Tizalud - instructions, indications, composition, method of application. The use of muscle relaxant Tizalud: indications, instructions, reviews

Some facts about the product:

Instructions for use

Price in the online pharmacy site: from 143

Some facts

Targeted muscle relaxant. It has a positive effect on the quality and speed of muscle contractions. It is a moderate analgesic, which is important for the treatment of seizures, spasmodic syndromes. Relieves pain, eliminates the effects of neurological diseases, including stroke and multiple sclerosis.

The drug is used for the prevention of disorders, sclerotic nature, functional disorders of the brain, spinal cord.

Pharmacological properties

Tizalud belongs to the group of muscle relaxants, which are characterized by a pronounced centralized action. The active ingredients stimulate alpha-2 receptors of presynaptic origin, which slows down the release of aspartic and glutamic acids. These substances directly stimulate the corresponding receptors, which inhibits the polysynaptic transmission of excitatory impulses.

Thanks to this phenomenon, a qualitative, gradual relaxation of the skeletal muscles occurs. In addition to the analgesic effect, indications for partial inhibition of the functional features of the intercalary neurons in the region of the posterior processes (horns) of the spinal cord were recorded.

During the treatment of multiple sclerosis, the overall resistance to movement, of a passive nature, decreases. As a result, the effects of convulsions and spasms are mitigated. The patient's capabilities are increased in terms of the "mechanics" of movement. The quality of voluntary muscle contraction improves, regardless of concomitant diseases.

Tizalud does not affect the processes of a neuromuscular nature, including the direct transmission of excitation signals. The rate of assimilation, absorption of active substances depends on the dosage and pharmacokinetic characteristics of the drug.

The individual breadth of drug parameters, in terms of pharmacokinetics, is low. The peak concentration of the active substance in the blood plasma occurs 2 hours after a single dose. There is a pronounced effect after the first use, which increases the overall bioavailability of the drug up to 34%.

The effect of active components on plasma proteins of the blood is moderate. The level of binding to protein structures does not exceed 30%. Excretion from the body occurs in the form of inactive metabolites. A larger amount is formed and stored in the liver.

The amount of metabolites passing through the hematoembryonic barrier is small. A small dose of the substance, in unchanged form, is stored in breast milk. The agent acts on the central nervous system 45 minutes after the first dose. The permanent effect of Thezalud lasts for two hours.

Composition and form of release

The drug is sold in the form of round tablets. Supplied in a blister in a standard dose of 2 mg, 10 pieces per plate. Sold in cardboard boxes. The instruction is attached. The active ingredient is tizanidine. Microcrystalline cellulose, magnesium stearate, lactose of anhydrous origin are used as additional components ( possible contraindications in this substance).

Indications for use

Tizalud is used to treat the following pathologies:

• spastic complications during multiple sclerosis (individual dosage is relevant);
• skeletal muscle spasms of undetectable etiology;
• large-scale lesions of the brain, spinal cord.

Side effects

With prolonged therapy, aggressive reactions from the side are possible. of cardio-vascular system, including a sharp decline blood pressure, collapses of various origins, bradycardia.

Reception of Tizalud calls for weakness in the body, certain muscle groups, slight dizziness. V rare cases symptoms of hepatitis, liver failure. During regular use of the medicine, it is possible serious violations cerebral circulation.

Abrupt withdrawal of the drug significantly increases blood pressure. The composition is taken under the strict supervision of the attending physician. In specific cases, observation in a hospital setting is recommended.

Contraindications

Tizalud tablets are not used for severe functional disorders of the liver, individual hypersensitivity to active ingredients and lactose.

Application during pregnancy

Pregnancy in the 1-3 trimesters is a reason for limiting the intake, and not the complete abolition of this drug. The tool is prescribed solely on the recommendation of a narrow specialist. The ratio of actual benefit and harm to the fetus and the mother's body is taken into account.

Method and features of application

Thyzalud tablets are prescribed for adults, two units (2 or 4 mg) three times a day. In case of complications, one more dose is added, in the late afternoon. The medicine is washed down with clean water, you can use juice or tea. An exception is dairy, sour-milk products, especially for patients suffering from hypersensitivity to lactose and concomitant diseases.

According to the instructions for use, the maximum concentration of the active substance should not exceed 36 mg per day. People suffering kidney failure, appoint 2 mg of the drug once a day.

Overdose

Such complications are accompanied by vomiting, drowsiness, short-term loss of consciousness, dizziness, accompanied by nausea. The elimination of these symptoms begins with cleansing procedures, including gastric lavage, absorption of absorbents, diuresis.

Dosage form:   tablets Ingredients:

Active substance: Tizanidine hydrochloride - 2.288 mg and 4.576 mg in terms of tizanidine - 2.0 mg and 4.0 mg;

Excipients:

[Lactose anhydrous (lactopress)

117.012 mg and 234.024 mg, Microcrystalline cellulose 14.0 mg and 28.0 mg, Sodium carboxymethyl starch

(primogel) 4.2 mg and 8.4 mg, magnesium stearate 2.5 mg and 5.0 mg].

Tablet weight 140.0 mg and 280.0 mg.

Description:

Tablets are white or white with a yellowish tint, round, biconvex with a score.

Pharmacotherapeutic group:Centrally acting muscle relaxant ATX:  

M.03.B.X Other centrally acting muscle relaxants

M.03.B.X.02 Tizanidine

Pharmacodynamics:

Muscle relaxant of central action. The main point of application is in the spinal cord. By stimulating presynaptic alpha2-adrenergic receptors, it inhibits the release of excitatory amino acids from intermediate neurons of the spinal cord, which leads to inhibition of polysynaptic transmission of excitation in the spinal cord. As a result, there is a decrease in muscle tone. In addition to muscle relaxant properties, it also has a central, moderately pronounced analgesic effect.

Effective against acute painful muscle spasms and chronic spasms of spinal and cerebral origin. Reduces spasticity and clonic convulsions, as a result of which resistance to passive movements decreases and the volume of active movements increases.

Pharmacokinetics:

Absorption - high; the time to reach the maximum plasma concentration (Cmax) - 1-2 hours. Bioavailability - 34%. Eating does not affect the pharmacology of coca neti ku. The volume of distribution is 2.6 l / kg. Communication with plasma proteins - 30%. In the dose range from 4 to 20 mg, the pharmacokinetics is linear. Metabolized rapidly and largely in the liver (95%) with the formation of inactive metabolites. The half-life (T1 / 2) is 2-4 hours. It is excreted mainly by the kidneys (70% of the dose in the form of metabolites, 2.7% unchanged). In patients with renal insufficiency (CC less than 25 ml / min), the maximum plasma concentration (Cmax) increases by 2 times, T1 / 2 - 14 hours, the area according to the pharmacokinetic curve "concentration-time" (AUC) increases by 6 times.

Indications:

painful muscle spasm associated with static and

functional diseases of the spine (cervical and lumbar syndromes), as well as after surgical interventions (for example, for a herniated disc or osteoarthritis hip joint);

spasticity of skeletal muscles in neurological diseases (for example, with multiple sclerosis, chronic myelopagia, degenerative diseases of the spinal cord, the consequences of cerebrovascular accident, as well as in cerebral palsy / patients over 18 years of age /).

Contraindications:

Severe liver dysfunction;

Hypersensitivity to tizanidine, other components of the drug;

Rare hereditary lactose intolerance, severe lactase deficiency, glucose-galactose malabsorption (for this dosage form containing lactose);

The use of tizanidine in children (under 18 years of age) is not recommended, because. experience with the drug in this category of patients is limited.

Carefully:

renal failure, arterial hypotension,

bradycardia, simultaneous use of oral contraceptives, age over 65 years

Pregnancy and lactation:

Since no controlled studies have been conducted on the use of tizanidine in pregnant women, it should not be used during pregnancy unless the expected benefit to the mother outweighs the possible risk to the fetus.

Tizanidin is excreted in breast milk in small amounts. However, if it is necessary to use tizanidine during lactation, the issue of discontinuation should be considered. breastfeeding.

Dosage and administration:

Relief of painful muscle spasm: inside, 2-4 mg 3 times a day, in severe cases - additionally 2-4 mg at night.

Treatment of spasticity due to neurological diseases: the initial dose is 2 mg 3 times a day, then the dose is gradually increased by 2-4 mg at intervals of 3-7 days. The optimal daily dose is 12-24 mg in 3-4 doses; the maximum daily dose is 36 mg.

it is necessary to obtain a more pronounced effect, it is recommended to first increase the dose prescribed 1 time per day, then increase the frequency of administration.

Side effects:

From the nervous system: drowsiness, dizziness, hallucinations, insomnia, sleep disturbances.

Since the cardiovascular system: bradycardia, lowering blood pressure (in some cases, pronounced, up to collapse and loss of consciousness).

From the side digestive system: dry mouth, nausea, dyspepsia, increased activity of "liver" transaminases, hepatitis, liver failure.

From the musculoskeletal system: muscle weakness.

Others: fatigue, hypercreatininemia.

With abrupt cancellation after prolonged treatment and / or taking high doses of the drug (as well as after simultaneous use with antihypertensive drugs): tachycardia, increased blood pressure, in some cases - acute cerebrovascular accident.

Overdose:

Symptoms: nausea, vomiting, pronounced decrease in blood pressure, dizziness,

drowsiness, miosis, anxiety, respiratory failure, coma.

Treatment: gastric lavage, administration of activated charcoal, forced diuresis, symptomatic therapy.

Interaction:

The simultaneous use of tizanidine with fluvoxamine or ciprofloxacin, inhibitors of cytochrome P450 isofermeite 1A2, leads to a 33-fold increase in the AUC of tizanidine. The result of combined use may be a clinically significant and prolonged decrease in blood pressure, leading to drowsiness, weakness, inhibited psychomotor reactions (in some cases, up to collapse and loss of consciousness).

Antihypertensive drugs (PM) increase the risk of a pronounced decrease in blood pressure and bradycardia.

Ethanol, sedative drugs can enhance the sedative effect of tizanidine, therefore, simultaneous use with other sedative drugs and / or alcohol is not recommended.

Special instructions:

It is recommended to monitor liver function once a month for the first 4 months of treatment, in those patients who are prescribed daily dose 12 mg and above, as well as in cases where clinical signs are observed that suggest a violation of liver function, such as unexplained nausea, anorexia, fatigue. In the case when the activity of aspartate aminotransferase (ACT) and alanine aminotransferase (ALT) persistently exceeds upper bound the norm is 3 times or more, tizanidine is stopped.

Patients with a syndrome of congenital prolongation of the QT interval should be administered with caution, because. in preclinical studies of chronic toxicity in animals (dogs), prolongation of the Q-T interval was noted when using the drug at a dose equivalent to the maximum human dose. Due to the threat of a "withdrawal" syndrome, the dose of tizanidine is reduced gradually.

Influence on the ability to drive transport. cf. and fur.:

During treatment, care should be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Thezalud - medicinal product from the group of muscle relaxants of the central action, which is used to eliminate painful muscle spasms.

Release form, composition

Tizalud is available in the form of tablets for oral administration. Tizanidine is used as the active ingredient. The drug is available in 2 and 4 mg, 30 pcs. packaged.

pharmachologic effect

Under the influence of the drug Tizalud, there is a decrease in the increased tone of skeletal muscles and the elimination of their spasm, as well as the normalization of muscle resistance during passive motor activity. Tablets increase the strength of arbitrary contractions. The muscle-relaxing effect of Tizalud is due to its ability to inhibit the spinal polysynaptic reflex. The drug does not affect the transmission of excitations in the area of ​​neuromuscular synapses.

The use of Tizalud demonstrates effectiveness both in acute painful muscle spasms and in chronic spasticity of spinal and cerebral origin. The drug helps to reduce seizures, reduce resistance to passive movements and increase the volume of active movements.

The absorption of the active ingredient is carried out quickly, the maximum concentration is reached 60 minutes after taking the tablet. The average half-life is up to 4 hours.

Indications

Tizalud can be used as part of complex therapy the following diseases and states:

• spasticity due to multiple sclerosis;
• spasticity due to lesions of the spinal cord;
• spasticity due to brain damage.

The drug is used to eliminate painful muscle spasms caused by:

• diseases affecting the spine: the development of cervical and lumbar syndrome;
• surgical interventions, including herniated discs and osteoarthritis of the hip joints.

Mode of application

Tizalud tablets are intended for internal use. The exact dosage and duration of the drug is determined on an individual basis. It is allowed to gradually increase the dosage under the supervision and on the recommendation of a doctor. In this case, it is necessary to observe an interval of 3 days to 1 week.

Contraindications

Tizalud is not used for individual intolerance to the active or auxiliary components of the drug, as well as for severe liver dysfunction, during pregnancy and breastfeeding. If it is necessary to use the drug during the treatment of a nursing woman, it is necessary to consider the issue of stopping lactation.

The use of the drug is contraindicated simultaneously with drugs based on ciprofloxacin and fluvoxamine.

Particular caution is required when using the drug in the treatment of patients with impaired liver and kidney function. It is also necessary to be especially careful when using Tizalud during the treatment of patients of older age groups, since there is not enough clinical experience on the use of the drug in this category of people.

Adverse reactions

Tizalud can contribute to the development of unwanted side reactions in the form of:

• nausea, hepatitis, dyspepsia, liver failure, increased activity of hepatic transaminases;
• increased fatigue, skin itching, urticaria, hyperkeratinemia;
• weakness in the muscles;
• drowsiness, weakness, hallucinations, hearing impairment, dizziness, sleep disturbances, dry mouth;
• bradycardia, decreased blood pressure, impaired consciousness.

In the event that the use of Tizalud is abruptly canceled after prolonged use, tachycardia may develop, and blood pressure rises. In some cases, cerebrovascular accidents may occur.

In case of an overdose, adverse reactions may occur in the form of nausea, vomiting, arterial hypotension, dizziness, miosis, anxiety, coma, and respiratory disorders. As a treatment, it is necessary to cancel the use of the drug, wash the stomach, take activated charcoal repeatedly. In the future, it is necessary to consult a doctor for the appointment of a drug for symptomatic treatment. There is no specific antidote, forced diuresis may be indicated.

drug interaction

Against the background of the use of Tizalud, you should not drink alcohol, as this may enhance the sedative effect of the drug.

With the simultaneous use of Tizalud with drugs from the group of diuretics and antihypertensive drugs, it may develop arterial hypertension or bradycardia.

There may be an increase in the sedative effect of Tizalud in the case of simultaneous use with sedative drugs.

At the beginning of treatment with Tizalud, reactions may occur in the form of a feeling of drowsiness, so at this stage it is worth refraining from performing work that requires increased attention and driving.

One of the components of the drug is lactose, so it is recommended to refrain from using tablets in patients with a history of hereditary galactose intolerance, severe lactase deficiency and glucose malabsorption.

Storage of the drug is carried out in a dark, dry place in compliance with the temperature regime: no more than 25 degrees.

Analogues, cost

The cost of the drug Tizalud for the period June 2017 was formed as follows:

• Tablets 2 mg, 30 pcs. - 140-145 rubles.
• Tablets 4 mg, 30 pcs. - 200-210 rubles.

Analogues of the drug Tizalud are: Tizanil, Sirdalud, Tizanidin-Teva. If you need to select a replacement, you must first consult with your doctor.

Reviews

“Thizalud was prescribed by a doctor composed of complex treatment osteochondrosis. Additionally, they used B vitamins, NSAID painkillers for internal use and external application, and, of course, muscle relaxants like Tizalud will help with muscle spasms. If the pain syndrome was mild or moderate, I used the lowest effective dose recommended by the doctor. I tried to take a pill before going to bed, because the drug can cause drowsiness. Under the influence of the pill, all muscles smoothly relax, the body falls into sleep. In addition to drowsiness, there were no other adverse reactions, the drug did not cause addiction either.

Olga

“Tizalud was encountered when the drug was prescribed by a doctor for the treatment of pain in the spine. The tablets act quickly: they help to cope with pain, and there were no side effects. The treatment itself took place in stationary conditions, under the constant supervision of doctors. You should not use these pills on your own. The drug has contraindications, tablets are available in several dosages. Only a doctor will be able to accurately select a treatment regimen and determine which additional drugs should be used.

Nina

« Tizalud well helps to cope with various neurological diseases, pains accompanying osteochondrosis, various painful spasms. The tablet is well tolerated and what is important in my case - it does not have an unpleasant taste. I simply could not take other drugs from the group of muscle relaxants because of the terrible taste - I know that such a reaction is very individual. During the treatment, there were also all kinds of side effects in the form of nausea, drowsiness, dizziness, general weakness in the body. The drug, of course, is effective, but using such strong means better only under the supervision of a doctor.

Julia

“Faced with the fact that the reason severe pain even a stressful situation can become in the back. No painkillers, even the strongest, did not bring the desired effect. The pain was so intense that I couldn't bend down to put on my shoes. I used medicines for internal use, as well as external creams, gels and ointments - no result. I went to the pharmacy, described the problem, where I was advised to try taking Tizalud. Of course, the drug did not work instantly, but there was a noticeable relief immediately. In addition, I used various anti-stress drugs. Back pain was relieved approximately 2 weeks after the start of such treatment. I note right away that it is better to take Tizalud at night, since the remedy is strong and can cause drowsiness.

Natalia

I faced the problem of osteochondrosis for a long time, the last attack was so strong that I had to consult a neurologist. The doctor listened to the complaints and prescribed Tizalud. I had not taken such a drug before, it turned out that it is a muscle relaxant that helps to cope with pain. The doctor strongly recommended taking the drug once a day - before going to bed, and I do it. The tablet is medium in size and easy to swallow. Sleep after taking comes very quickly. Back pain is gone, sleep is back to normal. Side effects during the reception did not occur, many note severe weakness and drowsiness, but this is easily prevented if the drug is used at night. I met reviews that the drug can cause withdrawal syndrome, but I do not observe such a side effect. The cost of tablets is quite budgetary - at the time of purchase, 200 rubles. for 30 pcs. 4 mg. The drug proved to be effective, but it should be taken only under the supervision of a doctor.

Tizalud has an analgesic effect, is able to reduce the intensity of spasms, clonic convulsions and increase the intensity of voluntary contractions. The drug belongs to the group. Prescribe medication for.

The principle of operation affects presynaptic receptors, which reduces the degree of excitation of amino acids that affect the M-methyl-B-aspartate receptors. As a result, at the level of neurons of the spinal cord, polysynaptic reactions are extinguished.

The composition of the drug and the form of release

1 capsule contains:

• 2 mg tizanidine (as hydrochloride) - the main active ingredient;
• stearic acid;
• cellulose;
• lactose anhydrous.

The blister contains 10 tablets, in one box - 3 blisters.

Pharmacological influence and pharmacokinetics

The drug is able to cause a weak analgesic effect caused by inhibition of the neurons of the posterior parts of the spinal cord.

Also, the drug reduces resistance during passive movements, softens spasmodic reflexes and convulsions of the clonic type.

The intensity of voluntary reflexes also increases. There is no interaction with neuromuscular transmission.

Tizanidin - the main active ingredient of Tizalud, is very quickly absorbed by the body. Within an hour, its concentration in the blood plasma reaches its maximum value.

At the same time, bioavailability matters - 34%.

The substance is 30% bound to plasma protein. The deviation of pharmaceutical parameters is very low: (Cmax and AUC), because of this, it is possible to reliably estimate the concentration of the drug in the blood plasma orally.

Who is prescribed the drug

The drug is prescribed to adult patients suffering from diseases of the neuromuscular system, they attribute: 2-4 mg three times a day. If the patient is experiencing a particularly severe form of the disease, it can be used as a supplement at bedtime - 2 or 4 mg.

Indications for the use of Tizalud:

Important! During the time manifested due to diseases of a neurological nature, the dose of the drug must be chosen separately in each individual case.

Contraindications for use

In the following cases, the use of the drug is not recommended:

• hypersensitivity to one of active substances medication;
• acute disorders in the liver;
• co-administration of ciprofloxacin with fluvoxamine.

More detailed information about contraindications to Tizalud is in the official instructions, which comes with the drug.

Tactics and strategy of therapy

Persons who have reached the age of majority take the drug orally, regardless of when the food is taken, the medicine is washed down with water.

The mode of use and dosage is prescribed by the doctor, taking into account the individual characteristics of the patient and such points as allergic reactions and age. Maximum total daily rate taking the drug for adults - 36 mg per day.

For people who suffer from acute renal failure, doses must be reduced, for them the daily norm will be already - 2 mg 1 time per day.

Increase the dose slowly, taking into account how effective the medicine is and how the body reacts to it. To obtain a more pronounced effect, initially increase the dosage of the drug, and only then the frequency of taking per day.

Cases of overdose

An overdose of the drug has not yet been properly studied, so it is impossible to talk about the consequences for sure. In isolated cases, the following symptoms were noticed:

• drowsiness;
• nausea;
• anxiety;
• vomiting attacks;
• arterial hypotension;
• distress;
• bradycardia;
• miosis;
• prolongation of the QT interval;
• dizziness;
• coma.

In cases of overdose, first of all, the stomach is washed many times with activated charcoal solutions. Forced diuresis is carried out, it helps in the speedy removal of drug residues from the body. Further treatment is carried out according to the symptoms.

Possible problems with admission

When taking the drug, the following side effects were noticed:

• serum transaminases;
• predisposition to sleep;
• dysfunction in the digestive system;
• excessive fatigue;
• low pressure;
• attacks;
• dry mouth.

Symptoms are most often mild and only visible in patients using Tizalud to combat muscle spasm.

In those people who take a large dosage for the purpose of treatment, the symptoms of side effects appear much brighter and more often, but usually they never cause concern, they are considered a normal, concomitant phenomenon and the treatment is not stopped.

There are also such side effects: arterial hypotension, bradycardia, muscle weakness, poor sleep, attacks of hallucinations and even hepatitis.

special instructions

The drug may affect the ability to drive or use machines normally. When the central nervous system begins to experience side effects as a result of the action of the drug (a person wants to sleep, etc.), the patient needs to abandon such work that requires increased attention or reaction.

For example, driving various vehicles or other mechanisms. If, when taking the drug, the symptoms of side effects do not go away for a long time, or even worse, they increase, you need to contact your doctor for advice.

When side effects appear, it may be due to liver weakness (sudden nausea, fatigue, etc.) and in people who use more than 12 mg of tizanidine per day. In such cases, it is necessary to control the liver, through special analyzes(samples) monthly, in the first half of the treatment.

If the amount of liver transaminases exceeds the prescribed level three times, the drug should be stopped immediately.

For those who have kidney dysfunction, no more than 2 mg per day can be prescribed. Then there is a very careful increase in the dose, at this time the patient is under the constant supervision of a doctor. Initially, the amount of the drug taken per day rises, only then the number of doses.

Interaction with other drugs

If, besides Thezalud, any other medicine, before taking them together, be sure to consult a doctor about this possibility. It is strictly forbidden to take tizanidine and fluvoxamine inhibitor at the same time.

It is also necessary with extreme caution to take the drug with such drugs, due to which the QT interval increases. And the combined use of tizanidine with alcohol will increase its effect on the body.

Reception during pregnancy and lactation

There is very little information that explains the effect of the drug on pregnant women, so it is not prescribed during the period pregnancy.

There are exceptions when the drug is still prescribed, in cases where its benefit is more important for the life of the mother than the potential risk to the unborn child.

It is known that the active substance tizanidine in a small amount enters the mother's milk. That is why, for women who feed the baby with their milk, the medicine is also not prescribed.

There is no information yet about the effect of the drug on the child's and adolescent body. Therefore, they are not prescribed medicine.

From the practice of patients

Tizalud tablets have found their admirers among patients, which is confirmed by numerous reviews on the network.

The drug began to be taken after the cramps in the feet began to disturb. There were no prerequisites for this, no injuries or anything like that, probably just age.

As a result, after consulting with a doctor, I received a prescription for Tizalud. The complex of treatment lasted two months, although after the first two weeks the symptoms disappeared. After a while, I plan to drink the drug again for prevention purposes.

Oksana Dmitrievna, 62 years old, Irkutsk

It was, as a result, an artery was interrupted and the blood supply to the brain was disrupted, there were a lot of negative symptoms, a real nightmare.

A number of drugs for healing and restoration of function were prescribed in the district hospital circulatory system and the brain, but after a long-term use, I did not see any positive sensations, except for side effects. Now I'm trying this drug. I will definitely write about the results.

Ivan 44 years old, Tver

My husband and I got into a car accident, as a result of a head injury. I was sick for half a year just every day, I could neither work nor sleep normally.

Tizalud helped almost immediately, after a month of taking everything fell into place.

Alisa 19 years old, Syktyvkar

Terms and conditions of storage

The medicine should be stored in its original box at a temperature of 15-25 °C. In a place inaccessible to sunlight and children. The shelf life of the drug is three years.

There are Tizalud analogues on the market with similar characteristics:

What is the drug "Tizalud"? Instructions for use, reviews and features of this medication will be discussed below. You will also learn about whether the remedy in question has side effects and prohibitions on use.

Form, packaging of the drug, composition

In what form is the drug "Tizalud" produced? Patient reviews report that this medication is sold in tablet form, which may include 4 or 2 mg of the active ingredient tizanidine.

In addition to the mentioned substance, the composition of the drug in question includes such additional elements as anhydrous lactose, sodium carboxymethyl starch, magnesium stearate and microcrystalline cellulose.

Tablets "Tizalud", reviews of which are presented below, are packed in contour cells, which are placed in cardboard boxes.

Pharmacology of the oral remedy

What is remarkable about such a drug as "Tizalud"? Instructions, reviews of experts indicate that this remedy is a muscle relaxant that exhibits a central effect.

What changes occur in the human body after taking the drug in question? The effect of its active component on alpha2-adrenergic receptors (presynaptic) contributes to the inhibition of the release of excitatory amino acids from the intermediate spinal neurons, which ultimately leads to a slow polysynaptic propagation of the impulse in the spinal cord. Due to this mechanism of action, muscle tissue the patient is significantly reduced.

Features of the drug

What other properties are characteristic of the drug "Tizalud"? The reviews claim that, in addition to the muscle relaxant effect, tizanidine has a moderate analgesic effect.

According to the instructions, these tablets are very effective for chronic spasms of spinal and cerebral origin, as well as painful and acute spasms of muscle tissue.

Taking this medication significantly reduces muscle spasticity and clonic convulsions, resulting in reduced resistance to passive movements, and also increases the likelihood of active actions.

Indications for taking medication

Under what conditions of the patient does such a remedy as "Tizalud" work most effectively? Reviews of the drug indicate that this medication quite well and quickly eliminates muscle spasms that are observed in pathologies of the spinal column and are accompanied by pain. Thus, the agent in question is often prescribed for:

• spondylosis;
• hemiplegia;
• osteochondrosis;
• syringomyelia;
• lumbar and cervical syndromes.

Are there any other indications for the drug "Tizalud"? Reviews of experts say that this remedy is actively used in the postoperative period after intervention for intervertebral hernias and osteoarthritis of the femoral joint. Also, the tablets in question help well with pain and spasticity of muscles provoked by neurological diseases, including chronic myelopathy, cerebral palsy, degenerative changes in the spinal cord, convulsions of central origin, cerebrovascular accidents, multiple sclerosis, stroke, injuries of the skull and brain.

Prohibitions on the use of oral medication

What contraindications should patients be aware of before taking Tizalud tablets? Instructions, reviews report that there are not very many prohibitions on the use of this medicine. These include only the following conditions:

• hypersensitivity of the patient to tizanidine, as well as other constituent elements of the drug;
• concurrent use of drugs such as Ciprofloxacin and Fluvoxamine, as well as other potent inhibitors of the CYP1A2 isoenzyme.
• liver pathology (severe);
• period of gestation;
• minor age;
• breastfeeding period.

Cautious drug prescribing

With caution, the medication in question should be prescribed in the following cases:

• with renal failure;
• over the age of 65-68 years;
• with bradycardia;
• with arterial hypotension;
• when used together with oral contraceptives.

The drug "Tizalud" (tablets): instructions for use

Reviews of doctors report that this medication should be taken only after an individual consultation with a specialist.

Tablets "Tizalud" are taken orally (orally), washed down with plain water, regardless of the meal.

The dosage of this medicine depends on the type and course of the disease. According to the instructions, for neurological pathologies that cause painful (spastic) contraction of muscle tissue, it is recommended to start treatment with a daily dose of 6 mg, which is divided into three doses. Depending on the nature of the spasm and pain, the next 3-7 days this amount of the drug can be increased by 2-4 mg.

As medical practice shows, the maximum therapeutic effect is observed when taking a daily dose of 12-24 mg. At the same time, 36 mg is the maximum allowable daily dosage.

To stop painful spasms of skeletal muscles, Tizalud tablets, reviews of which are ambiguous, are prescribed 2-4 mg three times a day. In especially severe cases, doctors recommend an additional medication at night in the same amount (that is, 2-4 mg).

The duration of the use of the drug "Tizalud" depends on the dynamics of muscle-tonic and pain manifestations. As a rule, acute muscle pains require careful treatment for 8-20 days. In chronic pain syndrome, depending on the severity and origin, the patient may need a longer therapy, which is determined on an individual basis (may last for one year).

Side reactions

Unfortunately, taking the medication in question can cause many negative reactions from the central nervous system, digestive tract, cardiovascular and respiratory system and others. Among the most frequently seen side effects the following can be distinguished:

• nausea, hepatitis, dizziness, dyspepsia;
• drowsiness, bradycardia, hallucinations;
• liver failure, sleep disturbances, dry mouth;
• insomnia, increased activity of liver transaminases, muscle weakness, lowering blood pressure;
• increased fatigue, hypercreatininemia.

It should also be noted that the abrupt withdrawal of the drug "Tizalud", especially after its combination with antihypertensive drugs and prolonged treatment or taking large doses, can quite easily lead to the development of tachycardia, increased blood pressure, and in some cases to acute cerebrovascular accident. .

Overdose of tablets "Tizalud"

With a sufficiently gross and regular violation of the dosing regimen, as well as when taking high doses of the drug in question, the patient experiences the following conditions: drowsiness, nausea, turning into vomiting, dizziness, development of hypotension, anxiety, miosis, coma, respiratory failure.

With such symptoms, the patient requires immediate gastric lavage, as well as bowel cleansing with an enema. In addition, the victim is shown taking sorbents, diuresis (forced) and further symptomatic therapy.

Interaction with other medicines

Tizalud according to the instructions can cause a “withdrawal” syndrome, therefore, at the end of treatment, the dose must be reduced gradually.

Release form and composition

The drug Tizalud is produced in the form of tablets containing the active substance (tizanidine) in the amount of 2 mg and 4 mg.

Tizalud's analogues for the active substance are the medicines Sirdalud, Tizanidin-Teva, Tizanil and Sirdalud MR.

If necessary, due to hypersensitivity or contraindications, the doctor may recommend the use of one of the Tizalud analogues with a similar mechanism of action: Baclosan, Tolperison-OBL, Mydocalm, Tolperison and Mydocalm-Richter.

Indications for use Tizalud

The drug Tizalud according to the instructions is prescribed for the treatment of painful muscle spasms:

• Associated with functional and organic disorders of the spine, including osteochondrosis, cervical and lumbar syndromes, syringomyelia, spondylosis and hemiplegia;
• Arising after surgical operations, including operations for the hip joint or intervertebral disc;
• Arising from spasticity of skeletal muscles against the background of various neurological diseases, including multiple sclerosis, chronic myelopathy, degenerative diseases of the spinal cord, residual effects transferred, traumatic brain injury, cerebral palsy.

Contraindications

According to the instructions Tizalud contraindicated to take:

• Against the background of hypersensitivity to the active (tizanidine) or auxiliary components that make up the tablets;
• During lactation;
• Simultaneously with potent inhibitors of the CYP1A2 isoenzyme;
• Against the background of severe liver failure;
• During pregnancy;
• In pediatrics.

With extreme caution, you should take Tizalud tablets:

• Simultaneously with oral contraceptives;
• With arterial hypotension;
• Against the background of hepatic or renal insufficiency;
• With the syndrome of congenital prolongation of the Q-T interval;
• Against the background of bradycardia;
• Elderly people over 65 years old.

Method of application and dosage

To reduce the severity of painful muscle spasm, 1-2 tablets of Tizalud (2 mg) are usually prescribed three times a day. When severe course diseases, you can additionally take a single dosage at night.

In the treatment of spasticity, which is caused by neurological diseases, Tizalud is prescribed at an initial dosage of 2 mg, which is taken 3 times a day. Perhaps a gradual increase (at intervals of 3-7 days) of a single dosage of 2-4 mg. The maximum daily dosage is 36 mg divided into 3-4 times.

When prescribing Tizalud in a daily dosage of more than 12 mg, it is necessary to evaluate liver function at least once a month for four months. If the activity of AST and ALT during this period exceeds the upper limit of the norm by more than 3 times, Tizalud is discontinued.

Side effects of Tizalud

According to reviews, the drug Tizalud most often causes drowsiness, lowering blood pressure, dryness of the oral mucosa, fatigue, bradycardia, hypercreatininemia.

In addition, according to reviews, Tizalud can lead to the development of:

• Insomnia, hallucinations and sleep disorders (nervous system);
• , nausea, hepatitis and liver failure (digestive system);
• Muscle weakness (musculoskeletal system).

Abrupt withdrawal of Tizalud after prolonged therapy, as well as after taking it in high doses or simultaneously with antihypertensive drugs, can cause an increase in blood pressure, in some cases, a violation of cerebral circulation, which occurs in an acute form.

Also, Tizalud, according to reviews, when taken in high doses, can lead to an overdose, manifested in the form of nausea, respiratory failure, a pronounced decrease in blood pressure, dizziness, drowsiness, miosis, anxiety, coma. For treatment, in addition to gastric lavage, repeated intake of activated charcoal is indicated. Also in this case, forced diuresis is performed.

drug interaction

According to the instructions, Tizalud is not recommended to be taken simultaneously with antihypertensive drugs due to the risk of a pronounced decrease in blood pressure and the development of bradycardia. It is also considered undesirable to use the drug together with other alpha2-agonists.

Sedative drugs and ethanol can increase side effects associated with depression of the central nervous system.

Simultaneous use with oral contraceptive medicines may lead to a decrease in the effectiveness of Tizalud.

Storage conditions

Tizalud is one of the centrally acting muscle relaxants dispensed from pharmacies as prescribed by a doctor. The shelf life of the tablets is 24 months, subject to the manufacturer's recommended storage conditions.

Tizalud is intended to reduce spasms of skeletal muscles, reduce their resistance to movement and eliminate clonic convulsions.

It is made on the basis of the active substance - tizanidine. It is used as an antispasmodic for painful muscle spasms. Tizanidin increases the strength of voluntary muscle contractions, relaxation skeletal muscles in spastic conditions of cerebral and spinal origin.

Indications for use

Tizalud tablets are prescribed for the following neurological diseases:

• stroke;
• chronic myelopathy;
• osteochondrosis;
• cerebral paralysis;
• circulatory disorders of the brain;
• multiple sclerosis;
• for the treatment of various lesions of the spine;
• with craniocerebral injuries;
• in postoperative periods with osteoarthritis of the hip and herniated discs.

Contraindications

Do not take Tizalud tablets if you have:

• hypersensitivity to tizanidine;
• severe liver and kidney pathologies;
• with caution should be taken when using oral contraceptives, with arterial hypotension.

Side effects

When taking Tezalude, drowsiness, fatigue, nausea, decreased blood pressure, insomnia, dry mouth, muscle weakness, liver failure, skin rash, itching are observed. With a sharp withdrawal of the drug, tachycardia, cerebrovascular accident may develop.

Analogues

Analogues according to the ATC code, form of release and composition of active substances include the following drugs:

• Tizanidin-Ratiopharm;
• Myoflex;
• Miaksil;
• Baclofen.

Muscle relaxant of central action. The mechanism of action is associated with stimulation of presynaptic α2 receptors, which leads to suppression of the release of excitatory amino acids (glutamic acid, aspartic acid), which stimulate receptors for N-methyl-D-aspartate. As a result, at the level of intermediate neurons of the spinal cord, polysynaptic transmission of excitation is suppressed. It also has a moderate central analgesic effect due to the inhibition of the function of the intercalary neurons of the posterior horns of the spinal cord. Reduces resistance to passive movements, reduces spasms and clonic convulsions, increases the strength of voluntary contractions. Does not affect neuromuscular transmission.
After application, tizanidine is rapidly and almost completely absorbed from the gastrointestinal tract. Simultaneous food intake does not affect the pharmacokinetics of tizanidine. In the dose range from 4 to 20 mg, the pharmacokinetics of the drug is linear. The drug is characterized by a low individual breadth of pharmacokinetic parameters. The maximum plasma concentration is reached 1-2 hours after ingestion. Due to the pronounced effect of the first passage through the liver, bioavailability is 34%, binding to plasma proteins is 30%. Tizanidine is rapidly and extensively metabolized in the liver to form inactive metabolites. Penetrates through the BBB, in a small amount - into breast milk. The elimination half-life from the systemic circulation is 2-4 hours. Excretion occurs mainly by the kidneys (60-70%) and intestines (20-25%), mainly in the form of metabolites, as well as unchanged (about 5%).
In patients with renal insufficiency (creatinine clearance ≤25 ml / min), the maximum plasma concentration exceeds this indicator in healthy volunteers by 2 times, the half-life is extended to 14 hours.
When taken orally, the effect of the drug appears after 30-45 minutes, the maximum effect occurs within 1-2 hours.

Indications for the use of the drug Tizalud

painful muscle spasm associated with static and functional diseases of the spine (cervical and lumbar syndromes), as well as after surgical interventions (for a herniated disc, osteoarthritis of the hip joint); spasticity of skeletal muscles in neurological diseases (multiple sclerosis, chronic myelopathy, degenerative diseases of the spinal cord, cerebrovascular accidents, cerebral palsy).

The use of the drug Tizalud

Adults take orally, regardless of food, with a small amount of liquid. The dosage regimen is set individually, taking into account the indications, efficacy and tolerability of therapy.
At painful muscle spasm appoint 2 or 4 mg 3 times a day. In severe cases, 2 or 4 mg of tizanidine is additionally prescribed at night.
At spasticity of skeletal muscles due to neurological diseases, the initial daily dose should not exceed 6 mg (2 mg 3 times a day). The daily dose can be increased gradually by 2-4 mg / day, at intervals of 3-4 to 7 days. Usually the optimal therapeutic effect is achieved with a daily dose of 12-24 mg, divided into 3 or 4 doses at regular intervals.
The highest dose of tizanidine for adults is 36 mg/day.
In patients with renal insufficiency (creatinine clearance ≤25 ml / min), the initial dose is 2 mg 1 time per day. Increasing the dose should be carried out gradually, taking into account the effectiveness and tolerability of therapy. If a more pronounced effect is needed, it is recommended to first increase the dose applied once a day, after which the frequency of use is increased.
The duration of the course of therapy is determined depending on the dynamics of muscle-tonic and pain manifestations. At acute pain muscle genesis, the duration of the drug is from 1 to 2-3 weeks. With chronic pain syndromes a longer course may be needed, which is determined individually and averages from 3-6 weeks to 1 year.

Contraindications to the use of the drug Tizalud

Severe liver dysfunction, concomitant use of fluvoxamine, increased individual sensitivity to the components of the drug, during pregnancy and lactation, children under the age of 18 years.

Side effects of the drug Tyzalud

From the CNS: drowsiness, weakness, dizziness, dry mouth; rarely - sleep disorders, hallucinations.
From the side of the musculoskeletal system: rarely - muscle weakness.
From the gastrointestinal tract: rarely - nausea, gastrointestinal disorders, transient increase in liver transaminase activity; very rarely - acute hepatitis.
From the side of the cardiovascular system: often - a decrease in blood pressure, bradycardia.
Others: fatigue, rarely - allergic reactions (skin itching, rash, urticaria).

Special instructions for the use of the drug Tizalud

Use with caution in elderly patients due to the likelihood of a significant decrease in renal clearance.
When side effects, possibly associated with impaired liver function (unexplained nausea, anorexia, fatigue), as well as in patients using tizanidine at a daily dose of 12 mg, it is necessary to monitor liver function tests once a month for the first 4 months of treatment. In the case when the levels of hepatic transaminases in the blood serum persistently exceed the upper limit of the norm by ≥3 times, the use of the drug should be discontinued.
Since the tablets contain lactose, it is not recommended to use the drug in patients with hereditary galactose intolerance, severe lactase deficiency and malabsorption of glucose (galactose).
Use during pregnancy and lactation. Taking the drug during pregnancy is contraindicated. If treatment with tizanidine is necessary, breast-feeding should be discontinued.
Influence on the ability to drive vehicles and mechanisms. If side effects from the central nervous system (drowsiness, etc.) occur, patients should refrain from activities that require a high concentration of attention and a quick reaction, such as driving Vehicle or work with machines and mechanisms.

Interactions of the drug Tyzalud

Concomitant use of tizanidine with the CYP1A2 inhibitor fluvoxamine is contraindicated.
Caution must be exercised when co-administering tizanidine with other CYP1A2 inhibitors, namely: antiarrhythmic agents (amiodarone, mexiletine, propafenone), cimetidine, fluoroquinolones (enoxacin, pefloxacin, ciprofloxacin, norfloxacin), rofecoxib, oral contraceptives and ticlopidine.
With the simultaneous use of tizanidine and antihypertensive drugs, including diuretics, arterial hypotension and bradycardia may develop.
When combined, sedatives and alcohol may enhance the sedative effect of tizanidine.

Overdose of the drug Tizalud, symptoms and treatment

If the recommended doses are exceeded, nausea, vomiting, arterial hypotension, dizziness, drowsiness, miosis, anxiety, respiratory failure, coma are possible. .
Treatment: withdrawal of the drug, gastric and intestinal lavage, repeated intake of activated charcoal, symptomatic therapy. Forced diuresis is shown. There is no specific antidote.

Storage conditions of the drug Tizalud

At a temperature not higher than 25 °C.

List of pharmacies where you can buy Tizalud:

• Saint Petersburg