Beklazon instructions for use aerosol for inhalation. Instructions for use of beclazone

Usually a person does not even think about how he inhales and exhales. This happens reflexively and does not force our body to apply special efforts. But people suffering from diseases of the lungs and bronchi are well aware of how expensive each breath is sometimes given. In critical situations, they have to resort to the help of special inhalers that help them cope with an acute attack of suffocation. Among the numerous aerosols, the choice often falls on Beklazon Eco. This drug helps to fight bronchial asthma and allows you to inhale the air with full breasts. Beklazone Eco. Light Breathing also belongs to the same series. Aerosol for inhalation has practically no obvious differences from the previous one. medicinal product, but we will talk about some of the differences between them in this article.

A few words about the drug

"Beclazon Eco" is well known to people with a history of bronchial asthma. It is intended for inhalation use and has a dual effect. The drug simultaneously relieves inflammation and symptoms of an allergic reaction.

Thanks to its active ingredient, Beclazon Eco reduces swelling of the mucous membranes in just a few seconds after its application. This process is accompanied by a decrease in mucus secretion in the bronchi.

Most often, such a drug is prescribed in a course, so the effect becomes noticeable after about five days. After a week, the result is transformed into a pronounced and persistent. In some cases, the drug is used to relieve swelling of the mucous membranes of the nose. Quite rarely, but "Beklazon Eco. Easy Breathing" is also used locally. In this situation, it has an anti-inflammatory effect.

Release form

Referring to the instructions for use for Beclazone Eco, you can find out that the drug is sold in pharmacies in a special can. It is made of aluminum and has a built-in aerosol dosing valve. Each cylinder is equipped with an inhalation device with a cap to protect against involuntary pressure. The medicine differs in different dosages of the active substance, so in pharmacies in your city it can cost from five hundred to eight hundred rubles. Regardless of the concentration of the components, each container contains two hundred doses of the drug. This accuracy allows the patient to very accurately calculate the moment when it is necessary to purchase a new package of the drug.

It is usually up to the patients to decide which of the cans is best for them the first time they use it. In the future, they acquire exactly the form of release of the drug, which is easier for them to use than others.

The composition of the medicinal product

Both types of drugs have an identical composition, so we will not describe it separately. chief active substance is beclomethasone dipropionate. Depending on its concentration, Beklazon Eco is distinguished - 250 mcg, 100 mcg and 50 mcg. Exactly with the same dosage, another form of the drug is also produced.

Auxiliary components of "Beclazone Eco. Easy Breathing" (250 mcg and other dosage) are two substances:

ethanol;
hydrofluoroalkane.

All components of the drug are considered as safe as possible for human health. In addition, the instructions for "Beclazone Eco" (250 mcg) noted that it rarely causes side effects. Of course, they are still available, but they occur in a small percentage of patients.

Some features of the drug

Each form of release of this drug has its own distinctive features, which we will now list. First of all, let's talk about Beclazone Eco. When buying a medicine, you should carefully examine the can. Since the drug is under pressure in it, it is necessary to exclude any chips, jams and other damage to the integrity of the package. If you notice leakage, then immediately change the packaging to another. Under no circumstances should this bottle be used. Some patients test the drug by spraying it on a transparent surface. For example, Beklazon Eco inhalation aerosol will leave a white mark. Sometimes it resembles milk spread over glass.

"Beklazon Eco. Easy Breathing" is distinguished by its design. We have already mentioned that it is initially placed in an inhaler, which consists of two parts. A protective cap must be present in the package without fail. When checking the balloon, the patient should carefully inspect the nebulizer and outlet valve. They should not have damage, bruising and obvious traces of leakage of the drug. If sprayed on a glass surface, the trace will be colorless. This should be taken into account, because those who use Beklazone Eco in reviews often doubt the authenticity of a different form of its release precisely because of the color and consistency of the trace that the aerosol leaves on surfaces.

Indications for use

"Beclazon Eco" (250 mcg, 100 mcg and 50 mcg) has a not too wide list of indications. In some reviews, it is noted that it is rather narrow and depends on the method of application of the drug.

If we are talking about the inhalation method, then the doctor will prescribe medicine to patients with bronchial asthma. Moreover, the drug is prescribed, first of all, not to relieve acute attacks, but to obtain a pronounced and persistent therapeutic effect in the course of treatment. "Beklazon Eco" is suitable for the treatment of even the most severe types bronchial asthma including hormone dependent.

The doctor may prescribe the drug intranasally to the patient. As such, it is excellent for the treatment of chronic and seasonal rhinitis of any course. Allergic rhinitis, which are difficult to remove with antihistamine drugs, also fall into the same category.

Few people know that the instructions for Beclazone Eco also mention the possibility of its external use. In such cases, it is used as part of complex therapy. Appointment is carried out with infectious and inflammatory diseases appearing on the skin. Also, the medicine is suitable for the treatment of ear infections. In parallel with the aerosol, the specialist prescribes and antimicrobials.

Complete list of contraindications

The use of Beclazone Eco is not shown to all patients. Despite the fact that the drug is quite safe, some diseases and health problems will become an obstacle to the use of the drug we are describing.

Naturally, the drug should not be used in cases of detection of some individual intolerance. Otherwise, a serious allergic reaction may develop, which will only aggravate the course of bronchial asthma.

In no case should Beklazone Eco be prescribed to babies under the age of four years. At an older age, only the doctor determines the dosage.

Separately, it is worth listing the categories of people who can use this drug with some restrictions and only under the close supervision of the attending physician.

This list primarily includes pregnant women and women in the period breastfeeding. Also, the use of "Beclazone Eco" in case of diagnosed glaucoma, cirrhosis of the liver and infection with Koch's bacillus raises big questions. Generally, infectious diseases refer to contraindications for the use of an aerosol for inhalation.

Negative consequences

The drug gives few side effects, but they are still worth listing so that patients are ready for such sensations. Many write in their reviews that literally after the first applications they noticed hoarseness. The irritation of the mucous membrane of the throat is just as often manifested. These side effects were encountered by almost all patients taking Beclazone Eco.

Often, patients experience candidiasis, the likelihood of its occurrence increases significantly in cases of using the highest possible concentration of the drug.

Sometimes the drug causes spasm in the bronchi. This side effect cannot be ignored, it must be removed with special means. Otherwise, patients may experience an allergic reaction. It is accompanied by severe skin itching, rashes and hypersensitivity. In parallel, swelling of the mucous membrane of the oral cavity and lips is possible.

Often, the body can react to an aerosol for inhalation with nausea and a change in taste preferences. Some patients write in reviews about headache, thinning skin and osteoporosis.

In children who have been prescribed Beklazone Eco from an early age, there is in some cases a delay in physical development. It is expressed in a decrease in growth rates. A similar side effect can occur in adolescents.

How to apply the drug?

The instructions for use for Beclazone Eco (250 mcg) provide all the ways to use it. According to them, the drug is only suitable for inhalation, this is also evidenced by its release form.

It is noteworthy that it is necessary to take the medicine regularly in courses. You should not hope that you can limit yourself to only acute attacks. If you want to completely get rid of asthma, then the treatment should be regular in the dosage determined by the doctor. The specialist always focuses on the course of the disease, subdividing it into three categories:

easy flow;
moderate course;
severe course.

To determine the nature of the disease, special studies and terms are usually used. First of all, the doctor pays attention to the peak expiratory flow rate and forced expiratory volume.

Most often, the daily dosage is divided into several applications. At the beginning of treatment, the doctor carefully monitors the patient's condition and timely adjusts the concentration of the drug. It can both increase and decrease until the optimal dosage is found.

Instructions for use

Keep in mind that only the attending physician can prescribe the required amount of the drug, however general recommendations can always be found in the instructions. For example, children between the ages of four and twelve should not be prescribed dosages greater than four hundred micrograms. However, it should be divided into several methods.

Older patients receive medication depending on the severity of the course of bronchial asthma. lung disease The current requires for treatment a dosage ranging from two hundred to six hundred micrograms.

If you have been given average degree diseases, then the patient should take from six hundred to one thousand micrograms of "Beclazone Eco" per day. In the most severe cases, the dosage may be increased to two thousand micrograms.

Features of the treatment of bronchial asthma

If you have been diagnosed with such a disease, then you should not be upset. The disease is treatable, but for this it is necessary to listen to the recommendations of the doctor and be prepared for a long struggle, consisting of several stages. Therapy is prescribed only when the attending physician determines the severity of the disease and, focusing on it, adjusts his recommendations.

Keep in mind that on initial stage aerosol for inhalation will not be prescribed. The first stage does not imply such a form of treatment. But the second and third involve basic therapy with different dosages. However, it should be borne in mind that in the second stage, the daily dose should not exceed four hundred micrograms, divided into two doses. The third stage allows complex therapy, while the dosage of Beclazone Eco is increased to one thousand six hundred micrograms per day.

Severe course of the disease falls under the fourth and fifth stages of therapy. In such cases, it is always characterized as complex, and the dosage sometimes reaches two thousand micrograms of the drug.

Proper use of the inhaler

Each form of release of the drug we are describing has its own scheme for using the inhaler and cleaning it. When we talk about "Beclazone Eco", then it is necessary to act as follows. After removing the cap, make sure that the tube is not clogged with dust and medication residues. Then grasp the can with your index finger and thumb, shaking it vigorously several times. Next, you need to exhale to completely empty the lungs and tightly clasp the tube with your lips. Inhalation should occur parallel to pressing the dispenser button with your finger and be very slow. After that, you need to hold your breath for about ten seconds. The main thing is to do everything consistently and without tension. You should literally feel the medicine fill your lungs.

Cleaning the inhaler with regular use is necessary once every seven days. For this purpose, the can is pulled out of the plastic inhaler, which is washed with warm water. Under no circumstances should you use hot water and hair dryer or other heating devices for drying.

"Beklazon Eco. Easy Breath": how to use

This form of the drug has two types: with and without an optimizer. If you use the last of these options, then the sequence of actions will be as follows. The patient must turn the device vertically and open the lid. Fingers should not block the outlets at the top of the inhaler. While inhaling, tightly wrap your lips around the tube and make deep breath medicines. Hold your breath for as long as your lungs will allow, but do not change the position of the balloon. After the procedure, the inhaler must be closed with a lid.

If you bought a drug with an optimizer in the kit, then before using it, you must put it on the inhaler tube. After the procedure, it must be removed and the device closed with a lid.

Cleaning such an inhaler requires some skills. Under warm water, only its lower part is washed, but the upper part during normal operation should not fall under water. For some problems, you can unscrew it and press the balloon several times with your fingers. After the inhaler should start working in the usual mode.

Keep in mind that even an empty bottle should be kept away from children. It cannot be thrown, crushed, pierced or otherwise manipulated. When cooled, the drug acts somewhat more slowly than usual. Therefore, it is not recommended to keep it in the refrigerator.

GCS for inhalation

Active substance

Release form, composition and packaging

Excipients: hydrofluoroalkane (HFA-134a) - 75.86 mg, ethanol - 2.09 mg.

Aerosol for inhalation dosed, breath-activated, in the form of a solution which, when sprayed onto glass, forms a colorless spot.

Excipients: hydrofluoroalkane (HFA-134a) - 74.79 mg, ethanol - 3.11 mg.

200 doses - aluminum cylinders (1) - breath-activated aerosol inhalers (Easy Breathing) (1) - cardboard packs.

Aerosol for inhalation dosed, breath-activated, in the form of a solution which, when sprayed onto glass, forms a colorless spot.

Excipients: hydrofluoroalkane (HFA-134a) - 71.75 mg, ethanol - 6 mg.

200 doses - aluminum cylinders (1) - breath-activated aerosol inhalers (Easy Breathing) (1) - cardboard packs.

pharmachologic effect

GCS for inhalation use. Beclomethasone dipropionate is a prodrug and has a weak tropism for GCS receptors. Under the action of esterases, it turns into an active metabolite - beclomethasone-17-monopropionate (B-17-MP), which has a pronounced local anti-inflammatory effect. It reduces inflammation by reducing the formation of chemotaxis substance (influence on "late" allergy reactions), inhibits the development of an immediate allergic reaction (due to inhibition of the production of arachidonic acid metabolites and a decrease in the release of inflammatory mediators from mast cells) and improves mucociliary transport. Under the action of beclomethasone, the number of mast cells in the bronchial mucosa decreases, epithelial edema decreases, mucus secretion by bronchial glands, bronchial hyperreactivity, marginal accumulation of neutrophils, inflammatory exudate and production of lymphokines, macrophage migration is inhibited, and the intensity of infiltration and granulation processes decreases.

Increases the number of active β-adrenergic receptors, restores the patient's response to bronchodilators, and reduces the frequency of their use. Virtually no resorptive effect after inhalation.

Does not stop bronchospasm, the therapeutic effect develops gradually, usually after 5-7 days of course use of beclomethasone dipropionate.

Pharmacokinetics

Suction

After inhalation, up to 56% of the dose of the drug settles in the lower respiratory tract; the remaining amount settles in the mouth, pharynx and is swallowed. In the lungs, before the absorption of beclomethasone, dipropionate is extensively metabolized to the active metabolite B-17-MP. Systemic absorption of B-17-MP occurs in the lungs (36% of the lung fraction), in the gastrointestinal tract (26% of the dose received here when swallowed). The absolute bioavailability of unchanged beclomethasone dipropionate and B-17-MP is about 2% and 62% of the inhalation dose, respectively. Beclomethasone dipropionate is rapidly absorbed, Cmax is reached after 0.3 hours. B-17-MP is absorbed more slowly, Cmax is reached after 1 hour. There is an approximately linear relationship between increasing dose and systemic exposure of the drug.

Distribution

V d is 20 liters for beclomethasone dipropionate and 424 liters for B-17-MP. Binding to blood proteins is relatively high - 87%.

breeding

Beclomethasone dipropionate and B-17-MP have high plasma clearance (150 l/h and 120 l/h, respectively). T 1/2 is 0.5 h and 2.7 h, respectively.

Indications

Contraindications

— childhood up to 4 years;

- Hypersensitivity to the components of the drug.

Dosage

Beclazone Eco Easy Breathing is for inhalation use only.

Beclazone Eco Easy Breathing is used regularly (even in the absence of symptoms of the disease), the dose of beclomethasone dipropionate is selected taking into account the clinical effect in each case.

With a mild course of bronchial asthma, the forced expiratory volume (FEV 1) or peak expiratory flow rate (PSV) is more than 80% of the proper values with a spread in PSV values of less than 20%.

With a moderate course of FEV 1 or PSV is 60-80% of the proper values, the daily variation in PSV is 20-30%.

In severe cases, FEV 1 or PSV is 60% of the expected values, the daily variation in PSV is more than 30%.

When switching to a high dose of inhaled beclomethasone dipropionate in many patients receiving systemic corticosteroids, their dose can be reduced or completely canceled.

The initial dose Easy Breathing is determined by the severity of bronchial asthma. The daily dose is divided into several doses.

Depending on the individual response of the patient, the dose of the drug can be increased until a clinical effect appears or reduced to the minimum effective dose.

Adults and children aged 12 and over recommended initial doses of the drug for mild bronchial asthma make up 200-600 mcg / day; at moderate bronchial asthma- 600-1000 mcg / day; at severe bronchial asthma- 1000-2000 mcg / day.

Children aged 4 to 12 the dose of the drug is up to 400 mcg / day in several doses.

There is no need to adjust the dose of Beclazone Eco Easy Breathing in the elderly, in patients with renal or hepatic insufficiency.

At accidental skipping of inhalation the next dose must be taken at the appropriate time in accordance with the treatment regimen.

Beclazone Eco Easy Breathing containing 250 mcg of beclomethasone in 1 dose is not intended for use in pediatrics.

Instructions for using the inhaler

Holding the inhaler upright, open the lid. Take a deep breath. Close the mouthpiece tightly with your lips. Make sure that the hand does not block the ventilation holes on the top of the inhaler, and the inhaler is in an upright position. Take a slow maximum breath through the mouthpiece. Hold your breath for 10 seconds or as long as possible. Then you should remove the inhaler from the mouth and exhale slowly. After use, keep the inhaler in an upright position. Close the lid. If more than one inhalation is necessary, close the lid, wait at least 1 minute, and then repeat the inhalation process.

Cleaning the inhaler

Unscrew the top of the inhaler. Pull out the metal can. Rinse the bottom of the inhaler in warm water and dry. Insert the bottle into place. Close the lid and screw the top of the inhaler to its body. Do not wash the top of the inhaler. If the inhaler does not work properly, unscrew its top and manually press the can.

Side effects

Local reactions: possible candidiasis of the mouth and throat (the likelihood of developing candidiasis increases with the use of beclomethasone dipropionate in doses exceeding 400 mcg / day), dysphonia (hoarseness) or irritation of the pharyngeal mucosa.

From the side respiratory system: paradoxical bronchospasm is possible, which must be immediately stopped with an inhaled beta 2 short-acting adrenostimulator.

Allergic reactions: rash, urticaria, itching, redness and swelling of the eyes, face, lips and mucous membranes of the mouth and pharynx are possible.

Effects due to systemic action: include headache, nausea, bruising or thinning of the skin, unpleasant taste sensations, decreased function of the adrenal cortex, osteoporosis, growth retardation in children and adolescents, cataracts, glaucoma.

Overdose

Acute overdose can lead to a temporary decrease in the function of the adrenal cortex, which does not require emergency therapy, because. function of the adrenal cortex is restored within a few days, as evidenced by plasma cortisol levels.

At chronic overdose there may be persistent suppression of the function of the adrenal cortex.

In such cases, it is recommended to monitor the reserve function of the adrenal cortex. In case of overdose, treatment with beclomethasone dipropionate may be continued at doses sufficient to maintain the therapeutic effect.

drug interaction

There are no confirmed data on the interaction of beclomethasone dipropionate with other medicines.

special instructions

Before prescribing inhaled corticosteroids, it is necessary to instruct the patient about the rules for their use, which ensure the most complete entry of the drug into the desired areas of the lungs. Development of candidiasis oral cavity most likely in patients with high levels of precipitating antibodies in the blood against the Candida fungus, indicating a previous fungal infection. After inhalation, rinse the mouth and throat with water. For the treatment of candidiasis, topical antifungal drugs can be used while continuing therapy with Beclazone Eco Easy Breathing.

If patients take corticosteroids orally, then Beclazon Eco Easy Breathing is prescribed while taking the previous dose of corticosteroids, while patients should be in a relatively stable condition. Approximately 1-2 weeks later daily dose oral corticosteroids begin to gradually decrease. The dose reduction scheme depends on the duration of previous therapy and on the initial dose of GCS. Regular use of inhaled corticosteroids allows in most cases to cancel oral corticosteroids (patients who need to take no more than 15 mg can be completely transferred to inhalation therapy), while in the first months after the transition, the patient's condition should be carefully monitored until his pituitary-adrenal system will not recover sufficiently to respond adequately to stressful situations (such as injury, surgery, or infection).

When transferring patients from taking systemic corticosteroids to inhaled therapy, allergic reactions may occur (for example, allergic rhinitis, eczema), which were previously suppressed by systemic drugs.

Patients with reduced function of the adrenal cortex, transferred to inhalation treatment, should have a supply of corticosteroids and always carry a warning card with them, which should indicate that they need additional systemic administration of corticosteroids in stressful situations (after eliminating the stressful situation, the dose of corticosteroids can be taken again reduce). Sudden and progressive worsening of asthma symptoms is a potentially dangerous condition, often life-threatening for patients, and requires an increase in the dose of corticosteroids. An indirect indicator of therapy failure is the more frequent use of short-acting beta2-adrenergic stimulants than before.

Beclazon Eco Easy Breathing is not intended for stopping seizures, but for regular daily use. Short-acting beta 2-adrenergic stimulants (for example,) are used to stop seizures. In case of severe exacerbation of bronchial asthma or insufficient effectiveness of the therapy, the dose of Beclazone Eco Easy Breathing should be increased and, if necessary, systemic corticosteroids and / or an antibiotic should be prescribed if the infection develops.

With the development of paradoxical bronchospasm, you should immediately stop using Beclazone Eco Easy Breathing, assess the patient's condition, conduct an examination and, if necessary, prescribe therapy with other drugs.

With prolonged use of any inhaled corticosteroids, especially at high doses, systemic effects may be observed, but the likelihood of their development is much lower than when taking corticosteroids orally. Therefore, it is especially important that when a therapeutic effect is achieved, the dose of inhaled corticosteroids should be reduced to the minimum effective dose that controls the course of the disease. At a dose of 1500 mcg / day, the drug in most patients does not cause significant suppression of adrenal function. In connection with possible development adrenal insufficiency, special care should be taken and the indicators of the function of the adrenal cortex should be regularly monitored when transferring patients taking oral corticosteroids to treatment with Beclazone Eco Easy Breathing.

Special care should be taken when treating patients with active or inactive forms of pulmonary tuberculosis with inhaled corticosteroids.

It is necessary to protect the eyes from getting the drug. Washing after inhalation can prevent damage to the skin of the eyelids and nose.

A can of Beclazone Eco Easy Breath must not be pierced, disassembled or thrown into fire, even if it is empty. Like most other aerosol inhalers, Beclazone Eco Easy Breath may be less effective at low temperatures. When cooling the cartridge, it is recommended to remove it from the plastic case and warm it with your hands for several minutes.

Pediatric use

For impaired liver function

There is no need to adjust the dose of Beclazone Eco Easy Breathing in patients with hepatic insufficiency.

FROM caution used in cirrhosis of the liver.

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Terms and conditions of storage

The drug should be stored out of the reach of children, protected from direct sunlight at a temperature not exceeding 25 ° C; do not freeze. Shelf life - 3 years.

Instructions for use

Beclazon Eco instructions for use

Dosage form

Aerosol for inhalation in a pressurized aluminum can. There must be no external damage, corrosion or leakage.

The contents of the can leave a white spot when sprayed onto glass.

Composition

Each inhaler contains 200 doses of the drug.

Each dose of the drug contains:

Active substance: beclomethasone dipropionate 100.0 mcg;

Excipients: hydrofluoroalkane (HFA-134a) 74.79 mg; ethanol 3.11 mg.

Pharmacodynamics

Beclomethasone is a glucocorticosteroid (GCS) and has a weak affinity for GCS receptors. Under the action of enzymes, it turns into an active metabolite - beclomethasone-17-monopropionate (B-17-MP), which has a pronounced local anti-inflammatory effect. It reduces inflammation by reducing the formation of chemotaxis substance (influence on "late" allergy reactions), inhibits the development of an "immediate" allergic reaction (due to inhibition of the production of arachidonic acid metabolites and a decrease in the release of inflammatory mediators from mast cells) and improves mucociliary transport. Under the action of beclomethasone, the number of mast cells in the bronchial mucosa decreases, epithelial edema decreases, mucus secretion by bronchial glands, bronchial hyperreactivity, marginal accumulation of neutrophils, inflammatory exudate and production of lymphokines, macrophage migration is inhibited, and the intensity of infiltration and granulation processes decreases. Increases the number of active beta-adrenergic receptors, restores the patient's response to bronchodilators, and reduces the frequency of their use. Virtually no resorptive effect after inhalation.

Does not stop bronchospasm, the therapeutic effect develops gradually, usually after 5-7 days of course use of beclomethasone.

Pharmacokinetics

More than 25% of the dose of inhaled beclomethasone is deposited in respiratory tract; the remaining amount settles in the mouth, pharynx and is swallowed. In the lungs, before absorption, beclomethasone is extensively metabolized to the active metabolite B-17-MP. Systemic absorption of B-17-MP occurs in the lungs (36% of the lung fraction), in gastrointestinal tract(26% of the dose delivered here by ingestion). The absolute bioavailability of unchanged beclomethasone and B-17-MP is about 2% and 62% of the inhaled dose, respectively. Beclomethasone is rapidly absorbed, the time to reach maximum plasma concentration (Tmax) is 0.3 hours. B-17-MP is absorbed more slowly, Tmax is 1 hour. There is an approximately linear relationship between an increase in inhaled dose and systemic exposure to beclomethasone.

Distribution in tissues is 20 liters for beclomethasone and 424 liters for B-17-MP. Communication with blood plasma proteins is relatively high - 87%.

Beclomethasone and B-17-MP have high plasma clearance (150 l/h and 120 l/h, respectively). The half-life is 0.5 h and 2.7 h, respectively.

Side effects

The incidence of side effects is classified according to the recommendations of the World Health Organization: very often - at least 10%; often - not less than 1%, but less than 10%; infrequently - not less than 0.1%, but less than 1%; rarely - not less than 0.01%, but less than 0.1%; very rarely (including isolated cases) - less than 0.01%.

Infectious diseases: often - candidiasis of the oral cavity and upper respiratory tract and pharynx (with prolonged use in high doses of more than 400 mcg per day).

Allergic reactions: rarely - skin rash, pruritus, urticaria, erythema, angioedema, including swelling of the paraorbital region, mucous membrane of the oral cavity and pharynx, lips and face.

From the side endocrine system: very rarely - inhibition of the hypothalamic-pituitary-adrenal system (HPA) (with prolonged use of high doses of more than 1.5 g / day), including growth retardation in children.

On the part of the organ of vision: very rarely - cataracts, glaucoma.

From the respiratory system, organs chest and mediastinum: often - hoarseness, irritation of the mucous membrane of the pharynx (the use of a spacer reduces the likelihood of developing these side effects); rarely - paradoxical bronchospasm (stopped with short-acting inhaled beta2-agonists); very rarely zoeinophilic pneumonia.

On the part of the musculoskeletal and connective tissue: very rarely, a decrease in bone mineral density.

Effects due to systemic action: headache, nausea; bruising or thinning of the skin.

Selling Features

prescription

Special storage conditions

Do not freeze.

Special conditions

Before using the drug Beclazon Eco, it is necessary to make sure that the patient uses the inhalation device correctly to ensure sufficient dosing of the drug.

Patients using Beclazon Eco at home should be warned that if the effect of the usual dose becomes less effective or less prolonged, you should not independently increase the dose or frequency of use of the drug, and you should immediately consult a doctor.

With prolonged use of beclomethasone in high doses (more than 400 mcg / day), candidiasis of the oral cavity and pharynx develops, especially in patients who have previously had a fungal infection, which is confirmed by a high blood level of precipitating antibodies against Candida fungi. As a rule, the use of antifungal drugs contributes to the rapid elimination of a fungal infection. The dose of beclomethasone should not be changed in this case.

If treatment with inhaled beclomethasone begins against the background of ingestion of corticosteroids, then a reduction in the dose of corticosteroids can be started only 1-2 weeks after the start of simultaneous use. The scheme for reducing the dose of corticosteroids for oral administration depends on the dose and duration of the use of corticosteroids. Regular use of inhaled beclomethasone in most cases allows you to reduce the dose of corticosteroids for oral administration. As a rule, patients taking no more than 15 mg of prednisolone can completely switch to inhaled beclomethasone alone. The first months after switching to inhaled therapy with beclomethasone, it is necessary to carefully monitor the state of the HPA to prevent its suppression.

Patients with reduced adrenal function switched fully to treatment with inhaled beclomethasone should always carry a supply of corticosteroids with them and carry a warning card with information that they need to use systemic corticosteroids in stressful situations. After the end of the stressful situation, the dose of corticosteroids can be reduced or corticosteroids can be canceled.

An increase in the dose of corticosteroids is required with a sudden and progressive worsening of the course of bronchial asthma. An indirect indicator of therapy failure is the more frequent use of short-acting beta2-agonists.

When transferring patients from oral GCS to inhaled GCS, including beclomethasone, various allergic reactions may occur, including allergic rhinitis and allergic dermatitis, which did not appear during treatment with systemic GCS.

Beclomethasone for inhalation is intended for regular daily use, and not for stopping attacks of bronchospasm. To stop attacks of bronchospasm, beta2-adronomimetics, including salbutamol, are used. In case of severe bronchial asthma or insufficient effectiveness of inhaled beclomethasone, it is necessary to increase its dose, and also consider the use of corticosteroids orally or, for example, the use of antibiotics in case of infectious inflammation.

With the development of paradoxical bronchospasm, beclomethasone should be discontinued, the patient should be examined and the possibility of using another drug should be considered.

Do not abruptly stop treatment with inhaled beclomethasone,

With prolonged use of inhaled beclomethasone at a dose of more than 1.5 g / day, systemic reactions of a different nature may develop, including symptoms of suppression of the function of the adrenal cortex, a decrease in the growth rate in children, a decrease in bone mineral density, cataracts, glaucoma. Therefore, when a therapeutic effect is achieved, the dose of inhaled beclomethasone should be reduced to the minimum effective dose that controls the course of the disease. Patients at high risk of developing adrenal insufficiency should be under medical supervision.

With prolonged use of beclomethasone in children, it is necessary to control the dynamics of their growth.

Caution should be exercised when using inhaled corticosteroids in patients with active and inactive forms of pulmonary tuberculosis.

It is necessary to protect the eyes from getting the drug Beclazon Eco.

An aluminum can with Beclazone Eco should not be pierced, disassembled or heated, even if it is empty.

Impact on ability to drive vehicles and other mechanisms:

Beclomethasone inhalations do not affect driving and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Indications

Basic therapy of various forms of bronchial asthma in adults and children over 4 years of age.

Contraindications

Hypersensitivity to beclomethasone and other components of the drug; children's age up to 4 years.

Carefully:

Pregnancy and lactation:

With extreme caution, Beclazon Eco should be used during pregnancy and during breastfeeding only if the expected benefit to the mother outweighs the possible risk to the fetus and infant.

drug interaction

Beclomethasone restores the patient's response to beta-agonists, allowing to reduce the frequency of their use. With simultaneous use with phenobarbital, phenytoin, rifampicin and other inducers of microsomal liver enzymes, the effectiveness of beclomethasone is reduced. With simultaneous use with methandienone, estrogens, beta2-agonists, theophylline, as well as systemic corticosteroids, the effectiveness of beclomethasone increases. With the simultaneous use of beclomethasone enhances the effect of beta-agonists.

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Mode of application

Dosage

ATTENTION!!! Beclazone Eco is activated by PRESSING the inhalation device.

The drug Beclazone Eco is intended for inhalation administration using an inhalation device (see "Instructions for the patient on the use of an inhalation device"). After each inhalation, thoroughly rinse the mouth and throat with water.

Apply regularly (even in the absence of symptoms of the disease). The dose is selected taking into account individual clinical effectiveness, increasing until the appearance of a clinical effect or reducing to the minimum effective dose. When switching to a high dose of inhaled beclomethasone, many patients receiving systemic corticosteroids will be able to reduce their dose or stop them altogether.

The initial dose is determined by the severity of bronchial asthma. With a mild course of bronchial asthma, the forced expiratory volume (FEV) or peak expiratory flow rate (PSV) is more than 80% of the proper values with a spread in PSV values of less than 20%. In moderate course of bronchial asthma, FEV or PSV is 60-80% of the proper values, the daily variation of PSV values is 20-30%. In severe bronchial asthma, FEV or PSV are less than 60% of the proper values, the daily variation in PSV values is more than 30%. The daily dose is divided into several doses (2-4 inhalations per day).

Adults and children aged 12 and over

Bronchial asthma of a mild course - 200-600 mcg / day (for 2 inhalations per day);

Bronchial asthma of moderate course - 600-1000 mcg / day (for 2-4 inhalations per day);

Bronchial asthma of severe course - 1000-2000 mcg / day (for 2-4 inhalations per day).

The standard maximum daily dose is 1000 mcg. In some very severe cases, the daily dose can be increased to 1500-2000 mcg (for 2-4 inhalations per day).

The treatment of bronchial asthma is based on stepwise approach- therapy is started according to the stage corresponding to the severity of the disease. Inhaled corticosteroids are prescribed at the second stage of therapy.

Stage 2. Basic therapy. 100-400 mcg 2 times a day.

Stage 3. Basic therapy. Inhaled corticosteroids are used in a high daily dose or in a standard daily dose, but in combination with long-acting inhaled beta2-agonists. The recommended daily dose is 800-1600 mcg, in some cases the daily dose can be increased to 2000 mcg.

Stage 4. Severe bronchial asthma. The recommended daily dose is 800-1600 mcg, in some cases the daily dose can be increased to 2000 mcg. Stage 5. Severe bronchial asthma. The recommended daily dose is 800-1600 mcg, in some cases the daily dose can be increased to 2000 mcg.

Children aged 4 to 12

The recommended initial daily dose is 100-200 mcg (for 2 inhalations per day). The standard maximum daily dose is 200 mcg. In some very severe cases, the daily dose can be increased to 400 mcg (for 2-4 inhalations per day).

The drug Beclazone Eco, containing 250 mcg of beclomethasone in 1 dose, is not intended for use in this group of patients.

Special patient groups

There is no need to adjust the dose in the elderly, in patients with renal or hepatic insufficiency.

Missing one dose of the drug

In case of accidental skipping of inhalation, the next dose should be taken at the appropriate time in accordance with the treatment regimen. The introduction can be carried out using special dispensers (spacers), which improve the distribution of the drug in the lungs and reduce the risk of side effects.

Instructions for the patient to use the inhalation device

Before using the inhalation device for the first time, or if you have not used it for some time, it is necessary to check its serviceability by pressing the can valve and releasing a dose of medicine into the air.

1. Remove the protective cap from the inhalation device and make sure that the outlet tube of the inhalation device is clean. Hold the inhalation device between your index finger and thumb in an upright position while thumb should be located on the bottom of the inhalation device, and the index finger on the top of the aluminum cylinder.

2. Shake the aluminum can vigorously up and down.

3. Breathe out deeply through your mouth. Close the outlet tube of the inhalation device tightly with your lips.

4. Take a slow and deep breath. At the moment of inhalation, press the dosing valve of the balloon with your index finger, releasing the dose of Beclazone Eco, continue to inhale slowly.

5. Remove the inhalation device from your mouth and hold your breath for 10 seconds or as long as you feel comfortable. Exhale slowly.

6. After inhalation, rinse your mouth with water, being careful not to swallow the aerosol that got on the oral mucosa during inhalation.

7. If more than one dose of the drug is required, wait 1 minute and repeat all steps from step 2 to step 6.

8. Close the inhalation device with a protective cap. When performing steps 3 and 4, take your time.

At the moment of releasing the vine of the medicine, it is important to inhale as slowly as possible. Practice in front of a mirror before use. If you notice "steam" coming out of the top of the can or from the corners of your mouth, start again from step 2.

Cleaning the inhaler

The inhalation device should be cleaned at least once a week. Remove the aluminum canister from the inhalation device. Gently rinse the inhalation device and protective cap with warm water. Hot water must not be used! Shake the inhalation device and protective cap to remove residual water and dry them without using heating devices. The aluminum cylinder must not be allowed to come into contact with water!

Overdose

An acute overdose of the drug may occur when inhaling a high single dose of more than 1 g. The manifestation, in this case, of symptoms of suppression of the function of the adrenal cortex does not require emergency therapy, since the function is restored within a few days, which is confirmed by plasma cortisol levels.

In chronic overdose ( long-term treatment a dose of more than 1.5 g) there may be a persistent suppression of the function of the adrenal cortex. In such cases, it is recommended to monitor the reserve function of the adrenal cortex. In case of overdose, treatment with beclomethasone may be continued at doses sufficient to maintain the therapeutic effect.

Aerosol for inhalation in a pressurized aluminum can.

There must be no external damage, cracks, corrosion or leakage. The contents of the can are a white suspension. When spraying the drug on the glass, a white spot remains.

Pharmacotherapeutic group

Other inhaled drugs for the treatment of obstructive airways disease. Glucocorticosteroids.

ATX code R03BA01

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Pharmacological properties

Pharmacokinetics

More than 25% of the dose of the inhaled drug is deposited in the respiratory tract; the remaining amount settles in the mouth, pharynx and is swallowed. In the lungs, before the absorption of beclomethasone, dipropionate is extensively metabolized to the active metabolite B-17-MP. Systemic absorption of B-17-MP occurs in the lungs (36% of the lung fraction) in the gastrointestinal tract (26% of the ingested dose received here) The absolute bioavailability of unchanged beclomethasone dipropionate and B-17-MP is about 2% and 62%, respectively from the inhalation dose. Beclamethasone dipropionate is rapidly absorbed, the time to reach maximum plasma concentration (Tmax) is 0.3 hours. B-17-MP is absorbed more slowly, Tmax is 1 hour. There is an approximately linear relationship between an increase in inhaled dose and systemic exposure of the drug.

Distribution in tissues is 20 liters for beclazone dipropionate and 424 liters for B-17-MP. Communication with blood plasma proteins is relatively high - 87%.

Beclamethasone dipropionate and B-17-MP have high plasma clearance (150 l/h and 120 l/h, respectively). The half-life is 0.5 hours and 2.7 hours, respectively.

Pharmacodynamics

Beclamethasone dipropionate is a prodrug and has a weak affinity for GCS receptors. Under the action of esterases, it is converted into an active metabolite - beclomethasone-17-monopropionate (B-17-MP), which has a pronounced local anti-inflammatory effect. Reduces inflammation by reducing the formation of chemotaxis substance (influence on "late" allergy reactions), inhibits the development of an "immediate" allergic reaction (due to inhibition of the production of arachidonic acid metabolites and a decrease in the release of inflammatory mediators from mast cells) and improves mucociliary transport. Under the action of beclomethasone, the number of mast cells in the bronchial mucosa decreases, epithelial edema decreases, mucus secretion by bronchial glands, bronchial hyperreactivity, marginal accumulation of neutrophils, inflammatory exudate and production of lymphokines, macrophage migration is inhibited, and the intensity of infiltration and granulation processes decreases. Increases the number of active beta-adrenergic receptors, restores the patient's response to bronchodilators, and reduces the frequency of their use. Virtually no resorptive effect after inhalation.

Does not stop bronchospasm, the therapeutic effect develops gradually, usually after 5-7 days of course use of beclomethasone dipropionate.

Indications for use

Bronchial asthma of various forms in adults and children over 4 years of age

Dosage and administration

Beclazone Eco is intended for inhalation only.

Beclazone Eco is used regularly (even in the absence of symptoms of the disease), the dose of beclomethasone dipropionate is selected taking into account the clinical effect in each case.

With a mild course of bronchial asthma, the forced expiratory volume (FEV) or peak expiratory flow rate (PSV) is more than 80% of the proper values with a spread in PSV values of less than 20%.

With a moderate course of FEV or PSV is 60-80% of the proper values, the daily variation in PSV is 20-30%.

In severe cases, FEV or PSV are 60% of the proper values, the daily variation in PSV is more than 30%.

When switching to a high dose of inhaled beclamethasone dipropionate, many patients receiving systemic glucocorticosteroids will be able to reduce their dose or stop them altogether.

The initial dose of Beclazone Eco is determined by the severity of bronchial asthma. The daily dose is divided into several doses.

Depending on the individual response of the patient, the dose of the drug can be increased until a clinical effect appears or reduced to the minimum effective dose.

Adults and children aged 12 and over:

mild bronchial asthma - 200-600 mcg / day

Bronchial asthma of moderate course - 600-1000 mcg / day

severe bronchial asthma - 1000-2000 mcg / day

The treatment of bronchial asthma is based on a stepwise approach - therapy is started according to the step corresponding to the severity of the disease.

Inhaled corticosteroids are prescribed at the second stage of therapy.

Stage 2. Basic therapy.

Beclamethasone dipropionate 100-400 mcg 2 times a day.

Stage 3. Basic therapy.

Inhaled corticosteroids are used in a high dose or in a standard dose, but in combination with long-acting inhaled β-2-adrenergic antagonists.

Beclomethasone dipropionate in a high dose - 800-1600 mcg / day, in some cases, megadoses up to 2000 mcg / day.

Stage 4. Severe asthma.

Beclomethasone dipropionate in a high dose of 800-1600 mcg / day, in some cases, megadoses up to 2000 mcg / day.

Stage 5. Severe asthma.

High dose beclamethasone dipropionate (see step 3.4)

Children aged 4 to 12

Up to 400 mcg per day in divided doses.

Special patient groups

There is no need to adjust the dose of Beclazone Eco in the elderly, in patients with renal or hepatic insufficiency.

Missing one dose of the drug

In case of accidental skipping of inhalation, the next dose should be taken at the appropriate time in accordance with the treatment regimen.

A course of treatment

Individual

Side effects

Some patients may develop candidiasis of the mouth and throat (the likelihood of developing candidiasis increases with the use of beclamethasone dipropionate in doses exceeding 400 mcg per day).

Some patients may experience dysphonia (hoarseness) or irritation of the pharyngeal mucosa. The use of a spacer reduces the likelihood of these side effects.

Inhaled drugs can cause paradoxical bronchospasm, which must be immediately treated with a short-acting inhaled b-2-agonist. Hypersensitivity reactions have been reported, including rash, urticaria, itching, redness, and swelling of the eyes, face, lips, and oral and pharyngeal mucosa .Possible systemic effects include headache, nausea, bruising or thinning of the skin, unpleasant taste sensations, decreased function of the adrenal cortex, osteoporosis, growth retardation in children and adolescents, cataracts, glaucoma.

Contraindications

Hypersensitivity to any component of the drug

Children's age up to 4 years

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Drug Interactions

Not installed.

special instructions

Before prescribing inhalation drugs, it is necessary to instruct the patient about the rules for their use, ensuring the most complete entry of the drug into the desired areas of the lungs. The development of oral candidiasis is most likely in patients with a high level of precipitating antibodies in the blood against the Candida fungus, which indicates a previous fungal infection. After inhalation, rinse the mouth and throat with water. For the treatment of candidiasis, topical antifungal drugs can be used while continuing therapy with Beclazone Eco.

If patients take corticosteroids orally, then Beclazon Eco is prescribed while taking the previous dose of corticosteroids, while patients should be in a relatively stable condition. After about 1-2 weeks, the daily dose of oral corticosteroids begins to be gradually reduced. The dose reduction scheme depends on the duration of previous therapy and on the initial dose of GCS. Regular use of inhaled corticosteroids allows in most cases to cancel oral corticosteroids (patients who need to take no more than 15 mg of prednisolone can be completely transferred to inhalation therapy), while in the first months after the transition, the patient's condition should be carefully monitored until his pituitary-adrenal the system will not recover sufficiently to provide an adequate response to stressful situations (for example, trauma, surgery, or infection).

When transferring patients from taking systemic corticosteroids to inhaled therapy, allergic reactions (eg, allergic rhinitis, eczema), which were previously suppressed by systemic drugs, may occur.

Beclazon Eco is not intended for stopping seizures, but for regular daily use. Short-acting b-2-adrenergic stimulants (for example, salbutamol) are used to stop seizures. In case of severe exacerbation of bronchial asthma or insufficient effectiveness of the therapy, the dose of inhaled beclomethasone dipropionate should be increased and, if necessary, systemic corticosteroids and / or an antibiotic should be prescribed if the infection develops.

With the development of paradoxical bronchospasm, you should immediately stop using Beclazone Eco, assess the patient's condition, conduct an examination and, if necessary, prescribe therapy with other drugs. With prolonged use of any inhaled corticosteroids, especially at high doses, systemic effects may occur (see " Side effects”), however, the likelihood of their development is much lower than when taking GCS orally. Therefore, it is especially important that when a therapeutic effect is achieved, the dose of inhaled corticosteroids should be reduced to the minimum effective dose that controls the course of the disease. At a dose of 1500 mcg / day, the drug in most patients does not cause significant suppression of adrenal function. In connection with the possible adrenal insufficiency, special care should be taken and the indicators of the function of the adrenal cortex should be regularly monitored when transferring patients taking GCS orally to treatment with Beclazone Eco.

Latin name: Beclazone Eco Easy Breath
ATX code: R03B A01
Active substance: Beclometasone
Manufacturer: Norton (Ireland), Teva
Pharmaceutical Industries (Israel)
Vacation from the pharmacy: on prescription
Storage conditions: t up to 30 °С
Best before date: 3 years

Indications for use

Beclazone Eco Easy Breath is hormonal drug. It is intended for preventive therapy of chronic bronchial asthma, occurring with varying degrees of severity, and other obstructive respiratory diseases.

Composition and form of release

International non-proprietary name for inhaled drugs: Beclomethasone.

The medicine is produced in the form of an aerosol for dosed inhalation. Activated by inhalation. Produced with different concentrations of the active ingredient beclamethasone:

Aerosol with 50 mcg per dose

Auxiliary components: hydrofluoroalkane - 75.8 mg, 2.09 mg of alcohol

Aerosol with 100 mcg per dose

Auxiliary components: 74.79 mg of hydrofluoroalkane, 3.1 mg of ethanol.

Aerosol with 250 mcg per dose

Auxiliary components: 71.7 mg of hydrofluoroalkane, 6 mg of alcohol.

The medicine is presented as clear liquid smelling of alcohol. Each type of drug is designed for 200 doses. The product is contained in a container (cartridge) under pressure made of aluminum, enclosed in an inhalation device, which consists of two parts and a lid. Packed with accompanying manual in carton packs.

Medicinal properties

The therapeutic effect of Beclazone is achieved due to the properties inherent in the main component of the inhalation solution. Beclomethasone in the form of dipropionate belongs to the group of prodrugs: it acquires medicinal properties after penetration into the body, transforming into an active metabolite under the influence of esterase enzymes. The new compound has anti-inflammatory properties at the sites of settling.

Due to the effect of the substance, the content of mast cells in bronchial tissues is reduced, swelling of the epithelium is removed, the amount of mucus formed in the bronchi decreases, and the intensity of inflammatory processes decreases. At the same time, the number of beta receptors responsible for the expansion of the bronchi increases, and sensitivity to drugs is also restored.

Inhalation drugs do not have the ability to stop bronchospasm. The effect of the application develops gradually with systematic use - usually within a week.

After inhalation, the substance is distributed in the respiratory tract: more than half of the dose (about 57%) settles in the lower sections, a certain amount remains in the oral cavity and pharynx, some is swallowed. After penetration into the body, beclamethasone is absorbed at a high rate. Top performance concentrations are formed already 20 minutes after the procedure.

The drug is excreted from the body mainly with feces, a small part - with urine.

Mode of application

Average cost: ing. (0.05 mg / dose) - 228 rubles, (0.1 mg / dose) - 643 rubles, (0.25 mg / dose) - 1084 rubles.

Beclazone Eco Easy Breathing should only be used by inhalation. It should be used regularly throughout the course, even if the patient feels normal, and no manifestations of the disease bother him.

The dosage and duration of the course are determined individually for each patient, based on his indications. daily rate Beclazone is divided into several procedures.

For children from 4 to 12 years old - 400 mcg

For adults and children from 12 years of age, depending on the course of asthma:

Lung: 200 to 600 micrograms
Medium: 600 to 1000 mcg
Severe: 1000 mcg to 2000.

The dosage of Beclazone Eco Easy Breathing for aged patients, patients with insufficient functioning of the liver or kidneys is prescribed on a general basis. No correction required.

During pregnancy and HB

The drug is not allowed to be used by pregnant women in the first term of gestation. The appointment of Beclazone is possible in the following months, but only after a thorough examination, and also if the benefit to the mother outweighs the risk of threats to the fetus. If a woman was treated with inhalations for recent weeks gestation, then the newborn child needs to check the condition of the adrenal glands.

Breastfeeding women should refrain from using beclomethasone inhaler, as it is not known whether the substance passes into milk and how dangerous it is for babies.

Contraindications and precautions

Inhaler Beclazon Eco Light Breathing is prohibited for:

Individual hypersensitivity to drug ingredients
Severe course of bronchial asthma, attacks
Tuberculosis
Candidiasis and fungal infection upper respiratory tract
First trimester of pregnancy
Age up to 4 years.

The drug can be prescribed with caution when:

Glaucoma
Systemic infections of any origin
Osteoporosis
Pulmonary tuberculosis
Cirrhosis of the liver
Decreased levels of thyroid hormones in the body
Carrying a child and GV.

When prescribing Beclazone, the doctor must proceed from the patient's condition and the proportionality of benefits and harms and take control of the course of therapy.

special instructions

During the appointment of the medication Beclazon Eco Easy Breathing, the patient should be familiar with the features of the operation of the inhaler, so that during the procedure the drug is guaranteed to penetrate into certain areas of the lungs.

The occurrence of candidiasis in the oral cavity is most susceptible to patients with a high concentration of precipitins in the blood, which is evidence of a previous infectious disease.

If the patient is taking oral corticosteroids, then Beclazon-Eco is recommended to be used at the appropriate dose. Provided that the patient's condition is stable. Approximately 1-2 weeks later, the dosage of GCS in tablets is gradually reduced. The reduction scheme is determined by the doctor, depending on the duration of the previous course and the magnitude of the initial dose of drugs. Systematic therapy of corticosteroids in the form of inhalations allows you to abandon oral medications. After the abolition of GCS, the patient's condition should be monitored for at least 3 months, that is, until the pituitary-adrenal system is fully restored.

The transition from oral to inhaled GCS can provoke severe allergic symptoms, which were previously blocked by GCS tablets. Therefore, at the beginning of adaptation, it is advisable for patients to always have spare GCS tablets with them and a note with a warning that in a stressful situation they need to drink this drug.

Unexpected and increased manifestations of asthma can be life-threatening, and therefore high doses of corticosteroids are needed to stop them. It is possible to judge the inefficiency of the previous treatment by the increased use of β-2-adrenergic stimulants.

The drug Beclazon Eco LD is not intended for emergency relief of asthma attacks, its therapeutic effect develops with daily systematic use.

If asthma is severe, this is the reason for increasing the dosage of inhaled medication, prescribing oral corticosteroids or antibiotics (if there is an infection).

In the event of the development of bronchospasm, it is necessary to immediately cancel the use of Beclazone, conduct an examination of the patient and make changes to the treatment regimen.

Long-term therapy with any inhaled corticosteroids can lead to systemic disorders. Although this form of the drug provokes less complications than oral drugs, after the stabilization of the patient's condition, it is necessary to reduce the dosage to the minimum at which the course of the disease can be controlled.

If Beclazone is used for a long time by children, they may begin to stun. To prevent this, it is necessary to constantly monitor the nature of development.

The effectiveness of Beclazone decreases with cooling. Therefore, before the procedure, it is advisable to hold the inhaler in your hands or put it in a room for natural warming.

Safety instructions for using the inhaler

The medicine in the cartridge is contained under the pressure of compressed gas, so the container must not be heated, pierced or broken. The empty container must be disposed of according to the conditions for this pharmaceutical form. To avoid accidents, do not give aerosol to children.

Side effects and cross interactions

Although the drug Beclazon Eco Easy Breathing is usually well tolerated if the recommendations are followed, it, like any medication, can cause a negative response of the body. Undesirable symptoms are manifested in the form of:

Immune system: angioedema, dyspnea, bronchospasm, anaphylactic reactions
Endocrine system: hypercortisolism syndrome, manifestations of cushingoid, adrenal suppression, growth retardation in children and adolescents
Organs of vision: cataract, in some patients glaucoma is possible
Respiratory organs: irritation of the mucous membrane of the throat, hoarseness, bronchospasm
Skin: rash, itching, urticaria, erythema
Locomotor system: density reduction bone tissue(with systemic exposure)
Psyche: emotional disorder, depression, nervousness, sleep disturbance, children most often have hyperactivity and nervous excitement.

Reception of Beklazon-aerosol with other drugs

So far, no data has been recorded indicating the development of negative reactions after combining beclomethasone with substances of other medications.

During therapy, it should be borne in mind that the combined use of an inhaler with other GCS (for oral or nasal administration) may increase the effect on the adrenal cortex.

If the patient has previously used intranasal drugs of the beta-agonist group, then an increase in the effect of beclomethasone cannot be ruled out.

Overdose

Despite the low toxicity of the metered-dose inhalation aerosol, too frequent or excessive injection can lead to the development of an overdose. In the acute form, there is a decrease in the functioning of the adrenal cortex. Nevertheless, special therapy is not required, since the negative symptom disappears on its own within a few days. The most dangerous thing that can happen after overdose of Beclazone Easy Breathing is the suppression of the hypothalamic-pituitary-adrenal system. But even in this case, there is no need for special measures. It is also not worth interrupting therapy, it should be continued at the prescribed dosage. Restoring the normal functioning of the system takes an average of 1-2 days. You can verify this by reading the plasma content of cortisol.

In the case of prolonged use of overdoses of drugs, a chronic form of overdose and increased suppression of the adrenal glands may occur. In such conditions, it is recommended to constantly monitor the work of the body. Beclazon-Eco treatment instructions for use allow you to continue, but only with strict adherence to the recommended doses.

Analogues

Only a doctor can choose a remedy identical to Beklazone.

TEVA (Israel, Czech Republic)

Average cost: fl. (200 doses) - 196-219 rubles.

The drug is in the form of a spray for intranasal use. Designed for seasonal or permanent use in allergic and vasomotor rhinitis.

The main component of the drug is beclamethasone in the form of dipropionate. Its content in one dose is 50 mcg. The spray neutralizes inflammatory processes, eliminates manifestations of allergies, suppresses local immunity to ensure the therapeutic effect of drugs.

Pros:

Makes breathing easier
Relieves inflammation.

Disadvantages:

Not intended for small children.