Claritin tablets: instructions for use. Claritin: instructions for use for children and adults, analogues of Claritin from which pills help

According to statistics in modern world from all kinds of allergic reactions suffer from 35 to 50% of the population, and in different countries indicators vary. Scientists, chemists and pharmacologists are constantly working on the creation of new antihistamines designed to make life easier for allergic people. One of the best achievements of pharmacists is Claritin, a new generation anti-allergy drug.

A little about allergies

Allergy is a very insidious disease. There are frequent cases when it accompanies a person throughout life, being part of heredity. Unfortunately, no one is able to be 100% safe from allergies - it can manifest itself at any age.

What is an allergy? This is an uncharacteristic acute reaction of the body to any substances that the body deals with in everyday life. How such a reaction will manifest itself and how often depends on the individual case. The very mechanism of the appearance of allergies is not amenable to comprehensive study. Scientists can identify only some of the factors that influence the onset of such a condition in humans.

Against the background of a general decrease in immunity, the body may inadequately respond to both natural (dust, wool, pollen, food, etc.) and synthetic (household chemicals) substances that enter the internal environment through mucous membranes, skin, digestive tract.
One more direction scientific research, which were carried out in order to discover the causes of allergies - stress and psychological problems. The price that the body pays for lack of sleep, sleep disorders, psycho-emotional stress and unbalanced nutrition is a violation of work immune system. As a result, the immune system reacts unpredictably to any, even the usual substance.

Diagnosis and treatment of allergies always cause great difficulties and may remain unexplained for a long time. And in order to improve the quality of life of an allergic person, drugs such as Claritin and its analogues are being developed.

Claritin (tablets and syrup) was created specifically to eliminate the effects of allergic reactions: cough, swelling of mucous membranes, sneezing, skin redness and itching, rhinitis and conjunctivitis. These are the most common allergy symptoms.

Claritin - an ambulance for allergies

Claritin tablets and syrup are the result of many years of work by American scientists from Schering Plough. They presented their development to the world more than 20 years ago, and during this period of time the drug received exceptionally high reviews from both patients and doctors. He, of course, has analogues, the price of some of them is lower, but alternative drugs do not always fully compensate for the needs of the patient.

The action of the drug is based on the possibility of blocking histamine receptors. In contact with the allergen, the cells human body they try to reject the detected foreign body and produce for this a special biogenic substance - histamine. And Claritin and analogues with the same active substance act as antihistamines - blockers of H 1 receptors. Earlier versions of anti-allergic drugs also neutralized H 1 receptors, but along the way they also affected other nerve endings, causing drowsiness, lethargy, and sometimes complete disability. To relieve allergic symptoms, they had to be taken several times a day.

Active scientific research has contributed to the emergence of a new generation of antihistamines, which include Claritin. They have a number of advantages:

for sustainable relief of the condition of the tablet or syrup, it is enough to take it once a day;
modern drugs are not able to overcome the blood-brain protection, therefore, they do not have a sedative effect if the recommended dose is not exceeded;
when taking such antihistamines, other types of receptors do not suffer;
Claritin and its analogues begin to act in a matter of minutes, bringing a long-awaited relief to a person and reliably neutralizing H 1 receptors.

The effectiveness of Claritin is provided by the active ingredient loratadine, which is another unique development of specialists from the American company Schering Plough. Analogues of the drug are also based on loratadine, but with different additional components. Reviews of allergists and patients who used tablets or syrup indicate a positive effect of the drug to eliminate typical allergic symptoms: skin rashes and itching, swelling of the mucous membranes and extremities. It also has a membrane-stabilizing effect and prevents bronchospasm from developing.

The action of the drug begins a maximum of 25-35 minutes after ingestion, the duration of the antihistamine effect is at least 24 hours.

Forms of release of the drug

In pharmacies, you will be offered tablets and syrup.

Tablets with a dosage of 10 mg are white, oval with a dividing strip in the middle. In addition to the main active ingredient loratadine, the drug contains auxiliary hypoallergenic components. Tablets are packed in blisters and a cardboard outer box. Packing of 7, 10, 20, 30 pieces in a blister.

The syrup contains 1 mg of loratadine per 1 ml of volume. Thick, colorless, odorless syrup is intended for children aged 2 and more years. It is poured into bottles of 120 or 60 ml. The bottle made of impact-resistant dark glass is packed in a cardboard box along with a dosing syringe or spoon.

General indications for use

This drug is actively used both for the treatment and for the prevention of allergy manifestations. Claritin tablets and syrup are prescribed to eliminate rhinitis, conjunctivitis, rhinorrhea, sinusitis, swelling of tissues, to treat eczema, dermatitis, psoriasis, itchy dermatosis, to relieve Quincke's edema, bronchospasm.

Primary and further use of the drug, despite consistently positive reviews, requires mandatory medical consultation.

Claritin: instructions for use

Syrup and tablets can be taken at any time of the day - eating before or after does not play a role. For better absorption, any of the forms of the drug should be washed down with a small amount of clean water.

Quantity and doses:

10 mg tablets for adults and adolescents from 12 years of age should be taken 1 piece 1 time per day;
tablets can be replaced with syrup - its dose for adults and adolescents from 12 years old corresponds to 2 teaspoons (10 ml) 1 time per day;
for children from 2 to 12 years old, a single dose of the drug is calculated based on body weight: up to 30 kg -5 ml of syrup (1 teaspoon) or 5 mg tablets (half), more than 30 kg -10 ml of syrup (2 teaspoons) or 10 mg tablets (1 piece);
if the patient is diagnosed with severe liver dysfunction, then the drug is prescribed in the above dosage, but with a frequency of administration every other day;
for people of advanced age, as well as for patients diagnosed with chronic kidney failure dose is not adjusted.

Interaction

Taking the drug does not have an additional effect on the central nervous system and does not increase the effect of alcohol. Driving is acceptable when taking a single prescribed dose.

Together with erythromycins, ketoconazole, cimetidines, a surge in the concentration of loratadine is recorded, which, however, does not have a serious clinical significance.

Application during pregnancy

There are no data and reviews about taking the drug during pregnancy. Claritin is prescribed only in exceptional cases, when, in the opinion of the council, the benefits of its use for a pregnant woman will outweigh the possible risks to the fetus.

The main active substance of Claritin enters the breast milk, therefore, it is better to refuse it during lactation.

Side effects and overdose

Side effects of the drug are insignificant and were observed only in a small percentage of those participating in clinical research children and adults:

small manifestations of tachycardia;
nausea, vomiting, dry mucous membranes;
headache;
prostration;
in children, nervous irritability or lethargy;
liver dysfunction;
anaphylactic shock.

In case of an overdose, as the reviews testify, the symptoms are typical: headache, tachycardia, drowsiness. Overdose is treated symptomatically. Mandatory gastric lavage followed by the use of sorbents such as activated carbon or enterosgel.

Contraindications

The drug is not prescribed:

pregnant women;
children under 2 years of age;
people with special sensitivity to Claritin components;
people with certain rare hereditary diseases;
people with sucrase deficiency and fructose intolerance.

It is prescribed with extreme caution to patients with a history of severe signs of liver dysfunction.

Analogues

Substitutes for the drug often have a lower cost and are available to those categories of the population that cannot afford to purchase the original. They are also an alternative to Claritin if it is not available in the pharmacy network of the locality. Analogue drugs should not be confused with synonymous drugs that have the same composition as the original, but have different names due to licensing restrictions. The analogues are similar in action, but the composition is somewhat different, and the means may differ from the original in efficiency, therefore, only a doctor should select an equivalent replacement.

Claritin analogues in the domestic market: Loratadin Verte (the most affordable) - price up to 35 rubles, Zirtek - up to 200 rubles, Loratadin - from 40 rubles, Clarotadin - a little more than 100 rubles.

The original Claritin can be purchased at a price of up to 250 rubles for a blister of 10 pcs. or 270 rubles for 60 ml syrup.

In this article, you can read the instructions for using the drug Claritin. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Claritin in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Claritin in the presence of existing structural analogues. Use for the treatment of allergies and pollinosis in adults, children, as well as during pregnancy and lactation. The composition and interaction of the drug with alcohol.

Claritin - antihistamine, a blocker of peripheral histamine H1 receptors. It has a fast and long-term anti-allergic effect.

Improvement is noted within the first 30 minutes after taking the drug. The antihistamine effect reaches a maximum after 8-12 hours from the onset of action and lasts more than 24 hours.

Compound

Loratadine + excipients.

Pharmacokinetics

The drug is rapidly absorbed from the gastrointestinal tract. Excreted with urine and bile.

Indications

seasonal (hay fever) and year-round allergic rhinitis and allergic conjunctivitis (to eliminate the symptoms associated with these diseases - sneezing, itching of the nasal mucosa, rhinorrhea, burning sensation and itching in the eyes, lacrimation);
chronic idiopathic urticaria;
skin diseases of allergic origin.

Release forms

Tablets 10 mg.

Other dosage forms the drug, whether it be an ointment or drops, did not exist in the reference book at the time of the description of the drug.

Instructions for use and regimen

The drug is administered orally, regardless of the meal.

Adults (including the elderly) and adolescents over the age of 12 are recommended to take Claritin at a dose of 10 mg (1 tablet or 2 teaspoons (10 ml) of syrup) 1 time per day.

For patients with impaired liver function or renal insufficiency, the initial dose should be 10 mg (1 tablet or 2 teaspoons (10 ml) of syrup) every other day.

For children aged 2 to 12 years, the dose of Claritin is recommended depending on body weight: with a body weight of less than 30 kg - 5 mg (1/2 tablet or 1 teaspoon (5 ml) of syrup) 1 time per day, with body weight 30 kg or more - 10 mg (1 tablet or 2 teaspoons (10 ml) of syrup) 1 time per day.

Side effect

headache;
fatigue;
dry mouth;
drowsiness;
headache;
nervousness;
sedative action;
nausea;
gastritis;
heartbeat;
tachycardia;
skin rash;
anaphylaxis;
alopecia.

Contraindications

children under 2 years of age;
lactation period ( breastfeeding);
hypersensitivity to loratadine or any other component of the drug.

Use during pregnancy and lactation

The use of Claritin during pregnancy is possible only if the intended benefit to the mother outweighs the potential risk to the fetus.

The active components of the drug are excreted in breast milk, therefore, when prescribing the drug during lactation, the issue of stopping breastfeeding should be resolved.

drug interaction

Claritin does not enhance the effect of ethanol (alcohol) on the central nervous system.

When Claritin was co-administered with ketoconazole, erythromycin or cimetidine, an increase in plasma concentrations of loratadine and its metabolite was noted, but this increase was not clinically manifested, incl. according to the ECG.

Analogues of the drug Claritin

Structural analogues for the active substance:

Alerprive;
Vero-Loratadine;
Clallergin;
Clargotil;
Claridol;
Claricens;
Clarifer;
Clarotadine;
Lomilan;
Lomilan Solo;
LoraGeksal;
Loratadine;
Lotharen;
Tyrlor;
Erolyn.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Part tablets includes an active ingredient loratadine. Excipients: lactose monohydrate, magnesium stearate, corn starch.

Syrup contains an active ingredient loratadine . Excipients: propylene glycol , , citric acid monohydrate monohydrate, sodium benzoate, sucrose, peach flavor, purified water.

Release form

Claritin is available in the form of tablets and syrup. The drug is in tablets, packed in 15, 10 or 7 pieces in blisters, 1-3 blisters in a pack.

The syrup is offered in pharmacies in bottles of 60 or 120 ml with a plastic spoon dispenser, packed in a cardboard box.

pharmachologic effect

Each form of this drug has antipruritic , antihistamine and antiallergic effect.

Pharmacodynamics and pharmacokinetics

This antihistamine drug is a selective blocker of peripheral H1-histamine receptors, showing a rapid and prolonged antiallergic effect. The drug usually takes effect within 30 minutes.

The achievement of the antihistamine effect is noted after 8-12 hours and persists for at least 24 hours. At the same time, the active substance of the drug does not penetrate the blood-brain barrier, does not affect nervous system, does not show anticholinergic and sedative effects and does not affect the development of psychomotor reactions. Treatment with Claritin does not prolong the QT interval on the ECG.

Once inside the body, the drug undergoes rapid absorption in the gastrointestinal tract. The maximum concentration of the component in the composition is reached within 1.5-2.5 hours.

The result is a substance . Excretion of the drug from the body occurs in the composition of urine and bile in and unchanged within 6-92 hours. The rate of excretion of the drug from the body depends on the age, presence of diseases and other characteristics of the patient.

Indications for use Claritin

The main indications for the use of Claritin (from which tablets):

year-round or seasonal , ;
chronic idiopathic;
on the skin.

Contraindications

intolerance or high sensitivity to the components;
under 2 years of age;

Side effects

During treatment with this drug, you may experience side effects in the form of headache, fatigue, dry mouth, drowsiness, gastrointestinal disorders, allergic manifestations on the skin. In addition, it is possible to develop anaphylaxis, alopecia, tachycardia, disorders of the liver, heart.

Small patients may be disturbed by headache, nervousness, sedative effects.

Instructions for use Claritin (Method and dosage)

Each form of the drug is intended for oral administration at any time, if necessary.

Tablets Claritin instruction for use recommends prescribing adult patients and children over 12 years of age. Usually it is enough to take 10 mg of the drug daily. Patients with abnormalities in the work of the liver or kidneys, the drug is prescribed for admission every other day.

For children 2-12 years old, the drug is usually prescribed in syrup. At the same time, Claritin syrup instructions for use advise taking it in a certain dosage, which is calculated taking into account weight.

Overdose

In cases of overdose, the development of symptoms such as , and . This situation requires immediate medical attention.

Therapy for overdose symptoms includes: gastric lavage, then taking adsorbents and symptomatic remedies carrying out additional procedures.

Interaction

The combined use of this drug and , or may increase the concentration of loratadine in the body or its metabolite. However, this is of little clinical significance.

Terms of sale

Without recipe.

Storage conditions

Claritin syrup or tablets can be stored at temperatures up to 25 ° C, out of the reach of children.

Best before date

Tablets have a shelf life of 4 years, and syrup - 3 years.

Claritin's analogs

Coincidence in the ATX code of the 4th level:

More popular than cheap analogues Claritin: Loratadine, , and . Also have a similar effect: , Lotharen, Clallergin, Clarifarm, Clarifer, Klarfast, Alerprive, Klargottil and Erolyn . The price of analogues varies between 20-350 rubles.

Claritin or Erius - what's better?

The question is often found on the net, which of these drugs is better? Each of them is a new generation antiallergic antihistamine drug. Therefore, they are characterized by almost the same strength of therapeutic action and a minimum side effects. However, it is believed that Erius has a wider spectrum of action, as it is active in eliminating allergic cough.

However, you can find a lot of reviews when patients report that Erius does not help them and they began to take Claritin or vice versa. Thus, the question of choosing a drug depends on the individual characteristics of each person.

Claritin for children

Treatment of small patients can be carried out with the drug in the form of tablets or syrup. In this case, children can take the medicine once a day in a certain dosage.

The calculation of the dosage instructions for Claritin for children recommends that it be carried out depending on the weight. For example, with a weight of up to 30 kg, it is permissible to take syrup for children daily, 1 teaspoon or ½ tablet.

Patients weighing more than 30 kg are prescribed 2 teaspoons of syrup or 1 tablet daily. As a rule, parents leave positive reviews about syrup for children online.

Alcohol compatibility

At various medical forums, the question is often asked: is alcohol and Claritin treatment compatible? According to experts, the use of alcohol does not have a special effect on the effectiveness of this drug, but the possibility of unwanted effects is not excluded. For this reason, it is not recommended to take alcohol at the same time as the medicine.

Claritin during pregnancy and lactation

As stated in the instructions, the use of the drug for allowed when the expected benefit to the mother outweighs the risk to the fetus.

It has also been found that the active substance is excreted in the composition of breast milk, therefore, when breastfeeding, taking these allergy pills is contraindicated.

Reviews about Claritin

The network quite often reviews Claritin in tablets and syrup, but the opinion of users about its action is very ambiguous. Many people report that treatment with this drug has worked for them. Although some patients had to look for a more suitable remedy, as they allergic symptoms decreased only slightly.

As clarified by allergists - specialists who study and treat this disorder - each person can be disturbed by various kinds of allergies. Therefore, one drug is simply not capable of eliminating the manifestation of various symptoms. For such patients, the only recourse is to take several different drugs or their forms, such as tablets and nasal spray.

Despite the high popularity, both tablets and syrup for children do not have such a wide spectrum of action that allows you to simultaneously eliminate all manifestations of allergies. Moreover, there are also reports of the development of side effects, for example, headache, drowsiness, skin manifestations. Of course, if any adverse reactions occur, you should consult a doctor to exclude the presence of another disease with similar symptoms.

The fact that in pharmacies this drug is dispensed without a prescription does not mean at all that it can be taken on its own without the appointment of an allergist. Therefore, if there are symptoms indicating the development of an allergy, you should immediately consult a doctor. If this is not done in a timely manner, gradually the symptoms will only worsen.

Claritin price, where to buy

Price Claritin tablets is 130-570 rubles.

Price syrup Claritin varies between 220-380 rubles.

The price of Claritin in Ukraine (in cities such as Kiev and Kharkov) is from 156 UAH.

You can buy the drug in St. Petersburg at a price of 140 rubles. At the same time, the cost in the Russian regions is somewhat lower. You can find out how much an allergy medicine of any form costs at the reference pharmacy of the city of interest or on pharmacy websites.

Internet pharmacies in Russia Russia
Internet pharmacies of Ukraine Ukraine
Internet pharmacies of Kazakhstan Kazakhstan

ZdravCity

Claritin syrup 5mg/5ml 60ml Schering-Plough Labo N.V.

Claritin tab. 10mg n10 Schering-Plough Labo N.V.

Allergy is one of the three most common diseases in the world. Manifested by a rash, nasal congestion or rarely swelling, it does not cause concern for everyone, but in vain. In extreme cases, in the absence of a qualified medical care an allergic reaction can cause lethal outcome. One of the most effective drugs that are used to combat its manifestations is Claritin. Effective and safe, it is suitable for the treatment and prevention of adults and children.

General information

Claritin is manufactured by SCHERING-PLOUGH LABO N.V. The drug has a pronounced:

antiallergic;
antihistamine;
antipruritic actions.

The mechanism of its effect on the body is simple: it blocks histamine receptors, and already half an hour after ingestion, maintaining a therapeutic effect for up to 24 hours.

Note! Allergic manifestations are the result of the action of histamine on the body. This is a special substance that is released from the cells at the time of exposure to the allergen. Subsequently, histamine binds to histamine receptors, after which a series of reactions are triggered that directly provoke allergic manifestations. In other words, the blood flow increases, the skin and mucous membranes become inflamed, the person begins to sneeze, cough, and sometimes suffocate.

Claritin acts exclusively on histamine receptors, preventing the launch of reactions that lead to the development of allergic manifestations. Due to the fact that after ingestion, some reactions are already running, the patient may feel itchy or constantly sneeze for some time. Meanwhile, thanks to him, these signs quickly pass and relief comes.

The main advantages of Claritin are its versatility, since it is prescribed even for diseases accompanied by allergic reactions, as well as the absence of a sedative effect. Unlike drugs of the past generation, for example, Suprastin, it does not affect the histamine receptors of the central nervous system, and therefore does not cause inhibition of reactions.

Claritin also eliminates hyperemia of the skin, enhances the strength of the walls of blood vessels.

Release forms

You can buy Claritin in tablets or in syrup. In both forms, the active ingredient is loratadine. In one tablet - 10 mg of loratadine, and in 1 ml of syrup - 1 mg.

You can recognize the tablets by their unusual oval shape and a specific sign in the form of a flask or bowl on one of the sides. The manufacturer recommends focusing on this symbol to eliminate the risk of accepting a fake. For ease of separation, the tablets have a dash in the middle.

The syrup is a clear, sometimes yellowish liquid and is most commonly prescribed to treat children.

Important! The composition of tablets and syrup, in addition to the active substance, contains only components that are not able to influence the links of allergic reactions..

Indications

Claritin is used for the treatment and prevention of:

seasonal allergies that manifest themselves - a reaction to plant pollen;
, which persists throughout the year;
chronic form;
defeats skin having an allergic nature -,;
edema of various etymologies, including;
allergies to insect bites;
pseudo-allergy, provoked by the ingestion of histamine liberators - strawberries, chocolate, cocoa, tomatoes.

An allergic reaction is characterized by several signs that the drug effectively eliminates. This is about:

sneezing;
nasal congestion;
swelling of the mucous membranes and skin;
itching;
burning in the eyes;
rashes;
bronchospasm.

Method of administration and dose

There are no recommendations regarding the time of use of the drug. Tablets or syrup are drunk at the time of the appearance of signs of allergy, regardless of the meal. It is advisable to drink them with clean water.

Important! The dosage should be prescribed by a qualified specialist, taking into account the age and the presence of chronic diseases in a person.

Usually, babies under 3 years old are prescribed syrup, and older children - tablets. Moreover, it is not recommended to give Claritin before the child reaches 2 years of age. Take the drug once a day at the same time. Children's dosage is determined by body weight and is calculated using one of two formulas:

If the baby's body weight has not reached 30 kg, 5 mg of Claritin is prescribed - this is 1 measured or teaspoon or half a tablet.
If the body weight is more than 30 kg, 10 mg of Claritin is prescribed, respectively, 2 tablespoons or a whole tablet.

Note!Sometimes a pediatrician may recommend taking Claritin 10 mg at a time for a child who has not gained 30 kg, 1 time in 2 days. In extreme cases, infants are prescribed 1.5 ml of syrup at the age of up to 12 months and 3 ml of syrup at the age of up to 2 years to eliminate signs of allergy.

Children over 12 years of age and adults are prescribed the drug in the form of tablets, which are taken one per day at the same time. The only exceptions are people suffering from liver disease or kidney failure. They are recommended to take 1 tablet 1 time in 2 days or half a tablet every day.

The course of treatment is determined by the severity of symptoms and usually ranges from 7 to 14 days. When taking Claritin as a prophylactic, it can be extended for a month or more, but only after consultation with a specialist.

Important! At least 2 days before the allergy test, it is recommended to stop taking the drug in order to avoid false results.

Reception during pregnancy

Accurate data on the effect of the active substance of the drug on the fetus is not yet available. Experiments were conducted only with the participation of animals and showed no negative effects. On their basis, a doctor can prescribe Claritin to a pregnant woman, but only if the benefits of taking it outweigh the possible harm.

It is also worth noting that the drug also enters breast milk, and in it its concentration remains quite high, as in the blood. In this regard, it is not prescribed during lactation.

Side effects

Children and adults after taking Claritin may experience:

anxiety;
lethargy;
increased fatigue;
dry mouth;
cardiopalmus;
rash;
liver dysfunction.

Most often, these signs are the result of an overdose - taking more than 40 mg of loratadine at a time. At the same time, in children, violations of muscle tone, twitching or distortion of the lips, slow movements of the fingers, and trembling in the body may additionally appear.

Medical care for overdose comes down to gastric lavage and administration.

Claritin's analogs

You can replace Claritin with other drugs based on loratadine. Among them:

Loratadin-Teva;
Loratadine;
Erolyn;
Lomilan;
Clallergin;
Alepriv.

Analogues of the drug based on other active substances:

Histafen;
Diacin;
Diazolin;
Ketotifen;
Fexofast;
Rapido.

Terms and conditions of storage

Claritin is recommended to be stored in a dark place away from children, observing the temperature regime suitable for it: 2 - 30 C degrees. Tablets retain their properties for 4 years from the date of manufacture, syrup - for 3 years. You can't take them after.

special instructions

Despite the fact that the drug is well tolerated, when using it for the first time, it is better to give up excessive activity and not drive a vehicle. The selectivity of action, safety, efficiency and relatively low price have made it one of the most popular drugs in more than 100 countries around the world. Meanwhile, doctors do not advise to abuse it. For the treatment of short-term allergic manifestations, a single dose is sufficient. At the same time, if it is necessary to transfer the disease to a state of remission, it may take from 3 months to a year, during which the course of treatment is not interrupted.

SCHERING-PLOUGH LABO OTHER Schering-Plow Labo N.V.

Country of origin

Belgium

Product group

Antiallergic drugs

Antiallergic agent - Hj-histamine receptor blocker.

Release forms

10 - blisters (1) - packs of cardboard. 10 - blisters (3) - packs of cardboard. 120 ml - dark glass bottles (1) complete with a measuring spoon - packs of cardboard. 60 ml - dark glass bottles (1) complete with a measuring spoon - packs of cardboard. 7 - blisters (1) - packs of cardboard.

Description of the dosage form

a clear, colorless or yellowish syrup that does not contain visible particles. oval-shaped tablets of white or almost white color, not containing foreign inclusions, on one side there is a risk, the trademark "Cup and flask" and the number "10", the other side is smooth.

pharmachologic effect

Pharmacodynamics: loratadine - the active substance of the drug Claritin® - is a tricyclic compound with a pronounced antihistamine effect and is selective blocker peripheral Hi-histamine receptors. Possesses fast and long antiallergic action. The onset of action is within 30 minutes after taking Claritin® orally. The antihistamine effect reaches a maximum after 8-12 hours from the onset of action and lasts more than 24 hours. Loratadine does not cross the blood-brain barrier and does not affect the central nervous system. It does not have a clinically significant anticholinergic or sedative effect, i.e. does not cause drowsiness and does not affect the speed of psychomotor reactions when used in recommended doses. Taking the drug Claritin does not lead to prolongation of the QT interval on the ECG. At long-term treatment there were no clinically significant changes in vital signs, physical examination data, results laboratory research or electrocardiography. Loratadine does not have significant selectivity for Hg-histamine receptors. Does not inhibit the reuptake of norepinephrine and has virtually no effect on cardiovascular system or the pacemaker function.

Pharmacokinetics

Loratadine is rapidly and well absorbed into gastrointestinal tract. The time to reach the maximum concentration (Tmax) of loratadine in blood plasma is 1-1.5 hours, and its active metabolite desloratadine is 1.5-3.7 hours. Eating increases the time to reach maximum concentration (Tmax) of loratadine and desloratadine by approximately 1 hour, but does not affect the effectiveness of the drug. The maximum concentration (Cmax) of loratadine and desloratadine does not depend on food intake. In patients with chronic diseases kidneys, the maximum concentration (Cmax) and the area under the concentration-time curve (AUC) of loratadine and its active metabolite increase compared with patients with normal function kidneys. The half-life of loratadine and its active metabolite does not differ from those in healthy patients. In patients with alcoholic liver disease, Cmax and AUC of loratadine and its active metabolite are two times higher than in patients with normal liver function. Loratadine has a high degree (97-99%), and its active metabolite has a moderate degree (73-76%) of binding to plasma proteins. Loratadine is metabolized to desloratadine via the cytochrome P450 ZA4 system and, to a lesser extent, the cytochrome P450 2D6 system. It is excreted through the kidneys (approximately 40% of the dose taken orally) and through the intestines (approximately 42% of the dose taken orally) for more than 10 days, mainly in the form of conjugated metabolites. Approximately 27% of the ingested dose is excreted through the kidneys within 24 hours after taking the drug. Less than 1% of the active substance is excreted through the kidneys unchanged within 24 hours after taking the drug. The bioavailability of loratadine and its active metabolite is dose-dependent. The pharmacokinetic profiles of loratadine and its active metabolite in adult and elderly healthy volunteers were comparable. The half-life of loratadine is 3 to 20 hours (mean 8.4 hours) and that of desloratadine is 8.8 to 92 hours (mean 28 hours); in elderly patients, respectively, from 6.7 to 37 hours (average 18.2 hours) and from 11 to 39 hours (average 17.5 hours). The elimination half-life increases with alcoholic liver damage (depending on the severity of the disease) and does not change in the presence of chronic renal failure. Carrying out hemodialysis in patients with chronic renal failure does not affect the pharmacokinetics of loratadine and its active metabolite.

Special conditions

Children aged 2 to 3 years are recommended to take the drug Claritin® in the form of syrup. Claritin should be discontinued 48 hours before skin testing because antihistamines may interfere with diagnostic testing. Influence on the ability to drive / remove vehicles and control mechanisms No negative effect of the drug Claritin® on the ability to drive a car or carry out other activities that require increased concentration of attention has been identified. However, in a very rare cases some patients experience drowsiness while taking Claritin®, which may affect their ability to drive vehicles and work with machinery.

Compound

Loratadine 1 mg Excipients: citric acid, artificial flavor (peach), glycerol, propylene glycol, sodium benzoate, granulated sucrose, purified water. Loratadine 10 mg Excipients: corn starch, lactose, magnesium stearate.

Claritin indications for use

- seasonal (hay fever) and year-round allergic rhinitis and allergic conjunctivitis (to eliminate the symptoms associated with these diseases - sneezing, itching of the nasal mucosa, rhinorrhea, burning sensation and itching in the eyes, lacrimation); - chronic idiopathic urticaria; - skin diseases of allergic origin.

Claritin contraindications

- age up to 2 years; - lactation period (breastfeeding); - hypersensitivity to loratadine or any other component of the drug. With caution, the drug should be prescribed during pregnancy, liver failure.

Claritin dosage

1 mg/ml 10 mg

Claritin side effects

In clinical studies involving children aged 2 to 12 years who took the drug Claritin® more often than in the placebo group, headache (2.7%), nervousness (2.3%), fatigue (1%) were observed. In clinical studies involving adults, adverse events, which were observed more frequently than with placebo ("dummy"), occurred in 2% of patients taking the drug Claritin®. In adults, when using the drug Claritin® more often than in the placebo group, headache (0.6%), drowsiness (1.2%), increased appetite (0.5%) and insomnia (0.1%) were noted. In addition, there were very rare reports in the post-marketing period (

drug interaction

Eating does not affect the effectiveness of Claritin®. medicinal product Claritin® does not enhance the effects of alcohol on the central nervous system. When loratadine was co-administered with ketoconazole, erythromycin, or cimetidine, an increase in plasma loratadine concentration was noted, but this increase was not clinically significant, including according to electrocardiography.

Overdose

Symptoms: drowsiness, tachycardia, headache. In case of overdose, you should immediately consult a doctor. Treatment: symptomatic and supportive therapy. It is possible to wash the stomach, take adsorbents (crushed activated carbon with water). Loratadine is not excreted by hemodialysis. After rendering emergency care it is necessary to continue monitoring the patient's condition.

Storage conditions

keep away from children

Information provided by the State Register of Medicines.

Synonyms

Vero-Loratadin, Clarisens, Clarifer, Clarotadin, Lomilan, Loratadin 10-SL, Loratin, Loridin.