Solpadeine tablets - instructions for use. Solpadein: instructions for use Solpadein instructions for use effervescent tablets side effects

Solpadeine belongs to the clinical and pharmacological group of analgesics-anaperetics. Analogues of this drug are medicines such as: Migrenol tablets, Extra, as well as Strimol plus and Paralen Extra.

Solpadeine fast is presented in the form of white soluble tablets, which contain 500 mg of paracetamol and 65 mg of caffeine. Auxiliary substances are: sorbitol, sodium salts, dimethicone, citric acid.

Pharmacological action of the drug

Solpadein fast is an analgesic-anaperetic in its own way pharmacological action, which has a combined composition in the form and caffeine. The drug has both antipyretic and analgesic effects.

In this case, penetrating into the human body, paracetamol has an active effect on the central nervous system blocking the synthesis of prostaglandins. Paracetamol does not have a negative effect on the gastrointestinal tract, and also does not take part in the water-salt metabolism, like most drugs.

Caffeine in the composition of Solpadeine fast affects the motor reactions of the human brain, significantly increasing the effect on the body of the main analgesic Paracetamol. At the same time, the feeling of weakness, fatigue completely disappears in a person, both physical and mental activity sharply increases.

Dosage of the drug

Before use, Solpadein fast effervescent tablets must be dissolved in 100 ml of water (this is approximately half a glass). An adult is prescribed about 1-2 tablets 4 times a day, observing the interval between doses of the medicine - at least 4 hours. At a time, you can take a maximum of 2 tablets of Solpadein, a day - a maximum of 8 tablets.

In no case is it recommended to take the drug Solpadein for more than 5 days in a row for the purpose of pain relief. Also, it is not recommended to take more than 3 days to reduce the temperature. All these conditions require a doctor's consultation, as well as the appointment of a particular drug.

drug overdose

In case of an overdose of the drug, that is, with a significant excess of the recommended dose of Solpadein for use, it is necessary to urgently seek an ambulance medical care. You need to do this even if you feel well.

The main symptoms of an overdose are the following conditions:

Vomit;
Nausea;
Strong ;
Pale face;
Weight loss, refusal to eat.

Approximately on the second day, a person begins to show all the signs of pathological liver damage. In very severe acute cases, liver failure and even coma can develop.

What should be done in case of an overdose of Solpadeine fast?

Overdose:

Rinse the stomach with warm water;
Drink plenty of water in small sips - about 2 liters;
Drink activated charcoal;
Contact an ambulance.

What medicines does Solpadein fast interact with?

If Solpadein Fast is used together with Warfarin medications, as well as all types of coumarins, this can lead to bleeding.

Solpadein fast significantly enhances MAO inhibitors.

barbiturates;
Phenytoin;
Rifampicin;
antidepressants;
Cimetidine;
Chloramphenicol;
caffeinated drinks;
Metoclopramide;
Domperidone;
Colestyramine.

The drug is prescribed very carefully during pregnancy and while breastfeeding.

Side effects of Solpadein Fast

After the use of Solpadein Fast, a negative reaction from the side is not excluded. internal organs person, for example:

Manifestation of allergies skin rash, severe itching, as well as Quincke's edema;
Work disruptions gastrointestinal tract- nausea, stomach pain;
The circulatory system is subject to such disorders as anemia, leukopenia, as well as agrunulocytosis, as well as methemoglobinemia;
Sleep disturbance in the form of insomnia;
Heart rhythm disturbances, tachycardia.

In most cases, Solpadein Fast tablets are well tolerated by humans, provided the recommended doses are in the instructions. If Solpadein Fast is used for a long period of time, then the likelihood of a negative hepatoxic effect on the body, as well as pancytopenia, sharply arises.

Indications for use Solpadein Fast effervescent

Strong headache;
Migraine;
Neuralgic diseases;
muscle pain;
Pain in rheumatism;
Severe pain during menstruation;
Sore throat;
Heat;
Flu;
Colds.

It is not recommended to take Solpadein Fast effervescent for violations of the liver, kidneys; with glaucoma; insomnia (since the drug contains caffeine), with epileptic seizures, as well as for children under 12 years of age. The negative effect of the drug Solpadein Fast can be when taking it with other medicines containing paracetamol.

If you started taking Solpadein Fast effervescent tablets, then try not to drink coffee or tea on this day, as this combination leads to sleep disturbance, cardiac arrhythmia, tachycardia.

When treating with solpadeine fast for a long time, it is necessary to take a blood test and check the condition of the body.

In order to avoid toxic poisoning with the active substances of solpadein fast effervescent, you need to completely refrain from drinking alcoholic beverages for some time.

If you have a diagnosis of atopic bronchial asthma, you may be at risk of an allergic reaction.

If you are on a salt-free diet, then consider the fact that one tablet of solpadeine fast contains about 427 mg of sodium salts.

Solpadein is combination drug with analgesic and antipyretic action. The active ingredients are paracetamol, caffeine, codeine phosphate hemihydrate.

The action of the drug consists of the actions of the components:

Non-narcotic analgesic Paracetamol has an analgesic and antipyretic effect, stops COX1 and COX2 mainly in the central nervous system, affecting the centers of thermoregulation and pain.
The alkaloid of the phenanthrene series Codeine has an antitussive effect of the central type (depresses the excitability of the cough center) and has an analgesic effect.
Caffeine has an analeptic and psychostimulant effect and is able to have a direct stimulating effect on the cerebral cortex and stimulate the centers of the medulla oblongata (vasomotor and respiratory centers).

Under the influence of caffeine, physical and mental performance increases, motor activity increases, mental activity is stimulated and fatigue decreases, drowsiness temporarily disappears. If you take caffeine in small doses, then it produces a stimulating effect, and when used in large doses, it depresses the nervous system.

Caffeine has an antispasmodic effect on smooth muscles, and a stimulant effect on striated muscles.

Pharmacokinetics

Paracetamol is well absorbed from the gastrointestinal tract. The maximum concentration in blood plasma is reached after 15-60 minutes, the half-life from blood plasma is 1-4 hours. It is relatively evenly distributed in the body, 20-30% binds to plasma proteins. It is metabolized in the liver and excreted almost exclusively by the kidneys in the form of conjugated metabolites.

After oral intake caffeine is rapidly absorbed. The maximum plasma concentration is reached within 1 hour, the half-life is approximately 3.5 hours. 65-80% of caffeine is excreted in the urine in the form of 1-methyluric acid and 1-methylxanthine.

Codeine phosphate is well absorbed after oral administration. Approximately 86% of the oral dose is excreted in the urine within 24 hours.

Indications for use

What helps Solpadein? According to the instructions, the drug is prescribed in the following cases:

Headache as well as migraine medium degree expressiveness.
Toothache of moderate intensity.
Myalgia is pain in striated skeletal muscles.
Neuralgia - the appearance of pain due to the development of aseptic inflammation.
Dysmenorrhea is painful menstruation in women.
Sore throat of various origins.
Pain in the joints (arthralgia), accompanying the development of rheumatism.

Also, the drug is used to symptomatically reduce the manifestations of the "cold", the severity of intoxication and body temperature.

Instructions for use Solpadein, dosage

The drug is taken orally after a meal. Dissolve tablets before taking should be dissolved in half a glass of water. Enteric tablets Solpadein Fast are washed down with water.

For adults (over 16 years old), the standard dosage of Solpadeine according to the instructions for use is from 1 to 2 tablets 3 to 4 times a day at intervals of at least 4 hours.

The maximum single dose is 2 tablets, the maximum daily dose is 8 tablets.

Dosages for children aged 12 to 16 years - 1 tablet \ 3 - 4 times a day at intervals of at least 4 hours.

The maximum single dose of Solpadeine is 1 tablet, the maximum daily dose is 4 tablets.

The drug should not be taken for more than 5 days when prescribed as an anesthetic and for more than 3 days as an antipyretic.

Side effects

The instruction warns of the possibility of developing the following side effects when prescribing Solpadein:

Allergic reactions (rash, urticaria, angioedema), constipation, nausea, dizziness, insomnia or drowsiness.
Excitability due to stimulation of the central nervous system.
With prolonged use, a hepatotoxic effect of the drug may be observed.

Contraindications

It is contraindicated to prescribe Solpadein in the following cases:

increased systemic blood pressure(arterial hypertension);
promotion intraocular pressure(glaucoma);
periodic attacks of pronounced convulsions of the striated skeletal muscles(epilepsy);
various sleep disorders;
simultaneous use of other non-steroidal anti-inflammatory drugs, in particular those containing paracetamol;
a pronounced decrease in the functional activity of the liver and kidneys;
individual intolerance to any of the components of the drug;
age up to 12 years.

With caution, the drug is used for concomitant liver damage, including alcoholic and viral hepatitis, a benign increase in the level of bilirubin in the blood (Gilbert's syndrome), deficiency of the enzyme glucose-6-phosphate dehydrogenase, and chronic alcoholism.

Before you start taking Solpadeine, it is important to make sure that there are no contraindications.

Overdose

In case of an overdose of the drug, you should immediately seek medical help, even if you feel well.

Symptoms of an overdose are due to the hepatotoxic effect of paracetamol - nausea, vomiting, discomfort in the epigastrium.

If such phenomena are detected, gastric lavage should be done, adsorbents (activated charcoal) should be prescribed, and symptomatic therapy should be carried out.

Analogues Solpadein, price in pharmacies

If necessary, you can replace Solpadein with an analogue of the active substance - these are drugs:

Panadol Extra,
Migrenol,
streamol plus,
Paralen Extra.

ATX code:

Gevadal,
Kaffetin,
corflu,
migraine,

When choosing analogues, it is important to understand that the instructions for use Solpadein, price and reviews of drugs similar action do not apply. It is important to consult a doctor and not to make an independent replacement of the drug.

Price in Russian pharmacies: soluble tablets Solpadein Fast 8 pcs. - from 115 to 138 rubles, tablets 12 pcs. - from 78 to 97 rubles, according to 593 pharmacies.

Store at a temperature not exceeding 25 °C. Keep away from children. Shelf life: tablets and capsules - 5 years; soluble tablets - 4 years.

Solpadeine is an analgesic drug containing in its composition a combination of 3 main components: codeine, paracetamol and caffeine.

Codeine and paracetamol have analgesic, antipyretic effect. They help improve pain tolerance. Caffeine reduces the feeling of fatigue, increases physical endurance and mental alertness.

Compound

The drug is available in several forms: in the form of capsule-shaped and soluble tablets. It contains a mixture of 3 ingredients: paracetamol, codeine phosphate hemihydrate, as well as other auxiliary components: magnesium stearate, corn starch, stearic acid, ethanol, microcrystalline cellulose, povidone, potassium sorbate, carmazine and others.

Doctors recommend taking the drug orally after eating. The rules of treatment with this medication depend on the age of the person. Adults and children over 16 years of age can drink 1 to 2 tablets 3 to 4 times a day. The interval between the use of tablets should not be 4 hours. In this case, the maximum allowable single dose is 2 tablets, and the daily dose is 8 tablets.

Children whose age ranges from 12 to 16 years should take 1 to 4 tablets per day. The maximum allowable single dose is 1 tablet, and the daily dose is 4 tablets.

What does Solpadein help with?

This drug is effective with pain sensations of various etiologies. It is recommended for children over the age of 12, as well as adults with pain syndrome. Solpadeine normalizes body temperature in pathologies of a cold, infectious and inflammatory nature.

Contraindications

Among the contraindications to the use of this medication, conditions such as:

deficiency of glucose-6-phosphate dehydrogenase;
respiratory failure;
pregnancy and lactation;
elderly age;
diseases of the circulatory system;
glaucoma - a group of eye diseases characterized by an increase in intraocular pressure with the subsequent development of visual defects;
high blood pressure;
violation of the functioning of the liver and kidneys;
hypersensitivity to the ingredients present in the composition of this medication;
bronchial asthma;
children's age up to 12 years.

Adverse reactions

In medical practice, a small number of cases have been recorded with the occurrence of adverse reactions against the background of the use of this drug. Typically, this action occurs when improper treatment Solpadein. Therefore, it is very important to take this medication strictly according to the instructions.

If you use this medicine incorrectly, you may experience the following:

skin rash;
sleep disturbance;
pain in the stomach;
sweating;
noise in ears;
confused mind;
dizziness;
constipation;
angioedema;
nausea;
anemia;
cardiopalmus;
thrombocytopenia;
convulsions and other unpleasant symptoms.

If you feel unwell while taking this medicinal product- stop using this medication, consult a doctor and, if necessary, do a gastric lavage and drink activated charcoal.

Best before date

This drug must be stored in a dark place, out of the reach of children, at a temperature not exceeding 25°C. The shelf life of the drug depends on the form of its release and varies from 4 to 5 years.

Photo of the drug

Latin name: Solpadein

ATX code: N02BE51

Active substance: Codeine (Codeine), Caffeine (Caffeine), Paracetamol (Paracetamol)

Manufacturer: Glaxo Wellcome Production (France), GlaxoSmithKline Dungarvan (Ireland)

The description applies to: 27.10.17

Solpadeine is a combination drug from the group of analgesics-antipyretics.

Active substance

Codeine (Codeine), Caffeine (Caffeine), Paracetamol (Paracetamol).

Release form and composition

Available in three dosage forms:

Tablets are white, capsule-shaped, elongated, with a red label "Solpadeine" on one side. Packed in blisters of 5, 6, 8 and 12 pieces.
Soluble tablets are white, flat, beveled, smooth on one side and scored on the other. Packed in strips of 2 pieces.
Capsules hard gelatin, size No. 0, opaque, with a red to red-brown cap and a white body, printed on both sides of the capsule in black "Solpadeine". The contents of the capsules are a white amorphous powder with inclusions of crystals. Packed in blisters of 6 and 12 pieces.

Indications for use

Pain syndrome of mild to moderate intensity:

headache;
migraine;
ossalgia;
myalgia;
neuralgia;
arthralgia;
pain with sciatica;
algomenorrhea;
toothache;
sinus pain;
sore throat;
post-traumatic pain;
febrile syndrome, incl. with colds.

Contraindications

anxiety disorders (agoraphobia, panic disorder);
organic diseases of cardio-vascular system(incl. acute infarction myocardium, atherosclerosis);
paroxysmal tachycardia, frequent ventricular extrasystole;
arterial hypertension;
pulmonary heart failure, bronchial asthma, diseases accompanied by sputum hypersecretion;
sleep disorders;
alcohol intoxication;
severe renal and / or liver failure;
blood diseases (thrombocytopenia, anemia);
oppression of hematopoiesis (agranulocytosis, neutropenia);
hypocoagulation;
condition after traumatic brain injury;
increased intracranial pressure, epilepsy;
pregnancy, prenatal period and lactation (breastfeeding);
children's age up to 12 years;
increased individual sensitivity to paracetamol, codeine, caffeine or any other ingredient of the drug.

Assign with caution in the following pathologies and conditions:

benign hyperbilirubinemia (including Gilbert's syndrome, Dubin-Johnson syndrome);
viral hepatitis;
alcoholic liver damage;
alcoholism;
deficiency of glucose-6-phosphate dehydrogenase;
glaucoma;
increased excitability;
tendency to convulsive seizures;
elderly age.

Instructions for use Solpadein (method and dosage)

Tablets

Taken orally after meals. Dissolve tablets before taking should be dissolved in half a glass of water.

Adults and children over 16 years old: 1 - 2 tab. 3 - 4 times a day at intervals of at least 4 hours. The maximum single dose is 2 tablets, the maximum daily dose is 8 tablets.
Children aged 12 to 16 years: 1 tab. 3 - 4 times a day at intervals of at least 4 hours. The maximum single dose is 1 tab., The maximum daily dose is 4 tab.

The drug should not be taken for more than 5 days when prescribed as an anesthetic and for more than 3 days as an antipyretic. Changing the dose and the interval between doses is set by the doctor.

Capsules

Single dose for adults: 2 capsules at a time. Repeated use is possible with an interval of at least 4 hours and no more than 4 times a day. The maximum daily dose should not exceed 8 caps.
A single dose for children aged 12 to 16 years - 1 caps. Repeated use is possible with an interval of at least 4 hours and no more than 4 times a day. The maximum daily dose should not exceed 4 caps.

Should not be used in children under 12 years of age. Do not exceed the recommended dose.

The maximum duration of the drug without consulting a doctor is no more than 5 days as an anesthetic and no more than 3 days as an antipyretic.

Side effects

V rare cases Solpadeine can cause such allergic reactions:

skin rash;
angioedema;
bronchospasm;
hives.

Active substances can cause the following side effects:

Paracetamol: leukopenia, agranulocytosis, hemolytic anemia, thrombocytopenia, methemoglobinemia. With prolonged use in high doses, the likelihood of impaired liver and kidney function increases.
Codeine: constipation, nausea, vomiting, gastralgia, dizziness, drowsiness, sleep disturbance, palpitations, tachycardia.
Caffeine: arousal, anxiety, headache, palpitations, tachycardia, arrhythmias, increased blood pressure.

Overdose

In case of an overdose of Solpadeine, you should immediately seek medical help, even if you feel well.

Symptoms of an overdose are due to the hepatotoxic effect of paracetamol:

nausea;
vomit;
feeling of discomfort in the epigastrium.

If such phenomena are detected, gastric lavage should be done, adsorbents (activated charcoal) should be prescribed, and symptomatic therapy should be carried out.

Analogues

Drugs with a similar mechanism of action (level 4 ATC code match): Acetaminophen, Efferalgan, Cefecon D, Kalpol, Panadol, Paracetamol, Tylenol, Rinza, Rinzasip, Sedalgin-neo, Caffetin, Migrenol, Toff Plus.

Do not make the decision to change the drug yourself, consult your doctor.

pharmachologic effect

The medicinal properties of Solpadein are due to the action of the active substances that make up its composition.

Non-narcotic analgesic Paracetamol has an analgesic and antipyretic effect, stops COX1 and COX2 mainly in the central nervous system, affecting the centers of thermoregulation and pain.
The alkaloid of the phenanthrene series codeine has an antitussive effect of the central type (depresses the excitability of the cough center) and has an analgesic effect.
Caffeine has an analeptic and psychostimulant effect and is able to have a direct stimulating effect on the cerebral cortex and stimulate the centers of the medulla oblongata (vasomotor and respiratory centers). Under the influence of caffeine, physical and mental performance increases, motor activity increases, mental activity is stimulated and fatigue decreases, drowsiness temporarily disappears. If you take caffeine in small doses, then it produces a stimulating effect, and when used in large doses, it depresses the nervous system. Caffeine has an antispasmodic effect on smooth muscles, and a stimulant effect on striated muscles.

special instructions

Precautions should be prescribed for diseases of the liver or kidneys, impaired bowel function (including constipation), after surgery to remove the gallbladder, while taking antiemetic drugs (metoclopramide or domperidone), drugs that can cause drowsiness (hypnotics, sedatives , tricyclic antidepressants, tranquilizers from the phenothiazine group), MAO inhibitors, indirect anticoagulants (warfarin), ethanol.
It should not be taken concomitantly with other drugs containing paracetamol or codeine.
With prolonged use in doses significantly higher than recommended, it is necessary to control the picture of peripheral blood.
When adverse reactions occur digestive system(abdominal pain, nausea and vomiting), allergic reactions (skin itching or redness of the skin, difficulty breathing or swelling of the lips, tongue, throat or face), rash or peeling on the skin, formation of sores on the oral mucosa, bruising and bleeding should stop taking medication and contact your doctor immediately.
While taking the drug, excessive consumption of tea and coffee is not recommended, because. this can lead to agitation, sleep disturbance, tachycardia, cardiac arrhythmias.
Increase daily dose or duration of treatment is possible only after consulting a doctor.
With prolonged uncontrolled use of the drug in large doses, addiction (weakening of the analgesic effect) and drug dependence may develop.
To avoid toxic injury the liver is not combined with the intake of ethanol.
During treatment, care must be taken when administering vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

During pregnancy and breastfeeding

Contraindicated during pregnancy and lactation.

In childhood

Contraindicated under the age of 12 years.

In old age

Caution should be given to elderly patients.

For impaired renal function

Contraindicated in severe renal failure.

For impaired liver function

Contraindicated in severe liver failure. With caution should be prescribed for viral hepatitis, alcoholic liver damage.

drug interaction

Barbiturates, rifampicin, salicylamide, antiepileptic drugs and other inducers of microsomal oxidation contribute to the formation of toxic paracetamol metabolites that adversely affect liver function.
Metoclopramide accelerates the absorption of paracetamol.
When taken repeatedly, paracetamol may increase the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding.
Caffeine accelerates the absorption of ergotamine.
Simultaneous use of paracetamol and ethanol increases the risk of hepatotoxic effects.
Inhibitors of microsomal oxidation reduce the risk of hepatotoxic effects of paracetamol.
Codeine may potentiate the effect of CNS depressants (including alcohol); however, the specified action with its quantitative content in this dosage form drug is insignificant.

Terms of dispensing from pharmacies

Released by prescription.

Terms and conditions of storage

Keep out of the reach of children at a temperature not exceeding +25°C.

Shelf life - 5 years.

Price in pharmacies

The price of Solpadein for 1 pack starts from 80 rubles.

Attention!

The description posted on this page is a simplified version of the official version of the annotation for the drug. The information is provided for informational purposes only and is not a guide for self-treatment. Before using the drug, you should consult with a specialist and read the instructions approved by the manufacturer.

Prices in online pharmacies:

Prohibited during pregnancy

Prohibited at breastfeeding

Forbidden to children

Has restrictions for the elderly

Has limitations for liver problems

Forbidden for kidney problems

Solpadeine is a drug that has an impressive list of indications for use, thanks to the combination of several active ingredients. The drug is most often used to eliminate the symptoms of colds and flu, but it gained its popularity due to its strong analgesic effect.

The medication contains in its composition 2 painkillers at once - paracetamol and codeine, as well as a central nervous system stimulant - caffeine, which enhances the action of the components. Due to the prevalence and availability of the drug, it is worth studying in detail the instructions for the use of Solpadein in order to clearly understand what the drug helps with and when its use is undesirable.

General information about the drug

The combined preparation of foreign production (Spain, France, Great Britain) has analgesic and antipyretic effects, as well as an antitussive effect. Such a complex effect is achieved due to the effect of paracetamol on the centers of cough, thermoregulation and pain sensitivity by reducing the formation of prostaglandins. And codeine, in turn, enhances the analgesic effect of the drug and acts as a non-narcotic analgesic.

Drug group, INN, scope

Pharmacotherapeutic group - non-narcotic analgesic and antipyretic. INN - Paracetamol, combinations excl. psycholeptics.

Thanks to his unique composition, the medication has a wide scope and is used not only as an analgesic for pain of various nature and genesis, but also for colds and infections of the upper respiratory tract as symptomatic therapy.

Forms of release and prices for the drug, average in Russia

The drug is sold in cardboard boxes that contain 12 tablets or capsules placed in a blister. Available in three forms:

Coated tablets.
Soluble (effervescent) tablets of white color, intended for the preparation of a solution.
Capsules are hard with hemispherical and convex edges, red-white color. Contains white powder in the form of granules.

The price of Solpadein depends solely on the form of release. Estimated cost is shown in the table.

Compound

The drug is a combination medication, which is based on paracetamol (500 mg), caffeine (30 mg), codeine phosphate hemihydrate (8 mg). The number of components in the composition is indicated based on 1 tablet / capsule.

The auxiliary components are: corn and soluble starch, cellulose (microcrystalline), talc, 95% ethanol, stearic acid, carmazine and water (demineralized).

The composition of Solpadein includes a unique combination of active ingredients:

acts as an antipyretic and analgesic agent.
Caffeine tones the body, eliminating drowsiness and increasing efficiency.
Codeine is an opioid analgesic.

Pharmacodynamics and pharmacokinetics

The active ingredients have the following effects:

The drug is rapidly absorbed in the gastrointestinal tract and enters the body, practically without binding to blood proteins. It is excreted mainly by the kidneys. The half-life of paracetamol is 2.3 hours, codeine is 3-4 hours, and caffeine is 4-5 hours.

Indications and contraindications

Indications for taking the drug are due to the combined effect of 3 medicinal components at once, in which paracetamol acts as the main component, and caffeine with codeine enhance its effectiveness.

This drug is prescribed in the following cases:

Cephalgia and migraine.
Pain in teeth and gums.
Rheumatic and muscular pain.
Pain in the joints.
Periodic pain in women.
Cold or flu symptoms to relieve symptoms (sore throat, fever).

allergy to substances in the composition;
glaucoma;
blood diseases (anemia, thrombocytopenia);
obvious dysfunction of the kidneys and liver;
recovery period after traumatic brain injury;
high intracranial pressure;
hypertension;
respiratory failure;
diseases of the cardiovascular system;
epilepsy;
pancreatic dysfunction ( diabetes, acute pancreatitis);
thrombophlebitis;
congenital absence of glucose-6-phosphate dehydrogenase;
alcoholism.

The drug should also be taken with caution when bronchial asthma, hyperbilirubinemia and in old age. Not approved for children under 12 years of age.

The drug is not taken during pregnancy or childbirth due to the possibility of respiratory failure in the child. During breastfeeding, it is also worth refraining from using Solpadein. If the breakdown products of codeine enter the child's body, serious conditions develop, such as sleep, swallowing and breathing disorders, which can lead to the death of the infant.

Instructions for use

The instructions for the drug Solpadein contain precise instructions regarding the single and maximum daily dosage of the drug that is safe for humans, so it requires careful study.

The drug is intended for oral administration 1-2 tablets at a time, but not more often than after 4 hours. It is allowed to take no more than 8 tablets per day. The maximum course of treatment without consulting a doctor is 3 days. In the case of using effervescent tablets, only a freshly prepared solution is taken.

Important to consider special instructions on the use of the drug:

Possible side effects and overdose

Adverse reactions while taking Solpadein, as a rule, occur due to violations of the dosage, prolonged use of the drug, individual susceptibility of the human body and the presence of an allergy to the components of the composition.

Symptoms of side effects:

With prolonged use of the drug in high doses, a general deterioration in the state of the body occurs, which is accompanied by the symptoms indicated in the table.

Substance name	Manifestations of an overdose
Paracetamol	liver and kidney failure; pallor; nausea and vomiting; violation of coordination and orientation in space; anemia; abdominal pain; anorexia; encephalopathy; pancreatitis; coma (hypoglycemic); death.
Codeine	severe vomiting; drowsiness; respiratory failure; cyanosis; pulmonary edema; increased blood pressure; cardiopalmus; convulsions; collapse; urinary retention; substance dependence.
Caffeine	flushes of blood to the face; rapid breathing; diuresis; irritability and rapid excitability; incoherence of thought and speech.

Treatment of poisoning with Solpadeine in the first hour after intoxication includes gastric lavage, enema and taking activated carbon. It is also necessary to ensure a good flow of air to the patient.

If the symptoms of an overdose began to appear later, then it is imperative to consult a doctor, since therapy involves the administration of antidotes and instrumental and laboratory monitoring of the patient's vital signs (respiratory rate and heart rate, pressure and blood tests).

Analogues

The drug consists of fairly common and affordable substances that are complexly used in the production of various pharmacological companies, so Solpadein has many analogues: