Irunin in chronic thrush. Irunin pills for candidiasis

The drug "Irunin", produced in the form vaginal tablets and capsules for oral administration, is widely used to treat thrush. Itraconazole, which is part of it, effectively relieves the symptoms of the disease in the first days of therapy and prevents the occurrence of relapses. Despite the safety and gentle effect on the body, the drug has a number of side effects and contraindications, including pregnancy and lactation.

Irunin from thrush

"Irunin" is a broad-spectrum antifungal agent, produced in the form of vaginal tablets and capsules for oral administration. The drug is successfully used in the complex therapy of mycotic lesions. internal organs, skin and mucous membranes, as well as in gynecological practice for the treatment of thrush.

Description and form of release of the drug

The main active ingredient is itraconazole, a synthetic substance that destroys the cell membrane of pathogenic microorganisms and leads to their death. Active against yeast fungi of the genus Candida, as well as dermatophytes and molds.

vaginal tablets

The agent for intravaginal administration is available in the form of white ring-shaped tablets. The unique form of the drug facilitates the introduction and ensures its uniform distribution over the affected areas of the vaginal mucosa. Itraconazole acts locally, without getting into the internal bloodstream, absorption by tissues is practically absent. The main indication for use, including chronic, accompanied by frequent relapses.

Capsules for oral administration

"Irunin" for oral use is available in the form of capsules with a yellow gelatin shell containing white spherical pellets. The maximum concentration of the drug in the blood is reached approximately 4 hours after ingestion. The active substance accumulates in the skin and keratin of the nail plates, enters the tissues of internal organs colonized by pathogenic microorganisms.

The drug is metabolized by the liver with the formation of a number of substances with antifungal activity comparable to itraconazole. Completely excreted in urine and feces 3-4 weeks after completion of therapy.

Indications for the use of the drug in the form of capsules are:

fungal lesions of the skin, nails, cornea of the eye (keratitis);
systemic mycoses, accompanied by lesions respiratory tract, urinary organs and gastrointestinal tract;
pityriasis versicolor;
fungal infection of the oral cavity;

Method of application, contraindications and side effects

For the treatment of thrush, suppositories are most often used for insertion into the vagina. In severe recurrent course of candidiasis, as well as in the detection fungal infection skin and internal organs, simultaneous oral administration of the drug can be prescribed.

The exact dosage and duration of therapy is prescribed by the doctor based on the existing clinical picture.

Approximate scheme of application, as well as possible side effects and contraindications are given in the table:

Parameter	Release form
Parameter	Tablets for vaginal administration	Capsules for oral administration
Dosage per day	1 tablet
Duration of treatment	7 to 14 days	1 day	3 days
Mode of application	Insert deep into the vagina at night	Take after meals at the same time. Swallow without chewing and drink warm water
Side effects	Itching, burning, punctate rash on the external genitalia	constipation, nausea, dark urine, headache, dizziness, allergic reactions
Contraindications	Sensitivity to the substances that make up the product, pregnancy (I trimester), lactation	Sensitivity to the substances that make up the product, pregnancy, lactation, childhood up to 12 years, severe diseases of the liver and cardiovascular system

If any of the listed symptoms of side effects occur, the drug should be discontinued and the attending physician should be informed. In case of local reactions in the genital area, the vagina can be gently rinsed with boiled water.

Women of reproductive age during treatment with the drug should use adequate methods of contraception until complete recovery. The use of Irunin on early dates pregnancy can lead to its termination.

special instructions

At the time of using vaginal tablets for the treatment of thrush, sexual intercourse should be stopped and the partner should be treated simultaneously to exclude the possibility of re-infection. If a woman does not plan to give up intimate relationships, it is necessary to take care of reliable methods of protection, since itraconazole weakens the effect of some contraceptives.

Besides, active substance tends to accumulate in the body, so the onset of pregnancy in the menstrual cycle when the treatment was carried out is highly undesirable. With a possible conception, the drug will have a detrimental effect on the fetus, leading to severe deviations in its development.

During menstruation, the administration of suppositories is ineffective, so they should be replaced with oral capsules.

You should warn your doctor about the use of any medication while taking Irunin orally, as some drugs may reduce the activity of itraconazole. A similar effect also occurs when low acidity. In this case, it is recommended to drink antacids two hours before taking the capsules.

Overdose

There are no data on manifestations of overdose. If the number of prescribed capsules is exceeded or accidentally swallowed, it is necessary to wash the stomach and take activated charcoal or another adsorbent.

Comprehensive approach to treatment and prevention

In order for the use of antifungal agents to bring the desired result, the following recommendations must be observed:

do not overcool;
avoid stress;
follow a diet that excludes the use of pastries, sweets, canned food;
timely treat all infectious and inflammatory diseases;
refuse to wear synthetic underwear;
use pH-neutral gels for daily intimate hygiene;
conduct rehabilitation therapy after treatment of candidiasis.

To normalize the natural microflora of the vagina, you can use preparations based on lactic acid, for example, Gynocomfort or Lactagel. To strengthen general and local immunity, it is recommended to use suppositories "Viferon" or "Genferon" after prior consultation with a doctor.

Irunin tablets - an antifungal agent for local application in the field of gynecology. Below is an instruction for the use of this dosage form of the drug.

Composition and pharmacological action

The active substance is itroconazole (200 milligrams per tablet).

Itroconazole has an antifungal effect due to the fact that under its influence the cell membrane of pathogenic fungi becomes less durable and gradually collapses. This result is achieved due to the fact that itroconazole inhibits the production of ergosterol (a precursor of vitamin D2), which is an integral part of the fungal cell wall.

As excipients, Irunin contains the following components: milk sugar, Mg3C4O3, potato starch, sodium dodecyl sulfate, insoluble polyvinylpyrrolidone, stearic acid.

Analogues

Analogues of Irunin containing the same active substance (itraconazole) are the following drugs:

Itramikol;
(for pregnant);
Canditral;
Myconihol;
Orungamine;
Teknazol.

Release form

Irunin vaginal tablets are in the form of a ring. White or whitish. Are issued on 10 pieces in cardboard packing.

In addition to vaginal tablets, there is such a dosage form of Irunin as capsules for oral (oral) use. It is released from pharmacies by prescription. The average price of Irunin in Russia is 315 rubles per package (10 tablets).

Indications for use

Irunin in the form of tablets is prescribed for the treatment of vulvovaginal candidiasis (thrush) of varying severity. Including effectively helps with recurrent thrush.

Instructions for use

Irunin tablets are intended for intravaginal use.

The description below explains how to take Irunin tablets for thrush.

The duration of the course of treatment is usually 1-2 weeks. If necessary, the doctor may prescribe repeated courses of treatment.

To prevent relapse, sexual partners should be treated at the same time, refrain from sexual intercourse for the duration of the course of treatment and observe personal hygiene.

Contraindications

Treatment with the drug Irunin tablets is contraindicated in the presence of the following conditions:

intolerance to the active substance and / or auxiliary components of the drug;
first trimester of pregnancy and lactation.

Use with caution and exclusively under the supervision of a specialist during the second and third trimesters of pregnancy.

If necessary, the use of the drug during lactation should stop breastfeeding.

Drug interaction of Irunin vaginal tablets with other drugs has not been identified.

Cases of overdose with intravaginal use have not been recorded. Excessive oral use dosage forms intended for oral use does not threaten the life and health of the drug.

If a tablet intended for intravaginal use is accidentally swallowed, flush the stomach with warm water or weak solution baking soda, then take some enterosorbent (for example, activated charcoal).

Side effects

With intravaginal use, local allergic reactions may occur - rashes, discomfort in the vagina (itching, burning).

Expert opinion

Dermatologist Shcherban A.V.:

A very effective antimycotic agent. I usually prescribe for systemic therapy, most often for onychomycosis (except for distal, that is, onychomycosis of the free edge of the nail). Of course, it has contraindications and side effects, but this is normal for antimycotics of this kind. So Irunin fully justifies its price.

"Irunin" is a modern systemic drug with antifungal activity. IN international classification The drug is called Itraconazole. It is used for many diseases that are caused by a fungus. What features of the reception indicate instructions for the use of "Irunin"?

1 Composition and action of the drug
2 Indications
3 When the product should not be used
4 Instructions for use "Irunina"
5 Side effects
6 Analogues
7 Special instructions
8 Reviews: "By the third day, the spots on the skin are almost gone"

The range of antifungal drugs is large. But many of the microorganisms are able to acquire resistance to the action of drugs. Especially with regular use. The described drug is highly effective in the treatment of not only candidiasis, but also other fungal diseases. And the reviews about Irunin confirm this.

The composition and action of the drug

"Irunin" is produced in capsules and vaginal tablets (not in suppositories). The main active ingredient is itraconazole, the content of which in the composition of the capsule form is 100 mg and 200 mg in tablets. The characteristics of the forms are as follows.

hard capsules. They are made of gelatin, their color is yellow, inside they contain spherical white pellets. Available in packs of ten. Auxiliary components of this form of release are eudragit, nipazole, sucrose, titanium dioxide, nipagin, dyes, starch syrup.
vaginal tablets. Ring-shaped, white, ten pieces per pack. Their additional components are: milk sugar, talc, starch, magnesium stearate, povidone, sodium lauryl sulfate.

Itraconazole has a detrimental effect on fungal cells. Penetrating inside the pathogen, it slows down the production of ergosterol, a specific enzyme, by its membrane. This contributes to the destruction of pathogenic fungi, and they do not spread throughout the body.

The features of the drug include the following:

The following types of fungal microorganisms are most sensitive to the drug component:

molds and yeast fungi- candidiasis, aspergillus, blastomycetes;
dermatomycetes- trichophyton, microsporia.

Indications

The capsule form of the drug is widely prescribed for systemic diseases. Indications for the use of "Irunin" are the following situations:

complex therapy- fungal infections;
prevention of dysbacteriosis- against the background of taking medications;
mycoses- body and head skin hairy part), with seborrhea and eczema, as well as cryptococcosis;
lichen- is prescribed for shingles, multi-colored (pityriasis), ringworm;
candidiasis- in which mucous membranes are affected, as well as deep visceral candidiasis with damage to internal organs, systemic aspergillosis and candidiasis;
onychomycosis- nail fungus;
prostatitis- fungal nature.

"Irunin" in the form of vaginal tablets is used for vulvovaginal candidiasis. And not only for the treatment of the acute form of the disease, but also for recurrent thrush.

When the tool cannot be used

Not everyone can take medicine. The table shows the relative and absolute contraindications for admission.

Table - Conditions in which treatment with "Irunin" is undesirable or prohibited

It is imperative to inform the doctor about the use of any other medicines, since Irunin may not be combined with some of them.

During drug therapy, women of childbearing age should take care of barrier contraception. During pregnancy, Irunin should be taken exclusively as part of the treatment of systemic fungal infections and only in the second and third trimesters. In this case, the reception should be agreed with the doctor, since the medicine increases the risk of fetal abnormalities.

Instructions for use "Irunin"

For maximum effect, the capsule form should be taken with meals or immediately after, swallowing whole. The duration of treatment and the frequency of administration depend on the specific disease and are determined individually in each case. The main treatment regimens are presented in the table.

Table - Features of the course of treatment with "Irunin" for various diseases

Pathology	Dosage "Irunina" and features of its reception
Lichen	2 capsules in 1 dose per day for 7 days
Mycosis of smooth skin	- 2 capsules in 1 dose per day for 7 days; - with lesions of the feet and hands, 100 mg for 15 days
Oral candidiasis and intestinal fungus	1 capsule per day for 14 days
Fungal keratitis	2 capsules in 1 dose per day for 21 days
Aspergillosis	- 2 capsules 1-2 times a day (depending on the form of the disease); – treatment lasts from 1 to 5 months
Onychomycosis	Option number 1 (pulse therapy): - 2 capsules 2 times a day for 1 week, followed by a break of 3 weeks; - in case of damage to the feet, such 3 courses are carried out, brushes - 2
Onychomycosis	Option number 2 - continuous medication 2 capsules 1 time per day for 3 months

The optimal effect of the treatment can be observed after 6 months for nail lesions and two to four weeks for skin mycoses.

Intravaginal use of tablets is indicated for vulvovaginal candidiasis. The drug (200 mg) is injected into the vagina at bedtime. The duration of treatment is one to two weeks. With menstruation, you should stop treatment or switch to taking the drug orally. Thrush can be treated by taking capsules orally. For this, 100 mg is taken twice a day for two to three days.

Side effects

When using Irunina capsules, patients may experience side effects drug. The main ones are shown in the table.

Table - Complications of the internal reception of "Irunin"

body system	Complications
Nervous system	- Dizziness; - severe fatigue; - cephalalgia; - sometimes peripheral neuropathy
Digestive organs	- Nausea; - discomfort in the abdomen; - vomit; - cholestatic jaundice; - dyspepsia; - constipation; - described cases of toxic hepatitis with the development of liver failure
reproductive system	Dysmenorrhea
The cardiovascular system	- Heart failure; - pulmonary edema
From the side of the skin	- Rash; - hair loss; - itching; - urticaria; - angioedema
Exchange disorders	- Hypokalemia; - edema
urinary system	- Increases creatinine, while the urine becomes dark

As a result of the use of vaginal tablets, local reactions are sometimes observed in the form of mild itching and burning in the vagina, rashes on the genitals. In this case, you should not interrupt treatment with the drug if the symptoms do not progress, but disappear.

Analogues

There are many analogues of the drug. Some of them:

"Mycomax"- antifungal drug in capsules, the active substance is fluconazole;
"Mikoflukan"- a systemic antimycotic agent, which contains fluconazole;
"Rumikoz"- the budget analogue of "Irunin", is available in capsules, the active substance is itraconazole 100 mg each;
Itrazol- capsules, based on 100 mg of itraconazole.

Other agents based on itraconazole are also known. For example, Orungamine, Orungal, Itramikol. But the decision to replace one drug with another should be made only by a doctor.

special instructions

Increase the dose is sometimes necessary for patients in whom the immune system is provoked. For example, there is neutropenia, HIV infection, a condition after organ transplantation.
It is undesirable to take the remedy for patients with kidney, liver, heart failure. Exceptions are cases where the expected effect is higher than the likelihood of possible complications.

Liver function should be monitored while taking the medicine once a month.
When using the vaginal form of the drug, you need to refrain from sexual intercourse and simultaneously treat two partners.

Features of interaction with other drugs are as follows:

reduce the effect- "Rifampicin", "Difenin", "Carbamazepine", "Phenobarbetal";
enhance the effect- "Erythromycin", "Ritonavir".

The compatibility of "Irunin" with alcohol is doubtful, since this increases the load on the liver. You should refrain from taking alcoholic beverages for the duration of treatment.

The widespread use of "Irunin" in dermatological and gynecological practice has proven its effectiveness and good tolerance. IN official instructions there is no data on a possible overdose of the drug, the doctors' reviews also do not contain such information. If, nevertheless, a large dose of the drug was taken, it is necessary to wash the stomach for an hour and take activated charcoal. Held symptomatic treatment. There are no specific antidotes.

Reviews: “On the third day, the spots on the skin almost disappeared”

I, too, was cured with Irunin according to the pulse therapy scheme (there is one in the instructions), exoderil dripped onto the cleaned nail and some other antifungal ointment ... The nail slowly grew healthy, ... otherwise it was such a deep fungus that even the sensitivity on thumb gone...

the guest, http://www.woman.ru/health/medley7/thread/3943641/2/

For 2 years, with periodic success, she struggled with multi-colored lichen. Chatterboxes helped only for a while. On this basis, she lived to a neurosis. The last conclusion of the dermatologist is seborrheic dermatitis, weeping. I started taking Irunin in combination with vitamins, sedatives and linden tea. On the third day, almost all spots on the skin disappeared (even the tightness of the skin disappeared), itching and dandruff still remained, but there was hope for healing .. I hope for positive results, but for now I continue the treatment ....

Olga

Treated fingernails affected by fungus different ways about 5 years. On the recommendation of a doctor, I tried Irunin. After 2 courses (14 tablets each), the nails were completely cleansed. The industries are new and there have been no problems for 5 years. I read about the side effects in the instructions, but nothing happened.

Yuri, http://www.tiensmed.ru/news/irunin-a2h.html

When I was examined by a gynecologist, she prescribed Irunin for candidiasis. I took Irunin 2 capsules 2 times a day after breakfast and dinner. She was treated for 3 days in total. During the course, the symptoms practically disappeared. But literally three days after the end of treatment, they began to resume. I didn’t have a sexual partner then, so the infection option is no longer possible. Looks like I just threw money away. Later I read that he still has a long list of side effects, but, fortunately, they did not appear in me. I will not argue that the drug is completely useless, but for me personally, it turned out to be just that.

Lora

Three years ago, the eldest son found spots of multi-colored lichen. For a whole month they tried to cure him with various gels and ointments. In the end, they were examined by a dermatologist, and he advised antifungal tablets to choose from. I decided to buy Irunin, because it was the most inexpensive (only 300 rubles per pack). In comparison with Orungal, which costs 2,000 rubles, these are pennies. I gave my son two capsules after breakfast for three days, as recommended in the instructions. The son tolerated the drug normally, there were no side effects, at least visible ones. On the third day, the lichen began to go away, and after 10 days only a trace remained.

Spring, http://doctorsforum.ru/viewtopic.php?f=32&t=427

"Irunin": treatment regimens and effectiveness for fungus - everything about and for health on KrasotaDiet.ru

The human body is a fairly complex mechanism that has the ability to independently protect itself from the influence of external stimuli. IN modern world there are many microorganisms, representatives of conditionally pathogenic flora, which are capable of destroying the protective barriers of the body at any convenient time for them, start accelerated growth and reproduction, and cause the development of various ailments, most often mycoses.

Of course, fungal infections do not pose a great danger to humans, but still, in the absence of timely treatment, they can contribute to the development of various complications that negatively affect well-being and health in general.
Mycosis - diseases of the skin, internal organs, hair. The causative agents of mycoses are opportunistic fungi. To suppress their number, the treatment of unpleasant ailments caused by them, the drug Irunin has been developed. Therefore, we will consider its features, indications, contraindications, and many other important points.

Irunin: general characteristics

The main active ingredient of this drug is itraconazole. It has a detrimental effect on the fungal flora, leads to the death of fungi. Itraconazole will be active against infections caused by yeast-like microorganisms Candida albicans, Candida krusei, Candida giabrata, Blastomyces dermatitidis, Histoplasma spp., Cladosporium spp., dermatophytes Microsporum spp., Trichophyton spp., many other molds, yeast fungi. The concentration of the drug is maintained in skin within 14-30 days after the completion of the course of treatment, and in the woman's vagina, the concentration will remain for a couple of days after a three-day therapy. Removal of Irunin occurs with urine, with feces.

Indications

Irunin is very often prescribed for the treatment of vulvovaginal thrush in women. Thrush is a common disease among women, provoked by yeast fungi of the genus Candida. Its main cause is the weakening immune system against the background of negative factors. For example, malnutrition, stress, fatigue, serious illnesses, any inflammatory processes. Thrush also often worries women, due to overheating, hypothermia, during pregnancy, before menstruation. It is manifested by severe itching of the genitals, burning after taking a shower, washing, urinating, secretions similar to curdled mass. To start therapy, you need to consult a doctor, undergo an examination, and then proceed with the implementation of all recommendations. Irunin for the treatment of thrush is prescribed in the form of vaginal suppositories. Among other indications for the use of this tool are:

Onychomycosis provoked by yeast fungi, dermatophytes.
Dermatomycosis.
Pityriasis versicolor.
Systemic mycoses, for example, histoplasmosis, cryptococcosis.
Thrush (candidiasis) with lesions of the mucous membranes, skin.
Fungal keratitis.

For whom is Irunin contraindicated?

Almost all medicinal drugs have contraindications for use in their arsenal. These also include Irunin. It is forbidden to use it in the presence of hypersensitivity to certain components of the drug, with kidney diseases, with liver failure, various pathological conditions of the liver, at the age of less than 16 years. In addition, the list of contraindications includes chronic or acute heart failure, the first three months of pregnancy. With regards to the second and third trimesters of pregnancy, Irunin is prescribed only in case of emergency, as prescribed by the attending doctor, if the risk of use is justified by the benefit to the woman.
During lactation, this medicine is not prescribed, since it has the ability to be absorbed into mother's milk, albeit in small quantities. Therefore, for the period of treatment, breastfeeding is stopped.

Side effects

All drugs can have their own side effects on the human body. Consider the situation with Irunin. It can cause constipation, nausea, abdominal pain, dyspeptic disorders, headaches, weakness, fatigue.
In addition, in some cases it provokes a rapid decrease in body weight, up to anorexia, the occurrence of hepatitis.
If speak about cardiovascular system, other systems, organs, the drug can show side effects in the form of pulmonary edema, heart failure, hypokalemia, allergies (urticaria, skin itching), disorders menstrual cycle, change in color of urine to darker.

Application features

Consider the list of drugs that are forbidden to be taken in parallel with itraconazole. These include:

Cisapride;
Simvastatin;
Quinidine;
Terfenadine;
Mizolastin;
Lovastatin;
many other.

In addition, with simultaneous treatment with calcium channel blockers, as well as itraconazole, one must be extremely careful, since the metabolism of these blockers can be significantly impaired. All doctors should remember this before prescribing a medicine.

Candles Irunin for the treatment of thrush

If a doctor diagnoses a woman with a disease such as thrush, he can prescribe Irunin as an antifungal drug that will have a detrimental effect on the causative agents of the disease. Often medicines in the form vaginal suppositories come to the rescue in the course of an acute form of the disease. If therapy is started on time, it will be possible to avoid the transition to the chronic stage, the development of all kinds of complications from thrush.

How to use candles for thrush? It is necessary to insert one candle into the vagina every day before going to bed. It is important to note that you should enter as deeply as possible. During the night, the medicine will dissolve in the vagina, evenly distributed over it, and will gradually destroy pathogens. The duration of therapy for thrush can be a maximum of 14 days.

Irunin tablets

If we are still talking about genital thrush in women, Irunin tablets are most often prescribed to enhance the effect of local therapy in chronic forms of candidiasis, with a complex course of the disease. Acute thrush is rarely treated with pills. The drug in this form is prescribed only if there is a need for it. He prescribes medicine, only the doctor prescribes specific doses!

Tablets are used to treat dermatomycosis, systemic mycoses, and other diseases listed in the paragraph with indications for the use of Irunin.

Analogues

The modern pharmacology market offers a number of medicines, which are analogues of Irunin. These include:

Orungal;
Itrazol;
Orungamine;
Orunite;
Itraconazole;
Rumikoz.

Prevention

Before starting the treatment of any disease, we recommend contacting specialists, being examined, and fulfilling all their appointments. The occurrence of thrush can always be prevented. To do this, you should balance the diet, include more fruits, vegetables, dairy products. We must not forget about the use of cereals, meat, fish, nuts. Prevention measures also include sports, an active lifestyle, and the absence of stress. To avoid thrush, you need to rest enough, not overheat, avoid hypothermia, be sure to observe hygiene.
Do not get sick, be healthy!