Platifillin instructions for use percentage. Does platifillin prick intramuscularly

Platifillin (form - solution) corresponds to the group of drugs for the treatment of functional disorders of the gastrointestinal tract. In the instructions for use, the following features of the drug are distinguished:

• Sold by prescription only
• During pregnancy: contraindicated
• When breastfeeding: contraindicated
• IN childhood: carefully
• With impaired liver function: with caution
• In case of impaired renal function: with caution

Package

Composition

1 ampoule contains 1 ml of a clear, colorless solution intended for injection, platyfillin hydrotartrate (2 mg). As an auxiliary substance - distilled water for injection.

One tablet contains platyfillin hydrotartrate weighing 0.005 g plus papaverine hydrochloride 0.02 g. The list of excipients includes: potato starch, calcium stearate, sugar, talc.

Release form

The cardboard box contains 5, 10 ampoules.

The combined product with papaverine is available in the form of white tablets - 10 pcs. in blisters.

pharmachologic effect

The drug has a sedative, antispasmodic, vasodilating (vasodilating) effect.

Pharmacodynamics and pharmacokinetics

Platyphylline is an international name (INN) that has been accepted for use in the UK (BAN). Platifillin is a pyrrolizidine alkaloid found in plants of the genus Senécio. The active substance of the drug is used in the form of hydrotartrate, a Latin prescription for the substance Platyphyllini hydrotartratis, which can inhibit the choline-reactive system, which transmits excitation from the parasympathetic nerves to the executing organs, thereby having a calming effect on the vasomotor center, blocking the N-cholinergic receptors of the autonomic ganglia much weaker.

The drug has an anticholinergic dose-dependent effect, that is, smaller doses inhibit the secretion of the salivary and bronchial glands, sweating, eye accommodation, causing pupil dilation, an increase in heart rate, while large doses reduce the contractile activity of the alimentary tract, including the biliary tract and gallbladder, Besides - urinary tract and inhibits gastric secretion.

With regard to pharmacokinetics, Platifillin can easily pass through histohematological barriers, including hematoencephalic, cellular and synaptic membranes. Correct Dosage and intervals of administration do not cause cumulation of the drug, however, the administration of large doses causes its accumulation in the tissues of the central nervous system in significant concentrations. Metabolized in the liver and eliminated in the kidneys and intestines.

Indications for Platifillin's use

Used for:

• spasm of smooth muscles internal organs(pylorospasm, intestinal, renal or biliary colic);
• with stomach ulcers and duodenum;
• cholecystitis or cholelithiasis;
• with acute pancreatitis or other chronic types;
• with bronchial asthma or laryngospasm;
• at arterial hypertension, angina pectoris, spasms of cerebral arteries and angiotrophoneurosis as part of combination therapy.

For diagnostic purposes, Platifillin is used to dilate the pupil, in the study of the fundus, in determining the true refraction of the eye, acute inflammatory diseases x eyes, inflammation of the iris, keratitis and other eye injuries.

Contraindications

Cannot be used for glaucoma coronary disease heart, thyrotoxicosis, cardiac, hepatic or kidney failure, as well as in the presence of hypersensitivity to Platifillin.

Side effects

Dry mouth and thirst, difficulty urinating or urinary retention, paresis of accommodation (ciliary muscle of the eye), CNS excitation, dizziness, dilated pupils, headaches, convulsions, photophobia, acute psychosis, from the side of the cardiovascular system - tachycardia. Among other things, the appearance of atelectasis of the lung is possible.

The likelihood of adverse reactions increases with high doses of Platyfillin.

Application instruction of Platyfillin (Way and dosage)

It is necessary to apply parenterally (subcutaneously, intramuscularly), rectally, in ophthalmology - locally.

Platyfillin injections, instructions for use

Apply 2-4 mg 3 times a day. The maximum allowable single dose is not more than 10 mg, while the daily dose is 30 mg. The dose is determined depending on the indications, the route of administration and the age of the patient.

Platifillin in pancreatitis is prescribed subcutaneously 1-2 ml for 12 hours during a period of intense pain to reduce spasm of the smooth muscles of the gland.

Tablets Platifillin, instructions for use

Take orally 1 tablet 2 or 3 times a day.

Overdose

Paralytic ileus, urinary retention, accommodation paralysis, increased eye pressure, dryness of the mucous membrane of the mouth, nose and throat, which can cause difficulty in swallowing, mydriasis until the iris disappears completely, tremor, convulsions, hyperthermia, excitation of the central nervous system with subsequent suppression of it, as well as respiratory and vasomotor centers.

Treatment is forced diuresis, cholistenase inhibitors, such as Physostigmine, Galantamine, or Prozerin, which can relieve intestinal paresis and reduce tachycardia.

In cases of moderate arousal and convulsions of weak strength, it is best to administer magnesium sulfate, but in severe cases - sodium hydroxybutyrate, oxygen therapy and mechanical ventilation.

If tachycardia threatens the patient's life, then quinidine sulfate, propranolol are used.

Interaction

Indications for the use of Platifillin should take into account the presence of diseases that require the regular use of other medical supplies. When used simultaneously with the following substances, reactions may occur:

• Haloperidol - in patients with schizophrenia, the antipsychotic effect may be reduced.
• Prozerin - Platifillin is its antagonist.
• Phenobarbital, sodium etaminal, magnesium sulfate - an increase in the duration of hypnotic action.
• Other m-anticholinergics and drugs with m-anticholinergic activity (for example, Amantadine, Phenothiazine, tricyclic antidepressants, some antihistamines) - an increase in the likelihood of adverse reactions.
• Morphine - increased inhibitory effect of Platifillin on the cardiovascular vascular system.
• MAO inhibitors - positive chronotropic (increased heart rate) and bathmotropic effect (increased excitability of the heart).
• Cardiac glycosides - a positive bathmotropic effect.
• Analgesics, sedatives and anxiolytics can enhance the effect of Platifillin in case of pain, as a result of smooth muscle spasm.
• Antihypertensive / sedatives enhance the effect of Platyfillin in vascular spasms.

Terms of sale

Platifillin solution and Platifillin tablets with papaverine are available by prescription.

Storage conditions

In a place protected from light rays, preferably in tightly closed original packaging, at a temperature not exceeding 30 ° Celsius.

Best before date

Ampoules can be stored in unopened packaging for five years, tablets - three years.

special instructions

children

Children with brain damage are at risk (the drug can enhance the effects of the disease), in addition, it is not recommended to take the drug for children with Down syndrome (there is a possibility of unusual dilation of the pupils and increased heart rate), cerebral palsy (more pronounced reaction to anticholinergic influence). It is not recommended to give Platifillin injections to children under 15 years of age.

During pregnancy and lactation

Information on the safety of using Platifillin during pregnancy or lactation ( breastfeeding) on the this moment missing. It must be borne in mind that the expected benefit to the mother must significantly exceed the possible risks to the fetus or child.

Analogues

• Meteospasmil;
• Winboron;
• Infacol.

Reviews about Platifillin

The reviews confirm the effectiveness of the remedy, but the use requires great care, because Platifillin affects smooth muscles, the tension and relaxation of which a person cannot control - only feel the consequences of her atony or an increase in tone. Supervision is needed by a competent specialist who can correctly regulate intervention in this area without causing great harm to health.

Platifillin price, where to buy

The price of ampoules (for 10 pieces in a box) averages 50 rubles, the price of Platifillin tablets with papaverine is slightly higher - 140-180 rubles. (package contains 10 tablets).

Europharm* 4% discount with promo code medside11

Pharmacy IFK

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Papaverine

Composition and form of release of the drug

1 ml - ampoules (10) - packs of cardboard.
1 ml - ampoules (5) - blister packs (2) - cardboard packs.

pharmachologic effect

Blocker of m-cholinergic receptors. Compared with, it has a less pronounced effect on peripheral m-cholinergic receptors (in terms of its effect on smooth muscle cells of the digestive tract and the circular muscle of the iris, it is 5-10 times weaker than atropine). By blocking m-cholinergic receptors, it disrupts the transmission of nerve impulses from postganglionic cholinergic nerves to the effector organs and tissues innervated by them (heart, smooth muscle organs, external secretion glands); also inhibits n-cholinergic receptors (much weaker). The anticholinergic effect is more pronounced against the background of an increased tone of the parasympathetic part of the vegetative nervous system or the action of m-holinostimulators.

To a lesser extent than atropine, causes tachycardia, especially when used in high doses. By reducing the influence of n.vagus, it improves the conduction of the heart, increases the excitability of the myocardium, and increases the minute volume. It has a direct myotropic antispasmodic effect, causes the expansion of small vessels of the skin. In high doses, it depresses the vasomotor center and blocks the sympathetic ganglia, as a result of which the vessels dilate and blood pressure decreases (mainly with intravenous administration). Weaker than atropine inhibits the secretion of endocrine glands; causes a pronounced decrease in the tone of smooth muscles, the amplitude and frequency of peristaltic contractions of the stomach, duodenum, small and large intestine, a moderate decrease in the tone of the gallbladder (in persons with hyperkinesia of the biliary tract); with hypokinesia - the tone of the gallbladder rises to a normal state. Causes relaxation of the smooth muscles of the uterus, Bladder and urinary tract; having an antispasmodic effect, eliminates pain. Relaxes the smooth muscles of the bronchi, caused by an increase in the tone of n.vagus or cholinergic stimulants, increases the volume of breathing, inhibits the secretion of the bronchial glands; reduces the tone of the sphincters.

When instilled into conjunctival sac eye and parenteral administration causes pupil dilation due to relaxation of the circular muscle of the iris. At the same time, intraocular pressure rises and accommodation paralysis occurs (relaxation of the ciliary muscle of the ciliary body). In comparison with atropine, the effect on accommodation is less pronounced and shorter. It excites the brain and respiratory center, to a greater extent - the spinal cord (in high doses, convulsions, depression of the central nervous system, vasomotor and respiratory centers are possible). Penetrates through the BBB.

Pharmacokinetics

After oral administration, it is well absorbed from the gastrointestinal tract. It undergoes hydrolysis with the formation of platinecin and platinic acid.

Indications

Peptic ulcer of the stomach and duodenum, pylorospasm, cholecystitis, cholelithiasis, intestinal colic, renal colic, biliary colic; (to prevent broncho- and laryngospasm), bronchorrhea; algomenorrhea; spasm of the cerebral arteries; angiotrophoneurosis; arterial hypertension, angina pectoris (as part of combination therapy).

Pupil dilation for diagnostic purposes (including examination of the fundus, determination of the true refraction of the eye); acute inflammatory eye diseases (including iritis, iridocyclitis, keratitis), eye injuries.

Contraindications

Hypersensitivity to platifillin.

Dosage

Applied inside, parenterally (s / c, / in), rectally, topically in ophthalmology.

The dose depends on the indications, the route of administration, the age of the patient.

Side effects

From the side digestive system: dry mouth, thirst, intestinal atony.

From the side of the cardiovascular system: decrease in blood pressure, tachycardia.

From the side of the central nervous system and peripheral nervous system: CNS excitation, dizziness, dilated pupils, accommodation paralysis, headache, photophobia, convulsions, acute psychosis.

From the urinary system: difficulty urinating, urinary retention.

Others: lung atelectasis.

Adverse reactions are most likely when using platyfillin in high doses.

drug interaction

With simultaneous use with haloperidol in patients with schizophrenia, a decrease in the antipsychotic effect is possible.

Platifillin is an antagonist of prozerin.

With simultaneous use, the duration of the hypnotic effect of phenobarbital, sodium etaminal, increases.

With simultaneous use with other m-anticholinergics, as well as with drugs with m-anticholinergic activity (including amantadine, haloperidol, phenothiazine, MAO inhibitors, tricyclic antidepressants, some antihistamines), the risk of side effects increases.

Enhances the inhibitory effect of platyfillin on the cardiovascular system.

With simultaneous use with MAO inhibitors, a positive chrono- and bathmotropic effect is observed; with cardiac glycosides - a positive bathmotropic effect.

With pain associated with spasms of smooth muscles, the action of platyfillin is enhanced by sedatives and anxiolytics, with vascular spasms - antihypertensive and sedatives.

special instructions

Use with caution in patients with diseases of the cardiovascular system, in which an increase in heart rate may be undesirable: atrial fibrillation, tachycardia, chronic insufficiency, ischemic heart disease, mitral stenosis, arterial hypertension, acute bleeding; with thyrotoxicosis (possibly increased tachycardia); elevated temperature (may still rise due to suppression of the activity of the sweat glands); with reflux esophagitis, hiatal hernia, combined with reflux esophagitis (decrease in motility of the esophagus and stomach and relaxation of the lower esophageal sphincter can slow gastric emptying and increase gastroesophageal reflux through the sphincter with impaired function); in diseases of the gastrointestinal tract, accompanied by obstruction - esophageal achalasia, pyloric stenosis (possible decrease in motility and tone, leading to obstruction and retention of stomach contents), intestinal atony in elderly patients or debilitated patients (possible development of obstruction), paralytic ileus intestines; with an increase intraocular pressure- angle-closure (mydriatic effect, leading to an increase in intraocular pressure, may cause an acute attack) and open-angle glaucoma (mydriatic effect may cause some increase in intraocular pressure; therapy may need to be adjusted); with nonspecific ulcerative colitis (high doses can inhibit intestinal motility, increasing the likelihood of paralytic ileus, in addition, the manifestation or exacerbation of such a severe complication as toxic megacolon is possible); with dry mouth (long-term use may cause a further increase in the severity of xerostomia); with liver failure (decreased metabolism) and renal failure (risk of side effects due to reduced excretion); in chronic lung diseases, especially in young children and debilitated patients (a decrease in bronchial secretion can lead to thickening of secretions and the formation of plugs in the bronchi); with myasthenia gravis (the condition may worsen due to inhibition of the action of acetylcholine); prostatic hypertrophy without urinary tract obstruction, urinary retention or a predisposition to it, or diseases accompanied by urinary tract obstruction (including the bladder neck due to prostatic hypertrophy); with gestosis (possibly increased arterial hypertension); brain damage in children (CNS effects may be exacerbated); Down's disease (possibly unusual dilation of the pupils and increased heart rate), cerebral palsy (the reaction to anticholinergics may be most pronounced).

Influence on the ability to drive vehicles and control mechanisms

It is necessary to refrain from potentially hazardous activities that require heightened attention and speed of psychomotor reactions.

Pregnancy and lactation

Data on the safety of the use of platyfillin during pregnancy and lactation (breastfeeding) are not available.

Application in childhood

Use with caution in chronic lung diseases in young children (decrease in bronchial secretion can lead to thickening of the secret and the formation of plugs in the bronchi); brain damage in children (CNS effects may be exacerbated); Down's disease (possibly unusual dilation of the pupils and increased heart rate), cerebral palsy (the reaction to anticholinergics may be most pronounced).

For impaired renal function

Use with caution in renal insufficiency (risk of side effects due to reduced excretion).

For impaired liver function

Use with caution in hepatic impairment.

Content

With spasm of smooth muscle muscles and pain syndrome, doctors prescribe medicinal product Platyphyllin (Platyphyllin) with vasodilating (vasodilating), anticholinergic, sedative and antispasmodic action. Tablets or injections are used as part of complex therapy for diagnostic procedures. Self-medication is contraindicated, before starting the course, you need to consult a doctor.

Composition and form of release

The drug Platifillin is a representative of the pharmacological group of M-cholinergic receptor blockers. Specified the drug has 2 forms of release - tablets for oral administration and a solution for infusion. The therapeutic composition is poured into ampoules, 5 or 10 pcs. in every package. Additionally attached ampoule knife, instructions for use. Combined drug Platifillin with papaverine is produced in the form of white tablets, 10 pcs. in blisters. Features of the chemical composition:

The mechanism of action of Platifillin

The specified medication, being a pyrrolizidine alkaloid, provides a calming effect on the vasomotor center, moderately blocks the N-cholinergic receptors of the autonomic ganglia. Platifillina hydrotartrate inhibits the secretion of bronchial and salivary glands, eye accommodation, sweating. The specified component contributes to the expansion of the pupils, an increase in heart rate, a decrease in the activity of the digestive tract, biliary tract and gallbladder. Platifillin relieves spasms, suppresses an attack of pain.

The drug does not affect the activity of M-cholinergic receptors of the central nervous system (central nervous system). After parenteral (intravenous, intramuscular) administration, the active substances accumulate in the blood and are evenly distributed in the tissues. Platyfillin hydrotartrate is metabolized in the liver, inactive decay products are excreted by the kidneys with urine.

Indications for use

Doctors recommend the drug Platifillin for acute pancreatitis. The list of diseases that this medication treats does not end there. Instructions for use contains list of medical indications:

• peptic ulcer of the stomach and duodenum;
• cholecystitis (inflammation of the gallbladder);
• cholelithiasis (cholelithiasis);
• arterial hypertension;
• intestinal, hepatic, renal, biliary colic;
• pylorospasm;
• spasm of the arteries of the brain;
• algomenorrhea (painful menstruation);
• bronchorrhea (activity of the glands of the bronchial mucosa);
• angina pectoris, angiotrophoneurosis (composed of complex treatment);
• prevention of bronchospasm, laryngospasm in bronchial asthma;
• diagnostics in ophthalmology (to determine the true refraction of the eye, with corneal injuries).

Method of application and dosage

Instructions for use Platifillin describes the dosage and course of treatment for a particular disease. The drug is prescribed orally, parenterally (subcutaneously, intramuscularly), rectally, in ophthalmology - externally (for diagnostic procedures). Self-medication is contraindicated. The attending physician individually determines the daily dose.

Platifillin tablets

The drug Platifillin with papaverine is intended for oral administration.. According to the instructions, adults are prescribed 1 table, children over 10 years old - half a table, patients 6-10 years old - a quarter of a table. 2-3 times a day. A single dose is required to drink before meals. The tablets are supposed to be swallowed whole, with plenty of water.

Injections Platifillin

The drug is administered intravenously, intramuscularly with a syringe. Platifillin in ampoules is an emergency aid for the relief of acute pain syndrome.According to the instructions, the medication is prescribed at 2-4 mg (1-2 ml) for a course longer than 10 days. Maximum daily dose is 15 ml (30 mg), single - 5 ml (10 mg). Dosages are adjusted depending on the age of the patient, the diagnosis.

special instructions

The medicine Platifillin disrupts the functioning of the nervous system, reduces the psychomotor functions of the body. During treatment, it is required to refrain from driving vehicle, do not engage in work that requires increased concentration of attention. Instructions for use contains instructions for patients:

1. In case of nervous disorders, urinary retention, rhythm disturbance and myocardial contraction frequency, increased intraocular pressure, treatment is carried out with caution.
2. When using other medications, it is important to inform the attending physician who plans to prescribe a course of the indicated blocker of M-cholinergic receptors.
3. It is forbidden to exceed the maximum daily dosage, otherwise the patient's well-being deteriorates sharply.

Platifillin during pregnancy

When carrying a fetus, the use of medication is strictly contraindicated. Clinical researches confirmed that the treatment of a pregnant woman increases the risk of developing arterial hypertension. The use of the drug during breastfeeding is also prohibited, since the active substances in high concentrations are excreted from mother's milk. If necessary, it is recommended to temporarily transfer the child to adapted mixtures.

In childhood

With Down's syndrome and cerebral palsy, such a pharmaceutical prescription in childhood is contraindicated. Restrictions on the use apply to chronic diseases of the lungs, cardiovascular system. According to the instructions for use, the recommended doses for both forms of release:

Release form	Patient's age, years	Single dose, tab., (mk / kg for solution)	The maximum dose, tab., (mk / kg for solution)	Number of daily doses
tablets				2-3 times a day, depending on the disease, recommendations of the attending physician
solution in ampoules

drug interaction

More often, Platifillin is prescribed as part of complex therapy. In this case, it is important to study the information on drug interactions described in the instructions for use:

1. When combined with Haloperidol in patients with schizophrenia, the antipsychotic effect is reduced.
2. In combination with Morphine, the functions of the cardiovascular system are inhibited, the symptoms of bradycardia disappear.
3. Magnesium sulfate, sodium etaminal, Phenobarbital enhance the hypnotic effect of platyfillin hydrotartrate.
4. In combination with phenothiazine, amantadine, inhibitors, tricyclic antidepressants, some antihistamines increased risk of side effects.
5. When combined with analgesics, anxiolytics, sedatives, the analgesic effect of Platifillin is enhanced.
6. Cardiac glycosides provide a positive bathmotropic effect (increased myocardial activity).
7. With simultaneous use with MAO inhibitors, the heart rate increases, a chronotropic and bathmotropic effect is observed.
8. With severe vasospasm, the drug enhances the therapeutic effect of sedative and antihypertensive drugs.
9. Platifillin is an antagonist of Prozerin.
10. Procainamide and Quinidine enhance the anticholinergic effect of the main drug.

Side effects

The drug is well tolerated by the body. In some clinical cases doctors do not exclude the occurrence of side effects. Among those:

• digestive system: intestinal atony, dry mouth, signs of dyspepsia, feeling of thirst;
• cardiovascular system: tachycardia (rapid heartbeat), arterial hypotension, tremor of the extremities;
• nervous system: dizziness, dilated pupils, eye accommodation paralysis, convulsions, photophobia, migraine attacks, acute psychosis, irritability;
• urinary system: delay and violation of urination;
• respiratory system: atelectasis of the lung (gluing of the alveoli of the lung);
• allergic reactions: urticaria, skin itching and swelling, hyperemia of the epidermis.

Overdose

When the daily doses of the median are exceeded, the side effects. The patient is worried about headache, paresis of accommodation and intestines, shortness of breath, hyperthermia and redness skin. According to the instructions for use, to eliminate the symptoms of an overdose, forced diuresis, the use of enzyme inhibitors - cholinesterase (Physostigmine, Galantamine, Prozerin) are recommended. These medicines weaken the paresis of the intestine and reduce tachycardia. In severe clinical cases, sodium oxybutyrate, oxygen therapy, artificial lung ventilation are prescribed.

Contraindications

According to the instructions for use, Platifillin is not recommended for all patients. Available medical contraindications:

• angle-closure glaucoma;
• renal, hepatic insufficiency of a severe form;
• myasthenia gravis;
• atherosclerosis in a pronounced form;
• stomach bleeding;
• tachycardia, arrhythmia;
• ulcerative colitis;
• intestinal atony;
• paralytic obstruction;
• coronary artery disease;
• thyrotoxicosis;
• body's hypersensitivity to active ingredients medication;
• pregnancy, lactation.

Terms of sale and storage

The drug is a prescription drug, sold in city pharmacies. Store it in a dry, dark place, limit exposure to sunlight. The shelf life of papaverine tablets is 3 years, the injection solution is 5 years. The medicinal composition must not be frozen. Expired medication must be disposed of.

Analogues

If Platifillin does not help or worsens the patient's well-being, the medication must be replaced. Reliable analogues and a brief description:

1. Meteospasmil. This is a medicine from the group of myotropic antispasmodics in the form of capsules. According to the instructions, the drug is prescribed for spastic stomach pains, during preparation for an x-ray. The recommended dose is 1 capsule 3 times a day with meals.
2. Winboron. Synthetic drug with a pronounced antispasmodic effect for oral administration. According to the instructions, the patient is prescribed 20–40 mg 3–4 times a day, regardless of food intake, but not more than 160 mg per day.
3. Infacol. A drug often used in pediatrics to suppress intestinal colic and spasms of smooth muscles. According to the instructions, the patient is prescribed 0.5 ml twice a day. Well drug therapy determined individually.

Platifillin price

The cost of the drug varies within 100 rubles for a package of 10 ampoules. The price depends on the number of ampoules (tablets) in the package, the reputation of the chosen pharmacy.

Instructions for use:

Platifillin is a pharmacological drug from the group of m-anticholinergics, which has an antispasmodic and weak sedative effect.

Composition and form of release

According to the instructions, Platifillin is available in ampoules as a solution for parenteral administration. In 1 ampoule 1 ml of 0.2% of the drug (2 mg of platifillin and water for injection).

Externally, Platifillin is a colorless clear liquid without smell.

This drug is produced in 10 ampoules in a cardboard box, instructions for use, an ampoule knife or a scarifier are also attached. If the package contains ampoules with dots or rings for opening, then the ampoule knife is not inserted.

Pharmacological action of Platyfillin

According to the instructions, Platifillin is a blocker of m-cholinergic receptors and has an antispasmodic effect on the smooth muscles of the digestive tract and bronchi, and also has a weak sedative (sedative) effect. This drug reduces the secretion of bronchial, salivary, lacrimal and sweat glands. In addition, Platifillin is able to dilate the pupil and cause moderate accommodation paralysis. This drug may increase intraocular pressure.

Indications for use

Indications for Platifillin are the following conditions:

• spastic pains of the digestive system (hepatic colic, intestinal dyskinesia, biliary dyskinesia);
• complex treatment of peptic ulcer of the stomach and duodenum;
• renal colic;
• bronchospasm in patients with diseases respiratory system(as an auxiliary component of treatment).

Contraindications to the use of Platifillin

This drug has fairly wide contraindications, so its use without a doctor's prescription is unacceptable. Platifillin is contraindicated for use in the following conditions:

• hypersensitivity to platifillin;
• angle-closure glaucoma;
• severe atherosclerosis, chronic heart failure II-III degree;
• heart rhythm disturbances, tachycardia;
• benign prostatic hyperplasia;
• signs of renal/liver failure;
• diaphragmatic hernia with reflux esophagitis;
• intestinal atony;
• gastrointestinal bleeding;
• ulcerative colitis;
• old and old age.

Indications for Platifillin should be carefully weighed during pregnancy and lactation, with coronary heart disease, mitral stenosis, arterial hypertension, thyrotoxicosis, diseases of the digestive system with obstruction phenomena (stenosis of the pyloric part of the stomach, achalasia of the esophagus, etc.), elevated body temperature, older age 40 years (there is a risk of undiagnosed glaucoma). Also, this drug should be used with caution in patients with ulcerative colitis, myasthenia gravis, urinary retention in history, chronic diseases lungs, Down's disease, cerebral palsy, and in patients of early childhood.

Dosage and administration

According to the instructions, Patifillin can be administered subcutaneously, intramuscularly.

For cupping acute pain in the abdomen caused by hepatic or renal colic, as well as peptic ulcer, it is recommended to administer the drug subcutaneously at a dose of 1-2 ml (2-4 mg) 2-3 times a day. The course of treatment can be up to 10 days. The maximum daily dose for an adult is 30 mg (15 ml of the drug), a single dose should not exceed 10 mg (5 ml).

For children, Platifillin is used in the following dosages:

• up to 1 year - a single dose of 0.035 mg / kg, the maximum daily dose - 0.07 mg / kg;
• 1-5 years - a single dose of 0.03 mg / kg, the maximum daily dose of 0.06 mg / kg;
• 6-10 years - a single dose of 0.025 mg / kg, the maximum daily dose of 0.05 mg / kg;
• 11-14 years - 0.02 mg / kg, the maximum daily dose for this age is 0.04 mg / kg.

Side effects of Platyfillin

According to the instructions, Platifillin can cause such side reactions as: dry mouth, decreased blood pressure, tachycardia (increased heart rate), dizziness, headache, convulsions, urinary retention, pulmonary atelectasis. According to reviews, Platifillin rarely causes side effects in young patients, mainly adverse reactions can occur in elderly patients with severe somatic pathology.

Overdose

With an overdose of Platifillin, paralytic ileus may develop, acute urinary retention (in patients with prostatic hyperplasia), accommodation paralysis, increased intraocular pressure, dryness of the mucous membranes of the mouth, swallowing disorders, mydriasis (pupil dilation until the disappearance of the iris), tremor, convulsions , fever, excitation / depression of the nervous system, dysfunction of the respiratory center, suppression of the activity of the vasomotor center.

Overdose treatment is reduced to the use of forced diuresis, the introduction of cholinergic stimulants and anticholinesterase drugs. With an increase in body temperature, antipyretic drugs, wet rubdowns are recommended. When excited, the patient is shown the introduction of an intravenous solution of sodium thiopental. With mydriasis should be instilled eye drops physostigmine, pilocarpine, phosphakol.

Interaction of Platifillin with other drugs

It is known that the use of Platifillin with phenobarbital, magnesium sulfate and chloride etaminal enhances their hypnotic and sedative effects.

Simultaneous use with other m-anticholinergics, haloperidol, phenothiazine, MAO inhibitors, tricyclic antidepressants and some antihistamines increases the risk of adverse reactions.

Anticholinesterase drugs are Platyfillin antagonists.

It is known that morphine in combination with this drug enhances the inhibitory effect on the cardiovascular system.

Analgesics, sedatives together with Platifillin increase its antispasmodic effect.

With vascular spasms, it is good to use Platifillin in combination with antihypertensive and sedative drugs.

special instructions

During treatment with Platifillin, according to reviews, it is necessary to refrain from driving vehicles and other work that requires increased attention.