Medicinal product acc. ACC instructions for use (powder, tablets)

ACC (ACC)

Composition

Effervescent tablets: acetylcysteine and auxiliary components (ascorbic acid, sucrose, saccharin, flavoring).

Powder: acetylcysteine and auxiliary components (sucrose).

ACC Long effervescent tablets: acetylcysteine and auxiliary components (ascorbic acid, sodium citrate, saccharin, sodium cyclamate, lactose, citric acid, sodium carbonate, mannitol, sodium bicarbonate, flavoring).

ACC for children: acetylcysteine.

pharmachologic effect

The active substance is acetylcysteine, a cysteine derivative (amino acid). It has a mucolytic, expectorant effect due to the rupture of bisulfide bonds of sputum mucopolysaccharides. This depolymerizes mucoproteins and reduces the viscosity of bronchial secretions. As a result, mucociliary clearance increases and sputum discharge improves. Acetylcysteine has an antioxidant and pneumoprotective effect, which is associated with the binding properties of sulfhydryl groups. It is an antidote for acute poisoning with aldehydes, paracetamol and phenols (the detoxifying effect is possible due to increased production of glutathione).

Acetylcysteine, when administered internally, is almost immediately completely absorbed from gastrointestinal tract. The active metabolite is cysteine, which is formed in the liver. Further, the metabolism of acetylcysteine passes through the formation of diacetylcysteine, cystine. Final product metabolism - mixed disulfides.

Bioavailability is 10%. Cmax is determined by internal use after 1-3 hours. Plasma proteins bind 50% of acetylcysteine. The maximum concentration of the pharmacologically active metabolite in the blood is 2 µmol/L.

Inactive metabolites are excreted in the urine (inorganic sulfates, diacetylcysteine), but a small amount of acetylcysteine is excreted unchanged in the feces.

The half-life of acetylcysteine depends on biotransformation in the liver. With liver failure, it is 8 hours, while normally it is 1 hour. It passes through the hematoplacental barrier and can accumulate in the amniotic fluid.

Indications for use

Acetylcysteine is prescribed in all cases of diseases with accumulation in the bronchial tree and upper respiratory tract thick viscous sputum, namely:
Acute and chronic bronchitis, including obstructive;
bronchiolitis;
tracheitis;
Bronchial asthma;
bronchiectasis;
cystic fibrosis;
Laryngitis;
sinusitis;
Median exudative otitis.

Mode of application

The daily dose for the treatment of cystic fibrosis in patients weighing more than 30 kg is used up to 800 mg. Children from the 10th day of life and up to 2 years old use 50 mg 2-3 r / s. At the age of 2-5 years - 400 mg per day, divided into 4 doses. From 6 years old - 600 mg / s (divided into 3 doses). Treatment is continued for a long time, courses for several months (3-6).
In all other cases daily dose for children from 14 years old and adults is 400-600 mg. From 6 to 14 years - 300-400 mg (divided into 2 doses), 2-5 years - 200-300 mg (divided into 2 doses). Children from the 10th day of life and up to 2 years old use 50 mg 2-3 r / s. At acute diseases without complications, the drug is prescribed for 5-7 days. In case of complications or chronic course, course treatment is possible (up to 6 months).

ACC is taken after a meal. The tablet or the contents of the sachet must be dissolved in half a glass of liquid (cold tea, water, juice).

Side effects

From the gastrointestinal tract - stomatitis, nausea, vomiting, diarrhea, heartburn.
From the side of the CNS headache, noise in ears.
From the side of the CCC - arterial hypotension, increased heart rate.

Allergic reactions - bronchospasm (especially with bronchial hyperreactivity), rash and itching of the skin. Often the cause of hypersensitivity to the drug is the presence of propyl and methyl parahydroxybenzoate in the composition.

Contraindications

Hypersensitivity to acetylcysteine and excipients
peptic ulcer
hereditary fructose intolerance
Pulmonary bleeding or hemoptysis
In pediatric practice - with hepatitis and renal failure (the threat of accumulation of nitrogen-containing products).

Pregnancy

There is no embryotoxic effect in acetylcysteine, however, during pregnancy, as well as during breastfeeding, it is prescribed only if there are indications under the supervision of a physician.

drug interaction

Tetracycline and its derivatives (except doxycycline) should not be used together with ACC in pediatrics.
During experimental studies in vitro, no cases of inactivation of other species were detected. antibacterial drugs. However, it is recommended to observe the interval between taking ACC and antibiotic at least 2 hours. In vitro, the incompatibility of acetylcysteine with semi-synthetic penicillins, aminoglycoside and cephalosporin antibiotics has been proven. Such studies have not been conducted with erythromycin, amoxicillin and cefuroxime.

Simultaneous use of antitussive drugs can lead to stagnation of the secretion of the respiratory tract.

The use of nitroglycerin may enhance the vasodilating effect of the latter.

Overdose

In pediatric practice, cases of hypersecretion in infants are described. Side effects that threaten life and health are not described. In case of overdose (dyspeptic disorders), symptomatic therapy is prescribed.

Release form

ACC 100, 200 - effervescent tablets, 20 pcs.
ACC hot drink - powder for preparing a hot drink for internal use - 200 mg (20 sachets) and 600 mg (6 sachets).
ACC-long - effervescent tablets (600 mg), 10 pcs. in a tube.
ACC powder for preparation of solution for oral intake- 100, 200 mg, 2 pcs. packaged.

ACC for children - powder for the preparation of a solution for oral administration 30 g in a 75 ml vial (20 mg / ml) and 60 g in a 150 ml vial (20 mg / ml).

Storage conditions

In places inaccessible to children. Temperature not more than 30°С. The finished solution should be stored for no more than 12 days in the refrigerator (at a temperature of 2-8°C).

Nosological classification (ICD-10)

Acute sinusitis (J01)

Acute obstructive laryngitis [croup] and epiglottitis (J05)

Bacterial pneumonia, not elsewhere classified (J15)

Acute bronchitis (J20)

Chronic sinusitis (J32)

Chronic laryngitis and laryngotracheitis (J37)

Chronic bronchitis, unspecified (J42)

For the best mucolytic effect in the treatment with acetylcysteine, you should drink plenty of fluids.

10 ml of the prepared oral solution contains 0.31 carbohydrate units, which should be noted by patients with diabetes.

Sorbitol has a slight laxative effect on the stool.

For newborns and children under 1 year of age, acetylcysteine is used exclusively for health reasons under strict medical supervision. The recommended dosage (10 mg/kg body weight) must not be changed.
ACC 200 is not used at the age of up to 2 years.
ACC Long is not recommended for children under 14 years of age.

The speed of reaction when driving and working with machinery does not change when taking acetylcysteine.

The authors

Attention!
Description of the drug ACC"on this page is a simplified and expanded version official instructions by application. Before purchasing or using the drug, you should consult your doctor and read the annotation approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide on the appointment of the drug, as well as determine the dose and methods of its use.

Instruction
by application medicinal product for medical use

Registration number:

P N015473/01-180914

Trade name of the drug:

International non-proprietary name:

acetylcysteine.

Dosage form:

effervescent tablets.

Composition:

1 effervescent tablet contains:
active substance: acetylcysteine - 200.00 mg; Excipients: anhydrous citric acid - 558.50 mg; sodium bicarbonate - 200.00 mg; sodium carbonate anhydrous - 100.00 mg; mannitol - 60.00 mg; anhydrous lactose - 70.00 mg; ascorbic acid - 25.00 mg; sodium saccharinate - 6.00 mg; sodium citrate - 0.50 mg; blackberry flavor "B" - 20.00 mg.

Description: white, round, flat-cylindrical tablets with a score on one side, with a blackberry odor. There may be a slight sulfur odor.
Reconstituted Solution: colorless transparent solution with a smell of blackberry. There may be a slight sulfur odor.

ATX code: R05CB01.

Pharmacological properties

Pharmacodynamics
Acetylcysteine is a derivative of the amino acid cysteine. It has a mucolytic effect, facilitates sputum discharge due to a direct effect on the rheological properties of sputum. The action is due to the ability to break the disulfide bonds of mucopolysaccharide chains and cause depolymerization of sputum mucoproteins, which leads to a decrease in sputum viscosity. The drug remains active in the presence of purulent sputum.
It has an antioxidant effect based on the ability of its reactive sulfhydryl groups (SH-groups) to bind to oxidizing radicals and thus neutralize them.
In addition, acetylcysteine promotes the synthesis of glutathione, an important component of the antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine increases the protection of cells from the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory reaction.
At preventive use acetylcysteine, there is a decrease in the frequency and severity of exacerbations of bacterial etiology in patients with chronic bronchitis and cystic fibrosis.

Pharmacokinetics
Absorption is high. They are rapidly metabolized in the liver with the formation of a pharmacologically active metabolite - cysteine, as well as diacetylcysteine, cystine and mixed disulfides. Bioavailability when taken orally is 10% (due to the presence of a pronounced "first pass" effect through the liver). The time to reach the maximum concentration (Cmax) in the blood plasma is 1-3 hours. Communication with blood plasma proteins is 50%. It is excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine).
The half-life (T1 / 2) is about 1 hour, liver dysfunction leads to prolongation of T1 / 2 up to 8 hours. Penetrates through the placental barrier.
Data on the ability of acetylcysteine to penetrate the blood-brain barrier and be excreted from breast milk missing.

Indications for use

Respiratory diseases, accompanied by the formation of viscous sputum difficult to separate:
acute and chronic bronchitis, obstructive bronchitis;
tracheitis, laryngotracheitis;
pneumonia;
lung abscess;
bronchiectasis, bronchial asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis;
cystic fibrosis;
Acute and chronic sinusitis, inflammation of the middle ear (otitis media).

Contraindications:

Hypersensitivity to acetylcysteine or other components of the drug;
peptic ulcer and duodenum in the acute stage;
pregnancy;
period breastfeeding;
hemoptysis, pulmonary bleeding;
lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
childhood up to 2 years (for this dosage form).

Carefully: peptic ulcer of the stomach and duodenum in history, bronchial asthma, obstructive bronchitis, hepatic and / or kidney failure, histamine intolerance (long-term use of the drug should be avoided, because acetylcysteine affects the metabolism of histamine and can lead to signs of intolerance, such as headache, vasomotor rhinitis, itching), varicose veins veins of the esophagus, diseases of the adrenal glands, arterial hypertension.

Use during pregnancy and during breastfeeding

Data on the use of acetylcysteine during pregnancy and breastfeeding are limited, so the use of the drug during pregnancy is contraindicated. If necessary, the use of the drug during breastfeeding should decide on its termination.

Dosage and administration

Inside, after eating.
Effervescent tablets should be dissolved in one glass of water. Tablets should be taken immediately after dissolution, in exceptional cases, you can leave the solution ready for use for 2 hours. Additional fluid intake enhances the mucolytic effect of the drug. With short-term colds, the duration of administration is 5-7 days. At chronic bronchitis and cystic fibrosis, the drug should be taken for a longer time to achieve a preventive effect against infections.
In the absence of other prescriptions, it is recommended to adhere to the following dosages:
Mucolytic therapy:
adults and children over 14 years of age: 1 effervescent tablet 2-3 times a day (400-600 mg);
children from 6 to 14 years old: 1 effervescent tablet 2 times a day (400 mg);
children from 2 to 6 years old: 1/2 effervescent tablet 2-3 times a day (200-300 mg).
Cystic fibrosis:
children from 2 to 6 years old: 1/2 effervescent tablet 4 times a day (400 mg);
children over 6 years old: 1 effervescent tablet 3 times a day (600 mg).

Side effect

According to the World Health Organization (WHO), adverse effects are classified according to their frequency of development as follows: very often (≥ 1/10), often (≥1/100,<1/10), нечасто (≥1/1000, <1/100), редко (≥1/10000, <1/1000) и очень редко (<1/10000); частота неизвестна (частоту возникновения явлений нельзя определить на основании имеющихся данных).
allergic reactions
infrequently: skin itching, rash, exanthema, urticaria, angioedema, lowering blood pressure, tachycardia;
very rarely: anaphylactic reactions up to anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).
From the respiratory system
seldom: shortness of breath, bronchospasm (mainly in patients with bronchial hyperreactivity in bronchial asthma).
From the gastrointestinal tract
infrequently: stomatitis, abdominal pain, nausea, vomiting, diarrhea, heartburn, dyspepsia.
Sensory disturbances
infrequently: noise in ears.
Other
infrequently: headache, fever, isolated reports of bleeding due to hypersensitivity reactions, decreased platelet aggregation.

Overdose

Symptoms: with an erroneous or deliberate overdose, such phenomena as diarrhea, vomiting, stomach pain, heartburn and nausea are observed.
Treatment: symptomatic.

Interaction with other drugs

With the simultaneous use of acetylcysteine and antitussives due to the suppression of the cough reflex, sputum stagnation may occur.
When used simultaneously with antibiotics for oral administration (penicillins, tetracyclines, cephalosporins, etc.), their interaction with the thiol group of acetylcysteine is possible, which can lead to a decrease in their antibacterial activity. Therefore, the interval between taking antibiotics and acetylcysteine should be at least 2 hours (except for cefixime and loracarbene).
Simultaneous use with vasodilators And nitroglycerin may lead to an increase in vasodilator action.

special instructions

Advice for patients with diabetes
1 effervescent tablet corresponds to 0.006 XE. When working with the drug, it is necessary to use glassware, avoid contact with metals, rubber, oxygen, easily oxidized substances.
When using acetylcysteine, cases of severe allergic reactions such as Stevens-Johnson syndrome and Lyell's syndrome have been reported very rarely. If there are changes in the skin and mucous membranes, you should immediately consult a doctor, the drug should be stopped.
In patients with bronchial asthma and obstructive bronchitis, acetylcysteine should be administered with caution under the systemic control of bronchial patency.
Do not take the drug immediately before bedtime (it is recommended to take the drug before 18.00).

Influence on the ability to drive vehicles, mechanisms

There are no data on the negative effect of the drug ACC ® 200 in recommended doses on the ability to drive vehicles, mechanisms.

Special precautions for the disposal of unused medicinal product

There is no need for special precautions when discarding unused ACC 200.
Close the tube tightly after taking the pill!

Release form

When packing Hermes Pharma Ges.m.b.H., Austria:
Primary packaging
20 or 25 effervescent tablets in a plastic tube.
secondary packaging
1 tube of 20 effervescent tablets or 2 or 4 tubes of 25 effervescent tablets with instructions for use in a cardboard box.
When packing Hermes Arznaimittel GmbH, Germany
Primary packaging
4 effervescent tablets in strips of three-layer material: paper/polyethylene/aluminum.
secondary packaging
15 strips with instructions for use in a cardboard box.

Storage conditions

In a dry place at a temperature not exceeding 25°C.
Keep out of the reach of children.

Best before date

3 years.
Do not use after the expiration date.

Holiday conditions

Without recipe.

Manufacturer

RC holder: Sandoz d.d., Verovshkova 57, 1000 Ljubljana, Slovenia;

Produced:
1. Hermes Pharma Ges.m.b.H., Austria;
2. Hermes Artsnaimittel GmbH, Germany.

Send consumer claims to ZAO Sandoz:
123317, Moscow, Presnenskaya emb., 8, building 1.

Most diseases are always accompanied by a cough, so it is understandable that there is a desire to get rid of it faster. The range of anti-influenza and expectorants is wide. How to make the right choice? Not every medication is suitable for the treatment of dry or wet cough. So ACC can not always be used.

Ass medicine is a mucolytic, expectorant and detoxifying agent, prescribed for severe coughs in children and adults. This drug is able not only to dilute sputum, but also to effectively remove it from the lungs and bronchi, relieve inflammation, and improve the functioning of the secretory motor functions of the body. The ACC instruction states that it can be used in the presence of the following deviations in the state of health:

acute or chronic bronchiolitis and bronchitis;
sinusitis;
asthma;
pneumonia;
pulmonary eczema;
tuberculosis;
otitis media;
cold.

Even this is not all the possibilities of the ACC. Due to its medicinal properties, the drug is often used for cystic fibrosis, a hereditary disease caused by a gene mutation. In addition, it is often prescribed for the treatment of mild or prolonged inflammatory processes of the nasopharynx: tracheitis, acute rhinitis, rhinopharyngitis, sinusitis, which are accompanied by the accumulation of a large amount of purulent mucus.

What kind of cough is ACC prescribed for?

If the house already has a package of the remedy, then before going to the pharmacy, you can independently study what kind of cough they drink ACC. However, complex medical terms and phrases will not be clear to everyone. Doctors recommend taking the drug with a wet productive cough - when excess viscous or too thick sputum accumulates in the bronchi.

ACC - at what age can children be given

Many young mothers ask: is it possible and from what age to give ACC to children? To which experienced pediatricians confidently answer: it is not only possible, but necessary. The main thing is to do it right:

A child from 2 years old to 6 years old can only be given ACC 100 mg, which is available as a powder.
Starting from the age of 7, treatment with ACC 200 mg is allowed. This medicine can be found in granules.
For children 14 years of age and older, ACC 600 is available. Unlike other drugs, this type of medication is valid for 24 hours.
As a syrup, medicine is allowed to be given to infants, but only under the supervision of a pediatrician.

How to use ACC

For convenience, many pharmaceutical companies began to produce the drug in several forms: granules, for example, with orange flavor, instant tablets, syrup. Each form has its own doses and framework for how to take ACC:

It is extremely rare that the solution is prescribed for inhalation. If the nebulizer used for the procedure is equipped with a distribution valve, then 6 ml of a 10% powder solution should be used. If there is no such supplement, doctors recommend taking a 20% solution at the rate of 2-5 ml per 1 liter of water.
With bronchoscopy, severe rhinitis, sinusitis, the use of ACC intratracheally is allowed. To clean the bronchi and nasal sinuses, a 5-10% solution is used. The diluted liquid must be instilled into the nose and ears up to 300 mg per day.
With the parenteral method of application, ACC is administered intramuscularly or intravenously. In the latter case, the ampoule must be diluted with sodium chloride or dextrose in proportions of 1 to 1.

ACC-long - instructions for use

The ACC agent marked long differs from ordinary tablets or powder in that the effect of exposure to it lasts not 5-7 hours, but the whole day. The medicine is produced in the form of large effervescent tablets and is intended for oral administration 1 tablet 1 time / day, in the absence of other doctor's recommendations. Additionally, along with the medicine, it is necessary to drink up to one and a half liters of liquid, which enhances the mucolytic effect.

How to breed ACC long:

Pour into a glass of clean chilled boiled water, put a tablet on the bottom.
Wait for the effervescent effect to pass and the capsule to completely dissolve.
Drink the solution immediately after dissolution.
Sometimes, before drinking ACC, the diluted drink can be left for several hours.

ACC powder - instructions for use

ACC powder is used in the following doses:

adolescents over 14 years of age and adults are prescribed up to 600 mg of acetylcysteine, the intake is divided into 1-3 approaches;
a child under 14 years of age is recommended to give the same dose of the drug, but divided into several doses per day;
babies under 6 years old can be given 200-400 mg of powder per day.

ACC powder for both adults and children should be drunk after meals, and the composition from the bag must be properly prepared. In what water to dissolve ACC depends on your preferences, but remember: the best result will be achieved if you dilute the medicine with half a glass of hot water. However, orange-flavored baby granules can be dissolved in lukewarm, boiled water.

Effervescent tablets ACC - instructions for use

Effervescent tablets of acetylcysteine are diluted with water according to the same system as regular powder. The dose of the drug, in the absence of other doctor's recommendations, is:

for colds and mild infectious diseases, adults - 1 tablet of ACC 200 2-3 times a day, for 5-7 days;
with chronic cough, bronchitis or cystic fibrosis, the drug is drunk for a longer period, and its dose for adults is 2 capsules of ACC 100 three times a day.

ACC syrup for children - instructions

Sweet ACC syrup is prescribed for children from the age of two and older, in the diagnosis of mild colds or chronic bronchitis. The medicine is taken orally, for 5 days, immediately after eating. The dosage of the syrup is chosen by the attending physician. If no recommendations have been received from the pediatrician, then the ACC will be the guide - the official instructions for use from the manufacturer, which says that you can take the medicine:

adolescents 10 ml 3 times / day;
if the child is from 6 to 14 years old, then 5 ml 3 times / day;
for babies 5 years old, the dose of the drug is 5 ml 2 times / day.

Remove the children's syrup from the vial using a measuring syringe. The device comes with medication. The instructions for using the syringe are as follows:

Press on the vial cap, turn it clockwise until it clicks.
Remove the cap from the syringe, insert the hole into the neck and press the syringe until it stops.
Turn the bottle upside down, pull the syringe handle towards you, measuring the required dose of syrup.
If bubbles appear inside the syringe, lower the plunger slightly.
Slowly pour the syrup into the child's mouth and let the child swallow the medicine. While taking the drug, children should stand or sit.
After use, the syringe must be washed without soap.

Analogue of ACC

If you are looking for a cheap analogue of the ACC cough analogue, pay attention to the following medicines:

Ambroxol, country of origin - Russia. It contains the same active ingredient and belongs to the category of mucolytic expectorants. Its price is about 40-50 rubles.
Fluimucil, country of origin - Italy. It is intended to eliminate the first signs of a cold and cough, but can be used to facilitate the discharge of a viscous secret from the nose. Its composition consists of 600 mg of acetylcysteine, citric acid, sorbitol and flavors. The price of the drug is about 300 rubles.
Ambrobene, country of origin - Germany. It is produced as a syrup, which is based on another active substance - ambroxol hydrochloride. The medicine helps to cope with a protracted, poorly expectorated cough, removes sputum from the bronchi, and softens the airways. Its price ranges from 200 to 300 rubles.

ACC price for cough

The release form not only contributed to the freedom of choice of the buyer, but also significantly influenced how much ACC costs in pharmacies. More often, its price is very reasonable, which makes the medicine affordable for every social stratum of the population. However, in different cities and pharmacies, drug prices may vary slightly. The average cost of the drug is as follows:

children's syrup - price up to 350 rubles;
granulated ACC - up to 200 rubles;
powder - 130-250 rubles;
powder with orange and honey flavor - price from 250 r.

ACC - contraindications

Contraindications to the use of ACC are as follows:

individual intolerance to the active substance;
hypersensitivity to additional components of the drug;
illness during pregnancy, during lactation, excluding artificial feeding;
duodenal ulcer and stomach;
liver failure;
history of pulmonary hemorrhage.

In addition, the drug is highly undesirable to use together with other cough syrups, bronchodilators and antibiotics containing codeine and depressing expectorant reflexes. With caution, you should drink the medicine for those who have previously been diagnosed with venous varicose veins, adrenal diseases or abnormalities in the endocrine system.

Side effects of ACC

Overdose symptoms and side effects of ACC appear as:

allergic reactions: skin itching, urticaria, dermatitis, laryngeal edema, anaphylactic shock;
deterioration of health: muscle weakness, drowsiness, ringing in the ears, rapid heartbeat, migraine;
stool disorder: severe diarrhea;
indigestion: nausea, heartburn, the appearance of a gag reflex after taking the pills.

Video: ACC abstract

ACC - reviews

Anton, 54 years old

I suffered from a cough for a long time. I can’t say that he was dry, but the sputum still didn’t come out. I decided to go to the hospital and the doctor advised me to try ACC long in effervescent tablets. I drank the course, as it was said to the instructions for the medicine - 5 days. The cough has not gone away at all, but breathing has become much easier, and sputum is already coming out of the bronchi.

Anastasia, 32 years old

At the beginning of the treatment of a wet, persistent cough, a friend advised me to try ACC powder. When I came to the pharmacy, at first I was embarrassed because of the price of the medicine. It cost somewhere around 130 rubles, which is very strange and inexpensive compared to analogues. I decided to try it anyway and was not mistaken, the cold went away in 3 days, and my breathing returned to normal.

ACC - instructions for use. How to drink effervescent tablets, powder or cough syrup for adults and children ACC - all about medicines and health on the site

Registration number: P N015474/01

Trade name of the drug: ACC®

International non-proprietary name: acetylcysteine.

Dosage form: granules for solution for oral administration (orange).

Composition:

1 sachet contains:

active substance: acetylcysteine - 100.0 / 200.0 mg;
Excipients: sucrose at 2829.5/2717.0 mg; ascorbic acid -12.5 / 25.0 mg; saccharin - 8.0 / 8.0 mg; orange flavor - 50.0 / 50.0 mg.

Description: homogeneous granules of white color without agglomerates with an orange smell.

Pharmacotherapeutic group: mucolytic agent.

ATX code: R05CB01.

Pharmacological properties

Pharmacodynamics

Acetylcysteine is a derivative of the amino acid cysteine. It has a mucolytic effect, facilitates sputum discharge due to a direct effect on the rheological properties of sputum. The action is due to the ability to break the disulfide bonds of mucopolysaccharide chains and cause depolymerization of sputum mucoproteins, which leads to a decrease in sputum viscosity. The drug remains active in the presence of purulent sputum.

It has an antioxidant effect based on the ability of its reactive sulfhydryl groups (SH-groups) to bind to oxidizing radicals and thus neutralize them. In addition, acetylcysteine promotes the synthesis of glutathione, an important component of the antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine increases the protection of cells from the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory reaction.

With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations of bacterial etiology in patients with chronic bronchitis and cystic fibrosis.

Pharmacokinetics

Absorption is high. It is rapidly metabolized in the liver with the formation of a pharmacologically active metabolite - cysteine, as well as diacetylcysteine; cystine and mixed disulfides. Bioavailability after oral administration is 10% (due to the presence of a pronounced "first pass" effect through the liver). The time to reach the maximum concentration (Cmax) in the blood plasma is 1-3 hours. Communication with blood plasma proteins is 50%. It is excreted mainly by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine). The half-life (T1 / 2) is about 1 hour, liver dysfunction leads to a prolongation of T1 / 2 to 8 hours. Penetrates through the placental barrier. There are no data on the ability of acetylcysteine to penetrate the blood-brain barrier and be excreted in breast milk.

Indications for use

Respiratory diseases, accompanied by the formation of viscous sputum difficult to separate:

acute and obstructive bronchitis;
, laryngotracheitis;
, lung abscess;
bronchiectasis;
bronchial asthma;
(COPD);
bronchiolitis, cystic fibrosis.

Acute and chronic sinusitis, inflammation of the middle ear (otitis media).

Contraindications

hypersensitivity to acetylcysteine or other components of the drug;
peptic ulcer of the stomach and duodenum in the acute stage;
hemoptysis, pulmonary bleeding;
sucrase / isomaltase deficiency, fructose intolerance, glucose-galactose deficiency;
pregnancy;
breastfeeding period;
children's age up to 2 years (for this dosage form).

Carefully:

history of gastric and duodenal ulcer, arterial hypertension, bronchial asthma, obstructive bronchitis, and / or histamine intolerance (long-term use of the drug should be avoided, because acetylcysteine affects histamine metabolism and can lead to signs of intolerance, such as headache, vasomotor rhinitis, itching), varicose veins of the esophagus, diseases of the adrenal glands.

Use during pregnancy and during breastfeeding

Mode of application

The granules should be dissolved in water, juice or iced tea and taken after meals. Additional fluid intake enhances the mucolytic effect of the drug.

With short-term colds, the duration of the course is 5-7 days. In case of long-term diseases, the course of therapy is determined by the attending physician. In chronic bronchitis, the drug should be taken for a longer time to achieve a preventive effect in infections. In the absence of other prescriptions, it is recommended to adhere to the following dosages:

Mucolytic therapy:

adults and adolescents over 14 years of age: 2 sachets of ACC® 100 mg or 1 sachet of ACC® 200 mg 2-3 times a day (400-600 mg per day);
children from 6 to 14 years: 1 sachet 3 times a day or 2 sachets 2 times a day ACC® 100 mg (300-400 mg per day). ACC® 200 mg should be taken 3 times a day for 1/2 sachet or 2 times a day for 1 sachet (300-400 mg per day);
children from 2 to 6 years: 1 sachet of ACC® 100 mg or 1/2 sachet of ACC® 200 mg 2-3 times a day (200-300 mg per day).

Cystic fibrosis:

children over 6 years: 2 sachets of ACC® 100 mg or 1 sachet of ACC® 200 mg 3 times a day (600 mg per day);
children from 2 to 6 years: 1 sachet of ACC® 100 mg or 1/2 sachet of ACC® 200 mg 4 times a day (400 mg per day);
patients weighing > 30 kg: if necessary, it is possible to increase the dose to 800 mg.

Side effect

According to the World Health Organization (WHO), adverse effects are classified according to their frequency of development as follows: very often (> 1/10), often (> 1/100,<1/10), нечасто (>1/1000, <1/100), редко (>1/10000, <1/1000) и очень редко (<1/10000); частота неизвестна (частоту возникновения явлений нельзя определить на основании имеющихся данных).

Allergic reactions:

infrequently: itching, rash, exanthema, angioedema, lowering blood pressure, tachycardia;

very rarely: anaphylactic reactions up to anaphylactic shock, Stevens-Johnson syndrome,

toxic epidermal necrolysis (Lyell's syndrome).

From the respiratory system:

rarely: bronchospasm (mainly in patients with bronchial hyperreactivity in bronchial asthma).

From the gastrointestinal tract:

infrequently: stomatitis, abdominal pain, nausea, vomiting, diarrhea, heartburn, dyspepsia.

From the sense organs:

infrequently: tinnitus.

Others:

very rarely: headache, fever, isolated reports of bleeding due to hypersensitivity reactions, decreased platelet aggregation.

Overdose

Acetylcysteine at doses of 500 mg/kg/day does not cause signs and symptoms of overdose. With an erroneous or deliberate overdose, such phenomena as diarrhea, vomiting, stomach pain, heartburn and nausea are observed.

Treatment: symptomatic.

Interaction with other drugs

With the simultaneous use of acetylcysteine and due to the suppression of the cough reflex, sputum stagnation may occur.

With simultaneous use with oral antibiotics (penicillins, tetracyclines, cephalosporins, etc.), their interaction with the thiol group of acetylcysteine is possible, which can lead to a decrease in their antibacterial activity. Therefore, the interval between taking antibiotics and acetylcysteine should be at least 2 hours (except for cefixime and loracarbef):

Simultaneous reception with vasodilators and nitroglycerin may lead to increased vasodilating action.

special instructions

When treating patients with diabetes, it must be taken into account that the drug contains sucrose.

Note for diabetic patients:

1 sachet of ACC® 100 mg corresponds to 0.24 XE.
1 sachet of ACC® 200 mg corresponds to 0.23 XE.

When working with the drug, it is necessary to use glassware, avoid contact with metals, rubber, oxygen, easily oxidized substances.

With the use of acetylcysteine, cases of severe allergic reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis (Lyell's syndrome) have been reported very rarely.

If there are changes in the skin and mucous membranes, you should immediately consult a doctor, the drug should be stopped.

Do not take the drug immediately before bedtime (it is recommended to take the drug before 18.00).

Influence on the ability to drive vehicles, mechanisms

There are no data on the negative effect of ACC® in recommended doses on the ability to drive vehicles and perform other activities that require concentration of attention and speed of psychomotor reactions.

Special precautions for the disposal of an unused medicinal product There is no need for special precautions for the disposal of an unused ACC® preparation.

Release form

3 g of granules in a bag of combined material (aluminum foil / paper / polyethylene). 20 and 50 sachets in a carton box along with instructions for use.

Storage conditions

At a temperature not higher than 25 °C.

Keep out of the reach of children.

Best before date

Do not use after the expiration date.

Holiday conditions

Without recipe.

Manufacturer

Sandoz d.d., Verovshkova 57, 1000 Ljubljana, Slovenia; Produced by: Lindopharm GmbH, Neustraße 82, 40721 Hilden, Germany. Send consumer claims to ZAO Sandoz.

Drugs of the ACC group, created on the basis of acetylcysteine, have actively entered the practice of treatment. One of them, ACC 100, the instruction recommends using for children. The number on the package indicates the dosage of the active substance. It corresponds to the minimum single dose for a child.

Forms of release and composition

ACC 100 is produced by the Austrian company Hermes Pharma Ges, Sandoz Slovenia, Salutas Pharma GmbH Germany in the form of effervescent tablets or blackberry flavored powder. Children enjoy drinking this medicine.

One aluminum tube contains 20 tablets or powders containing 100 mg of acetylcysteine.

The composition of the tablet and powder, according to the instructions, includes 100 mg of acetylcysteine, soda, mannitol, citric and ascorbic acid, blackberry flavor, sucrose.

Inclusion in soda makes the use of ACC 100 dangerous if a cough occurs in a patient with a sick stomach. And sucrose will require an increase in the dose of insulin for a patient with diabetes.

Acetylcysteine is the active ingredient of the drug.

Mechanism of action of ACC

The instruction refers the drug to mucolytic agents. This means that it is able to liquefy sputum, mucus, pus. Studies have shown the effectiveness of acetylcysteine in three ways:

liquefaction of thick secretions due to the breaking of the molecular bonds of mucosaccharides that make up mucus;
stimulation of local immunity through phagocyte cells;
antioxidant action, as an element in the fight against inflammation.

The effect is maximally manifested within an hour after ingestion, lasts up to eight hours. ACC 100 decomposes in the liver and is excreted mainly in the urine.

Indications for use

The instruction recommends the use of ACC 100 for children and adults with diseases associated with increased formation of mucus, sputum, pus. Such diseases are: bronchitis, laryngotracheitis, sinusitis, inflammation of the middle ear, bronchial asthma, cystic fibrosis.

Adverse reactions rarely occur in the form of skin rashes, nausea, headache, dyspepsia, stomatitis. Patients with bronchial asthma may experience an attack of bronchospasm.

Absolute contraindications for ACC 100 are:

lung diseases accompanied by hemoptysis;
peptic ulcer of the stomach and duodenum;
individual intolerance to the components.

for children under two years old;
during pregnancy and lactation;
in chronic diseases of the liver and kidneys.

Dosage

The dosage and course of treatment with the drug is prescribed by the attending physician. It depends on the severity of the condition, the weight of the patient, concomitant diseases.

An effervescent tablet or powder, according to the instructions, must be dissolved in half a glass of water, tea or juice before use. Drink after a meal.

The solution should be prepared only in glassware. In contact with metal and rubber, acetylcysteine is deactivated. Do not store the prepared drink for more than two hours.

ACC 100 should not be taken simultaneously with antibiotics such as penicillin, ampicillin, erythromycin, tetracycline, and antitussives. Because it reduces their effect. Between ingestion of an antibiotic and ACC 100, at least two hours should pass.

The tube with ACC 100 tablets must be closed quickly, because acetylcysteine partially decomposes in air.

Before starting treatment, carefully read the instructions for the preparation of the drink. All unexpected drug reactions should be reported to the doctor.

"ACC" for cough: instructions for use. "ACC 200": reviews, price

Quite often, doctors prescribe their patients the drug "ACC" ("ACC") for coughing. Instructions for the use of this remedy, as well as its contraindications, indications and side effects will be presented in this article. In addition, we will tell you about the form in which the said medicine is produced, what patients say about it, how much it costs, and so on.

Packaging of the drug, its form of release, composition

Do you know in what form the ACC (ACC) cough medication is produced? The instructions for use inform us that this drug is produced in two different forms. Let's consider them in more detail:

Medication "ACC" - powder (granular), intended for the preparation of a solution. This medicine should only be taken orally. One 3 gram sachet of powder may contain 200, 100 or 600 mg of acetylcysteine. There are 10, 6 or 20 sachets in a carton box.
The drug "ASS" - effervescent tablets. Aluminum or cardboard tubes can contain 20, 10, 100 or 50 pieces. One tablet contains 600, 200 or 100 mg of acetylcysteine. As for the auxiliary components, they include citric anhydride, sodium bicarbonate, ascorbic acid, mannitol, lactose anhydride, sodium citrate, blackberry flavor and saccharin.

Pharmacological action of the drug

What is the "ACC" ("ACC") cough remedy? Instructions for use states that it is a mucolytic drug. Due to the fact that there are sulfhydryl groups in the structure of the acetylcysteine molecule, this causes a break in the disulfide bonds of mucopolysaccharides (acidic) sputum. As a result of this exposure, the patient noticeably reduces the viscosity of mucus.

The drug in question has a mucolytic effect, and also facilitates the discharge of sputum due to a direct effect on its rheological properties. This tool retains its activity even in the presence of purulent mucus.

The medicine "ACC", the instruction of which is presented below, is very often used for prophylactic purposes. In this case, there is a decrease in the severity and frequency of exacerbations in patients with cystic fibrosis and chronic bronchitis.

Pharmacokinetics of the drug

What are the pharmacokinetic properties of the drug "ASS"? The manual does not contain such information. This is due to the fact that pharmacokinetic studies of this medication have not been conducted.

The drug "ACC": indications

The drug in question is prescribed for the following deviations:

acute and chronic sinusitis;
diseases of the respiratory system, which are accompanied by the formation of difficult and viscous sputum (for example, with bronchiectasis, acute and chronic bronchitis, cystic fibrosis, obstructive bronchitis, pneumonia, bronchial asthma and bronchiolitis);
otitis media.

Contraindications

In the presence of any deviations, in no case should the medical preparation "ACC" (powder and effervescent tablets) be prescribed? The following conditions are contraindications to the use of this remedy:

It should also be noted that this medication is prescribed with extreme caution to patients with varicose veins of the esophagus, diseases of the adrenal glands, renal and / or liver failure.

Mode of application

How should I take ACC for cough? The instructions for use contain the following instructions in this regard. Adolescents and adults are prescribed 200 mg three times a day. Children from 6 to 14 years of age should take the medicine 100 mg three times a day. For babies from 2 to 5 years old, the medication is prescribed 1 tablet (100 mg) twice a day. With such a deviation as cystic fibrosis, a child over 6 years old is given 2 tablets of the drug (100 mg each) three times a day. As for babies from 2 to 6 years old, they should take the medication 100 mg four times a day.

Patients weighing more than 30 kg with cystic fibrosis can increase the dosage to 800 mg per day.

With colds of a short-term nature, the duration of therapy with the presented medication is 5-7 days. In cystic fibrosis and chronic bronchitis, the remedy must be used for a longer time (to prevent infections).

How should I take the medicine "ACC 200"? The instruction states that this drug should be used only after meals (in order to avoid negative effects on the gastric mucosa). It should be especially noted that additional fluid intake enhances the mucolytic effect of the drug.

Before use, effervescent tablets must be dissolved in half a glass of plain water. The prepared solution should be used immediately. In exceptional cases, it can be left for 2 hours.

Overdose

With a deliberate or erroneous overdose of the drug, the patient experiences such signs as vomiting, stomach pain, diarrhea, heartburn and nausea. To date, no severe and life-threatening side effects have been observed.

drug interaction

What happens if you take any medications and the ACC remedy at the same time? Reviews of experts say that combined treatment can cause a number of undesirable reactions. Let's consider them a little further.

With the simultaneous use of acetylcysteine and other antitussives, mucus stagnation dangerous to health may occur (due to suppression of the cough reflex).

During the simultaneous administration of nitroglycerin and acetylcysteine, there is a possibility of enhancing the vasodilating effect of the former.

There is a synergism of acetylcysteine with the simultaneous use of bronchodilators.

Acetylcysteine is able to reduce the absorption of penicillins, cephalosporins and tetracyclines. In this regard, they must be taken orally 2 hours after taking the first one.

Acetylcysteine is not compatible with antibiotics such as Penicillin, Erythromycin, Cephalosporin, Tetracycline and Amphotericin, as well as proteolytic enzymes.

When acetylcysteine comes into contact with rubber and metal, sulfides are formed, which have a characteristic odor.

special instructions

With obstructive bronchitis and bronchial asthma, the drug in question should be prescribed with extreme caution. This requires systematic monitoring of bronchial patency.

If after taking the medication the patient develops side effects, then it is necessary to stop taking the remedy and immediately consult a doctor.

When treating patients with diabetes, it should be taken into account that 1 effervescent tablet corresponds to 0.006 XE.

To date, there is no information about the negative effect of the drug (in recommended dosages) on the ability to drive a car, as well as perform other activities that require special concentration of attention.

Shelf life and storage methods

The drug in question should be stored only in a dry place and out of the reach of small children. In this case, the air temperature should not be higher than 25 °C. The shelf life of the drug is three years. After this time, the use of the drug is prohibited.

After taking an effervescent tablet, the plastic or aluminum tube must be tightly closed.

Price and analogues of the drug

The price of an ACC tablet may vary, depending on the pharmacy chain, as well as on the markup on the product. However, on average, such a medicine costs about 75-150 Russian rubles. The price of granular powder is similar to effervescent tablets.

What can replace the agent in question? Pharmacy chains have a huge number of analogues of the drug, as well as drugs with a similar effect (expectorant, mucolytic). Among the most popular, I would like to highlight the following medicines: "Acestin", "Acetylcysteine", "Vicks Active ExpectoMed", "Mukobene", "Mukomist", "Mukoneks", "N-AC-Ratiopharm", "Fluimucil", "Exomyuk 200" , "Atsestad", "Lazolvan", "Ambrobene", "Ambroxol", "Mukosol", "Bronkatar", "Solvin", "Bromhexine", "Gedelix", "Mukaltin", "Prospan", "Stoptussin", " Ascoril", "Linkas" and others.

Patient reviews about the medical device

Now you know what analogues the ACC drug has and what its price is. Tablets and powder for preparing a solution quite effectively cope with the task. This is the opinion of most patients. The drug quickly treats acute and chronic sinusitis, as well as other respiratory diseases. Thanks to him, viscous and difficult to separate sputum easily moves away from the bronchi, significantly improving the condition of a sick person.

It should also be noted that the tool in question has not only high efficiency, but also a relatively inexpensive cost. This fact is very pleasing to patients who cannot afford to purchase expensive drugs.

ACC cough instructions for use and dosage

For children, if it is difficult for them to separate sputum, as well as with a wet cough, ACC is prescribed for coughing. Instructions for use and dosage of the drug are described below in the article.

ACC for cough - instructions for use and rules for admission

The drug ACC is produced in several forms, namely, in two. The first of them is a granule in a bag. ACC 100 solutions are prepared from them. The second is produced in a bottle and a syrup is prepared. The second type appeared on the market. It is more preferable for children aged from ten days of life to two years. Although the active chemicals are exactly the same.

Yandex.Direct

ACC cough for children is prescribed by a doctor in the presence of a wet cough. That is, when viscous mucus forms in the bronchi, and it is not able to move away on its own. ACC cough instructions for use indicate the following indications:

1. the presence of acute or chronic bronchitis;

2. bronchiolitis;

3. obstructive bronchitis;

4. bronchial asthma;

7. pneumonia;

8. chronic or acute sinusitis;

9. chronic obstructive pulmonary disease;

10. prophylactic reception after complications during operations;

11. paracetamol poisoning.

Pharmacological groups of the drug ACC - a means of detoxification (contains antidotes). Stimulates the motor function of the respiratory tract.

ACC for cough - dosage for use

Application and dosage of ACC: infants from the 10th day of life and children under two years of age take 2.5 ml of syrup. Or acetylcysteine fifty mg two to three times a day (daily dose of one hundred and fifty mg). Children from two to six years old - 5 ml of syrup or (acetylcysteine one hundred mg 2-3 times a day, three hundred mg per day); children from six to fourteen years old - 5 ml or (200 mg of acetylcysteine 2-3 times a day, four hundred mg). Make sure your child takes plenty of fluids throughout the day. The last dose of medication should be no later than four hours before bedtime.

The course of treatment is from five to seven days. In severe forms, the course of treatment for ACC for coughing is determined by the doctor. ACC syrup is designed for 1 course of treatment.

Side effects of ACC: possible nausea, heartburn, vomiting, noise or ringing in the ears, urticaria.

"ACC" for children (syrup): instructions for use, reviews

When a child falls ill in the family, all the attention of adults is focused on him. And the point here is not whether it is a serious disease or a cold with a cough. Moreover, in fact, the cough itself is a symptom of the disease and requires treatment.

To combat this problem, a lot of different medicines have been developed in a variety of forms: tablets, suspension, inhalation formulations, cough syrup. "ACC" for children was developed by manufacturers in Germany and Slovenia. The main functions of this drug are the thinning of sputum that is difficult to separate, facilitating the process of removing it from the respiratory tract. "ACC" has an anti-inflammatory effect, suppressing pathogens that develop in sputum.

How ACC works

For the stable functioning of the human body, nature arranged everything in such a way that a special mucous secret is constantly produced in the respiratory tract, the main functions of which include a protective, cleansing and antibacterial effect. If a person falls ill, the process of producing this secret is repeatedly activated. The consistency of this mucus has an increased viscosity: the child suffers from prolonged bouts of coughing, suffocates, and sputum does not go away. Such a cough is called unproductive.

It is in such cases that, in order to help the children's body, "ACC" is prescribed for children (syrup). Instructions for use allows you to assign it to children from the age of two. The viscosity of sputum directly depends on the presence of special bonds in it - disulfide bridges. "ACC", getting into the child's body, affects these compounds and contributes to their rupture. The sputum becomes less viscous, and the process of removing it from the respiratory tract is greatly facilitated. Air masses, getting into the bronchi, are able to circulate freely without causing irritation of the nerve endings. The cough becomes productive.

"ACC" (syrup for children) continues to be active even in cases where there is a purulent component in the sputum. At first, parents may feel that the cough has intensified. However, the strengthening of this process only indicates that the drug is working. Gradually, the cough reflex fades, soon the cough disappears completely.

The antioxidant properties of "ACC" are able to suppress local inflammatory processes, which practically negates the likelihood of relapses and complications. The drug has no effect on the immune system.

Possible release forms

For convenience and breadth of application, manufacturers offer the drug in several forms of release. The granules in the vial are diluted with water on their own, it turns out "ACC" syrup. Instructions for use for children often allow even those babies who have not yet reached the age of two to be treated with this medicine. True, doctors do not practice its appointment to newborns for the treatment of coughs and bronchitis, for the reason that the airways in infants are very narrow, and the pectoral muscles are still weak. For these reasons, a small child simply will not be able to cough up the increased amount of sputum. If there is no alternative to this medication, then treatment with ACC should be under the supervision of the attending doctor.

However, it should be noted that "ACC" (syrup) instructions for use for children under one year old allows you to prescribe if the child has cystic fibrosis (a hereditary disease characterized by impaired functioning of the respiratory system).

Effervescent tablets "ACC" are widely used. They can be purchased in three dosages: 100, 200 and 600 mg of acetylcysteine (the main active ingredient). A dose of 600 mg bears the trade name ACC-Long, is characterized by a prolonged effect and is prescribed to patients at least 14 years old. One tablet of this medication, taken once, replaces several doses of smaller doses.

The suspension is prepared by diluting granules from sachets (100, 200 mg) in water, tea, milk or juice. The resulting composition should not be hot. Ideally, if its temperature is close to body temperature.

With the use of "ACC" it is even possible to make inhalations. 1-2 ml of a solution intended for injection (used in very severe cases in a hospital under medical supervision) is mixed with isotonic sodium chloride solution and used in special inhalers or nebulizers. Procedures can be carried out 1-2 times a day. The course of therapy is up to 10 days.

Indications for use

The indications for which the appointment of this drug is possible are quite wide. As for small patients, a special dosage has been developed for them, called "ACC 100". Instruction for children syrup (as the optimal form for the treatment of even infants and children under 2 years old) allows you to use it for a number of diseases of the respiratory system.

In general, "ACC" is prescribed to patients suffering from bronchitis (any form: chronic, acute, obstructive), pneumonia, tracheitis, bronchitis (inflammatory processes of the lower respiratory tract), cystic fibrosis. The medication is used for bronchial ecstasy (an increase in the diameter of the bronchi in the place where the bronchial wall is damaged).

It is also practiced to prescribe "ACC" in the treatment of otitis media and sinusitis (acute, chronic form), since the drug is able to thin not only sputum, but also accumulations of pus, stimulating its excretion from the body.

Contraindications for taking "ACC"

"ACC" for children (syrup) instructions for use prohibits patients with individual intolerance to the components of the drug and those who suffer from peptic ulcer of the stomach and duodenum (acute stage). The same diseases, but in remission, can also respond to the use of ACC. Therefore, patients with such problems should be attentive to their well-being.

With great caution, "ACC" (syrup for children) should be taken by patients with renal and hepatic insufficiency, if there are problems with the adrenal glands, and with bronchial asthma.

Since many diseases have become younger today, even in small children, gastrointestinal ulcers or diabetes mellitus can be found. With the latter disease, it must be borne in mind that ACC contains sucrose. If a child is diagnosed with phenylketonuria, then for the treatment of cough, you should choose "ACC", which does not include aspartame (sweetener).

A contraindication for ACC Long is the age of the child under 14 years of age.

Methods of application and dosage

Instructions for the use of "ACC 100" for children, syrup is recommended for admission when the patient's age is from 2 to 5 years. It can also be granules in sachets (volume - 100 mg), which are taken 2-3 times a day. Another option is granules in a bottle for making syrup, which is indicated for taking 5 ml (1 scoop) also 2-3 times during the day after meals.

Patients in the age group from 6 to 14 years old practice the appointment of "ACC" 200 mg (granules in sachets) twice a day or 2 scoops (10 ml) of syrup twice a day with meals.

Patients over 14 years old practice the appointment of "ACC" 2 scoops (10 mg) 2-3 times a day (or use "ACC Long").

In the most extreme cases, it allows the use of "ACC" (syrup) instructions for use for children under one year old. Reviews of physicians in this case speak of an underdeveloped respiratory system and weak pectoral muscles. It will be difficult for a small child to cough up an increased amount of sputum.

It is worth saying that the standard treatment regimen is described above. In some particularly severe cases, the dosage of the drug may be adjusted upwards (or decreased if the situation is not very severe). The usual course of treatment is up to 7 days. Only a doctor can decide to increase the treatment period. In chronic forms of bronchitis or cystic fibrosis, the course of therapy with the use of ACC can last for several months. In parallel with this, constant monitoring of the functioning of the liver, kidneys, and adrenal glands is carried out. Blood enzyme parameters are also subject to control.

Possible side effects

Side effects of the drug "ACC" causes quite rarely. Parents of young patients talk about the appearance of headaches, the development of stomatitis, tinnitus. Much less often there are deviations in the functioning of the gastrointestinal tract, such as nausea, vomiting, diarrhea.

Also among the possible negative manifestations in the process of using ACC for children (syrup), the instructions for use report the risk of lowering blood pressure, the development of tachycardia (rapid heartbeat), bronchospasm, and the appearance of urticaria.

In the event of any negative reactions during therapy with the use of ACC, it is necessary to stop taking the medication and consult a pediatrician without fail.

Exceeding the permissible dosage

An overdose of the drug "ACC" can occur in several cases. It is possible for a child to take a dose calculated for an adult patient, to use a medication in an overestimated amount without special instructions from a doctor, or to accumulate it (“ACC”) in the body, which is possible with a long course of treatment without proper monitoring of the state of the liver, kidneys, blood counts. In any case, the possible reactions of patients to "ACC" (for children - syrup), instructions for use describe such manifestations as a drop in blood pressure, nausea, vomiting, a feeling of dry mouth. There is also a possibility of allergic dermatitis, accompanied by a rash and itching, bronchospasm may develop.

In especially severe cases, doctors talk about the possibility of Quincke's edema and shock.

Interaction with other drugs

All information about possible drug interactions is contained for "ACC" (syrup) instructions for use. For children from one year old, it can be taken only in the most extreme cases and under the supervision of a doctor. Although with the parallel use of "ACC" with something else, there is a danger for patients of any age.

There is information about the incompatibility of the main active ingredient "ACC" with semi-synthetic penicillins, cephalosporins, aminoglycosides. On the contrary, there is no information on the incompatibility of acetylcysteine with antibacterial drugs such as Amoxicillin, Erythromycin and Cefuroxime.

What should you pay attention to?

As mentioned earlier, for the treatment of patients from 2 to 5 years old, doctors usually prefer the drug ACC 100 (syrup). Instructions for use for children, reviews of children's doctors warn parents about the inadmissibility of the joint use of ACC and any antitussive medicines. With such a parallel intake, "ACC" dilutes sputum, and antitussive drugs suppress the cough reflex, sputum is not expectorated. This is fraught with stagnation of sputum, which seriously threatens the health, and sometimes the life of the child.

Pediatricians also do not prescribe "ACC" along with antibacterial agents, since they may be incompatible. Only a few types of tetracycline, penicillin and cephalosporin antibiotics can be used in conjunction with ACC at intervals of at least 2 hours between doses.

It is permissible to dilute ACC granules and powders on your own only in glassware. It is recommended to avoid contact with rubber or metal.

When treating with the use of "ACC", it is required to increase the amount of fluid consumed. This will significantly enhance the mucolytic effect of the drug. Children should take "ACC" no later than 4 hours before bedtime.

The opinion of consumers about the drug

Parents of patients are satisfied with the drug "ACC" (syrup). Instructions for use for children (consumer reviews confirm this fact) gives clear instructions on how to use the drug, dosage. Cough in children usually becomes productive very quickly and disappears in 3-4 days. That is, the remedy is effective in almost 100% of applications.

The syrup has a pleasant orange flavor, so even the most capricious patients do not have to be forced to take the medicine for a long time. In addition, the cost of "ACC" is available to a wide range of consumers with a wide range of financial capabilities. The tool is very convenient in storage, it will not be difficult to take it with you on the road.

ACC, of course, has certain contraindications and side effects, but using it only as prescribed by the attending physician and following all the recommendations will relieve most of the unpleasant consequences and manifestations.

The child will breathe deeply and calmly, and parents will not worry about his well-being.