Askofen p indications instructions for use. Askofen-P: instructions, indications, price, analogues, reviews

Askofen is a drug of combined effects. Designed to eliminate pain, lower body temperature and restore normal blood pressure. It is allowed to use Askofen during pregnancy on early dates but you should consult your doctor before use.

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Composition features

Askofen P contains acetylsalicylic acid, which has analgesic properties and relieves fever, blocking the development of inflammation.

This substance inhibits enzymes that are involved in the formation of prostaglandins that block the release of inflammatory mediators.

The next ingredient is caffeine. Its effect is observed in the removal of headaches in humans. The exercise component reduces the excitability of the spinal cord.

Attention! Askofen effectively helps with headaches, dilates blood capillaries, neutralizing pain.

Using the pills, the patient feels a surge of energy, lack of fatigue and drowsiness, the pain is neutralized not only in the head, but also in other parts of the body. Motor activity returns to normal, the brain begins to work hard. The tone of the capillaries of the brain returns to normal, which stimulates blood flow.

The composition of Askofen P includes not one active substance, but several:

acetylsalicylic acid - normalizes body temperature, eliminates inflammation and anesthetizes;
phenacetin - normalizes temperature indicators, preventing them from falling to a minimum value;
- serves to eliminate pain, relieve swelling of the limbs and eliminate heat in diseases;
caffeine - has a tonic effect, increases mental and physical activity normalizes the work of all body systems.

The interaction of these components leads to an increase in the positive effect. Due to this composition, it is possible to use b Askofen during early pregnancy to eliminate pain in the head or lower back. The components do not adversely affect the developing fetus in the first weeks of gestation.

The drug is available only in the form of dragees. Askofen tablets are presented in a flat-cylindrical form of a light shade. The tool does not have a specific aroma or taste, so it is easily accepted by both kids and adults. In the pharmacy, the medication can be purchased in packages with 1-2 blisters of 10 tablets.

Indications for use

The drug is designed to eliminate pain in any part of the body, so it is recommended as a therapy for various diseases.

Indications for use medicinal product:

colds with fever;
radicular syndrome of the cervical, lumbar or thoracic regions;
cramps during menstruation;
removal of toothache;
elimination of pain in the head, muscles or joints;

How does it affect pressure

The drug is aimed at eliminating pain in the body. To reveal how Askofen works - it increases or lowers pressure, you can only do it yourself.

What effect do the individual components have on a person:

Acetylsalicylic acid is able to slightly expand blood capillaries. At the same time, the level of hemoglobin decreases, which leads to poor blood clotting;
Phenacetin - does not affect blood flow or pressure;
Paracetamol - creates a slight positive effect at reduced pressure, normalizing the human condition. At high blood pressure the use of the drug does not bring the desired result;
Caffeine is the only ingredient that increases arterial pressure. Doses in tablets are enough to increase the performance and keep them at a certain level for a long time.

As experiments have shown, with increased pressure, taking this medication does not have a special result. Only if the pressure is fixed at the lower levels, a positive effect is possible.

Askofen at low pressure is more effective, increases its rate, which leads to the normalization of all processes in the body. Eliminated headache and lethargy, drowsiness goes away, there is a desire to work

Attention! Hypertensive patients need to use the drug carefully, constantly monitoring their condition and pressure indicators.

Using the drug, it is impossible to provoke the occurrence of a hypertensive crisis. This is due to the fact that the dosage of caffeine in tablets with short-term use for therapy is not able to negatively affect the patient's well-being. But before using the drug, it is recommended to consult with your doctor.

Use during pregnancy

During the period of bearing a child, any use of drugs is not desirable. Doctors do not advise a pregnant woman to be exposed to viruses and pathogenic bacteria. This can harm the development of the unborn child.

The drug can be used during pregnancy. This is due to the fact that its composition does not contain substances belonging to the group of antibiotics. An important point is that the drug does not have a significant list of contraindications.

During early pregnancy, this remedy used if the woman is infected with a viral disease. The drug at the initial stages of the disease quickly reduces the temperature to normal level and relieves general malaise.

Askofen during early pregnancy does not always effectively eliminate the symptoms of migraine. A positive effect is detected with a non-intense toothache or headache.

Before use, be sure to visit a gynecologist and talk about the symptoms of malaise. The doctor will select an individual dosage at which side effects will not appear.

Attention! Improper intake and increased dosage in the first trimester of pregnancy can provoke the development of a defect in the fetus in the form of a split palate, which is called the cleft palate.

children, under the age of 15, the use of the drug is strictly prohibited. Adolescents from 15 years old can be used as an antipyretic and analgesic.

Contraindications

Before you start taking it, you need to familiarize yourself with the indications that prohibit the introduction of the drug into the body to obtain a therapeutic effect.

There are the following contraindications:

problems with the functioning of the digestive organs;
the period of feeding the baby with breast milk;
disorders in the liver or kidneys;
diseases respiratory system(bronchial asthma);
individual intolerance to the drug or its constituent ingredients;
age restrictions - up to 15 years;
cardiovascular disorders and nervous system;
aortic aneurysm (dissecting).

If a patient has contraindications, it is not recommended to use the medicine, side effects may occur. If negative effects appear after the onset of the drug, you should stop using it. After giving up medicines, you need to wash your stomach and contact your doctor for the selection of substitutes.

Analogues

Askofen has an analogue - Citramon. To identify which is better - Askofen or Citramon, allows a comparison of their common features and distinctive features.

Both drugs are identified as non-steroidal anti-inflammatory drugs. The drugs have the same composition and the country of origin - Russia. The release is carried out only in tablet form.

Citramon differs from Askofen in that it additionally contains citric acid and cocoa, which enhance the taste and aroma of the medicine.

Attention! The main difference between drugs is different dosage. Askofen has 40 mg less aspirin than Citramon. But there is much more caffeine and paracetamol - by 20 and 10 mg, respectively. But minor deviations in dosages do not affect the degree of positive effect.

It is difficult to determine exactly which Askofen or Citramon is better. Medicines have an identical spectrum of action and give the same result after administration.

Useful video: instructions for use of Askofen-p

Thus Askofen is effective drug. The main thing is to take the medicine in the doses prescribed by the doctor.

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Askofen is a combined drug with analgesic, antipyretic and mild psychostimulant effect. It is intended for symptomatic therapy and does not affect the cause of the pathology and the overall duration of the disease.

Components and dosage form

The medicine is available in the form of tablets for oral intake. 1 tablet of Askofen contains 0.2 g acetylsalicylic acid, 0.2 g phenacetin and 0.04 g caffeine. The drug Askofen P instead of phenacetin contains a safer component - (0.2 g). Tablets are supplied in cell packs (10 pcs.).

In what cases is Askofen prescribed?

Other indications include:

Who should not take Askofen?

The drug should not be used in patients with individual hypersensitivity to one or several of its components at once in order to avoid the development of allergic reactions.

Diseases and pathological conditions that are contraindications:

erosion and (in the acute stage);
gastrointestinal bleeding;
exfoliating;
coronary vessels;
pronounced functional;
severe kidney dysfunction;
portal hypertension;
poor blood clotting;
diseases of the hematopoietic system;
"aspirin triad" (+ nasal polyposis + intolerance to salicylates or other NSAIDs).

Note:The drug is not prescribed for children and adolescents under 15 years of age!

Dosages

A single dose for the relief of pain syndrome of moderate intensity - 1 tab.; at severe pain you can take 2 pieces at once. Multiplicity of reception - no more than 3 times a day. The drug is strongly recommended to drink after meals, with plenty of liquid. It is advisable to take the tablets with milk or alkaline mineral water to reduce irritation of the mucous membranes of the digestive tract.

Important:Askofen should not be taken for longer than 1 week in a row (to reduce the temperature - more than 3 days). If you need to continue treatment, you should consult with your doctor. Long-term therapy requires monitoring of the picture of peripheral blood and liver function.

pharmachologic effect

Acetylsalicylic acid inhibits the process of biosynthesis of pain and inflammation mediators - prostaglandins, thereby reducing swelling and the severity of pain in diseases of inflammatory origin. This substance is able to slow down platelet aggregation, which reduces the risk of thrombosis, but increases the likelihood of bleeding. The analgesic and antipyretic properties of acetylsalicylic acid are enhanced by phenocetin. The paracetamol present in Askofen-P indiscriminately blocks the cyclooxygenase enzyme, which helps to reduce the production of prostaglandins. It also directly affects the hypothalamic thermoregulatory center. Its advantage over phenocetin is that methemoglobin is not formed during metabolism. Caffeine has psychostimulant and vasodilating properties. This component normalizes the tone of cerebral vessels, accelerates blood flow, reduces the feeling of physical and mental fatigue and excites the respiratory center. The substance enhances the effect of other ingredients.

After oral administration, the active components are absorbed in the gastrointestinal tract quickly and almost completely (about 90%). The process of biotransformation takes place in the liver, and the excretion of unchanged substances and their metabolites is carried out mainly through the kidneys (approximately 80%); some is excreted in the bile.

Interaction with other drugs

Askofen potentiates the action of anticoagulants of indirect action and antiaggregants, and therefore, the risk of bleeding of various localization increases. It also enhances the effect of hypoglycemic drugs and steroids (glucocorticoids increase the likelihood of developing glaucoma).

With parallel administration, the effectiveness of individual diuretics also decreases.. Severe poisoning, even with a slight excess of the permissible dosages, can develop if the patient receives Phenytoin, tricyclics, Rifampicin or Zidovudine.

During treatment, it is highly undesirable to take other NSAIDs, since the risk of toxic effects on the kidneys increases.

Side effects

Most patients tolerate the treatment with Askofen well.

If you are allergic to the components, the appearance of skin itching and, as well, is not excluded. In severe cases, anaphylactic shock is possible.

V rare cases during therapy, the following side effects are noted:

feeling tired;
dyspeptic disorders;
violation of the clarity of visual perception near;
pain in the epigastrium (with the development or exacerbation of a and);
discomfort or pain in the abdominal region (with liver damage).

Askofen during pregnancy

The components of the drug are absorbed into the systemic circulation, bypass the hemato-placental barrier and penetrate into the breast milk. It does not have an embryotoxic and mutagenic effect, but it is better to refuse this medication for the period of gestation and breastfeeding, especially in IandIIItrimesters. If it is necessary to carry out symptomatic therapy during lactation, you should definitely consult with your doctor. In such cases, it is usually recommended to temporarily switch the child to artificial milk formulas.

When there is a different kind pain Most people first turn to medications for help. One of these is Askofen-p. It is a drug that has a combined composition. In addition to getting rid of pain, Askofen has antipyretic and anti-inflammatory effects.

Askofen - p simultaneously refers to both the group of antipyretics and analgesics. The presence of paracetamol in the composition allows you to effectively knock down elevated body temperature.

In addition, there is a powerful anti-inflammatory effect. Acetylsalicylic acid, which is one of the active ingredients, has the ability to thin the blood. The effect of aspirin is aimed at preventing the appearance of blood clots. Caffeine dilates blood vessels, activates vasomotor and respiratory processes.

In addition to the above, it has an exciting effect, depriving drowsiness and a broken state. Askofen - n is indicated for:

Tooth pain syndrome;
protracted migraines;
Lumbago syndrome;
Myalgia;
Algodysmenorrhea;
Increase in body temperature;
The presence of viral diseases;

Contraindications

Despite its effectiveness, it is far from possible to take Askofen in all cases. The point is that this medicine has a number of contraindications.

It is very important to consider them before you start taking. In addition, the use of alcoholic beverages is prohibited while taking the drug. It can cause bleeding in the organs gastrointestinal tract . Askofen-p should not be taken in the presence of the following conditions:

Asthma;
Deviations in the work of the kidneys and liver;
insomnia;
Diseases of the cardiovascular system;
Dissecting aortic aneurysm;
Internal bleeding of any kind;
Hemorrhagic diathesis;
Individual reactions to the components of the drug;
Lack of vitamin K;

Dosage and method of application

At long-term treatment and the drug is prescribed to drink 1-2 tablets up to three times a day, depending on the complexity of the disease. For a one-time relief of pain, 1-2 tablets of Askofern are taken - p. The daily dose should not exceed more than 6 tablets. Reception is carried out after the process of eating.

It is necessary to ensure that the duration of the break between doses is at least 4 hours. Reception is carried out orally with the use of large amounts of water. You can also drink the drug with milk or sparkling water.

As an anesthetic, Askofen-p is used for no more than 5 days; to lower the temperature, you should not use it for more than 3 days. In other cases, the dosage is prescribed individually by the attending physician.

Side effects

With an increase in dosage or longer use of the drug, it is possible occurrence of side effects. They manifest themselves in violation of the functions of the kidneys and liver and exacerbation of peptic ulcer. In the presence of bronchial diseases, taking Askofen-p can provoke an increase in asthma.

With a single dose of the drug, allergic reactions of an individual nature may occur. As a rule, they appear in the form of characteristic rashes, itching, redness of the skin, etc. The occurrence of such a phenomenon provokes one of the active components of the drug.

If any of these symptoms occur, stop taking and consult a specialist. During treatment, he must monitor the work of the liver and blood counts.

Overdose

Askofen - n refers to drugs, the intake of which implies compliance with the dosage. Otherwise, unpleasant reactions of the body may occur. With an overdose of the drug, nausea, dizziness, ringing in the ears appear. The patient notices characteristic sensations in the stomach, increased sweating and chills appear.

At the same time, the skin begins to turn pale, breathing difficulties appear. In some cases, bleeding may open or seizures begin. When establishing symptoms of poisoning, it is urgent to call an ambulance.

To eliminate the symptoms, the patient is hospitalized or treated in a hospital, depending on the severity of the poisoning. In this state, the standard gastric lavage and taking activated charcoal.

Interaction with other drugs

Askofen's reception - n has a number of nuances in use. It can enhance the effect of some medicines when taken at the same time. These include drugs containing heparin, indirect anticoagulants and hormonal drugs.

Medicines that are used to remove uric acid from the body reduce their effect under the influence of Askofen - p. Simultaneous administration also enhances the side reactions of analgesics and anti-inflammatory drugs. Therefore, one should be extremely careful when carrying out complex treatment.

Storage of the medicinal product should be carried out in a dark place, with a temperature not exceeding 25 ° C. Two years after manufacture, the drug is not suitable for use. In this case, there will be no benefit from the medicine, and harm is likely.

Despite its positive qualities, Askofen is not the only one of its kind. As analogues of the drug, you can use Citramon, Upsarin Upsa, Aspirin or Citropack. These drugs are similar to Askofen - n in their effects.

The cost of the drug may vary, depending on the place of purchase and the company of production. On average, the cost ranges from 20 to 50 rubles per pack, which is a blister with 10 tablets. Since the drug is able to influence the blood coagulation process, the attending physician should be warned about taking it in case of an upcoming surgical intervention. This is extremely important.

The use of the drug in this case will be canceled. If there is even a slight sensitivity to the components of the drug, vigilance should be exercised during administration. For example, in patients suffering from a certain predisposition, taking Askofen - n can provoke gout.

During pregnancy

Experts do not advise pregnant women to take Askofen-p. However, there are situations when it is simply necessary. In the first and third trimesters, the use of the drug is strictly contraindicated. In the second trimester, a single dose is possible. But there must be good reasons for this, since Askofen-p can have a negative effect on the development of the fetus.

On the early pregnancy it can provoke its interruption. In addition, there is a possibility of a splitting of the upper palate if you take the medicine in the first trimester of pregnancy. At the end of pregnancy, the use of the drug can affect blood circulation, the process of labor and cause pulmonary vascular hyperplasia in the fetus.

Sometimes such a symptom of pregnancy as a rise in temperature, women mistakenly take the onset of a cold, and take Askofen-p. As a rule, in such situations the risk possible complications extremely low. But you can protect yourself by drinking an activated charcoal tablet.

Raises or lowers blood pressure

Very often Askofen-p is taken and under reduced pressure. There is no information in the manual about this. But this fact exists. The composition of the drug includes caffeine, which can increase blood pressure and improve the condition of hypotensive patients. When it is taken, efficiency increases, weakness and a feeling of drowsiness disappear, dizziness disappears.

Askofen-p is relevant when changing climatic conditions. It is during this period that most people experience strong pressure surges. However, it should be remembered that the drug is not a panacea for regulating pressure, since not a word is indicated in the instructions about this.

In exceptional cases, hypotensive patients can take the drug, but with extreme caution. People with the reverse problem also wonder if they can use this drug. Since it can significantly increase blood pressure, its intake should be minimized or completely eliminated.

When breastfeeding

During breastfeeding it is strictly forbidden to take Askofen-p. With an urgent need for admission, it is recommended to stop breastfeeding, replacing it with artificial. Together with mother's milk, not only useful, but also harmful substances enter the child's body.

Entry of the active ingredients of the drug into the body small child fraught with consequences. Askofen's reception - n at breastfeeding can lead to problems with cardiovascular system , decreased efficiency of the kidneys and liver, hormonal changes, etc.

In addition, while taking the medicine, the child may develop chronic intestinal dysbacteriosis. Acetylsalicylic acid, which is the active ingredient of the drug, can cause bleeding, as a result of dysfunction of blood clots.

Each tablet contains active ingredients: 200 mg, 200 mg, caffeine 40 mg.

Excipients: stearic acid, povidone, potato starch, talc, calcium stearate, silicone emulsion and .

Release form

Askofen-P is produced in the form of tablets of a light shade, flat-cylindrical shape without a special odor. In pharmacies, the medicine is sold in packs of 10 pieces.

pharmachologic effect

The drug has a combined effect, combining non-steroidal anti-inflammatory, analgesic non-narcotic and psychoactive effect.

Pharmacodynamics and pharmacokinetics

Combined drug, the effectiveness of which is ensured by its constituent components.

Long-term medication causes: , noise in ears, , hypocoagulation, a variety of undesirable syndromes and disorders of the liver .

Askofen tablets, instructions for use (Method and dosage)

As the instructions for the use of Askofen-P indicate, these tablets are prescribed for taking after meals 2-3 times a day in the amount of 1-2 pieces. In this case, the maximum daily dosage should not exceed 6 pieces, and the break should be less than 4 hours.

Given the indications for the use of Askofen, you need to observe some features of the reception:

it is better to drink tablets with milk, ordinary warm or mineral water;
patients with impaired renal or liver function should increase the interval between taking the medicine - from 6 hours.

In addition, the course of analgesic therapy should not exceed 5 days and fever treatment - more than 3 days. In other cases, the duration of treatment and dosage is determined by the doctor.

Overdose

In case of an overdose, it may appear:

nausea, vomiting, pain in the gastrointestinal tract;
sweating, pale skin;
tachycardia;
tinnitus;
, collapse, convulsive state;
bronchospasm, breathing problems and so on.

If there is suspicion of poisoning then you need to call for medical help immediately. Usually, the victim is washed with a stomach and prescribe adsorbents.

Interaction

Simultaneous treatment with Askofen-P leads to increased action, , indirect anticoagulants, and some hypoglycemic agents . It is also likely to reduce efficiency. , , hypotensive and anti-gout drugs which help to remove uric acid from the body.

Increased side effects noted glucocorticosteroids , derivatives sulfonylurea , as well as non-steroidal anti-inflammatory drugs and non-narcotic analgesics.

It is not recommended to combine this medicine with barbiturates , antiepileptic drugs, zidovudine, rifampicin and alcohol-containing drinks, because the likelihood of developing a hepatotoxic effect remains.

The influence of paracetamol increases the elimination period by almost 5 times. As for caffeine, it promotes absorption ergotamine.

Combination therapy with Salicylamide and other stimulants of microsomal oxidation contribute to the production of toxic metabolites paracetamol that adversely affect liver function.

Simultaneous reception with enhances absorption paracetamol . Repeated use can increase the effect of anticoagulants.

special instructions

Long-term treatment with this drug requires monitoring of peripheral blood and liver function.

Acetylsalicylic acid has an antiplatelet effect, for this reason, patients should immediately warn doctors before undergoing surgery that they are taking this drug. Low doses of acetylsalicylic acid reduce the excretion of uric acid, which often provokes a gout attack.

Terms of sale

These tablets are available without a prescription.

Storage conditions

The drug should be stored in a fairly dry and dark place at temperatures up to 25 ° C.

Best before date

The drug is valid for 2 years.

Analogues

Coincidence in the ATX code of the 4th level:

Drugs also have a similar effect: Orafen, Bofen other.

Alcohol and Askofen-P

When treating with this drug, the use of any alcoholic beverages is prohibited, as they increase the risk of bleeding in the gastrointestinal tract.

One tablet contains

active substances: acetylsalicylic acid 200 mg, paracetamol 200 mg, caffeine 40 mg;

Excipients: potato starch, povidone, calcium stearate.

Description

Tablets are white or white with a creamy or pinkish tint, flat-cylindrical, with a notch and a chamfer, marbling is allowed on the surface.

Pharmacotherapeutic group

Acetylsalicylic acid in combination with other drugs (excluding psycholeptics).

ATC code N02BA51

Pharmacological properties"type="checkbox">

Pharmacological properties

Pharmacokinetics

Acetylsalicylic acid rapidly and completely absorbed mainly in the upper small intestine. The half-life is 5-16 minutes. Milk and antacids do not reduce the rate of absorption. Acetylsalicylic acid and its main metabolite (salicylic acid) bind to proteins through their phenolic hydroxyl groups. It is excreted mainly through the kidneys. Paracetamol quickly and almost completely absorbed from the gastrointestinal tract, evenly distributed in the tissues. The maximum plasma concentration is reached after 2.5 hours, the half-life is 2-4 hours, the bioavailability is about 90%, the degree of binding to blood proteins is 25-50%, it is metabolized mainly in the liver (up to 80-90%). The combination of acetylsalicylic acid and paracetamol provides a more pronounced and prolonged analgesic, antipyretic and anti-inflammatory effect than when taken separately in equivalent doses, due to the possible competition between acetylsalicylic acid and paracetamol for binding to plasma proteins, and paracetamol exhibits greater reactogenicity. This somewhat lengthens the period of circulation in the blood of free (active) acetylsalicylic acid.

Caffeine potentiates the action of paracetamol and acetylsalicylic acid.

Pharmacodynamics

The combined drug has analgesic, antipyretic and anti-inflammatory effects.

Acetylsalicylic acid It has antipyretic and anti-inflammatory effects, relieves pain, especially caused by the inflammatory process, and also moderately inhibits platelet aggregation and thrombosis, improves microcirculation in the focus of inflammation.

Paracetamol has an analgesic, antipyretic and weak anti-inflammatory effect, which is associated with its effect on the thermoregulatory center in the hypothalamus and a less pronounced ability to inhibit the synthesis of prostaglandins in peripheral tissues.

Caffeine increases the reflex excitability of the spinal cord, stimulates the respiratory and vasomotor centers, dilates the blood vessels of the skeletal muscles, brain, heart, kidneys, reduces platelet aggregation; reduces drowsiness, fatigue, increases mental and physical performance. In this combination, caffeine in a small dose has practically no stimulating effect on the central nervous system, but it helps to normalize the tone of the brain vessels and accelerate blood flow.

Indications for use

Pain syndrome weak and moderate intensity of various origins (headache, toothache, neuralgia, primary dysmenorrhea)

Diseases accompanied by fever of various etiologies.

Methods of application and doses

Take orally 1 tablet 2-3 times a day after meals. Maximum daily dose is 6 tablets in 3 divided doses. The course of treatment depends on the effectiveness of therapy.

The course of treatment - no more than 5 days as an anesthetic and no more than 3 days - as an antipyretic.

Apply as directed by a doctor.

Side effects

Anorexia, nausea, vomiting, gastralgia, diarrhea

Erosive and ulcerative lesions of the gastrointestinal tract

Liver and/or kidney failure

Increase in blood pressure

Tachycardia

allergic reactions ( skin rash, angioedema, bronchospasm)

With long-term use:

Dizziness, headache

Decreased platelet aggregation, hypocoagulation

Hemorrhagic syndrome (nosebleeds, bleeding gums, purpura, etc.)

Kidney disease with papillary necrosis

Deafness

Steven-Johnson Syndrome

Toxic epidermal necrolysis (Lyell's syndrome)

Reye's syndrome in children (metabolic acidosis, disorders of the nervous system and psyche, vomiting, abnormal liver function)

Contraindications

Peptic ulcer of the stomach and duodenum

Gastrointestinal bleeding

Reduced blood clotting

Hemorrhagic diathesis (Willebrand disease, hemophilia, telangiectasia, hypothrombinemia, thrombocytopenia, thrombocytopenic purpura)

Dissecting aortic aneurysm

Anxiety, sleep disturbance, anxiety disorders

Organic diseases of the cardiovascular systems ( acute infarction myocardium, severe course coronary disease heart, arterial hypertension)

Severe liver and kidney dysfunction

Pregnancy, lactation

Glucose-6-phosphate dehydrogenase deficiency

Individual intolerance to acetylsalicylic acid and / or paracetamol

Children's age up to 15 years

Drug Interactions"type="checkbox">

Drug Interactions

Enhances the effect of heparin, indirect anticoagulants, reserpine, steroid hormones and hypoglycemic agents. Reduces the effectiveness of spironolactone, furosemide, antihypertensive drugs, anti-gout agents that promote the excretion of uric acid.

Strengthens side effects glucocorticosteroids, sulfonylurea derivatives, methotrexate, non-narcotic analgesics and non-steroidal anti-inflammatory drugs.

The combination of the drug with barbiturates, antiepileptic drugs, zidovudine, rifampicin, and alcoholic beverages should be avoided (increases the risk of a hepatotoxic effect).

Under the influence of paracetamol, the elimination time of chloramphenicol increases by 5 times. Caffeine accelerates the absorption of ergotamine.

Salicylamide, and other stimulants of microsomal oxidation contribute to the formation of toxic metabolites of paracetamol that affect liver function. Metoclopramide accelerates the absorption of paracetamol. When taken repeatedly, paracetamol may enhance the effect of anticoagulants (dicoumarin derivatives).

special instructions"type="checkbox">

special instructions

The drug should be used with caution in patients with bronchial asthma and gout. During treatment, you should stop drinking alcohol.

Application in pediatric practice

The drug is not prescribed as an anesthetic for persons under 18 years of age, as an antipyretic - for children under 15 years of age with acute respiratory infections caused by viral infections due to the risk of developing Reye's syndrome (encephalopathy and acute fatty degeneration of the liver with acute development liver failure).