How and at what pressure to take Andipal? Andipal-in: instructions for use From the pressure of the tablet, the list of drugs Andipal.

Combined drug, which has a vasodilating, antispasmodic, sedative and analgesic effect, is Andipal. Instructions for use prescribes to drink tablets with high rates pressure. Patient reviews and doctors' recommendations indicate at what pressure it is necessary to drink this drug.

Release form and composition

Andipal is available in the form of tablets for oral administration. The drug consists of papaverine hydrochloride (20 mg), metamizole sodium (250 mg), bendazole (20 mg) and phenobarbital (20 mg).

pharmachologic effect

Combined drug that has a vasodilating, analgesic and analgesic effect. A good antispasmodic, which leads to the use of Andipal from pressure.

Metamizole sodium, which is part of the composition, reduces body temperature and anesthetizes. Once in the gastrointestinal tract, the substance is well and quickly absorbed and blocks the prostaglandin system from arachidonic acid, increases the sensitivity threshold of pain centers in the hypothalamus.

Phenobarbital exhibits its sedative properties, enhances the effect of other components of the drug.
Bendazole is an antispasmodic, dilates blood vessels, stimulates the spinal cord, restores nerve endings in the periphery.
Papaverine hydrochloride dilates blood vessels (reduces the level of calcium in cells) located on the periphery and significantly lowers the overall tone of the smooth muscles of the surface internal organs.

What helps Andipal?

Indications for the use of the drug include:

Pain associated with spasms of cerebral vessels of the head.
Migraines of various types.
The medicine helps pain syndrome caused by spasms of smooth muscles or internal organs of the gastrointestinal tract.
Pressure pills can be drunk with mild forms of hypertension.

At what pressure should the medicine be taken? With primary or secondary hypertension, Andipal can be taken for high blood pressure.

Instructions for use

Andipal must be taken orally. The dosage for adults is 1 tablet 2-3 times a day. The course of treatment should not exceed 1 week-10 days.

In the event that the use of the drug does not have the necessary therapeutic effect, it is necessary to consult a doctor and choose another treatment regimen. In some cases, it may be necessary to combine Andipal with other drugs to achieve a pronounced therapeutic effect.

Contraindications

Contraindications to the use of Andipal are:

Side effects

allergic reactions;
nausea;
constipation;
decrease in blood pressure;
decrease in the speed of psychomotor reactions;
impaired liver or kidney function;
leukopenia, agranulocytosis;
drowsiness.

Children, during pregnancy and lactation

Contraindicated during pregnancy and lactation ( breastfeeding). The drug is not prescribed in children under 8 years of age.

special instructions

With prolonged (more than 7 days) use, it is necessary to control the pattern of peripheral blood and the functional state of the liver. Alcohol intake is prohibited.

drug interaction

The use of astringents, enveloping agents, activated carbon, reduce absorption in the gastrointestinal tract.

When combined with other antispasmodics and sedatives, the hypotensive effect of the drug is enhanced. The hypoglycemic activity of diabetes drugs is increased. Enhances the action of glucocorticosteroids, indomethacin and ethanol. Reduces the concentration of cyclosporine in the blood.

Inducers of microsomal liver enzymes (barbiturate, phenylbutazone), analeptics (camphor, cordiamine), tonics (eleutherococcus, ginseng root) reduce the effectiveness of the drug.

Andipal's analogs

Analogues have antispasmodic properties:

Theodibaverin.
Unispaz.
No-shpalgin.
Nomigren.
Papazol-UBF.

Terms and conditions of storage

It must be stored in a dry, dark place at a temperature not exceeding +25 °C. Keep away from children. Shelf life - 2 years 6 months.

Holiday conditions and price

The average price of Andipal (tablets No. 10) in Moscow is 20 rubles. In Kyiv, you can buy medicine for 18 hryvnia, in Kazakhstan - for 520 tenge. Pharmacies in Minsk offer the drug for 7.2 Belarusian rubles. rubles. Released without a prescription.

Post Views: 726

Read the instructions for the use of analogues:

At what pressure to drink Anaprilin: instructions, prices and reviews

When prescribing the drug Andipal, the instructions for use are necessary for mandatory study in order to identify the presence or absence of contraindications for its use and possible side effects.

Pharmacological properties

Medication Andipal is a complex vasoconstrictor, antispasmodic and analgesic agent. Andipal refers to drugs groups of narcotic analgesics and inherently does not cure hypertension, but has an antihypertensive effect.

The active substances papaverine hydrochloride and bendazole, which are part of Andipal, contribute to the expansion of the lumen of blood vessels, make smooth muscles more supple. Metamizole sodium, or analgin, lowers fever and relieves and eliminates pain.

As an antispasmodic, Andipal is used to eliminate spasms of vascular smooth muscles. Phenobarbital, also included in the composition, depresses the nervous system and increases the effectiveness of each component of the drug.

Andipal has good absorption in the gastrointestinal tract (several minutes after application). The maximum concentration of the drug is reached 20 minutes after ingestion. It is cleaved by the liver and has a long excretion by the kidneys. It is not recommended to violate the prescribed dosage medicinal product. Also, the medication has the following effect: relieves headaches, relieves pain during spasms of the intestines, stomach and other organs.

Composition and form of release

The composition of the drug Andipal includes the following active substances that make it so multifunctional.

1 tablet contains:

metamizole sodium 0.25 g.
phenobarbital 0.02 g
bendazol 0.02 g
papaverine hydrochloride 0.02 g.

Additional substances:

steatite 0.007 g
octadecanoic acid 0.003 g
starch 0.046 g
calcium salt 0.004 g

The combination of active substances included in the composition has an effective multiple effect.
Medication Andipal is produced in the form of tablets in blister plates of 10, 30 and 100 pcs. in cardboard packages.

What doctors say about hypertension

Doctor of Medical Sciences, Professor Emelyanov G.V.:

I have been treating hypertension for many years. According to statistics, in 89% of cases, hypertension ends with a heart attack or stroke and the death of a person. Approximately two-thirds of patients now die within the first 5 years of disease progression.

The next fact is that it is possible and necessary to bring down the pressure, but this does not cure the disease itself. The only medicine that is officially recommended by the Ministry of Health for the treatment of hypertension and is also used by cardiologists in their work is this. The drug acts on the cause of the disease, making it possible to completely get rid of hypertension. In addition, within the framework of the federal program, every resident of the Russian Federation can receive it IS FREE.

Indications for use

The drug Andipal is used as an analgesic in order to remove pain due to vasospasm. Andipal is recommended to be taken in the following cases:

eye pain.
urination disorders.
primary arterial hypertension.
hypertensive disease.
encephalopathy.
headaches, incl. after trauma.
chest pain, etc.

Important! An agronomist from Barnaul with 8 years of experience in hypertension found an old recipe, set up production and released a remedy that will once and for all save you from problems with pressure ...

Before starting a course of treatment, you should consult a doctor. The dosage of the drug Andipal and the duration of the course of therapy depends on the state of health of the patient and is determined individually for each patient by a specialist.

Andipal is taken orally in the following dosages:

When high blood pressure to relieve symptoms, Andipal is prescribed for 1 tablet per day.
In the case when it is not required to lower the pressure, but headaches are bothering, appoint 2 tablets per day with an interval of 1 hour. The maximum possible daily dose is not more than 5 Andipal tablets.
In case of manifestation of vegetovascular disorders, it is prescribed according to 1 tablet 2 times a day for three days. It is advisable to use motherwort in combination with Andipal or to provide a more effective effect.

Contraindications

hepatic and kidney failure.
hepatic porphyria.
lack of glucose-6-phosphate dehydrogenase.
disorders of the circulatory system.
children under the age of 18.
period of pregnancy and lactation.
individual intolerance to individual components of the medication.
intestinal obstruction.
narrow angle glaucoma.

Andipal during pregnancy and breastfeeding

The use of Andipal is categorically contraindicated in children, pregnant women and lactating women. Phenobarbital has a negative effect on the intrauterine development of the fetus, and even a small dose of the drug can provoke the pathological development of the fetal brain. There is an increased chance of having a child with cerebral palsy. During breastfeeding, Andipal is also not recommended for use, because. negatively affects the development of the child and spoils breast milk. In cases of extreme need for the use of Andipal, the child should be transferred to artificial feeding to avoid negative consequences.

Alcohol compatibility

Like others medications, Andipal is incompatible with alcoholic beverages, because it has the peculiarity of increasing the effect of ethyl alcohol on the body, which can cause side effects or death.

The use of Andipal, like any other medicine, can have side effects on the human body, namely:

Attacks of nausea, vomiting.
Interruptions in the digestive tract.
Pathologies of coagulation of protein components of blood in case of bleeding.
Depression, drowsiness, lethargy.
Allergy, various skin rashes.
Diarrhea, constipation.
Decrease in the level of leukocytes in the blood.

In the event of the manifestation of the above symptoms, you should immediately consult a doctor to provide the necessary assistance, review the dosage of the medication or replace it with another one.

Overdose

In the case when the maximum possible dose of the drug per day was exceeded, the following symptoms are observed in patients:

dizziness.
drowsiness.
lethargy.
muscle weakness.

If symptoms of an overdose of the drug are detected, the stomach should be immediately washed out and absorbent drugs should be taken. You should consult a doctor to determine the degree of overdose and further treatment of its symptoms in order to minimize them.

special instructions

Before starting a course of treatment, it is necessary to talk with the doctor about the development of situations that certain drug effects can lead to. There are cases when Andipal effectively treated migraine, when the pressure indicators were in the values of 155 to 55 (that is, low blood pressure) and returned these indicators to normal. Also read about the rate of indicators blood pressure. . In such cases, the upper pressure decreases, and the lower one, on the contrary, increases.

Andipal includes phenobarbital, therefore, the drug belongs to soft drugs, tends to be addictive. Therefore, the course of therapy is not long. Under normal conditions, Andipal shows its effectiveness during the first three days. If this does not happen, you should consult a doctor to cancel Andipal and select another drug.

In exceptional cases, Andipal can be prescribed to children and adolescents, but its intake is carried out exclusively under the supervision of the attending physician.

Interaction of Andipal with drugs

The complex use of Andipal with other drugs can enhance its antihypertensive effect on the human body. These drugs are:

Adrenoblockers.
Diuretic drugs.
Blockers of slow calcium channels.
Nitrates.
Myotropic antispasmodics.

The opposite effect, that is, a decrease in the antihypertensive effect, occurs when taken in parallel with drugs of such groups:

Analeptics.
Tonics.
Anticholinesterase agents.
Adrenergic receptor agonists.

In accordance with the instructions for use, taking Andipal and drugs from the group of narcotic analgesics leads to the appearance side effects. In combination with activated charcoal, Andipal is poorly absorbed from the gastrointestinal tract, tk. the absorbent effect of coal does not allow the active substances of Andipal to pass into the stomach and intestines. Analdim

Papazol

Urolesan

Before replacing Andipal with an analogue, you should consult a doctor for possible adjustment of the prescribed dose and in order to avoid side effects of the drug.

The price of Andipal

The price of the drug Andipal varies depending on the manufacturer, the place of purchase of the drug, dosage and form of release.

Company manufacturer	The number of tablets in a pack.	Average price in Russia
Dalchimpharm, Russia	10 pieces.	8 rub.
Pharmstandard, Russia	10 pieces.	10 rub.
Pharmstandard, Russia	20 pcs.	29 rub.
Irbitsky KhPZ	10 pieces.	19 rub.
Irbitsky KhPZ	20 pcs.	37 rub.
Anzhero-Sudzhensky KhPZ	20 pcs.	65 rub.

The table shows the average prices for Andipal. The price of the drug must be specified directly at the place of purchase.

The combined drug has a vasodilatory, analgesic, antispasmodic and sedative effect.

Release form

10 pieces. - non-cell packing contour.

Dosage

Inside, 1 tablet 2-3 times / day.

Interaction

Enhances the hypotensive effect of nitrates, slow calcium channel blockers, beta-blockers, ganglion blockers, diuretics (including furosemide, hypothiazide), myotropic antispasmodics.

Mutual increase in the risk of side effects when used simultaneously with narcotic analgesics.

Adsorbents, astringents, enveloping drugs reduce the absorption of the drug from the gastrointestinal tract.

Side effects

Allergic reactions, drowsiness, decreased rate of psychomotor reactions, nausea, constipation, decreased blood pressure, leukopenia, agranulocytosis, impaired liver / kidney function.

Indications

Pain syndrome associated with spasm of peripheral arteries, smooth muscles of the gastrointestinal tract, cerebral vessels; arterial hypertension.

Contraindications

Hypersensitivity, severe renal / hepatic failure, deficiency of glucose-6-phosphate dehydrogenase, blood diseases, tachyarrhythmia, severe angina pectoris, decompensated chronic heart failure, angle-closure glaucoma, prostatic hyperplasia, intestinal obstruction, megacolon, pregnancy, lactation, childhood(up to 8 years).

Application features

Use during pregnancy and lactation

Contraindicated in pregnancy and lactation (breastfeeding).

Application for violations of liver function

Contraindicated in severe liver failure.

Application for violations of kidney function

Contraindicated in severe renal failure.

Use in children

Contraindicated in children under 8 years of age.

special instructions

With prolonged (more than 7 days) use, it is necessary to control the pattern of peripheral blood and the functional state of the liver.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment, it is necessary to refrain from engaging in potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Some facts about the product:

Instructions for use

Price in the online pharmacy site: from 24

Pharmacological properties

Andipal belongs to the group of painkillers, antipyretics. This medicine of the combined composition has an analgesic effect. An effective antispasmodic dilates blood vessels, therefore it is successfully used to lower blood pressure.

One of the components of Andipal - metamizole sodium, widely known as analgin, exhibits a pronounced antipyretic, analgesic effect, eliminates spasm of the smooth muscles of the urinary and biliary tract. Being adsorbed from the intestine, metamizole sodium does not selectively inhibit the work of cyclooxygenase enzymes and reduces the production of prostaglandin from arachidonic acid, thereby achieving an analgesic result, increasing resistance to pain.

Papaverine hydrochloride activates the accumulation of cyclic AMP and reduces the amount of calcium in the cells, thereby eliminating spasms and pain in the abdominal organs.

Bendazole (Dibazol) has a hypotensive, vasodilating effect, activates and maintains the vital activity of the spinal cord. Presented as part of the drug, phenobarbital has a pronounced sedative effect, activates the work of other ingredients of the drug.

The pharmacological effect is achieved due to the multicomponent structure of the drug. The medicine calms, eliminates spasm and lowers the temperature, anesthetizes, dilates blood vessels and improves blood circulation.

The synergy of papaverine, bendazole and analgin allows the use of the drug to desensitize pain in migraines and acute headaches of a different origin.

Composition and form of release

Andipal is produced in tablet form. Tablets for oral use have one dosage of active ingredients. the role of the active elements is played by bendazol, analgin, phenobarbital, papaverine. Talc, starch and stearic acid are used as excipients.

Round flat-cylindrical white or yellow pills are generally available for purchase in contoured plastic blisters or paper plates. Packed in cardboard boxes of 10, 30, 100 units.

Indications for use

The effectiveness of Andipal as an antispasmodic and medical device for symptomatic therapy of contraction of cerebral vessels and vessels that ensure the movement of blood from the periphery. The use of the drug promotes vasodilation and, accordingly, improves hemodynamics, normalizes blood pressure.

Among the indications for the use of the drug are such diseases and pathological conditions:

mild stage of hypertension;
headaches caused by migraine;
pain syndrome accompanying cerebral spasms of the brain.

The drug is widely used to eliminate spastic pain, has a relaxing effect on the smooth muscles of the abdominal organs.

The effectiveness of the use of drugs to equalize pressure with systemic treatment of mild forms of idiopathic hypertension. Patients with initial stages arterial hypertension Andipal is prescribed to lower blood pressure.

Side effects

Andipal may provoke unwanted adverse reactions. They do not occur in all patients, their intensity when they appear in each patient may vary depending on the individual characteristics of human health.

The gastrointestinal tract may respond to the use of the drug with constipation, nausea.

Due to the presence of phenobarbital in the composition, the drug can provoke the development of a condition bordering on depression. Especially this risk increases in patients of older and advanced age.

Individual hypersensitivity to any of the ingredients of the drug causes allergic reactions.

A long period of use can lead to a deterioration in blood composition due to the inhibitory effect of analgin.

Contraindications

Among the prohibitions to prescribe the drug is the presence of hypersensitivity to active ingredients or excipients. It is forbidden to prescribe and use Andipal during the first three months of pregnancy and during lactation; very carefully it can be prescribed to women carrying a child in the second and third trimester. A direct contraindication to the use of the drug is the age of pediatric patients under 8 years of age.

autoimmune disease - asthenic bulbar paralysis;
porphyria;
hemolytic anemia associated with deficiency of glucose-6-phosphate hydrogenase;
dysfunction of the hematopoietic system;
severe and terminal degree of renal failure;
decompensated and dystrophic stages of liver failure;
instability of the heart rhythm;
intestinal obstruction.

Method and features of application

The instruction recommends taking the tablets by mouth. The standard dose is prescribed in the amount of 1 pill, taken 2-3 times a day. The duration of the treatment period with the use of the drug Andipal cannot exceed 10 days.

The attending physician prescribes an individual dose for each patient, therapy should be under his control and supervision. If the drug does not have the desired therapeutic effect, you should definitely consult a doctor to correct the chosen treatment strategy.

The drug affects the ability to drive Vehicle or the ability to operate potentially dangerous machinery. Before studying the influence of Andipal on your body, you should not drive and get to work, which is performed with increased concentration and attention.

Andipal reduces the level of blood pressure, so it is prohibited for use in patients with hypotension, due to the risk of developing pathological transformations in the brain.

The components that are combined in the drug can adversely affect the state of the blood, so it is necessary to control the composition of the blood during prolonged treatment.

Application during pregnancy

Andipal has a direct contraindication to the appointment of women in the first trimester of pregnancy. Due to the presence of phenobarbital in the composition, it negatively affects the work and development of the baby's brain.

Prolonged use inhibits the development of the fetus. The possibility of the birth of a child with a congenital diagnosis of cerebral palsy is increasing. In the second and third trimester of gestation, the drug is allowed to be taken provided that the possible benefit to the mother outweighs the hypothetical risks to the fetus. Under this condition, therapy is carried out under the supervision of a physician.

Taking the medicine is strictly prohibited during breastfeeding. breast milk. In a situation of urgent need to use the drug, lactation is interrupted for the period of treatment.

Alcohol compatibility

Andipal, which dilates blood vessels, several times enhances the effect of alcohol on the body. The instruction strictly prohibits the use of the drug, both before and after taking alcoholic beverages. Non-compliance with prescriptions can cause exaggerated unpredictable side effects.

Interaction with other drugs

Joint treatment with the use of diuretics (lasix, furosemide), beta-blockers (anaprilin), myotropic antispasmodics (eufillin), calcium channel blockers (nifedipine) and nitrates (nitroglycerin) increases the hypotensive effect of Andipal.

The opposite effect is observed when the drug is used together with H- and M-cholinomimetics (nicotine, acetylcholine), andreno-mimetics (adrenaline, ephedrine), analeptics (camphor, cytisine, sulfocamphocaine).

Opium analgesics, when combined with the drug, increase the likelihood of creating conditions for the development of side effects of the drug.

Sorbents reduce the absorption of the drug in the intestine.

Overdose

It is forbidden to independently change the amount of the necessary medicine per day, exceeding the prescribed portion can provoke an overdose.

Drug poisoning is accompanied by headache, drowsiness, malfunctions gastrointestinal tract- nausea, vomiting, abdominal pain. When the first signs of an overdose appear, it is urgent to do a gastric lavage, drink sorbents, and consult a doctor.

Analogues

An analogue identical in structure to the drug has not been created. According to the similarity of indications, Analgin-Dibazol-Papaverine, Kofalgin drugs can be an alternative.

Terms of sale

Pharmacy chains are sold without a doctor's prescription.

Storage conditions

Store the medicine in a place closed from the sun, subject to a temperature regime not higher than 25 degrees Celsius. Tablets should be out of the reach of children and pets.

Composition

One pill contains 0.25 metamizole sodium (analgin), 0.2 bendazol, 0.2 papaverine hydrochloride, 0.2 mg phenobarbital.

Excipients in the form of talc, potato starch, stearic acid, calcium stearate are part of the pills.

Instruction

FROMleaving

active substance: 1 tablet contains metamizole sodium - 0.25 g, bendazole hydrochloride - 0.02 g, papaverine hydrochloride - 0.02 g;

Excipients: potato starch, calcium stearate, talc.

Pharmacotherapeutic group

Analgesic and antispasmodic.

Pharmacological properties . Combined drug with analgesic, antispasmodic and vasodilating effects due to the specific action of its components. The drug also exhibits a weak antihypertensive and antipyretic effect.

Metamizole sodium- a non-steroidal anti-inflammatory drug (NSAID) of the group of pyrazolone derivatives, has anti-inflammatory, analgesic and antipyretic effects, the mechanism of action of which is due to inhibition of COX and blocking the synthesis of prostaglandins from arachidonic acid, as well as a violation of the conduction of pain extra- and proprioceptive impulses, an increase in the excitability threshold of thalamic pain centers sensitivity, increased heat transfer.

Bendazole hydrochloride has an antispasmodic, hypotensive effect, and also has a stimulating effect on the functions of the spinal cord, helps to restore functions peripheral nerves, has a moderate immunostimulating effect.

papaverine hydrochloride has a myotropic, antispasmodic, hypotensive effect. It blocks phosphodiesterase, promotes the accumulation of cAMP and a decrease in the calcium content in the cell, relaxes the smooth muscles of blood vessels and internal organs.

When taken orally, it is rapidly and completely absorbed. In the walls of the intestine, it is hydrolyzed to form an active metabolite. The action develops in 20-40 minutes and reaches a maximum after 2 hours. It is metabolized in the liver. Excreted by the kidneys.

Indications

Pain syndrome associated with spasm of blood vessels, smooth muscles.

Contraindications

Hypersensitivity to the components of the drug. Arterial hypotension, atrioventricular conduction disorders, increased muscle tone, convulsive syndrome. Blood diseases - agranulocytosis, thrombocytopenia, neutropenia, hepatoporphyria, eosinophelia, increased blood transaminase levels, severe liver and kidney dysfunction, coma, respiratory depression, broncho-obstructive syndrome, hemolytic anemia, pregnancy, breastfeeding, childhood, etc.

18 years old, over 60 years old, AV block, glaucoma, glucose-6-phosphate dehydrogenase deficiency.

Dosage and administration

Apply inside 1-2 tablets 2-3 times a day. The maximum daily dose is 4 tablets. The course of treatment is no more than 1-3 days. Tablets are taken after meals with a small amount of water.

If there is no effect from the treatment, you should consult a doctor!

Application Precautions

Before starting treatment, consult your doctor! Do not use the drug for longer than the prescribed period without the recommendation of a doctor! If the signs of the disease do not begin to disappear, or, on the contrary, the state of health has worsened, or undesirable effects have appeared, consult a doctor for advice on further use of the drug!

Precautionary measures

Before starting treatment, consult your doctor!

papaverine and dibazol :

With caution, short courses should be prescribed and preferably used in the treatment of people over 60 years of age, due to the possibility of reducing their cardiac output and worsening electrocardiogram (ECG) parameters,

Only small doses of the drug should be used in people with traumatic brain injury, impaired liver and kidney function, hypothyroidism, adrenal insufficiency, since they have an increased hypotensive effect of the drug. In individuals with benign prostatic hyperplasia, high doses of the drug can provoke the development of acute urinary retention.

Use with caution in renal and / or hepatic insufficiency; diseases of the bronchi, accompanied by excessive accumulation of secretions; a history of gastrointestinal bleeding.

Metamizole sodium :

special instructions

When using the drug, agranulocytosis may develop, and therefore, if an unmotivated fever, chills, sore throat, difficulty swallowing, stomatitis, as well as inflammation of the external genital organs and anus is detected, immediate withdrawal of the drug is necessary.

The risk of potentially severe anaphylactoid reactions to metamizole sodium is significantly increased in patients with:

Asthma syndrome or angioedema on non-narcotic analgesics;

Bronchial asthma with concomitant rhinosinusitis and nasal polyps, chronic urticaria;

Intolerance to dyes (tartrazine) and preservatives (benzoates);

Alcohol intolerance.

When administered to patients with acute cardiovascular pathology careful monitoring of hemodynamics is necessary due to the hypotensive effect. Use with caution in patients with blood pressure (BP) below 100 mm Hg, with myocardial infarction, multiple trauma, with anamnestic indications of liver and kidney diseases (pyelonephritis, glumerulonephritis), in the treatment of cytostatics, blood diseases. The risk of such reactions is also increased in patients with dehydration or dehydration, unstable blood pressure or incipient circulatory failure (eg, in patients with multiple injuries or heart attack), in patients with high temperature.

In such patients, careful examination and careful monitoring is required. Presumptive measures (such as circulatory stabilization) may be necessary to reduce the risk of hypotensive reactions.

In exceptional cases, the drug can be used in patients in whom lowering blood pressure is unacceptable, for example, in severe coronary disease heart or corresponding stenosis of the cerebral arteries. In such cases, the use of the drug is possible only after careful monitoring of hemodynamic parameters.

In patients with renal or hepatic insufficiency, metamizole sodium should be taken only after a careful assessment of the benefits, risks and necessary precautions.

Children. Contraindicated.

Use during pregnancy or lactation I breastfeed

Interaction with drugs

If you are taking any other medicines, be sure to consult your doctor about the further use of Andipal.

With the simultaneous use of the drug with antispasmodics, sedatives, diuretics, the hypotensive effect is enhanced. The drug reduces the effect of dopegyt, increases the hypoglycemic activity of oral antidiabetic drugs, enhances the effect of ethanol, indirect anticoagulants, glucocorticosteroids (GCS) and indomethacin. With simultaneous use with cyclosporine, the concentration of the latter in the blood decreases. The effectiveness of Andipal is reduced by phenylbutazone, barbiturates and other inducers of microsomal liver enzymes; simultaneous appointment with other non-narcotic analgesics, tricyclic antidepressants, hormonal contraceptives and allopurinol leads to an increase in the toxic effect of andipal. Sedatives and tranquilizers enhance the analgesic effect of Andipal. Thiamazole and sarcolysin increase the risk of developing hematopoietic disorders. The effect of andipal is enhanced by codeine, H2 receptor blockers and propranolol. Simultaneous use with chlorpromazine or other phenothiazine derivatives can lead to the development of severe hypothermia; caution is necessary with the simultaneous use of the drug with radiopaque substances, colloidal blood substitutes and penicillin, procainamide, reserpine, quinidine, salicylates; it is possible to reduce the hypotensive effect of methyldopa and the antiparkinsonian effect of levodopa.

Side effects

From the gastrointestinal tract: nausea, constipation.

From the side of the central nervous system: drowsiness, increased sweating.

From the side of the cardiovascular system: violation of the heart rhythm, a decrease in cardiac output, as a result of which deterioration in the electrocardiogram is possible.

Allergic reactions: skin rash, itching, urticaria, angioedema.

Metamizole sodium :

Allergic reactions. Uncommon: rash; rarely: maculopapular exanthema, anaphylactic or anaphylactoid reactions. They occur mainly within the first hour after ingestion. Usually manifested in the form of skin reactions, such as itching, burning, redness, rash, swelling, rarely - shortness of breath. May occur with more severe forms, such as: urticaria, severe Quincke's edema (including the larynx), severe bronchospasm, heart rhythm disturbance, arterial hypotension (sometimes preceded by an increase in blood pressure); very rare: analgesic-induced bronchial asthma(including in patients with aspirin asthma), Stevens-Johnson syndrome or Lyell's syndrome, shock.

Reception of metamizole sodium with the appearance of skin reactions should be immediately discontinued.

Blood and lymphatic system. Rare: leukopenia, agranulocytosis or thrombocytopenia. These reactions are probably immunological. They can occur even if metamizole sodium has previously been used without complications. The risk of developing agranulocytosis may be increased if metamizole sodium is taken for more than 1 week.

Agranulocytosis is manifested by high fever, chills, sore throat, difficulty swallowing, inflammation of the mouth, nose, throat, and genitals, or anal itching. The erythrocyte sedimentation rate (ESR) is significantly accelerated, the number of granulocytes is significantly reduced or completely absent. As a rule, but not always, the values of hemoglobin, erythrocytes and platelets remain within the normal range.

Reception of metamizole sodium should be stopped immediately, even in the absence of the results of laboratory diagnostic tests, subject to a sudden deterioration in the general condition of the patient.

The cardiovascular system. Infrequently: hypotensive reactions during or after the use of the drug. Even with hyperthermia, a decrease in blood pressure can occur without any signs of a hypersensitivity reaction.

Diseases of the kidneys and urinary tract. Very rarely: acute deterioration of renal function, after which proteinuria, oligo- or anuria and acute renal failure, acute interstitial nephritis may develop. Red staining of urine.

If side effects or other unusual reactions occur, consult your doctor about further use of the drug.

Overdose

Metamizole poisoning symptoms: hypothermia, palpitations, shortness of breath, tinnitus, nausea, vomiting, weakness, drowsiness, impaired consciousness, convulsive syndrome; development of acute agrunolocytosis, acute renal and hepatic insufficiency is possible. Symptoms of papaverine poisoning: diplopia, weakness, drowsiness, lethargy. Symptoms of bendazol poisoning: arterial hypotension, headache, weakness.

Treatment: drug withdrawal, gastric lavage, administration of activated charcoal, symptomatic therapy aimed at maintaining vital functions. The main metabolite of metamizole - 4 N-methyl-amino-antipyrine - can be removed by hemodialysis. The treatment of intoxication, as well as the prevention of serious complications, require intensive medical supervision and treatment.

If symptoms of an overdose appear, you should immediately seek medical help!

2 years. Do not use the drug after the expiration date indicated on the package.

Holiday Rules

Without recipe.

Name and address of the manufacturer of the medicinal product.

PJSC "Monfarm" 19100. Ukraine, Cherkasy region, Monastyrishche, st. Factory.