Suprax® Solutab® dispersible tablets. Suprax solutab - instructions, indications, composition, method of application Release form and packaging
Some facts about the product:
Instructions for use
Price in the online pharmacy site: from 780
Pharmacological properties
Suprax Solutab is a semi-synthetic antimicrobial drug for oral administration. Possesses bactericidal quality. The mechanism of influence on human biosystems is the inhibition of the process of synthesis of the membrane of the cellular structure of the pathogen. The substance cefixime in most cases can resist β-lactamases, which produce some types of pathogenic bacterial forms.
After the introduction of the drug, the bioavailability of the substance is up to 50%. Moreover, the time of eating food in this case does not matter. However, according to scientists and doctors, some indicators of the material in the blood substance reach the highest level faster when the product is administered with food. Interaction with protein substances of the blood substance is up to 65%. The main part of the drug is removed from the body with the help of urine, 10% of the substance - along with bile.
Composition and form of release
Suprax Solutab is available in tablet form. The structure includes the dominant active chemical component - the cefixime compound. Also in the composition, auxiliary materials are observed in the form of povidone, cellulose, hyprolose, magnesium stearate and other products. Type of tablets - dispersible. The amount of cefixime in one element is 400 mg.
Indications for use
The drug is used for such diagnosed diseases: tonsillitis, inflammation of the pharynx, sinusitis, bronchitis in acute and severe forms, otitis media, some types of gonorrhea, infection of the urinary passages.
Side effects
After the introduction of Suprax Solutab, accidental reactions may occur. Most often they occur in the form of anorexia, diarrhea, nausea, jaundice, dysbacteriosis, flatulence, candidiasis of the digestive biosystem. Also recorded are glossitis, pseudomembranous type enterocolitis, dizziness, leukopenia, skin rashes, thrombocytopenia, anemia, neutropenia, eosinophilia, itching, some types of nephritis, fever. If such or other painful reactions occur when using Suprax Solutab, it is recommended to immediately cancel it and consult a doctor. Self-medication is dangerous. This can lead to severe disorders of both individual biosystems and the organism as a whole.
Contraindications
The drug is allowed to be taken by patients with various pathologies, because there are no special restrictions on taking the substance. Allocate the only prohibition associated with increased sensitization to some chemical components of the product.
Application during pregnancy
The use of pills during pregnancy is allowed only in rare cases when there is a real opportunity to improve the condition of the mother and not harm the fetus. Only an experienced medical specialist can prescribe Suprax Solutab after a thorough medical examination and analysis. clinical picture diseases. During breastfeeding of an infant, it is recommended to stop taking the drug, or vice versa. The antibiotic will harm the health of the baby.
Method and features of use
Antimicrobials are described by doctors as aggressive characteristics, which, if taken uncontrollably or with an incorrect treatment regimen, can provoke severe complications and the development of new pathologies. Therefore, the use of the drug Suprax Solutab is recommended to be administered only under the supervision of a doctor. If necessary, he will change the dosage, or prescribe another pharmacological agent. Tablets are prescribed to adults and minors who are already 12 years old. In this case, the teenager must weigh at least 50 kg. The norm of the drug is 400 m 1 time in 24 hours. The duration of the therapeutic effect is no more than 10 days. The instructions for the medication indicate the possibility of administering tablets to children under 12 years of age. In this case, the amount of the substance is determined individually, depending on the complexity of the course of the pathology and the characteristics of the organism. It is recommended to pay special attention to diseases provoked by Streptococcus pyogenes. Therapy is carried out for at least 10 days. Only such a treatment regimen can give a positive result. With caution, use the remedy for dysfunctions of the renal organization. If the patient's QC is from 21 to 60 ml / min, then the norm of the substance Suprax Solutab is recommended to be reduced by 25%. The same applies to patients undergoing hemodialysis. If a person has a CC parameter below 20 ml / min, and he is prescribed peritoneal type dialysis, then the amount of the substance must be reduced several times. Doctors recommend prescribing medicine to children who are not yet six months old from birth, with caution. Whether it is worth prescribing a medicine for people of advanced age, the doctor will indicate. He should also pay attention to the pathology of the kidneys, pseudomembranous colitis, if any, in a person. Before you start using the remedy, you must undergo a thorough medical examination. Suprax Solutab with prolonged administration leads to an upset of the intestinal section. Destructive processes that develop in the body contribute to the spread of Clostridium difficile. This causes severe diarrhea and pseudomembranous colitis. If an allergic reaction to a group of antibiotics related to penicillins is detected, it is better to stop taking the drug. According to some experts, the product is capable of leading to the appearance of direct Kumbus indicators and false indications of the reaction of urine to glucose.
Alcohol compatibility
Drinking alcohol with medical devices is dangerous. Especially serious complications are caused by the combination of alcohol with antimicrobials. In such cases, the latter may simply not be absorbed by the body and cause severe poisoning. The combination of Suprax Solutab and alcohol increases the load on the hepatic organ.
Interaction with other drugs
The drug is prescribed with caution along with other pharmacological agents. First of all, we are talking about blockers of tubular secretion. Their peculiarity lies in the delay in the removal by the renal organization of the main substance of the product - cefixime. If you take the product in combination with carbamazepine, then the volume of the latter in the blood substance may increase. Specialists observe the interaction of the drug together with indirect anticoagulants. In this case, the prothrombin index decreases. It is not advisable to administer Suprax Solutab together with antacids, which have a compound of magnesium and aluminum hydroxide in their structure. This is due to the ability of the latter to slow down the absorption of the antibiotic by the walls of the gastrointestinal tract.
Overdose
An overdose can occur when using an amount of the drug that exceeds the established norm. Most often, this leads to an increase in accidental reactions. When taking an overdose, you must consult a doctor. Therapy in this case is symptomatic. The patient's stomach is washed in order to remove unabsorbed tablets from the body. After that, the patient is prescribed antihistamines, glucocorticoids.
Analogues
The most popular pharmaceutical products that are used instead of Suprax Solutaba are Cefix, Sumamed, Tsemidiksor, Pancef. These products should only be prescribed by a medical examiner. Self-medication can cause serious complications. Children are most often prescribed Ceforal.
Terms of sale
Tablets are sold only with a prescription.
Storage conditions
Instructions for use indicate the features of saving funds. He is kept in a place to which there is no access to minors, sunlight. Temperature regime - not higher than 25°C. Shelf life - no more than 3 years from the date of issue.
Currently, the antibiotic Suprax is available in two varieties, which are called Suprax and Suprax Solutab. In fact, these two varieties of the drug differ from each other only in names and forms of release, and there are no more differences between them, since they contain the same active substances, and they also have the same indications, contraindications and application rules. That is why both Suprax and Suprax Solutab are often combined at the household level under one common name "Supraks". In the further text of the article, we will do the same, and under the general name "Supraks" we will mean both varieties of the same drug. We will indicate a specific dosage form and its name only in the case when it will be necessary to focus on any features of these varieties.In general, it can be tentatively assumed that different names were given to different dosage forms of the same drug for commercial reasons. It is more convenient for manufacturing firms from the point of view of commercial interests to sell the same drug under different names.
So, Suprax is available in three dosage forms:
- Dispersible tablets (under the commercial name Suprax Solutab);
- Capsules for oral administration (under the commercial name Suprax);
- Granules for the preparation of a suspension for oral administration (under the commercial name Suprax).
Capsules are produced under the name "Supraks", they are oblong cylinders, consisting of a white body and a purple cap. On the surface of the capsules there is an inscription "H808", applied with food grade ink. The inside of the capsules contains a mixture of powder and small granules, colored yellowish-white. Capsules are available in packs of 6 pieces.
Granules for suspension preparation for oral administration are produced under the name "Supraks", they are small balls, painted in white or cream color. The finished suspension, obtained after dissolving the granules in water, is white or cream colored and has a sweet strawberry aroma. The granules are produced in dark glass bottles, which are accompanied by a dosing spoon or a dosing syringe for measuring the required amount of the finished suspension. The vials contain 30.3 - 35.0 g of granules, which, when dissolved, give a suspension with an active substance concentration of 100 mg per 5 ml, or 20 mg per 1 ml.
The composition of all dosage forms of Suprax as an active ingredient includes the same substance - cefixime. Cefixime is included in the finished medicine not in pure form, and in the form of salt - cefixime trihydrate, because this ensures that it passes through the aggressive environment of the stomach undestroyed, and the release of the most active substance in the intestine, from where it is absorbed into the bloodstream.
Each tablet contains 447.7 mg of cefixime trihydrate, and each capsule contains 466 mg, which corresponds to 400 mg of pure cefixime. Accordingly, both tablets and capsules of Suprax have the same dosage - 400 mg. Because of this, they are often colloquially referred to as Suprax 400. Previously, capsules with a dosage of the active substance of 200 mg were also on sale, but these are currently not available.
The granules of one vial contain 1.402 g of cefixime trihydrate, which corresponds to 1.2 g of pure cefixime. This amount of antibiotic allows you to create a concentration of the active substance cefixime in the finished solution of 100 mg per 5 ml (20 mg per 1 ml). The amount of pure cefixime in 5 ml of the prepared solution (100 mg) corresponds to 116.83 mg of cefixime trihydrate.
The composition of the excipients of tablets, capsules and granules is given in the table:
| Excipients tablets Suprax Solutab | Excipients capsules Suprax | Auxiliary substances of Suprax granules |
| Silicon dioxide, colloidal | sodium benzoate | |
| Povidone | xanthan gum | |
| magnesium stearate | strawberry flavor | |
| Calcium saccharinate trisesquihydrate | Butanol | sucrose |
| Strawberry Flavor PV4284 | Titanium dioxide | |
| Dye "yellow sunset" | Gelatin | |
| Microcrystalline cellulose | Isopropanol | |
| Low-substituted hyprolose | carmellose calcium | |
| Dye Azorubine | ||
| Indigo carmine dye | ||
| sodium hydroxide | ||
| propylene glycol | ||
| Shellac | ||
| ethanol | ||
Therapeutic action
Suprax has an antibacterial effect, destroying pathogenic bacteria. It is a broad-spectrum antibiotic, as it is detrimental to a large number various kinds pathogenic bacteria. The destructive effect of Suprax for bacteria is due to its ability to disrupt the synthesis of the cell wall of pathogenic microbes, without which they simply cannot exist. Along with the destructiveness of Suprax for bacteria, the drug is also safe for the human body, so it can be used to treat children from the age of six months.Thanks to antibacterial action, Suprax leads to recovery from infectious diseases various bodies and systems if they are caused by bacteria sensitive to the effect of the antibiotic.
Suprax is resistant to the action of beta-lactamases - special substances produced by bacteria to protect against antibiotics. Many antibiotics that are unstable to the action of beta-lactamases are ineffective against bacteria that produce these substances. Therefore, Suprax is considered a highly effective antibiotic, to which bacteria that produce beta-lactamase do not develop resistance.
Suprax has a detrimental effect on the following types of pathogenic and opportunistic bacteria:
- Citrobacter amalonaticus;
- Citrobacter diversus;
- Escherichia coli;
- haemophilus influenzae;
- Haemophilus parainfluenzae;
- Klebsiella pneumoniae;
- Klebsiella oxytoca;
- Moraxella (Branhamella) catarrhalis;
- Morganella morganii;
- Neisseria gonorrheae;
- Proteus vulgaris;
- Proteus mirabilis;
- Pasteurella multocida;
- Providence spp.;
- Streptococcus agalactiae;
- Streptococcus pneumoniae;
- Streptococcus pyogenes;
- Salmonella spp.;
- Shigella spp.;
- Serratia marcescens.
- Bacteroides fragilis;
- Clostridium spp.;
- Enterococcus (Streptococcus) group D;
- Enterobacter spp.;
- Listeria monocytogenes;
- Pseudomonas spp.;
- Staphylococcus spp.
The effectiveness of taking Suprax once a day with various diseases, according to studies by clinical pharmacologists in Hungary, is as follows: - Pneumonia (pneumonia) - 90.9%;
- Tonsillopharyngitis - 92.6%;
- Exacerbation of chronic bronchitis - 72.2%;
- Sinusitis in children - 97.8%;
- Otitis media in children - 96.0%;
- infections urinary tract – 95,0%.
Indications for use
Suprax and Suprax Solutab are indicated for the treatment of the same following infectious and inflammatory diseases of various organs caused by antibiotic-sensitive bacteria:- Pharyngitis;
- tonsillitis;
- sinusitis;
- Acute and exacerbation of chronic bronchitis;
- otitis media;
- Urinary tract infections (cystitis, urethritis, pyelonephritis, cystourethritis);
- Gonorrhea;
- Shigellosis.
Instructions for use
Suprax suspension - instructions for use
Suprax is produced and sold in the form of granules intended for the preparation of a suspension that is taken orally. The finished suspension can be used to treat adults and children older than six months. For young children, it is the suspension that is the optimal dosage form of Suprax. Before use, the granules in the vial should be dissolved to form a suspension. The granules should be dissolved only when it becomes necessary to take Suprax, since the finished suspension is stored for only two weeks (14 days). After two weeks, the suspension, even if it has not been completely used up, must be discarded. And if for some reason you need to continue taking Suprax for longer than 14 days, you will have to make a new suspension by diluting the granules in the vial with water. In the form of granules, the drug is stored for a long time, and can be used until the expiration date indicated on the package.
How to dilute Suprax suspension?
To prepare the suspension, turn the vial upside down and shake its contents well. Then you need to open the lid and add 40 ml of chilled boiled water to the bottle in two stages. That is, you should first pour 20 ml of water into the bottle, wait a bit, and then pour another 20 ml. After that, it is necessary to shake the contents of the bottle well and put it on a table or other horizontal surface for 5 minutes so that the granules dissolve well and the foam formed during mixing settles. When the foam settles, you need to carefully see if the liquid level reaches the mark in the form of an arrow on the bottle label. If the liquid level does not reach the arrow, then you should carefully add a little more water to the bottle so that it reaches the mark. After that, the suspension is considered prepared and ready for use.
You can pour water into the bottle without first measuring 40 ml, but simply bringing its level to the mark. However, this can only be done if a person has experience in filling any containers to the marks applied to them. After all, if water is poured above the mark, the solution will have to be thrown away, since its concentration will be incorrect and unsuitable for treatment.
It is most convenient to measure the required amount of water to dilute the suspension or pour it immediately into the vial using a conventional syringe with a volume of 20 - 25 ml.
Ready diluted suspension should be stored at a temperature of 15 - 25 o C for no longer than 14 days. During storage, the suspension must not be allowed to freeze. If the suspension is frozen, then it should be discarded, and to continue treatment, prepare a new one from another bottle.
How to take the suspension?
After dilution, the suspension can be used within 14 days. Shake the suspension vial well before each use. To measure the required amount of suspension, you can only use the dosing spoon or dosing syringe supplied with the kit. Do not use other means, devices and containers (syringes, spoons, pipettes, etc.) to measure Suprax suspension.
Suprax suspension in the right amount should be swallowed and, if necessary, washed down with a small amount of water (for example, if a subjectively unpleasant aftertaste remains in the mouth). The suspension should be drunk directly from the dosing spoon or dosing syringe, without pouring the drug into other containers. After the suspension is drunk from a spoon or syringe, they should be washed with running water and detergent. Suprax suspension can be taken regardless of the meal, that is, at any convenient time.
For various diseases in which the use of Suprax is indicated, the drug is used in the same dosages, which are determined only by the age of the person, and do not depend on the type, location and nature of the infection. So, adults and adolescents over 12 years old weighing more than 50 kg should take Suprax 200 mg (10 ml suspension) twice a day, or 400 mg (20 ml suspension) once a day.
For children aged 6 months - 12 years, the dosage of the suspension is calculated individually, depending on body weight, based on the ratio: 8 mg per 1 kg of body weight per day. The calculated dosage can be given to the child completely once a day, or divided in half into two doses per day. For example, if the child's body weight is 10 kg, then the dosage of Suprax for him is 8 mg * 10 kg = 80 mg. Next, we calculate how many milliliters of the suspension contains 80 mg of the active substance. It is easy to calculate this, knowing that 1 ml of the suspension contains 20 mg of the active substance. This means that you need to divide the amount of mg calculated by the weight of the child's body by 20, and the final number will become the number of milliliters of suspension that should be given to the baby. In our example, 80 mg corresponds to 4 ml of suspension (in 1 ml of suspension 20 mg, so 80 mg is contained in 80 mg / 20 mg = 4 ml). This means that a child weighing 10 kg should be given Suprax 4 ml once a day, or 2 ml twice a day.
On average, for children aged 6-12 months, the daily dosage of the suspension is 2.5-4 ml, for children 2-4 years old - 5 ml, for children 5-11 years old - 6-10 ml. The daily dosage can be given at one time, or divided in half into two doses per day.
The dosage of Suprax is halved for children and adults on peritoneal dialysis or suffering from kidney disease with CC (creatinine clearance) less than 20 ml / min. For children and adults on hemodialysis or suffering from kidney disease with CC (creatinine clearance) equal to 21 - 60 ml / min, the dosage of Suprax is reduced by 25% (that is, by 1/4).
The duration of the course of application of Suprax is 7-10 days, but for infections caused by Streptococcus pyogenes (pyogenic streptococcus) - at least 10 days, and optimally - 14 days. Suprax should not be taken for less than 7 days, as this can lead to an incomplete cure and the formation of a variety of antibiotic-resistant bacteria. And this, in turn, will lead to the fact that after some time the untreated disease will definitely worsen again, but Suprax and other antibiotics of the cephalosporin group will be ineffective due to the fact that the bacteria have acquired resistance to the drug. In such a situation, other, even stronger antibiotics will have to be used.
People who have suffered from allergic reactions to antibiotics of the penicillin group in the past are highly likely to be allergic to Suprax. If a person has Lyell's syndrome, Stevens-Johnson syndrome or DRESS syndrome as an allergic reaction, then you should immediately stop taking Suprax and consult a doctor as soon as possible.
In addition, you should stop taking Suprax and immediately go to the hospital if acute renal failure or hemolytic anemia develops, since isolated cases of death from hemolytic anemia provoked by other antibiotics of the cephalosporin group have been described. If Suprax provoked hemolytic anemia, then in the future one should generally refrain from using antibiotics of the cephalosporin group, since the body can again react to any drug of this class with the development of anemia. Also, you should not start taking Suprax if in the past a person had an episode of hemolytic anemia in response to the use of antibiotics of the cephalosporin group.
During the period of application of Suprax, a positive direct Coombs reaction and a false-positive urine test for glucose are possible. It is better not to take these tests during the period of taking Suprax, since they are not accurate.
In case of an overdose of Suprax, it is not necessary to perform peritoneal or hemodialysis, since these methods do not accelerate the excretion of the drug from the body.
Interaction with other drugs
Simultaneous use with blockers of tubular secretion (Allopurinol, Probenecid, diuretics (Furosemide, Ethacrynic acid, Tobrasemide, etc.), penicillin antibiotics (Amoxicillin, Ampicillin, etc.), Phenylbutazone, etc.) leads to an increase in the concentration of Suprax in the blood, which can provoke an overdose of the latter.Suprax increases the concentration of carbamazepine in the blood while the use of these drugs.
Suprax reduces the value of the prothrombin index, thereby enhancing the effects of indirect anticoagulants (for example, Warfarin). Therefore, Suprax in combination with anticoagulants should be used with caution, constantly monitoring the INR or PTI to prevent the development of bleeding.
Antacids containing aluminum or magnesium hydroxides (for example, Maalox, Almagel) must be taken 4 hours before or 1 to 2 hours after taking Suprax, as they slow down and impair the absorption of the antibiotic into the bloodstream. And Suprax, respectively, should be taken 1 to 2 hours before or 4 hours after antacids.
Taking Suprax in combination with drugs that have a toxic effect on the kidneys (Polymyxin B, Colistin, aminoglycoside antibiotics (Gentamicin, Tobramycin, etc.), Viomycin, etc.), as well as with diuretics (Furosemide, Ethacrynic acid, etc.), increases the risk of developing kidney problems.
Suprax may reduce the effectiveness of oral contraceptives. Therefore, during the period of use and within a week after the completion of therapy with Suprax, barrier should be used in addition to oral contraceptives (yellowing of the skin, sclera of the eyes and mucous membranes);
Contraindications for use
Suprax and Suprax Solutab are contraindicated for use if a person has the following conditions or diseases:- Individual hypersensitivity or allergic reactions to antibiotics of the cephalosporin and / or penicillin groups;
- Individual hypersensitivity or allergic reactions to cefixime or any other auxiliary components of the preparations;
- Chronic renal failure in children under 18 years of age (for dispersible tablets Suprax Solutab);
- Violation of the kidneys, in which creatinine clearance (CC) according to the Rehberg test is less than 60 ml / min (for capsules);
- The body weight of a child or an adult is less than 25 kg (for dispersible tablets Suprax Solutab);
- Children's age under 12 years (for capsules);
- Children under six months of age (for granules for the preparation of a suspension for oral administration);
- Hereditary fructose intolerance, glucose and galactose malabsorption, sucrase and isomaltase deficiency (for oral suspension granules).
- Old age (over 65 years old);
- Chronic renal failure;
- Pseudomembranous colitis, suffered in the past.
Analogues
Currently, Suprax has two types of analogues on the domestic pharmaceutical market - these are synonymous preparations and, in fact, analogues. Synonyms for Suprax are medications, which also contain cefixime as an active ingredient. Actually analogues are drugs that do not contain such an active substance as that of Suprax, but have the most similar spectrum of therapeutic action. This means that the analogues of Suprax are antibiotics belonging to the group of cephalosporins (to which Suprax itself belongs). Synonyms of Suprax are the following drugs:
- Ixim Lupine powder for suspension for oral administration;
- Pancef granules for oral suspension, tablets;
- Cemidexor tablets;
- Ceforal Solutab dispersible tablets.
- Azaran powder for solution for injection;
- Axone powder for solution for injection;
- Bakperazon powder for solution for injection;
- Bestum powder for solution for injection;
- Betasporin powder for solution for injection;
- Biotriaxone powder for solution for injection;
- Broadsef-S powder for solution for injection;
- Vicef powder for solution for injection;
- Dardum powder for solution for injection;
- Intrataxim powder for solution for injection;
- Ificef powder for solution for injection;
- Kefotex powder for solution for injection;
- Klafobrin powder for solution for injection;
- Klaforan powder for solution for injection;
- Lendacin powder for solution for injections and infusions;
- Lifaxon powder for solution for injection;
- Liforan powder for solution for injection;
- Lorazidim powder for solution for injection;
- Lorakson powder for solution for injection;
- Medakson powder for solution for injection;
- Medocef powder for solution for injection;
- Movigip powder for solution for injection;
- Movoperiz powder for solution for injection;
- Operaz powder for solution for injection;
- Orzid powder for solution for injection;
- Oritax powder for solution for injection;
- Oritaxim powder for solution for injection;
- Oframax powder for solution for injection;
- Paktocef powder for solution for injection;
- Rezibelakta powder for solution for injection;
- Roceferin powder for solution for injection;
- Rocefin powder for solution for injections and infusions;
- Sefpotek tablets;
- Spectracef tablets;
- Stericef powder for solution for injection;
- Sulsoncef powder for solution for injection;
- Sulmover powder for solution for injection;
- Sulperazon powder for solution for injection;
- Sulperacef powder for solution for injection;
- Sulcef powder for solution for injection;
- Sulcephazone powder for solution for injection;
- Tax-o-bid powder for solution for injection;
- Talcef powder for solution for injection;
- Tarcefoxime powder for solution for injection;
- Tercef powder for solution for injection;
- Tizim powder for solution for injection;
- Torocef powder for solution for injection;
- Triaxon powder for solution for injection;
- Fortazim powder for solution for injection;
- Fortoferin powder for solution for injection;
- Fortum powder for solution for injection;
- Chizon powder for solution for injection;
- Cebanex powder for solution for injection;
- Cedex capsules and powder for suspension for oral administration;
- Tseperon J powder for solution for injection;
- Cetax powder for solution for injection;
- Cefabol powder for solution for injection;
- Cefaxone powder for solution for injection;
- Cefantral powder for solution for injection;
- Cefathrin powder for solution for injection;
- Cefzid powder for solution for injection;
- Cefzoxime J powder for solution for injection;
- Cefobid powder for solution for injection;
- Cefogram powder for solution for injection;
- Cefoperabol powder for solution for injection;
- Cefoperazone powder for solution for injection;
- Cefoperus powder for solution for injection;
- Cefosin powder for solution for injection;
- Cefotaxime powder for solution for injection;
- Cefpar and Cefpar SV powder for solution for injection;
- Cefson powder for solution for injection;
- Ceftazidime powder for solution for injection;
- Ceftidine powder for solution for injection;
- Ceftriabol powder for solution for injection;
- Ceftriaxone powder for solution for injection.
Suprax - analogues are cheaper
The following analogues are cheaper compared to Suprax:- Klaforan - the price for a bottle of powder is 160 - 200 rubles;
- Sulperazon - the price for a bottle of powder is 300 - 400 rubles;
- Fortum - price per bottle 200 - 600 rubles;
- Cefaxone - price per bottle 160 - 250 rubles;
- Cefantral - price per bottle 80 - 120 rubles;
- Cefobid - price per bottle 300 - 350 rubles;
- Cefosin - price per bottle 40 - 60 rubles;
- Cefotaxime produced in Russia, Belarus, Ukraine, China or India - the price per bottle is 20 - 40 rubles;
- Ceftazidime - price per bottle 75 - 160 rubles;
- Ceftriaxone produced in Russia, Belarus, Ukraine, China or India - the price per bottle is 20 - 40 rubles.
Instructions for use:
Suprax is a semi-synthetic antibiotic of the cephalosporin series for oral administration.
Pharmacological action of Suprax
Suprax is the first antibiotic among 3rd generation cephalosporins that can be taken orally. It is based on cefixime and has a wide spectrum of activity. The bactericidal mechanism of action of the drug is realized by inhibiting the formation of the main component of the cell wall of pathogens. Unlike previous generations of its counterparts, Suprax is resistant to beta-lactamases (bacterial enzymes that destroy the antibiotic, causing its action to become ineffective).
According to the instructions, Suprax inhibits the vital activity of gram-positive (various streptococci) and gram-negative (hemophilic and E. coli, Klebsiella, Proteus, Salmonella, Shigella, Serration, Citrobacter, Gonococcus) bacteria, but Pseudomonas aeruginosa, most types of staphylococcus, enterobacter and listeria are resistant to it.
The bioavailability of the antibiotic is 40 - 50%, food intake does not reduce it (as with other oral cephalosporins), but only slightly lengthens the time to reach the maximum blood level. Among all previous generations of Suprax analogues for oral administration, it has the longest half-life, so it can be taken once a day, which is very convenient, for example, for young children.
The drug Suprax penetrates well into the focus of infection - into the middle ear cavity, paranasal sinuses, tonsils, lungs, biliary tract.
With urine, 50% of the unchanged drug is excreted from the body, due to which it turned out to be highly effective in the treatment of urinary tract infections. About 10% of it is excreted in the bile.
When taken simultaneously with diuretics, the excretion of the drug slows down, its high concentration remains in the blood longer.
Suprax, according to reviews, has a slight inhibitory effect on the intestinal microflora compared to its counterparts.
Release form
Suprax is produced in two forms for oral administration - an adult (400 mg capsules) and a child (granules for the preparation of a strawberry-flavored suspension 100 mg / 5 ml - 60 ml).
Indications for use Suprax
According to the instructions, the drug is intended for the treatment of infections caused by microorganisms sensitive to cefixime. These are tonsillopharyngitis, sinusitis, otitis media, acute and chronic bronchitis, pneumonia, infections of the urogenital area (pyelonephritis, cystitis, uncomplicated gonorrheal urethritis and cervicitis). Suprax received good reviews in pediatric practice.
Contraindications
The antibiotic should not be used in case of intolerance and allergic reactions to it or other beta-lactam antibiotics (cephalosporins and penicillins), during breastfeeding (during treatment breast-feeding stop), in children under 6 months (no clinical studies).
With caution, the use of Suprax is possible in chronic kidney failure and in the elderly.
Method of application and dosage
The drug is taken 1 time per day inside. Before treatment, it is desirable to investigate the sensitivity of the pathogen to the antibiotic. Adults and children over 12 years of age are prescribed Suprax at a dose of 400 mg / day (1 capsule), an average course of 7 to 10 days, it is determined by the attending physician. In case of impaired renal function, the dose should be reduced.
For children, the dose is calculated by body weight - 8 mg / kg once a day or 4 mg / kg with an interval of 12 hours 2 times a day. There is a special children's form for them - a suspension with the taste of fresh strawberries. 1 ml of the finished suspension contains 20 mg of the drug.
6 months to 1 year daily dose Suprax according to the instructions 2.5 - 4 ml, from 2 to 4 years - 5 ml, from 5 to 11 years - 6 - 10 ml.
To properly prepare the suspension, you need to shake the granules in the bottle, pour 40 ml of cool water into it in 2 stages, shaking thoroughly each time until a homogeneous suspension is formed. In order for the granules to dissolve well, the finished suspension must be allowed to stand for a short time. Suprax suspension does not require refrigeration.
Suprax has a significant advantage over its analogues - it can be used to treat infections caused by fairly aggressive pathogens on an outpatient basis. The drug also supports the possibility step therapy when, due to the severity of the disease, treatment begins with parenteral forms of cephalosporins of the 3rd generation, and after 2-3 days, as the patient's condition improves, you can switch to oral intake Suprax.
Side effects of Suprax
According to reviews, Suprax during treatment can cause hives, itching, dry mouth, nausea, stomatitis, vomiting, diarrhea, abdominal pain, dizziness, headache. In the blood, the content of leukocytes and some biochemical parameters may change. Of the severe consequences of taking, anaphylactic shock, pseudomembranous colitis, interstitial nephritis are possible.
Produced in various forms. It is a 3rd generation semi-synthetic cephalosporin antibiotic. It inhibits the synthesis of the cell membrane, is resistant to the action of lactamases, which are produced by most bacteria.
Composition, release form, packaging
Capsules with a yellow cap and a former body of 200 mg each contain a mixture of granules and powder. The 400 mg capsules have a purple cap and a white body. The latter has the code H808.
Auxiliary substances are: silicon dioxide, magnesium, azorubine and carboxymethylcellulose. The shell is made from titanium dioxide, dyes and gelatin. One carton contains 6 capsules placed in a cellular blister pack.
Granules for the preparation of suspensions have 100 mg of active substance. Auxiliary substances are sodium benzoate, sucrose, flavor, yellow resin. Granules for the preparation of suspensions are produced in dark glass bottles of 60 ml.
Comes with a dosing spoon. After dilution, the suspension is almost white in color with a sweet strawberry flavor. In all forms, the main antibacterial agent is cefixime.
Manufacturer
The antibiotic is produced in Jordan by GEDEON RICHTER
Indications for use
Suprax is prescribed for diseases caused by bacterial infection. With its help, you can effectively cure:
- pharyngitis,
- sinusitis,
- sinusitis,
- and the flu
- tonsillitis,
- bronchitis.
The drug is suitable for the treatment of the genitourinary system. Effectively fights against uncomplicated forms of diseases. The effectiveness of the active component becomes higher if a bacterial culture is carried out in advance on the microflora.
Contraindications
The main group of contraindications includes hypersensitivity of the body to cephalosporin and penicillin group. With special care, it is prescribed for babies under 6 months old, the elderly, people with pseudomembranous colitis and. For capsules, contraindications are childhood up to 12 years old.
Mechanism of action
- multiform exudative.
Reactions from other systems are also possible: vaginitis, dysfunction of the urinary system, dysbacteriosis, jaundice, anemia, thrombocytopenia. On the part of laboratory indicators, there is an increase in the activity of hepatic transaminases, an increase in urea nitrogen, and an increase in prothrombin time.
To others side effects includes the development of hypovitaminosis B, the appearance of shortness of breath and.
Overdose
May increase with dose increase side effects, especially from the gastrointestinal tract. Treatment is carried out by washing, maintenance therapy. It should be borne in mind that peritoneal dialysis and hemodialysis are ineffective.
If necessary, glucocorticoids, pressor amines and transfusion of infusion solutions can be prescribed.
special instructions
Capsules and suspension can only be used if the intended benefit to the mother is greater than the risk to the fetus. During the period of taking the medicine, it is recommended to interrupt breastfeeding.
People who have allergic reactions to penicillins are hypersensitive to Suprax. Experts warn that when taking the drug, the balance may be disturbed normal microflora. The result is the growth of Clostridium difficile. This leads to diarrhea and pseudomembranous colitis.
drug interaction
Allopurinol, diuretics delay the excretion of cefixime by the kidneys. This increases the toxicity of the drug. Suprax reduces the prothrombin index and leads to an increase in the action of indirect anticoagulants. Preparations that contain magnesium, aluminum hydroxide can slow down the process of absorption of the drug.
In case of impaired renal function or in people on hemodialysis, the daily dose is reduced by 25%.
Compound
1 capsule contains: cefixime (in the form of trihydrate) 400 mg Excipients: colloidal silicon dioxide, magnesium stearate, calcium carmellose. The composition of the capsule shell: titanium dioxide, dye azorubine (E122), dye indigo carmine (E132), gelatin. Ingredients of food ink: shellac, ethanol, isopropanol, butanol, propylene glycol, sodium hydroxide, povidone, titanium dioxide.
Pharmacological effect
Semi-synthetic broad-spectrum cephalosporin antibiotic of the III generation for oral administration. Acts bactericidal. The mechanism of action is due to the inhibition of the synthesis of the cell membrane of the pathogen. Cefixime is resistant to β-lactamases produced by most Gram-positive and Gram-negative bacteria. In vitro and under conditions clinical practice cefixime is active against gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes; Gram-negative bacteria: Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, Escherichia coli, Proteus mirabilis, Neisseria gonorrhoeae. In vitro cefixime is active against gram-positive bacteria: Streptococcus agalactiae; Gram-negative bacteria: Haemophilus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia spp., Salmonella spp., Shigella spp., Citrobacter amalonaticus, Citrobacter diversus, Serratia marcescens. Pseudomonas spp., Enterococcus (Streptococcus) of serogroup D, Listeria monocytogenes, Staphylococcus spp. are resistant to the action of cefexim. (including methicillin-resistant strains), Enterobacter spp., Bacteroides fragilis, Clostridium spp.
Pharmacokinetics
Absorption and distribution: When taken orally, the bioavailability of cefixime is 40-50%, regardless of food intake, however, Cmax of cefixime in serum is reached faster by 0.8 hours when taking the drug with food. When taking the drug in the form of capsules, Cmax in the blood serum is reached after 4 hours and is 3.5 μg / ml. When taking the drug in the form of a suspension at a dose of 200 mg, Cmax in blood serum is reached after 4 hours and is 2.8 mcg / ml, when taken at a dose of 400 mg - 4.4 mcg / ml. Plasma protein binding, mainly albumin, is 65%. Excretion: About 50% of the dose is excreted in the urine unchanged within 24 hours, about 10% of the dose is excreted in the bile. T1 / 2 depends on the dose and is 3-4 hours. Pharmacokinetics in special clinical cases: In patients with impaired renal function with CC from 20 to 40 ml / min, T1 / 2 increases to 6.4 hours, with CC 5-10 ml / min - up to 11.5 hours.
Indications
Infectious and inflammatory diseases caused by microorganisms sensitive to the drug: Pharyngitis, tonsillitis, sinusitis. Acute and chronic bronchitis. Otitis media. Uncomplicated urinary tract infections. Uncomplicated gonorrhea.
Contraindications
Impaired renal function with CC less than 60 ml / min (for capsules), children under 12 years of age, hypersensitivity to cephalosporins and penicillins. Care should be taken to prescribe the drug to elderly patients, with chronic renal failure, pseudomembranous colitis (history).
Precautionary measures
With caution, the drug should be prescribed to elderly patients, with chronic renal failure, pseudomembranous colitis (in history).
Use during pregnancy and lactation
The use of Suprax during pregnancy is possible only if the intended benefit to the mother outweighs the potential risk to the fetus. If necessary, the use of Suprax during lactation should stop breastfeeding.
Dosage and administration
Adults and children over 12 years of age weighing more than 50 kg are prescribed the drug at a dose of 400 mg 1 time / day. In uncomplicated gonorrhea, 400 mg is prescribed once. The average duration of the course of treatment is 7-10 days. For infections caused by Streptococcus pyogenes, the course of treatment should be at least 10 days. For patients with impaired renal function with CC less than 60 ml / min, who are on hemodialysis or peritoneal dialysis, the drug should be administered in the form of a suspension for oral administration.
Side effects
Allergic reactions: urticaria, skin flushing, pruritus, eosinophilia, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), anaphylactic shock, reactions resembling serum sickness. nervous system headache, dizziness, tinnitus, convulsions. From the side digestive system dry mouth, anorexia, nausea, vomiting, diarrhea, constipation, flatulence, abdominal pain, dysbacteriosis, liver dysfunction, cholestasis, cholestatic jaundice, candidiasis, stomatitis, glossitis, pseudomembranous enterocolitis. From the hematopoietic system, pancytopenia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia, bleeding. On the part of the urinary system, interstitial nephritis, impaired renal function, acute renal failure. On the part of the reproductive system, vaginitis, itching of the genital organs. On the part of laboratory parameters, an increase in the activity of hepatic transaminases and alkaline phosphatase, hyperbilirubinemia, increased urea nitrogen, hypercreatininemia, increased prothrombin time. Other candidiasis, shortness of breath.
Overdose
Symptoms: increased manifestations of the described side effects, especially from the digestive system, with the exception of allergic reactions. Treatment: gastric lavage; carry out symptomatic and supportive therapy, which, if necessary, includes the use of antihistamines, GCS, epinephrine, norepinephrine, dopamine, oxygen therapy, transfusion of infusion solutions, mechanical ventilation. Cefixime is not excreted in large quantities from the circulating blood by hemo- or peritoneal dialysis.
Interaction with other drugs
Tubular secretion blockers (allopurinol, diuretics) delay the excretion of cefixime by the kidneys, which can lead to an increase in the concentration medicinal product in blood plasma. With the simultaneous use of cefixime and carbamazepine, the concentration of carbamazepine in the blood plasma increases. Reduces the prothrombin index, enhances the effect of indirect anticoagulants. Antacids containing magnesium or aluminum hydroxide slow down the absorption of the drug, so the drug should be used 1-2 hours before or 4 hours after taking these drugs.
special instructions
With prolonged use of the drug, a violation of the normal intestinal microflora is possible, which can lead to the growth of Clostridium difficile and cause the development of severe diarrhea and pseudomembranous colitis. Patients with a history of allergic reactions to penicillins may show hypersensitivity to cephalosporin antibiotics. During treatment, a positive direct Coombs test and a false positive urine test for glucose are possible. Patients with diabetes it must be borne in mind that the composition of the suspension includes sucrose: 15 g in 20 ml (400 mg). Influence on the ability to drive vehicles and control mechanisms: Patients taking cefixime should be careful when driving. vehicles and other potentially hazardous activities that require increased concentration and speed of psychomotor reactions, taking into account the profile of side effects.