Flemoxin Solutab: instructions for use for adults and children. Flemoxin solutab - instructions for use for children and adults Flemoxin 500 from what

Dispersible tablets from white to light yellow, oval, with the company logo and the digital designation "231" on one side and a line dividing the tablet in half on the other side.

Excipients: dispersible cellulose - 4.3 mg, microcrystalline cellulose - 6.3 mg, crospovidone - 6.3 mg, vanillin - 0.13 mg, tangerine flavor - 1.1 mg, lemon flavor - 1.4 mg, saccharin - 1.6 mg, magnesium stearate - 0.76 mg.

Dispersible tablets from white to light yellow, oval, with the company logo and the digital designation "232" on one side and the line dividing the tablet in half on the other side.

Excipients: dispersible cellulose - 8.7 mg, microcrystalline cellulose - 12.6 mg, crospovidone - 12.6 mg, vanillin - 0.26 mg, tangerine flavor - 2.3 mg, lemon flavor - 2.8 mg, saccharin - 3.3 mg, magnesium stearate - 1.5 mg.

5 pieces. - blisters (4) - packs of cardboard.

Dispersible tablets from white to light yellow, oval, with the logo of the company and the digital designation "234" on one side and the line dividing the tablet in half on the other side.

Excipients: dispersible cellulose - 17.4 mg, microcrystalline cellulose - 25.2 mg, crospovidone - 25.2 mg, vanillin - 0.5 mg, tangerine flavor - 4.5 mg, lemon flavor - 5.6 mg, saccharin - 6.6 mg, magnesium stearate - 3 mg.

5 pieces. - blisters (4) - packs of cardboard.

Dispersible tablets from white to light yellow in color, oval, with the company logo and the digital designation "236" on one side and the line dividing the tablet in half on the other side.

Excipients: dispersible cellulose - 34.8 mg, microcrystalline cellulose - 50.5 mg, crospovidone - 50.4 mg, vanillin - 1 mg, tangerine flavor - 9.1 mg, lemon flavor - 11.1 mg, saccharin - 13.1 mg, magnesium stearate - 6 mg.

5 pieces. - blisters (4) - packs of cardboard.

Clinical and pharmacological group

Antibiotic of the penicillin group of a wide spectrum of action, destroyed by penicillinase

pharmachologic effect

Bactericidal acid-resistant broad-spectrum antibiotic from the group of semi-synthetic penicillins. Violates the synthesis of peptidoglycan (supporting polymer of the cell wall) during the period of division and growth, causes lysis of bacteria.

Active against gram-positive and gram-negative microorganisms: Streptococcus pyogenes, Streptococcus pneumoniae, Clostridium tetani, Clostridium welchii, Neisseria gonorrhoeae, Neisseria meningitidis, Staphylococcus aureus (non-β-lactamase producing), Bacillus anthracis, Listeria monocytogenes, Helicobacter pylori.

Less active towards Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Salmonella typhi, Shigella sonnei, Vibrio cholerae.

Not active for microorganisms producing β-lactamase, Pseudomonas spp., Proteus spp. (indole-positive strains), Serratia spp., Enterobacter spp.

Penicillinase-producing strains are resistant to the action of amoxicillin.

Pharmacokinetics

Suction

After oral administration, amoxicillin is absorbed quickly and almost completely (93%), and is not destroyed in the acidic environment of the stomach. Eating has practically no effect on the absorption of the drug. After ingestion of 500 mg of amoxicillin, C max of the active substance, which is 5 μg / ml, is observed in blood plasma after 2 hours. With an increase or decrease in the dose of the drug by 2 times, C max in blood plasma also changes 2 times.

Distribution

Plasma protein binding is 17%. Amoxicillin penetrates the mucous membranes, bone tissue, intraocular fluid and sputum in therapeutically effective concentrations. The concentration of amoxicillin in bile exceeds its concentration in blood plasma by 2-4 times. In the amniotic fluid and umbilical vessels, the concentration of amoxicillin is 25-30% of its level in the blood plasma of a pregnant woman. Amoxicillin does not penetrate well through the BBB; however, in inflammation of the meninges, the concentration in the cerebrospinal fluid is about 20% of the concentration in the blood plasma.

A small amount is excreted in breast milk.

Metabolism

Amoxicillin is partially metabolized in the liver, most of its metabolites are not microbiologically active.

breeding

Amoxicillin is excreted by 50-70% by the kidneys unchanged (by tubular excretion - 80% and glomerular filtration - 20%), by the liver - 10-20%.

In the absence of impaired renal function, T 1/2 of amoxicillin is 1-1.5 hours. In premature babies, newborns and children under 6 months - 3-4 hours.

Pharmacokinetics in special clinical cases

T 1/2 amoxicillin does not change in violation of liver function.

In case of impaired renal function (CC ≤ 15 ml / min), T 1/2 amoxicillin increases and reaches 8.5 hours with anuria.

Amoxicillin is removed from the body during hemodialysis.

Indications for the use of the drug

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

- infections of the respiratory system;

- infections of the genitourinary system;

- infections of the digestive tract;

- Infections of the skin and soft tissues.

Dosing regimen

The drug is taken orally. The drug is prescribed before, during or after a meal. The tablet can be swallowed whole, divided into parts or chewed with a glass of water, and can also be diluted in water to form a syrup (in 20 ml) or suspension (in 100 ml) with a pleasant fruity taste.

The dosage regimen is set individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.

When infectious and inflammatory diseases of the lungs and moderate it is recommended to use the drug according to the following scheme: adults And children over 10 years old appoint 500-750 mg 2 times / day or 375-500 mg 3 times / day; children aged 3 to 10 years appoint 375 mg 2 times / day or 250 mg 3 times / day; children aged 1 to 3 years appoint 250 mg 2 times / day or 125 mg 3 times / day.

The daily dose of the drug for children ( including children under 1 year old) is 30-60 mg / kg / day, divided into 2-3 doses.

At treatment of severe infections and hard-to-reach foci of infection(for example, sharp otitis media) three doses are recommended.

At chronic diseases, recurrent infections, infections severe course adults appoint 0.75-1 g 3 times / day; children- 60 mg / kg / day, divided into 3 doses.

At acute uncomplicated gonorrhea prescribe 3 g of the drug in 1 dose in combination with 1 g of probenecid.

at QC≤10 ml/min

When lung infections and moderate severity the drug is taken within 5-7 days. However, for infections caused by Streptococcus pyogenes, the duration of treatment should be at least 10 days.

The drug should be continued for 48 hours after the disappearance of the symptoms of the disease.

Side effect

From the digestive system: rarely - a change in taste, nausea, vomiting, diarrhea, dysbacteriosis, stomatitis, glossitis; in some cases - a moderate increase in the activity of hepatic transaminases, cholestatic jaundice, hepatic cholestasis, acute cytolytic hepatitis, pseudomembranous and hemorrhagic colitis.

From the urinary system: development of interstitial nephritis, crystalluria.

From the hematopoietic system: leukopenia, neutropenia, thrombocytopenic purpura, eosinophilia, thrombocytopenia, agranulocytosis, hemolytic anemia.

From the side nervous system: agitation, anxiety, insomnia, ataxia, confusion, behavioral changes, depression, peripheral neuropathy, headache, dizziness, epileptic convulsions.

Allergic reactions: skin reactions, mainly in the form of a specific maculopapular rash, urticaria, skin flushing, erythematous rashes, rhinitis, conjunctivitis, erythema multiforme exudative (Stevens-Johnson syndrome), fever, arthralgia, eosinophilia, exfoliative dermatitis, reactions similar to serum disease, toxic epidermal necrolysis, allergic vasculitis, acute generalized exanthematous pustulosis; in some cases - anaphylactic shock, angioedema.

Others: difficulty breathing, vaginal candidiasis, superinfection (especially in patients with chronic diseases or reduced body resistance).

Contraindications to the use of the drug

- hypersensitivity to the components of the drug;

- hypersensitivity to other beta-lactam antibiotics, incl. to other penicillins, cephalosporins, carbapenems.

FROM caution the drug should be used for polyvalent hypersensitivity to xenobiotics, infectious mononucleosis, lymphocytic leukemia, a history of gastrointestinal diseases (especially with colitis associated with the use of antibiotics), kidney failure, during pregnancy and lactation, allergic reactions (including history).

The use of the drug during pregnancy and lactation

The use of the drug Flemoxin Solutab ® during pregnancy and lactation is possible if the expected benefit of therapy for the mother outweighs the risk of side effects in the fetus and infant.

In small amounts, amoxicillin is excreted in breast milk, which can lead to the development of sensitization phenomena in an infant.

Application for violations of kidney function

Patients with impaired renal function at QC≤10ml/min the dose of the drug is reduced by 15-50%.

special instructions

The drug should be prescribed to patients with infectious mononucleosis and lymphocytic leukemia with caution, since there is a high probability of non-allergic exanthema.

The presence of erythroderma in history is not a contraindication for the appointment of the drug Flemoxin Solutab ® .

Cross-resistance with penicillins and cephalosporins is possible.

The appearance of severe diarrhea, characteristic of pseudomembranous colitis, is an indication for discontinuation of the drug.

During the course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

It is possible to develop superinfection due to the growth of microflora insensitive to the drug, which requires an appropriate change. antibiotic therapy.

At treatment of mild diarrhea against the background of course treatment, antidiarrheal drugs that reduce intestinal motility should be avoided; kaolin- or attapulgite-containing antidiarrheals can be used medicines. Treatment necessarily continues for another 48-72 hours after the disappearance clinical symptoms diseases.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, other or additional methods contraception.

Influence on the ability to drive vehicles and control mechanisms

No adverse effect of the drug on the ability to drive was reported. vehicles or working with machinery.

Overdose

Symptoms: dysfunction of the gastrointestinal tract - nausea, vomiting, diarrhea; The consequence of vomiting and diarrhea may be a violation of the water and electrolyte balance.

Treatment: prescribe gastric lavage, activated charcoal, saline laxatives; apply measures to maintain water and electrolyte balance, hemodialysis.

drug interaction

Probenecid, phenylbutazone, oxyphenbutazone, diuretics, allopurinol, NSAIDs, to a lesser extent - acetylsalicylic acid and sulfinpyrazone inhibit tubular secretion of penicillins, which leads to an increase in T 1/2 and an increase in the concentration of amoxicillin in the blood plasma.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) show synergism when taken simultaneously.

Possible antagonism when taken with some bacteriostatic drugs (eg, chloramphenicol, sulfonamides).

Simultaneous use of amoxicillin with estrogen-containing oral contraceptives may reduce the effectiveness of the latter and increase the risk of acyclic bleeding.

Antacids, glucosamine, laxative drugs, aminoglycosides, food reduce absorption. Ascorbic acid increases absorption.

Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); enhances the absorption of digoxin.

Co-administration of amoxicillin with allopurinol increases the risk of developing skin rash.

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life - 5 years.

Flemoxin Solutab is an antibiotic used to treat tonsillitis in adults and children. There are five types of angina, differing in degree of complexity. Its purulent variety is especially dangerous, which can give complications to other organs. Flemoxin successfully treats all of them. It is prescribed to eliminate the inflammatory process and pathogenic infections. He belongs to the group penicillin antibiotics. This drug can also be taken during pregnancy. It should be drunk as prescribed by a doctor who will indicate the correct dosage.

Action

It is effective in this disease because it consists of amoxicillin, which can eliminate streptococcal bacteria. The azalides to which this drug belongs are semi-synthetic drugs derived from erythromycin. They have fewer side effects than other antibiotics of the penicillin group.

The medicine gently affects the body, has a pleasant citrus taste and aroma. When taking the tablet, you can dissolve or chew. Flemoxin for fast and effective treatment taken together with B vitamins, anti-inflammatory and antihistamines. They have a percussive effect on the focus of inflammation, destroy its pathogens and relieve swelling of the tonsils. If on the second day there is an improvement, then you should still continue to drink the medicine until the disease has completely passed.

For the most part, antibiotics have a negative effect on the stomach and intestines, and after their use, a long restoration of the microflora of these organs is required.

Therefore, many conscious parents resort to treating a child with antibiotics as a last resort. But in the case of using Flemoxin Solutab, you don’t have to worry about this, it does not cause dysbacteriosis.

The video tells about the use of Flemoxin Solutab for angina:

The drug is quickly and completely absorbed into the blood in just five minutes.

Instructions for use

Before using this medication, you should first take tests and check the sensitivity of microorganisms to the components of the antibiotic. Only after receiving the results of the analysis, the doctor will be able to determine the appropriateness of using this medication. The question arises whether it helps with angina and whether it is possible to drink / take. The drug helps not only with angina, but is also used for infectious diseases of the respiratory system, intestines, genital organs, and for various skin diseases. Here you can read about the treatment with antibiotic tablets of sinusitis. These antibiotics are also prescribed for otitis media in adults and children.

It can be drunk by pregnant women, but nursing mothers should take it with caution so that the fetus does not receive a large dose and does not have an allergic reaction.

Composition

Its main active ingredient is amoxicillin, which is used in an easily digestible form, in the form of a trihydrate. Its excipients are: vanillin, saccharin, microcrystalline cellulose, magnesium stearate, dispersible cellulose and two shock absorbers: tangerine and lemon. The antibiotic for angina Amoxicillin is also used, they can replace Flemoxin. Although it does not contain a number of excipients.

Release form

Flemoxin Solutab is available in tablet form for adults and children, and there is also a suspension. Unlike other children's antibiotics, there is no powder form for this product. For ease of use, manufacturers have divided the tablets into four types according to dosage. Each of which contains, respectively, 125, 250, 500 and 1000 mg of the main active ingredient.

The time of taking the medicine must be strictly maintained. It can be an hour before meals or at least three hours after it. In a mild form, the drug should be taken for a week, and more acute types of the disease require a two-week treatment with this remedy.

Dosage for children

A streptococcal infection will not go away immediately, so it must be destroyed within 10 days. But for each little patient, the doctor prescribes an individual course of treatment and its duration. On average, children recover in five days. Tablets are taken three times a day by children:

• from 1 to 3 years, 125 mg;
• from three to 10 years - 250 mg. Or you can drink twice a day, but then 375 mg.

The pediatrician may prescribe other dosages. On average, 30 mg of medication per 1 kg of a child's weight is considered. The calculated dose is divided into two or three doses, it depends on the preferences of the parents.

In more complex cases, the doctor may increase the daily dose or, conversely, reduce it at the first signs of improvement. For children with poor kidney function, the amount of the drug is recommended to be reduced by half. If tablets were bought instead of a suspension for a child or the remaining ones with a normal expiration date are used, then for ease of use they can be dissolved in water. It is necessary to take 100 ml of liquid and after dissolving the medicine, the necessary consistency will be obtained.

Doses of the drug for adults

Tablets should be chewed, and if this does not work, then it should be dissolved in water. For mild to moderate disease daily dose for an adult patient is from 0.5 to 2 grams. This amount of medicine must be taken in two approaches. At serious illnesses the dosage is set by the therapist.

Contraindications

The main undesirable indicator is individual hypersensitivity to the ingredients of the drug. It should be taken with caution by people suffering from kidney failure, colitis, allergies, as well as lactating women and pregnant women.

Do not combine this drug with the following medicines:

Side effects include: diarrhea, development of nephritis and dyspepsia. Sometimes there are allergic reactions in the form of rashes on the skin. However, this does not happen as often as after the use of ampicillin.

Flemoxin Solutab is an ideal option for the treatment of angina, especially in children. The effectiveness and easy tolerability of the drug by kids of different ages has earned him particular popularity among antibiotics. Everything more people prefer this drug. It is also influenced by the fact that this drug can be used not only for the treatment of angina, but also in the complex therapy of otitis media, pneumonia and bronchitis. It describes the treatment of bronchitis with antibiotics. Here you can read about the treatment of acute pharyngitis with antibiotics. Follow the link for a list of antibiotics for tonsillitis in children.

Learn how to treat laryngitis in a one year old.

From what age can Bioparox be used for children.

Hexoral Spray Reviews: Reviews

• Lyudmila, 38 years old:“An antibiotic from Astellas Pharma called Flemoxin Solutab was first prescribed by a pediatrician to my child last year. This medicine is produced in the Netherlands. One package contains four blisters of five tablets. In this case, each elongated capsule can be separated along the specified cutting line. A lot of space was left between the pills for ease of use. My child had a severe cough, a sore throat and all this caused a high temperature. The son was a little more than a year, and the doctor prescribed us antibiotic tablets, which surprised me. After all, before that we had already encountered similar drugs, and they came in suspensions. But this form of medicine did not cause us any special difficulties. The dose indicated by the doctor was half a tablet. It broke easily along the dividing line on the capsule. Then I dissolved it in warm tea and the child drank it without noticing that he was drinking medicine. Recovery came quickly enough, it was not accompanied by any side effects. Therefore, from my own experience, I can advise you to use this drug for angina.
• Svetlana, 28 years old:“Flemoxin Solutab is one of those drugs that I trust and am 100% sure of their effect. It is a wide range of applications. It has the same composition as Ospamox, Amosin and Augmentin, but they all act differently. I prefer a foreign drug because it does not contain unnecessary impurities and its action is faster. Therefore, if a doctor prescribes an antibiotic based on amoxicillin to someone from our family, then I choose Flemoxin Solutab or Augmentin. But the first drug seems to me more reliable and effective. We treat them with otitis media and tonsillitis. Sometimes we resort to it with the manifestation of bronchitis. Tablets suit me just fine. Usually, special suspensions are used for children, which must be kept in the refrigerator. And Flemoxin can be dissolved in water or simply chewed.
• Evgenia, 22 years old:“Last winter, we were twice in the hospital with the child. The experience is not pleasant, you will not advise anyone to be there. Especially injections, which both I and my child cannot tolerate. Once again, my daughter fell ill with a sore throat, and even complex shape. I thought they would put us in the hospital again, but the doctor took pity on us and prescribed a potent remedy - Flemoxin Solutab. He helped very quickly, relieved inflammation and eliminated infections. I want to note its advantages and what I did not like about it. Pros: pills, not injections. For us, this is salvation; speed; can be used for one-year-old crumbs; with angina relieves symptoms already on day 4 (I give data from personal experience); The child improved on the second day. Without antipyretic drugs, Flemoxin brought down the temperature to 37.2 and it did not rise any more. And a day later, she left altogether; there are different dosages of the drug; affordable price; you can drink without regard to food intake; the taste is pleasant and resembles tangerines; no side effects were observed when using it. The negative aspects are: it is an antibiotic and should not be drunk without a doctor's prescription; to preserve the intestinal microflora, it is necessary to take beneficial bacteria in parallel so that there is no dysbacteriosis.

Flemoxin sollyutab for angina: the effectiveness of treatment

Flemoxin Solutab – a drug that active substance is an antibiotic of the penicillin group. It is prescribed to children and adults with purulent tonsillitis, bacterial infections respiratory organs and for the treatment of various inflammations. The drug is also prescribed for viral diseases, if as a result of infection the microflora of the mucous membranes was disturbed and a bacterial infection joined. How is flemoxin solutab taken for angina? How effective is this drug for treating a sore throat? And does flemoxin solutab help with angina by 100%?

Description of the drug

The therapeutic effect of flemoxin solutab is provided by the antibiotic amoxicillin. It has a wide spectrum of action, is active against streptococci, some types of staphylococci, gonococci, meningococci, tetanus bacillus, anthrax, Helicobacter. Amoxicillin is less effective against enterococci, salmonella, shigella. And it is completely inactive against those bacteria that form beta-lactamase (Pseudomonas aeruginosa, Escherichia coli, serrations, enterobacteria).

The absorption of the drug is 93%. It penetrates into the mucous membranes, tissue fluid, connective tissue, sputum, where it inhibits the pathogenic flora and stops the reproduction of pathogenic bacteria. Like all antibiotics, together with the pathogenic flora, amoxicillin is inhibited by friendly and useful to man bacteria, causing dysbacteriosis of the mucous membranes (intestines, nasopharynx).

Depending on the amount of amoxicillin in the preparation, there are tablets of 125, 250 and 500 mg of the active antibiotic. In addition to the antibacterial component, the drug contains sugar and vanillin, mandarin and lemon flavor, magnesium stearate and cellulose.

Therapeutic dose

Like any antibacterial drug, flemoxin solutab for angina in children and adults requires a medical prescription. In what dosages is this medicine taken:

• Flemoxin solutab for angina in adults is prescribed 1500 mg per day for 2 or 3 doses (a similar scheme is for children over the age of 10 years).
• Children over 3 and under 10 years of age receive 750 mg per day (also in 2 or 3 divided doses).
• After a year to 3 years - 500 mg per day.
• Up to 1 year - the calculation of the daily dose depends on the body weight of the child and is 30 mg per kg of the baby's weight.

The choice of the number of doses of the drug (two or three per day) is determined by the complexity of the course of the disease. In case of severe infection, extensive infection, the daily dose of flemoxin solutab is divided into 3 equal parts, the treatment lasts 10 days. With an average extent of infection, the antibiotic is prescribed in two doses, the duration of treatment is up to 7 days. After the disappearance of painful symptoms, the drug is continued to be taken for another 2 days.

In case of severe infections, the above dosages are increased by 1/3 (for example, instead of a tablet of flemoxin solutab 500 mg, tablets of 750 mg are prescribed for tonsillitis with purulent boils, if the amount of the drug is selected to a small child, then instead of 30 mg / kg of weight, 50-60 mg / kg are prescribed).

Flemoxin Solutab: instruction

With angina, flemoxin solutab is prescribed as the main treatment. Tablets of the drug can be chewed, divided into parts, crushed into powder or made into a suspension (dissolved in water).

Contraindications to treatment with flemoxin solutab are diseases of the kidneys, liver and gastrointestinal tract, allergic reactions, infectious mononucleosis, as well as pregnancy and lactation. In the presence of these diagnoses, the drug is prescribed very carefully.

During treatment, the following manifestations are possible:

• Nausea, diarrhea, vomiting and other signs of gastrointestinal dysfunction.
• Allergic rash.

With the appearance of these complications, a person is given laxatives and adsorbents, as well as drinking plenty of water. Treatment with this antibiotic is canceled.

Treatment effectiveness

The presence of different reviews about the effectiveness of the drug (positive and negative) is due to the lack of a complete examination before treatment and not always competent prescription of the drug. Amoxicillin may be of little or no effect against a number of bacterial pathogens(Pseudomonas aeruginosa and Escherichia coli, Enterobacteriaceae). Therefore, before prescribing the drug, it is necessary to determine the type of infectious agent.

Negative reviews raise the question for an ordinary person without a medical education, is it possible to take flemoxin solutab with angina? And how to determine whether the drug will help in the treatment?

Flemoxin solutab: is it possible with angina?

Flemoxin solutab is one of the most commonly prescribed drugs for angina. It is also taken to treat a number of other inflammations (ENT, urinary organs, skin). The formation of side effects depends on the allergic mood of the body, on the presence of other diseases and inflammations.

More often than other complications are observed in children under the age of 1 year in the form of diarrhea and rash. Is it possible to drink flemoxin solutab with angina in an infant? The choice of treatment should take into account the following factors:

• The effectiveness of the antibiotic against this pathogen (for this, it is necessary to analyze the bacterial flora of the sore throat).
• The reaction of the baby's body to this antibacterial drug (manifested after taking, requires observation).

In adults side effects appear much less frequently than in children.

Flemoxin solutab: properties and therapeutic effect in angina

The cause of angina is infectious, streptococci are responsible for the development of inflammation. Treatment requires the use of antibiotics, which inhibit the growth of microorganisms. Flemoxin solutab for angina is prescribed for adults and children.

Description of the drug and benefits

Semi-synthetic antibiotic with stable action against several types of bacteria. Produced by the Dutch company Astellas Pharma. The active ingredient is amoxicillin. Obtained from penicillin by changing it chemical formula. Amoxicillin blocks the production of cell membrane components in bacteria and causes death. This property is used for infections of the respiratory system, digestion, genitourinary system and skin.

Substances of the drug are not destroyed by the action of hydrochloric acid in the stomach, in medicinal purposes taken regardless of the diet. The pill collapses inside gastrointestinal tract components are absorbed and carried by the blood.

Among the advantages of the drug it is worth noting:

• the active substance amoxicillin trihydrate is easily absorbed;
• different dosage creates ease of use;
• treats skin diseases;
• does not affect the nervous system.

Rules for taking the drug

Instructions for use

1. Flemoxin solutab is produced in tablets for adults. The dosage of the drug is from 125 mg to 1000 mg. The tablet is oblong with rounded edges, applied to the surface of the mark helps to split in half in case of a smaller dose. The tablet is swallowed whole or chewed.
2. For children, a mandarin-flavored suspension is produced. The doctor, according to the patient's condition and based on the tests, prescribes the dosage of the drug. The tablet is easy to divide and dissolve in water, no sediment remains. It can be swallowed whole or chewed and washed down with water. You can prepare syrup and suspension from the tablet. It must be dissolved either in 10 ml of water, or in 100 ml as desired.

In the blood, the concentration of the active substance reaches a maximum after 2 hours. The dosage and frequency of use directly depends on the severity of the sore throat.

Flemoxin for children with angina is prescribed based on its mild but effective therapeutic effect. Another positive quality of the drug is that it does not have a detrimental effect on the intestinal microflora, which means that it does not have to be restored by taking probiotics.

The package contains 20 tablets with different dosages of the active substance and instructions. When prescribing an antibiotic, a urine culture is necessary to establish sensitivity to amoxicillin.

With purulent sore throat, vitamin B, anti-allergy and anti-inflammatory drugs are taken together with an antibiotic. Flemoxin copes with the infection and on the third day the patient notices an improvement in well-being. The minimum course of admission is 5 days, regardless of the absence of symptoms of the disease.

Side effects

1. Flemoxin solutab with angina can cause an allergic reaction in children and adults. Do not prescribe a drug for treatment if a person is allergic to penicillin.
2. In most cases, the drug does not cause side effects, but there is a possibility of diarrhea, skin rashes, discoloration of the teeth, dizziness.
3. Take with caution in colitis, renal failure and pregnancy.
4. In clinical trials, the drug has been proven to be safe. But if the patient notes changes in well-being, he needs to stop taking Flemoxin.

Treatment of angina in children

With angina, the likelihood of complications is high. A disease that has not been given due attention and treatment will worsen the condition of cardio-vascular system. High risk of developing rheumatic fever.

The symptoms of colds are similar and for this reason self-medication is dangerous. The help and examination of a pediatrician is necessary for a child at any age.

By prescribing and taking Flemoxin, it is possible to normalize the condition in a short period, reduce sore throat and lower the temperature.

Young patients have more "claims" for drugs. In children, Flemoxin Solutab is used for angina because of its convenient liquid form, the taste does not cause negative emotions. There is no need to resort to lengthy persuasion of children.

Take the antibiotic according to the instructions and monitor its regular use. The course is observed prescribed by the doctor:

The dose for children with angina according to the instructions for Flemoxin Solutab is calculated strictly:

• for patients under 3 years of age, 250 mg x 2 per day;
• from 3-6 years - 375 mg x 2 per day;
• after 6 years, the daily dosage is from 30 to 60 mg per 1 kg of weight, depending on the severity of the disease;
• from the age of 10, the dosage is the same as in adult patients.

Parents, while taking an antibiotic, monitor the appearance of side effects in order to notice and contact the doctor in time for further adjustment of actions.

Be careful if your child is taking other medications. Do not combine antibiotics of the same type at the same time sulfa drugs. The doctor will be notified about the medicines that the baby has received or is taking.

In children, Flemoxin treats other inflammations respiratory system: otitis media, bronchitis, pneumonia. Parents' reviews contain information that the therapeutic effect manifests itself quickly, even at high temperatures. Side effects are rare, and dosage adjustment helps to avoid their manifestation.

Combination with other drugs

Flemoxin works in "alliance" with many drugs, which allows it to be used for complex therapy. The combination with acetylsalicylic acid leads to congestion in the intestines. Joint use with Metronidazole and aminoglycosides increase the antibacterial activity of Flemoxin. The effect of contraceptives, on the contrary, is reduced.

Therapy of angina in adults

Flemoxin 1000mg for adults

Flemoxin with angina in an adult requires other, higher doses. Assign at least 1000 mg per day. If the course is difficult, the dosage is increased, but only at the discretion of the doctor. Flemoxin treats inflammation of the ear, maxillary sinuses, etc.

While taking the antibiotic, it is allowed to drive vehicles and work on special equipment. Combination with alcohol is prohibited.

You cannot self-medicate with antibiotic therapy. Microorganisms are able to adapt and do not react to the active substance. Therefore, taking antibiotics does not have the desired effect. Even after reading the instructions for an antibiotic, this does not give you the right to take it without a doctor's prescription.

Disadvantages: did not find

The antibiotic Flemoxin Solutab was prescribed to me and my young man with purulent tonsillitis. It so happened that both fell ill, but I was a little earlier. Therefore, the treatment proceeded also a little differently.

It was prescribed to take 1000 mg twice a day for 5 days. In nearby pharmacies, this dosage was not available, so they took 500 mg each. You can take it before or after a meal, we took it 30 minutes before meals, on an empty stomach, two in the morning and two in the evening.

Important screenshots from instructions:

Tablets of sweet taste, like sweets, are easily cracked, large, but it is not difficult to swallow.

Available dosages: 125 mg, 250 mg (children), 500 mg and 1000 mg. 20 tablets per package in 4 blisters of 5 pcs.

Price: something strange is going on with prices, at least here in Astana. In one place, 500mg costs 1860 tenge (330r) in another 2650 tenge (480r) - a decent spread. Depending on the dosage (child / adult), the price does not vary. Children's in 125 mg will cost you the same amount as 500 mg. But 1000 mg is already two to two and a half times more expensive.

I am of the opinion that if the bacterium is not killed in time and not cured to the end, then it will mutate and become stronger, the disease can flow into a chronic form. Why do I need this?!) Despite the decrease in exacerbation and improvement in well-being, I still decided to drink an antibiotic. Started taking after the recession of the crisis and high temperature, two days after acute pain, at this point the temperature did not rise above 37.5 degrees.

Reception began immediately during the period of exacerbation. Along with taking antibiotics, continued and heat, kept in the region of 38-39 degrees for the first three days, after churning it grew again. Although, in theory, the antibiotic for such a period should already somehow have a greater effect on the focus of the disease. Well, I think so, I'm not a doctor, I'm just thinking. Moreover, the reception was prescribed for only 5 days.

None of the side effects described in the instructions came out and showed up, no itching, no nausea, no dizziness or pain in the stomach.

In general, I am satisfied with the reception. In addition to the antibiotic, there were also sprays, rinses and folk recipes. Together, I was healthy already 3 days after the start of the reception (I just finished the prescribed course of antibiotics to the end), mch - after 7 days. Throat no longer bothers.

Thank you all for your attention to the review!) Be healthy)

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International name:
Amoxicillin (Amoxicillin)

Group affiliation:
Antibiotic, semi-synthetic penicillin

Description of the active substance (INN):
Amoxicillin

Dosage form:
granules for the preparation of a suspension for oral administration, capsules, powder for the preparation of drops for oral administration, powder for the preparation of a solution for intravenous and intramuscular injection, powder for suspension preparation

Pharmachologic effect:
Semi-synthetic penicillin, has a bactericidal effect, has a wide spectrum of action. Violates the synthesis of peptidoglycan (supporting polymer of the cell wall) during the period of division and growth, causes lysis of bacteria. Active against aerobic gram-positive microorganisms: Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp. and aerobic Gram-negative microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp. Salmonella spp. Klebsiella spp. Penicillinase-producing strains are resistant to the action of amoxicillin.

Indications:
Bacterial infections caused by susceptible pathogens: infections respiratory tract(bronchitis, pneumonia) and ENT organs (sinusitis, pharyngitis, tonsillitis, acute otitis media), genitourinary system (pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis), abdominal infections (peritonitis, cholangitis, cholecystitis), infections skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses), leptospirosis, listeriosis, Lyme disease (borreliosis), gastrointestinal tract (dysentery, salmonellosis, salmonella carriage), meningitis, endocarditis (prevention), sepsis.

Contraindications:
Hypersensitivity (including to other penicillins, cephalosporins, carbapenems). With caution. Polyvalent hypersensitivity to xenobiotics, infectious mononucleosis, history of gastrointestinal diseases (especially antibiotic-associated colitis), renal failure, pregnancy, lactation.

Review comments

Yes, a good antibiotic for angina. Only they were saved. But at the same time I always drink a probiotic.

Shanty. Oh yes, I completely forgot, there were probiotics too. I just take them all the time, so I'm already used to having them all the time.
although the doctor herself did not write them out, which is sad ((

Sources:

For babies prone to sore throats, doctors usually prescribe antibiotics. The goal of treatment is to eliminate staphylococci and streptococci - the main culprits of infection child's body. The most effective drugs are considered, the impact of which is detrimental to the pathogenic flora. This group includes Flemoxin Solutab, a semi-synthetic penicillin that is resistant to the influence of gastric juice. It destroys the cell walls of microbes, which inevitably leads to their death.

Why is Flemoxin Solutab prescribed?

The drug is often included in the course of treatment of children for a sore throat. If a small patient needs urgent therapy without receiving culture responses for SDS antibiotic susceptibility, an age-specific dosage of medication is calculated for him. The active substance of the drug is amoxicillin, so it is sometimes called Amoxicillin.

The drug is detrimental to various aerobic gram-positive and gram-negative bacteria. It suppresses the resistance of the microorganism Helicobacter pylori to metronidazole. Cross-resistance exists between amoxicillin and ampicillin.

The widespread use of the drug for angina in children is based on a gentle effect on the body. Flemoxin Solutab has a pleasant taste. It is released in the form of tablets and suspensions. Both forms are endowed with a citrus flavor. If the tablet is painful to swallow whole, it is allowed to chew or drink dissolved in water. For small child suspension would be ideal.

Flemoxin Solutab: how to take children with angina

Flemoxin Solutab tablets are white or yellowish in color. Their dosage is represented by several variations - 125, 250, 500 and 1000 mg. For the smallest, a suspension is provided. Most often, children are prescribed Flemoxin Solutab 250. Treatment variations are as follows:

1. the drug is taken orally without reference to food intake (products do not affect absorption). The child is treated for 5-10 days, depending on the severity of the disease. After stopping the symptoms, Flemoxin Solutab tablets continue to give the crumbs for another 2 days. This measure prevents relapse.
2. If the baby knows how to drink pills, he can be offered to take the medicine as a whole. The tablet is allowed to be crushed into powder and divided into parts.
3. Therapeutic syrup for angina is prepared by crushing and stirring Flemoxin Solutab in a small amount of water (about 20 ml). A pleasant-tasting fruit suspension is independently prepared by dissolving the tablet in 100 ml of boiled water.
4. If the child has kidney problems, the dose is reduced by 2 to 4 times.

With angina of the lung and middle course, the instruction prescribes the following regimens:

• crumbs from 1 year to 3 years - 250 mg x 2 r. per day or 125 mg x 3 r. in a day.
• From 3 to 10 years - 250 mg x 3 r. per day or 375 mg x 2 r. per day.
• For children over 10 years of age, the recommended intake of the drug is 500-750 mg for a double dose or 375-500 mg for a 3-time use.

When prescribing the drug to patients of different ages, the doctor takes into account body weight. Infants under the age of one year and older children should take such an amount of medicine per day that its total amount is the result of multiplying 30-60 mg per kilogram of body weight. The resulting figure is divided into 2 - 3 receptions.

With recurrent sore throat for children, a three-time use of the remedy is provided. The daily volume is calculated by multiplying 60 mg of the drug by the total weight. A noticeable improvement occurs on the 3rd day from the start of treatment. If Flemoxin Solutab is ineffective, it is replaced with another drug.

Let's talk about side effects

Despite excellent tolerance, if the rules of use are violated, Flemoxin Solutab can cause some undesirable effects. The annotation to the drug says about possible violations in the digestive system. Children may experience nausea, vomiting or diarrhea. Sometimes babies complain of an unpleasant taste in their mouths.

Prolonged / uncontrolled use of medication for angina is fraught with adverse changes:

1. intestinal dysbacteriosis;
2. candidiasis stomatitis;
3. nervous excitability;
4. sleep problems;
5. depression, anxiety;
6. increased levels of liver enzymes in the blood.

Similar medicines

The drug Flemoxin Solutab has both domestic and foreign analogues. Their active ingredient is amoxicillin, an antibacterial compound of the penicillin group. With individual intolerance to Flemoxin, therapy for children consists of the following means:

• Ospamox;
• Ecoball;
• Amoxi;
• Hyconcil;
• Baktos;
• Amoxilate etc.

Dispersible (water-soluble) tablets contain amoxicillin in the form of amoxicillin trihydrate (Amoxicillin trihydrate), microcrystalline and dispersible cellulose, vanillin, crospovidone, flavors (lemon and tangerine), magnesium stearate, saccharin.

Release form

Flemoxin Solutab dispersible tablets:

• 125, 250, 500 or 1000 mg package No. 20 (blisters of 5 pcs., 4 blisters per pack);
• 125 mg package No. 14 (blisters of 7 pcs., 2 blisters per package).

Tablets are oval, white or white with a yellowish tint, with a separating risk on one side, and a digital designation (231, 232, 234 and 236) and the manufacturer's logo on the other.

pharmachologic effect

Antibacterial , bactericidal .

Pharmacodynamics and pharmacokinetics

Amoxicillin is a semi-synthetic β-lactam antibiotic of the penicillin group with a wide spectrum of antimicrobial activity.

Bactericidal properties The drug is due to the ability to suppress transpeptidase, disrupt the production of peptidoglycan (the supporting protein of the cell walls) during periods of division and growth, and provoke the lysis of microorganisms.

Shows activity against Gram (+) aerobes, including Staphylococcus spp. (with the exception of penicillinase-producing strains) and Streptococcus spp. (including Str.pneumoniae and faecalis); Gram (-) aerobes (gonococci, meningococci, Escherichia and Haemophilus influenzae, Proteus mirabilis; individual strains of Klebsiella, Shigella and Salmonella, as well as against H. pylori.

It is ineffective against strains of Proteus P. rettgeri and vulgaris (they are indole-positive), serrations, pseudomonads, enterobacteria, morganella morgani. Resistant to the action of amoxicillin mycoplasma, rickettsia and viruses.

A feature of the dosage form is that the tablets are easily dispersed in water to form a dispersion. Due to this, the drug is quickly and as completely as possible (more than 93% of the dose taken) absorbed from the alimentary canal.

Eating does not affect the absorption of the substance. TCmax - ranging from 60 to 120 minutes. When taking dispersible tablets, the plasma concentration of amoxicillin is higher than when taking insoluble forms of the drug. The active substance is resistant to acids.

TCmax when taking 500 mg of amoxicillin - 120 minutes. When taking twice the or half the dose of the drug, the Cmax also changes twice.

Approximately 20% of the dose taken is bound to plasma proteins. amoxicillin . The substance in therapeutically effective concentrations penetrates well into bone tissue, mucous membranes, sputum and intraocular fluid. Its concentration in bile is 2-4 times higher than the plasma concentration, in the amniotic fluid - from 25 to 30% of the plasma concentration in the body of a pregnant woman.

Through the BBB amoxicillin goes badly, but inflammation of the meninges its concentration in cerebrospinal fluid is about ⅕ of the plasma concentration.

The substance is metabolized partially, most of the metabolic products are inactive in relation to pathogenic microflora .

Excretion is carried out by the kidneys. In patients with healthy kidneys T1 / 2 - from 60 to 90 minutes, in children under the age of six months (including premature babies and newborns) - from 3 to 4 hours. In case of violations of liver function, the indicator does not change, if kidney function is impaired, it can increase up to 8.5 hours (this is T1 / 2 of amoxicillin in anuria).

Indications for use: from what tablets Flemoxin Solutab?

Indications for the use of the drug - bacterial infections of the organs of the external respiratory system ( , pneumonia , , , , acute inflammation of the middle ear ), organs of the genitourinary system ( ,pyelitis , , , , ), skin and/or soft tissues ( impetigo , erysipelas , secondarily infected dermatoses ), digestive organs and abdominal infections ( angiocholitis , peritonitis , typhoid fever , , salmonellosis , , salmonella carriage ), if they are caused by bacteria sensitive to Flemoxin.

Flemoxin - what is it used for in pediatrics?

Flemoxin Solutab is the most commonly used penicillin drug in pediatric practice. Most often it is prescribed for bacterial infections of the respiratory system.

The experience of practical application proves the high efficiency of Flemoxin in sinusitis , acute nonpurulent otitis media , bronchitis , bronchopneumonia , tonsillitis , sore throat .

The drug is safe, well tolerated by young patients of any age and, which is no less important when it comes to the treatment of children, has excellent organoleptic properties.

Contraindications

Flemoxin is not prescribed for hypersensitivity to amoxicillin , other β-lactams or tablet excipients.

Relative contraindications for the antibiotic Flemoxin Solutab:

• kidney failure ;
• history of gastrointestinal pathology (especially antibiotic-associated colitis);
• pregnancy;
• lactation;
• breastfeeding period;
• polyvalent hypersensitivity to chemicals foreign to the body (xenobiotics).

Side effects

Side effects appear as:

• nausea, taste changes, diarrhea, vomiting, moderate increase in liver enzymes (sometimes), hemorrhagic and pseudomembranous colitis (rarely);
• interstitial nephritis (rarely);
• hemolytic anemia , neutropenia , ,thrombocytopenia .

When using the drug in the form of dispersible tablets, no adverse events from the nervous system were noted.

The use of the drug may be accompanied by the development of hypersensitivity reactions, which are expressed in the form of a rash (mainly specific maculopapular), erythema multiforme exudative (seldom), And (in exceptional cases).

Tablets Flemoxin Solutab: instructions for use

How to take Flemoxin tablets for adults?

The drug is taken orally, without being tied to the time of the meal.

The tablet can be dissolved in 20 ml of water until a syrup is obtained or in 100 ml of water until a suspension is obtained, it can be swallowed whole or taken in crushed form.

For mild and moderate infections, 250 mg tablets are taken in 2-3 pcs. 2 rubles / day, 500 mg tablets - 1-1.5 pcs. 2 rubles / day, tablets 1000 mg - half 3 rubles / day.

In the treatment of severe diseases, as well as infections with hard-to-reach foci, it is considered preferable to take the drug three times a day.

Daily dose antibiotic with severe infections, relapses and chronic pathologies - 1.5-2 tab. 500 mg 3 r./day

When flowing without complications acute shows a single dose of Flemoxin C (dose, respectively, 3 and 1 g).

In severe infections and chronic pathologies, the treatment regimen is selected taking into account the characteristics clinical picture diseases.

In case of kidney damage, in which the Clcr indicator is in the range from 15 to 40 ml / min, the interval between taking the tablets should be increased to 12 hours. If the Clcr does not exceed 10 ml / min, the dosage of amoxicillin should be reduced by 15-50%. With anuria, the highest daily dose of amoxicillin is 2 g.

How to take Flemoxin tablets for children?

Children's Flemoxin are tablets with a dosage amoxicillin 125 and 250 mg. The instructions for children indicate that it is more convenient for a younger child to give a syrup or suspension, older children can swallow the tablet whole or after chewing it.

Instructions for the use of Flemoxin for children over 10 years old are similar to instructions for adults: for infections of a mild and moderate course, a child is given 3-4 tablets. 125 mg 3 rubles / day.

Flemoxin Solutab for children over 3 years old is prescribed to take 3 tablets. 125 mg 2 r./day. or 2 tab. 125 mg 3 rubles / day.

For children under 3 years old, according to the instructions for use, Flemoxin Solutab 125 mg, tablets are given two 2 times a day. or one 3 rubles / day.

Dosage of Flemoxin Solutab for children, which contains 250 mg amoxicillin next:

• 2-3 tab. 2 rubles / day - patients older than 10 years;
• 1 tab. 3 rubles / day - patients 3-10 years old;
• 1 tab. 2 rubles / day or 0.5 tab. 3 rubles / day - Patients younger than 3 years of age.

The daily dose of Flemoxin Solutab for children of all age groups (including children of the first year of life) is from 30 to 60 mg / kg, divided into 2 or 3 doses. If the disease is severe or the pathological focus is difficult to access, it is preferable to take the drug 3 times a day.

For severe infections (including those with hard-to-reach foci), the recommended dose of the antibiotic is 60 mg / kg / day, divided into three doses.

Duration of treatment

The course duration for mild and moderate infections is from 5 days to 1 week. If the causative agent of the infection is Str. pyogenes, treatment lasts at least 10 days.

For severe infections, the medication should be continued for 48 hours after the symptoms disappear.

Antibiotic Flemoxin Solutab for angina

Angina - is common acute infection , local manifestations of which are lesions tonsils (mainly the first and second - palatine). The most common pathogens sore throats - B-hemolytic streptococci of group A. Staphylococci provoke it much less often.

Untreated or undertreated angina gets complicated paratonsillitis , jade , myocarditis , paratonsillar abscess , tonsilogenic sepsis .

Given the bacterial nature of the disease, timely application is very important. antibiotics . If at catarrhal angina in some cases, the patient is enough antibiotics local action, then follicular and lacunar angina the doctor without fail prescribes drugs of systemic action.

Research results and practical experience have shown that the most effective means at sore throat are drugs of the penicillin group.

The advantages of Flemoxin over analogues are:

• unique dosage form (Solutab);
• the presence of tablets with a "child" dosage of the active substance;
• the possibility of using the drug without being tied to the time of eating.

Adults at sore throat the drug is recommended to take 2 rubles / day. 500-700 mg. At sore throat in children, children's Flemoxin Solutab is used - tablets with a minimum dosage of the active substance. The dose is selected by the doctor depending on the age of the patient and the characteristics of the course of the disease.

After the symptoms have subsided sore throats (the body temperature will decrease, the pustules on the tonsils will disappear, the sore throat will disappear, the condition of the lymph nodes will normalize), Flemoxin should be continued for at least two more days.

If treatment is stopped immediately, the risk of recurrence of the disease is high. Moreover, the symptoms can appear with a vengeance.

The use of the drug for sinusitis

Sinusitis - this inflammation of the paranasal sinuses .

Application antibiotic at sinusitis it is advisable if the disease is caused by bacteria that are sensitive to its action. When associated with a viral or fungal infection, as well as when allergic sinusitis , antibiotic therapy is not only ineffective, but can also aggravate the course of the disease.

Acute bacterial sinusitis appears first:

• hyperthermia (temperature febrile and above);
• violation of nasal respiration and phonation;
• soreness and swelling of the skin in the projection of the maxillary cavities;
• decreased sense of smell;
• the presence of pains radiating to different parts of the face (pains gradually lose their specific location);
• symptoms of general intoxication (sleep disturbances, headache, aching joints, etc.);
• the characteristic color of the pathological secretion discharged from the sinuses (its color in bacterial infections usually varies from yellow to dark green).

The choice of antibiotic is carried out taking into account:

• the results of a microbiological study of a biomaterial taken from the paranasal sinuses and an express test for staining the pathogen using the Gram method;
• characteristics of the patient's body;
• possible allergic reactions to the drug;
• the presence of comorbidities.

If the cause of the disease is staphylococci, streptococci or Haemophilus influenzae, the most preferable is the appointment of penicillin group drugs to the patient.

Application amoxicillin at bacterial sinusitis (including with complicated forms of the disease) gives a pronounced positive effect already in the first 7 days of treatment: the patient's symptoms of intoxication and pain in the paranasal sinuses decrease / disappear, the temperature decreases and nasal breathing is facilitated.

The effectiveness of Flemoxin Solutab is explained by the fact that this drug:

• affects a large number of strains of infectious agents;
• quickly and in high concentrations absorbed from the digestive tract;
• resistant to the action of gastric juice;
• available in an easy-to-use form.

Overdose

Symptoms of an overdose of Flemoxin Solutab: nausea, diarrhea, vomiting, impaired water-salt balance.

Treatment: gastric lavage, the appointment of enterosorbents, saline laxatives, taking measures aimed at correcting the balance of water and electrolytes.

Interaction

Phenylbutazone , probenecid , oxyphenbutazone and, to a lesser extent, sulfinpyrazone and ASA inhibit secretion antibiotics of the penicillin group , which leads to an increase in T1 / 2 and an increase in plasma concentration amoxicillin .

Bactericidal antibiotics (including , , cephalosporins And aminoglycosides ) render synergistic action in the case of their use in combination with Flemoxin.

When taken simultaneously with certain bacteriostatic agents ( sulfonamides , chloramphenicol etc.) antagonism is possible.

The use of oral contraceptives containing estrogen may lead to a decrease in the effectiveness of the latter and an increase in the risk of rupture bleeding.

Use in combination with allopurine as opposed to combination from allopurine does not increase the frequency of skin reactions.

Terms of sale

On prescription.

Storage conditions

Store below 25°C.

Best before date

Five years.

special instructions

Having a history erythroderma is not a contraindication to the use of the drug.

The possibility of developing cross-resistance with cephalosporins And antibiotics of the penicillin group .

As in the case of the use of other drugs of the penicillin group, the development of superinfection is possible.

Characteristic for pseudomembranous colitis severe diarrhea during treatment with the drug is a reason for the abolition of Flemoxin.

In patients with lymphocytic leukemia And infectious mononucleosis , but - and this is the difference between him and Flemoxin - to enhance its action, the drug also includes clavulanate (or clavulanic acid ) is a substance that inhibits bacterial beta-lactamase enzymes.

I.e Flemoklav is active against sensitive amoxicillin microorganisms, as well as against bacterial strains that produce some chromosomal and most plasmid β-lactamases.

clavulanate inhibits type II, III, IV and V beta-lactamases, but is inactive against those produced by enterobacteria, Pseudomonas aeruginosa, acinetobacteria, serrations (type I beta-lactamases).

Having a high affinity for antibiotics penicillin groups clavulanate significantly expands the spectrum of activity and, consequently, the application amoxicillin .

Flemoxin Solutab and alcohol

For patients who are prescribed antibiotic therapy, alcohol consumption is contraindicated.

Flemoxin Solutab during pregnancy

Prescribing the drug during pregnancy and breastfeeding(HB) is possible if the expected effect of its use exceeds the risk of developing unwanted side reactions.

A small amount of amoxicillin is secreted into breast milk, which can provoke the development of sensitization phenomena in a child who is on breastfeeding.

Astellas Pharma Europe B.V. Astellas Pharma Europe B.V./Ortat CJSC Yamanuchi Europe B.V./ "ORTAT" CJSC

Country of origin

Netherlands Netherlands/Russia Russia

Product group

Antibacterial drugs

Antibiotic of the penicillin group of a wide spectrum of action, destroyed by penicillinase

Release forms

• 5 - blisters (4) - packs of cardboard 5 - blisters (4) - packs of cardboard. 5 - blisters (4) - packs of cardboard. 5 - blisters (4) - packs of cardboard.

Description of the dosage form

• Dispersible tablets

pharmachologic effect

Bactericidal acid-resistant broad-spectrum antibiotic from the group of semi-synthetic penicillins. Active against gram-positive and gram-negative microorganisms: Streptococcus pyogenes, Streptococcus pneumoniae, Clostridium tetani, Clostridium welchii, Neisseria gonorrhoeae, Neisseria meningitidis, Staphylococcus aureus (not producing beta-lactamase), Bacillus anthracis, Listeria monocytogenes, Helicobacter pylori. Less active against Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Salmonella typhi, Shigella sonnei, Vibrio cholerae. Inactive against microorganisms producing beta-lactamase, Pseudomonas spp., Proteus spp. (indole-positive strains), Serratia spp., Enterobacter spp.

Pharmacokinetics

Absorption After oral administration, amoxicillin is absorbed rapidly and almost completely (93%), acid-resistant. Eating has practically no effect on the absorption of the drug. After oral administration of 500 mg of amoxicillin, Cmax of the active substance, which is 5 μg / ml, is observed in blood plasma after 2 hours. With an increase or decrease in the dose of the drug by 2 times, Cmax in blood plasma also changes by 2 times. Distribution About 20% of amoxicillin binds to plasma proteins. Amoxicillin penetrates the mucous membranes, bone tissue, intraocular fluid and sputum in therapeutically effective concentrations. The concentration of amoxicillin in bile exceeds its concentration in blood plasma by 2-4 times. In the amniotic fluid and umbilical vessels, the concentration of amoxicillin is 25-30% of its level in the blood plasma of a pregnant woman. Amoxicillin does not penetrate well through the BBB; however, in inflammation of the meninges, the concentration in the cerebrospinal fluid is about 20% of the concentration in the blood plasma. Metabolism Amoxicillin is partially metabolized in the liver, most of its metabolites are microbiologically inactive. Withdrawal Amoxicillin is eliminated mainly by the kidneys, about 80% by tubular excretion, 20% by glomerular filtration. In the absence of impaired renal function, T1 / 2 of amoxicillin is 1-1.5 hours. In premature infants, newborns and children under 6 months - 3-4 hours. Pharmacokinetics in special clinical cases, T1 / 2 of amoxicillin does not change with impaired liver function. In case of impaired renal function (CC? 15 ml / min), T1 / 2 of amoxicillin increases and reaches 8.5 hours with anuria.

Special conditions

The drug should be prescribed to patients with infectious mononucleosis and lymphocytic leukemia with caution, since there is a high probability of non-allergic exanthema. The presence of a history of erythroderma is not a contraindication for the appointment of Flemoxin Solutab®. Possible cross-resistance and cross-hypersensitivity with drugs of the penicillin series, cephalosporins. As with the use of other drugs of the penicillin series, the development of superinfections is possible. The appearance of severe diarrhea, characteristic of pseudomembranous colitis, is an indication for discontinuation of the drug.

Composition

• Amoxicillin (in the form of trihydrate) 125 mg Excipients: dispersible cellulose, microcrystalline cellulose, crospovidone, vanillin, flavors (tangerine, lemon), saccharin, magnesium stearate. amoxicillin (in the form of trihydrate) 125 mg Excipients: dispersible cellulose, microcrystalline cellulose, crospovidone, vanillin, flavors (tangerine, lemon), saccharin, magnesium stearate. Amoxicillin (in the form of trihydrate) 1g Excipients: dispersible cellulose, microcrystalline cellulose, crospovidone, vanillin, flavors (tangerine, lemon), saccharin, magnesium stearate. Amoxicillin (in the form of trihydrate) 1g Excipients: dispersible cellulose, microcrystalline cellulose, crospovidone, vanillin, flavors (tangerine, lemon), saccharin, magnesium stearate. Amoxicillin (in the form of trihydrate) 250 mg Excipients: dispersible cellulose, microcrystalline cellulose, crospovidone, vanillin, flavors (tangerine, lemon), saccharin, magnesium stearate. Amoxicillin (in the form of trihydrate) 500 mg Excipients: dispersible cellulose, microcrystalline cellulose, crospovidone, vanillin, flavors (tangerine, lemon), saccharin, magnesium stearate.

Flemoxin Solutab indications for use

• Infectious and inflammatory diseases caused by microorganisms sensitive to the drug: - infections of the respiratory system; - infections of the genitourinary system; - infections of the gastrointestinal tract; - Infections of the skin and soft tissues.

Flemoxin Solutab contraindications

• - hypersensitivity to the drug or other beta-lactam antibiotics. With caution, the drug should be used with polyvalent hypersensitivity to xenobiotics, infectious mononucleosis, lymphocytic leukemia, a history of gastrointestinal diseases (especially with colitis associated with the use of antibiotics), renal failure, during pregnancy and lactation.

Flemoxin Solutab dosage

• 1000 mg 125 mg 250 mg 500 mg

Flemoxin Solutab side effects

• From the digestive system: rarely - a change in taste, nausea, vomiting, diarrhea; in some cases - a moderate increase in the activity of hepatic transaminases; very rarely - pseudomembranous and hemorrhagic colitis. From the urinary system: very rarely - the development of interstitial nephritis. On the part of the hematopoietic system: very rarely - agranulocytosis, neutropenia, thrombocytopenia, hemolytic anemia. Allergic reactions: skin reactions, mainly in the form of a specific maculopapular rash; rarely - erythema multiforme exudative (Stevens-Johnson syndrome); in some cases - anaphylactic shock, angioedema. Side effects from the nervous system when using amoxicillin in dosage form dispersible tablets are not registered.

drug interaction

Probenecid, phenylbutazone, oxyphenbutazone, to a lesser extent - acetylsalicylic acid and sulfinpyrazone suppress the tubular secretion of penicillin drugs, which leads to an increase in T1 / 2 and an increase in the concentration of amoxicillin in the blood plasma. Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) show synergism when taken simultaneously. Possible antagonism when taken with some bacteriostatic drugs (eg, chloramphenicol, sulfonamides). Simultaneous use of amoxicillin with estrogen-containing oral contraceptives may reduce the effectiveness of the latter and increase the risk of acyclic bleeding. The simultaneous use of amoxicillin with allopurinol does not increase the frequency of skin reactions, in contrast to the combination of allopurinol with ampicillin.

Overdose

Symptoms: dysfunction of the gastrointestinal tract - nausea, vomiting, diarrhea; The consequence of vomiting and diarrhea may be a violation of the water and electrolyte balance. Treatment: prescribe gastric lavage, activated charcoal, saline laxatives; take measures to maintain water and electrolyte balance.

Storage conditions

• store in a dry place
• keep away from children
• store in a place protected from light

Information provided by the State Register of Medicines.

Synonyms

• Amoxisar, Amoxicillin, Amosin, Ospamox, Ranoxyl, Hyconcil

Antibacterial drugs in medical practice are used quite often. Flemoxin Solutab 500 (another name for amoxicillin) is one of the most commonly prescribed antibiotics. Some patients are frightened by the strong side effects that are attributed to taking drugs in this group. Therefore, often, a sick person tries by all means to avoid the use of Flemoxin or its analogue. Is it correct?

Indeed, in some bacterial diseases that occur in a mild form, without complications (for example, catarrhal tonsillitis, sinusitis), the infection can be eliminated with simple antiseptics external action (furatsilin, chlorhexidine).

However, in acute cystitis, severe follicular or lacunar tonsillitis, food poisoning, otitis media, the use of antibiotics (including Flemoxin) is not only justified, but also necessary. It is very dangerous to allow the infection to stay in the body for a long time, pathogenic microorganisms will spread throughout all systems and organs, significantly increasing the risk of developing severe complications. And Flemoxin 500 in such cases is the drug of choice.

Short-term courses of antibiotic therapy with this drug at the right dosage, as a rule, do not lead to the risk of developing serious side effects. The standard duration of taking Flemoxin in 5-10 days does not pose any threat to the body. Usually one course of treatment with this antibiotic is enough to completely cope with the infection.

Active ingredient, price and dosage

The active substance of Flemoxin is amoxicillin. It is a fairly active broad-spectrum antibiotic belonging to the penicillin series. The drug is produced in different dosages and only in tablet form. One tablet of Flemoxin may contain from 125 mg to 1000 mg of the active substance.

A dosage of 500 mg is the average for an adult. For the price, the drug belongs to budgetary antibiotics. The cost of Flemoxin directly depends on the dosage and averages from 250 to 500 rubles per pack.

Adult patients should take Flemoxin Solutab 500 on the recommendation of a doctor with established sensitivity to the antibiotic of an infection found in them. The drug successfully copes with all bacteria on which the effect of amoxicillin trihydrate in vitro has been recorded. Usually, Flemoxin is prescribed for acute infections of the respiratory tract and organs of the genitourinary system, and it has proven itself well in the treatment of bacterial lesions of the skin and soft tissues, food poisoning.

The use of Flemoxin 500 does not depend on meals. For children over 10 years of age and weighing more than 40 kg and adults, a dose of 500-2000 mg per day is usually prescribed, depending on the severity of the disease and the type of infectious agent. In severe cases, the maximum daily dose of Flemoxin is increased to 3000 mg per day. The frequency of admission should be determined by the doctor. The daily dose is usually taken two to four times.

The duration of therapy with this antibiotic is determined taking into account the severity of the disease and the resistance of pathogenic microflora. Usually, Flemoxin is prescribed in a course of at least five days (most often 1-2 weeks).

To whom the drug is contraindicated

Despite the fact that Flemoxin belongs to drugs with low toxicity and is well tolerated by the body, it is not prescribed:

• with high resistance of pathogenic microflora to antibiotics of the penicillin group;
• with individual intolerance to amoxicillin;
• with severe pathologies of the urinary system or liver;
• during pregnancy and lactation;
• at acute diseases gastrointestinal tract.

The instruction describes contraindications in more detail. It is possible to give Flemoxin 500 to children over the age of 1 year, but for babies it is still better to select a dose using a drug with a minimum dosage of the active substance - 125 mg. It is important to remember that the daily dose of the drug for the smallest is from 30 to 90 mg / kg of weight - it is divided into 2-3 doses. Only this must be done under the supervision of the attending physician with constant monitoring of the state of the baby's body. The dosage is selected by the pediatrician.

Allergic reactions when taking Flemoxin are rare. Most often they manifest themselves in the form of a skin rash, itching. At long-term treatment Flemoxin may develop dysbacteriosis, however, this side effect is characteristic of almost all antibacterial drugs. As a rule, after stopping the use of Flemoxin, all negative reactions disappear, and additional therapy is not required.

Possibility of replacement

If a persistent intolerance of the body to medicinal product amoxicillin trihydrate, it is quite possible to replace it with analogues. Currently, the pharmaceutical market has a fairly large list antibacterial agents wide range of activities at reasonable prices. Analogues of Flemoxin 500 are selected by the doctor, taking into account all the features of the disease in each case. You can not replace the drug yourself!

Depending on the type of infection and the age of the patient, the doctor may prescribe instead of Flemoxin:

• Gonoform (price 80-100 rubles);
• Amosin (60-80 rubles per pack);
• Grunamox (190-250 rubles);
• Ecoball (from 130 rubles per pack).

All of the listed drugs that replace Flemoxin can also be prescribed to children, taking into account the age and weight of small patients. It should be borne in mind that a positive review on the Internet about a particular antibiotic does not guarantee total absence the risk of complications when it is taken by other patients.

It is also taken into account that in children the manifestation of side effects from the use of antimicrobial drugs is much more likely than in adults. The immune system the child is in the formative stage, which is why the risk of allergic reactions is much higher, and they proceed more acutely than in adults.

Therefore, only the attending pediatrician, who knows his little patients well and is able to determine as accurately as possible all the possible risks from taking the medicine, can prescribe Flemoxin or its analogues to babies. To reduce the risk of developing allergic reactions, a specialist (especially against the background of long-term antibacterial treatment with Flemoxin) may additionally prescribe antihistamine drops or tablets to the child.

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