

Manufacturer

The address of the organization that accepts claims from consumers on the territory of the Republic of Kazakhstan regarding the quality of products (goods):

Representative office of JSC "Berlin-Chemi AG" in the Republic of Kazakhstan

Tel .: +7 727 2446183, 2446184, 2446185

Fax: +7 727 2446180

E-mail address: [email protected]

Mucolytic agent with expectorant action.
Preparation: BROMHEXIN 8 BERLIN-CHEMI
The active substance of the drug: bromhexine
ATX encoding: R05CB02
KFG: Mucolytic and expectorant drug
Registration number: P No. 015546/01
Date of registration: 12.04.04
Owner reg. ID: BERLIN-CHEMIE AG / MENARINI GROUP (Germany)

Release form Bromhexin 8 berlin-hemi, drug packaging and composition.

Dragee slightly convex on both sides, from yellow to greenish-yellow; the core of the dragee is almost white.

1 tablet
bromhexine hydrochloride
8 mg

Excipients: lactose monohydrate, corn starch, gelatin, highly dispersed silicon dioxide, magnesium stearate, sucrose, calcium carbonate, basic magnesium carbonate, talc, dyes (E104 and E171), macrogol 6000, povidone, dextrose syrup, carnauba wax.

20 pcs. - blisters (1) - cardboard packs.
20 pcs. - blisters (2) - cardboard packs.
25 pcs. - blisters (1) - cardboard packs.
25 pcs. - blisters (2) - cardboard packs.

DESCRIPTION OF THE ACTIVE SUBSTANCE.
All the information given is presented only for familiarization with the drug, you should consult your doctor about the possibility of using it.

PHARMACHOLOGIC EFFECT
Mucolytic agent with expectorant action. Reduces the viscosity of bronchial secretions by depolarizing the acidic polysaccharides contained in it and stimulating the secretory cells of the bronchial mucosa, which produce secretions containing neutral polysaccharides. It is believed that bromhexine promotes the formation of a surfactant.

Pharmacokinetics of the drug.

Bromhexine is rapidly absorbed from the gastrointestinal tract and undergoes intensive metabolism during the "first pass" through the liver. Bioavailability is about 20%. In healthy patients, Cmax in plasma is determined after 1 hour.

It is widely distributed in body tissues. About 85-90% is excreted in the urine mainly in the form of metabolites. The metabolite of bromhexine is ambroxol.

Plasma protein binding of bromhexine is high. T1 / 2 in the terminal phase is about 12 hours.

Bromhexine penetrates the BBB. In small quantities, it crosses the placental barrier.

Only small amounts are excreted in the urine with a T1 / 2 6.5 h.

The clearance of bromhexine or its metabolites may decrease in patients with severe hepatic and renal impairment.

Indications for use:

Diseases of the respiratory tract, accompanied by the formation of a viscous secretion that is difficult to separate: tracheobronchitis, chronic bronchitis with a broncho-obstructive component, bronchial asthma, cystic fibrosis, chronic pneumonia.

Dosage and method of administration of the drug.

In the form of inhalation for adults - 8 mg each, for children over 10 years old - 4 mg each, at the age of 6-10 years - 2 mg each. At the age of 6 years - used in doses up to 2 mg. Inhalations are carried out 2 times / day.

The therapeutic effect may appear on the 4th-6th day of treatment.

Side effects of Bromhexine 8 Berlin-Chemie:

From the side digestive system: dyspeptic phenomena, transient increase in the activity of hepatic transaminases in the blood serum.

From the side of the central nervous system: headache, dizziness.

Dermatological reactions: increased sweating, skin rash.

From the side respiratory system: cough, bronchospasm.

Contraindications to the drug:

Hypersensitivity to bromhexine.

Application during pregnancy and lactation.

During pregnancy and lactation, bromhexine is used in cases where the intended benefit to the mother outweighs the potential risk to the fetus or child.

Special instructions for the use of Bromhexin 8 berlin-hemi.

With gastric ulcer, as well as with indications of a history of gastric bleeding, bromhexine should be used under the supervision of a physician.

Use with caution in patients with bronchial asthma.

Bromhexine is not used simultaneously with medicines containing codeine, because this makes it difficult to cough up the liquefied sputum.

Used as part of combination drugs vegetable origin with essential oils(including with eucalyptus oil, anise oil, peppermint oil, menthol).

DRUG INTERACTIONS
Bromhexine is incompatible with alkaline solutions.

Instructions for use

Active ingredients

Release form

Compound

1 tablet: Bromhexine hydrochloride 8 mg. Excipients: lactose monohydrate - 34.4 mg, corn starch - 14.6 mg, gelatin - 1.8 mg, colloidal silicon dioxide - 0.6 mg, magnesium stearate - 0.6 mg Shell composition: sucrose - 27.704 mg, calcium carbonate - 4.326 mg, magnesium carbonate - 1.507 mg, talc - 1.507 mg, macrogol 6000 - 1.75 mg, povidone K25 - 0.243 mg, glucose syrup - 1.639 mg, carnauba wax - 0.012 mg, titanium dioxide (E171) - 1.166 mg, quinoline yellow (E104) - 0.146 mg.

Pharmacological effect

Mucolytic agent with expectorant action. Reduces the viscosity of bronchial secretions by depolarizing the acidic polysaccharides contained in it and stimulating the secretory cells of the bronchial mucosa, which produce secretions containing neutral polysaccharides. It is believed that bromhexine promotes the formation of a surfactant.

Pharmacokinetics

Bromhexine is rapidly absorbed from the gastrointestinal tract and undergoes intensive metabolism during the first passage through the liver. Bioavailability is about 20%. In healthy patients, Cmax in plasma is determined after 1 hour. It is widely distributed in the tissues of the body. About 85-90% is excreted in the urine mainly in the form of metabolites. The metabolite of bromhexine is ambroxol. The binding of bromhexine to plasma proteins is high. T1 / 2 in the terminal phase is about 12 hours. Bromhexine penetrates the BBB. In small amounts, it crosses the placental barrier. Only small amounts are excreted in the urine with T1 / 2 6.5 hours. The clearance of bromhexine or its metabolites may decrease in patients with severely impaired liver and kidney function.

Indications

Diseases of the respiratory tract, accompanied by the formation of a viscous secretion difficult to separate: tracheobronchitis, chronic bronchitis with a broncho-obstructive component, bronchial asthma, cystic fibrosis, chronic pneumonia.

Contraindications

Hypersensitivity to bromhexine.

Precautionary measures

Application during pregnancy and lactation

During pregnancy and lactation, bromhexine is used in cases where the intended benefit to the mother outweighs the potential risk to the fetus or child.

Method of administration and dosage

Inside for adults and children over 10 years old - 8 mg 3-4 times / day. Children under the age of 2 years - 2 mg 3 times / day; at the age of 2 to 6 years - 4 mg 3 times / day; at the age of 6 to 10 years - 6-8 mg 3 times / day. If necessary, the dose can be increased for adults up to 16 mg 4 times / day, for children - up to 16 mg 2 times / day; in the form of inhalations for adults - 8 mg, for children over 10 years old - 4 mg, at the age of 6-10 years - 2 mg. At the age of 6 years - used in doses up to 2 mg. Inhalations are carried out 2 times / day. The therapeutic effect may appear on the 4-6th day of treatment. Parenteral administration is recommended for treatment in severe cases, as well as in the postoperative period to prevent the accumulation of thick sputum in the bronchi. Enter 2 mg s / c, i / m or i / v 2-3 times / day slowly for 2-3 minutes.

Side effects

From the digestive system: dyspeptic phenomena, a transient increase in the activity of hepatic transaminases in the blood serum. From the central nervous system: headache, dizziness. Dermatological reactions: increased sweating, skin rash. From the respiratory system: cough, bronchospasm.

Overdose

Symptoms: headache, nausea, vomiting. Treatment: symptomatic. There is no specific antidote.

Interaction with other drugs

Bromhexine is incompatible with alkaline solutions.

special instructions

In case of gastric ulcer, as well as if there is a history of gastric bleeding, bromhexine should be used under the supervision of a physician. Use with caution in patients with bronchial asthma. This makes it difficult to cough up liquefied sputum. It is used as part of combined herbal preparations with essential oils (including eucalyptus oil, anise oil, peppermint oil, menthol).

Bromhexine 8 Berlin-Chemie is an expectorant, mucolytic. It is used for diseases of the respiratory tract, accompanied by increased secretion of viscous sputum (bronchial asthma, pneumonia, diffuse inflammation, covering the lower airways - trachea and bronchi, spasmodic bronchitis, irreversible expansion of the bronchus region, pulmonary emphysema, tuberculosis, development of fibrotic process in the lungs due to prolonged inhalation of industrial dust). It dilutes phlegm and facilitates its excretion from the lungs, ensures effective removal of bronchial secretions from the respiratory tract, and has a weak antitussive effect. Improves the rheological properties of sputum, activates the ciliated epithelium, increases the volume of pathological secretion of the trachea and bronchi, which is secreted during expectoration, improving its discharge. Stimulates the production of surfactants that line the pulmonary alveoli from the inside and ensure their stability during breathing - pulmonary surfactant. The effect of Bromhexine 8 Berlin-Chemie becomes noticeable on days 2-5 of the drug course. At oral administration quickly (within half an hour) and is almost completely absorbed from the gastrointestinal tract. About 80% of the introduced substance enters the bloodstream unchanged. It binds almost completely to plasma proteins. In the liver, it undergoes metabolic transformations with the formation of the active metabolite ambroxol. The half-life of the drug is relatively long due to delayed reverse diffusion from tissues and is 15 hours. In chronic kidney disease, in which there is a gradual death of the renal tissue, the excretion of metabolites from the body is impaired. With prolonged use, the drug can accumulate in the body. Bromhexine 8 Berlin-Chemie is not used for individual drug intolerance, stomach and duodenal ulcers at the time of exacerbation, during pregnancy and during breastfeeding(the drug passes into breast milk).

In pediatric practice, Bromhexin 8 Berlin-Chemie is used from the age of 6. The drug is prescribed with caution in case of insufficiency of liver and / or kidney function, impaired motor function of the bronchi, accompanied by excessive accumulation of bronchial secretions, with frequent gastric bleeding in the history of the disease. The optimal time for taking the drug is after eating. Frequency rate of application - three times a day. Single dose - 1-2 pills (depending on age and clinical situation). In case of insufficient renal function, a single dose is reduced or the time intervals between doses are increased. Determining the tactics of treatment in such patients is the exclusive prerogative of the doctor. The duration of the drug course is set individually and depends on the indications and the nature of the course of the disease. If you need to use the drug for more than 4-5 days, you should consult your doctor. Bromhexine 8 Berlin-Chemie has a favorable safety profile and is generally well tolerated by patients. Side effects(nausea, vomiting, epigastric pain, exacerbation of stomach and duodenal ulcers, skin rash, runny nose, swelling, rapid and labored breathing, hyperthermia) are rare. Cases of drug overdose are not described in the medical literature. Theoretically, an overdose can manifest itself as symptoms of intoxication (nausea, vomiting, diarrhea). Treatment is symptomatic. Bromhexine 8 Berlin-Chemie is not used in combination with centrally acting antitussive drugs (for example, codeine-containing drugs) that inhibit the cough reflex, because this makes it difficult to remove liquefied bronchial secretions. The drug promotes penetration antibacterial drugs into sputum in the first 4-5 days of the drug course. During pharmacotherapy, it is necessary to increase fluid intake, because this measure will help increase the effectiveness of the drug in thinning sputum.

Pharmacology

Pharmacokinetics

It is widely distributed in body tissues. About 85-90% is excreted in the urine mainly in the form of metabolites. The metabolite of bromhexine is ambroxol.

Plasma protein binding of bromhexine is high. T 1/2 in the terminal phase is about 12 hours.

Bromhexine penetrates the BBB. In small quantities, it crosses the placental barrier.

Only small amounts are excreted in the urine with a T 1/2 of 6.5 h.

The clearance of bromhexine or its metabolites may decrease in patients with severe hepatic and renal impairment.

Release form

Dragee from yellow to greenish-yellow in color, biconvex, with an almost white core.

Excipients: lactose monohydrate - 34.4 mg, corn starch - 14.6 mg, gelatin - 1.8 mg, colloidal silicon dioxide - 0.6 mg, magnesium stearate - 0.6 mg.

Shell composition: sucrose - 27.704 mg, calcium carbonate - 4.326 mg, magnesium carbonate - 1.507 mg, talc - 1.507 mg, macrogol 6000 - 1.75 mg, povidone K25 - 0.243 mg, glucose syrup - 1.639 mg, carnauba wax - 0.012 mg, titanium dioxide (E171) - 1.166 mg, quinoline yellow (E104) - 0.146 mg.

25 pcs. - blisters (1) - cardboard packs.

Dosage

The therapeutic effect may appear on the 4th-6th day of treatment.

Interaction

Bromhexine is incompatible with alkaline solutions.

Hypersensitivity to bromhexine.

Application features

Application during pregnancy and lactation

During pregnancy and lactation, bromhexine is used in cases where the intended benefit to the mother outweighs the potential risk to the fetus or child.

special instructions

With gastric ulcer, as well as with indications of a history of gastric bleeding, bromhexine should be used under the supervision of a physician.

Use with caution in patients with bronchial asthma.

Bromhexine is not used simultaneously with drugs containing codeine, because this makes it difficult to cough up the liquefied sputum.

It is used as part of combined herbal preparations with essential oils (including with eucalyptus oil, anise oil, peppermint oil, menthol).