Levofloxacin in the treatment of urinary tract infections. Which is better: ciprofloxacin or levofloxacin? Which is safer ciprofloxacin or levofloxacin

Popular in the treatment of infectious inflammatory diseases use fluoroquinolones. Often doctors prescribe Levofloxacin or Ciprofloxacin, a comparison of these drugs will help determine in which cases this or that medication will have a positive effect.

Characteristics of Levofloxacin

Levofloxacin is a synthetically created fluoroquinolone antibiotic. The active substance of the drug is an isomeric analogue of ofloxacin. One tablet contains 250 mg of levofloxacin hemihydrate.

Indications for use are infectious diseases caused by sensitive microflora:

acute sinusitis;
Chronical bronchitis in the acute stage;
pneumonia;
urinary tract infections;
prostatitis;
skin infections;
infections gastrointestinal tract.

The average daily dose for oral intake is 500 mg.

It is not prescribed if the patient has allergic reactions to one of the components that make up the drug.

It is also contraindicated in such clinical pictures:

epilepsy;
tendon problems with fluoroquinols.

Do not use the drug in pediatrics (possibly a violation of the articular cartilage).

Do not take medication during pregnancy breastfeeding.

V rare cases the following negative effects can be observed:

candidiasis;
mycoses;
inflammation and degeneration of the tendon tissue, ruptures;
a decrease in the number of white blood cells, platelets or red blood cells;
anaphylactic shock;
anorexia, hypoglycemia;
sleep disturbance, nervousness, irritability;
taste disorder;
tremor of the limbs;
vertigo, ringing in the ears;
tachycardia, arterial hypotension, prolongation of the QT interval;
bronchospasm, lack of air, allergic pneumonitis;
nausea, vomiting, dyspepsia, diarrhea;
hepatitis, jaundice;
rash, itching, angioedema, hyperhidrosis;
impaired renal function;
asthenia, pyrexia, pain in the chest, back, limbs;
bouts of porphyria.

When using the drug in higher doses than recommended, the following symptoms may appear:

dizziness, loss of consciousness;
convulsions;
prolongation of the QT interval.

In case of an overdose, you should immediately stop taking the medication, consult a doctor, and do an ECG.

Dialysis is ineffective because there is no antidote. Treatment can only be symptomatic.

Characteristics of Ciprofloxacin

The main active ingredient of the drug is ciprofloxacin. The composition of the drug includes auxiliary components: starch, talc, titanium and silicon dioxide, magnesium stearate and lecithin.

Indications for the use of the drug are:

acute bronchitis, exacerbation of the disease in a chronic form;
severe form of tuberculosis;
pulmonary inflammation;
infections that develop as a result of cystic fibrosis;
inflammation of the middle ear - otitis;
sinusitis;
frontitis;
pharyngitis;
tonsillitis;
complicated infections and inflammation of the urinary system;
chlamydia;
gonorrhea;
infectious diseases gastrointestinal tract;
infectious skin lesions, burns, ulcers and a number of others.

The drug can be used in the treatment of postoperative infectious complications.

Ciprofloxacin should not be taken in case of allergic reactions to the main and auxiliary components of the drug, as well as the simultaneous use of tizanidine.

It is contraindicated for pregnant women and lactating women.

Side effects:

liquid stool;
gagging;
eosinophilia;
fungal superinfections;
lack of appetite;
excitation;
hyperactivity;
headache;
taste disorders;
dizziness;
sleep disorders;
flatulence;
pain in the stomach / intestines;
increased activity of liver enzymes;
musculoskeletal pain;
joint pain;
rash, urticaria;
fever, fatigue;
change in the number of leukocytes;
inflammation of the colon;
decrease in the number of platelets;
increase in sugar levels;
allergic reactions;
depression with the appearance of suicidal thoughts;
pathological dreams;
sensitivity changes;
trembling;
convulsions;
visual impairment;
decline blood pressure;
tachycardia;
fainting;
violations of the liver;
suffocation;
jaundice, hepatitis;
intolerance to sunlight (photosensitivity);
increased muscle tone.

If you exceed the dose of the drug, stop taking it and seek medical help.

Overdose symptoms may include:

headache;
fatigue;
confusion;
dizziness;
convulsions;
hallucinations;
feeling of discomfort in the abdomen;
the appearance of crystals, blood in the urine;
kidney/liver dysfunction.

Comparison of drugs

Ciprofloxacin and Levofloxacin are analogue medicines. They are used in the field of pulmonology and otolaryngology. They are used in the treatment of diseases associated with inflammation of the ENT organs, respiratory infections are also no exception. At the same time, the composition of the drugs includes different active substances, so there are differences between the drugs.

similarity

Both medicines belong to antibiotics from a number of fluoroquinolones. Levofloxacin and Ciprofloxacin have a similar purpose, therefore their spectrum of action is identical.

Medicines have the same forms of release:

tablets;
solution (for injections and for infusions);
drops (eye and ear).

The drugs are well tolerated by the body and well absorbed when taken orally. Adverse reactions occur rarely and with the same frequency. The negative consequences are also the same.

What is the difference

Active substance Levofloxacin - levofloxacin, main component Ciprofloxacin - ofloxacin. The first is a new drug, and the second belongs to the first generation drugs, so some of the pathogenic bacteria have developed resistance to it.

The new drug is compatible with other medicines; in Ciprofloxacin, when interacting with other compounds, the activity level decreases.

What is cheaper

Any form of Ciprofloxacin is cheaper than the opponent. For example, the average cost of packing tablets of the first is 80 rubles, the second is 250 rubles.

Is it possible to replace Levofloxacin with Ciprofloxacin

Levofloxacin can be replaced with Ciprofloxacin if the bacteria that caused the disease are susceptible to the latter. Before making a replacement, it is better to consult a doctor.

Which is better - Levofloxacin or Ciprofloxacin

Levofloxacin, being a new generation drug, has a higher efficiency. Some pathogens that are resistant to the opponent cannot resist Levofloxacin. It is more active against Pseudomonas aeruginosa, pneumococcal infection and atypical microorganisms.

In this article we will try to figure out which is better levofloxacin or ciprofloxacin. To give a solid answer, it is necessary to dwell in more detail on the features of the use of each of these drugs separately.

Ciprofloxacin

To the classical fluoroquinolones, which have wide indications for use in respiratory infections of the lower respiratory tract and ENT pathology, includes Ciprofloxacin. Clinical experience shows that this drug is active against gram-negative bacteria, staphylococci and atypical pathogens (chlamydia, mycoplasma, etc.). At the same time, ciprofloxacin is not effective enough in diseases caused by pneumococci.

The selection of the optimal drug for the treatment of any disease should be handled exclusively by a highly qualified doctor.

Indications

Being a broad-spectrum antibacterial drug, Ciprofloxacin is successfully used in the treatment of patients suffering from respiratory infections of the respiratory tract and ENT pathology. What diseases respiratory system and diseases of the ear, throat, nose, use this drug from the group of classic fluoroquinolones:

Acute and chronic bronchitis (at the stage of exacerbation).
Pneumonia caused by various pathogenic microorganisms.
Inflammation of the middle ear, paranasal sinuses, throat, etc.

Contraindications

Like most drugs, Ciprofloxacin has its contraindications. In what situations this representative of classical fluoroquinolones cannot be used in the treatment of respiratory diseases and ENT pathology:

Allergic reaction to ciprofloxacin.
Pseudomembranous colitis.
Childhood and adolescence (until the end of the formation of the skeletal system). An exception is children with pulmonary cystic fibrosis who have developed infectious complications.
Pulmonary form of anthrax.

In addition, patients with the following disorders and pathological conditions have restrictions on the use of Ciprofloxacin:

Progressive atherosclerotic lesion of the blood vessels of the brain.
Severe disorders of cerebral circulation.
Various heart diseases (arrhythmia, heart attack, etc.).
Decreased levels of potassium and/or magnesium in the blood (electrolyte imbalance).
Depressive state.
epileptic seizures.
Severe disorders of the central nervous system (for example, stroke).
Myasthenia.
Serious malfunctions of the kidneys and / or liver.
Advanced age.

Side effects

According to clinical practice, adverse reactions in the vast majority of patients taking fluoroquinolones are observed infrequently. We list the undesirable effects that occur in about 1 out of 1000 patients taking Ciprofloxacin:

Dyspeptic disorders (vomiting, pain in the abdomen, diarrhea, etc.)
Decreased appetite.
Feeling of heartbeat.
Headache.
Dizziness.
Periodic sleep problems.
Changes in the main blood parameters.
Weakness, fatigue.
Allergic reaction.
Various skin rashes.
Pain in muscles and joints.
Functional disorders of the kidneys and liver.

Do not buy Levofloxacin or Ciprofloxacin without first talking to your doctor.

special instructions

With extreme caution, ciprofloxacin is prescribed to patients who are already taking drugs that lead to a prolongation of the QT interval:

Antiarrhythmic drugs.
Macrolide antibiotics.
Tricyclic antidepressants.
Antipsychotics.

Clinical observations show that Ciprofloxacin enhances the effect of hypoglycemic drugs. With their simultaneous use, careful monitoring of blood glucose should be carried out. It has been recorded that drugs that reduce acidity in the gastrointestinal tract (antacids), and which contain aluminum and magnesium, reduce the absorption of fluoroquinolones from the digestive tract. The interval between the use of an antacid and an antibacterial drug should be at least 120 minutes. I would also like to note that milk and dairy products can affect the absorption of Ciprofloxacin.

In case of an overdose of the drug, headache, dizziness, weakness, convulsive attacks, dyspeptic disorders, functional disorders of the kidneys and liver may develop. There is no specific antidote. Wash the stomach, give activated charcoal. If necessary, symptomatic therapy is prescribed. Carefully monitor the patient's condition until complete recovery.

Levofloxacin

Levofloxacin is a third-generation fluoroquinolone. It has a high activity against gram-negative bacteria, pneumococci and atypical pathogens of respiratory infections. Most pathogens that show resistance (resistance) to the "classic" second-generation fluoroquinolones may be susceptible to more modern drugs such as Levofloxacin.

Eating does not affect the absorption of Ciprofloxacin or Levofloxacin. Modern fluoroquinolones can be taken both before and after meals.

Indications

Levofloxacin is an antibacterial drug with a wide spectrum of action. It is actively involved in the following diseases respiratory system and ENT organs:

Acute or chronic inflammation bronchi (at the stage of exacerbation).
Inflammation of the paranasal sinuses (sinusitis, sinusitis, etc.).
Infectious and inflammatory processes in the ear, throat.
Pneumonia.
Infectious complications of cystic fibrosis.

Contraindications

Despite the fact that Levofloxacin belongs to the new generation of fluoroquinolones, this drug can not be prescribed in all cases. What are the contraindications to the use of Levofloxacin:

An allergic reaction to a drug or its analogues from the fluoroquinolone group.
Serious kidney problems.
epileptic seizures.
Tendon injury associated with prior fluoroquinolone therapy.
Children and teenagers.
Periods of childbearing and breastfeeding.

Levofloxacin should be used with extreme caution in elderly patients.

Side effects

As a rule, all adverse reactions are classified according to severity and frequency of occurrence. We list the main undesirable effects from taking Levofloxacin, which may occur:

Problems with the functioning of the gastrointestinal tract (nausea, vomiting, diarrhea, etc.).
Headache.
Dizziness.
Allergic reactions (skin rashes, itching, etc.).
Elevated levels of essential liver enzymes.
Drowsiness.
Weakness.
Pain in muscles and joints.
Damage to the tendons (inflammation, tears, etc.).

Self-administration of Levofloxacin or Ciprofloxacin without the permission of the attending physician can have serious consequences.

special instructions

Since the likelihood of joint damage is high, Levofloxacin is not prescribed for children and children. adolescence(up to 18 years), except in extremely severe cases. When using antibacterial drugs for the treatment of age-related patients, it should be borne in mind that this category of patients may have impaired renal function, which is a contraindication for the appointment of fluoroquinolones.

During therapy with Levofloxacin, patients who have previously suffered a stroke or severe traumatic brain injury may develop epileptic seizures (convulsions). If there is a suspicion of the presence of pseudomembranous colitis, it is necessary to immediately stop taking Levofloxacin and prescribe the optimal course of therapy. In such situations, it is strongly not recommended to use drugs that inhibit intestinal motility.

Although rare, there may be cases of inflammation of the tendons (tendinitis) when using Levofloxacin. Older patients are more prone to these types of side effects. Concurrent use of glucocorticosteroids significantly increases the risk of developing tendon ruptures. If a tendon lesion is suspected (inflammation, ruptures, etc.), fluoroquinolone therapy is stopped.

With an overdose of this drug symptomatic therapy should be carried out. The use of dialysis in such cases is ineffective. There is no specific antidote.

During therapy with Levofloxacin, it is not recommended to engage in activities that require increased concentration and quick reaction (for example, driving a car). Also, due to the risk of developing photosensitivity, refrain from excessive skin exposure to ultraviolet rays.

What drug to choose?

How to determine which is better Levofloxacin or Ciprofloxacin? Definitely do best choice can only be done by an experienced professional. Nevertheless, when choosing a drug, it is necessary to rely on 3 main aspects:

A good drug will be considered one that is not only effective, but also less toxic and affordable. In terms of effectiveness, Levofloxacin has its advantages over Ciprofloxacin. Along with the preserved activity against gram-negative pathogenic microorganisms, Levofloxacin has a more pronounced antibacterial effect against pneumococci and atypical pathogens. However, it is inferior to Ciprofloxacin in activity against the pathogen Pseudomonas (P.) aeruginosa. It has been noted that pathogens that are resistant to ciprofloxacin may be susceptible to levofloxacin.

Type of pathogen and its susceptibility to antibacterial agents are decisive when choosing the optimal fluoroquinolone (in particular, Ciprofloxacin or Lefovloxacin).

Both drugs are well absorbed in the intestine when taken orally. Food practically does not affect the absorption process, with the exception of milk and dairy products. They are convenient to use because they can be administered 1-2 times a day. Regardless of whether you take Ciprofloxacin or Levofloxacin, in rare cases, unwanted side effects may develop. adverse reactions. As a rule, dyspeptic disorders (nausea, vomiting, etc.) are noted. Some patients taking fluoroquinolones of the second or third generation complain of headache, dizziness, weakness, fatigue, sleep disturbance.

In elderly patients, especially against the background of glucocorticosteroid therapy, tendon ruptures are possible. Due to the risk of developing joint damage, fluoroquinolones are limited in use during periods of childbearing and breastfeeding, as well as in childhood.

Currently, for most patients, the price aspect is of paramount importance. A pack of Ciprofloxacin tablets costs about 40 rubles. Depending on the dosage of the drug (250 or 500 mg), the price may fluctuate, but not significantly. A more modern Levofloxacin will cost you an average of 200-300 rubles. The price will depend on the manufacturer.

However, the final decision as to what is best for the patient Ciprofloxacin or Levofloxacin is made solely by the attending physician.

Levofloxacin: analogues, review of essential drugs similar to Levofloxacin

According to the latest medical statistics, the spread of prostatitis and its forms has recently begun to increase. The reasons for this situation can be called a lot of factors, among which, the main place is occupied by the unsatisfactory attitude of a man to his health, poor ecology, poor-quality food, etc.

Therefore, it is not surprising how seriously pharmacologists have to work to offer patients the latest and most effective drugs for the treatment of prostatitis. Among those, there is also Levofloxacin - an antibiotic latest generation, with a wide spectrum of action.

This type of drug, like Amoxiclav, belongs to antibiotics with a wide spectrum of action and is ideal for the systemic treatment of various diseases, including prostatitis (acute, chronic, bacterial).

The release form of the drug is tablets or solutions for injection. Any form of the drug is quickly absorbed into the blood, affects the body at the cellular level, and the directed action of the drug allows you to effectively kill entire colonies of harmful microorganisms. For people suffering from infectious and bacterial diseases, it will be much cheaper to purchase such a medication than buying other antibiotic synonyms and substitutes, which also have side effects and contraindications.

Levofloxacin analogues have the following properties:

They have a wide and active spectrum of effects on the body.
Able to quickly penetrate into the tissues of the prostate.
Show a high degree of activity and directional action.

Before taking the medicine, you should read all the information that the instructions for taking the drug offer you. Like any other antibiotic, domestic or imported, Levofloxacin can cause side effects and individual intolerance.

Today you can choose not only Levofloxacin, analogues of this drug, similar in composition, action and form of release, are presented on the market in large quantities.

Tavanik - the same effective antibiotic, which is prescribed for various diseases. Characterized by a high degree of drug activity and impact on groups of harmful microorganisms, its use allows you to get positive results of treatment in the most short time therapy. The price of the product depends on the form of release: tablets can be bought from 600 rubles, an injection solution will cost you 1620 rubles.

Ciprofloxacin is an active antibiotic with a wide spectrum of action. Used to treat infectious diseases internal organs and tissues, in particular - the genitourinary system. The drug is produced in various forms, for example, these are eye drops, suspensions and solutions for injections, tablets and capsules. The cost of an antibiotic is low, from 18 rubles, and any pharmacy can offer you this drug.

Along with the Russian analogues discussed above, there are also foreign analogues of Levofloxacin on the market that can defeat any infectious disease.

Elefloks, produced by an Indian pharmaceutical company, is actively used to treat various forms of prostatitis, inhibits the activity of harmful microorganisms. It is used in systemic treatment, in which the disease is quickly treatable.

Glevo - a product of Indian pharmacology, with a wide spectrum of action, is excellent for the treatment of all forms of prostatitis.

Levofloxacin belongs to the group of fluoroquinols. To the same group with the active substance levofloxacin belong:

All antibiotics of this group are very effective in the treatment of prostatitis. Therefore, your choice of a drug can only be influenced by your individual intolerance to the components of one of them, the severity of the disease, in which it is necessary to apply complex treatment in which not all antibiotics may be compatible with other drugs. All drugs have detailed instructions, after reading which you will find out what side effect you can expect, what contraindication in your case may affect the choice of remedy.

Tavanic or Levofloxacin which is better?

As we have already noted, both of these drugs belong to the group of fluoroquinols, with an active active ingredient - levofloxacin, which quickly penetrates into the blood, then it is taken by the plasma and distributed to all tissues of the body.

The drug Levofloxacin has an active effect on various areas of tissues affected by harmful microorganisms, and it acts directly at the cellular level, which speeds up treatment and gives positive results. With prostatitis, different groups of bacteria may be present in the body, affecting the organ and disease-causing: anaerobic gram-positive and gram-negative, simple microorganisms and chlamydia. With all these "pests" the drug fights very effectively.

Tavanic is the latest generation antibiotic with high rates effectiveness in the treatment of diseases of various internal organs, bone tissue.

The active substance in the drug is levofloxacin, auxiliary - crospovidone, cellulose, titanium dioxide, macrogol 8000, iron oxide red and yellow. When taking the drug, its concentration in the blood lasts for a rather long period.

The antibacterial drug gives the fastest and most positive results in the treatment of various forms of prostatitis, ranging from mild to chronic, as it affects tissue cells, their membranes and walls. It is especially effective in complex treatment, because. its active and active component, levofloxacin, interacts well with other drugs.

If we compare Tavanic or Levofloxacin, which is better, then the first drug has fewer side effects and has more quick action and the range of its influence is much wider.

Comparing the cost of drugs, it can be noted that you can buy Levofloxacin at a price of 77 rubles, and Tavanic - from 590 rubles.

Most often, when the doctor has prescribed a course of treatment with this drug, the patient is prescribed 2 doses.

The average daily dose of the drug at each dose is from 500 ml to 1 g, depending on the form of the disease, the prostate gland is in. If injections are prescribed, then the daily dose of liquid is from 250 to 500 ml, depending on the severity of the disease. The medicine is taken regardless of the meal, because. mucosa quickly absorbs the substances of the drug.

With mild forms of prostatitis, as well as with diseases that affect the bronchi, the course of treatment can be from 14 to 28 days. In this case, the daily dose is from 500 ml to 1 g.

To decide whether Tavanic or Levofloxacin, which is better, the attending physician will help you, who will select the best antimicrobial drug for effective therapy.

Levofloxacin or Ciprofloxacin: a comparative evaluation of drugs

The drug has a wide spectrum of action, inhibits the vital activity of various microorganisms, quickly penetrates into the bloodstream, is distributed throughout the tissues of the body, and any infection is amenable to such therapy.

The doctor prescribes the drug, which calculates the daily dose of the drug.

The course of treatment can be from 1 to 4 weeks, depending on the degree of the disease.

If we consider Levofloxacin and Ciprofloxacin, the difference lies in the fact that the first is more effective, it can interact with other drugs, while Ciprofloxacin, under the influence of other drugs, can reduce its concentration and activity, which delays the course of treatment.

Both drugs, Levofloxacin and Ciprofloxacin, are antibiotics that should only be taken on the advice of a doctor who considers each clinical case on an individual basis.

The main difference between the two antibiotics is the active substance: in the first preparation it is levofloxacin, and in the second it is ofloxacin. Under the action of Ofloxacin, not all groups of bacteria can be destroyed, since microorganisms have a different degree of sensitivity to ofloxacin, so the treatment of prostatitis may be different due to the causes of the disease and the effectiveness of treatment may also differ.

Levofloxacin Astrapharm: description of the drug and its distinctive features

Distinctive features from Levofloxacin

Levofloxacin Astrapharm is able to inhibit the activity of gram-positive and gram-negative microbes, while Levofloxacin acts on all groups of bacteria.

Most often, Levofloxacin Astrapharm is used for effective treatment bacterial chronic prostatitis.

In therapy with Levofloxacin, a positive trend is observed already in the middle of treatment, and this occurs regardless of the form of the disease.

If we talk about Levofloxacin Astrapharm blister, then it is more effective in the treatment of mild and moderate forms of prostatitis.

Regardless of what choice you make in the treatment of prostatitis, you must remember that only a systemic, well-chosen treatment can give positive dynamics and results.

Specialty: Urologist Work experience: 21 years

Specialty: Urologist-andrologist Work experience: 26 years

Levofloxacin: analogues of the active substance, features of the therapeutic effect and indications for admission

According to the instructions for use, Levofloxacin is an original broad-profile antibiotic that is active against a number of pathogens of infectious processes in the human body.

The drug Levofloxacin, analogues of which can be presented in different forms of release, can be effectively used in diseases of the ENT system. Thus, quite often this drug is prescribed to patients with otitis media, sinusitis, sinusitis, pharyngitis, etc. The active substance of this medicine will be no less effective in relation to skin infectious lesions, as well as diseases of the urinary and reproductive systems (prostatitis, pyelonephritis, chlamydia, etc.).

According to statistics, today Levofloxacin has several medicinal analogues, which can be presented in the form of drops and tablets, and also have a cheaper price. Reviews of these drugs can be read on numerous patient forums. At the same time, more than 60% of adults are regularly exposed to infectious lesions. different systems organism, so the need for the use of Levofloxacin today is more than in demand.

Levofloxacin is produced, analogues of which also have a wide therapeutic spectrum of action, in the form of tablets, injections, and eye drops. As for the pharmacological effect, this drug is a potent antibiotic that helps to destroy pathogenic infectious foci.

Levofloxacin is contraindicated, as well as its main substitutes, during pregnancy, childhood, severe kidney and liver diseases. Elderly people should take such a drug strictly under the supervision of a doctor.

Analogues

All analogues of Levofloxacin (synonyms for the therapeutic effect) are divided into two separate subgroups:

Analogues for the active substance of the drug.
Analogues for the pharmacological group.

By active substance

Analogues of Levofloxacin, which will be presented below, can be prescribed for the treatment of pneumonia, sinusitis, protracted bronchitis, various urological lesions, as well as pyelonephritis. It is forbidden to prescribe such drugs to children under eighteen years of age, pregnant women, as well as in case of individual intolerance to the active substance of the drug by a person.

The most effective analogues of Levofloxacin (according to the active substance) are:

Levofloxacin, as well as generics, should be taken in the morning before meals. In acute infectious lesions, the permissible dosage of the drug is 250 mg (1 tablet per day). The duration of therapy is determined by the attending physician. On average, it takes five to ten days to completely suppress the infection.

As for the side effects of Levofloxacin analogues, compared to the previous generation drugs, these drugs are much better tolerated and provoke adverse reactions in no more than 1.5% of all cases. At the same time, patients may experience nausea, abdominal pain, improvement in the functioning of the heart, kidneys and digestive system.

By generation of quinolones

A striking analogue of Levofloxacin in the generation of quinolones is the drug Sparfloxacin. Also, like Levofloxacin, it belongs to the last, third generation of antibiotics. This drug is most effective in relation to gram-negative foci of infection, in particular, to staphylococci.

Sparfloxacin is prescribed for the same indications of the patient as Levofloxacin (analogues can be prescribed by a doctor). Thus, such an antibiotic can be used to treat chlamydia, leprosy, inflammatory diseases of the urethra and respiratory system.

As for contraindications, in addition to the standard prohibitions that are attributed to Levofloxacin, Sparfloxacin also has a ban in the form of bradycardia and hepatitis.

The price for such an analogue of the drug is 340 rubles per package (6 tablets).

Tavanic or Levofloxacin: which is better, characteristics and features of the best antibiotic analogues

One of the most popular foreign analogues of Levofloxacin is Tavanic, which is produced by a French manufacturer. Many patients do not know whether Tavanic or Levofloxacin is better.

With a detailed study of both these drugs, it should be said that, unlike Levofloxacin, Tavanic has only one dosage form of release (solution for infusion). This is the downside of this drug.

Tavanic or Levofloxacin (which is better for adults, the attending physician should decide in each case) have very similar indications for use, since both drugs are approved for use in prostatitis, sinusitis, respiratory and genitourinary infections. Moreover, both drugs are available for sale in pharmacies.

When asked whether Tavanic or Levofloxacin is better, it is also important to note the cost of the first drug, which can reach up to 1200 rubles, which will be significantly higher than the average price for Levofloxacin.

Another analogue of Levofloxacin, which has a similar therapeutic effect, is the drug Moxifloxacin. It has a pronounced antibacterial effect against infectious pathogens of different classes.

Compared with Levofloxacin, Moxifloxacin has the following advantages:

The drug has a wider spectrum of action.
Does not provoke allergies when exposed to ultraviolet radiation.
It can be used in conjunction with other antibiotics without causing negative reactions.

In turn, the following disadvantages of this analogue are distinguished in comparison with Levofloxacin:

Less effective for infections of the urinary system.
It does not have complete reception security.
It has a large list of contraindications.
It has a bad effect on the metabolism of vitamins when taken.

As for eye drops, Levofloxacin in this form of release has analogues in the form of Floxal, Signicef and Ofloxacin. The use of these drugs is allowed only as prescribed by a doctor, with strict adherence to the dosage. If it is necessary to treat children, it is important that the therapy is supervised by a specialist.

Remember that self-medication is dangerous for your health! Be sure to consult with your doctor! The information on the site is presented for informational purposes only and does not claim to be a reference and medical accuracy, is not a guide to action.

Articles

The most common causative agents of CP are representatives of the gram-negative bacteria Enterobacteria ceae, which come from the gastrointestinal tract. The most common strains are Escherichia coli, which are found in 65-80% of infections. Pseudomonas aeruginosa, Serratia spp., Klebsiella spp. and Enterobacter aerogenes, and Acinetobacter spp. are detected in 10-15%. Enterococci account for 5 to 10% of confirmed prostate infections. When examining patients with chronic pancreatitis, ureaplasmas, mycoplasmas, chlamydia, trichomonas, gardnerella, anaerobes, fungi of the genus Candida are increasingly found, which are among the likely causative agents of this disease.

Fluoroquinolone of the 3rd generation, levofloxacin - REMEDIA (Simpex Pharma Pvt Ltd.) - has a wide spectrum of antimicrobial activity. It is included in a new group of fluoroquinolones, which, along with high activity against many gram-negative bacteria, is characterized by increased activity against gram-positive microbes, atypical microorganisms and anaerobes.

It is known that CP leads to significant impairments in the quality of life of men and, in addition to the syndrome of pelvic pain and urinary disorders, can become one of the causes of sexual dysfunction and have a depressing effect on male fertility.

Proven uropathogens in chronic bacterial prostatitis (CKD) are representatives of the family of gram-negative bacteria, to a lesser extent - gram-positive microorganisms.

The issue of the role of nonclostrid and facultative anaerobic bacteria in the development of prostatitis is discussed. There is still no complete clarity regarding atypical pathogens such as chlamydia, ureaplasma, mycoplasma, which are unproven, but likely causes in the initiation of CP.

It has been established that only fluoroquinolone antibiotics, alpha 1-blockers and non-steroidal anti-inflammatory drugs meet the requirements of evidence-based medicine in the treatment of patients with CP.

The purpose of the study: to evaluate the efficacy and safety of the fluoroquinolone levofloxacin (trade name Remedia) in the treatment of CKD and CP

BRANDSof 19

Oh, this is not an easy choice! What is better - Ciprofloxacin or Levofloxacin?

In the treatment of diseases of the respiratory system, fluoroquinolone antibiotics are widely used.

They are highly effective and have a wide spectrum of action. Among the most popular drugs are Ciprofloxacin and Levofloxacin.

These analogue medicines are successfully used in the field of pulmonology and otolaryngology. With their help, ailments associated with inflammation of the ENT organs, pulmonary diseases and respiratory tract diseases are treated. Respiratory infections are no exception.

Both drugs are successfully used in the treatment of progressive forms of tuberculosis. To understand which remedy is better, it is advisable to consider in more detail the features of each of them and compare the effectiveness of the drugs.

Ciprofloxacin

Ciprofloxacin is a classic fluoroquinolone showing increased activity against staphylococci and chlamydia. As for diseases that develop as a result of pneumococcal infection entering the body, the drug is ineffective in their regard.

Photo 1. Packing Ciprofloxacin in the form of tablets with a dosage of 250 mg. Producer "OZ GNTsLS".

Ciprofloxacin is prescribed for tuberculosis of the respiratory system. In some cases, complex treatment is carried out with Pyrazinamide, Streptomycin and Isoniazid. It has been clinically proven that monotherapy against tuberculosis is less effective.

Indications for use

Absolute indications for the use of Ciprofloxacin are:

acute bronchitis, and exacerbations of the disease in a chronic form;
severe form of tuberculosis;
pulmonary inflammation;
infections that develop as a result of cystic fibrosis;
inflammation of the middle ear - otitis;
sinusitis;
frontitis;
pharyngitis;
tonsillitis;
complicated infections and inflammation of the urinary system;
chlamydia;
gonorrhea;
infectious diseases of the gastrointestinal tract;
infectious skin lesions, burns, ulcers and a number of others.

The drug can be used in the treatment of postoperative infectious complications.

The main active ingredient of the drug is ciprofloxacin. The composition of the drug includes auxiliary components: starch, talc, titanium and silicon dioxide, magnesium stearate and lecithin. The drug has several forms of release: tablets, solutions for injection and infusion.

Ciprofloxacin has its contraindications and side effects. In most cases, the drug is easily tolerated, but while taking it, there may be:

allergic reactions;
edema vocal cords;
anorexia;
leukopenia;
agranulocytosis;
thrombocytopenia;
kidney failure;
the occurrence of pain in the abdomen;
stool disorder;
insomnia;
violation of taste perceptions;
headache;
exacerbation of epilepsy.
individual intolerance to its individual components;
hypersensitivity to ciprofloxacin.

The drug is not prescribed to women during pregnancy and lactation, as well as to children under 15 years of age. Antibiotics should be used with caution in renal failure.

Levofloxacin

Levofloxacin is a third generation fluoroquinolone. The drug shows high efficiency in relation to pneumococcal, atypical respiratory and gram-negative bacterial infection. Even those pathogens that are fairly resistant to second-generation antibacterial fluoroquinolones are susceptible to Levofloxacin.

Photo 2. Packing of Levofloxacin in the form of tablets with a dosage of 500 mg. Producer "Teva".

The drug is used in pulmonary tuberculosis. The spectrum of its action in this regard is completely identical to Ciprofloxacin. When conducting monotherapy, clinical improvement in patients is observed after about a month.

Indications for use

Indications for the use of Levofloxacin are:

exacerbation of bronchitis;
inflammatory processes in the paranasal sinuses, characterized by a complicated course, for example, sinusitis;
pulmonary inflammation of any form;
inflammatory processes of the infectious nature of the ENT organs;
infections that develop against the background of cystic fibrosis;
inflammation of the genitourinary system: pyelonephritis, inflammation of the prostate, chlamydia;
soft tissue abscesses;
furunculosis.

The active substance of the drug is the chemical component of the same name - levofloxacin. The composition of the drug contains additional components: cellulose, sodium chloride, dihydrate, disodium edetate, titanium dioxide, iron oxide, calcium stearate.

Levofloxacin has several forms of release. Today, in domestic pharmacies, you can buy drops, tablets and a solution for infusion.

Contraindications and side effects

Like any other drug, fluoroquinolone Levofloxacin has a number of side effects:

allergy to individual components of the drug;
violation of the functional features of the gastrointestinal tract;
headache accompanied by dizziness;
muscle and joint pain;
feeling tired, drowsiness;
inflammation of the tendons;
acute liver failure;
depression;
rhabdomyolysis;
neutropenia;
hemolytic anemia;
asthenia;
exacerbation of porphyria;
exacerbation of epilepsy;
development of a secondary infection.

Contraindications to taking the drug are:

a tendency to develop an allergic reaction to individual medicinal components, i.e. individual intolerance;
unhealthy kidneys;
epilepsy;
drug-induced tendon injury associated with treatment with fluoroquinolone antibacterial drugs.

Levofloxacin is not prescribed to women during pregnancy and while breastfeeding, as well as to children and adolescents. Caution should be exercised by patients with renal pathologies and geriatric patients.

In case of drug overdose, it is suggested to carry out symptomatic treatment. Dialysis is not very efficient.

During the therapeutic course, it is not advisable to drive a car and engage in other activities that require a quick reaction and heightened attention.

Given the likelihood of photosensitivity, it is recommended to stay as little as possible under the influence of direct sunlight.

Which is better: Ciprofloxacin or Levofloxacin? How are antibiotics different?

In order not to make a mistake in the choice and purchase one of the above drugs, it is necessary to determine which one is better. Far from superfluous in resolving this issue will be the advice of a specialist. When evaluating an antibacterial agent, it is necessary to build on the following criteria:

Comparison of drugs: which is more effective

Levofloxacin and Ciprofloxacin have a similar purpose, that is, their spectrum of action is identical, but the first drug has a number of advantages in terms of effectiveness.

The active substance of Ciprofloxacin is ciprofloxacin, Levofloxacin contains the main component levofloxacin.

Unlike Ciprofloxacin, the antibacterial effect of Levofloxacin against pneumococcal infections and atypical microorganisms is more pronounced. The drug remains active against gram-negative bacteria.

It is known that some pathogens that are not sensitive to Ciprofloxacin show instability before exposure to Levofloxacin. The latter drug is more active against Pseudomonas (P.) aeruginosa.

The variety of bacteria and the degree of its sensitivity is the determining factor in the selection medicinal product.

Photo 3. Packing of Levofloxacin in the form of a solution for intravenous infusion at a dosage of 5 mg / ml. Producer "Belmedpreparaty".

Both fluoroquinolones are well tolerated by the body, have excellent oral absorption, and have been successfully used as an effective anti-tuberculosis agent. Levofloxacin shows greater effectiveness in this regard, because it is used in the form of intravenous injections.

The concentration of the active substance in the tablets is less than in the second preparation. Levofloxacin is more often prescribed as the only drug for monotherapy. Eating does not matter during treatment. Both those and other tablets can be taken both before and after meals.

As for adverse reactions, they occur rarely and with the same frequency when taking both Levovloxacin and Ciprofloxacin. Undesirable effects are similar in their manifestations. Patients taking these fluoroquinolones may experience the following:

bouts of nausea accompanied by vomiting;
headache;
dizziness;
fast fatigue, fatigue;
insomnia.

Contraindications for taking both drugs are identical.

Price difference

As for the price, Ciprofloxacin is more affordable. One pack of medicine (500 mg) can be bought at a pharmacy for 80 rubles. Levofloxacin will cost at least 250 rubles per pack. Both drugs are sold exclusively by prescription.

Useful video

Watch a video that tells about the features of the antibiotic Levofloxacin: indications for use, dosages, side effects, compatibility with other drugs.

igor - Features of treatment with Amoxicillin: how many days to take an antibiotic to defeat the disease? 5
Irina - Instructions for using Kanamycin: how not to make a mistake with the dosage 4
Petya - Instructions for using Kanamycin: how not to make a mistake with the dosage 4
Gene - Antibiotic Amikacin: instructions for use, contraindications and side effects 3
Vasily - Instructions for use Amikacin: how to dilute injections 6

Online journal about tuberculosis, lung diseases, tests, diagnostics, medicines and other important information about it.

The group of fluoroquinolones, to which the antibiotic Ciprofloxacin belongs, appeared relatively recently. The first drug of this type began to be used only in the 1980s. Previously, antibacterial agents of this class were prescribed only for urinary tract infections. But now, due to their broad antimicrobial activity, fluoroquinolones, including the antibiotic Ciprofloxacin, are prescribed for bacterial pathologies that are difficult to treat, or for an unidentified pathogen.

The mechanism of the bactericidal action of this drug is based on the penetration of a pathogenic microorganism through the cell membrane and the effect on reproduction processes.

Fluoroquinolones inhibit the synthesis of bacterial enzymes that determine the twisting of the DNA strand around nuclear RNA, this is type I topoisomerase in gram-negative bacteria and class IV topoisomerase in gram-positive ones.

The antibiotic Ciprofloxacin is active against a wide range of bacteria that are resistant to most antimicrobial drugs (Amoxicillin and its more effective analogue Amoxiclav, Doxycycline, Tetracycline, Cefpodoxime and others).

As indicated in the instructions for use, the following strains of bacteria are sensitive to the action of Ciprofloxacin:

golden and saprophytic staphylococcus aureus;
the causative agent of anthrax;
streptococcus;
legionella;
meningococcus;
yersinia;
gonococcus;
hemophilic bacillus;
moraxella.

E. coli, enterococci, pneumococci and some strains of Proteus have moderate sensitivity. Resistant to the action of the antibiotic Ciprofloxacin are mycoplasmas and ureaplasmas, listeria and other, infrequent bacteria.

The drug belongs to the second generation fluoroquinolones, while its analogue of the same group, no less common Levofloxacin, belongs to the third generation and is more used for the treatment of diseases of the respiratory tract.

The advantage of the antibiotic Ciprofloxacin is a wide choice of forms of release. So, for the treatment of bacterial eye infections to reduce the risk of systemic side effects, the drug is prescribed in the form of eye drops. At serious illnesses Ciprofloxacin injections are needed, or rather, infusions, the standard dosage is 100 mg - 200 mg / 100 ml. After normalization of the patient's condition, the patient is transferred to tablets (they are available with a concentration of the active ingredient of 250 and 500 mg). Accordingly, the price of the drug also differs.

The main ingredient of the drug is ciprofloxacin, the presence of excipients depends on the specific form of release of the antibiotic. In the solution for infusions, it is purified water and sodium chloride, in eye drops - various solvents and stabilizers, in tablets - talc, silicon dioxide, cellulose.

The antibiotic Ciprofloxacin is prescribed for children from 5 years of age and adults to treat such diseases:

lesions of the lower respiratory tract, including pneumonia, caused by flora sensitive to fluoroquinolones;
infections of ENT organs, including tonsillitis, otitis media, sinusitis;
diseases of the genitourinary system, for example, cystitis, pyelonephritis, urethritis, gonorrhea, bacterial prostatitis, adnexitis;
various intestinal infections (shigellosis, salmonellosis, typhoid fever, cholera, enteritis, colitis);
sepsis, peritonitis;
infections affecting skin, soft tissues, bones and cartilage, bacterial complications after burns;
anthrax;
brucellosis;
yersiniosis;
borreliosis;
tuberculosis (as part of complex therapy);
specific prophylaxis of bacterial infections in patients with immunodeficiency on the background of HIV or AIDS or the use of cytostatics.

In the form of eye drops, the antibiotic Ciprofloxacin is prescribed for infections of the mucous membrane of the organs of vision. According to experts, cases of development of resistance of the bacterial flora to the action of the drug have not been identified to date. But fluoroquinolones are classified as unsafe drugs, so they are not considered as first-line drugs for the treatment of uncomplicated bacterial infections.

Ciprofloxacin intramuscularly and in the form of eye drops and tablets

When taken orally, the antibiotic is absorbed fairly quickly, mainly these processes occur in the lower parts of the digestive tract. The maximum concentration is reached in an hour and a half after the use of Ciprofloxacin tablets. The overall bioavailability of the drug is high and is about 80% (the exact concentration of the active ingredient in the body depends on the dose taken).

Only dairy products affect the absorption of the antibiotic, so they are advised to be excluded from the diet for the duration of treatment. Otherwise, food intake somewhat slows down the absorption of Ciprofloxacin, but the bioavailability indicators do not change.

With plasma proteins, the active component of the drug binds only 15-20%. Basically, the antibiotic is concentrated in the organs of the small pelvis and abdominal cavity, saliva, lymphoid tissue of the nasopharynx, and lungs. Ciprofloxacin is also found in synovial fluid, bone and cartilage tissue.

The drug enters the spinal canal in a small amount, so it is practically not prescribed for damage to the central nervous system. Approximately one third of the total dosage of Ciprofloxacin is metabolized in the liver, the rest is excreted by the kidneys in unchanged form. The half-life is 3-4 hours.

The exact amount of medication prescribed, as well as the duration of treatment, depends on many factors. First of all, it is the condition of the patient. The standard recommendation regarding the use of any antibacterial agent is to continue taking it for at least three days after the temperature has returned to normal. This applies to both oral forms and the use of Ciprofloxacin intramuscularly.

For adults, the dosage of the drug is 500 mg twice a day, regardless of the meal.

The annotation to the drug indicates average duration therapy:

with diseases of the respiratory tract - up to two weeks;
with lesions of the digestive system from 2 to 7 days, depending on the severity clinical picture and infectious agent
in diseases of the genitourinary system, prostatitis therapy lasts the longest - up to 28 days, to eliminate gonorrhea, a single dose is sufficient, with cystitis and pyelonephritis, treatment is continued up to 14 days;
with infections of the skin and soft tissues - an average of two weeks;
with bacterial lesions of bones and joints, the duration of therapy is determined by the doctor and can last up to 3 months.

Important

The severe course of the infection is an indication for increasing the daily dosage for an adult to 1.5 g.

Important

The maximum daily dosage of the drug in childhood should not exceed 1.5 g per day.

Ciprofloxacin is not used intramuscularly. The antibiotic solution is administered only intravenously. At the same time, its action develops much faster than that of tablets. The maximum plasma concentration is reached after 30 minutes. The bioavailability of the Ciprofloxacin solution is also higher. With intravenous injections, it is almost completely excreted unchanged by the kidneys within 3-5 hours.

Unlike tablets, for many uncomplicated bacterial diseases, one infusion of Ciprofloxacin is sufficient. In this case, the daily dosage for adults is 200 mg or two injections during the day. The required amount of the drug for a child is determined in the proportion of 7.5-10 mg / kg per day (but not more than 800 mg per day).

The ready solution for infusion is produced not in small ampoules, but in 100 ml vials, the concentration of the active substance is 100 or 200 mg. The drug can be used immediately, it does not require further dilution.

Eye drops with ciprofloxacin are intended for the treatment of various infectious eye lesions (conjunctivitis, blepharitis, keratoses and ulcers) caused by sensitive flora. Also, the drug is prescribed to prevent postoperative and post-traumatic complications.

The total volume of the bottle with drops is 5 ml, while 1 ml of the solution contains 3 mg of active ciprofloxacin. With moderately severe symptoms of the disease and in preventive purposes the drug is prescribed 1-2 drops in each eye every four hours. In complicated infections, the frequency of use is increased - the procedure is repeated every two hours.

Ofloxacin or Ciprofloxacin: which is better, other analogues of the drug, restrictions on use

The use of the drug is strictly contraindicated during pregnancy and lactation. In addition, Ciprofloxacin affects the formation of the structure of bone and cartilage tissue, so children under 18 years of age are prescribed it only for strict medical reasons.

Also, contraindications to taking the medicine are hypersensitivity not only to Ciprofloxacin, but also to other medicines from the fluoroquinolone group.

The use of an antibiotic should be carried out under strict medical supervision in violation of the excretory function of the kidneys, severe diseases of the central nervous system. If the use of ciprofloxacin is started after surgery under general anesthesia monitor heart rate and blood pressure.

Unlike other, more secure antibacterial drugs from the class of, for example, penicillins, the risk of adverse reactions during therapy with ciprofloxacin is high.

The patient is warned about such possible side effects:

impaired visual clarity and color perception;
the occurrence of a secondary fungal infection;
digestive disorders, accompanied by vomiting, nausea, heartburn, diarrhea, inflammatory lesions of the intestinal mucosa rarely develop;
dizziness, headache, sleep disorders, anxiety and other psycho-emotional disorders, sometimes convulsions;
hearing loss;
acceleration of heart rate, arrhythmias against the background of low blood pressure;
shortness of breath, impaired lung function;
disorders of the hematopoietic system;
deterioration of kidney and liver function;
rashes, itching, swelling.

Ciprofloxacin is part of many drugs.

So, instead of this medication, the doctor may prescribe the following medications to the patient:

Tsiprolet (solution for infusion, eye drops, tablets of 250 and 500 mg);
Betaciprol (eye drops);
Quintor (tablets and infusion solution);
Tsiprinol (in addition to injection and conventional tablets, there are also capsules with prolonged action);
Ciprodox (tablets with a dosage of 250, 500 and 750 mg).

If we talk about analogues of this antibiotic, we should also mention other antibacterial agents from the group of fluoroquinolones. So, patients are often interested in the doctor, Ofloxacin or Ciprofloxacin, which is better? Or can it be replaced with more modern Norfloxacin or Moxifloxacin?

The fact is that the indications for use for all of these funds are the same. Like Ciprofloxacin, they work well against the main pathogens of cystitis, pneumonia, prostatitis and other infections. But doctors emphasize that the "older" generation of fluoroquinolone, the greater its activity against pathogenic flora. But at the same time, the risk of severe adverse reactions also increases.

Therefore, the question Ofloxacin or Ciprofloxacin, which is better is not entirely correct. An antibiotic should be prescribed solely on the basis of the identified pathogen and the general condition of the patient. In other words, if the doctor sees that Ciprofloxacin will cope with, for example, pyelonephritis, then there is no need to prescribe a stronger, but less safe Norfloxacin or Lomefloxacin.

As for the cost of an antibiotic, it largely depends on the manufacturer and the purity of the substance used to manufacture the drug. So, domestic eye drops with Ciprofloxacin cost from 20 to 30 rubles. A package of 10 tablets with a dosage of 500 mg will cost 120-150 rubles. The cost of one vial of solution for infusion ranges from 25-35 rubles.

Natalia, 50 years old

“Ciprofloxacin was prescribed to treat inflammation of the kidneys. Before that, other, weaker antibiotics were also prescribed, but only this drug helped. The first few days I had to endure droppers, then they switched to pills. I was also pleased with the low price of the medicine. ”

Given the high risk of dangerous adverse reactions, only a doctor should decide whether Levofloxacin or Ciprofloxacin is better. The drugs are quite toxic, so it is additionally recommended to take biochemical and clinical tests blood and urine to prevent possible complications therapy.

Tableted drug Lomefloxacin ® is an effective oral antimicrobial drug.

The drug belongs to fluoroquinolone antibiotics. The main active ingredient is lomefloxacin.

Due to its wide spectrum of action, it is used in various fields of medicine for the treatment of bacterial infections. It helps with all types of inflammation of the urinary tract, respiratory organs, osteomyelitis, skin lesions, tuberculosis. In ophthalmology, eye drops based on lomefloxacin® are used to treat inflammatory processes in the conjunctiva.

The drug belongs to the group of prescription drugs, since, along with efficiency, it is characterized by a rather high toxicity. It is not used to treat children, adolescents and pregnant women, has a number of restrictions on its use and requires strict medical supervision throughout the course of therapy. Why is it impossible to take this drug uncontrollably?

Because Lomefloxacin ® is an antibiotic belonging to the second generation of quinolones (fluoroquinolones). All medications of this group, due to the peculiarities of pharmacokinetics, are able to replace calcium in bone tissue, which leads to a slowdown in the growth of bone cartilage tissue in children (in this regard, the drug is contraindicated in children and pregnant women). There is also a negative effect of drugs on nervous system, ligamentous apparatus and liver. For this reason, the use of tablets on their own, without medical prescription, is unacceptable.

Pharmacological group

According to the generally accepted international classification Lomefloxacin ® belongs to antibacterial agents of the fluoroquinolone class.

Composition of Lomefloxacin ®

The active substance of the drug with this name is the antibiotic of the same name lomefloxacin of the second generation of quinolones (fluorinated). It has a bactericidal effect on most pathogens of bacterial infections, blocking DNA gyrase and preventing further DNA replication. The following types of pathogens are susceptible to the antibiotic:

gram-positive aerobic strains of staphylococci, including golden;
gram-negative aerobes - enterobacter, Citrobacter diversus and freundii, E. coli, Haemophilus influenzae and parainfluenzae, some varieties of Klebsiella, Moraxella catarrhalis, Proteus spp., Morganella morganii, shigella, salmonella, gonococci and others;
atypical microorganisms - ureaplasmas, mycoplasmas, chlamydia, tuberculosis mycobacteria.

Lomefloxacin ® is absorbed from the digestive tract almost completely, and then quickly distributed to the tissues, where its concentration significantly exceeds the plasma concentration. It is noted that the presence of food in the gastrointestinal tract somewhat impairs the absorption of the drug. The drug is excreted mainly by the kidneys, and almost unchanged.

Release form Lomefloxacin ®

Based on this antibiotic, two dosage forms are produced. Patriotic pharmaceutical company Pharmasyntez ® sells enteric-coated tablets through pharmacy chains, where the content of the active substance is 400 mg. They are packaged in cardboard packs of 5 pieces.

Another Russian company, Sintez OJSC, produces eye drops with lomefloxacin hydrochloride in 5-ml dropper bottles under the trade name Lofox. In them, the concentration of the antibiotic is 0.3%.

Recipe for Lomefloxacin ® in Latin

Freely selling antibiotics in pharmacy chains has been prohibited since January last year: organizations face fines and suspension of activities for this. The ban is associated with an increase in the tolerance of infectious agents to drugs. In addition, fluoroquinolones are very dangerous to use for self-medication. To purchase the drug, you will need a prescription filled and certified by a doctor:

Rep.: Tab. Lomefloxacini 0.4

S.t. d. No. 10

D.S. Take one tablet once a day.

Indications for use

A wide antimicrobial spectrum and the effectiveness of the drug allow it to be successfully used in the treatment of infectious and inflammatory processes of various localizations:

(bronchitis, pneumonia, infected bronchiectasis, etc.);
and (pyelonephritis, cystitis, prostatitis, etc.);
, subcutaneous tissue and bone tissue;
tuberculosis (in combination with other medications).

In ophthalmology, lomefloxacin eye drops are prescribed in case of damage to the organs of vision by susceptible microflora (, keratitis).

Contraindications

It is strictly forbidden to use the drug for pregnant women, breastfeeding, as well as children and adolescents under the age of 18 years. The ban is associated with the property of the antibiotic to form insoluble chemical compounds with calcium and slow down the growth of the cartilage tissue skeleton. In addition, you should not take lomefloxacin ® in the presence of hypersensitivity to it, epilepsy, as well as inflammation of the tendons against the background of previous use of fluoroquinolones.

With caution, the drug is prescribed for impaired renal and hepatic function, as well as for atherosclerosis and impaired cerebral circulation.

Dosages and regimens of therapy

Due to the slow elimination from the body, it is enough to take the drug only once a day (only for tuberculosis - twice a day). At what dose and for how long - the doctor decides based on the severity and nature of the disease. On average, treatment regimens are as follows:

Disease	Daily dose, mg	Course of treatment, days
UTI infections, uncomplicated and complicated	400 for uncomplicated course, 800 for complications	3 to 5 for uncomplicated form and up to 10-14 with complicated diseases
Prevention of infections during transurethral interventions	400	A few hours before surgery once
and skin infections	400	5-14
acute and chronic	800	One time per form and 5 days for chronic
urogenital	400-800	up to 28
	from 400 to 800	21-56
acute, bronchopneumonia	400	10
Chronical bronchitis,	400-800	up to 14
	800	to 10

In the treatment of tuberculosis, the drug is taken at 800 mg from two to four weeks (as part of a comprehensive anti-tuberculosis therapy regimen).

Eye drops are applied daily, 2 or 3 times a drop in each eye. The course of treatment averages a week.

Side effects of lomefloxacin ®

Lomefloxacin ® hydrochloride (a chemical form of an antibiotic in preparations), due to toxicity, can provoke the following negative reactions:

disorders of appetite and stool, the development of colitis;
malaise, headaches and eye pain, sleep and consciousness disorders, tremor and convulsive syndrome;
violations of hematopoiesis and heart rhythm, hypotension, progression of ischemia, heart attack;
cough flu-like symptoms, apnea, shortness of breath;
pain in bones, joints, vasculitis;
inflammation and rupture of tendons;
urination disorders, impurities in the urine, intermenstrual bleeding and vaginitis in women, in men - orchitis, epidymitis;
inflammation and rupture of tendons;
rash, photosensitivity, urticaria,.

Eye drops can cause a local burning sensation, and with a long course of treatment - the development of fungal superinfection.

Lomefloxacin ® during pregnancy and breastfeeding

Penetrating through the placenta, the antibiotic prevents the proper development and growth of the fetal bone tissue, causes other mutations. Therefore, the use of the drug Lomefloxacin ® during pregnancy is unacceptable. During lactation, being excreted into milk, the drug causes sensitization in the baby, a violation of the intestinal microflora, candidiasis, and a slowdown in skeletal growth. Therefore, breastfeeding during treatment should be discontinued.

Lomefloxacin ® and alcohol

Such toxic antibiotics as fluoroquinolones should not be combined with the intake of alcoholic beverages. This combination is fraught with serious complications for the liver and kidneys, moreover, against the background of alcohol intoxication, the side effects listed above occur more often. Therefore, the combination of Lomefloxacin ® with alcohol is not only undesirable, but even dangerous for the health and life of the patient. Possible development toxic lesions CNS, drug-induced hepatitis, nephritis, etc.

Analogues of Lomefloxacin ®

On the basis of the active substance with the original name, several preparations similar in composition and action are produced:

Lomflox ®
Xenaquin ®
Lomacin ®
Lofox ®

In addition, the doctor may, as an alternative drug, prescribe another antibiotic from the fluoroquinolone group as indicated.

What is the difference between Lomefloxacin ® and Levofloxacin ®

Represents the third generation of fluoroquinolone antibiotics, so the spectrum of its bactericidal activity is wider. It is more active against gram-positive pathogens, which allows it to be used in more diseases, and optimized pharmacokinetic processes reduce the severity of side effects. In addition, there is dosage form Levofloxacin ® for parenteral administration.

Comparison of Ofloxacin ® and Lomefloxacin ®

Both drugs belong to the second generation of fluoroquinolones, but there is some difference between them. First, it is less toxic. Secondly, a wider spectrum of action determines the use in ENT practice for the treatment of sinusitis, otitis and other infections. Thirdly, in addition to tablets, there is Ofloxacin in the form of ear drops and lyophilisate for intravenous administration.

Antibiotics are widely used in the treatment of diseases of the respiratory system. fluoroquinolone row.

They are highly efficient and have wide spectrum of action. Among the most popular drugs are Ciprofloxacin and Levofloxacin.

Both drugs have been successfully used in the treatment progressive form of tuberculosis. To understand which remedy is better, it is advisable to consider in more detail the features of each of them and compare the effectiveness of the drugs.

Ciprofloxacin

Ciprofloxacin is a classic fluoroquinolone with increased activity against staphylococci and chlamydia. As for diseases that develop as a result of pneumococcal infection entering the body, the drug is ineffective in their regard.

Photo 1. Packing Ciprofloxacin in the form of tablets with a dosage of 250 mg. Producer "OZ GNTsLS".

Ciprofloxacin is prescribed for respiratory tuberculosis. In some cases, complex treatment is carried out with Pyrazinamide, Streptomycin and Isoniazid. It has been clinically proven that monotherapy against tuberculosis is less effective.

Indications for use

Absolute indications for the use of ciprofloxacin are:

acute bronchitis, and exacerbations of the disease in a chronic form;
severe form of tuberculosis;
pulmonary inflammation;
infections that develop as a result of cystic fibrosis;
inflammation of the middle ear - otitis;
sinusitis;
frontitis;
pharyngitis;
tonsillitis;
complicated infections and inflammation of the urinary system;
chlamydia;
gonorrhea;
infectious diseases of the gastrointestinal tract;
infectious skin lesions, burns, ulcers and a number of others.

The drug can be used in the treatment postoperative infectious complications.

Ciprofloxacin has its contraindications and side effects. In most cases, the drug is well tolerated, but against the background of its reception may occur:

allergic reactions;
swelling of the vocal cords;
anorexia;
leukopenia;
agranulocytosis;
thrombocytopenia;
kidney failure;
the occurrence of pain in the abdomen;
stool disorder;
insomnia;
violation of taste perceptions;
headache;
exacerbation of epilepsy.
Contraindications to taking the drug are:
individual intolerance to its individual components;
hypersensitivity to ciprofloxacin.

Medicine not prescribed to women during pregnancy and lactation, as well as children up to 15 years. Antibiotics should be used with caution kidney failure.

Levofloxacin

Levofloxacin - fluoroquinolone third generation. The drug shows high efficiency in relation to pneumococcal, atypical respiratory and gram-negative bacterial infection. Even those pathogens that are fairly resistant to second-generation antibacterial fluoroquinolones are susceptible to Levofloxacin.

Photo 2. Packing of Levofloxacin in the form of tablets with a dosage of 500 mg. Producer "Teva".

The drug is used for pulmonary tuberculosis. The spectrum of its action in this regard is completely identical to Ciprofloxacin. During monotherapy, clinical improvement in patients is observed in about a month.

Indications for use

Indications for the use of Levofloxacin are:

exacerbation of bronchitis;
inflammatory processes in the paranasal sinuses, characterized by a complicated course, for example, sinusitis;
pulmonary inflammation of any form;
inflammatory processes of the infectious nature of the ENT organs;
infections that develop against the background of cystic fibrosis;
inflammation of the genitourinary system: pyelonephritis, inflammation of the prostate, chlamydia;
soft tissue abscesses;
furunculosis.

The active substance of the drug is the chemical component of the same name - levofloxacin. The medicine contains additional components: cellulose, sodium chloride, dihydrate, disodium edetate, titanium dioxide, iron oxide, calcium stearate.

Levofloxacin has several forms of release. Today in domestic pharmacies you can buy drops, tablets and solution for infusion.

Contraindications and side effects

Like any other medicine, the fluoroquinolone Levofloxacin has a number of side effects:

allergy to individual components of the drug;
violation of the functional features of the gastrointestinal tract;
headache accompanied by dizziness;
muscle and joint pain;
feeling tired, drowsiness;
inflammation of the tendons;
acute liver failure;
depression;
rhabdomyolysis;
neutropenia;
hemolytic anemia;
asthenia;
exacerbation of porphyria;
exacerbation of epilepsy;
development of a secondary infection.

Important! Levofloxacin strongly not recommended to be taken without consulting a doctor.

Contraindications to taking the drug are:

a tendency to develop an allergic reaction to individual medicinal components, i.e. individual intolerance;
unhealthy kidneys;
epilepsy;
drug-induced tendon injury associated with treatment with fluoroquinolone antibacterial drugs.

Levofloxacin do not appoint women during pregnancy and while breastfeeding, as well as children and teenagers. Caution should be exercised by patients with renal pathologies and geriatric patients.

In case of drug overdose, symptomatic treatment is expected. Dialysis is not very efficient.

During the course of therapy it is not advisable to drive a car and engage in other activities that require a quick response and increased attention.

Considering the probability photosensitivity It is recommended to stay out of direct sunlight as little as possible.

Which is better: Ciprofloxacin or Levofloxacin? How are antibiotics different?

degree of efficiency;
safety;
price range.

Comparison of drugs: which is more effective

Levofloxacin and Ciprofloxacin have a similar purpose, that is, they spectrum of action is the same but the first drug in terms of effectiveness has a number of advantages.

The active substance of Ciprofloxacin is ciprofloxacin, Levofloxacin contains the main component levofloxacin.

Unlike Ciprofloxacin, the antibacterial effect of Levofloxacin against pneumococcal infection and atypical microorganisms is more pronounced. The drug remains active against gram-negative bacteria.

It is known that some pathogens that are not sensitive to Ciprofloxacin show instability before exposure to Levofloxacin. The latter drug is more active against Pseudomonas (P.) aeruginosa.

The type of bacterium and the degree of its sensitivity is determining factor when choosing a drug.

Photo 3. Packing of Levofloxacin in the form of a solution for intravenous infusion at a dosage of 5 mg / ml. Producer "Belmedpreparaty".

Both fluoroquinolones well tolerated by the body, have excellent oral absorption and are successfully used as an effective anti-tuberculosis agent. Levofloxacin shows greater effectiveness in this regard, because it is used in the form intravenous injections.

The concentration of the active substance in the tablets is less than in the second preparation. Levofloxacin is more commonly prescribed as single drug for monotherapy. Eating does not matter during treatment. Both those and other tablets can be taken both before and after meals.

With regard to adverse reactions, they occur rarely and with the same frequency when taking both Levovloxacin and Ciprofloxacin. Undesirable effects are similar in their manifestations. In patients taking these fluoroquinolones, the following disorders may occur:

Rate this article:

Average rating: 5 out of 5 .
Rated: 2 readers.