Candide in dentistry instructions for use. Candide (solution): instructions for use
The cause of candidal stomatitis or thrush in childhood the opportunistic fungus Candida is actively growing. With a decrease immune protection the child begins active reproduction of the fungus. As a result of the vital activity of a colony of fungi, a dense white coating is formed on the surface of the oral mucosa, hiding painful erosions. Quite often, in the treatment of childhood candidal stomatitis, the child is prescribed the drug "Candide".
The form of the drug and composition
Candide is an antifungal agent that belongs to the group of imidazole derivatives. In a pharmacy, you can buy a remedy in the form of a gel, tablets and solution. It is the solution of the drug that is used for stomatitis.
The aqueous solution is offered in dropper bottles with a volume of 15 ml. The consistency of the composition is quite viscous and completely transparent. Active substance drugs - clotrimazole.
- One milliliter of the drug contains ten milliliters of clotrimazole.
Auxiliary components are glycerol and propylene glycol.
Indication for the use of the drug "Candide"
The drug is used to treat lesions of the oral mucosa with candidal (fungal) stomatitis, provoked by yeast-like fungi of the genus Candida.
The drug in the most short time copes with colonies of the fungus, suppressing its development. It is noteworthy that "Candide" gives an excellent effect even with a significant weakening of the child's immune defenses. That is why the medicine is prescribed for diabetes and immunodeficiency states.
Contraindications to the use of Candide
When used topically, the drug is practically not absorbed by mucous membranes. That is why the tool can be safely used in children of all ages and babies are no exception.
The use of the drug should be abandoned if the child has an individual intolerance to the Candide component composition.
With caution, this medicine for stomatitis should be used in infancy. Since clotrimazole is a fairly active substance, it is highly recommended not to exceed the doses recommended by the pediatrician.
"Candide" for the oral cavity for children
The instruction contains the following instructions:
- processing should be carried out two to three times during the day;
- the duration of treatment is two weeks.
The dosage for adult patients is ten to twenty drops. For the treatment of thrush in children, the dosage is reduced by two to three times. But the pediatrician should select the exact rate of the drug for one treatment, taking into account the age of the child.
Improvements in the condition of the oral cavity in babies are fixed approximately on the third - fifth day from the start of treatment. It is not necessary to stop the course of treatment at this point. To consolidate the effect, therapy with Candide should be continued for up to ten full days.
The drug treatment scheme is as follows:
- Before applying the product, the oral cavity must be cleaned of white plaque. Here you can use soda solution. To prepare it, a spoonful of soda is dissolved in a glass of boiled water. Then the index finger should be wrapped with a sterile bandage and moistened in the prepared composition. After that, you need to carefully treat the inflamed mucosa.
- After that, the affected areas can be treated with Candide.
With thrush in infants, sanitation of the oral cavity with a soda solution is recommended up to five times a day, regardless of the use of Candide. Treatment with the drug can be performed only twice a day - in the morning and in the evening.
Dr. E. O. Komarovsky believes that any medication should be prescribed by a qualified specialist. Self-administration of drugs, especially in infancy, can cause various complications.
Side effects
Usually, adverse reactions when using the drug in children occur quite rarely. Reviews of mothers who practiced treatment with Candide confirm this.
The reaction to the drug can manifest itself in the form of:
- irritation of the mucous membranes after application of the agent;
- burning sensation;
- redness of the mucous membrane;
- the product has a rather unpleasant taste and, if it enters the throat, can provoke slight nausea.
If the child has the listed symptoms, then the treatment should be canceled.
Summary
The remedy may be part of complex therapy, but it must be remembered that Candide cannot be combined with the drug Nystatin, as well as medicines from the group of polyene drugs.
100 ml solution contains
active substance: clotrimazole 1.0 g,
excipient: propylene glycol.
Description
Clear, colorless, viscous liquid.
Pharmacotherapeutic group
Antifungal drugs for the treatment of skin diseases. Antifungal drugs for topical use. imidazole derivatives. Clotrimazole.
ATX code D01AC01
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Pharmacological properties
Pharmacokinetics
At topical application clotrimazole is poorly absorbed from the skin surface (accumulates in the stratum corneum of the epidermis). Bioavailability is less than 0.5%. Accumulates in the stratum corneum of the epidermis at a concentration higher than the minimum inhibitory concentration (MIC) for most pathogens
mushrooms (50 - 100 mcg / ml). The concentration in the basal layer of the epidermis is 1.53 - 3 μg / ml. Penetrates into nail keratin.
In the liver, it is biotransformed to inactive metabolites and excreted through the intestines. The proportion of renal excretion is 0.05% - 0.5%. The half-life of the parent substance is 3.5 - 5 hours.
Pharmacodynamics
Candide is a broad-spectrum antifungal agent for external use. The antimycotic effect of the active ingredient clotrimazole (imidazole derivative) is associated with a violation of the synthesis of ergosterol, which is part of the cell membrane of fungi, which changes the permeability of the membrane and causes subsequent cell lysis. In small concentrations, it acts fungistatically, and in large concentrations, it acts fungicidal, and not only on proliferating cells. In fungicidal concentrations, it interacts with mitochondrial peroxide enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells. It is effective against dermatophytes, yeast-like and mold fungi, as well as the causative agent of multi-colored lichen Pityriasis versicolor (Malassezia furfur) and the causative agent of erythrasma. It has an antimicrobial effect against gram-positive (staphylococci, streptococci) and gram-negative bacteria (Vasteroides, Gardnerella vaginalis), as well as against Trichomonus vaginalis.
Indications for use
Fungal diseases of the skin, mycoses of skin folds, feet
Pityriasis versicolor, erythrasma, superficial candidiasis caused by dermatophytes, yeasts (including the genus Candida), molds and other fungi and pathogens sensitive to clotrimazole
Mycoses complicated by secondary pyoderma
Dosage and administration
Outwardly. The solution is applied in a thin layer 2 times a day on pre-cleaned (using soap with a neutral pH value) and dried affected skin areas.
The duration of treatment depends on the severity of the disease, localization pathological changes and effectiveness of therapy. Treatment of ringworm is carried out for at least 4 weeks, pityriasis versicolor - 1-3 weeks.
In case of fungal diseases of the skin of the legs, it is recommended to continue therapy for at least 2 weeks after the symptoms of the disease have disappeared.
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Side effects
Candide solution is usually well tolerated.
Redness of the skin, burning sensation, tingling and irritation at the site of application of the drug
Erythema, urticaria, pruritus, blistering, edema, skin peeling
Contraindications
Hypersensitivity to clotrimazole and other components of the drug
I trimester of pregnancy.
With caution: lactation period.
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Drug Interactions
Clotrimazole reduces the activity of amphotericin B and other polyene antibiotics. With simultaneous use with natamycin and nystatin, the activity of clotrimazole may decrease. Propyl ester of parahydroxybenzoic acid in high concentrations enhances the antifungal effect of clotrimazole. Dexamethasone in high doses inhibits the antifungal action of clotrimazole.
special instructions
If signs of hypersensitivity or irritation appear, treatment should be discontinued. It is not recommended to wear clothes and shoes that do not allow moisture and heat to pass through. It is recommended to change clothes daily, wash at 90°C and use disposable towels.
In patients with hepatic insufficiency, the functional state of the liver should be periodically monitored.
If there is no effect within 4 weeks, the diagnosis should be confirmed.
For external use only.
Pregnancy and lactation
In clinical and experimental studies, it has not been established that the use of the drug during pregnancy or during lactation has a negative effect on the health of a woman or fetus (child). However, the question of the advisability of prescribing the drug in the II or III trimester should be decided individually after consultation with the doctor. When prescribing the drug during the II or III trimesters of pregnancy, the ratio of the expected benefit from prescribing the drug to the mother and the possible risk to the fetus should be taken into account.
The penetration of clotrimazole into breast milk not known. Caution should be exercised when prescribing clotrimazole to lactating women. Application of the drug in the area of the mammary gland is contraindicated.
Application in pediatrics
Children should be prescribed Candide solution only after consultation with a pediatrician, strictly according to indications.
Features of the effect of the drug on the ability to drive vehicle or potentially dangerous mechanisms
Does not affect driving or working with complex technical devices.
Human mucous membranes are constantly exposed to attacks of harmful microorganisms. Usually, the immune system copes with them, and no diseases occur. And what about those who have weakened immune systems up to the onset of infection? After all, if you do not proper treatment, then this will lead to many unpleasant and dangerous complications.
The most common infection is candidiasis.. Many leave it unattended, which leads to the growth of fungi on the surface of the mucous membranes. In this case, the antimycotic drug Candide is used. For the oral cavity and the treatment of other mucous membranes, it is very effective, and the treatment is easy and fairly fast. It is produced by the Indian company Glenmark Pharmaceuticals Ltd, which has been involved in the development of effective pharmaceuticals for many years.
Release form
Most often, the tool is used as viscous one percent solution. It is available in dropper bottles made of polyethylene. The bottles have a screw cap. Inside is the active substance clotrimazole. Auxiliary components include propylene glycol and glycerin. In addition, the drug can be bought in the form of vaginal tablets, powder, cream or gel: it all depends on the type of disease. For example, with female thrush, vaginal tablets, with oral candidiasis - a solution, for the treatment of an affected disease of the nasopharynx, a gel or solution is prescribed.
How the drug works
The drug Candide has a wide range of applications. It works in three directions: antiprotozoal, antimicrobial and antimycotic. This means that Candide can affect protozoa (Trichomonas, Giardia), inhibit the growth of harmful microorganisms in the intestines and stop the reproduction of yeast-like fungi.
What is a good antifungal effect? The active ingredient clotrimazole acts in such a way that ergosterol is a natural compound in various types fungi - ceases to form. But it enters the cell membrane of fungi, being its most important element, therefore, the cell dies.
Candide acts on both growing and dividing cells. and hinder their spread. Taking a small concentration of the drug leads to a fungistatic effect, and its further increase leads to a fungicidal one. The first effect is based on a decrease in the synthesis necessary to build fungal cells. The fungicidal effect stops the growth process of the fungus, and all the vital processes needed to build the cell stop. What happens as a result? Cells can neither divide nor develop, which means that the development of a fungal disease stops and the person recovers.
A brief introduction to Candida
Candida mushrooms are yeast-like, and their habitats include the intestines, vagina, nasopharynx and skin. At the same time, 85% of people do not develop diseases due to these fungi. They usually cause candidal stomatitis and thrush, especially when the person's immune status is reduced. It is worth paying attention to the fact that such fungi are found in the microflora of each person, but with a greatly weakened immune system, fungi begin to multiply uncontrollably.
In a sick person, the oral cavity or genitals are covered with a white coating, causing irritation, itching and pain. Therefore, after treatment with strong antibiotics, doctors often warn of the possible occurrence of thrush and prescribe antifungal drugs, even just in case.
For what diseases is Candide prescribed?
As already mentioned above, Candide can be applied in different areas related to fungi. For example, they treat patients suffering from the following diseases:
- vaginal trichomonas;
- thrush;
- candidiasis stomatitis;
- pityriasis versicolor;
- multi-colored lichen.
In addition, the drug is prescribed to suppress the growth of gram-negative bacteria. These include gardnerella, bacteroids and vaginalis. And also Candide is effective against yeast-like and mold fungi of the genus Candida, dermatomycetes, flaky epidermophilus, red trichophyton.
Instructions for use
Since the drug is available in a variety of forms, application will vary. For example, a solution of Candide for the oral cavity is applied to the tip of a cotton swab, after which all the affected mucous membranes are gently blotted. Such procedures should be carried out 3-4 times a day. If a person has a mycotic skin disease, the doctor prescribes Candide ointment. It should be rubbed into the affected areas of the skin 2 times a day.
For children, the company specially produces Candide cream, intended for the treatment of stomatitis. It is used in the same way as the solution. For women, vaginal tablets are used: they are used both as a sanitation before childbirth, and as a treatment for vaginal candidiasis. Moreover, the treatment has a feature: 1 tablet (500 mg) is administered intravaginally only once, but treatment with other forms of the drug is carried out for a week or more until complete recovery.
How to treat a child: features
The child has a thin and delicate mucous membrane: she is extremely receptive to any action. Therefore, any rubbing of the ointment, gel or solution of Candide should be done with light gentle movements, otherwise the course of the disease will only worsen.
As for newborns, they may have an allergic reaction to clotrimazole. There may be swelling and redness of the mucosa. If the drug accidentally enters the gastrointestinal tract of a child, then due to imperfect bowel function, bloating, diarrhea and vomiting are possible. This can be avoided if the drug is used carefully: blot a piece of sterile bandage in the Candide solution and gently treat the areas. And for the treatment of fungal skin diseases, it is better to use the product in the form of a powder. The affected areas are sprinkled with a thin layer 2 times a day until recovery.
Application for pregnant women
In the first trimester of pregnancy, the fetus is not yet sufficiently protected by the placenta. Therefore, with such a period, Candide is not prescribed. At breastfeeding admission is limited and correct dosage determined by the attending physician.
Candida from stomatitis
The drug is effectively used in the following forms of stomatitis:
Side effects
They usually appear as:
- allergies arising as a result of individual intolerance;
- gastrointestinal disorders (nausea, vomiting, diarrhea);
- itching and burning, which then disappear.
3D images
Composition
Description of the dosage form
Colorless, transparent, viscous liquid.
pharmachologic effect
pharmachologic effect- broad spectrum antifungal.Pharmacodynamics
Clotrimazole is an imidazole derivative, a broad-spectrum antifungal agent.
The antimycotic effect is associated with a violation of the synthesis of ergosterol, which is part of the cell membrane of fungi, which causes a change in its structure and properties and leads to cell lysis.
Dermatophytes, yeast-like fungi (genus Candida, Torulopsis glabrata, Rhodotorula), mold fungi, as well as the causative agent of multi-colored lichen Pityriasis versicolor and the causative agent of erythrasma.
It has an antimicrobial effect against gram-positive (staphylococci and streptococci) and gram-negative bacteria ( Bacteroides, Gardnerella vaginalis), as well as with regard to Trichomonas vaginalis.
Pharmacokinetics
When applied topically, the adsorption of clotrimazole from the mucous membranes is negligible.
Indications for Candide
Candidal stomatitis.
Contraindications
Hypersensitivity to the components of the drug.
Use during pregnancy and lactation
The use of the drug during pregnancy or lactation is allowed in cases where the intended benefit to the mother outweighs the risk to the fetus or infant.
Side effects
The drug is usually well tolerated. IN rare cases, with hypersensitivity to the components of the drug, allergic reactions are noted - redness of the oral mucosa, burning sensation and tingling at the site of application of the drug, urticaria.
If irritation occurs, the drug must be discontinued.
Interaction
With simultaneous use with amphotericin B, nystatin, the activity of clotrimazole may decrease.
Dosage and administration
locally, 10-20 drops (1/2-1 ml) are applied to the affected areas of the oral cavity with a cotton swab 3-4 times a day. Improvement usually occurs on the 3-5th day of treatment, however, treatment should be continued until complete elimination. clinical manifestations diseases.
Overdose
There are various microorganisms in the oral cavity, some of them potentially harmful. The fungus of the Candida type in its normal state is dormant and does not pose a danger. As soon as the immune system is weakened or other favorable conditions arise, the fungus begins to actively multiply. Without timely treatment, it will spread throughout the mucosa and can cause serious complications. The oral candida preparation helps to overcome the symptoms and causes of the disease in children and adults.
Candide - antifungal medicine, the active substance is clotrimazole, a derivative of imidazole. It is mainly produced in the form of suppositories, gel and solution. Candida solution is used for rinsing and is found in our market in small 15 ml bottles. Externally, the substance is transparent and viscous. 1 ml contains 10 mg of clotrimazole, additional substances - glycerol and propylene glycol. When used, there is a local antimycotic, antiprotozoal, antimicrobial effect.
When in contact with the fungus, clotrimazole disrupts the production of ergosterol, which is a key part of the fungal cell membrane. The death of bacteria occurs due to a change in their permeability - it becomes too vulnerable to external factors. At low concentrations, the active substance has a fungistatic effect, while at high concentrations it has a fungicidal effect.
It mainly affects growing and dividing cells. Developed microorganisms have increased resistance, therefore, in large doses, clotrimazole directly affects the peroxidase and mitochondrial enzymes. This leads to the creation of hydrogen peroxide, which destroys bacterial cells.
Most effective against:
- yeast-like and mold fungus;
- gram-positive bacteria;
- dermatomycetes;
- multicolored and pityriasis versicolor;
- gram-negative bacteria;
- the causative agent of trichomoniasis.
It is extremely rare to find clotrimazole-resistant fungi, so treatment is effective in most cases. But if the fungus is not cured, it can return with acquired resistance. The strain of Candida guillermondii may not respond to treatment, in which case you should increase the dosage or choose a different medicine. Local application of clotrimazole leads to its absorption through the mucous membrane, there is no referential effect.
Application of the product
Candide is a solution for the oral cavity, the instructions are quite simple. Like any other medicine, it must be used after a doctor's prescription. Basically, it is discharged for stomatitis in children after examination and complete testing. Still, Candida is a narrowly targeted drug that copes well with fungal pathogens. The main advantage is a local effect, the components of the drug do not enter the child's blood. This is doubly important in the treatment of newborns.
The oral cavity should be treated 2-3 times a day. It is necessary to continue the procedure for two weeks. Dosage for adults 15-30 drops. It is advisable to choose a dose for children by a therapist, basically it is 2-3 times less. Positive results should appear in 3-5 days. To consolidate the treatment, regular intake cannot be interrupted, the course should be at least ten days. This is done to completely destroy the pathogen in oral cavity- the surviving fungus is able to return in the future with acquired resistance to treatment.
Before applying the solution, the affected area should be cleaned of fungal plaque. From improvised means, a soda solution is best suited: 1 teaspoon of soda per 1 glass of water, after mixing, wrap a bandage on one finger, moisten it in the resulting solution and gently clean the mucous membrane. Do not apply pressure, otherwise you risk causing irritation and even damage. It is advisable to clean the mucosa up to 5 times a day, while Candida itself with stomatitis is applied no more than twice a day after meals.
For more effective treatment it is advisable to go on a diet. Remove from the diet: sugar, milk, yeast bread, honey and confectionery. Limit the intake of dairy products (cottage cheese, kefir). Increase the amount of protein foods: eggs, legumes, meat, fish. Also include in the diet more fruits and vegetables, and it is desirable to turn them into a mushy state before use. If the child is breastfed, the diet must be followed by the mother.
Side effects and contraindications
The main contraindication is individual intolerance to clotrimazole. Therefore, it is important to consult a specialist before taking it. Be especially careful if you are pregnant or breastfeeding. Candida from stomatitis is allowed for use during pregnancy and lactation only in cases where the benefit to the mother is more important than the harm to the child. There is no reliable data on whether the active substance enters the child during gestation or feeding, but it's still not worth the risk.
The drug is well tolerated by most people. In case of intolerance, reddening of the mucous membrane, tingling, burning, blistering and the development of urticaria at the application sites occur.
Adhering to the instructions for use, it is impossible to get an overdose, especially with topical use. With a significant ingestion, which is absolutely impossible to do, liver dysfunction, dyspeptic disorders, drowsiness, skin allergy, stomach pains, tamuria, hallucinations. When taken with other drugs against fungi, the overall effectiveness is reduced. Candide does not cause drowsiness and mental retardation.
It is worth remembering how to avoid candidiasis among children. First of all, it is necessary to strengthen the immune system, and the smaller the child, the worse his body is protected. While the newborn is breastfeeding, his mother should especially take care of her health - both beneficial substances and sores are transmitted through milk. If a mother is ill, she should stop breastfeeding her child until the illness is over. Your baby's nipples, bottles and toys should be cleaned at all times. The main carriers of Candida are adults, so they should limit their contact with children.