Vikasol solution. Vikasol tablets and ampoules - instructions for use, analogues, prices and reviews

Recipe (international)

Rp.: Sol. Vicasoli 1% pro inject I ml
D.t.d. #4
S. In / m no 1ml in tech. 4d.

Recipe (Russia)

Rp.: Sol. Menadioni natrii bisulfitis 1% pro inject.1 ml

S. In / m no 1ml

Rep.: Tab. Menadioni sodium bisulfitis 15 mg

S. 1 tablet 3 times a day

Prescription form - 107-1 / y

Active substance

Menadione sodium bisulfite (Menadione sodium bisulfite)

pharmachologic effect

Antihemorrhagic agent. It is a synthetic analogue of vitamin K. It is a cofactor in the synthesis of prothrombin and other blood coagulation factors (VII, IX, X) in the liver, and contributes to the normalization of the blood coagulation process.

Mode of application

For adults:

The drug is administered intramuscularly.

For adults, a single dose is 10-15 mg, the maximum single dose is 30 mg, the maximum daily dose is 60 mg.

The daily dose can be divided into 2-3 doses. In surgical interventions with possible severe parenchymal bleeding, it is prescribed for 2-3 days before surgery.

In patients with hepatic insufficiency, the drug should be administered with caution.

For children:

In pediatrics:

newborns - 0.4 mg / kg / day;

up to 1 year - 2-5 mg / day;

1-2 years - 6 mg / day;

3-4 years - 8 mg / day;

5-9 years - 10 mg / day;

10-14 years - 15 mg / day.

From the age of 15, the drug is prescribed in the same way as for adult patients. The duration of treatment is 3-4 days, after a four-day break, again 3-4 days.

Indications

Hemorrhagic syndrome associated with hypoprothrombinemia
- hypovitaminosis K (including with obstructive jaundice, hepatitis, cirrhosis of the liver, prolonged diarrhea)
- hemorrhagic disease of the newborn
- bleeding after injuries, injuries and surgical interventions
- in gynecology as part of complex treatment dysfunctional uterine bleeding not associated with organic pathology, with menorrhagia. As a specific antagonist for bleeding associated with indirect anticoagulants. III trimester of pregnancy (to prevent bleeding in newborns).

Contraindications

Increased blood clotting
- thromboembolism
- hypersensitivity to menadione.

Side effects

Allergic reactions:
skin rash, itching, erythema, urticaria, bronchospasm.
- From the blood coagulation system:
hemolytic disease of the newborn.

Release form

Tab. 15 mg: 20 pcs.
Tablets 1 tab.
20 pcs. - cellular contour packings (1) - packs of cardboard.
The drug is dispensed by prescription tab. 15 mg: 30 pcs.
Tablets 1 tab.
menadione sodium bisulfite 15 mg
30 pcs. - jars of dark glass (1) - packs of cardboard.

ATTENTION!

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Name:

Vikasol (Vikasolum)

Pharmacological
action:

Antihemorrhagic agent. It is a synthetic analogue of vitamin K.
It is a cofactor in the synthesis of prothrombin and other blood coagulation factors (VII, IX, X) in the liver, contributes to the normalization of the blood coagulation process.

Pharmacokinetics
After oral administration, it is absorbed from the gastrointestinal tract. Plasma protein binding is reversible.
Accumulates mainly in the liver, spleen, myocardium. It is converted into vitamin K2 in the body.
The process of transformation occurs most intensively in the myocardium, skeletal muscles, somewhat weaker - in the kidneys.
Metabolites of vitamin K (monosulfate, phosphate and digducuronide-2-methyl-1.4-naphthoquinone) are excreted in the urine - up to 70%.

Indications for
application:

Jaundice due to a delay in the flow of bile into the intestines, acute hepatitis (inflammation of the liver tissue);
- parenchymal (from internal organs) and capillary bleeding (used in preparation for and after surgical operations);
- bleeding with ulcers of the stomach and duodenum;
- radiation sickness;
- thrombopenic purpura (multiple hemorrhages under the skin and / or mucous membranes due to a decrease in the level of platelets in the blood);
- persistent hemorrhoidal (from the dilated veins of the rectum) and nosebleeds;
- the last months of pregnancy (to prevent bleeding in newborns);
- hemorrhagic disease (increased bleeding) in newborns;
- prolonged uterine juvenile and premenopausal bleeding (dysfunctional uterine bleeding before puberty and in the premenopausal period);
- bleeding in pulmonary tuberculosis, septic diseases (diseases associated with the presence of microbes in the blood), severe hypoprothrombinemia (a decrease in the content of prothrombin in the blood - a blood clotting factor), when using anticoagulants (drugs that inhibit blood clotting) - antagonists (drugs with the opposite effect ) vitamin K: phenylin, neodicoumarin, etc.

With hemophilia(a hereditary disease accompanied by reduced blood clotting) and Werlhof's disease(multiple hemorrhages under the skin and mucous membranes due to a decrease in the level of platelets in the blood) vikasol is ineffective.

Mode of application:

Inside adults 0.015-0.3 g per day; intramuscularly 0.01-0.015 g.
Higher doses for adults inside: single - 0.03 g, daily - 0.06 g; intramuscularly: single - 0.015 g, daily - 0.03 g.
Children under 1 year old prescribe 0.002-0.005 g, up to 3 years - 0.006 g, 3-4 years - 0.008 g, 5-9 years - 0.01 g, 10-14 years - 0.015 g per day in 2-3 doses 3-4 days in a row ; after a break of 4 days, the course of treatment is repeated.
Before the operation, the drug is prescribed for 2-3 days.
Women in labor give a daily dose immediately after arrival at the maternity hospital, and then, if childbirth does not occur, after 12 hours and after 24 hours. The dose for newborns is not higher than 0.004 g.

Side effects:

In case of an overdose in rare cases hypervitaminosis K occurs, manifested by hyperprothrombinemia and hyperthrombinemia (increased levels of prothrombin and thrombin in the blood - blood coagulation factors), hyperbilirubinemia (increased levels of bilirubin pigment in the blood); in isolated cases, children develop toxicosis (poisoning), manifested by convulsions.

Contraindications:

Hypersensitivity to the components of Vikasol;
- increased clotting blood, thromboembolism;
- hemolytic disease of the newborn.
Carefully: 6-phosphate dehydrogenase deficiency, liver failure, pregnancy.

Interaction
other medicinal
by other means:

Reduces or blocks the anticoagulant action of neodicoumarin and phenylin.
Does not affect the anticoagulant activity of heparin. Simultaneous administration with broad-spectrum antibiotics, quinidine, quinine, salicylates in high doses, antibacterial sulfonamides requires an increase in the dose of vitamin K

Pregnancy:

It is used during pregnancy according to indications.

Overdose:

Symptoms: hypervitaminosis K, manifested by hyperprothrombinemia and hyperthrombinemia, hyperbilirubinemia, jaundice, increased activity of liver enzymes; Abdominal pain, constipation or diarrhea, general agitation, agitation, and skin rash have been noted. In isolated cases, children develop toxicosis, manifested by convulsions.
Treatment: cancel the drug. Under the control of indicators of the coagulation system, anticoagulants are prescribed. Therapy is symptomatic.

Instructions for use:

Vikasol belongs to the group of vitamins obtained synthetically. Vitamin K analog.

pharmachologic effect

A water-soluble analogue of natural vitamin K obtained in the laboratory. Takes part in the formation of prothrombin. Normalizes blood coagulability. Vitamin K deficiency leads to increased bleeding.

Release form

Vikasol is produced in powder, in tablets of 0.015 g and in ampoules of 1 ml with a 1% solution.

Indications for Vikasol's use

The use of Vikasol is advisable in the following cases:

Jaundice, which develops due to untimely entry of bile into the intestine;

Capillary and parenchymal bleeding;

Bleeding that occurs with peptic ulcer of the stomach and duodenum;

thrombocytopenic purpura;

Radiation sickness;

Persistent nose and hemorrhoidal bleeding.

According to the instructions, Vikasol is prescribed to pregnant women in the last trimester to prevent bleeding in newborns.

It is possible to use Vikasol in newborns with hemorrhagic disease (increased bleeding).

Vikasol injections and tablets are prescribed for juvenile uterine and dysfunctional uterine bleeding before puberty and in the premenopausal period.

The use of Vikasol is advisable in case of bleeding in tuberculosis, septic diseases, reduced clotting, the use of anticoagulants, vitamin K antagonists, phenylin, neodicoumarin and other drugs with a similar effect.

The appointment of a solution for injection and Vikasol tablets for hemophilia and Werlhof's disease does not bring the desired therapeutic effect.

Instructions for use Vikasol and doses

Vikasol tablets are taken orally. The solution for injection is prescribed intramuscularly. The average dose for adults: Vikasol tablets from 0.015 to 0.3 g per day; solution for injection from 0.01 to 0.015 g. The maximum allowable doses for adults: Vikasol tablets at a time, not more than 0.03 g, per day - not more than 0.06 g; intramuscularly in injections of not more than 0.015 g per injection and not more than 0.03 g per day.

It is possible to use Vikasol for children under one year old. In this case, the allowable daily dose is from 0.002 to 0.005 g. Children under three years of age can take Vikasol at a dose of 0.006 grams, at the age of 3 to 4 years - 0.008 g, at 5-9 years old, 0.01 g of Vikasol can be prescribed, from 10 to 14 years, 0.015 g each. The daily dose is divided into 2 or three doses, Vikasol is taken according to the instructions for three or four days in a row, then a four-day break is taken, and the course is repeated again.

The dose of Vikasol for newborns should not exceed 0.004 grams.

Women in labor are prescribed Vikasol in daily dose for adults at one time, if childbirth does not occur, then the use of Vikasol is advisable after 12 and 24 hours.

Side effects

The instructions for Vikasol indicate possible side effects. These include:

Hypervitaminosis of vitamin K, resulting in an increase in prothrombin and thrombin, bilirubin;

Toxicosis in children, which manifests itself in the form of seizures.

Contraindications to the use of Vikasol

Vikasol is contraindicated in patients with increased blood clotting and thromboembolism (blockage of blood vessels by blood clots).

Vikasol during menstruation

Vikasol during menstruation has the ability to reduce the amount of discharge, if they are abundant. But Vikasol during menstruation does not always bring the desired effect. Therefore, it is not recommended to take Vikasol during menstruation on your own, it is necessary to be examined by a gynecologist. It should be remembered that only a doctor can prescribe Vikasol.

Pharmacokinetics

After oral administration, it is absorbed from the gastrointestinal tract. Plasma protein binding is reversible. Accumulates mainly in the liver, spleen, myocardium. It is converted into vitamin K 2 in the body. The process of transformation occurs most intensively in the myocardium, skeletal muscles, somewhat weaker - in the kidneys.

Metabolites of vitamin K (monosulfate, phosphate and diglucuronide-2-methyl-1.4-naphthoquinone) are excreted in the urine - up to 70%.

Release form

1 ml - ampoules (5) - blister packs (2) - cardboard packs.

Dosage

Adults when taken orally - 15-30 mg / day, intramuscularly - 10-15 mg / day.

Children under the age of 1 year - 2-5 mg / day, up to 2 years - 6 mg / day, 3-4 years - 8 mg / day, 5-9 years - 10 mg / day, 10-14 years - 15 mg / day The frequency of admission is 2-3 times / day. The duration of treatment is set individually.

Maximum doses: for adults, when taken orally, a single dose is 30 mg, a daily dose is 60 mg; with i / m administration, a single dose - 15 mg, daily - 30 mg. For newborns - 4 mg / day.

Interaction

With simultaneous use with oral anticoagulants, a decrease in the anticoagulant effect is possible.

Side effects

Allergic reactions: skin rash, itching, erythema, urticaria, bronchospasm.

From the blood coagulation system: hemolytic disease of the newborn.

Indications

Hemorrhagic syndrome associated with hypoprothrombinemia; hypovitaminosis K (including with obstructive jaundice, hepatitis, cirrhosis of the liver, prolonged diarrhea); hemorrhagic disease of the newborn; bleeding after injuries, injuries and surgical interventions; in gynecology as part of the complex treatment of dysfunctional uterine bleeding not associated with organic pathology, with menorrhagia. As a specific antagonist for bleeding associated with indirect anticoagulants. III trimester of pregnancy (to prevent bleeding in newborns).

Contraindications

Increased blood clotting, thromboembolism, hypersensitivity to menadione.

Application features

Use during pregnancy and lactation

It is used during pregnancy according to indications.

Use in children

Application is possible according to the dosing regimen.

special instructions

In diseases leading to a violation of the outflow of bile, parenteral administration is recommended. With hemophilia and Werlhof's disease, menadione is ineffective.

Vikasol instruction

The instruction warns the patient about contraindications to taking the drug Vikasol (tablets and ampoules), their side effects, and also describes in detail the dosing regimen medicinal product. Here you can read about prices and reviews of Vikasol.

Form, composition, packaging

The drug is produced by the manufacturer in the form of tablets for oral administration and an injection solution for intramuscular injection.

The active substance of the drug is a synthetic analogue of vitamin K and menadione sodium bisulfite in the required proportions.

Pharmacology

The pharmacological properties of the drug are reduced to providing a hemostatic effect. An increase in blood clotting is promoted by vitamin K, a water-soluble analogue, which, by its action, has a beneficial effect on the process of synthesizing proconvertin and prothrombin.

The effectiveness of the drug manifests itself in the range from 8 to 24 hours after it was administered intramuscularly.

Vikasol indications for use

The drug is prescribed for the treatment of patients according to the following indications:

in preventive purposes and for the treatment of hypoprothrombinemia;
with obstructive jaundice;
in the presence of violations of intestinal absorption;
with celiac disease (celiac disease);
with violations of the functionality of the small intestine;
in case of malfunctions of the pancreatic gland;
with the formation of intestinal obstruction (resection);
with diarrhea of a protracted nature;
with dysentery;
Crohn's disease,
with ulcerative colitis;
for parenteral nutrition of newborns that receive a mixture of an unenriched type or those that are breastfed;
with hemorrhagic disease in infants for prevention and treatment.

Contraindications

Purpose medicinal product it is not recommended if the patient suffers from hypersensitivity, or if he has a thromboembolic or hypercoagulable state. Also, if a hemolytic disease is detected immediately after birth.

Vikasol instructions for use

Intramuscular injections. For an adult in a single dosage of ten or fifteen milligrams, in a daily dose of thirty milligrams.
Inside reception in tablets. For an adult patient, fifteen or thirty milligrams per day. Children aged ten to fourteen years, fifteen milligrams per day, five to nine years, 10 mg / day, three to four years, eight milligrams per day, up to two years of age, six milligrams per day, up to one year old from two up to five milligrams per day, immediately after birth, four milligrams per day.

The duration of therapy is usually up to four days. It is possible to repeat the treatment course with an interval of four days.

With a planned operation with a prognosis for severe parenchymal bleeding, the patient is prescribed the drug a few days before the operation.

Side effects

Allergy

In the form of the development of bronchospasm, hyperemia of the skin of the face, a rash on the skin, accompanied by itching.

circulatory system

In the form of hemolytic anemia, as well as possible development hemolysis in infants with congenital deficiency of glucose-6-phosphate dehydrogenase.

locally

Painful swelling at the injection sites, in the form of lesions skin(spots) when repeating the injection in the same place.

Miscellaneous

In the form of development of hyperbilirubinemia, jaundice. In rare cases, side effects were observed in the form of dizziness, variability in taste, a transient drop in blood pressure, tachycardia, and a weak pulse.

Drug Interactions

While taking Vikasol with other medicines, the following is noted:

indirect anticoagulants - their effectiveness is weakened;
antacids - reduce the absorption of the drug;
heparin - there is no decrease in its anticoagulant activity;
antibiotics - an increase in the dosage of vitamin (K) is required;
the use of Dactinomycin, Colestyramine, sucralfate, Colestipol, as well as mineral oils helps to reduce the absorption of vitamin (K), which prescribes to increase its dosage;
combination with hemolytic drugs increases the risk of side effects.

Additional instructions

When prescribing Vikasol, one should take into account its low effectiveness in case of detection of hemophilia in a patient.

If the patient has disorders in the process of bile outflow, the drug should be administered exclusively by injection.

Since by the third trimester of pregnancy the permeability of the placenta becomes very low, prescribing the drug during this period is simply ineffective.

Vikasol analogs

If it is necessary to replace the drug in treatment, you can use its analogues: Dicinon, Tranexam, Etamzilat, Takhacomb.

Vikasol price

The prices for the drug pleasantly surprise with their cheapness and range from 11 to 80 rubles, depending on its dosage form.

Vikasol reviews

In patient reviews, there is a significant variety of laudatory epithets addressed to the drug.

Hope: Timely taken Vikasol in the form of tablets saved me from the need to transfuse blood with a lot of blood loss ( uterine bleeding). Wonderful medicine.

Marina: I keep the drug in my home medicine cabinet for emergency situations. There were cases when she simply bled during heavy periods, and after taking one or two tablets, the process returned to normal. Rescue remedy.