Longidaza, suppositories, injections: instructions for use, indications, contraindications, side effects, dosage. Longidaza - instructions for use and reviews Longidaza instructions for use in gynecology
Longidaza - modern drug based on enzymes, which has a proteolytic effect.
The tool improves immunity, allows the body to resist various microorganisms. As practice shows, on its own, the medicine is not able to get rid of any disease, but in complex treatment Longidase suppositories, instructions for use for which are included in the package, give a very good therapeutic effect.
Compound
The preparation contains one active substance - longidase 3000 IU (1 suppository). As an additional ingredient, the composition of the drug includes cocoa butter. Such a component is necessary so that the mass of each suppository is 1.3 g.
Release form
Longidaza is available in the form of torpedo-shaped suppositories (3000 IU) that are administered vaginally and rectally, white in color with a slight characteristic smell of cocoa butter. Candles are placed in separate cells, each blister contains 5 pcs. The drug is packed in a cardboard box with attached instructions.
pharmachologic effect
Longidaza improves the penetration of nutrients under the skin, nourishes tissues, relieves inflammation, reduces swelling, under the action of the active component, scars and hematomas disappear faster, diseased joints return to normal, become mobile due to the fact that the elasticity of damaged joints increases. skin adhesions that occurred before or after surgery disappear after a short period of time.
Faster and more effective medicine helps when the disease is on early stage. In the process of treatment with Longidaza, the therapeutic effect lasts much longer, all this is due to the fact that the active components of the drug are closely related to each other, in addition, the drug has a high activity.
In addition to the fact that the drug relieves inflammation due to its proteolytic effect, Longidase improves immunity and has an antioxidant effect.
The drug completely neutralizes toxins, as a result of which, when they enter the body, they do not pose a strong threat, in addition, the active substance binds heavy metal ions. Longidaza acts in such a way that there are no connective tissue scars on the patient's body. Before using Longidase suppositories, the instructions for use should be studied by each patient, the doctor warns about this.
Clinical studies have shown that Longidaza does not have a toxic effect on the human body, does not have mutagenic and carcinogenic properties. In addition, the drug does not reduce or disrupt the work of the reproductive and immune systems. In most cases, the drug is well tolerated by patients.
Pharmacodynamics and pharmacokinetics
After rectal or vaginal administration, the drug is rapidly absorbed into the tissues and distributed through the blood, its highest concentration was noticed already 1.5 hours after ingestion. The drug does not accumulate in the body, it is excreted by the kidneys after three days.
Candles Longidaza: indications for use and contraindications
Longidaza is prescribed for adults and adolescents over 13 years of age. The drug can be taken both in combination with other drugs, and separately. Candles Longidase, indications for use which are described in the instructions, are prescribed for certain diseases.
Urology
The medicine helps to get rid of chronic prostatitis, and at this stage of treatment, other drugs are also prescribed, since in combination with other drugs, Longidaza gives an even greater therapeutic effect.
Chronic cystitis, including the acute stage, in this case the drug is used separately, only herbal medicines taken orally can be used in a complex way. Violations in the work of the ureters and urethra.
In such diseases, the drug is used as a separate therapy, the use of other drugs in this case is possible only under the supervision of a physician. Benign prostatic hyperplasia in initial stage its manifestations. As a prophylactic treatment for scarred tissue after surgery on the urethra, ureters and bladder.
Instead of Longidaza, in this case, doctors may prescribe treatment with Strovak.
Gynecology
To prevent the formation of adhesions in the pelvic organs, when this is facilitated by diseases of the internal genital organs, manifested with inflammation. As a preventive therapy for the formation of adhesions in the pelvic organs after genital surgery internal organs, including after abortion, operations on the pelvic organs. The drug is prescribed for intrauterine synechia, obstruction of the fallopian tubes, chronic endomyometritis.
Dermatology, venereology
Longidaza is taken with limited scleroderma, promotes the healing of hypertrophic scars, as well as colloid scars. The drug is prescribed as a prevention of complications caused by infections of the genital tract.
Surgery
It is used for the preventive treatment of adhesions formed after surgical interventions on the abdominal organs, as well as for the treatment of wounds that do not heal for a long time.
Pulmonology
Longidaza is prescribed for tuberculosis, pneumonia, pleurisy, alveolitis, siderosis.
Contraindications:
- Longidaza is not prescribed to patients with pulmonary bleeding, when a person is forced to expectorate blood clots.
- The medicine should not be taken in a condition in which a person has a hemorrhage in the vitreous body.
- In the case of malignant neoplasms, the drug may worsen the patient's condition and contribute to the development of the tumor or enable cancer cells progress faster.
- In acute renal failure, the drug is contraindicated, as large amounts are excreted in the urine.
- For pregnant women and women during lactation, the medicine can cause irreparable harm. There have been cases when the active substance of the drug reduced the mental performance of the fetus and caused intoxication of the mother during pregnancy.
- Children under the age of twelve years, the medicine is not prescribed.
- If a person has an increased sensitivity to the components of the drug, otherwise a severe allergy may occur.
With caution and under the supervision of a physician, the drug can be taken by patients diagnosed with chronic liver failure. A large concentration of the active substance is observed in the liver.
The drug should not be taken if the patient has an acute kidney failure. If it is necessary to take this medication, it should be taken no more than once a week, under the supervision of a physician.
Side effects
Longidaza in some patients can cause adverse reactions, they can also occur if the patient has violated the dosage indicated by the doctor. A person from the drug may experience itching on the skin, redness, swelling in the place where the injection was injected, and allergies. As a rule, not severe adverse reactions stop on their own within 2 days.
If the patient has an allergy, in this case, the drug should be discontinued, the attending physician should be informed so that he can select a similar remedy. In order to avoid side effects, before you start taking Longidaza suppositories, the indications for use must be carefully read in the instructions.
Candles Longidaza: application for treatment and prevention
Longidaza is used rectally and vaginally, from this the greatest effect is achieved, so the medicine penetrates directly to the focus of inflammation and is quickly distributed throughout the body.
The general treatment regimen is as follows: once a day, preferably at night, a suppository is inserted, the course of treatment does not exceed 10-18 days.
Adults should insert suppositories one at a time at night, while the suppository is inserted into the vagina in the supine position on its side.
Adolescents over 13 years of age should inject suppositories exclusively into the rectum, also one suppository at night, once a day. Vaginal administration of the drug is contraindicated, since at this age the formation of internal genital organs is fixed in girls. Before starting the introduction, the intestines must be completely cleared, so the drug will begin its action faster. The treatment regimen is determined by the attending physician, first of all, it depends on the severity, duration of the disease, and the age of the patient.
Most often, in adolescents, treatment occurs with interruptions of two days. In any case, if Longidaza suppositories are prescribed, their use should be under the supervision of a specialist. In urology, Longidaza is prescribed one suppository every other day, for a total of 10 injections, after which a two-day break is also taken and 10 injections continue again.
In case of sexually transmitted diseases, the drug is administered one suppository every other day, in general, 13 injections should be obtained. In surgery, the medicine is prescribed one suppository every 3 days, in total there should be 10 injections.
If necessary, the course of treatment can be repeated, but not earlier than after three months. Also long-term treatment can take place according to this scheme: one suppository at night, for seven days, after which they take a break for five days. Such a course should not be less than three and not more than four months.
Overdose
An overdose of the drug can occur if the patient did not comply with the dose prescribed by the specialist or in the case of self-administration of the drug without a doctor's prescription. The patient may feel severe chills, his body temperature may rise, dizziness, vasospasm, dry mouth, nausea, vomiting, and respiratory failure may begin. At visible symptoms overdose needs to start symptomatic treatment. Candles Longidaza, the use of which is controlled by a doctor, should be used carefully so that an overdose does not occur.
Interaction
Longidaza can be taken together with other antibiotics, as a rule, the effect will only get better from this, in addition, the drug goes well with drugs against a virus, a fungus, and it is also often prescribed in combination with bronchodilators.
Longidaza is almost always prescribed with other drugs, since a single treatment with such a drug does not give a pronounced therapeutic effect. However, in combination with antibiotics or diuretics, it must be taken into account that the bioavailability of each drug may increase, and together the agents can have an intense effect on the lesion and on the body as a whole.
If the drug is prescribed with a large dosage of a substance such as cortisone, salicylate, estrogen, there is a decrease in the enzymatic activity of the drug Longidase. It is contraindicated to combine taking this drug with drugs that contain furosemide or phenytoin.
Candles Longidaza with prostatitis: special instructions
The drug can be purchased at pharmacies by prescription.
Storage conditions
Longidaza suppositories are stored at a temperature not exceeding +15 degrees, it is preferable to store them in the refrigerator.
Otherwise, if the temperature is above 16 degrees, the drug will deteriorate, in addition, if the suppositories have softened, it will be problematic to introduce them. The medicine must be safely hidden from children.
Best before date
Subject to the specified storage conditions, the drug can be valid for up to two years.
special instructions
If an allergy occurs, then the patient should stop taking the medicine. Candles Longidase with prostatitis are prescribed in combination with other drugs. If it is necessary to take the medicine during an exacerbation of the infection, then, in addition to the main drug, antimicrobial agents are prescribed. If the expiration date has expired, the color of the suppositories has changed, or if the packaging is visible, the medicine should not be taken.
If the patient missed one dose of the drug, that is, he did not enter the suppository on time, then the medicine is used as usual, do not take a double dosage. If it is necessary to stop taking Longidaza, this can be done immediately without a gradual decrease in dosage. Studies have shown that Longidaza does not affect the ability to manage transport, and concentration does not decrease from it.
Analogues
Ronidaza- the drug is prescribed for the healing of scars caused after burns, after operations or injuries. Also, the remedy is used for ulcers that do not heal for a long time, with hematomas, allergic rhinitis, in case of injury to the nerve plexus, with keratitis.
Polyoxidonium- an immunostimulating drug that enhances the body's resistance to infections of any origin. Prescribed for treatment chronic diseases respiratory apparatus, ENT organs, pelvic organs caused by microbes. The drug is used for complex treatment of many diseases, including the treatment of infections that have entered the body after surgery, as well as for the treatment of allergies, tuberculosis, dysbacteriosis, arthritis, trophic ulcers.
cystamine- the drug is prescribed after radiation therapy received by a person, as well as for the destruction of pathogenic microorganisms that cause various diseases. The tool is used to heal scars, cuts, including promotes the healing of scars formed during operations. In addition, the drug increases the body's resistance to harmful effects environment.
Lidaza M- the drug helps to heal faster wounds resulting from burns, injuries, radiation ulcers, and scars. The drug helps to relieve inflammation in the organs of the upper respiratory tract, in the joints and restore their mobility, is prescribed for pulmonary tuberculosis, neuritis, pleurisy.
Update: October 2018
Longidase is an effective enzyme preparation with proteolytic, i.e. protein-splitting action, as well as immunomodulatory, anti-inflammatory and antioxidant activity. The drug has a long therapeutic effect.
Two active components in the composition of the drug - azoximer bromide and hyaluronidase, lead to the following positive effects:
- improvement of tissue permeability;
- increased trophism;
- resorption of hematomas;
- reduction of edema;
- increase in tissue elasticity;
- disappearance of adhesions and contractures;
- increased joint mobility;
- suppression of connective tissue growth in scars.
Longidaza is able to bind heavy metals and neutralize toxins. The drug does not have a carcinogenic, mutagenic, toxic and embryotoxic effect on the body and is well tolerated by patients - according to reviews, Longidase injections and suppositories do not give unwanted reactions.
Farmgroup: Preparations with proteolytic activity.
The composition of the drug, physico-chemical properties and price
The drug is produced in two dosage forms: suppositories (method of administration rectally or vaginally) and lyophilizate to obtain a solution for subcutaneous or intramuscular administration.
suppositories |
Lyophilisate |
|
| Base substance | Longidase with hyaluronidase activity: 3000 IU | Longidase with hyaluronidase activity 1500 IU (1500 IU ampoules and vials) or 3000 IU ampoules and 3000 IU vials) |
| Excipients | Cacao butter | Mannitol 15 mg (vials and ampoules 1500 IU) or 20 mg (ampoules and vials 3000 IU) |
| Physicochemical characteristics | Candles of an elongated shape, yellowish in color, with a faint smell of cocoa butter. Marble staining of the suppository is acceptable. | The porous hygroscopic mass having white or white-yellow color. |
| Package | 5 suppositories in contour cells, enclosed in cardboard packs. | 5 ampoules or vials in blister packs, enclosed in cardboard boxes. |
| Price |
|
|
pharmachologic effect
The drug has a prolonged enzymatic proteolytic effect. The prolongation of action occurs due to the covalent binding of longidase with a high molecular weight, active carrier (a derivative of poly-1,4-ethylenepiperazine N-oxide), which has pharmacological activity.
The covalent bond ensures the resistance of the enzyme to destructive reactions and the action of inhibitors, as well as the simultaneous local presence of a carrier and a hydrolytic enzyme that binds enzyme inhibitors and activators of collagen synthesis (copper, iron, heparin ions). That is why Longidaza is able to depolymerize the connective tissue matrix in fibrous-granulomatous structures, as well as suppress the regulatory response necessary for the synthesis of connective tissue structural units.
Glycosaminoglycans such as chondroitin, hyaluronic acid, chondroitin-4 and -6-sulfate are specific substrates for testicular hyaluronidase. They form the basis of the connective tissue matrix. As a result of depolymerization under the influence of hyaluronidase, the substrates lose their properties, such as the ability to bind water, viscosity, etc. The conversion of collagen protein into fiber is also difficult, the permeability of tissue barriers increases, the movement of fluid between cells improves and, as a result, the elasticity of the connective tissue improves.
Longidaza helps to reduce the manifestations of the acute phase of inflammation, affects the synthesis of mediators of the inflammatory reaction, increases infectious resistance and enhances the intensity of humoral immunity.
Pharmacokinetics
With the parenteral route of administration, it quickly enters the systemic circulation, reaching a maximum concentration after 20-25 minutes. It is quickly distributed through tissues, penetrates into all organs and structures, including the brain, but does not accumulate.
With rectal and vaginal administration, it also quickly enters the bloodstream, reaching a maximum concentration after 1 hour. The bioavailability of suppositories is 70%. Excreted by the kidneys (half-life is 42-84 hours). Metabolized to low molecular weight oligomers.
Indications for use
It is used in the complex therapy of children from 12 years of age and adults with pathologies that occur with connective tissue hyperplasia. It is also prescribed to improve the bioavailability of diagnostic and therapeutic drugs.
Lyophilisate |
suppositories |
Pulmonology, gynecology and urology in the development of an inflammatory reaction of the interstitial type:
Orthopedics, surgery, cosmetology:
Dermatovenereology:
|
Urology:
Gynecology:
Dermatovenereology:
Surgery:
|
Contraindications
- malignant tumors;
- Pregnancy;
- Children's age up to 12 years;
- Hypersensitivity to Longidase and other drugs with hyaluronidase activity.
In case of insufficiency of kidney function and pulmonary bleeding earlier - appoint no more than 1 time per week.
Lyophilisate
The method of administration and dosing is carried out on an individual basis, based on the severity, clinical pathology and age of the person.
According to the instructions for the use of Longidaza in injections, it is indicated that preliminary preparation of the solution is required. The contents of the vial or ampoule are dissolved in one and a half to two ml of 0.25% or 0.5% procaine solution or in 0.9% NaCl solution, water for injection with intolerance to procaine. The solution cannot be stored, so the field of preparation is introduced immediately.
It is administered subcutaneously near the affected tissue or intramuscularly at a dosage of 3000 IU. In total, 5-15 injections are prescribed with a time interval between each 3-10 days. Repeated course - in 2-3 months.
In pathologies with a severe chronic productive process in the connective tissue after treatment, maintenance therapy is prescribed at 3000 IU after 10-14 days.
To improve the bioavailability of other drugs: 1500 IU once every 3 days, the total number of injections should not exceed 10.
- Pathologies of the respiratory system: 3000 IU once every 3-5 days - a total of 10 intramuscular injections. Maintenance treatment: 3000 IU once every 10-14 days (up to 12 months).
- Pathologies of the pelvic organs: 3000 IU once every 3-5 days with a course of 5-15 intramuscular injections.
- Scleroderma: 3000-4500 IU once every 3 days with a course of 5-15 intramuscular injections.
- Scars: 3000 IU inside the scar at a dose once or twice a week for 5-10 injections or 3000 IU once every 3-5 days - a total of 10 intramuscular injections.
- Non-scarring wounds: 1500-3000 IU once every 5 days with a course of 5-7 intramuscular injections.
- Arthritis, contractures, hematomas: 3000 IU once or twice a week 7-15 intramuscular injections.
- Adhesive disease: 3000 IU once every 3-5 days 7-15 intramuscular injections.
Candles Longidaza: instructions for use
Assigned for rectal or intravaginal administration once a day at night with a course of 10-20 suppositories. For rectal administration, it is recommended to administer the suppository after a bowel movement. With intravaginal administration - administered in the supine position.
- Urology: 1 suppository every 1 day 10 injections, then 2-3 days later - 10 more injections.
- Gynecology: 1 suppository every two days - 10 injections.
- Dermatovenereology: 1 candle in one or two days. For a course of 10-15 candles.
- Surgery: 1 suppository every two to three days. For a course of 10 candles.
- Pulmonology and Phthisiology: 1 candle every two to four days. For a course of 10-20 suppositories. Supportive treatment - 1 suppository once a week for 3-4 months.
Side effects
- Locally: soreness at the injection site, rarely - hyperemia and swelling of the skin. When using suppositories, itching and swelling at the injection site is occasionally possible.
- Rarely, allergic reactions are possible.
- Everything side effects pass after 48-72 hours.
drug interaction
The activity of Longidase decreases with simultaneous treatment with estrogens, salicylates, cortisone, ACTH, antihistamine drugs in high doses. An increase in the bioavailability of the second drug should be taken into account when used simultaneously with Longidase.
special instructions
Longidase should not be injected into the area of acute or infectious lesions. In the treatment of acute foci of infection, antimicrobial agents are simultaneously prescribed.
With the development of any allergic reaction, the drug is canceled.
Overdose
No such cases have been recorded.
Analogues:
A similar composition has Lidaza (10 amp. 200 rubles), Lidaza - M and Ronidaza.
Specialists:
Longidaza with spikes is great help. You should not expect that the drug will remove adhesions, only a surgeon can handle this. But if they are in the initial stage, excision may be necessary, because Longidaza will not allow new adhesions to form and prevent further adhesions.
I have already used this product twice. First, after laparoscopy, my gynecologist included Longidase in the main complex to quickly remove inflammation and swelling. They put suppositories rectally one by one every 2 days. The entire course is 10 candles. After a while, I once again put down candles for prevention. Satisfied with the effect.
A source: http://1mnenie.ru/reviews/longidaza/
Angelina
An ultrasound revealed both an endometrial cyst and adhesions around it. The pain attacked all zones below the waist, even the back was pulled and given to the legs. The gynecologist said the cyst must be removed, and with it, the adhesions should be cut.
The operation was unimportant, I thought that was all, but it turned out that after everything I still had to take a course of suppositories, otherwise adhesions could form again ... I had a longidase 10 injections 1 time in 2 days. Ultrasound showed that everything is OK, there is no adhesive process, I am healthy. I wasn’t particularly happy, I thought it was right, and then a colleague said that after the operation (her tube was removed), adhesions went, and she had to be operated on again (Then I realized that I should say thank you to both the candles and the doctor for my health . Thanks to
A source: https://prozdo.ru/longidaza/comment/78332/#c78332
For the first time, Longidaza suppositories were prescribed to me immediately after laparoscopy of ovarian cysts and hysteroscopy performed in parallel with it.
The surgeon who operated on me said that although this remedy is expensive, it is very effective: it not only relieves inflammation after surgery, but also prevents the formation of adhesions, and in this it has practically no equal.Yes, there is a cheaper Lidaza, but in my case there was no point in it. It is ten times less effective than Longidaza, and the financial savings don't compare to the potential health benefits...
One package of Longidaza cost about 1,600 rubles. It turned out to be very easy to find it - it was in almost every pharmacy. The difference was only in the trading margin.
The medicine is produced in Russia.
In a carton box 10 suppositories of 3000 IU of the active ingredient each.
Suppositories are small, milky white in color, have a cocoa flavor. They are packaged in plastic boxes and should be stored in the refrigerator.
It was necessary to apply Longidaza every other day vaginally or rectally. The doctor left this choice up to me, since there was not much difference in terms of effectiveness - and anyway, the medicine ended up in close proximity to the site of the operation. And the main question was only in the ease of use.
It turned out to be more convenient for me to put candles rectally, because after hysteroscopy, it would be just scary to introduce them ... in another place.
In terms of hygiene, there are no complaints about the candles: they did not leak or stain the linen. side effects like itching and burning, I also did not observe them. The moment of introduction, of course, is an amateur, but otherwise the candles are absolutely invisible.
At the end of the course, I ran like new, I didn’t have any more in the lower abdomen. Ultrasound also showed no abnormalities.
The second time Longidaza was prescribed to me six months later, when at the next follow-up examination, the doctor discovered that I had pain during palpation of the abdomen, in the place where endometriosis foci were cauterized during laparoscopy.
Was it an inflammatory process or already an adhesive one could not be understood, but the repeated course of Longidaza left only memories of pain.
After almost three weeks of using suppositories (every other day), the doctor did not find any soreness or seals. The product worked great again! I don't regret spending money.
I hope that you will never need this medicine, but if the doctor prescribes it to you, then there are indications for this and it is definitely not worth saving on health.
Recommend!
Dubrovina S.O.
(Rostov-on-Don)
Professor, MD
Longidase® has a complex triple action: antifibrotic, anti-inflammatory, anti-edematous. The drug not only prevents the formation of new adhesions and scars, but also affects already formed adhesions, reducing the risk of chronic pelvic pain and infertility.
Zaitsev A.V.
Professor, MD
The role of fibrosis in the development of dysfunction of the lower urinary tract continues to be intensively studied using modern methods diagnostics.
The need for complex treatment of patients with chronic prostatitis, benign prostatic hyperplasia in combination with chronic inflammation, urethral strictures and interstitial cystitis is beyond doubt. As an element of complex therapy, it is necessary to prescribe drugs with an antifibrotic mechanism of action. After the use of the drug Longidaza® in patients, there is a significant improvement in the results of treatment of patients in these groups, the results of studies have been reflected in a number of publications.
Buyers:
Pharmacological. Longidase has hyaluronidase (enzymatic proteolytic) activity of prolonged action, chelating, antioxidant, immunomodulatory and moderately pronounced anti-inflammatory properties.
The prolonged action of the enzyme is achieved by covalent binding of the enzyme to a physiologically active high molecular weight carrier (activated derivative of 1\\[-poly-1,4-ethylenepiperazine oxide, polyoxidonium analogue), which has its own pharmacological activity. Longidase exhibits anti-fibrotic properties, weakens the effect of the acute phase of inflammation, regulates (increases or decreases depending on the initial level) the synthesis of inflammatory mediators (interleukin-1 and tumor necrosis factor alpha), increases the humoral immune response and the body's resistance to infection.
Pronounced anti-fibrotic properties of Longidase are provided by conjugation of hyaluronidase with a carrier, which significantly increases the resistance of the enzyme to denaturing effects and the action of inhibitors: the enzymatic activity of Longidase is preserved when heated to 37 ° C for 20 days, while native hyaluronidase loses its activity under the same conditions. during the day. The Longidase preparation provides the simultaneous local presence of the proteolytic enzyme hyaluronidase and a carrier capable of binding the enzyme inhibitors released during hydrolysis and stimulators of collagen synthesis (iron ions, copper ions, heparin, etc.). Due to these properties, Longidase has not only the ability to depolymerize the connective tissue matrix in fibrous-granulomatous formations, but also to suppress the reverse regulatory reaction aimed at the synthesis of connective tissue components.
The specific substrate of testicular hyaluronidase is glycosaminoglycans (hyaluronic acid, chondroitin, chondroitin-4-sulfate, chondroitin-6-sulfate), which form the basis of the connective tissue matrix. As a result of depolymerization (breaking the bond between C1 acetylglucosamine and C4 glucuronic or induronic acids), glycosaminoglycans change their basic properties: viscosity decreases, the ability to bind water, metal ions decreases, the permeability of tissue barriers temporarily increases, the movement of fluid in the intercellular space is facilitated, the elasticity of the connective tissue increases. tissue, manifested in a decrease in tissue swelling, flattened scars, an increase in the range of motion of the joints, a decrease in contractures and the prevention of their healing, a decrease in the adhesive process. Biochemical, immunological, histological and electron microscopic studies have shown that Longidaza does not damage normal connective tissue, but causes destruction of the connective tissue changed in composition and structure in the area of fibrosis.
Longidase does not have mutagenic, embryotoxic, teratogenic and carcinogenic effects.
The drug is well tolerated by patients, no local and general allergic reactions were noted.
The use of Longidaza in therapeutic doses during or after surgical treatment does not cause deterioration of the postoperative period or progression of the infectious process; Does NOT slow down bone regeneration.
Pharmacokinetics. An experimental study of the pharmacokinetics of suppositories with a tritium-labeled enzyme carrier made it possible to establish that, when administered rectally, the drug is characterized by a high distribution rate in the body, is well absorbed into the systemic circulation, and reaches its maximum concentration in the blood after 1:00. The half-life is about 0.5 hours, the half-life is from 42 to 84 hours. It is excreted mainly by the kidneys.
The drug penetrates into all organs and tissues, including passing through the hematoencephalic and hematoophthalmic barriers. The absence of tissue cumulation was established.
Bioavailability of rectal suppositories Longidase - not less than 70%.
The drug "Longidaza" is a good helper in medicine and has a wide range of applications. Medicine has an anti-inflammatory effect and is an immunomodulator. Specialists actively use Longidaza suppositories in gynecology. This medicine perfectly copes with inflammation of the internal female genital organs. In addition, the release form in the form of a suppository is very effective for such purposes. This tool is very popular today.
Drug properties
chief active substance means is longidase. It consists of the enzyme hyaluronidase and a special carrier component. Such a compound gives the drug high resistance to harmful factors and prolongs the effect of the drug. Due to these properties, suppositories are more efficient in therapy. They are very different from many medicines that have hyaluronidase in their composition.
Longidaza candles are characterized by the following:
- Have an antioxidant effect;
- Have anti-inflammatory action;
- Contribute to increased hypersensitivity reactions;
- Help with microcirculation of fluid in the extracellular space;
- Helps enhance the elimination of toxins from body tissues;
- Reduce the obvious signs of adhesive processes in the internal female genital organs.
The Longidaza agent directs the therapeutic effect exclusively to the damaged tissues of the body, does not accumulate in them, and spreads quite easily. Is an safe means, which does not cause teratogenic, embryotoxic and carcinogenic effects. Does not enhance infectious processes in the human body. It is often resorted to after operations in preventive measures, as well as in order to support the body during recovery.
Indications for use
The medicine Longidaza is used in the presence of such diseases:
- ovarian cyst;
- Asherman's syndrome;
- Chronic inflammation of the lining of the uterus (endomyometritis);
- uterus.
Often the medication is used as a prophylactic after an abortion or surgery.
A suppository is a pretty universal medicine. It is actively used in many fields of medicine. For example, for the treatment of urological diseases.
The tool is great too. restores the reproductive system. Women who plan often use this drug for the next year. A full course of therapy promotes better patency of the fallopian tubes and improves the structure. In addition, fertility is restored. These improvements help to conceive a baby and accompany a healthy pregnancy.
The healing components, once in the female body, are easily spread through the tissues. It is for this reason that you can observe a quick result from Longidaza. As a rule, the drug is excreted by the kidneys.
Contraindications and side effects
Each drug can cause side effects and has contraindications. However, thanks to research, it was found that Longidaza does not provoke side complications in the body. An exception to the rule can be considered individual intolerance, which implies an allergy.
Using suppositories, it is necessary to remember the consequences of complex treatment with other drugs. For example, synchronous therapy with Longidase or painkillers increases their effect.
Despite the safety of the drug, there are some restrictions that do not allow the use of candles. Longidaza is not recommended in such cases:
- Availability infectious diseases with acute flow;
- Malignant;
- Violation of the activity of the adrenal glands;
- Children under 12;
- The period of pregnancy and lactation.
Long-term use of the drug is harmful. In case of overdose, muscle tremors, low blood pressure and hyperthermia have been observed. Candles do not affect the ability to drive a car. The drug is completely eliminated from the body in 2-3 days.
How to apply?
Candles are administered in two ways - vaginally or rectally. However, it should be borne in mind that the second method is less effective and reduces the therapeutic effect on the body. It is used when a woman is menstruating. Before you enter the suppository into the rectum, you must perform one action. It is very important to empty the bowels with a cleansing enema. But if it is possible to start therapy after menstruation, it is advisable to wait until this moment, since experts advise the vaginal method of administration.
According to the instructions, the medication is used once a day. It is extremely important to know that the procedure must be done at night. Treatment lasts from 10 to 20 days. The course is prescribed exclusively by the doctor, based on the patient's condition and the severity of his illness. It is possible that after a course of therapy you will need prophylactic use facilities. Usually the suppository is used once a week for 3-4 months.
Popular analogue
Longidaza is not a cheap drug. Therefore, many women are looking for cheaper analogues. Lidaza is considered the most common replacement. However, it is impossible to call this medication a full-fledged analogue, since Longidase suppositories in gynecology are equated in their composition with an almost unique drug.
Lidaza is available as an injection. Helps reduce swelling of tissues, promotes their permeability and elasticity. Softens scars well. The use of the drug during breastfeeding and pregnancy is prescribed exclusively by a doctor. The therapy is carried out under the strict supervision of a specialist.
Taking medication is prohibited. So, the following symptoms may occur:
- Vomit;
- Painful palpitations;
- Nausea;
- Small swelling;
- Shiver;
- Headache;
- Loss of balance.
Before replacing Longidase with other drugs, you should consult with a specialist. A frivolous attitude to treatment can lead to complications.
Video about suppository treatment
In this video you will learn about the treatment of ovarian cysts: