Viferon for adults. Viferon candles: instructions for use

Candles Viferon have antiviral and immunostimulating properties. They are prescribed in medical and preventive purposes, age restrictions is not observed. The drug is classified as an immunomodulating agent, which is explained by the presence of recombinant interferon alfa-2b in its composition. After entering the body, it activates the defense mechanism, which leads to a decrease in the likelihood of infection. Viferon is included in the federal standards for the provision medical care, which are guided in the event of the appearance of influenza, SARS, acute respiratory infections and other "cold" pathologies.

Most often, children suffer from infectious diseases. This is due to the fact that their immune system is not fully formed. There are many medicines on the pharmaceutical market that can protect young patients from the negative effects of external environment. The drug Viferon is considered one of the most popular.

It is produced in several forms: ointment, gel, rectal suppositories. The latter are more suitable than others for the treatment and prevention of viral and bacterial pathologies in young children. Viferon is considered a relatively safe drug. When using suppositories in accordance with the instructions for use and the recommendations of the attending physician, the risk of adverse reactions minimal.

Indications

Candles Viferon help adults and children with:

They can help if the patient's history includes cirrhosis of the liver, SARS, secondary diseases provoked by a viral infection, trichomoniasis, vaginosis, ureaplasmosis, viral hepatitis. With the help of Viferon, it is possible to prevent the development of negative consequences during hypothermia or contact with an infected person.

The drug is included in the complex therapy prescribed for premature infants, nursing mothers and women in position (starting from the 14th week of pregnancy). In each of these cases, you should consult with your doctor. Despite the minimum of side effects, Viferon has contraindications.

The combination of this drug with antibacterial and hormonal drugs accompanied by a decrease in their dosage. This does not affect the effectiveness of the therapeutic complex. It should be noted that Viferon is combined with medicines from any pharmacological group. Through the use of these rectal suppositories, you can achieve:

increased production of immunoglobulins;
activation of the synthesis of natural interferon;
accelerate the regeneration of damaged tissues;
stabilization of cell membranes;
relief of foci of inflammation.

The positive effect of suppositories contributes to faster recovery and strengthening immune system patient.

Contraindications

Candles are characterized by the almost complete absence of contraindications. The only limitation is the individual intolerance of the components that make up their composition. We must not forget about caution: the drug is prohibited for use in the first three months of pregnancy. This applies to most medications. During the first trimester, organogenesis occurs, the vital organs of the fetus are formed. The passage of drug therapy is fraught with violations of this process.

The use of Viferon during pregnancy differs in some nuances. The daily dose for a woman expecting a baby is less than the standard. This is due to the fact that during pregnancy, the body of the expectant mother is much more sensitive to medications. If an allergic reaction occurs to Viferon suppositories side effects may appear with greater intensity. You should also beware of people suffering from pathologies of the liver, kidneys, cardiovascular and endocrine systems.

The benefits of the drug

Viferon has a positive effect on the work of macrophage cells. In their functions, the elimination of pathological pathogens. The action of suppositories is not limited to this, they have a pronounced anti-inflammatory effect on the patient's body. Using Viferon, doctors can refuse synthetic emulsifiers, which are often toxic.

Each of the components that make up the drug has an individual therapeutic effect, which ensures a complex effect on the body. The activity of B-lymphocytes, MHC antigens, T-helpers, natural killers is activated. Viferon prevents the reproduction of pathogenic viruses.

Doctors, recommending candles, are guided by the fact that:

They contain antioxidants (vitamins C and E).
The main component (interferon alfa-2b) is not made from blood or blood components.
With their help, you can reduce the risk of toxic poisoning of the body.
They are included in the list of essential medicines.
Their safety profile has been studied in full.

The use of this medication is not complicated by addiction and withdrawal syndrome. The use of Viferon in the form of suppositories avoids an increase in the load on the excretory system and digestive tract. Long-term circulation of interferon alpha-2b in the blood can significantly improve the effect obtained from drug therapy and reduce the likelihood of negative consequences.

Medicinal composition

Candles are white (may have small inclusions of a yellowish tint) and bullet-shaped. Each suppository contains a certain amount of the active ingredient. Manufacturers have provided dosage for patients of different ages. One suppository may contain 3,000,000 IU, 1,000,000 IU, 500,000 IU, 150,000 IU of human recombinant interferon.

In addition to it, the composition of the drug includes the following components:

alpha-tocopherol acetate;
ascorbic acid (vitamin C);
polysorbate;
confectionery fat;
cacao butter.

The last ingredient is necessary for a more convenient introduction. Suppositories are packed in cell packs of 5 or 10 pieces. After the blisters are placed in a cardboard box. Keep the drug at a low temperature, they should not be kept out of the refrigerator. Children are prescribed candles, the dosage of which is 500,000 IU and 150,000 IU. The shelf life of the medicinal product is 2 years. The production date is indicated on the packaging. It is strictly forbidden to use expired candles, they must be disposed of immediately.

Application methods

Candles Viferon are intended for rectal use. The dosage directly depends on the age, weight and chronic pathologies in the patient's history. Gender does not matter. In a woman and a man suffering from the same pathology, the standard daily dose is the same. Also, the doctor must take into account the factor that provoked the malaise.

Viferon is safely prescribed to patients from the following categories:

Newborns younger than six months and premature babies - complex therapy of intrauterine infections, treatment of viral hepatitis and complicated pneumonia.
Children from 6 to 12 months - chronic hepatitis C, D, B. The daily rate is determined based on the results of a blood test.
Babies older than a year - treatment of influenza, parainfluenza, SARS, acute respiratory infections.

With the help of Viferon candles, not only children, but also adults are treated. The drug is taken in full accordance with the treatment regimen prescribed by the doctor. The dose, the order of administration, the duration of therapy depend on the specifics of the disease and the individual characteristics of the patient. During the course of treatment, the patient should regularly undergo control studies. The information obtained after the delivery of laboratory tests is the basis for adjusting the therapeutic regimen.

In the treatment of infectious and inflammatory diseases that have affected the reproductive organs, the patient will have to forget about sexual contacts for a while. Otherwise, there is a high risk of re-infection. If one partner has a urogenital infection, the other must also undergo diagnostic examination. This applies to diseases such as candidiasis, chlamydia, vaginosis, genital herpes and mycoplasmosis. Ignoring unpleasant symptoms is fraught with serious problems in the intimate area. Adults rarely use Viferon to treat colds. Syrups and tablets are more popular. Suppositories in this case are administered to enhance the therapeutic effect.

Candles are inserted into the rectum, following the annotation. First you need to slightly cool your hands, this is necessary to maintain the shape of the rectal suppository. Then the patient should take a comfortable position. If the patient is a child, he is asked to lie on his side and press his knees to his stomach. The patient should not strain too much, subject to all the rules, the discomfort will be minimal and short-lived. The suppository is lubricated with vegetable oil and gently inserted into the anus. After that, the patient should remain in the same position for some time. We must not forget about the rules of hygiene. Wash your hands thoroughly before and after the procedure.

The opinions of parents who used Viferon in the treatment of their children differ. Many of them note such advantages of these candles as compactness, convenience and ease of use, practically complete absence contraindications and adverse reactions. Others leave negative reviews, complaining about the high cost and insufficient positive effect. The latter is most often provoked by mistakes that were made when taking the drug.

Suppositories can be purchased at any stationary pharmacy, and there is no need to provide a prescription from the attending physician. Despite this, before starting therapy, it is necessary to consult a doctor, he will prescribe the most appropriate regimen and dosage.

Side effects

In most cases, Viferon suppositories are well tolerated by patients. Adverse reactions may occur due to an allergic reaction, to its clinical manifestations include the following symptoms:

Itching and burning that occurs when trying to insert a suppository into the anus.
Unpleasant sensations localized in the rectum.
rashes on skin and mucous membranes.

When they appear, you should contact your doctor. It is quite possible that he will revise the treatment regimen: change daily allowance or prescribe a drug that will work without provoking adverse reactions.

In very rare cases Viferon can provoke the appearance of weakness throughout the body, severe headache, dyspeptic disorder, chills, poor appetite, painful sensations in the muscles. These signs are not a reason for symptomatic treatment. They pass without leaving traces in a few days. Parents should not exceed the dose prescribed by the doctor, this is fraught with an overdose. To date, no such cases have been identified, but it's still not worth the risk. It is strictly forbidden to change the order of admission, the duration of the course and the daily rate on your own. Treatment should be under the supervision of a physician.

Candles are allowed to be combined with many medicines, the main thing is not to neglect the manufacturer's instructions and carefully observe the body's reaction to the medication. During treatment, it is necessary to monitor the work of the gastrointestinal tract. Before using the suppository, it is recommended to carry out cleaning procedures.

If a sick person has an allergic reaction to Viferon, the drug is replaced with analogues. They are structural and functional. The list of the most effective contains the following drugs:

Laferobion;
Grippferon;
Kipferon;
Interferon;
Alfarekin;
Laferon;
Lipoferon.

Some of them, like Viferon, are allowed to be included in the therapeutic regimen for infants (Kipferon, Grippferon).

Candles Viferon is a universal drug that is allowed to be used to treat infants and pregnant women. Its effectiveness has been clinically proven, which is confirmed by relevant documents. Viferon is recognized as a medicine that can relieve the symptoms of many inflammatory and infectious pathologies. It also has antioxidant properties.

Viferon is characterized by a unique mechanism of action. The drug stimulates the production of its own protective molecules. They fight pathogens from the inside, blocking their reproduction. At the same time, a restructuring occurs in healthy cells of the body, as a result of which the virus or bacterium can no longer penetrate into them. This is interference, it underlies the preventive effect that occurs when using all forms of this drug. The therapeutic effect of Viferon is manifested both before and after infection. Having passed the prevention, you can not be afraid of infectious diseases and complications.

According to doctors, the greatest therapeutic effect can be achieved using Viferon rectal suppositories in the general therapeutic regimen. The drug is often prescribed for preventive purposes, for example, to strengthen the immune defenses in the fall or spring. It is allowed to be included in the medical complex at any stage of an acute infectious disease.

Among the huge number of medicines actively advertised by manufacturers and recommended by doctors as a panacea for various infectious diseases, a series of drugs under the Viferon brand stands in a special place.

First of all, because this medicine is widely used in treatment regimens for severe septic conditions in newborns, including premature ones.

It is also successfully used in gynecology in the treatment of diseases of the female genital area caused by fungal flora, protozoa or atypical bacteria that are resistant to most of the antimicrobial agents.

In addition, the medicine is very effective in the treatment of herpes and viral hepatitis.

With all this, reviews about Viferon are quite contradictory. And even having collected all the information available on the Internet, it is not only difficult enough, but almost impossible to understand how much the drug is necessary for you.

Neither numerous figures, nor mysterious medical terms, nor unprofessional laudatory odes or the same unprofessional criticism, do not allow a person who encounters this drug for the first time to decide what exactly the doctor has prescribed for him: an absolutely harmless and super-effective medicine or an unintelligible complex, from which it is difficult to expect serious, and, most importantly, quick, benefits.

In search of truth

Mothers of newborn babies and pregnant women are especially zealous in search of unofficial information about the drug. And this is not surprising: after all, doctors usually use Viferon suppositories in the treatment of infants suffering from respiratory or herpes infections, atypical forms of pneumonia and other diseases that are extremely dangerous for the body of a child in the first days of life.

In obstetric and gynecological practice, Viferon is also used very often, and not only for vaginal infections of a fungal, bacterial or viral nature, but also for influenza, acute respiratory infections and other infectious diseases capable of causing significant harm to the developing fetus.

It should be noted that the active use in obstetrics, neonatology and pediatrics is in itself the best evidence of the negligible toxicity of the drug and the absence of any serious reactions to its action.

However, it must be remembered that even the most harmless medicine is, nevertheless, a medicine. And it should be used exclusively according to indications, and not because the drug helped (or did not help) a friend, colleague.

Let's figure out what, how and why this group of drugs treats, in which cases the use of ointment, gel and suppositories is indicated, when treatment with Viferon can help without the additional use of other drugs, and when you should not rely on the omnipotence of the drug.

Let's determine what side effects may occur when using the drug in one form or another, and why you need to carefully study this section of the instructions before buying and using Viferon.

Composition and dosage forms

Preparations from the Viferon series are available in the form ointments, gels and rectal suppositories. If until now you have not had to use such a dosage form as suppositories, and you are confused by the incomprehensible word “rectal”, do not attribute this term to some unknown properties of the medicine.

They are called rectal suppositories due to their method of application: the suppository is released from plastic packaging and applied rectally, i.e. is laid in the rectum (in Latin - rectum). Here, under the influence of the temperature of the human body, the waxy base-forming substance melts, and the drug base is absorbed into the mucous membrane and enters the bloodstream.

The main active ingredient of each of the dosage forms of Viferon is interferon human recombinant alpha-2. Synthetic protein obtained in the laboratory using genetic engineering. It is completely identical to interferon produced in human body in response to exposure to harmful viral or bacterial microorganisms, and protecting tissue cells from the destructive effects of infection.

Once in the focus of infection, "foreign" interferon begins to work "in unison" with the person's own interferons, while simultaneously stimulating the production of the latter.

Interferon alpha-2 has the highest activity against viruses. Moreover, unlike many antiviral drugs that act very specifically, interferon is equally effective in influenza, hepatitis, herpes and other viral infections.

The second area where interferon has managed to prove itself from the very best sides is the treatment of diseases caused by atypical and resistant to antimicrobial bacteria or protozoa. Preparations based on a miracle protein are used for ureaplasmosis, chlamydia, gardnerellosis and trichomoniasis.

In addition, interferon shows very good results in the treatment of fungal infections - candidiasis and mycoplasmosis.

In general, on the basis of interferon, many effective drugs, such as Kagocel, Arbidol, Anaferon, etc.

However, you need to know that in each drug from the Viferon series of drugs, interferon has “faithful squires” that complement and enhance its action, as well as remove the unwanted effects that it can cause, first of all, in people with increased allergies.

Viferon ointment contains tocopherol acetate (vitamin E), the composition of the gel to help interferon, along with vitamin E, comes with an alcohol solution of methionine, benzoic and citric acid, as well as no less powerful immunomodulator than interferon - human serum albumin.

The polyvalent powerful medicinal effect of candles is explained by the presence in them of the most powerful antioxidant tandem: vitamin E and ascorbic acid.

In addition to active ingredients, each dosage form includes auxiliary and formative additives, a detailed list of which you will find in the annotation. By the way, before using the medicine, its full composition is recommended to be carefully studied. First of all, it concerns allergy sufferers. After all, if you or your child cannot tolerate, for example, cocoa butter, which is part of the candles, then the use of the drug in this form is contraindicated for you.

Why is it not available in tablets and injections

This is explained quite simply. Getting into gastrointestinal tract, any medicine is exposed to the action of gastric juice, bile, pancreatic secretion and the numerous enzymes contained in them (and not only in them) involved in the digestive processes.

These enzymes actively decompose protein molecules that enter our body with food. And since we already know that the main active ingredient of Viferon - interferon - is nothing more than a protein, it is not surprising that the medicine taken orally will simply be ineffective.

As for injections, everything is much more serious here: there are many interferon-based drugs that are used by doctors as immunomodulating auxiliaries in the treatment of a wide variety of conditions, including tumor processes.

However, the introduction of these drugs directly into the blood can cause very serious reactions from the most various bodies and systems.

To such medicinal substances, for example, includes an interferon-containing injection drug called Feron. Some patients in the reviews tend to combine these two drugs, considering Feron to be an analogue of Viferon and thinking that they differ very slightly, mainly by the country of production (Feron is produced in Japan).

Many also mistakenly consider Viferon and Feron to be analogues, focusing on the name of the Russian pharmaceutical company that produces Viferon - Feron.

However, all this is not so. As mentioned above, the active ingredient in Viferon is interferon alpha-2, while in Feron a protein with a different structure, called interferon beta-1b, “works”.

Therefore, they are not analogues, these are 2 different drugs, of which Feron is more aggressive and is used to treat cancer and other conditions in which the harm from possible adverse reactions is lower than the benefits.

While developing Viferon, Feron pharmacologists set themselves a completely different goal: to create a series of safe drugs for the treatment of viral and other infections, including in infants and pregnant women.

Therefore, it makes no sense to look for Viferon in pharmacies in the form of injections or tablets: the drug is produced exclusively in the three dosage forms described above.

Application of ointment, gel and suppositories Viferon

Three dosage forms, and, in fact, three quite different drugs called Viferon are used in various therapy regimens.

Suppositories are most widely used, indications for the use of Viferon gel are quite limited, and the ointment is used exclusively for local treatment skin rashes with herpes. Such rashes are characteristic of herpes zoster, genital herpes, otitis externa of a herpes nature and the "common cold" - rashes on the lips.

With herpes zoster, herpetic eruptions are most abundant in the lower back, lower back and abdomen (hence the name of the disease). Genital herpes, as the name of the disease implies, is localized on the mucous membranes and skin of the genitals, and with otitis externa, a herpes infection affects auricle.

If genital and "cold" herpes cause itching, discomfort and general malaise, then a rash with shingles and otitis media, among other things, is accompanied by severe pain, which, along with fever and other symptoms of the disease, quickly pass when using Viferon gel or ointment. At the same time, the ointment has a milder effect, and the gel is more effective.

In addition to the treatment of herpetic rash, the gel is used in the complex therapy of laryngotracheitis of a viral and bacterial nature, accompanied by severe catarrhal symptoms (swelling and redness of the mucosa), spasm and persistent cough.

Such tracheobronchitis is very difficult to treat according to the usual scheme, but the use of Viferon gel in most cases allows you to achieve quick and lasting relief.

This happens, among other things, because the gel has one extremely useful property: when applied to any part of the body, including the tonsils, the drug creates a film on the treated surface, which remains there for a sufficiently long period of time.

It goes without saying that all this time interferon and albumin are actively "working" for the benefit of our body. Unfortunately, it is the substances involved in the formation of the film that most often cause gel intolerance. Ointment causes allergies in extremely rare cases.

The use of Viferon gel in the treatment of viral diseases of various localization is often combined with the simultaneous administration of suppositories. Such a complex effect brings very good results.

It should be noted that Viferon in candles is used so widely that it simply will not work to tell about it in a nutshell. Therefore, we will devote the entire next section to this unique dosage form, which helps very well in the fight against infections of various kinds and manifestations.

Candles Viferon is a complex preparation containing interferon human recombinant alpha-2, ascorbic acid and alpha-tocopherol acetate. It has antiviral, immunomodulatory and antiproliferative effects.

Each suppository contains an active ingredient - human recombinant interferon 150,000 IU, 500,000 IU, 1,000,000 IU or 3,000,000 IU, as well as auxiliary components: alpha-tocopherol acetate, polysorbate, cocoa butter, fat, ascorbic acid.

The main active ingredient in suppositories is human interferon, which has a powerful immunostimulating and antiviral effect.

Interferon, when it enters the general bloodstream, contributes to the activation of protective forces and the recognition of pathological pathogens by macrophage cells. Does not have direct antiviral action, but causes changes in the cell affected by the virus and in the surrounding cells that prevent the reproduction of the virus. Promotes the release of viral particles from the affected cell, their inactivation by other immune agents.

Ascorbic acid and tocopherol acetate are powerful antioxidants and membrane stabilizing components. In combination with them, the effectiveness of interferon increases by 10-15 times.

In addition, their presence enhances the immunomodulatory effect of interferon on T- and B-lymphocytes, leads to the normalization of the content of immunoglobulin E, and reduces the manifestation of side effects.

Cocoa butter contains phospholipids, which make it possible not to use synthetic toxic emulsifiers in production, and the presence of polyunsaturated fatty acids facilitates the administration and dissolution of the drug.

Indications for use

What helps Viferon? According to the instructions, the drug is prescribed in the following cases:

acute respiratory viral infections, including influenza, incl. complicated bacterial infection, pneumonia (bacterial, viral, chlamydial) in children and adults as part of complex therapy;
infectious and inflammatory diseases of newborns, incl. premature, such as meningitis (bacterial, viral), sepsis, intrauterine infection (chlamydia, herpes, cytomegalovirus infection, enterovirus infection, candidiasis, incl. visceral, mycoplasmosis), as part of complex therapy;
chronic viral hepatitis B, C, D in children and adults as part of complex therapy, incl. in combination with the use of plasmapheresis and hemosorption in chronic viral hepatitis of severe activity, complicated by cirrhosis of the liver;
infectious and inflammatory diseases of the urogenital tract (chlamydia, cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis) in adults as part of complex therapy;
primary or recurrent herpetic infection of the skin and mucous membranes, localized form, mild and moderate course, incl. urogenital form in adults.

Instructions for use of Viferon suppositories, dosages for children and adults

Suppositories (candles) are intended for rectal use. The instruction recommends the following dosages of Viferon suppositories for children and adults for complex treatment SARS:

Premature newborns with a gestational age of up to 34 weeks - daily, 1 suppository with a dosage of 150,000 IU \ 3 times a day with an interval of 8 hours for 5 days (according to indications, treatment can be continued with a break of 5 days);
Children under 7 years old, including newborns and premature babies with a gestational age of 34 weeks - daily, 1 piece 150,000 IU \ 2 times a day with an interval of 12 hours for 5 days (according to indications, treatment can be continued with a break of 5 days);
Adults and children from 7 years old - daily for 5 days (according to indications, possibly longer) \ 2 times a day with a break of 12 hours, 1 suppository of 500,000 IU.

Infectious and inflammatory diseases of newborns, incl. premature infants, such as meningitis (bacterial, viral), sepsis, intrauterine infection (chlamydia, herpes, cytomegalovirus infection, enterovirus infection, candidiasis, including visceral, mycoplasmosis) as part of complex therapy:

The recommended dose for newborns, incl. premature babies with a gestational age of more than 34 weeks - daily 1 suppository Viferon 150,000 IU \ 2 times a day after 12 hours. The course of treatment is 5 days.
Premature newborns with a gestational age of less than 34 weeks are prescribed Viferon 150,000 IU daily, 1 suppository 3 times a day after 8 hours. The course of treatment is 5 days.

The number of courses recommended by the instruction for various infectious and inflammatory diseases: sepsis - 2-3 courses, meningitis - 1-2 courses, herpes infection - 2 courses, enterovirus infection - 1-2 courses, cytomegalovirus infection - 2-3 courses, mycoplasmosis, candidiasis , incl. visceral - 2-3 courses. The break between courses is 5 days. According to clinical indications, therapy can be continued.

As part of complex therapy for various urogenital infections (chlamydia, ureaplasmosis, trichomoniasis, hardrenellosis, mycoplasmosis, vaginal candidiasis, bacterial vaginosis) - 1 suppository rectally \ 2 times a day with a dosage of 500,000 IU or 1 time per day with a dosage of 1,000,000 IU. According to the instructions for use, the duration of the course of treatment with Viferon suppositories is at least 5 days. If necessary, you can undergo a second course of therapy with an interval of 5 days. During the treatment of urogenital infections, sexual intercourse should be avoided.

Chronic viral hepatitis of severe activity and liver cirrhosis, before hemosorption and / or plasmapheresis:

Recommended for children under 7 daily use Viferon 150,000 IU;
Children over 7 years old - 500,000 IU 2 times a day with a break of 12 hours for 14 days.

Recurrent or primary herpetic infection of the skin and mucous membranes, localized form (moderate and mild course): the recommended single dose for adults for 10 days is 1,000,000 IU, for pregnant women from the 2nd trimester - 500,000 IU. The drug is used daily 2 times a day (every 12 hours).

In the presence of clinical indications, therapy can be continued. In the future, Viferon suppositories can be used for pregnant women according to the treatment regimen for infectious and inflammatory diseases of the urogenital tract.

Side effects

The instruction warns of the possibility of developing the following side effects when prescribing Viferon suppositories:

in rare cases - allergic reactions (skin rashes, itching).

These phenomena are reversible and disappear 72 hours after discontinuation of the drug.

Contraindications

Viferon is contraindicated in the following cases:

hypersensitivity to any of the components of the drug.

The drug is approved for use from the 14th week of pregnancy.

It has no restrictions for use during lactation.

Overdose

There are no data on cases of overdose.

Viferon analogues, price in pharmacies

If necessary, Viferon candles can be replaced with an analog according to therapeutic effect are the drugs:

Infagel,
Vitaferon,
Laferon,
Laferobion,
Grippferon.

When choosing analogues, it is important to understand that the instructions for using Viferon suppositories, price and reviews, for drugs similar action do not apply. It is important to consult a doctor and not to make an independent replacement of the drug.

Price in pharmacies in Moscow and Russia: Viferon candles 150 thousand IU 10 pcs. - from 278 rubles, rectal suppositories 500 thousand IU 10 pcs. - from 379 rubles, according to 682 pharmacies.

Store in a dark, dry place out of the reach of children at a temperature of 2-8 °C. The shelf life of suppositories is 2 years.

Terms of dispensing from pharmacies - without a prescription.

Release form: Solid dosage forms. Suppositories are rectal.

General characteristics. Composition:

Active substance: 150,000 IU, 500,000 IU, 1,000,000 IU, or 3,000,000 IU human recombinant interferon alfa-2b.

Excipients: alpha-tocopherol acetate, ascorbic acid, sodium ascorbate, disodium edetate dihydrate, polysorbate-80, cocoa butter base and confectionery fat.

Pharmacological properties:

Pharmacodynamics. Interferon alpha-2b human recombinant has immunomodulatory, antiviral, antiproliferative properties. The immunomodulatory properties of interferon, such as increased phagocytic activity of macrophages, increased specific cytotoxicity of lymphocytes to target cells, determine its mediated antibacterial activity.

In the presence of ascorbic acid and alpha-tocopherol acetate, the specific antiviral activity of interferon increases, its immunomodulatory effect increases, which makes it possible to increase the efficiency of the body's own immune response to pathogenic microorganisms. When using the drug, the level of class A secretory immunoglobulins increases, the level of immunoglobulin E normalizes, and the functioning of the endogenous interferon system is restored. Ascorbic acid and alpha-tocopherol acetate, being highly active antioxidants, have anti-inflammatory, membrane-stabilizing, and regenerating properties. It has been established that when using Viferon, there are no side effects that occur with the parenteral administration of interferon preparations, no antibodies are formed that neutralize the antiviral activity of interferon.

The use of the drug allows to reduce the therapeutic doses of antibacterial and hormonal drugs, as well as reduce the toxic effects of this therapy.

Indications for use:

- acute respiratory viral infections, including those complicated by a bacterial infection (bacterial, viral, chlamydial) in children and adults as part of complex therapy;
- infectious and inflammatory diseases of newborns, including premature babies: (bacterial, viral), (chlamydia, herpes, candidiasis, including visceral, mycoplasmosis) as part of complex therapy;
- chronic viral hepatitis B, C, D in children and adults as part of complex therapy, including in combination with the use and in chronic viral hepatitis of severe activity, complicated by cirrhosis of the liver;
- infectious and inflammatory diseases of the urogenital tract (chlamydia, cytomegalovirus infection, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis) in adults as part of complex therapy;
- primary or recurrent herpetic infection of the skin and mucous membranes, localized form, mild and moderate course, including the urogenital form in adults.

Important! Get to know the treatment

Dosage and administration:

The drug is used rectally. 1 suppository contains human recombinant interferon alfa-2b as an active substance in the indicated dosages (150,000 IU, 500,000 IU, 1,000,000 IU, 3,000,000 IU).

Acute respiratory viral infections, including influenza, including those complicated by a bacterial infection, pneumonia (bacterial, viral, chlamydial) in children and adults as part of complex therapy.Recommended dose for adults, including pregnant women and children over 7 years of age VIFERON® 500,000 IU 1 suppository 2 times a day every 12 hours daily for 5 days. According to clinical indications, therapy can be continued.

Children under 7 years of age, including newborns and premature babies with a gestational age of more than 34 weeks, are recommended to use the drugVIFERON® 150,000 IU 1 suppository 2 times a day every 12 hours daily for 5 days. According to clinical indications, therapy can be continued. The break between courses is 5 days.

For premature newborns with a gestational age of less than 34 weeks, the use of VIFERON® 150,000 IU is recommended.1 suppository 3 times a day after 8 hours daily for 5 days.According to clinical indications, therapy can be continued. The break between courses is 5 days.

Infectious and inflammatory diseases of newborns, including premature infants: meningitis (bacterial, viral), sepsis, intrauterine infection (chlamydia, herpes, cytomegalovirus infection, enterovirus infection, candidiasis, including visceral, mycoplasmosis) as part of complex therapy.The recommended dose for newborns, including premature babies with a gestational age of more than 34 weeks, is VIFERON® 150,000 IU daily, 1 suppository 2 times a day after 12 hours. The course of treatment is 5 days.

Premature newborns with a gestational age of less than 34 weeks are recommended to use the drug VIFERON® 150,000 IU daily, 1 suppository 3 times a day after 8 hours. The course of treatment is 5 days.

The recommended number of courses for various infectious and inflammatory diseases: sepsis - 2-3 courses, meningitis - 1-2 courses, herpes infection - 2 courses, enterovirus infection - 1-2 courses, cytomegalovirus infection - 2-3 courses, mycoplasmosis, candidiasis, including visceral — 2-3 courses. The break between courses is 5 days. According to clinical indications, therapy can be continued.

Chronic viral hepatitis B, C, D in children and adults as part of complex therapy, including in combination with the use of plasmapheresis and hemosorption in chronic viral hepatitis of severe activity, complicated by liver cirrhosis.The recommended dose for adults is VIFERON® 3,000,000 IU, 1 suppository 2 times a day every 12 hours daily for 10 days, then three times a week every other day for 6-12 months. The duration of treatment is determined by clinical efficacy and laboratory parameters.

Children aged 1 to 7 years are recommended 3,000,000 IU per 1 m2 of body surface area per day.

The drug is used 2 times a day after 12 hours for the first 10 days daily, then three times a week every other day for 6-12 months. The duration of treatment is determined by clinical efficacy and laboratory parameters.

The calculation of the daily dose of the drug for each patient is made by multiplying the recommended dose for a given age by the body surface area calculated from the nomogram to calculate the body surface area by height and weight according to Harford, Terry and Rourke. The calculation of a single dose is carried out by dividing the calculated daily dose by 2 injections, the resulting value is rounded up to the suppository dosage up.

In chronic viral hepatitis of severe activity and liver cirrhosis, before plasmapheresis and / or hemosorption, it is recommended to use VIFERON® 150,000 IU for children under 7 years of age, VIFERON® 500,000 IU for children over 7 years of age, 1 suppository 2 times a day after 12 hours daily within 14 days.

Infectious and inflammatory diseases of the urogenital tract (chlamydia, cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis) in adults, including pregnant women as part of complex therapy.The recommended dose for adults is VIFERON® 500,000 IU, 1 suppository 2 times a day every 12 hours daily for 5-10 days. According to clinical indications, therapy can be continued.

2 times a day after 12 hours daily for 10 days, then for 9 days 3 times with an interval of 3 days (on the fourth day) 1 suppository 2 times a day after 12 hours. Then every 4 weeks until delivery VIFERON® 150,000 IU1 suppository 2 times a day after 12 hours daily for 5 days.

If necessary, it is indicated before delivery (from 38 weeks of gestation) the use of the drug VIFERON® 500,000 IU, 1 suppository 2 times a day after 12 hours daily for 10 days.

Primary or recurrent herpetic infection of the skin and mucous membranes, localized form, mild and moderate course, including the urogenital form in adults, including pregnant women.The recommended dose for adults is VIFERON® 1,000,000 IU, 1 suppository 2 times a day every 12 hours every day for 10 days or more in case of recurrent infection. According to clinical indications, therapy can be continued. It is recommended to start treatment immediately when the first signs of skin and mucous membrane lesions (itching, burning, redness) appear.

In the treatment of recurrent herpes, it is desirable to begin treatment in the prodromal period or at the very beginning of the manifestation of signs of relapse.

Pregnant women from the II trimester of pregnancy (starting from the 14th week of gestation) are recommended to use the drug VIFERON® 500,000 IU, 1 suppository2 times a day after 12 hours daily for 10 days, then for 9 days 3 times with an interval of 3 days (on the fourth day) 1 suppository 2 times a day after 12 hours. Then every 4 weeks until delivery VIFERON® 150000 IU 1 suppository 2 times a day after 12 hours daily for 5 days. If necessary, it is indicated before delivery (from 38 weeks of gestation) the use of the drug VIFERON® 500,000 IU, 1 suppository 2 times a day after 12 hours daily for 10 days.

Dosing regimen	Week of gestation*	Application scheme
From the 14th week of gestation VIFERON® 500,000 IU 1 suppository 2 times a day for 10 days. Then VIFERON® 500,000 IU 1 suppository 2 times a day after 3 days, 3 times for 9 days.
Step 1. C + C (morning/evening) VIFERON® 500,000 IU



Step 2 C + C (morning/evening) VIFERON® 150,000 IU	20, 24 28, 32 36, 40
From 38 weeks of gestation to delivery VIFERON® 500,000 IU 1 suppository 2 times a day for 10 days.
C + C (morning/evening) VIFERON® 500,000 IU

Application Features:

Impact on ability to drive vehicles and engage in other activities. Not installed.

Use during pregnancy and during breastfeeding: The drug is approved for use from the 14th week of pregnancy. Has no restrictions for use during breastfeeding.

Side effects:

In rare cases, the development of allergic reactions (skin rashes, itching) is possible. These phenomena are reversible and disappear 72 hours after discontinuation of the drug.

Interaction with other drugs:

VIFERON®, rectal suppositories, is compatible and goes well with all medicines used in the treatment of the above diseases (antibiotics, chemotherapy drugs, glucocorticosteroids).

Contraindications:

Hypersensitivity to any of the components of the drug.

Overdose:

Not installed.

Storage conditions:

At a temperature of 2 to 8 ° C, in a place protected from light. Keep out of the reach of children. Shelf life - 2 years. Do not use the drug after the expiration date.

Leave conditions:

Without recipe

Package:

Rectal suppositories 150000 IU, 500000 IU, 1000000 IU, 3000000 IU. 5 or 10 suppositories in PVC/PVC blisters. 1 blister pack of 10 suppositories or 2 blister packs of 5 suppositories with instructions for use in a cardboard pack.