Amiksin instructions for use adult in tablets. Amiksin: instructions for use and what it is for, price, reviews, analogues

Content

Among the many drugs that are used for immunomodulatory purposes, the substance tilorone, which is contained in the drug Amixin, is preferred among analogues. In addition to active antiviral action, it is known that the substance is able to act as an antitumor and anti-inflammatory agent.

Amiksin - instruction

A medicine based on tilaxin (tilorone) helps to cope with many viral diseases by strengthening the immune system. The drug helps the body fight dangerous viruses by stimulating the production of interferon, reduces the level of immunosuppression, and restores the correct ratio of immune cells. In terms of its harmlessness and effect on the body, the drug surpasses its counterparts. Before taking, be sure to use the instructions for Amiksin so that the application is as effective and safe as possible.

Amiksin - composition

Amiksin's instruction provides comprehensive information not only about the composition, pharmacological action medicines, but also about what is the component of the tablets, which courses of administration are intended for treatment, and which ones are for the prevention of diseases in adults and children. The release form of the drug is convenient for taking - coated tablets. The main active ingredient of the tablets is tilorone, known as a synthetic interferon inducer. In addition to the active substance, Amiksin contains auxiliary, which include:

  • potato starch;
  • povidone;
  • cellulose;
  • calcium stearate;
  • primellose.

The shell of the tablets contains polyethylene glycol 4000, titanium dioxide, hypromellose, quinoline yellow dye, polysorbate 80, yellow-orange sikovit. Such names of the components of the composition may cause concern, but the drug is not toxic, and the described additives are allowed to be used in pharmacology and they are part of many medicines.

Amiksin - indications for use

Detailed, comprehensive information about the cases in which they drink Amiksin - the instructions for use are given after studying it and it becomes obvious that this drug is the best among its analogues. Indications for the use of Amiksin are as follows:

  • with different forms of influenza;
  • with viral hepatitis;
  • for the treatment of herpes infection;
  • with pulmonary tuberculosis;
  • with cytomegalovirus infection;
  • with acute respiratory viral infections;
  • to combat chlamydia urogenital, respiratory; encephalomyelitis of a viral, allergic nature.

How to take Amiksin

Before you start taking Amiksin, you need to be examined by a doctor who will prescribe you the correct regimen for taking the drug. For different diseases, the course dose and regimen are different, so it is important to know how to drink Amiksin in a particular case. There are classical schemes for the treatment of hepatitis, cytomegalovirus infection and immunodeficiencies:

  • for the prevention of hepatitis A - 125 mg once a week (dosage for a 6-week course - 750 mg);
  • to cure viral hepatitis A: the first day - two tablets of 125 mg, then - 125 mg every two days, 1.25 g is calculated for the course of administration; acute hepatitis B - the same scheme, only the course dose is 2 g; acute hepatitis C, cytomegalovirus infection - 2.5 g;
  • hepatitis B, C of the chronic form are treated as follows: the first two days - 250 mg of the drug, then - every two days, 125 mg each, the initial course dose is 2.5 g, the total dose is 5 g (after 2.5 g, 125 mg 1 once a week);
  • for immunocorrection in immunodeficiencies and HIV - 125-250 mg every week for 2 months, if necessary, the doctor may prescribe repeated courses with a break of 4 weeks;
  • with chlamydia (urogenital, respiratory) - the first 2 days, 125 mg, then the same dose every 48 hours, the course is 1.25 g; to cure neuro viral infections- a similar scheme with a course of 1.5 to 1.75 g.

Amiksin for colds

More often, antiviral drugs are prescribed for the treatment, prevention of acute respiratory viral infections, with influenza, when the body needs additional resources to fight mutated forms of viruses. Amixin for colds is prescribed according to the classical regimen - the first 2 days, 125 mg each, then every two days at the same dose, 750 mg is needed for the course. For prevention, they drink 125 mg once a week for a course of 6 weeks. Instructions for use describe the general course, but the doctor may adjust the dose based on the course of the disease and other possible factors.

Amixin for herpes

The drug is effective in various forms of herpes infection. Before starting the use of the drug, it is important to identify the form of the virus and the severity of the course of the disease. The active substance of the drug equally affects the virus different types, and appoint Amiksin from herpes to drink according to a certain scheme: the first day - two pills with a dosage of 0.125 g, then - at the same dosage every 48 hours. For the course, a dose of 2.5 g is drunk.

Amiksin with bronchitis

Based on the fact that most bronchitis are provoked by ARVI, then after diagnosing this disease prescribed antiviral drugs. Amiksin for bronchitis should be used according to the scheme of application for acute respiratory viral infections in the first 3 days after the symptoms are detected. If during these days the antiviral was not prescribed, then in the future its course will be ineffective. Self-medication should not be done, because sometimes bronchitis can be caused by a bacterial infection, in which case an antiviral agent is useless.

Amiksin with angina

Antivirals are effective in fighting viral diseases, but they will be useless in bacterial diseases. Amiksin with angina is mistakenly taken by people who do not know its mechanism of action. It has no information about the possibility of treating such diseases with this medicine, instructions for use, and angina cannot be cured without antibacterial agents. An antibiotic and an antiviral agent act in different areas and cannot be interchanged in any way, but they can have positive compatibility in complex therapy.

Amiksin for children

All drugs with antiviral activity are used with caution in children. The same medicines are intended for adults, since the children's immune system is weaker, more specific, therefore Amiksin for children can be prescribed only after the age of seven years. Children are treated for colds according to the scheme: for ARVI, the child is prescribed treatment with doses of 60 mg per day after meals on the first, 2nd and 4th days of treatment, the flu is treated similarly, with complications - an additional 60 mg on the 6th day according to the instructions .

Amiksin - side effects

Among the side effects of Amiksin, noted in the instructions for use, violations are more often observed digestive system, very rarely symptoms of dyspepsia are possible. As with any medicinal product, the formation of an allergic response is not excluded, especially if alcohol was consumed during the course of administration. There may be a feeling of chills at the beginning of taking the tablets.

Amiksin - contraindications

People with hypersensitivity to the main substance of the drug or to excipients are contraindicated to take it, and everyone can find out a detailed list of components - the instructions for use contain comprehensive information about the composition of the tablets. During pregnancy or while breastfeeding, this drug is contraindicated for women, and for children who have not reached the age of 7 years. Amiksin's contraindications are indicated in the instructions for use, so carefully study it before starting treatment.

Amiksin - analogues

It is known that analogues of this drug are drugs with a similar mechanism of action - interferon inducers, which may have other active substances. Tablets have a similar mechanism of action on the immune system, but it is dangerous for health to arbitrarily prescribe them instead of another similar drug, although the price of funds can vary significantly. The most popular analogues of Amiksin:

  • Alpizarin;
  • Viracept;
  • Hyporamine;
  • Groprinosin;
  • Ingavirin;
  • Kagocel;
  • Lavomax;
  • Nikavir;
  • Panavir;
  • Thylaxin;
  • Tiloron;
  • Celzentry.

Price for Amiksin

Nowadays, it is easy to buy any medicine in the online store. Often such a purchase is more profitable than in a regular pharmacy. The price of Amixin from different manufacturers may vary, but its cost does not exceed the limit of 1000 rubles for 10 pieces with a dosage of 0.125 g. You can find out how much Amixin costs from online pharmacy catalogs or from reviews and choose the price that suits your wallet . The average price for this medicine is 600 rubles per pack, and the price of a cheaper analogue (Lavomax) is 300-400 rubles.

general characteristics

Chemical Name: 2,7-bis--fluoren-9-one dihydrochloride

Description

Orange film-coated tablets, round, biconvex. On a break of orange color, insignificant blotches of orange and white color are allowed.

Composition

Each tablet contains:

Active substance: tilorone (tilaxin) - 60 mg or 125 mg.

Excipients:

Core: potato starch, microcrystalline cellulose, povidone-KZ0 (collidon 30), calcium stearate, croscarmellose sodium (primellose)

Shell: hypromellose (hydroxypropyl methylcellulose), titanium dioxide, macrogol-4000 (polyethylene glycol-4000), polysorbate-80 (tween-80), quinoline yellow dye (E 104), sunset yellow dye (E110).

The codeATX: . Other antivirus tools.

Pharmacological properties

Pharmacodynamics. Low molecular weight synthetic interferon inducer that stimulates the formation of all types of interferons (alpha, beta, gamma and lambda) in the body. The main producers of interferon in response to the introduction of tilorone are intestinal epithelial cells, hepatocytes, T-lymphocytes, neutrophils and granulocytes. After ingestion, the maximum production of interferon is determined in the sequence intestine - liver - blood after 4-24 hours.

In human leukocytes, it induces the synthesis of interferon. Stimulates bone marrow stem cells, depending on the dose enhances antibody formation, reduces the degree of immunosuppression, restores the ratio of T-suppressors and T-helpers. Effective against various viral infections, including influenza viruses, other acute respiratory viral infections, hepatitis viruses and herpes viruses. The mechanism of antiviral action is associated with the inhibition of translation of virus-specific proteins in infected cells, resulting in suppressed reproduction of viruses.

Pharmacokinetics. After oral administration, it is rapidly absorbed from the gastrointestinal tract. Bioavailability - 60%. About 80% of the drug binds to plasma proteins. The drug is excreted practically unchanged through the intestines (70%) and through the kidneys (9%). The half-life (T 1/2) is 48 hours. The drug does not undergo biotransformation and does not accumulate in the body.

Indications for use

In children over 7 years of age:

Treatment (as part of complex therapy) of influenza and other acute respiratory viral infections.

In adults (over 18 years of age):

Treatment (as part of complex therapy) and prevention of influenza and other acute respiratory viral infections;

As part of complex therapy and only as prescribed by the attending physician:

Treatment of viral hepatitis A, B and C; treatment of herpetic and cytomegalovirus infection; as part of the complex therapy of infectious-allergic and viral encephalomyelitis ( multiple sclerosis, leukoencephalitis, uveoencephalitis, etc.); as part of the complex therapy of urogenital and respiratory chlamydia; in the complex therapy of pulmonary tuberculosis, bacteriologically confirmed.

Method of application and dosage

Amiksin is taken orally after meals.

For children over 7 years old:

In uncomplicated forms of influenza and other acute respiratory viral infections - 60 mg once a day on the 1st, 2nd and 4th day from the start of treatment. Heading dose - 180 mg (3 tablets). In case of complications of influenza or other acute respiratory viral infections - 60 mg 1 time per day on the 1st, 2nd, 4th and 6th day from the start of treatment. Heading dose - 240 mg (4 tablets).

For adults (over 18):

For the treatment of influenza and other acute respiratory viral infections - 125 mg per day for the first 2 days of treatment, then 125 mg after 48 hours. Per course - 750 mg (6 tablets).

For the prevention of influenza and other acute respiratory viral infections - 125 mg once a week for 6 weeks. Per course - 750 mg (6 tablets).

For the treatment of herpetic, cytomegalovirus infection - the first two days, 125 mg, then after 48 hours, 125 mg. Heading dose - 1.25-2.5 g (10-20 tablets).

For the treatment of viral hepatitis A - on the first day, 125 mg 2 times, then 125 mg every 48 hours. Per course - 1.25 g (10 tablets).

For the treatment of acute hepatitis B - the first two days, 125 mg, then 125 mg after 48 hours, for the course of treatment - 2 g (16 tablets). With a protracted course of hepatitis B - 125 mg 2 times a day on the first day, then 125 mg after 48 hours. For the course of treatment - 2.5 g (20 tablets).

In chronic hepatitis B - the initial phase of treatment (2.5 g - 20 tablets) - the first two days, 125 mg 2 times a day, then 125 mg after 48 hours. Continuation phase (from 1.25 g - 10 tablets to 2.5 g - 20 tablets) - 125 mg per week. The course dose of Amiksin® is from 3.75 g to 5 g, the duration of therapy is 3.5-6 months, depending on the results of biochemical, immunological, morphological studies, reflecting the degree of activity of the process.

In acute hepatitis C - 125 mg per day for the first 2 days of treatment, then 125 mg after 48 hours. The course of treatment is 2.5 g (20 tablets).

In chronic hepatitis C - the initial phase of treatment (2.5 g - 20 tablets) - the first two days, 125 mg 2 times a day, then 125 mg after 48 hours. Continuation phase (2.5 g - 20 tablets) - 125 mg per week. The course dose of Amiksin® is 5 g, the duration of therapy is 6 months, depending on the results of biochemical, immunological, morphological markers of the activity of the process.

In the complex therapy of neuroviral infections - 125-250 mg per day for the first 2 days of treatment, then 125 mg after 48 hours. The dose is set individually, the course of treatment is 3-4 weeks.

With urogenital and respiratory chlamydia - the first two days, 125 mg, then after 48 hours, 125 mg. Heading dose - 1.25 g (10 tablets).

In the complex therapy of pulmonary tuberculosis - 250 mg for the first two days of treatment, then 125 mg after 48 hours. Heading dose - 2.5 g (20 tablets).

Patients with impaired liver function, kidney function, the elderly, dose adjustment is not required.

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Side effect

Allergic reactions, dyspeptic symptoms, short-term chills are possible.

Contraindications

Hypersensitivity to the drug. The period of pregnancy and lactation. Children's age up to 7 years.

Use during pregnancy and during breastfeeding

The use of the drug during pregnancy is contraindicated. If necessary, the use of the drug during lactation, breastfeeding should be discontinued.

Storage conditions and shelf life

In a place protected from light, at a temperature not exceeding 30 ° C.

Keep out of the reach of children.

3 years. Do not use after the expiry date stated on the packaging.

Terms of dispensing from pharmacies

Without a prescription - 125 mg film-coated tablets.

Prescription - 60 mg film-coated tablets.

Package

10 tablets - 60 mg, 6 or 10 tablets - 125 mg in a blister pack.

1 blister pack with instructions for use in a cardboard pack.

Name and address of the manufacturer / company accepting customer complaints

Amiksin is a drug that stimulates the production of interferon. Interferon is a protein human body, which is released after the virus enters the body, and serves as the first line of defense against it. The use of exogenous interferon in the fight against viruses encounters a lot of obstacles, because non-native interferon leads to mass side effects. Therefore, drugs such as Amiksin, which only increase the body's production of its own interferon, are at the forefront in the fight against viral infections.

Amiksin has found its application both in preventive medicine and in the treatment of liver diseases; it is used in acute and chronic forms of viral hepatitis; cytomegalovirus hepatitis, herpetic lesions, chlamydia, neuroinfections.

Amiksin, the instructions for use write about this, requires a long course of treatment with strict adherence to the prescribed dose. It is used in hepatology and gastroenterology, pediatric infectious disease specialists, neurologists and therapists.

During influenza epidemics, it can be taken as a preventive measure by adults without a doctor's prescription.

One tablet of Amiksin contains 60 mg, a children's dose, or 150 mg, an adult dose, tilorone and a small part of additional substances that are not involved in creating a therapeutic effect.

Amiksin tablets are coated and sold in packs of 20, 10 or 6 tablets per jar. This is done so that you can buy a specific exact amount of the drug that was prescribed.

Pharmacodynamics

Amiksin is an interferon inducer. This means that it provokes the production of its own interferon by the cells of the body. Amiksin is effective for the treatment of viral diseases with tropism for the gastrointestinal tract, bone and brain, blood cells. Thus, its mechanism is to increase the level of endogenous interferon. Sensitive to the action of the drug are: intestinal mucosa, liver cells, neutrophils, T lymphocytes. After application, the drug enters the intestine, passes through the liver. enterocytes and hepatocytes begin to produce interferon.

After the liver, the drug will spread through the superior vena cava throughout the body. Its antiviral and immunostimulating effects, as well as high efficiency, put Amiksin in first place among analogues. Instructions for use describe that Amiksin acts in comparison with its analogues on more tissues, increases cellular immunity and leads to the formation of blood cells in the bone marrow, especially lymphocytes.

The antiviral mechanism is provided by blocking the translation of virus-specific proteins in the cells of the body, which leads to the inability of virus division.

Pharmacokinetics

Amiksin is well absorbed by the intestinal epithelium, its bioavailability is 60%, which means that a sufficient amount of the drug enters the blood after absorption in the gastrointestinal tract. After that, it quickly binds to blood proteins by 80% and reaches its therapeutic effect 24 hours after ingestion. The drug does not accumulate and does not undergo biotransformation, but is excreted in feces and urine almost unchanged. This means that it does not linger in the body and cannot cause an overdose.

Amiksin overcomes the blood-brain barrier and achieves a therapeutic effect in neuroinfections of viral etiology. The placental barrier also passes, although its specific effect on the fetus and the course of pregnancy has not been proven, it is not recommended to take Amiksin during pregnancy, the instructions for use indicate this.

Indications

The important point is that Amiksin can be used as monotherapy mainly only for acute and chronic hepatitis and influenza, SARS, other pathologies involve the use of interferon production stimulants along with the main treatment.

Children's diseases for which Amiksin can be used:

  • treatment and prevention of influenza and SARS;
  • among the indications for adults there is also the prevention and treatment of colds and flu.

Special indications for adults:

  • chronic and acute hepatitis (A,B,C), including as monotherapy for acute hepatitis A;
  • herpes virus I and II;
  • cytomegalovirus (CMV), its complications on the liver and central nervous system;
  • encephalitis of viral etiology, as part of complex therapy (uveo and leukoencephalitis);
  • chlamydia, pulmonary and genital;
  • used in therapy for tuberculosis, as an auxiliary drug;

Amiksin in medium therapeutic doses is well tolerated by adults and children, the effect is achieved quickly if the prescribed course of treatment is followed impeccably.

Contraindications

Amiksin has a small list of contraindications, including hypersensitivity to any substances from the composition, pregnancy and breastfeeding, age up to 7 years.

There were serious allergic reactions with allergic dermatitis, Quincke's edema.

If undesirable symptoms appear after application, you should quickly contact a specialist for advice.

How to take, instructions for use

For better bioavailability, the drug is used after meals, per os (oral), drink plenty of water.

It may seem that the course of treatment is complicated, and it makes no sense to take it clearly according to the scheme, but important point just is what you need to take correctly Amiksin. Instructions for use describe that each of the indicated pathologies has a specific dose of the drug and the time for which it must be taken on a specific day. This happens because the drug reaches the organ that is sensitive to it for a certain period of time, it also takes time for the production of interferon to begin, and another time for the interferon to begin to perform its functions.

For example, the prevention of influenza and respiratory infections includes taking 125 mg for adults on the first day and then the same amount, but every two days, so that the total dose is 750 mg. For children, primary prevention is carried out in the same way, but the total dose should not exceed 180 mg.

Treatment of acute hepatitis of any viral origin with Amixin applies only to adults and includes 10 tablets in case of acute hepatitis A and 20 tablets for hepatitis B and C. So that on the first day the dose is 125 mg, and in the next 125 mg every two days.

For chronic hepatitis B and C, Amiksin is used with a total dose of a course of treatment of 2.5 g - this is 20 tablets. The course of treatment for hepatitis B lasts 3.5-6 months, and for hepatitis C - at least 6 months, it all depends on the general condition of the patient and the results of laboratory tests: blood biochemistry, serological analysis antigens and antibodies, PCR virus. The course is drawn up so that on the first day the dose is 125 mg, and in the next 125 mg every two days.

Tuberculosis, in addition to the main treatment, can be stopped by Amiksin with a dose of 2.5 g (20 tablets). The course is drawn up so that on the first day the dose is 125 mg, and in the next 125 mg every two days.

Side effects

Most often, both the child and the adult tolerate Amiksin well without any particular unpleasant adverse reactions. Rarely, dyspeptic syndrome with nausea and bloating can occur, sometimes hypersensitivity reactions and allergic reactions occur.

There have been cases of short chills and fever caused by Amiksin.

The instructions for use describe that some adverse events may affect further treatment, so it is worth consulting with your doctor and determining whether to continue the course.

Overdose

There have been no cases of overdose yet. Cases of uncontrolled intake of a large amount of the drug can lead to the appearance of new side effects or aggravation of existing ones.

Some sources indicate that cases of overdose are theoretically possible and manifest themselves in the form of an increase side effects, especially allergic reactions and autoimmune processes. In this case, it is necessary to urgently stop using Amiksin and do a gastric lavage. Anti-shock and anti-current infusion therapy is possible.

Amiksin during pregnancy

Presumably, if stimulated immune system during childbearing, there is the possibility of an autoimmune response with systemic inflammation, which further leads to miscarriage or pregnancy stagnation.

Has not been held clinical research, which would show the effect of the drug on the fetus and the condition of the pregnant woman, on the future condition of the baby. Therefore, Amiksin is considered contraindicated during pregnancy. The same is true with breastfeeding. It has been proven that the drug can pass into milk. But in what quantity, and whether it affects the child, is not yet known.

Amiksin for children

Amiksin helps to increase the activity of the bone marrow, namely, it increases the speed and frequency of stem cell division. It is not known how this may affect the body of a preschool child.

As a prevention and treatment of influenza, children after seven years of age may be prescribed Amiksin in small doses, this does not lead to any serious consequences.

Amiksin in combination with alcohol

There are no studies and clinical trials that talk about the effect of taking Amiksin together with alcohol. However, it is worth remembering that alcohol affects the ability of the intestinal epithelium to absorb nutrients that enter it. Therefore, it can, under certain circumstances, interfere with the absorption of the drug and lead to a decrease in its effectiveness.

Also, alcohol can lead to impaired liver and kidney function, which can affect the effectiveness of the drug and the reaction of the body to it.

Interaction with other substances

The drug is prescribed together with antibiotics and antimicrobials. It is believed that there is no danger of their combination and the therapeutic effect is fully achieved. But there has not been a single clinical trial that proves this. Doctors use this combination based on their own experience.

special instructions

People of intellectual professions need not worry about the negative depressing effect of Amiksin. It has not been established among its possible side effects weakness, headache and disability.

Terms of sale

Small doses of the drug prescribed for children, 60 mg each, are issued only by prescription. Adults can periodically use Amiksin without a prescription as a preventive measure. For treatment, it is necessary to take the go-ahead from the attending physician after consultation, examination and laboratory tests.

Storage conditions

The main condition is to keep children away, store at a temperature of no more than 30 degrees. The expiration date is indicated on the bank.

Similar drugs, comparison

There are many drugs with a similar mechanism of action, but inferior in clinical effect. Such drugs are prescribed in combination with others and cannot be used as monotherapy, unlike Amiksin. Among them:

  • Lavomax;
  • Tiloram;
  • Orvis imuno;
  • Kagocel;
  • Ingavirin and others.

Among the advantages of analogues, the price stands out the most. All drugs similar in mechanism of action and indications are much cheaper than Amiksin.

If you start to compare, then each drug has a separate structure, so they cannot be called completely similar. Amiksin has a therapeutic effect faster than its counterparts. It is less safe and can be given to children at an earlier age. The range of indications is wider.

Amiksin is an antiviral and immunomodulatory drug. It is effective against various infections of viral etiology, including influenza. The drug is produced by the Russian company Pharmstandard-Tomskhimfarm JSC.

Dosage form

The drug is available in 2 dosages of 60 mg (children's form) and 125 mg (adult form).

Description and composition

Children's and adult dosage forms are round, biconvex, orange coated tablets. At the break they are orange, normally you can find slight white or orange blotches.

As an active substance, a child contains 60 mg of tilorone, an adult - 125 mg.

The composition of the tablets includes the following additional components:

  • potato starch;
  • E 572;
  • povidone;
  • primellose.

The shell includes:

  • hypromellose;
  • twin 80;
  • titanium white;
  • macrogol 4000;
  • dye E 104 and E 110.

Pharmacological group

The active substance is a low molecular weight synthetic inductor. Once in the body, it stimulates the production of α, β and γ interferons by cells of the epithelium, intestines, liver, and blood. Most of all, it is produced within 4-24 hours after taking the medication.

The drug improves immunity and stops inflammation. It activates bone marrow stem cells. Depending on the dosage, the drug enhances the formation of antibodies, reduces the severity of immunosuppression, and normalizes the balance between T-suppressors and T-helpers.

Tiloron inhibits the translation of virus-specific proteins in infected cells, as a result, the reproduction of viruses is suspended.

After oral administration, the active substance is rapidly absorbed from the digestive tract, bioavailability medicinal product reaches 60%. Up to 80% of it binds to plasma proteins.

The drug is not metabolized in the body and does not accumulate. It is excreted almost unchanged mainly through the intestines (up to 70%) and only about 9% through the kidneys. The half-life is 48 hours.

Indications for use

for adults

Amiksin tablets are prescribed for the treatment and prevention of SARS and influenza.

They are also prescribed for the following diseases:

  • herpes;
  • viral hepatitis A, B, C;
  • cytomegalovirus infection.

They are prescribed in complex treatment:

  • pulmonary tuberculosis;
  • encephalomyelitis of allergic and viral etiology (including multiple sclerosis, subacute sclerosing panencephalitis, uveoencephalitis);
  • urogenital and respiratory chlamydia.

for children

Amiksin tablets can be used to treat influenza and SARS in patients older than 7 years.

for pregnant women and during lactation

The drug should not be used in patients in position and breastfeeding.

Contraindications

Amiksin tablets should not be used:

  • in children older than 7 years;
  • with individual intolerance to the composition of the drug.

Applications and doses

for adults

Tablets should be taken orally after a meal. For adults, the drug is prescribed at a dosage of 125 mg.

For children over 7 years old, the drug is prescribed at a dosage of 60 mg. for children

In the case of uncomplicated SARS and influenza, Amiksin is prescribed 1 tablet on the 1st, 2nd, and 4th day, 3 tablets are needed for the course.

In case of complicated infections, the drug should be taken on the 6th day, in total, 4 tablets are required for the course.

Side effects

While taking the medication, the following side effects may occur:

  • dyspeptic disorders;
  • allergy;
  • short chill.

Interaction with other drugs

There was no clinically significant interaction of Amiksin tablets with antibiotics and antiviral drugs.

special instructions

As part of the combined treatment of neuroviral infections, the drug should be used only under the supervision of a specialist.

Overdose

To date, not a single case of drug overdose Amiksin has been registered.

Storage conditions

Amiksin should be stored at t maximum 30 degrees, in a dry, dark place out of the reach of children. The shelf life of the tablets is 36 months.

The children's form of the drug Amiksin 60 mg can be purchased by prescription, Amiksin tablets at a dosage of 125 mg - without a prescription.

Analogues

A complete structural analogue of the drug Amiksin is. The drug is available in only one dosage of 125 mg and is approved for use in adults together with other medicines for the following diseases:

  • herpes;
  • viral hepatitis A, B and C;
  • infections provoked by cytomegalovirus;
  • inflammation of the urinary canal of non-gonococcal nature;
  • pulmonary tuberculosis;
  • chlamydia of the genital organs and respiratory tract;
  • pulmonary tuberculosis;
  • inflammation of the brain and spinal cord of a viral or infectious-allergic nature.

It is also prescribed for the treatment and prevention of influenza and other viral infections.

Both drugs differ from each other in the composition of excipients, the content of which is contraindicated not only in case of hypersensitivity to the drug, pregnancy and lactation, but also in case of glucose-galactose malabsorption, intolerance to fruit sugar, deficiency of isomaltose and sucrose.

In addition, the preparations differ from each other and the storage conditions of the tablet can be stored at a temperature of a maximum of 25 degrees. The shelf life of the drug is 24 months.

It is permissible to replace the drug Amiksin with an analogue only after consulting a specialist, since, despite the fact that Amixin contains the same active substance, there are a number of differences between the two medicines.

The price of the drug

The cost of Amiksin averages 697 rubles. Prices range from 512 to 1092 rubles.

Amiksin (INN tilorone) is an antiviral and immunostimulating drug that activates the production of immune interferon proteins. Scientific advances in the field of immunology have greatly improved the treatment strategy for many viral infections. An integral part of this strategy is the use human interferons obtained through genetic engineering. However, the widespread use of these compounds is hindered by the trail of undesirable adverse reactions. An effective alternative to the use of artificially synthesized human interferons are drugs that can stimulate the body's own synthesis of interferons. One of these drugs is Amiksin, which was created by Ukrainian scientists, and today is produced incl. and on the territory of Russia. Comprehensive studies of the drug have proven its effectiveness in the treatment and prevention of many viral infections, tk. the active component of the drug tilorone exhibits antiviral activity against a wide range of viruses and enhances the synthesis of interferon types 1 and 2. In addition, Amiksin sensitizes target cells to the action of endogenous interferon, promotes the production of the so-called. "late" interferon, controls the inflammatory response depending on its phase. Tiloron has the ability to be quickly and completely absorbed into gastrointestinal tract. The bioavailability of the drug is relatively high (especially for the oral form) and is 60%. The half-life of Amiksin is two days.

Interesting information: since 1998 and to this day, Amiksin is used for seasonal prevention of influenza and SARS among the medical staff of Moscow clinics and among ambulance teams medical care. It was found that the drug reduces the risk of infection by almost 4 times. And one more noteworthy fact: the goal of the developers of the drug was emergency treatment and prevention of severe and life-threatening viral infections, incl. during war, man-made disasters and in other force majeure circumstances. One of the indisputable advantages of Amiksin is the minimum number of side effects, the frequency of which is comparable to the statistical error. After taking the drug, the peak production of interferon falls on 4-24 hours of tilorone in the body. The tablet form and low frequency of administration increase compliance (adherence to patient treatment) and provide ease of administration. The drug is equally effective when used with both therapeutic and preventive purpose. Amiksin has excellent tolerance: during its use, not a single case of the development of individual intolerance reactions was recorded. Direct contraindications to the use of Amiksin are pregnancy, lactation and age under seven years. The drug is compatible with antibacterial agents. Cases of overdose with Amiksin have not been documented to date.

Pharmacology

Low molecular weight synthetic interferon inductor that stimulates the formation of alpha, beta, gamma interferons in the body. The main structures producing interferon in response to the administration of tilorone are intestinal epithelial cells, hepatocytes, T-lymphocytes, neutrophils and granulocytes. After taking the drug orally, the maximum production of interferon is determined in the sequence intestine-liver-blood after 4-24 hours. Amiksin ® has an immunomodulatory and antiviral effect.

In human leukocytes, it induces the synthesis of interferon. Stimulates bone marrow stem cells, increases antibody production depending on the dose, reduces the degree of immunosuppression, restores the ratio of T-suppressors and T-helpers. Effective for various viral infections (including those caused by influenza viruses, other pathogens of acute respiratory viral infections, hepatitis viruses, herpes). The mechanism of antiviral action is associated with the inhibition of translation of virus-specific proteins in infected cells, resulting in suppressed reproduction of viruses.

Pharmacokinetics

Suction

After taking the drug inside, tilorone is rapidly absorbed from the gastrointestinal tract. Bioavailability is about 60%.

Distribution

Plasma protein binding - about 80%.

Metabolism and excretion

Tiloron does not undergo biotransformation and does not accumulate in the body. It is excreted practically unchanged with feces (about 70%) and urine (about 9%). T 1/2 is 48 hours.

Release form

Orange film-coated tablets, round, biconvex; at the break - orange, slight blotches of orange or white are allowed.

Excipients: potato starch, microcrystalline cellulose, povidone (collidon 30), calcium stearate, sodium croscarmellose (primellose).

Shell composition: hypromellose (hydroxypropyl methylcellulose), titanium dioxide, macrogol 4000 (polyethylene glycol 4000), polysorbate 80 (tween 80), quinoline yellow (E104), yellow-orange sikovit 85 (E110).

6 pcs. - cellular contour packings (1) - packs of cardboard.
10 pieces. - cellular contour packings (1) - packs of cardboard.
10 pieces. - cellular contour packings (2) - packs of cardboard.
6 pcs. - polymer cans (1) - packs of cardboard.
10 pieces. - polymer cans (1) - packs of cardboard.
20 pcs. - polymer cans (1) - packs of cardboard.

Dosage

The drug is taken orally after a meal.

In adults, for nonspecific prophylaxis of viral hepatitis A, the drug is prescribed at a dose of 125 mg once a week for 6 weeks. Heading dose - 750 mg (6 tab.).

In the treatment of viral hepatitis A, the dose of the drug on the first day is 125 mg 2 times / day, then they switch to 125 mg after 48 hours. The course of treatment is 1.25 g (10 tablets).

In the treatment of acute hepatitis B in the initial phase of treatment on the first and second day, the dose of the drug is 125 mg / day, and then 125 mg after 48 hours. The course of treatment is 2 g (16 tablets).

With a protracted course of hepatitis B on the first day, the dose of the drug is 125 mg 2 times / day, then 125 mg after 48 hours. The course dose is 2.5 g (20 tablets).

In chronic hepatitis B in the initial phase of treatment, the total dose is 2.5 g (20 tab.). In the first 2 days, the daily dose is 250 mg, then they switch to 125 mg after 48 hours. mg per week. The course dose of Amiksin varies from 3.75 to 5 g, the duration of treatment is 3.5-6 months, depending on the results of biochemical, immunological and morphological studies, reflecting the degree of activity of the process.

In acute hepatitis C, on the first and second days of treatment, Amixin ® is prescribed at a dose of 125 mg / day, then 125 mg after 48 hours. The course dose is 2.5 g (20 tablets).

In chronic hepatitis C in the initial phase of treatment, the total dose is 2.5 g (20 tab.). In the first 2 days, the drug is taken at a dose of 250 mg / day, then 125 mg after 48 hours. In the continuation phase of treatment, the total dose is 2.5 g (20 tablets), while the drug is prescribed at a dose of 125 mg per week. The course dose of Amiksin is 5 g (40 tablets), the duration of treatment is 6 months, depending on the results of biochemical, immunological and morphological studies, reflecting the degree of activity of the process.

In the complex therapy of neuroviral infections - 125-250 mg / day in the first two days of treatment, then 125 mg after 48 hours. The dose is set individually, the duration of the course of treatment is 3-4 weeks.

For the treatment of influenza and other acute respiratory viral infections in the first 2 days of illness, Amixin ® is prescribed at a dose of 125 mg / day, then 125 mg after 48 hours. The course dose is 750 mg (6 tablets).

For the prevention of influenza and SARS, Amixin ® is prescribed at a dose of 125 mg once a week for 6 weeks. Heading dose - 750 mg (6 tab.).

For the treatment of herpetic, cytomegalovirus infection, the dose of the drug in the first 2 days is 125 mg, then 125 mg are taken every 48 hours. The course dose is 1.25-2.5 g (10-20 tablets).

In urogenital and respiratory chlamydia, Amixin ® is prescribed at a dose of 125 mg / day for the first 2 days, then 125 mg every 48 hours. The course dose is 1.25 g (10 tablets).

In the complex therapy of pulmonary tuberculosis in the first 2 days, the drug is prescribed at 250 mg / day, then at 125 mg after 48 hours. The course dose is 2.5 g (20 tablets).

For children over 7 years of age with uncomplicated forms of influenza or other acute respiratory viral infections, the drug is prescribed at a dose of 60 mg (1 tab.) 1 time / day after meals on the 1st, 2nd and 4th day from the start of treatment. Heading dose - 180 mg (3 tablets).

With the development of complications of influenza and other acute respiratory viral infections, the drug is taken 60 mg 1 time / day on the 1st, 2nd, 4th, 6th day from the start of treatment. Heading dose - 240 mg (4 tab.).

Overdose

To date, cases of overdose of the drug Amiksin ® are unknown.

Interaction

Clinically significant drug interactions of Amiksin with antibiotics and conventional treatment of viral and bacterial infections not found.

Side effects

From the digestive system: symptoms of dyspepsia are possible.

Other: short-term chills, allergic reactions are possible.

Indications

In adults

  • for the prevention and treatment of influenza and SARS;
  • for the treatment of viral hepatitis A, B and C;
  • for the treatment of herpes infection;
  • for the treatment of cytomegalovirus infection;
  • as part of the complex therapy of allergic and viral encephalomyelitis (including multiple sclerosis, leukoencephalitis, uveoencephalitis);
  • as part of the complex therapy of urogenital and respiratory chlamydia;
  • in the complex therapy of pulmonary tuberculosis.

In children older than 7 years

  • for the treatment of influenza and SARS.

Contraindications

  • pregnancy;
  • breastfeeding period;
  • childhood up to 7 years;
  • hypersensitivity to the drug.

Application features

Use during pregnancy and lactation

Amiksin ® is contraindicated for use during pregnancy and during breastfeeding.

Use in children

Contraindication: children under 7 years of age.

special instructions

Amiksin ® is compatible with antibiotics and conventional treatment of viral and bacterial infections.