Description of the drug Cefalexin - composition and instructions for use, contraindications and analogues. Injections, tablets and suspension of cephalexin, instructions for use and analogues From which cephalexin tablets in capsules

Cefalexin INN

Description of the active substance (INN) Cephalexin.

Pharmacology : pharmachologic effect - antibacterial . Inhibits transpeptidase - an enzyme involved in the biosynthesis of the mucopeptide of the bacterial cell wall, has a bactericidal effect. Stable in an acidic environment.

Active against gram-positive (staphylococci, including those producing penicillinase, streptococci, pneumococci, diphtheria bacillus) and, to a lesser extent, gram-negative microorganisms (meningococci, gonococci, E. coli, salmonella, shigella, neisseria, certain types Proteus, influenza bacillus, Klebsiella, pathogenic spirochetes and indole-positive strains of Proteus, anaerobes). Resistant to penicillinase of staphylococci, but destroyed by cephalosporinase of gram-negative microorganisms.

Indications : Infections (mild and medium degree severity) ENT organs (otitis media, tonsillitis, sinusitis), upper and lower respiratory tract(pharyngitis, pneumonia, bronchopneumonia, pleural empyema, lung abscess), genitourinary system (acute and chronic pyelonephritis, cystitis, urethritis, prostatitis, epididymitis, gynecological infections, gonorrhea), skin and soft tissues (furunculosis, abscess, cellulitis, pyoderma, lymphangitis ), bones and joints (acute and chronic osteomyelitis).

Contraindications : Hypersensitivity (including to other beta-lactamines - penicillins, cephalosporins, carbapenems).

Use during pregnancy and lactation : Perhaps if the expected effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Side effects : Nausea, vomiting, diarrhea, dry mouth, lack of appetite, abdominal pain, transient increase in serum aminotransferases and alkaline phosphatase, pseudomembranous colitis, cholestatic jaundice, hepatitis, headaches, dizziness, weakness; leukopenia, neutropenia, thrombocytopenia, dysbacteriosis, superinfection, allergic reactions: itching, skin rash, urticaria, angioedema, anaphylactic shock.

Interaction : Furosemide, ethacrynic acid, and nephrotoxic antibiotics increase the risk of kidney damage. Enhances the effect of indirect anticoagulants. Salicylates and indomethacin slow down excretion.

Dosage and administration : Inside (before meals). Adults: 250-500 mg 2-4 times a day. The daily dose is 1-2 g, if necessary, can be increased to 4 g.

Children weighing less than 40 kg - 25-50 mg / kg per day (up to 100 mg / kg per day).

In case of violation of the excretory function of the kidneys with Cl creatinine up to 5-20 ml / min, the maximum daily dose should not exceed 1.5 g, and with Cl creatinine less than 5 ml / min - 0.5 g. daily dose divided into 4 doses. The duration of treatment is 7-14 days.

Cephalexin is medicine from the group of cephalosporin antibiotics of the first generation. The drug has an antimicrobial effect.

Cephalexin for cystitis

Cefalexin regimen for cystitis: 250 mg - 500 mg 30 minutes - 1 hour before meals every 6 - 12 hours (2 - 4 times a day) depending on the severity of the infection. Course of treatment: 1 - 2 weeks (at least). The dosage for children is 25 mg - 50 mg per 1 kg of body weight.

How many days to drink Cefalexin and the dose of the drug is determined solely by the doctor individually in each case.

Release form Cefalexin

Dosage form of Cefalexin: capsules, suspension for parenteral administration.

How to use Cefalexin: inside, intramuscularly, intravenously.

Manufacturer Cefalexin: Pharmtekhnologiya, Belarus; New Ton, Moldova; Natur Product, Netherlands; Europharmaco, Moldova.

Composition of Cefalexin

1 capsule of Cefalexin contains 250 mg or 500 mg of the active substance.

1 ampoule of Cefalexin (5 ml suspension) contains 125 or 250 mg of the active substance.

Description of Cefalexin

The medicine has a bactericidal effect. Its properties are due to the ability of Cefalexin to disrupt the synthesis of the cell wall of pathogenic microorganisms.

The drug is active against Escherichia, Shigella, Staphylococcus, Streptococcus, Spirochete, Neisseria, Klebsiella and a number of other microbes.

The possibility of using Cefalexin in urological practice, in particular for the treatment of inflammation Bladder, due to the excretion of the active substance in the urine in unchanged form.

Indications for the use of Cefalexin

The appointment of Cefalexin to men and women is indicated for the following diseases and conditions:

• Infections of the urinary system:

1. Cystitis (acute, exacerbation of chronic);
2. Urethritis;
3. Pyelonephritis;
4. Prostatitis;

• ENT infections;
• respiratory infections;
• Infections of the bone, soft tissues, skin;
• Gonorrhea.

Cefalexin contraindications

The use of Cefalexin is contraindicated in case of hypersensitivity to cephalosporin antibiotics.

Side effects of Cefalexin

Side effects of Cephalexin treatment include:

• From the digestive tract and liver: diarrhea (loose stools), transient (temporary) increase in the activity of hepatic transaminases (enzymes);
• From the hematopoietic system: eosinophilia (increase in the number of eosinophils in the blood), neutropenia (decrease in the number of neutrophils in the blood);
• From the nervous system (CNS): headache, dizziness, weakness, fatigue;
• Allergy (rare): from skin manifestations (urticaria and itching) to anaphylactic shock;
• Candidiasis, dysbacteriosis (with prolonged use).

Overdose of Cefalexin

An overdose of Cefalexin is accompanied by vomiting, pain in the upper abdomen, liquid stool possible blood in the urine.

Treatment is symptomatic (should include Activated carbon).

Instructions for use Cefalexin

Cefalexin is prescribed at a dosage of 0.25 - 0.5 g every 6 - 12 hours.

Min. daily dose: 1 g.

Max. daily dose: 4 g.

Dosage for children: 25-50 mg per 1 kg of body weight.

Multiplicity of reception: four times a day.

The duration of the course of therapy: 7 - 14 days.

How to take: half an hour before meals with drinking water.

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Structural formula

Russian name

Latin name of the substance Cephalexin

Cefalexinum ( genus. Cefalexini)

chemical name

]-7-[(Aminophenylacetyl)amino]-3-methyl-8-oxo-5-thia-1-azabicyclooct-2-ene-carboxylic acid (as monohydrate)

Gross formula

C 16 H 17 N 3 O 4 S

Pharmacological group of the substance Cefalexin

Nosological classification (ICD-10)

CAS code

15686-71-2

Characteristics of the substance Cefalexin

An antibiotic of the 1st generation cephalosporin group.

White or white with a slightly yellowish tint powder with a characteristic odor. It is difficult and slowly soluble in water, practically insoluble in alcohol.

Pharmacology

pharmachologic effect- antibacterial, bactericidal.

It inhibits transpeptidase, an enzyme involved in the biosynthesis of the mucopeptide of the bacterial cell wall. Stable in an acidic environment.

Active against gram-positive microorganisms - Staphylococcus spp.(not producing and producing penicillinase), Staphylococcus epidermidis(penicillin-resistant strains), Streptococcus spp.(incl. Streptococcus pneumoniae And Streptococcus pyogenes), Corynebacterium diphtheriae, Clostridium spp., and, to a lesser extent, gram-negative microorganisms - Neisseria meningitidis, Neisseria gonorrhoeae, Shigella spp., Salmonella spp., E. coli Moraxella catarrhalis, Klebsiella pneumoniae, Treponema spp. Resistant to penicillinase of staphylococci, but destroyed by cephalosporinase of gram-negative microorganisms.

Ineffective against Pseudomonas spp., including Pseudomonas aeruginosa, Proteus mirabilis(indole positive strains), mycobacterium tuberculosis, anaerobes.

After oral administration, it is almost completely absorbed from the gastrointestinal tract. Eating slows down absorption without affecting its completeness. Bioavailability - 95%. T max - 1-2 hours. In patients with normal function kidneys, the therapeutic concentration in the blood persists for 4-6 hours. About 15% binds to plasma proteins. It is evenly distributed in the body, high concentrations are observed in all organs and tissues, especially in the liver and kidneys, lungs, bronchial mucosa, heart, and also in bile, gallbladder, bones and joints, respiratory tract. It crosses the placenta and is found in small amounts in breast milk. It diffuses poorly through the unchanged BBB. It is excreted mainly by the kidneys (by glomerular filtration and tubular secretion) unchanged (70-89%), in a small amount - with bile. Usually 80-100% of an oral dose is excreted in the urine during the first 6 hours.

The use of the substance Cefalexin

Infectious diseases (mild and moderate severity) caused by susceptible microorganisms: infections of the ENT organs (incl. otitis media, pharyngitis, tonsillitis, sinusitis), upper and lower respiratory tract (pneumonia, bronchitis, bronchopneumonia, pleural empyema, lung abscess), urinary tract(including acute and chronic pyelonephritis, cystitis, urethritis), gynecological infections (including endometritis, vulvovaginitis), skin and soft tissues (furunculosis, abscess, phlegmon, pyoderma), bones and joints (including including acute and chronic osteomyelitis), prostatitis, epididymitis, gonorrhea, lymphangitis.

Contraindications

Hypersensitivity, incl. to other cephalosporins.

Application restrictions

Renal failure, pseudomembranous colitis (history), infancy (up to 6 months).

Use during pregnancy and lactation

During pregnancy, it is possible if the expected effect of therapy outweighs the potential risk to the fetus.

At the time of treatment should stop breastfeeding.

Side effects of the substance Cephalexin

From the nervous system and sensory organs: headache, dizziness, weakness, drowsiness, agitation, hallucinations, convulsions.

From the side of cardio-vascular system and blood (hematopoiesis, hemostasis): reversible leukopenia, neutropenia, thrombocytopenia, PT prolongation, eosinophilia.

From the digestive tract: nausea, vomiting, diarrhea, dry mouth, loss of appetite, abdominal pain, transient increase in serum aminotransferases and alkaline phosphatase, pseudomembranous colitis, cholestatic jaundice, hepatitis, dysbacteriosis.

From the genitourinary system: vaginitis, vaginal discharge, interstitial nephritis, itching of the genitals and anus.

Allergic reactions: itching, skin rash, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), urticaria, angioedema, anaphylactic shock, arthralgia.

Others: candidiasis, incl. intestinal candidiasis, oral cavity, genital candidiasis; superinfection.

Interaction

Furosemide, ethacrynic acid and nephrotoxic antibiotics (including aminoglycosides) increase the risk of kidney damage. Cefalexin enhances the effect of indirect anticoagulants. Salicylates and indomethacin slow down the excretion of cephalexin.

Overdose

Symptoms: Nausea, vomiting, epigastric pain, diarrhea, hematuria.

Treatment: activated charcoal (more effective than lavage), maintaining airway patency, monitoring vital signs, blood gases and electrolyte balance.

Routes of administration

Inside, in / m, in / in.

Precautions Substance Cephalexin

In patients with impaired renal function, cumulation is possible (correction of the dosing regimen is required). Use with caution in the presence of a history of allergic reactions to penicillin antibiotics, carbapenems.

There may be a false positive reaction for sugar in the urine and a positive reaction in the Coombs test. In staphylococcal infections, there is cross-resistance between cephalosporins and isoxazolylpenicillins.

Antibacterial, bactericidal medicine is Cefalexin. Instructions for use prescribes taking capsules and tablets of 250 mg and 500 mg, granules or powder for the preparation of a suspension or syrup for infectious pathologies (pneumonia, bronchitis, tonsillitis).

Release form and composition

Cefalexin is produced in the following dosage forms:

1. Film-coated tablets 250 mg.
2. Capsules 250 mg and 500 mg.
3. Powder for suspension for oral administration 125 mg, 250 mg and 500 mg. A suspension is sometimes erroneously called a syrup.
4. Granules for oral suspension 250 mg.

Capsules or tablets are packed in blisters of 8 pieces (2) in a cardboard box with detailed instructions attached.

Each capsule contains the active ingredient Cefalexin - 250 mg or 500 mg

In 5 ml suspension of cephalexin 250 mg. Sodium saccharinate, citric acid, iron oxide, guar gum, sodium benzoate, simethicone, sucrose, flavor - as excipients.

Indications for use

What helps Cefalexin? Tablets and suspension are prescribed:

• osteomyelitis;
• endometritis;
• gonorrhea;
• infection of the genitourinary system (cystitis, pyelonephritis, urethritis, endometritis, prostatitis, gonorrhea, vulvovaginitis);
• purulent diseases of the skin and tissues (phlegmon, furunculosis, pyoderma, abscess, lymphadenitis);
• diseases of ENT organs (sinusitis, pharyngitis, otitis media, tonsillitis);
• respiratory infections (pneumonia, lung abscess, bronchopneumonia, empyema).

Instructions for use

Cephalexin tablets, capsules and granules

Inside, 30-60 minutes before meals, drinking water. The average dose for adults and children over 10 years old is 250-500 mg every 6 hours. The daily dose of the drug should be at least 1-2 g, if necessary, can be increased to 4 g. The duration of the course of treatment is 7-14 days.

In infections caused by group A beta-hemolytic streptococcus, the minimum duration of treatment is 10 days.

• With otitis media - a dose of 75 mg / kg /, the frequency of administration - 4 times a day.
• With streptococcal pharyngitis, infections of the skin and soft tissues, the frequency of administration is 2 times a day.
• In severe infections, the daily dose can be increased to 100 mg/kg of body weight, and the frequency of administration - up to 6 times a day.

Suspension preparation: add water to the vial to the risks and shake well. The prepared suspension is stable at room temperature for 14 days. Before each use, the suspension must be shaken. 5 ml of the finished suspension contains 250 mg of cephalexin.

Powder for suspension preparation

When prescribing the drug, children are recommended to be guided by the following scheme:

• up to 1 year (body weight up to 10 kg) - 0.5 g;
• from 1 to 6 years - 0.5-1 g;
• from 6 to 10 years - 1 g;
• from 10 years to 14 years - 1-2 years.

Suspension preparation rules

To prepare a suspension in a vial containing 2.5 g of the drug, add 80 ml of distilled water. 1 ml of the finished suspension contains 25 mg of cephalexin. The suspension is dosed with a special spoon having two marks: the lower one corresponds to 2.5 ml (62.5 mg) and the upper one - 5 ml (125 mg). Shake the vial before using the suspension.

See also: how to take an antibiotic -.

pharmachologic effect

Cephalexin is a 1st generation cephalosporin antibiotic. The drug disrupts the synthesis of the cell wall, resistant to lactamases.

The drug is active against gram-positive microorganisms - Staphylococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes), Corynebacterium diphtheriae; gram-negative microorganisms - Neisseria meningitidis, Neisseria gonorrhoeae, Shigella spp., Salmonella spp., Escherichia coli, Klebsiella spp. (including Klebsiella pneumoniae), Moraxella catarrhalis, Proteus mirabilis; Treponema spp., radiant fungi.

The drug is ineffective against Pseudomonas aeruginosa, Proteus spp. (indole-positive strains), Morganella morganii, Mycobacterium tuberculosis, Enterococcus faecalis, Haemophilus spp., Enterobacter spp., Serratia spp., Pseudomonas spp., Aeromonas spp., Acinetobacter spp., methicillin-resistant strains, anaerobic microorganisms.

Cephalexin is resistant to staphylococcal penicillinase, but is destroyed by cephalosporinase of gram-negative microorganisms.

Contraindications

Before starting therapy with Cefalexin, the patient must be tested to identify the causative agent of the infection and carefully study the attached instructions. Cefalexin capsules should not be taken orally if one or more of the following conditions are present:

• cases of severe allergic reactions to cephalosporins;
• severe renal failure;
• age of patients up to 12 years (for this dosage form);
• pregnancy and period breastfeeding;
• severe liver disease, accompanied by impaired organ function;
• individual intolerance to the drug.

Relative contraindications are the presence of chronic diseases organs of the gastrointestinal tract and pseudomembranous colitis, including a history.

Side effects

According to some reviews of Cefalexin, the following side effects can be noted when using an antibiotic:

• From the digestive system: vomiting, nausea, dry mouth, diarrhea, loss of appetite, abdominal pain, intestinal candidiasis, dyspepsia, in some cases - pseudomembranous enterocolitis, hepatitis, cholestatic jaundice.
• On the part of laboratory parameters: an increase in prothrombin time, an increase in the activity of alkaline phosphatase and hepatic transaminases.
• From the hemopoietic system: neutropenia, reversible leukopenia, thrombocytopenia.
• From the reproductive system: vaginal discharge, vaginitis, genital candidiasis.
• From the urinary system, interstitial nephritis is possible.
• From the side of the central nervous system: agitation, weakness, hallucinations, headache, drowsiness, dizziness, convulsions.

In addition, reviews of Cefalexin include the possibility of allergic reactions, urticaria, malignant exudative erythema, anaphylaxis, toxic epidermal necrolysis, arthritis, genital itching, dermatitis, in rare cases- Quincke's edema.

Children, during pregnancy and lactation

The use of the drug during pregnancy and lactation is possible only if the intended benefit to the mother outweighs the potential risk to the fetus. If necessary, the appointment of the drug during lactation should stop breastfeeding.

Use in children

The use of capsules in children under the age of 3 is contraindicated. For children under the age of 10 years, the drug is recommended to be prescribed in the form of a suspension for oral administration.

special instructions

Patients with a history of allergic reactions to penicillins and carbapenems may have hypersensitivity to cephalosporin antibiotics. During the treatment period, a positive direct Coombs reaction is possible, as well as a false-positive urine test for glucose.

The drug can not be combined with the use of ethanol. In case of impaired renal function, accumulation of cephalexin in the body is possible. Dose adjustment required. In staphylococcal infections, there is cross-resistance between cephalosporins and isoxazolylpenicillins.

drug interaction

Cefalexin enhances the effect of indirect anticoagulants. The risk of kidney damage increases when used with phenylbutazone, aminoglycosides, ethacrynic acid, polymyxins.

When used with a dose adjustment is necessary. Salicylates and Indomethacin slow down the excretion of the active substance.

Cefalexin's analogs

According to the structure, analogues are determined:

1. Ospeksin.
2. Soleksin Forte.
3. Piassan.
4. Ecocephron.
5. Cefaklen.
6. Cephalexin AKOS.
7. Felexin.
8. Zeff.
9. Soleksin.
10. Palettex.
11. Keflex.

Holiday conditions and price

The average cost (tablets 500 mg No. 16) in Moscow is 87 rubles. Released by prescription.

Store in a dry, dark place, out of the reach of children, at a temperature of +15...+25 C. Shelf life - 2 years. The prepared aqueous suspension should be stored at a temperature of +15…+25 C for no more than 6 days, in the refrigerator - no more than 14 days.

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Cephalexin is a drug from the group of cephalosporin antibiotics of the first generation. The drug has an antimicrobial effect.

Cephalexin for cystitis

Cefalexin regimen for cystitis: 250 mg - 500 mg 30 minutes - 1 hour before meals every 6 - 12 hours (2 - 4 times a day) depending on the severity of the infection. Course of treatment: 1 - 2 weeks (at least). The dosage for children is 25 mg - 50 mg per 1 kg of body weight.

How many days to drink Cefalexin and the dose of the drug is determined solely by the doctor individually in each case.

Release form Cefalexin

Dosage form of Cefalexin: capsules, suspension for parenteral administration.

How to use Cefalexin: inside, intramuscularly, intravenously.

Manufacturer Cefalexin: Pharmtekhnologiya, Belarus; New Ton, Moldova; Natur Product, Netherlands; Europharmaco, Moldova.

Composition of Cefalexin

1 capsule of Cefalexin contains 250 mg or 500 mg of the active substance.

1 ampoule of Cefalexin (5 ml suspension) contains 125 or 250 mg of the active substance.

Description of Cefalexin

The medicine has a bactericidal effect. Its properties are due to the ability of Cefalexin to disrupt the synthesis of the cell wall of pathogenic microorganisms.

The drug is active against Escherichia, Shigella, Staphylococcus, Streptococcus, Spirochete, Neisseria, Klebsiella and a number of other microbes.

The possibility of using Cefalexin in urological practice, in particular for the treatment of inflammation of the bladder, is explained by the excretion of the active substance in the urine in unchanged form.

The appointment of Cefalexin to men and women is indicated for the following diseases and conditions:

• Infections of the urinary system:

1. Cystitis (acute, exacerbation of chronic);
2. Urethritis;
3. Pyelonephritis;
4. Prostatitis;

• ENT infections;
• respiratory infections;
• Infections of the bone, soft tissues, skin;
• Gonorrhea.

Cefalexin contraindications

The use of Cefalexin is contraindicated in case of hypersensitivity to cephalosporin antibiotics.

Side effects of Cefalexin

Side effects of Cephalexin treatment include:

• From the digestive tract and liver: diarrhea (loose stools), transient (temporary) increase in the activity of hepatic transaminases (enzymes);
• From the hematopoietic system: eosinophilia (increase in the number of eosinophils in the blood), neutropenia (decrease in the number of neutrophils in the blood);
• From the nervous system (CNS): headache, dizziness, weakness, fatigue;
• Allergy (rare): from skin manifestations (urticaria and itching) to anaphylactic shock;
• Candidiasis, dysbacteriosis (with prolonged use).

Overdose of Cefalexin

An overdose of Cefalexin is accompanied by vomiting, pain in the upper abdomen, loose stools, blood in the urine is possible.

Treatment is symptomatic (should include activated charcoal).

Instructions for use Cefalexin

Cefalexin is prescribed at a dosage of 0.25 - 0.5 g every 6 - 12 hours.

Min. daily dose: 1 g.

Max. daily dose: 4 g.

Dosage for children: 25-50 mg per 1 kg of body weight.

Multiplicity of reception: four times a day.

The duration of the course of therapy: 7 - 14 days.

How to take: half an hour before meals with drinking water.

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Cefalexin instructions for use, composition, indications, analogues and reviews

Read the official information about the drug Cefalexin, the instructions for use of which include general information and treatment regimen. The text is provided for informational purposes only and is not a substitute for medical advice.

Cefalexin is a first-generation antibiotic. Works only on bacterial diseases. Cefalexin fights well against such bacteria as: Staphylococcus, Streptococcus, Corynebacterium diphtheriae, Salmonella spp, Escherichia coli, Klebsiella spp. , Moraxella catarrhalis, Proteus mirabilis, Treponema spp, radiant mushrooms.

Composition and form of release

Release form of the drug:

The composition of the drug in the form of capsules

• Active ingredient: 250 mg of cephalexin in each capsule.
• Excipients: potato starch, starch 1500, povidone, methylcellulose, stearic acid.
• Capsule composition: gelatin, titanium dioxide E 171, quinoline yellow E 104, sunset yellow E 110.

Cefalexin - instructions for use in various dosage forms

The drug will not have any effect on: Pseudomonas aeruginosa, Proteus spp, Morganella morganii, Mycobacterium tuberculosis, Enterococcus faecalis, Haemophilus spp, Enterobacter spp, Serratia spp, Pseudomonas spp, Aeromonas spp, Acinobacter spp, anaerobic microorganisms.

The use of Cefalexin should be prescribed only by a person competent in this matter, that is, a doctor. The dosage is prescribed individually, as it depends on what disease the patient has, the severity of its course and where the infection is located.

If adults get sick with an infection in which microorganisms are hypersensitive to Cephalexin, then their daily dose should not exceed 2 grams. If the microorganisms of the infection are less sensitive to Cefalexin, then the dose of the drug can be increased to 4 grams per day.

The instructions note that Cefalexin is prescribed to children only in the form of a suspension. A child under one year old should not be given more than 0.5 g of medication per day. Children whose age ranges from 1 to 6 years are prescribed from 0.5 to 1 gram per day. Children 6-10 years old - 1 gram per day, 10-14 years old - 1-2 grams per day.

The maximum amount of Cefalexin that can be used per day for both children from six years of age and adults is 4 grams per day (for serious illnesses and various complications). The intake of this drug should be divided into parts (4 times a day). In order to quickly recover from infectious diseases caused by streptococci, the course of treatment should last at least 10 days.

How to prepare a suspension of Cefalexin for use

In order to properly prepare the suspension, you need to add 80 ml of water to the vial with the drug (2.5 g) (it is necessary that the water be distilled). Now you can drink the dose you need. 1 ml of suspension contains 25 mg of Cefalexin. A spoon is included with the drug, which will easily measure the dosage that the patient needs to take. Shake the suspension bottle before each use.

Cefalexin: application in the form of capsules

Cefalexin capsules should be used at least half an hour before a meal, or even all forty minutes. Capsules are simply washed down with water (up to 1 glass) and that's it - they should not be chewed.

Dosage for adults and children (who are already 12 years old): if you drink 4 times a day, then you need to use 250 mg of Cefalexin at a time. The break between the use of capsules should be 6 hours. And if you drink 2 times a day, then at one time you need to drink 500 mg of Cefalexin. The break between doses of the drug should be 12 hours.

Most often, the daily dose of Cefalexin does not exceed 1 gram. But in the most difficult situations (infections), an increase in dosage up to 4 grams is allowed.

According to average statistics, the course of treatment lasts from 7 to 14 days, but if the infection is serious and does not recede, then, of course, therapy can continue, but only after the doctor's instructions. Immediately after the disappearance of the symptoms of the disease, you should not stop using Cefalexin. You need to drink this antibiotic in capsules for at least 2-3 more days. Elderly people (if they have impaired renal function) are prescribed a lower dosage for use.

Indications, contraindications, side effects of Cefalexin

Indications for the use of Cefalexin

• In acute and chronic pyelonephritis, cystitis, prostatitis, endometritis, vulvovaginitis, etc. (genitourinary system);
• With bronchitis, acute pneumonia (infections of the upper and lower respiratory tract);
• With angina, acute otitis media, sinusitis, etc. (infections of the ENT organs);
• With furunculosis, abscess, pyoderma, etc. ( purulent infections skin and soft tissues)
• With osteomyelitis.

Contraindications for the use of Cefalexin

• According to the instructions, you can not use Cefalexin in capsules for children who are not yet three years old;
• Also, do not start using this antibiotic because of increased sensitivity to it;
• Cefalexin should be used with great caution in patients with renal insufficiency. Only a doctor can prescribe this drug after passing all the necessary tests;
• Pregnancy and lactation.

Side effects Cephalexin

The instructions for the drug indicate side effects Cephalexin, which may manifest:

• Nausea, vomiting, abdominal pain. If there was a long-term use of Cefalexin, then dysbacteriosis may also begin. After the drug has been discontinued, side effects from its use should also disappear;
• Allergic reactions - rash, urticaria, angioedema;
• Neutropenia, eosinophilia.

How long can Cefalexin be used

As mentioned earlier, according to the average data, the duration of treatment with Cefalexin is from 7 to 14 days. But if the infection occurs with complications, then the course of treatment with the drug can be continued. Only a doctor can rationally assess the situation and attribute proper treatment.

The use of Cefalexin during pregnancy

According to the official instructions, Cefalexin should not be used during pregnancy. It is possible only if the benefit to the mother is slightly higher than the potential risk to the fetus. During lactation, it is also not recommended to start using this drug. If, nevertheless, it was not possible without an antibiotic, then in this case it is better to stop breastfeeding.

Cefalexin: use for children

You can not use the drug for children who are not yet 3 years old, this drug in the form of capsules - it is possible only in the form of a suspension. It is better to use Cefalexin in the form of a suspension up to 10 years inclusive.

Compatibility of Cefalexin with other drugs

The instructions indicate that Cefalexin should not be used in conjunction with furosemide, ethacrynic acid and nephrotoxic antibiotics, as kidney damage may occur. And the combined use with salicylates and indomethacin slows down the process of removing the drug. Also, while taking an antibiotic, you should refuse any alcoholic beverages.

Cefalexin analogues: Russian and foreign

Analogue of Cefalexin - Keflex. It is a first generation antibiotic. It must be taken orally. Thanks to this drug, the walls of bactericidal microorganisms are violated, thereby ridding the body of infection. The analogue of Cefalexin perfectly fights such microorganisms: stalihylococcus slili, strelitococcus lineumoniae, corynebacterium dilihteriae, neisseria meningitidis, neisseria gonorrhoeae, shigella slili, salmonella slili, escherichia coli.

Analogue - Ospeksin. This drug belongs to the antibiotics of the first generation. It must be taken orally. Thanks to this drug, the walls of bactericidal microorganisms are violated, thereby ridding the body of infection. The analogue of Cefalexin perfectly fights such microorganisms: stalihylococcus slili, strelitococcus lineumoniae, corynebacterium dilihteriae, neisseria meningitidis, neisseria gonorrhoeae, shigella slili, salmonella slili, escherichia coli.

Analogue of Cefalexin - Palitrex. This drug belongs to the antibiotics of the first generation. It must be taken orally. Thanks to the use of an analogue of Cefalexin, the walls of bactericidal microorganisms are violated, thereby ridding the body of infection. This analog perfectly fights such microorganisms: stalihylococcus slili, strelitococcus lineumoniae, corynebacterium dilihteriae, neisseria meningitidis, neisseria gonorrhoeae, shigella slili, salmonella slili, escherichia coli.

Analogue - Feleksin. This drug belongs to the antibiotics of the first generation. It must be taken orally. Thanks to this drug, the walls of bactericidal microorganisms are violated, thereby ridding the body of infection. The analogue of Cefalexin perfectly fights such microorganisms: stalihylococcus slili, strelitococcus lineumoniae, corynebacterium dilihteriae, neisseria meningitidis, neisseria gonorrhoeae, shigella slili, salmonella slili, escherichia coli.

The price of Cefalexin

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Cefalexin - instructions, application, reviews

Cefalexin is an antibacterial, bactericidal drug.

Active substance

Cephalexin (Cefalexin).

Release form and composition

Cefalexin is sold in the form of capsules, tablets, granules and powder for oral suspension.

Capsules are available in blisters (8 capsules each), placed in cardboard boxes of 2 pcs.

Tablets are available in blisters (10 tablets each) or glass jars(20 tablets each), placed in cardboard packages of 1 or 2 pcs.

Granules are sold in glass bottles of 40 g each (for the preparation of 100 ml of suspension), placed in cardboard boxes of 1 pc. The kit comes with a measuring spoon with a volume of 5 ml and a risk for a volume of 2.5 ml.

The powder is available in 2.5 g bottles (150 ml each) placed in cardboard boxes of 1 pc. The set comes with a dosing spoon.

Indications

Indications for the appointment of a medication are infections:

• Soft tissues and skin (pyoderma, furunculosis, lymphadenitis, abscess, lymphangitis, phlegmon).
• Upper and lower respiratory tract (tonsillitis, bronchitis, pharyngitis, bronchopneumonia, otitis media, exacerbation of chronic pneumonia, sinusitis, abscess and empyema of the lungs).
• Joints and bones (including osteomyelitis).
• Genitourinary system (vulvovaginitis, pyelonephritis, endometritis, cystitis, gonorrhea, urethritis, epididymitis, prostatitis).

Contraindications

A contraindication to the use of Cephalexin is childhood up to 3 years (for capsules) and hypersensitivity to auxiliary components (including other beta-lactam antibiotics).

The drug is prescribed with extreme caution in pseudomembranous colitis (in the patient's history), kidney failure, during pregnancy and breastfeeding, in infancy up to 6 months (for suspension).

Method of application and dosage

Tablets and capsules. The drug should be taken 30-60 minutes before meals with plenty of water. The dosage regimen is set individually for each patient (taking into account the sensitivity of the pathogen, localization and severity of the infection). At oral administration the average dose for adult patients is 250-500 mg with an interval of 6-12 hours. If necessary, the daily dose is increased to 4-6 g. The duration of the therapeutic course ranges from 7 to 14 days.

In children with a body weight of less than 40 kg, the average daily dose is 25-50 mg / kg, and the frequency of taking the drug is 4 times a day. With a pronounced course of infections, the daily dose can be increased to 100 mg / kg of body weight, and the frequency of administration - up to 6 times a day. For infections caused by group A beta-hemolytic streptococcus, the duration of therapy should be at least 10 days.

Powder and granules. To prepare the suspension, distilled water (80 ml) is added to the vial with the powder. The suspension is dosed with a special measuring spoon having two marks: the upper one corresponds to 5 ml (125 mg), the lower one - 2.5 ml (62.5 mg). 1 ml of the prepared suspension contains 25 mg of cephalexin. Shake the vial before using the drug.

For adult patients with infectious pathologies provoked by microorganisms highly sensitive to the drug, Cefalexin is prescribed orally at a dose of 1-2 g per day. In diseases caused by less sensitive microorganisms, the drug is prescribed at a dose of 2-4 g per day. The total daily dose is at least 1 g.

When prescribing a suspension, children need to be guided by the following scheme:

• From 14 years to 10 years - 1-2 g per day.
• From 10 to 6 years - 1 g per day.
• From 6 to 1 year - 0.5-1 g per day.
• Less than 1 year (body weight up to 10 kg) - 0.5 g per day.

The maximum daily dose for children over 6 years of age and adult patients is 4 g. At the same time, the frequency of taking the medication is 4 times a day.

In infectious diseases caused by streptococci, the duration of the course of treatment is at least 10 days.

Side effects

The use of Cefalexin may cause the following side effects:

• Central nervous system: drowsiness, weakness, headache, agitation, dizziness, convulsions; in isolated cases - hallucinations.
• Digestive system: attacks of nausea, loss of appetite, vomiting, dyspepsia, dry mouth, candidiasis of the oral cavity and intestines, pain in the abdomen, diarrhea; rarely - pseudomembranous enterocolitis; very rarely - hepatitis, cholestatic jaundice.
• Hematopoietic system: very rarely - changes in the pattern of peripheral blood (thrombocytopenia, neutropenia, leukopenia).
• Reproductive system: genital candidiasis, vaginal discharge, vaginitis.
• Urinary system: rarely - interstitial nephritis.
• Laboratory indicators: an increase in prothrombin time, an increase in the activity of liver enzymes and alkaline phosphatase.
• Allergic manifestations: eosinophilia, dermatitis, urticaria, toxic epidermal necrolysis, arthritis, erythema, Stevens-Johnson syndrome, itching of the anus and genital organs, anaphylaxis, skin rashes; rarely - arthralgia, Quincke's edema.

Overdose symptoms: epigastric pain, nausea, hematuria, diarrhea, vomiting.

special instructions

Cefalexin is used with extreme caution in pseudomembranous colitis (including in the patient's history), renal failure.

In patients with hypersensitivity to penicillins, there is a risk of developing an allergy to cephalosporin antibiotics.

During treatment, you should refrain from drinking alcoholic beverages.

During therapy, a false-positive urine reaction to glucose is possible, as well as a positive direct Coombs reaction.

With staphylococcal infections, cross-drug resistance (resistance) between isoxazolylpenicillins and cephalosporins can develop.

In people with functional impairment of the kidneys, cumulation is possible. In this regard, it is necessary to periodically adjust the dosing regimen.

Terms and conditions of storage

Store at a temperature of 15 to 25 °C. Keep away from children. Shelf life - 2 years. The finished suspension is stored at the specified temperature for no longer than 6 days (or in the refrigerator - no more than 14 days).

dolgojit.net

Suspension Cefalexin for children: cheap does not mean bad

When a doctor prescribes the drug Cefalexin to a child, some mothers have questions: why is the price of the medicine suspiciously low, what does “first generation antibiotic” mean, is its release form suitable for treating children?

Let's see in what cases Cefalexin is prescribed and how it is used to treat children.

Cefalexin is an antibiotic that has proven itself as a multifunctional and effective drug.

Cephalosporin I generation - Cephalexin: active ingredient, composition

The discovery of cephalosporins occurred in 1945, when a substrate was isolated from a culture of the fungus, which gave the name to the group. Now there are 70 names of drugs in it. They are effective, well absorbed in the intestine, low toxicity.

There are four generations of cephalosporins. Cefalexin belongs to the drugs of the first, but this does not mean that it is outdated. Each generation differs in the level of antimicrobial activity, i.e. works on different bacteria. Cefalexin is active against streptococci and staphylococci, Escherichia coli and Proteus.

The active substance of Cefalexin suspension for children is a substance of the same name. As auxiliary components, carboxymethylcellulose, citric acid, sugar or powdered sugar, vanillin and raspberry essence are used. The main substance kills bacteria, destroying the cell wall (bactericidal action), and the auxiliary substances give the finished solution a berry-fruit flavor. Pediatricians often use the drug, as it is convenient to use, safe, well tolerated by children and tastes good.

Children like the drug, because it has a fruity taste.

Release form, manufacturers and prices

Cefalexin is available in capsules, tablets and granules.

In Russian pharmacies, gelatin-coated capsules manufactured by Hemofarm (Serbia) and Belmedpreparata (Belarus) are on sale. The cost of the drug, depending on the dosage and form of release, ranges from 62 to 90 rubles.

Capsules manufactured by Hemofarm, regardless of the amount of active ingredient, are packed in 16 pcs. in one box. Capsules 250 and 500 mg differ in color so as not to be confused when using the drug.

Capsules produced by Belmedpreparata are packed in a box of 30 pcs. and have a Cephalexin dosage of only 250 mg.

Capsules must not be opened or cut.

Granules for the preparation of a suspension are supplied to the Russian Federation in bottles for the preparation of 100 ml of a suspension only by Hemofarm (Serbia). The bottle is packed in a cardboard box. The package says 250 mg/5 ml. This means that 5 ml of the finished suspension (one full scoop) contains 250 mg of cephalexin. 100 ml indicates the capacity of the suspension vial.

The granules look like small peas. For the exact dosage of the medicine, a measuring spoon is included with the bottle.

The cost of Cefalexin for the preparation of a suspension starts from 70 rubles. for packing.

Indications for use

Indications for the appointment of Cefalexin:

• bacterial infections respiratory organs (angina, tonsillitis, bronchitis);
• inflammation of the kidneys, bladder (cystitis, pyelonephritis);
• pustular skin processes;
• infections of the joints, bones.

The drug will help with bronchitis.

Instructions for use describe in detail about all diseases.

Download instructions for use in pdf format.

When Cephalexin is Not Needed

Antibiotics do not lower the temperature.

The use of Cefalexin in the diagnosis of ARVI is absolutely useless, as E.O. Komarovsky, talking about mistakes in the use of antibiotics.

The medicine will not affect the prevention of a secondary infection. A secondary infection - an infection that sometimes joins an existing viral and / or bacterial infection - requires additional selection of antibiotics by a doctor.

Cephalexin does not penetrate well into the middle ear. For otitis, it is better to choose Amoxicillin or its protected form - Amoxiclav, you can use their analogue - Flemoxin Solutab.

Flemoxin Solutab will cope with otitis media more effectively than Cefalexin.

Mode of application

To prepare the suspension according to the instructions, you need to use distilled water. 80 ml of liquid is added to the vial and then the contents of the vial are shaken until the powder or granules are completely dissolved.

In the absence of distilled water at hand, drinking water is used at home.

The finished suspension is taken orally, 30-40 minutes before meals. Give your child plenty of water to drink the medicine. If the baby has eaten, this will only affect the rate of absorption, and not the action of Cefalexin.

You need to drink a lot! Even if you don't feel like it.

For the disease to come out.

The finished suspension does not change its properties when stored at room temperature for up to 14 days. You can store the finished suspension no longer than this period.

Do not forget to shake the bottle with the solution before each use.

Give the suspension to the child using the measuring spoon included in the package. It has two labels 2.5 ml (125 mg cephalexin) and 5 ml (250 mg cephalexin), which allows you to accurately dose the medicine.

Depending on age, the average daily dose is:

• children up to a year - up to 0.5 g;
• from 1 year to 6 years - 0.5-1 g;
• from 6 to 14 years old - from 1 to 2 years.

Taking into account the weight, it is calculated based on the severity of the condition - 25-50 mg per 1 kg of the child's weight, in cases of complicated infection - up to 100 mg.

The daily dose of the drug is divided into several doses, depending on the severity of the condition and the type of bacteria that caused the disease. Usually, doctors prescribe Cefalexin to a child 4 times a day. Sometimes they reduce or increase the interval between doses - 2, 3, 6 times a day. Note:

• 2 times means every 12 hours;
• 3 - every 8;
• 4 - after 6 hours.

Try to keep the specified intervals.

Strictly follow the doctor's recommendations.

The dosage of the drug is prescribed by the doctor according to the amount of the active substance. If the doctor has prescribed to take 125 mg 4 times a day, then give the child 2.5 ml of the suspension every 6 hours.

If it is written that 1 g in four doses, then the medicine should be drunk 4 times a day every 6 hours, one measuring spoon of 5 ml each (i.e. 250 mg of cephalexin at a time).

Is it possible to give a child a pill

In what form to give the drug to a child depends on his age and ability to take medication in tablet form. Children under 3 years of age are prescribed Cefalexin exclusively in the form of a suspension.

If the child knows how to take drugs in tablets, can swallow them whole, and his age is over three years old, then when prescribing a single dose of 250 mg of Cefaxelin, capsules can be given.

Please note: they cannot be divided, broken, chewed! The shell protects the active substance from premature contact with body fluids.

Side effects

Taking Cefalexin sometimes causes unwanted effects (side effects):

Some parents report drowsiness in children after taking the medicine.

• the development of thrush, which is accompanied by itching and the presence of white plaque on the mucous membranes;
• a change in the rate of blood clotting - with cuts and abrasions, it is harder to stop the blood from the wound.

Such symptoms disappear on their own after cessation of Cephalaxin and do not require additional intervention.

On the restoration of intestinal microflora in children after antibiotic treatment →

In rare cases, an allergy develops: from a rash to anaphylactic shock. In case of an allergic reaction, stop taking Cephalaxin, give antihistamine(Suprastin, Tavegil). Call your doctor immediately if you develop Quincke's edema or anaphylactic shock.

An allergic reaction of the body is possible - a rash or itching.

Contraindications

Cefalexin is contraindicated in case of intolerance to antibiotics of this group and penicillins, since a cross-allergic reaction is possible. If the child has taken cephalosporins before and has had an allergy, do not give him this group of drugs anymore. Use drugs of the macrolide group (Sumamed, Azithromycin). They must also be prescribed by a doctor.

The tablet form is not suitable for children under 3 years of age.

Cefalaxin is prescribed with caution to infants under 6 months of age.

Interaction with other drugs

Always tell the doctor if your baby is taking any medication:

• The joint use of drugs containing Cefalexin with diuretics and antibiotics that are toxic to the kidneys increases the risk of damage to the urinary system.
• The effect of drugs for blood clotting is increased by taking Cefalexin.
• Anti-inflammatory (salicylic acid) slows down its excretion from the body.

Analogues and prices

Cefalexin is replaced by drugs with similar antibacterial activity. These are analogues:

• from the group of penicillins;
• other cephalosporins of the I-II generation (Ceklor - 600-690 rubles, Zinnat - 220-420 rubles);
• macrolides - Sumamed (198-494 rubles) - can be prescribed for complicated infections.

A more expensive analogue of Cefalexin is Sumamed.

Remember, later generation cephalosporins differ from Cefalexin in their spectrum of activity, as they act on other pathogens, and cannot be a substitute for it (Ceftriaxone, Biotraxone).