Tizalud tablets: instructions for use. Tizalud - instructions for use

Thyzalud is a centrally acting muscle relaxant. Instructions for use reports that 2 mg and 4 mg tablets help with muscle spasms in osteochondrosis and after a stroke in adults, children and pregnancy.

Composition and form of release

Tizalud is available in the form of tablets: white with a yellow tint or white, round, biconvex, with a dividing risk of 2 mg or 4 mg. Sold by 10 pieces in blister packs, in a cardboard bundle 3 packs, 30 pcs. in polymeric banks, in a cardboard pack 1 bank. 1 tablet contains the active substance: tizanidine hydrochloride - 2 mg or 4 mg.

What helps Tizalud?

Tablets are intended for oral administration. The main indications for prescribing the drug are the following conditions:

spastic muscle pain caused by neurological pathologies, for example, multiple sclerosis, chronic myelopathy, cerebral palsy;
pain in the spine and muscle spasms caused by surgical interventions (after an operated herniated disc, for example);
muscle spasms associated with severe pain and caused by diseases of the cervical and lumbar spine;
degenerative diseases of the spinal cord, against which muscle spasms occur;
as part of complex therapy for the consequences of cerebrovascular accident.

Important! Only a doctor should decide on the need for course pharmacotherapy. Self-medication is absolutely unacceptable.

Instructions for use

Tizalud tablets are taken orally (by mouth) with water, regardless of food.

Instructions for the use of Tizalud in neurological pathologies that cause spastic painful muscle contraction recommend starting treatment with a daily dose of 6 mg, taken in three divided doses. Each subsequent 3-7 days, depending on the nature of the pain and spasm, increase the dose by 2-4 mg. The maximum therapeutic effect is observed when taking a daily dose of 12-24 mg. A dose of 36 mg is the maximum allowable daily dose.

To stop the pain spasm of skeletal muscles, a 3-time daily intake of Tizalud, 2-4 mg, is prescribed. In especially severe situations, an additional intake of 2-4 mg at night is recommended.

The duration of taking Tizalud depends on the dynamics of pain and muscle-tonic manifestations. Acute muscle pain usually requires therapy for 7-21 days. Chronic pain syndrome, depending on the origin and severity, may require more long-term treatment, which is determined on an individual basis and sometimes lasts for up to 1 year.

Pharmacological effects

The active substance Tizalud belongs to centrally acting muscle relaxants. The drug is effective in the treatment of acute painful muscle spasms and chronic spasms of cerebral and spinal origin. Taking Tizalud tablets can reduce muscle stiffness during passive movements.

The action of the drug is based on the inhibition of the polysynaptic transmission of excitation in the spinal cord, in which the regulation of tone occurs. skeletal muscles. Tizalud, according to the instructions, can cause a “withdrawal” syndrome, therefore, at the end of treatment, the dose must be reduced gradually.

Contraindications

According to the instructions Tizalud contraindicated to take:

During lactation;
In pediatrics;
Simultaneously with potent inhibitors of the CYP1A2 isoenzyme;
Against the background of hypersensitivity to the active (tizanidine) or auxiliary components that make up the tablets;
During pregnancy;
Against the background of severe liver failure.

With extreme caution, you should take Tizalud tablets:

Against the background of hepatic or renal insufficiency;
With the syndrome of congenital prolongation of the Q-T interval;
Against the background of bradycardia;
Simultaneously with oral contraceptives;
Elderly people over 65;
With arterial hypotension.

Side effects

insomnia;
drowsiness;
nausea;
bradycardia;
increased activity of transaminases in serum;
dry mouth;
dizziness;
feeling tired;
muscle weakness;
some decrease in blood pressure.

drug interaction

Tablets the drug should not be administered simultaneously with diuretics and drugs for the treatment arterial hypertension. Given drug interaction requires special care due to the risk of a rapid drop in blood pressure, bradycardia and cardiac arrhythmias.

It is not recommended to administer Tizalud tablets to the patient simultaneously with Fluvoxamine or Ciprofloxacin, since this drug interaction causes a sharp and prolonged decrease in blood pressure, accompanied by loss of consciousness, lethargy, severe dizziness, and a decrease in the speed of psychomotor reactions. In severe cases, this drug interaction leads to collapse.

The drug Tizalud is not prescribed simultaneously with antiarrhythmic drugs, fluoroquinolones, oral contraceptives due to an increased risk of side effects from organs. gastrointestinal tract and liver.

With the simultaneous use of tablets of the drug with sedatives, antihistamines or sleeping pills, the sedative effect of Tizanidine increases.

With particular caution, Tizalud tablets should be prescribed to patients receiving Azithromycin, Cisapride therapy. This drug interaction increases the risk of complications and severe side effects from the heart and blood vessels.

Special conditions

Due to the threat of developing a “withdrawal syndrome”, when therapy is abandoned, the dose of tizanidine is reduced gradually.

When conducting long-term treatment with Tizalud, the condition of the liver should be monitored at least once a month, especially during the first 4 months of therapy.

When taking pills, it is better to refuse to drive vehicles and carry out precise or dangerous work.

Tizalud's analogs

Analogues are prescribed for treatment:

Tizanil.
Tizanidine hydrochloride.

Price and holiday conditions

The average price of Tizalud, 2 mg tablets, 30 pieces (Moscow), is 145 rubles.

Tablets can be purchased from pharmacies with a doctor's prescription. The shelf life of the drug from the date of manufacture is 5 years. Keep the package of tablets Tizalud instructions for use in a place inaccessible to children, avoiding direct sunlight.

Veropharm, JSC

Country of origin

Russia

Product group

Nervous system

Centrally acting muscle relaxant

Release form

10 - blisters (3) - packs of cardboard. 30 - polymer bottles (1) - cardboard packs. 30 - polymer cans (1) - packs of cardboard. 30 - dark glass jars (1) - cardboard packs.

Description of the dosage form

tablets

pharmachologic effect

Muscle relaxant of central action. Reduces the increased tone of skeletal muscles, relieves their spasm; reduces muscle resistance during passive movements, increases the strength of voluntary contractions. The muscle-relaxing effect of tizanidine is probably due to the inhibition of spinal polysynaptic reflexes, which is associated with a decrease in the release of excitatory amino acids from the presynaptic terminals of spinal interneurons, as well as stimulation of alpha2-adrenergic receptors. Tizanidine does not affect the transmission of excitation in neuromuscular synapses.

Special conditions

Use with caution in patients with impaired liver and kidney function. Influence on the ability to drive vehicles and control mechanisms At the beginning of treatment, if drowsiness occurs, activities that require a high concentration of attention, fast psychomotor reactions should be avoided.

Composition

tizanidine (in the form of hydrochloride) 2 mg excipients: lactose, microcrystalline cellulose, sodium carboxymethyl starch, magnesium stearate tizanidine (in the form of hydrochloride) 4 mg excipients: lactose, microcrystalline cellulose, sodium carboxymethyl starch, magnesium stearate

Tizalud indications for use

Spastic condition of skeletal muscles caused by neurological diseases (multiple sclerosis, chronic myelopathy, stroke, degenerative diseases of the spinal cord). Painful skeletal muscle spasm due to damage to the spine (cervical and lumbar syndromes) or occurring after surgery (for a herniated disc or hip osteoarthritis).

Tizalud contraindications

Hypersensitivity to tizanidine.

Thizalud dosage

2 mg 4 mg

Thizalud side effects

When using tizanidine in relatively small doses in rare cases observed drowsiness, fatigue, dizziness, dry mouth, nausea, some decrease in blood pressure; in higher doses - these effects occur more often and are more pronounced, in addition, insomnia, muscle weakness, bradycardia, increased serum transaminase activity are possible

drug interaction

With simultaneous use with antihypertensive agents (including diuretics), severe arterial hypotension and bradycardia may develop. With the simultaneous use of ethanol, drugs with a sedative effect, the sedative effect is enhanced.

Storage conditions

keep away from children

Information provided

Tizalud tablets are a drug designed to relieve muscle spasms.

The drug has a wide range of contraindications and many side effects, so you need to take it in strict accordance with the instructions developed by the manufacturer and according to the prescriptions of doctors.

General characteristics of the drug

The release of the drug Tizalud is carried out by the Russian pharmaceutical company Veropharm. The drug is a white cylindrical tablet with beveled edges and a risk on one of the surfaces. Each of them contains 2 or 4 mg of the active ingredient. The manufacturer packs tablets of 10 pcs. in blister packs made of PVC and aluminum foil.

In pharmacies, the medicine is sold in cardboard packs, each of which contains 3 blisters with medicines and a leaflet with instructions for use.

Tizalud tablets can only be bought with a doctor's prescription. The price of the drug depends on the concentration active substance and varies between 120-190 rubles per standard pack. The drug must be stored in its original packaging at temperatures up to 25 ° C. It is important to ensure that it is not exposed to moisture and direct sunlight. Subject to the described conditions, the drug retains its pharmacological and organoleptic properties for 36 months. Unused expired tablets must be discarded.

Composition and pharmacological action

The main active ingredient in Tizalud is tizanidine hydrochloride. Once in the human body, this component stimulates the work of presynaptic α2-adrenergic receptors, inhibits the release of "excitatory" amino acids (glutamic, aspartic) and suppresses polysynaptic transmission of impulses at the level of spinal cord interneurons. Because of this, tizanidine hydrochloride:

eliminates muscle spasms;
relieves clonic convulsions;
reduces resistance to passive movements;
increases the strength of voluntary muscle contractions;
exhibits moderate analgesic properties.

Auxiliary components in the composition of the drug are anhydrous lactose, microcrystalline cellulose, stearic acid and aerosil.

Indications for appointment

The active ingredient of the drug acts as a centrally acting muscle relaxant, so the main indications for the use of Tizalud are:

spasticity of skeletal muscles in multiple sclerosis, cerebral palsy, chronic myelopathy, degenerative processes in the tissues of the spinal cord and other neurological pathologies;
pain syndrome and muscle spasms that accompany the development of functional and static diseases of the spinal column (lumbar and cervical).

In addition, the drug is used to relieve muscle cramps that occur after surgery for osteoarthritis. hip joint and herniated disc.

Reception scheme

Tizalud is taken orally with a small amount of non-carbonated water. The tablets are swallowed whole, without chewing or dissolving. With painful muscle spasms, patients are prescribed 2-4 mg of the drug three times a day. In severe cases, the daily dose of the drug is increased by 2 mg.

In cases where Tizalud is prescribed to relieve skeletal muscle spasticity, a more complex dosing regimen is used. In the first week, patients take 2 mg medicinal product three times a day. Then daily dose the drug is increased by 2-4 mg with an interval of 72-96 hours. Most patients are able to achieve optimal therapeutic effect when taking 12-24 mg of tizanidine hydrochloride per day.

Persons who have previously been diagnosed with renal failure are prescribed 2 mg of the drug per day. The initial dose is increased gradually, taking into account the tolerability of the drug and the effectiveness of therapy. First of all, the volume of the drug is increased, and only then - the frequency of administration.

With acute pain syndrome caused by muscle spasm, the drug is taken for 2-3 weeks. At chronic pain the patient may require a longer course of therapy (from several months to a year). If necessary, the doctor can adjust the treatment regimen, taking into account the dynamics of pain and muscle-tonic manifestations of the disease.

Taking more than 36 mg of tizanidine hydrochloride per day can cause dizziness, nausea, drowsiness, vomiting, increased anxiety, disturbances in work respiratory system, lowering blood pressure, constriction of the pupils and falling into a coma.

If one or more signs of an overdose are detected, it is necessary to cancel the medicine, rinse the stomach, take diuretic drugs and activated charcoal. In addition, you should consult a doctor as soon as possible.

Side effects

Most patients tolerate treatment with Tizalud with ease. Undesirable effects of the drug are rare. These include:

daytime sleepiness or insomnia at night;
general weakness, increased fatigue;
a significant decrease in blood pressure;
dizziness;
violation of sinus rhythm (bradycardia);
nausea;
hallucinations;
muscle weakness;
dry mouth, constant thirst;
increased activity of hepatic transaminases;
digestive disorders;
acute inflammation of the liver.

The components present in the composition of Tizalud can provoke the development of allergic reactions in the form of urticaria, skin itching, rashes, swelling of facial tissues, etc.

Contraindications for use

Tizalud is not suitable for all patients who complain of muscle spasms. Most often, the individual intolerance to tizanidine hydrochloride and auxiliary components of the drug becomes the basis for refusing to use this drug. Contraindications to the appointment of tablets are:

age under 18;
simultaneous treatment with fluvoxamine;
severe functional failures in the liver;
pregnancy;
breastfeeding period.

In patients taking Tizalud, the speed of psychomotor reactions and concentration of attention may decrease, therefore the manufacturer recommends that persons undergoing therapy with this medication temporarily stop driving and other complex technical devices.

Drug analogues

On the modern pharmaceutical market, you can find many analogues of the drug Tizalud for the active ingredient and healing properties. These include:

tablets Tizanil, Lioresal, Tolperison, Mydocalm, Baclofen, Sirdalud, Tolperil-Health, Myolastan, Tizanidin and Baclosan;
prolonged action capsules Miorix;
solutions for intramuscular injection Meloflex, Muskomed, Miaxil and Midostad Combi.

All centrally acting muscle relaxants included in this group have a lot of features in use, harmful effects, absolute and relative contraindications, therefore, they can be used as an alternative to Tizalud tablets only with the consent of the attending physician.

"Tizalud" is a drug whose main goal is to eliminate seizures and reduce the number of spasms in skeletal muscles. The desired effect is achieved thanks to tizinidine, the main active substance of the medical preparation.

The composition of the drug

One tablet contains 2 or 4 mg of tizanidine. Excipients: sodium carboxymethyl starch, anhydrous lactose, magnesium, microcrystalline cellulose.

Medicinal properties

"Tizalud" is a muscle relaxant drug of central action. It effectively helps to eliminate acute muscle spasms, as well as spasms in spinal etiology. Also, this drug relieves inflammation and swelling of the affected joints.

Excreted "Tizalud" bile and urine.

Indications for use

The use of "Tizalud" is effective in such diseases and conditions:

Spasm of skeletal muscles, which was caused by damage to the vertebrae
Spasm in the cervical and lumbar regions
Pathologies of the spine, which are accompanied by acute pain
Multiple sclerosis, which causes a spastic condition of the skeletal muscles
Degenerative diseases of the spinal cord
Herniated disc
Osteoarthritis of the hip
Pain after surgery
hemiplegia
Myelopathy
Cerebral paralysis
Stroke
Circulatory disorder
Seizures.

Release form

The average price is from 120 to 150 rubles.

This drug is available in the form of tablets in a dosage of 2 and 4 mg. One package of "Tizalud" tablets contains 30 pcs. Odorless tablets.

Mode of application

Apply "Tizalud" is intended inside.

To relieve muscle spasm, you need to take 2 mg three times a day. In especially severe cases, the dose can be increased to 4 mg per day.

The total duration of therapy is determined by the attending physician, depending on the susceptibility of the organism, symptoms and severity of the disease.

During pregnancy and breastfeeding

"Tizalud" tablets should not be used during pregnancy, except in cases where the benefit to the expectant mother will be greater than the possible risks to the fetus.

However, if there is a need for treatment with "Tizalud" during lactation, because of which the child may suffer, then the question of stopping breastfeeding should be raised.

Since the drug is prohibited for use by pregnant women, you need to know other, safer ways to treat seizures, which you can read about in the article:.

Contraindications

The drug has such contraindications:

Age under 18
Pregnancy
lactation period
Severe liver disease
Individual intolerance to the components of the drug
The period after a stroke
Simultaneous therapy with the drug Ciprofloxacin.

Precautionary measures

It is necessary to take the drug with caution under such circumstances:

Old age (over 60 years old)
arterial hypotension;
Acute renal failure
Deterioration of the liver.

Interaction with other drugs

This drug can not be combined with CYP1A2 isoenzyme inhibitors - antiarrhythmic drugs:

Cimetidine
Pefloxacin
Ticlopidin
Norfloxacin
Fluvoxamine
Amiodarone.

Also, the substance tizanidine cannot be combined with ethanol and antihypertensive drugs, as this increases the risk of bradycardia and increased blood pressure.

Tizanidine should not be taken with alcoholic beverages, as this may cause side effects in the patient.

Side effects

This drug may cause the following side effects:

In the nervous system:
- Drowsiness or, conversely, loss of sleep
- Dizziness and headaches
- hallucinations
- Seizures.
In the digestive system:
- Diarrhea, nausea
- Hepatitis
- Constipation
- Heartburn and dry mouth
- Increased liver enzymes.
In the cardiovascular system:
- A sharp drop in blood pressure
- Collapse
- Loss of consciousness
- Arrhythmia or tachycardia
- Bradycardia.
Other side effects:
- Loss of strength, weakness and fatigue
- Pain in the muscles
- Violation of cerebral circulation.

Overdose

In case of an overdose, the patient may experience the following symptoms:

Nausea
Increase in blood pressure
convulsions
Heavy breathing
Nervousness and anxiety
Dizziness
hypotension
Drowsiness.

Terms and conditions of storage

The drug must be stored in a dry and dark place at a temperature of no more than 25 degrees.

Expiration date: 2 years from the production date indicated on the package.

Analogues

Tizalud has such medicinal analogues:

Novartis Pharma, Switzerland
Price from 200 to 230 rubles.

Main action: centrally acting muscle relaxant. Reduces spasticity in the patient, as well as convulsions. It is prescribed for chronic myelopathy, multiple sclerosis, paralysis and many other diseases. Release form: round white tablets packed in a foil blister.

pros

Effectively relieves muscle spasms
Helps relieve pain after surgery

Minuses

Contraindicated in renal failure
Not recommended for use in the elderly.

Polpharma, Poland
Price from 240 to 270 rubles.

Main action: centrally acting muscle relaxant. It is prescribed for neurological diseases. Ingredients: baclofen - 25 mg.

pros

Increases movement in affected joints
Absorbed quickly.

Minuses

Contraindicated in pregnancy
Not recommended for atherosclerosis.

« «

Teva Private, Hungary.
Price from 150 to 200 rubles.

Main action: centrally acting muscle relaxant. Reduces the tone of skeletal muscles and relieves spasm. It also reduces muscle resistance during movements and increases their contractions. Composition: tizanidine - 4 mg. Available in the form of white tablets. which on one side have a characteristic engraving "T2".

pros

Relieves pain from injuries of the spine and joints
Improves blood circulation

Minuses

Does not mix well with other drugs
Contraindicated for use with kidney failure.

Some facts about the product:

Instructions for use

Price in the online pharmacy site: from 143

Some facts

Targeted muscle relaxant. It has a positive effect on the quality and speed of muscle contractions. It is a moderate analgesic, which is important for the treatment of seizures, spasmodic syndromes. Relieves pain, eliminates the effects of neurological diseases, including stroke and multiple sclerosis.

The drug is used for the prevention of disorders, sclerotic nature, functional disorders of the brain, spinal cord.

Pharmacological properties

Tizalud belongs to the group of muscle relaxants, which are characterized by a pronounced centralized action. The active ingredients stimulate alpha-2 receptors of presynaptic origin, which slows down the release of aspartic and glutamic acids. These substances directly stimulate the corresponding receptors, which inhibits the polysynaptic transmission of excitatory impulses.

Thanks to this phenomenon, a qualitative, gradual relaxation of the skeletal muscles occurs. In addition to the analgesic effect, indications for partial inhibition of the functional features of the intercalary neurons in the region of the posterior processes (horns) of the spinal cord were recorded.

During treatment multiple sclerosis, the general resistance to movements, of a passive nature, decreases. As a result, the effects of convulsions and spasms are mitigated. The patient's capabilities are increased in terms of the "mechanics" of movement. The quality of voluntary muscle contraction improves, regardless of concomitant diseases.

Tizalud does not affect the processes of a neuromuscular nature, including the direct transmission of excitation signals. The rate of assimilation, absorption of active substances depends on the dosage and pharmacokinetic characteristics of the drug.

The individual breadth of drug parameters, in terms of pharmacokinetics, is low. The peak concentration of the active substance in the blood plasma occurs 2 hours after a single dose. There is a pronounced effect after the first use, which increases the overall bioavailability of the drug up to 34%.

The effect of active components on plasma proteins of the blood is moderate. The level of binding to protein structures does not exceed 30%. Excretion from the body occurs in the form of inactive metabolites. A larger amount is formed and stored in the liver.

The amount of metabolites passing through the hematoembryonic barrier is small. A small dose of the substance, in unchanged form, is stored in breast milk. The agent acts on the central nervous system 45 minutes after the first dose. The permanent effect of Thezalud lasts for two hours.

Composition and form of release

The drug is sold in the form of round tablets. Supplied in a blister in a standard dose of 2 mg, 10 pieces per plate. Sold in cardboard boxes. The instruction is attached. The active ingredient is tizanidine. Microcrystalline cellulose, magnesium stearate, lactose of anhydrous origin are used as additional components ( possible contraindications in this substance).

Indications for use

Tizalud is used to treat the following pathologies:

spastic complications during multiple sclerosis (individual dosage is relevant);
skeletal muscle spasms of undetectable etiology;
large-scale lesions of the brain, spinal cord.

Side effects

With prolonged therapy, aggressive reactions from the side are possible. of cardio-vascular system, including a sharp decrease in blood pressure, collapses of various origins, bradycardia.

Reception of Tizalud calls for weakness in the body, certain muscle groups, slight dizziness. In rare cases, symptoms of hepatitis, liver failure appear. During regular use of the medicine, it is possible serious violations cerebral circulation.

Abrupt drug withdrawal significantly increases arterial pressure. The composition is taken under the strict supervision of the attending physician. In specific cases, observation in a hospital setting is recommended.

Contraindications

Tizalud tablets are not used for severe functional disorders of the liver, individual hypersensitivity to active ingredients and lactose.

Application during pregnancy

Pregnancy in the 1-3 trimesters is a reason for limiting the intake, and not the complete abolition of this drug. The tool is prescribed solely on the recommendation of a narrow specialist. The ratio of actual benefit and harm to the fetus and the mother's body is taken into account.

Method and features of application

Thyzalud tablets are prescribed for adults, two units (2 or 4 mg) three times a day. In case of complications, one more dose is added, in the late afternoon. The medicine is washed down with clean water, you can use juice or tea. An exception is dairy, sour-milk products, especially for patients suffering from hypersensitivity to lactose and concomitant diseases.

According to the instructions for use, the maximum concentration of the active substance should not exceed 36 mg per day. People suffering from renal insufficiency are prescribed 2 mg of the drug once a day.

Overdose

Such complications are accompanied by vomiting, drowsiness, short-term loss of consciousness, dizziness, accompanied by nausea. The elimination of these symptoms begins with cleansing procedures, including gastric lavage, absorption of absorbents, diuresis.