tetracycline acid. What do Tetracycline tablets help with?

Family doctor, nutritionist. Head of the branch in the medical network "Healthy Generation".

Tetracycline tablets are a powerful drug that acts on the bacterial flora and quickly fights signs of infection caused by harmful microbes. Antibiotic, which is prescribed for intestinal infections, inflammation of soft tissues, complicated pathologies of ENT organs.

When treating with tetracycline, it is important to strictly follow the instructions for use. With an independent increase in the dose or duration of therapy, negative consequences occur in the form of liver damage, since it is this gland that is involved in the removal of the spent drug from the body. With a decrease in the dose and duration of treatment, the drug loses its effectiveness, and bacteria continue to multiply in tissues and organs.

Tetracycline is a broad-spectrum antibiotic drug. It is effective against various microorganisms, which include:

• streptococci;
• clostridia;
• staphylococci;
• salmonella;
• enterobacteria;
• coli.

The drug inhibits the formation of new bacterial colonies by blocking protein synthesis in their cells. The effect is achieved due to the active compound - tetracycline hydrochloride (tetracycline hydrochloridum), which is contained in an amount of 0.1 g.

The list of auxiliary compounds includes:

• talc;
• starch;
• sucrose;
• calcium stearate;
• gelatin;
• magnesium carbonate.

These are round, slightly convex coated tablets. They are packed in cardboard packs of 20 pieces.

List of absolute contraindications:

• pregnancy (all term);
• lactation;
• childhood;
• severe liver damage;
• leukopenia;
• mycoses;
• hypersensitivity to components.

In the absence of direct contraindications, the remedy can be used, but a doctor's consultation is required.

Antibiotic tablets are taken orally. The drug is swallowed without chewing, and washed down with a small amount of water. It is not recommended to replace the liquid with other drinks - tea, juices, milk. This will affect the rate of absorption of the drug.

To maintain the optimal concentration of the drug, it is necessary to observe the interval between taking the tablets. So, for adult patients, it is 6-8 hours.

The dosage for an adult varies depending on the nature of the disease and ranges from 200 to 500 mg.

Maximum safe daily dose medicines - 4 g.

The antibiotic is included in the treatment regimens for children older than 8 years. The child takes with an interval of 6 hours in an individual dosage. The amount of tetracycline hydrochloride recommended by pediatricians for children is determined based on body weight. The calculation is based on the formula 12-25 mg per kilogram of weight:

• with acute intestinal infections, infectious pathologies of the gastrointestinal tract - 12-20 mg per kg every 6 hours;
• with inflammation of the urinary organs - 20-25 mg per kg 4 times a day.

So, with acute cystitis, a child who weighs 30 kg should receive 750 mg of medication per day. This volume is divided into 3 doses (250 mg - 2.5 tablets) with an interval of 6 hours.

The antibiotic is effective in digestive disorders of a bacterial nature. Such diseases can be provoked by:

• salmonella;
• intestinal stick;
• pathogenic microorganisms.

For diagnosis, contact a medical institution. Tetracycline tablets are prescribed if the bacterial nature of the disease is established.

Dosage standard:

• 250 mg for mild diarrhea without other accompanying symptoms;
• 500 mg with frequent diarrhea (more than 4 times a day) against the background of fever, nausea, pain in the abdomen.

In the first three days, Tetracycline tablets are taken every 6 hours to stop the reproduction of pathogenic bacteria, then the drug is taken at intervals of 12 hours for another 3-4 days.

The dose of the drug for children depends on their weight. The agent is given at the rate of 12-20 mg per kilogram of mass. The resulting amount is divided into three doses. The drug is allowed after 8 years.

When treating diarrhea with tetracycline, keep in mind that the antibiotic only affects the bacterial flora. If an unpleasant symptom is provoked by a virus, then you will need to choose a different treatment regimen.

A cold is commonly understood as SARS. The disease proceeds in an acute form and is accompanied by a number of symptoms:

• temperature rise;
• pain in muscle tissues;
• general weakness;
• redness and sore throat;
• runny nose and swelling of the nasopharynx.

However, the use of antibiotics, including tetracycline tablets, will be erroneous. These symptoms develop due to the activity of viruses that are resistant to antimicrobial drugs. Colds require powerful antiviral agents and preparations for strengthening immune system:

• . Tablets are suitable for adults and children from three years. The child is given 1 tablet three times a day. Adults take 2 tablets 3 times a day. The total duration of treatment is 4 days.
• . Adult patients are taken according to the following scheme. On the first day, drink 5 tablets with an interval of 30 minutes (2 hours). Then take 3 more tablets with an interval of 3 hours. All subsequent days drink one tablet three times a day. The total duration is a week. From 1 month to 18 years of age, it is recommended to take children's Anaferon. These are lozenges. On the first day, a total of 8 tablets are drunk (the first 5 with an interval of 30 minutes, another 3 tablets - 3 hours). From 2 to 7 days of treatment - 1 tablet 3 times a day. Infants pre-dissolve the drug in water.
• Ingavirin. Adult patients take one capsule per day (90 mg dosage), children over 7 years old - 1 capsule per day (60 mg dosage). The total duration of therapy is 5-7 days.

The Russian company BIOSINTEZ produces a combined product with two active substances. The tablets are based on the antibiotic tetracycline hydrochloride and nystatin, which is a powerful antifungal compound. The drug successfully fights not only bacteria, but also Candida yeast-like fungi.

This composition allows you to prescribe a remedy for:

• candidiasis (thrush);
• bronchitis;
• inflammation of the lungs;
• whooping cough;
• pyelonephritis;
• syphilis;
• gonorrhea;
• prostatitis;
• furunculosis;
• infected eczema.

Tetracycline with nystatin is prohibited for children and adolescents under 18 years of age.

Adults take 250 mg 4 times in 24 hours. The course of treatment is 7-10 days.

The standard release form is 100 mg tablets (0.1 g). The medication is taken orally, regardless of food, in the following dosages:

• for adults, 0.3-0.5 g every 4 hours (alternative regimen - 0.5-1 g twice a day);
• for children after 8 years - 6-12 mg / kg 4 times a day (the dose can be doubled and the interval between doses of 12 hours should be observed).

Children under 8 years of age should not be given the drug.

The duration of the course for children and adults is 7-10 days.

Prescribe medication for:

• bronchitis;
• pneumonia;
• otitis;
• acne;
• intestinal disorders.

The antibiotic is produced in the format of 100 mg tablets, 20 units per pack. If the patient is prescribed a dose of 500 mg, then the same remedy is purchased, but its amount is increased.

A dosage of 500 mg is required for adult patients with severe microbial infections:

• lower respiratory tract(bronchitis, pneumonia);
• genitourinary system (cystitis, pyelonephritis);
• digestive tract (salmonellosis, typhoid fever).

The patient will receive 1.5-2 g of tetracycline hydrochloride per day. It is impossible to independently increase the dose to 500 mg in order to quickly stop the symptoms of the disease. Ignoring this rule will lead to the development of side effects - headache, constipation, allergic rashes.

Tetracycline LekT is an antibiotic in the form of film-coated tablets, packaged in 20, 30 or 40 pieces.

The list of indications for the use of antibiotics includes:

• conjunctivitis;
• blepharitis;
• osteomyelitis;
• brucellosis;
• gonorrhea;
• syphilis;
• cholecystitis;
• pneumonia.

The basis of the drug is tetracycline, which inhibits protein synthesis in bacterial cells. Take the drug inside according to the scheme:

• children over 8 years old - 25-50 mg per 1 kilogram of body weight every 6 hours;
• adults - 250-500 mg with an interval of 6 hours.

The duration of the course is 7-10 days.

For children under 8 years old, other medicines are selected, since Tetracycline LekT has an age limit:

• . The tablets are suitable for children from 12 years of age. Take 1 tablet every 12 hours. A child under 12 years of age is prescribed a suspension. Dose for children up to a year - 0.5 teaspoon three times a day, from a year to 7 years - 1 tsp. three times a day, after 7 years - 2 tsp. three times per day. The duration of treatment is 5-7 days.
• Sumamed. From 6 months, a suspension is given (10 mg, or 0.5 ml, of drugs per kg once a day). From 3 to 12 years - 125 mg tablets, from 12 years - 500 mg tablets (once a day). The duration of the course is 5-7 days.
• Suprax. Up to 12 years old, 8 mg / kg of body weight is prescribed once a day, after 12 years - 400 mg once a day. duration of treatment - 1 week.

Doctors prescribe analogues if:

• there are contraindications to the use of tetracycline;
• diagnosed hypersensitivity to the components;
• analyzes show the resistance of a particular strain of microorganisms.

Ciprofloxacin

The drug is taken orally twice a day, 250 or 500 mg, depending on the severity of the symptoms. In some cases, the dose is increased to 750 mg (for acute infections urinary tract). The duration of the course varies from 5 to 15 days.

Contraindications include:

• pregnancy;
• breast-feeding;
• sensitivity to components;
• age less than 18 years;
• deficiency of glucose-6-phosphate dehydrogenase.

The cost of the drug starts from 20 rubles for a package of 10 tablets of 250 mg. The price of the drug 500 mg - from 80 rubles.

Amoxicillin

Antibiotic with the same substance in the composition. It belongs to the group of penicillins and is effective for:

• peritonitis;
• cystitis;
• stomach ulcer;
• sinusitis;
• otitis;
• salmonellosis;
• typhoid.

Tablets are drunk three times a day for 500 mg. For children, the dose is halved. The duration of therapy is 5-12 days.

It acts carefully, therefore it has a minimal list of contraindications. The drug is prohibited for individual intolerance. It can be taken during pregnancy and in childhood from 5 years under the supervision of a specialist.

This inexpensive drug. It can be found in pharmacies for 40-100 rubles.

Flemoxin Solutab

It's a drug latest generation. It contains amoxicillin. The tablets are dispersible, that is, they must be dissolved in water before use. This increases the availability of the active substance and allows it to quickly enter the bloodstream and start fighting infection.

Flemoxin Solutab is taken for bacterial diseases of soft tissues, ENT organs, gastrointestinal tract, excretory and reproductive systems.

The dose of the drug depends on the age of the patient:

• babies up to a year - 30-60 mg per kg of body weight per day;
• from 1 to 3 years - 250 mg;
• from 3 to 10 years - 375 mg;
• after 10 years - 500-750 mg;
• adults - 500-750 mg.

Infants up to a year receive the remedy three times a day. Everyone else divides the indicated dosage into two doses per day.

Flemoxin Solutab is a modern and safe analogue of Tetracycline. It can not be taken only with intolerance to the components. Among the shortcomings can be noted the high cost - from 250 to 500 rubles.

Tetracycline is a broad-spectrum antibiotic with a bacteriostatic effect.

The drug destroys gram-positive and gram-negative bacteria. Tetracycline has been widely used as a drug for the treatment of various purulent diseases skin (including furunculosis, acne), inflammatory processes of the respiratory tract (tonsillitis, bronchitis, pneumonia, etc.) and the genitourinary system (gonorrhea, syphilis, etc.).

It has various dosage forms: tablets for oral administration, ointment for external use. It is used for the treatment of infectious diseases, the causative agents of which are pathogenic bacteria sensitive to the action of the drug.

Clinical and pharmacological group

Broad spectrum antibiotic.

Terms of sale from pharmacies

Can buy by prescription.

Price

How much does Tetracycline cost in pharmacies? The average price is at the level of 100 rubles.

Composition and form of release

Tetracycline tablets are pink, round and biconvex. The main active ingredient of the drug is tetracycline, its content in one tablet is 100 mg. It also includes additional components, which include:

• calcium stearate.
• Macrogol.
• Titanium dioxide.
• polyvinyl alcohol.
• Microcrystalline cellulose.
• Talc.
• Croscarmellose sodium.

Tablets are packaged in a blister of 20 pieces. A cardboard pack contains 1 blister with tablets, as well as instructions for using the drug.

pharmachologic effect

According to the classification, this drug is included in the antibiotics of the tetracycline group. It is active against many gram-positive microbes: Clostridium spp., Staphylococcus spp., Listeria spp., Streptococcus pneumoniae, Bacillus anthracis, Actinomyces israelii. In addition, this agent can be used against many gram-negative microorganisms: Haemophilus ducreyi, Salmonella spp., Acinetobacter spp., Yersinia pestis, Haemophilus influenzae, Bartonella bacilliformis, Borrelia burgdorferi, Enterobacter spp., Bordetella pertussis, Klebsiella spp., Vibrio fetus, Shigella spp., Francisella tularensis, Vibrio cholerae, Rickettsia spp., Escherichia coli, Brucella spp.

The drug is also active against Chlamydia psittaci, Treponema spp., Calymmatobacterium granulomatis, Chlamydia trachomatis, Mycoplasma pneumoniae.

The degree of absorption of the drug when taken on an empty stomach is 75-77%, in case of use during meals, absorption decreases. The active substance binds to plasma proteins by 55-65%. At oral administration the maximum concentration in plasma is observed after 2-3 hours. It gradually decreases over 8 hours.

Once in the body, the active substance accumulates in the liver, lungs, kidneys, as well as in organs that are distinguished by a developed reticuloendothelial system. The content in bile is approximately 5-10 times greater than in blood serum. Tetracycline hydrochloride also accumulates in bone tissue, dentin, tumor tissues, enamel of milk teeth. Penetrates through the placental barrier and into milk during lactation.

The half-life is 6-11 hours. 20-50% of the drug is excreted through the intestines.

Indications for use

The official instructions for the use of Tetracycline tablets indicate that they are effective in the following pathologies:

1. Everything infectious diseases caused by drug-susceptible pathogens.
2. Intestinal amoebiasis, cholera, anthrax, brucellosis, rickettsiosis, syphilis, tularemia, trachoma, yaws, listeriosis, uncomplicated gonorrhea, plague, inguinal granuloma, chlamydia, psittacosis, actinomycosis, etc.
3. Infections of the skin, bones, soft tissues, mucous membranes (gingivitis, stomatitis, including ulcerative necrotic), acne, carbunculosis, furunculosis, suppuration skin, conjunctivitis.
4. Bacterial infections of the respiratory, urinary tract.

Contraindications

Coated tablets:

• leukopenia;
• children's age up to 8 years;
• second and third trimesters of pregnancy;
• breastfeeding period;
• increased individual sensitivity to the components of the drug.

Tetracycline tablets should be used with caution in patients with renal insufficiency.

Dosage and method of application

As indicated in the instructions for use, Tetracycline tablets are taken orally with plenty of liquid.

Adults are usually prescribed 4 times a day for 0.25-0.5 g or 2 times a day (every 12 hours) for 0.5-1 g. The maximum dose is 4 g per day. Children from 8 years of age are prescribed 4 times a day (every 6 hours) at 6.25-12.5 mg / kg or every 12 hours at 12.5-25 mg / kg.

1. In uncomplicated gonorrhea, the drug is prescribed in an initial single dose of 1.5 g, after which for 4 days every 6 hours, 0.5 g (total dose - 9 g).
2. In the treatment of acne, Tetracycline is used at a dose of 0.5-2 g per day. When the condition improves (usually after 3 weeks), the dose is gradually reduced to a maintenance dose of 0.125-1 g. Adequate remission of acne can be achieved with intermittent therapy or taking the drug every other day.
3. With early syphilis for 15 days, 0.5 g of Tetracycline should be taken every 6 hours, with late syphilis the drug is taken within 30 days.
4. In the treatment of brucellosis for 3 weeks, every 6 hours, 0.5 g of tetracycline is indicated simultaneously with intramuscular injection 1 g streptomycin (during the first week - every 12 hours, during the second week - 1 time per day).
5. For uncomplicated urethral, ​​rectal and endocervical infections caused by Chlamydia trachomatis, the drug at a dose of 0.5 g should be taken 4 times a day for at least 7 days.

Side effects

Possible adverse reactions:

• CNS: headache, increased HF pressure, dizziness;
• urinary system: azotemia, hypercreatininemia;
• hematopoietic organs: hemolytic anemia, neutropenia, thrombocytopenia, eosinophilia;
• organs of the digestive system: dysphagia, increased sensitivity of the papillae of the tongue, dulling of hunger, diarrhea, glossitis, gastritis, hepatotoxic effect, pancreatitis, enterocolitis, vomiting, nausea, esophagitis, stomach ulcers and duodenum, increased activity of liver transaminases, dysbacteriosis;
• allergies and immunopathological reactions: skin flushing, angioedema, maculopapular rash, systemic lupus erythematosus, anaphylactoid reactions, photosensitivity;
• others: superinfection, hypovitaminosis B, discoloration of the enamel of milk teeth, candidiasis, stomatitis.

Overdose

Exceeding the recommended therapeutic dosage of tetracycline tablets is accompanied by nausea, vomiting, blood in the urine (hematuria). In this case, after preliminary washing of the stomach, intestines, as well as the intake of intestinal sorbents ( Activated carbon) held symptomatic therapy in a medical hospital, since there is no specific antidote for tetracycline.

special instructions

Before you start using the drug, read the special instructions:

1. The use of tetracycline in children during the development of teeth can lead to irreversible discoloration of their teeth.
2. During the period of treatment for the prevention of hypovitaminosis, vitamins of groups B, K, brewer's yeast should be used.
3. With prolonged use, it is necessary to periodically monitor the functions of the kidneys, liver, and hematopoietic organs.
4. Tetracycline should not be taken simultaneously with milk and other dairy products, because. at the same time absorption of an antibiotic is broken.

Interaction with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

1. With the simultaneous use of tetracycline with retinol, intracranial hypertension may develop.
2. With simultaneous use with cholestyramine or colestipol, there is a violation of the absorption of tetracycline.
3. Preparations containing metal ions (antacids, preparations containing iron, magnesium, calcium) form inactive chelates with tetracycline, and therefore their simultaneous administration should be avoided.
4. It is necessary to avoid combination with penicillins, cephalosporins, which have a bactericidal effect and are antagonists of bacteriostatic antibiotics (including tetracycline).

The composition of Tetracycline, in addition to auxiliary chemicals, such as starch, includes an active, active substance - tetracycline. Chemical formula tetracycline is as follows: C 22 H 24 N 2 O 8.

Tetracycline prescription for Latin looks like this: Tetracyclini 0.25.

An antibiotic such as Tetracycline is in the RLS (Registry medicines) RF, so it can be easily and inexpensively bought at any pharmacy.

OKDP and Tetracycline

OKDP - all-Russian classifier of types of economic activity. Within its framework, Tetracycline was assigned the following classifier code: OK 004-93. But this code became invalid on January 1, 2017. Now Tetracycline code OKPD 2 OK 034-2014 (CPE 2008)

In what form is it issued

It is a very strong antibiotic, available in the form of Tetracycline 100 mg tablets, ointments, creams, suspensions, syrups, powders for self-manufacturing(or by the medical staff) the liquid form of this medicine for syrups and injections.

Tetracycline: for what ailments is indicated and effective

According to the instructions for use, Tetracycline will quickly relieve the following (severe) diseases:

• Tularemia (disease transmitted from animals);
• Brucellosis;
• Diseases of the urinary tract;
• Psittacosis (an infection transmitted from birds to humans);
• Inflammation of the meninges;
• Mastitis;
• eye infections;
• Phlegmon;
• Cholera;
• Juvenile acne.

When asked what else Tetracycline helps with, we can say with confidence that this drug is very effective in the treatment of sepsis (in tandem with different types antibiotics).

Also, this medicine helps to cure diseases such as:

1. Pneumonia;
2. Pleurisy;
3. Endocarditis;
4. Whooping cough;
5. Dysentery;
6. Gonorrhea.

Without antibiotic treatment, such diseases end in disability or even death.

In accordance with the indications for use, Tetracycline is used in preventive purposes. To avoid the occurrence of complications in those who have undergone surgery. Successfully use tetracycline and prostatitis.

Tetracycline: dosage

How to take tetracycline, the doctor will say, for the treatment of the most common diseases, the dosage of tetracycline is indicated in the annotation to the drug.

Before taking this antibiotic, it is necessary to determine the sensitivity of the microflora to it that provoked the disease in the patient.

Adults can take tetracycline hydrochloride according to the instructions for use at 0.25 mg every six hours, if the disease is severe, neglected - two grams per day. Children over the age of seven years can drink this drug at twenty-five milligrams per kilogram of the child's body every 6 hours.

This drug in the form of a suspension (or syrup) is drunk by children at 30 mg per kilogram of the child's body per day in four divided doses every six hours, based on the fact that 1 drop of the suspension contains six milligrams of tetracycline.

Adults can also drink syrup - 17 ml for 24 hours, the intake must be divided into 4 times. To prepare such a syrup, you need to use 1-2 granules. Children can drink tetracycline syrup prepared according to the annotation: at the rate of 30 mg of granules per 1 kg of body weight. It should be drunk four times a day, based on the fact that one milliliter is equal to 30 milligrams of tetracycline.

To prepare such a syrup, forty milliliters of water or four measuring spoons (included in the package) should be poured into the bottle, then shaken. In severe forms of infectious diseases (STDs, pneumonia, etc.), adults can use Tetracycline 500 mg as many times as directed by the attending physician.

Tetracycline side effects

The tetracycline group of antibiotics is well tolerated by both adults and children, but in some cases the following side effects are possible:

• Nausea;
• urge to vomit;
• Diarrhea;
• Decreased appetite;
• Plaque on the tongue;
• Hives;
• Quincke's edema;
• High sensitivity of the skin to the influence of solar radiation;
• Dark yellow tooth enamel (in infants who took tetracycline during the period of tooth formation);
• Candidiasis (with prolonged use of this antibiotic);
• Increased blood pressure;
• Dizziness;
• Neutropenia;
• Thrombocytopenia;
• Hemolytic anemia;
• Hypercreatininemia;
• Azotemia;
• Septicemia.

The last side effect can be avoided by taking Tetracycline and Nystatin (an antifungal). If the side effect of tetracycline threatens the life of the patient, the antibiotic is changed by prescribing another one - not from the tetracycline group.

Tetracyclines: a list of drugs in this group

1. Aerosols: Vidoccin and Vibramycin;
2. Capsules: Doxal;
3. Tablets: Doxilan, Doxycycline Nycomed, Doxycycline Shtada, Tetracycline hydrochloride, Unidox Solutab, Monoclin, Xedocin;
4. Solution for injection (tetracycline in injections): Dixycycline;
5. Eye ointment: Tetracycline-AKOS.

Tetracyclines: classification

There are the following drugs of the tetracycline group:

• Chrotetracycline (natural medicines isolated from mushroom cultures);
• Tetracycline is a semi-synthetic analogue of chlortetracycline;
• metacycline and doxycycline (preparations with marching oxytetracycline);
• Olemorphocycline and oletethrin ( combined preparations with oleandomycin);
• minocycline;
• Tigecycline - glycylcyclines.

When not to take tetracycline

There are a number of patient conditions in which tetracycline should not be treated:

1. Allergy to tetracycline and related antibiotics (doxycycline and oxytetracycline);
2. Fungal diseases (unless treated with a drug such as tetracycline + nystatin, yes there is such a thing);
3. kidney disease;
4. Leukopenia (decrease in the level of white blood cells in the blood);
5. Pregnancy;
6. Children under the age of 8;
7. Breastfeeding period.

Tetracycline: analogues

• Bioparox (fusafungin);
• Hyoxysin;
• Dexatobrom;
• Dioxidine;
• Nalidixic acid;
• Nitroxoline;
• Nifuroxacid;
• Ofloksin;
• Tavanic;
• medomycin;
• Metacycline;
• Terzhinan;
• Tetracycline Hydrochloride;
• Furadonin;
• Chloramphenicol;
• Ciprofloxacin;
• Unidox.

How Tetracyclines Work

Within the framework of the mechanism of action of tetracyclines, the antibacterial effect of tetracyclines on protein biosynthesis of a microbial cell at the level of ribosomes occurs.

For tetracycline, the price is acceptable in any pharmacy. The cost of tetracycline depends on the form of release of this drug. So, tetracycline hydrochloride 100 mg in one tablet in tablets costs about 80 rubles a package of 20 tablets, and Unidox (tablets, more precisely, Tetracycline powder used for solution) costs 340 rubles.

For Tetracycline with Nystatin, the price will be approximately 120 rubles per package of 10 tablets (how to take Tetracycline with Nystatin, the instructions for use for this drug will tell you). Tetracycline ointment (3%) will cost about 50 rubles, it all depends on the country of manufacture.

Tetracycline and other medicines

When using Tetracycline in symbiosis with bactericidal antibiotics, the effectiveness of the latter is reduced. These are cephalosporins and penicillins. Antacids in tandem with tetracycline reduce absorption.

Tetracycline, taken at the same time as estrogen-containing oral contraceptives, reduces the effectiveness of the latter, increasing the risk of bleeding.

If you drink the antibiotic we are describing along with Retinol, this can increase intracranial pressure.

Tetracycline and alcohol

Since tetracycline is an antibiotic, the simultaneous use of tetracycline and alcohol is strictly prohibited.

Tetracycline and other antibiotics in the treatment of bacterial infections

Many people ask: "Erythromycin or Tetracycline, which is better?" Note that if we are talking about ointments, then, for example, in the treatment of conjunctivitis, it will be more effective to use an ointment based on tetracycline.

If you are looking for an answer to the question: Levomycetin or Tetracycline, which is better, then the answer will not be unequivocal. Both of these drugs from the group of antibiotics have a similar mechanism of action. Levomycetin (or Chloramphenicol) acts more effectively by inhibiting the synthesis of bacterial proteins.

Tetracycline is most effective in the treatment of respiratory and urinary tract infections, severe infectious diseases such as brucellosis, pneumonia, and sexually transmitted infections.

Tetracycline: reviews

Alena T. 19 years old. Simferopol « Tetracycline ointment helped me get rid of acne. I tried so many expensive drugs, but only this antibiotic helped. I smeared my face at night and after a week the acne disappeared.

Konstantin P., 36 years old, Khabarovsk “My daughter had severe conjunctivitis, tea leaves did not help, I had to see a doctor. He prescribed Tetracycline ointment, which cured the child in three days.”

Leonid K. 27 years old, Khanty-Mansiysk. “I had severe bronchitis and only 100 mg tetracycline hydrochloride tablets saved me from possible pneumonia. Cured in a week."

Instructions for use:

Tetracycline is a bacteriostatic antibiotic from the tetracycline group. It has a wide spectrum of antibacterial action.

Release form and composition

Tetracycline is available in the following dosage forms:

• coated tablets: pink, round shape, biconvex (10 pcs. in blister packs, one or two packs in a cardboard bundle; 40 pcs. in dark glass jars, in a cardboard pack one bank);
• : yellow, homogeneous (10 g or 15 g in aluminum tubes, one tube in a cardboard bundle);
• eye ointment 1%: yellowish or yellowish-brown, homogeneous (2, 3, 5 or 10 g in aluminum tubes, one tube in a cardboard bundle).

Composition per 1 coated tablet:

• active ingredient: tetracycline - 0.1 g;
• auxiliary components: basic magnesium carbonate, calcium stearate, corn starch, gelatin, sucrose, tropeolin O, talc, dextrin, acid red dye 2C.

Composition per 1 g of ointment for external use:

• active ingredient: tetracycline - 0.03 g;
• auxiliary components: ceresin, vaseline, solid petroleum paraffin, sodium metabisulphite, anhydrous lanolin.

Composition per 1 g of eye ointment:

• active ingredient: tetracycline - 0.01 g;
• auxiliary components: vaseline, anhydrous lanolin.

Indications for use

Tetracycline in the form of film-coated tablets is used for the following infectious diseases caused by microorganisms sensitive to the drug:

• bronchitis, tracheitis, pneumonia, pleural empyema;
• otitis, stomatitis, tonsillitis, pharyngitis, gingivitis;
• endometritis, endocarditis, prostatitis;
• intestinal infections, pyelonephritis, cholecystitis;
• osteomyelitis;
• whooping cough, rickettsiosis, ornithosis, brucellosis, actinomycosis, gonorrhea, syphilis;
• blepharitis, conjunctivitis, trachoma;
• purulent infections of soft tissues;
• acne, furunculosis, folliculitis, infected eczema.

Tetracycline in the form of an ointment for external use is prescribed for purulent infections of soft tissues, acne, furunculosis, folliculitis and infected eczema.

Tetracycline in the form of an eye ointment is used for bacterial (including chlamydial) eye infections caused by antibiotic-sensitive microorganisms:

• trachoma;
• blepharitis;
• keratitis;
• meibomite (barley);
• blepharoconjunctivitis;
• keratoconjunctivitis.

Contraindications

Coated tablets

• leukopenia;
• children's age up to 8 years;
• second and third trimesters of pregnancy;

Tetracycline tablets should be used with caution in patients with renal insufficiency.

Ointment for external use 3%

• fungal skin lesions;
• children's age up to 11 years;
• increased individual sensitivity to the components of the drug.

Eye ointment 1%

• impaired renal and / or liver function;
• children's age up to 8 years;
• period of pregnancy;
• breastfeeding period;
• increased individual sensitivity to the components of the drug.

Method of application and dosage

Coated tablets

Tetracycline tablets are taken orally with plenty of water or other liquid.

For children and adolescents aged 8–18 years, the drug is prescribed at 6.25–12.5 mg / kg body weight four times a day or 12.5–25 mg / kg body weight twice a day.

• acne: 0.5–2 g per day in divided doses. With improvement in the condition, which is observed after about 3 weeks, the dose of the drug is gradually reduced to a maintenance dose of 0.125–1 g per day. Adequate disease remission can be obtained with tetracycline every other day or with intermittent treatment;
• uncomplicated endocervical, rectal and urethral infections, the causative agent of which is Chlamydia trachomatis: 0.5 g four times a day, the course of treatment is at least 7 days;
• brucellosis: 0.5 g four times a day (every 6 hours) for 3 weeks; during the first week, intramuscular injections of streptomycin are additionally performed (1 g twice a day), during the second week, streptomycin is administered once a day;
• syphilis: 0.5 g four times a day, the course of treatment is 15 (for early syphilis) or 30 (for late syphilis) days;
• uncomplicated gonorrhea: the initial dose is 1.5 g per day, then the drug is administered at 0.5 g four times a day for 4 days.

Ointment for external use 3%

Tetracycline in the form of an ointment is applied to areas of the skin affected by the infection, or used as a gauze bandage, which is applied to the problem area. The multiplicity of applying the ointment is 1-2 times a day. The gauze bandage is changed every 12-24 hours. The therapeutic course varies from 2-3 days to 2-3 weeks.

Eye ointment 1%

Tetracycline in the form of an eye ointment is applied topically. The drug is placed behind the eyelid. A single dose is a strip of ointment 0.5–1 cm long.

With trachoma, the ointment is applied every 2-4 hours or more often for 1-2 weeks. With a decrease in inflammation, the frequency of use of Tetracycline is reduced to 2-3 times a day. The general course of treatment is 1-2 months.

With blepharoconjunctivitis and blepharitis, the ointment is used 3-4 times a day. The course of treatment is 5-7 days.

With keratoconjunctivitis and keratitis, the frequency of use of the drug is 2-3 times a day, and the course of treatment is 5-7 days. If there is no improvement on the 3rd-5th day of therapy, you should seek medical advice.

With barley, eye ointment is applied at night. Duration of the course - until the signs of inflammation disappear.

Side effects

When taking tetracycline orally, adverse reactions from following systems and organs:

• digestive system: nausea, esophagitis, vomiting, gastritis, dysphagia, anorexia, glossitis, hypertrophy of the papillae of the tongue, ulceration of the duodenum and stomach, pancreatitis, diarrhea, intestinal dysbacteriosis, hepatotoxic effect, increased activity of liver enzymes;
• hematopoietic system: neutropenia, thrombocytopenia, hemolytic anemia;
• nervous system: instability or dizziness, increased intracranial pressure;
• immunopathological and allergic reactions: skin flushing, photosensitivity, angioedema, drug lupus erythematosus, maculopapular rash, anaphylactoid reactions;
• urinary system: hypercreatininemia, azotemia;
• other reactions: discoloration of tooth enamel in children, candidiasis, hyperbilirubinemia, superinfection, vitamin B deficiency.

When using an ointment for external use and eye ointment, allergic reactions (redness, slight burning and itching of the skin), swelling and hyperemia of the eyelids, photosensitivity and transient blurring of vision can be observed.

special instructions

During the period of treatment with Tetracycline, it is necessary to limit insolation, since photosensitivity may develop.

With prolonged use of the drug, the function of the liver, kidneys and hematopoietic organs should be periodically monitored.

Tetracycline can mask the symptoms of syphilis, therefore, if a mixed infection is likely, monthly (within 4 months) it is necessary to serological analysis.

In children during the period of tooth development, enamel hypoplasia and long-term staining of tooth enamel in a yellow-gray-brown color are possible. This effect is due to the fact that tetracyclines interact with calcium and form stable complexes with it in any bone-forming tissue.

To prevent hypovitaminosis during treatment with Tetracycline, it is advisable to additionally take brewer's yeast, vitamin K and B vitamins.

drug interaction

With external and topical application Tetracycline drug interaction not described.

When taking tetracycline orally, possible interactions should be considered:

• magnesium-, aluminum- and calcium-containing antacids, cholestyramine and iron preparations reduce the absorption of tetracycline;
• chymotrypsin increases the concentration of tetracycline and the duration of its circulation;
• retinol increases the likelihood of increased intracranial pressure.

With simultaneous use with indirect anticoagulants, the prothrombin index decreases; with penicillins and cephalosporins - the effectiveness of these drugs decreases; with estrogen-containing oral contraceptives - the contraceptive effect is reduced and the risk of breakthrough bleeding increases.

Analogues

Tetracycline analogues are: Tetracycline-AKOS, Tetracycline-LekT.

Terms and conditions of storage

Store in a dry, dark place at a temperature not exceeding 15 ° C (ophthalmic ointment), 20 ° C (ointment for external use) or 25 ° C (coated tablets). Keep away from children. Shelf life - 3 years.

Tetracycline tablets belong to the "antibiotic-tetracycline" group. The drug is released strictly on prescription, as it has an extensive list of indications and a potent composition. The drug is strictly contraindicated during pregnancy, as well as children who have not reached the age of 8.

Registration number: LS-000868

Brand name: Tetracycline

International non-proprietary name: tetracycline

Chemical name: (4S,4aS,5aS,6S, 12a3)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5 ,5а,b,11,12а-octahydrotetracene-2-carboxamide

Dosage form: coated tablets

Photo of tetracycline tablets on which the composition is indicated

Tablets tetracycline composition

Composition per 1 tablet:

active substance: tetracycline (in terms of active substance) - 100 mg;

excipients: sucrose -1.4 mg, talc - 1.4 mg, calcium stearate - 1.4 mg, corn starch - to obtain a tablet weighing 140 mg (without shell); shell composition: sucrose - 110.455 mg, dextrin - 2.8185 mg, gelatin - 0.875 mg, magnesium hydroxycarbonate - 2.92 mg, talc - 2.92 mg. dye azorubine E-122 - 0.0105 mg, dye quinoline yellow E-104 - 0.001 mg.

Description

Film-coated tablets, from light pink to dark pink, round shape with a biconvex surface. The cross section shows three layers.

Pharmacotherapeutic group: antibiotic-tetracycline

ATX code: J01AA07

Pharmacological properties

Pharmacodynamics

Bacteriostatic antibiotic from the tetracycline group. Violates the formation of a complex between the transfer RNA and the ribosome, which leads to the suppression of protein synthesis.

Active against gram-positive microorganisms: Staphylococcus spp. (including Staphylococcus aureus, including penicillinase-producing strains), Streptococcus spp. (including Streptococcus pneumoniae), Mycoplasma pneumoniae, Listeria spp., Bacillus anthracis, Clostridium spp., Actinomyces israelii; gram-negative microorganisms: Haemophilus influenzae, Haemophilus ducreyi, Bordetella pertussis, most enterobacteria: Escherichia coli, Enterobacter spp., including Enterobacteraerogenes, Klebsiella spp., Salmonella spp., Shigella spp. spp., Francisellatularensis, Borreiia burgdorferi, Brucella spp. (in combination with streptomycin), Chlamydia spp. (including Chlamydia trachomatis); with contraindications to the appointment of penicillins - Clostridium spp., Neisseria gonorrhoeae, Actinomyces spp.; it is also active against pathogens of venereal and inguinal lymphogranuloma, Treponema spp. Microorganisms resistant to tetracycline: Pseudomonas aeruginosa, Proteus spp., Serratia spp., most strains of Bacteroides spp. and fungi, viruses, group A beta-hemolytic streptococci (including 44% of Streptococcus pyogenes strains and 74% of Streptococcus faecalis strains).

Pharmacokinetics

Absorption - 75-77%, decreases with food intake, connection with plasma proteins - 55-65%. The time to reach the maximum concentration in the blood serum when taken orally is 2-3 hours (it may take 2-3 days to achieve a therapeutic concentration). Over the next 81, the concentration gradually decreases. The maximum concentration in the blood is 1.5-3.5 mg / l (to achieve a therapeutic effect, a concentration of 1 mg / l is sufficient). It is unevenly distributed in the body: the maximum concentration is determined in the liver, kidneys, lungs and in organs with a well-developed reticuloendothelial system - the spleen, lymph nodes. Concentration in bile is 5-10 times higher than in blood serum. In the tissues of the thyroid and prostate, the concentration of tetracycline corresponds to that found in plasma; in pleural, ascitic fluid, saliva, milk of lactating women - 60-100% plasma concentration. It accumulates in large quantities in bone tissue, tumor tissues, in dentin and enamel of milk teeth. Poorly penetrates the blood-brain barrier. With intact meninges, it is not detected in the cerebrospinal fluid or is found in a small amount (5-10% of the plasma concentration). In patients with diseases of the central nervous system, especially in inflammatory processes in the membranes of the brain, the concentration in the cerebrospinal fluid is 8-36% of the plasma concentration. Penetrates through the placental barrier breast milk. The volume of distribution is 1.3-1.6 l/kg. Slightly metabolized in the liver. The half-life is 6-11 hours, with anuria, 57-108 hours. In the urine, it is found in high concentrations 2 hours after ingestion and persists for 6-12 hours; for the first 12 hours, the kidneys excrete up to 10-20% of the dose. Smaller amounts (5-10% of the total dose) are excreted in the bile into the intestine, where partial reabsorption occurs, which contributes to the long-term circulation of the active substance in the body (enterohepatic circulation). Excretion through the intestines - 20-50%. With hemodialysis, it is removed slowly.

Tetracycline indications for use

Infectious diseases caused by microorganisms sensitive to tetracycline: pneumonia and respiratory tract infections caused by Mycoplasma pneumoniae, respiratory tract infections caused by Haemophilus influenzae and Klebsiella spp., bacterial infections urinary tract infections, skin and soft tissue infections, necrotizing ulcerative gingivostomatitis, conjunctivitis, acne, actinomycosis, intestinal amoebiasis, anthrax, whooping cough, brucellosis, bartonellosis, chancroid, cholera, chlamydia, uncomplicated gonorrhea, inguinal granuloma, venereal lymphogranuloma, listeriosis, plague, psittacosis, vesicular rickettsiosis, Rocky Mountain spotted fever, typhus, relapsing fever, syphilis, trachoma, tularemia yaws

Tetracycline contraindications

Hypersensitivity to tetracycline, drug components, pregnancy, lactation, children's age (up to 8 years), leukopenia, sucrase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption.

Carefully

Renal failure.

Use during pregnancy and lactation

Use during pregnancy and lactation is contraindicated.

Tetracycline tablets: analogues are cheaper

Tetracycline tablets: dosage and method of administration

Inside, drinking plenty of fluids, adults - 300-500 mg 4 times a day or 500-1000 mg every 12 hours. The maximum daily dose is 4000 mg. For acne: 500-2000 mg/day in divided doses. If the condition improves (usually after 3 weeks), the dose is gradually reduced to a maintenance dose - 100-1,000 r. Adequate remission of acne can be achieved with the use of the drug every other day or intermittent therapy.

Brucellosis B 500 mg every 6 hours for 3 weeks, simultaneously with intramuscular administration of streptomycin at a dose of 1000 mg every 11 hours for 1 week and 1 time per day for 2 weeks.

Uncomplicated gonorrhea: initial single dose of 1500 mg, then 500 mg every 6 hours for 4 days (total dose of 9000 mg).

Syphilis 500 mg every 6 hours for 15 days (early syphilis) or 30 days (late syphilis). Uncomplicated urethral, ​​endocervical and rectal infections caused by Chlamydia trachomatis - 500 mg 4 times a day for at least 5 days. Individuals with impaired renal function require %

Dosing regimen response

With creatinine clearance more than 50 ml/min 200-400 mg 2-3 times a day, with creatinine clearance 10-50 ml/min 200-400 mg 1-2 times a day, with creatinine clearance less than 10 ml/min 200 -400 mg once a day (under the control of kidney function). Children aged 8-12 years - 100-200 mg 3-4 times a day.

Tetracycline side effects

On the part of the digestive system: loss of appetite, vomiting, diarrhea, nausea, glossitis, esophagitis, gastritis, ulceration of the stomach and duodenum, hypertrophy of the papillae of the tongue, dysphagia, hepatotoxic effect, increased activity of "liver" transaminases, pancreatitis, intestinal dysbacteriosis, enterocolitis. From the nervous system: increased intracranial pressure, dizziness or unsteadiness, headache. On the part of the hematopoietic organs: hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia. From the urinary system: azotemia, hypercreatininemia. Allergic and immunopathological reactions: maculopapular rash, skin hyperemia, angioedema, anaphylactoid reactions, drug-induced systemic lupus erythematosus, photosensitivity. Others: superinfection, candidiasis, hypovitaminosis B, hyperbilirubinemia, discoloration of tooth enamel in children, stomatitis.

Overdose

Symptoms: increased severity of dose-dependent side effects, hepatotoxicity, accompanied by fatty degeneration of the liver, pancreatitis. Treatment: withdrawal of the drug, symptomatic therapy (there is no specific antidote), maintenance of vital functions.

special instructions

In connection with possible development photosensitivity requires limitation of insolation. With prolonged use, periodic monitoring of the function of the kidneys, liver, and hematopoietic organs is necessary. It can mask the manifestations of syphilis, and therefore, if a mixed infection is possible, monthly serological analysis is necessary for 4 months. All tetracyclines form stable complexes with Ca2 in any bone-forming tissue. In this regard, taking during the period of tooth development can cause long-term staining of teeth in a yellow-gray-brown color, as well as enamel hypoplasia. For the prevention of hypovitaminosis, vitamins of groups B and K, brewer's yeast should be prescribed.

Impact on ability to drive vehicles and other mechanisms

Persons experiencing side effects from the nervous system (headache, and dizziness) should refrain from driving vehicles or other potentially dangerous mechanisms.

Interaction with other drugs

In connection with the suppression of intestinal microflora, it reduces the prothrombin index (requires a decrease in the dose of indirect anticoagulants). Reduces the effectiveness of bactericidal antibiotics that disrupt the synthesis of the cell wall (penicillins, cephalosporins). Reduces the effectiveness of estrogen-containing oral contraceptives and increases the risk of breakthrough bleeding; retinol - the risk of developing an increase in intracranial pressure. Absorption is reduced by antacids containing Al3, Mg2 and Ca2, Fe preparations and cholestyramine. Chymotrypsin increases the concentration and duration of circulation.

Release form

Coated tablets, 100 mg. 10 tablets in a blister pack made of PVC film and aluminum foil. Two blister packs with instructions for use are placed in a cardboard box. Packaging for hospitals: 350 blister packs with an equal number of instructions for use are placed in a cardboard box.

Photo of a blister of tetracycline tablets 20 pieces

Storage conditions

In a dry, dark place at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Best before date

3 years. Do not use after the expiration date stated on the package.

Photo of tetracycline tablets on which the series is indicated and up to which these tablets are suitable

Terms of dispensing from pharmacies

On prescription.

Producer: Republican Unitary Enterprise "Belmedpreparaty", Republic of Belarus Legal address and address for accepting claims'

220007 Minsk, st. Fabricius, d 30 t./f.: (+37517) 2203716, e-mail:

Photo of tetracycline tablets on which the manufacturer is indicated

Tablets tetracycline abstract (instruction for use) in photos

Photo of instructions for use of tetracycline tablets, part 1

Photo of instructions for use of tetracycline tablets, part 2

Tetracycline tablets: drug reviews

Elena Stepanova, Krasnoyarsk

With the drug Tetracycline, I happen to be confronted, probably much more often than with other conventional drugs. I have diarrhea, my illness begins after I eat fruit. Summer, well, how can you not eat apples, cherries, plums, watermelon and everything else. During this period of the year, I cannot restrain myself, I know, of course, what will happen to me. So I went to the doctor and he prescribed me this drug. I drank two tablets of Tetracycline, and I did not have such frequent urges to the toilet, and now my stomach is not “bubbling” like that. Therefore, as the season of all delicious fruits begins, I systematically take this drug, and it helps me. The only bad thing is that you need to constantly take a prescription for it.

Irina Alekseeva, Belogorsk

I got sick with pharyngitis, and I felt so sorry. The fact is that I just started to get hysterical, because in a week we have to go on vacation on a package tour, and here I am with my pharyngitis. And you really want to go. My mother went to the doctor, he wrote a prescription for this drug. My mother brought Tetracycline to me, I took it for 5 days in the morning and in the evening, and I felt a little better. In addition, the doctor prescribed a few more remedies. In the end, I managed to recover and calmly went to rest on vacation. This drug just saved me, and many thanks to the doctor for writing a prescription without me and giving it to my mother.

Svetlana Loginova, Blagoveshchensk

My leg was inflamed (there was erysipelas). What ointments I just did not smear, but they did not give any effect. I read on the Internet what can help me, and it was written about Tetracycline tablets. I decided to try it, it won’t bring me any harm, even though it’s an antibiotic, I thought. I came to the pharmacy, and they tell me, give me a prescription. As it turned out, the drug is dispensed strictly by prescription from a doctor. To my surprise, he helped me. I drank it for 5 days, two tablets. And he got results!

Tatiana Fedoseeva, Zelenograd

I had a problem, my skin was covered with pimples. And my mother advised me Tetracycline tablets, told me to go to the doctor for a prescription. I drank them for three days, and my pimples practically disappeared. After drinking this drug for seven days, my acne disappeared.

Svetlana Olova, Novoaltaisk

The drug is just great for bronchitis. I have been looking for a drug for a long time that will not cause an allergic reaction in me. And so I found it. The only bad thing is that the drug is very strong, so you need to take a prescription from a doctor for it. But while you stand these queues to the doctor, you can just get off the amount. But I'd rather stand in line for a bit, but this antibiotic helps me a lot.

Ivan Dudkin, Moscow

The drug may be good, but I'm allergic to it. The whole body was completely covered with acne.

Anastasia Turova, Chrysostom

I had a sore throat, so much so that I had a complication. I had to go to the hospital. The doctor stabbed me like that there - just terrible, my fifth point hurt a lot. I sometimes felt that my soft spot hurt more than my throat. I told the doctor to put me on another drug. To me have appointed or nominated this antibiotic together with vitamins. The drugs helped me a lot. Many thanks to the doctor for the timely and high-quality treatment.

3 Comments

pro-tablets.ru

Tetracycline

Tetracycline - medicinal product antibacterial (bacteriostatic) broad spectrum of action.

Release form and composition

Tetracycline is available in the following forms:

• , 100 mg: biconvex, round, red, a yellow core is visible on the cross section (10 pieces in a blister pack, in a carton pack 1, 2 or 4 packs; 20 pieces in polymer cans, in a carton pack 1 can; 40 pieces in dark glass jars, 1 jar in a carton box);
• ointment for external use 3%: yellow (10 g or 15 g in aluminum tubes, 1 tube in a cardboard bundle; 15 g in polymer tubes, 1 tube in a cardboard bundle);
• eye ointment 1%: yellowish or yellowish-brown (2, 3, 5 or 10 g in aluminum tubes, 1 tube in a cardboard box).

Composition of 1 tablet:

• active ingredient: tetracycline hydrochloride - 100 mg;
• auxiliary components: microcrystalline cellulose, povidone, calcium stearate, potato starch, talc, sodium starch glycolate;
• film shell: polysorbate-80, hypromellose, titanium dioxide, silicone emulsion KE 10-16, tropeolin O dye, azorubine dye.

Composition of 1 g of ointment for external use:

• active ingredient: tetracycline hydrochloride - 30 mg;
• auxiliary components: solid petroleum paraffin, sodium disulfite, anhydrous lanolin, ceresin, vaseline.

Composition of 1 g eye ointment:

• active ingredient: tetracycline hydrochloride - 10 mg;
• auxiliary components: anhydrous lanolin, vaseline.

Indications for use

Film-coated tablets

• bronchitis, pneumonia, tonsillitis, pleural empyema, endocarditis;
• pyelonephritis, cholecystitis, intestinal infections;
• bacterial infections of the urogenital organs (prostatitis, endometritis, uncomplicated gonorrhea, syphilis, venereal lymphogranuloma, inguinal granuloma, chancroid);
• purulent infections of soft tissues;
• rickettsiosis, brucellosis, anthrax, intestinal amoebiasis, cholera, bartonellosis, actinomycosis, plague, listeriosis, typhus, ornithosis, relapsing fever, yaws, tularemia;
• osteomyelitis;
• acne;
• conjunctivitis, trachoma, blepharitis;
• prevention of postoperative infections.

Ointment for external use

• acne;
• furunculosis;
• folliculitis;
• eczema infected;
• purulent soft tissue infections.

Eye ointment

• barley;
• blepharitis;
• keratitis;
• blepharoconjunctivitis;
• keratoconjunctivitis;
• trachoma.

Contraindications

Film-coated tablets

• leukopenia;
• kidney failure;
• fructose intolerance, sucrase / isomaltase deficiency, glucose-galactose malabsorption syndrome;
• period of pregnancy;
• children's age up to 8 years;
• increased individual sensitivity to the main or auxiliary components of the drug.

Tablets are prescribed with caution to patients with a history of allergic reactions.

Ointment for external use

• fungal infections of the skin;
• kidney failure;
• period of pregnancy;
• breastfeeding period;
• children's age up to 11 years;

Eye ointment

• impaired renal and / or liver function;
• period of pregnancy;
• breastfeeding period;
• children's age up to 8 years;
• increased individual sensitivity to the components of the drug.

Method of application and dosage

Film-coated tablets

Tetracycline tablets are taken orally with plenty of water or other liquid.

The recommended dose for adult patients is 300-500 mg 4 times a day (every 6 hours) or 500-1000 mg 2 times a day (every 12 hours). The maximum dose is 4000 mg per day. The duration of therapy is from 5 to 10 days.

For children over the age of 8 years, the drug is prescribed at 6.25–12.5 mg / kg body weight 4 times a day (every 6 hours) or 12.5–25 mg / kg body weight 2 times a day (every 12 hours ).

• uncomplicated gonorrhea: 1500 mg once, then 500 mg 4 times a day (every 6 hours) for 4 days;
• uncomplicated rectal, endocervical and urethral infections caused by Chlamydia trachomatis: 500 mg 4 times a day for at least one week;
• syphilis: 500 mg 4 times a day for 15 days (for early syphilis) or 30 days (for late syphilis);
• venereal lymphogranuloma, inguinal granuloma: 500 mg 4 times a day for 3-4 weeks;
• brucellosis: 500 mg 4 times a day for 3 weeks with simultaneous intramuscular administration of streptomycin at a dose of 1000 mg 2 times a day during the first week and 1 time per day during the second and third weeks;
• listeriosis: 200-300 mg 4 times a day for 7-10 days;
• chlamydia: 1500–2000 mg per day for 10 days (with fresh forms) and 15–20 days (with chronic and complicated forms);
• actinomycosis: 3000 mg per day for the first 10 days of treatment, then 500 mg 4 times a day for 18 days;
• Lyme disease (only early stage): 1000-1500 mg per day for 10-14 days;
• ornithosis: 500 mg 4 times a day for 7-14 days;
• rickettsiosis: 800-1200 mg per day for 8-10 days;
• tularemia: 1500-2000 mg per day, treatment is continued for another 5-7 days after the temperature returns to normal;
• plague: up to 6000 mg per day, after improvement of the condition, the dose is reduced to 2000 mg per day until body temperature normalizes (but not less than 3 days); persons who have been in contact with the patient must undergo a prophylactic course (300 mg 4 times a day);
• yaws: 500 mg 4 times a day for 14 days;
• acne: 500-2000 mg per day in divided doses; when the condition improves (usually after 3 weeks), it is necessary to gradually reduce the dose to a maintenance dose of 100–1000 mg per day. Adequate remission of acne is achieved with intermittent treatment or the use of the drug every other day.

Ointment for external use

Tetracycline in the form of an ointment for external use is applied to the affected areas 1-2 times a day. It is possible to use a gauze bandage, which is changed 1-2 times a day. The duration of therapy varies from several days to 2-3 weeks.

Eye ointment

Tetracycline in the form of an eye ointment is applied topically. A strip of ointment 0.5-1 cm long is placed behind the eyelid.

Frequency of use and duration of treatment:

• barley: daily at night, the course of treatment - until the symptoms disappear;
• keratitis and keratoconjunctivitis: 2-3 times a day, course - 5-7 days;
• blepharitis and blepharoconjunctivitis: 3-4 times a day, course - 5-7 days;
• trachoma: every 2–4 hours or more often for the first 1–2 weeks; when the inflammation process subsides, the ointment is used 2-3 times a day for 1-2 months.

Side effects

Film-coated tablets

• digestive system: loss of appetite, nausea, vomiting, gastritis, glossitis, hypertrophy of the papillae of the tongue, pancreatitis, diarrhea, ulceration of the mucous membrane of the duodenum and stomach, enterocolitis, intestinal dysbacteriosis, hepatotoxic effect, increased activity of liver enzymes, antibiotic-associated diarrhea;
• hematopoietic system: thrombocytopenia, eosinophilia, hemolytic anemia, neutropenia;
• central nervous system: headache, increased intracranial pressure, toxic effect on the central nervous system (unstability or dizziness);
• urinary system: hypercreatininemia, azotemia, nephrotoxic effect;
• immunopathological and allergic reactions: skin flushing, photosensitivity, maculopapular rash, angioedema, drug-induced systemic lupus erythematosus, anaphylactoid reactions;
• other reactions: hypovitaminosis of B vitamins, discoloration of tooth enamel (in children), candidiasis, stomatitis, hyperbilirubinemia, superinfection.

Ointment for external use

Allergic reactions are possible: slight burning, itching, swelling, skin flushing, photosensitivity.

Eye ointment

• swelling and hyperemia of the eyelids;
• blurred vision (passes on its own);
• hypersensitivity reactions.

special instructions

During the period of treatment with Tetracycline, direct exposure to sunlight should be limited, since the drug can cause photosensitivity.

At long-term treatment it is necessary to periodically monitor the function of the liver, kidneys and hematopoietic organs.

Tetracycline can mask the symptoms of syphilis, therefore, if a mixed infection is likely, a serological analysis should be performed monthly for 4 months.

In order to prevent hypovitaminosis during treatment with Tetracycline, brewer's yeast and vitamins of groups B and K should be taken.

If there is no improvement within a few days, you should consult a doctor.

During the period of treatment with oral forms of Tetracycline, one should refrain from driving and engaging in other potentially hazardous activities.

drug interaction

When taken orally, the drug reduces the effectiveness of bactericidal antibiotics that disrupt the synthesis of the cell wall (cephalosporins, penicillins), and also reduces the therapeutic effect of oral contraceptives.

With simultaneous use with indirect anticoagulants, the prothrombin index decreases (a decrease in the dose of anticoagulants is required); with retinol - the risk of increased intracranial pressure increases; with chymotrypsin - increases the concentration and duration of tetracycline circulation.

The absorption of the drug is reduced when used together with colestyramine, antacids containing magnesium, calcium and aluminum ions, and iron-containing agents.

With external and local application of Tetracycline, drug interactions are not described.

Terms and conditions of storage

To store in the place protected from light at a temperature: no more than 15 °C (eye ointment); 20–25 °C (tablets and ointment for external use). Keep away from children.

Shelf life - 3 years.

medlib.net

Tetracycline tablets

Tetracycline in different dosage forms (tablets, ointment) is produced by different manufacturers. There are no synonyms.

Price

Average price online* 91 rub.

Where could I buy:

Instructions for use

Tetracycline is a common and affordable antibiotic with a wide spectrum of activity. This drug is included in the list of essential medicines by the World Health Organization.

Indications for use

The use of tetracycline is effective in the case of its appointment for infectious diseases caused by microorganisms sensitive to tetracycline. So, indications for the use of tablets are:

• infectious diseases of the respiratory tract and pneumonia caused by Klebsiella spp., Mycoplasma pneumoniae and Haemophilus influenzae;
• soft tissue and skin infections;
• actinomycosis;
• cholera;
• anthrax;
• vesicular rickettsiosis;
• bartonellosis;
• uncomplicated gonorrhea;
• typhus and relapsing fever;
• venereal lymphogranuloma;
• plague;
• tularemia;
• bacterial infections of the urinary organs;
• brucellosis;
• ulcerative necrotic gingivostomatitis;
• chlamydia;
• intestinal amoebiasis;
• chancroid;
• psittacosis;
• inguinal granuloma;
• listeriosis;
• spotted fever of the Rocky Mountains;
• syphilis;
• yaws.

Method of application and dosage

The drug must be taken orally, its dosage is determined by the age of the patient.

In the treatment of children whose age is over 8 years, 2 options for taking the drug are allowed:

• every 6 hours, 6.25-12.5 mg per 1 kg of body weight of the child;
• every 12 hours, 12.5-25 mg per 1 kg of body weight.

The duration of treatment in most cases is 5-7 days.

The diagnosis and condition of the patient serve as the basis for the doctor to determine the exact dosage and duration of therapy.

Contraindications

The drug can not be administered to pregnant and lactating women, as well as children under the age of eight. In addition, Tetracycline is contraindicated in persons suffering from:

• mycoses;
• liver failure;
• leukopenia;
• hypersensitivity to the components of the tablets.

Caution and control of the doctor requires the use of the drug in patients with impaired liver function.

Use during pregnancy and lactation

There is evidence that tetracycline can cross the placenta and accumulate in the rudiments of the teeth and bones of the unborn child, causing their demineralization. This can lead to severe pathologies in the development of bone tissue. That is why the drug is contraindicated during pregnancy.

If there is a need to take Tetracycline during lactation, breastfeeding must be stopped. Penetrating into milk, the drug can cause a child:

• violations of the development of teeth and bones;
• photosensitivity;
• candidiasis oral cavity and vagina.

Side effects

In some cases, the use of Tetracycline may be accompanied by the following side effects:

• from the side of the central nervous system: headaches and dizziness;
• from the digestive system: vomiting and nausea, constipation, abdominal pain, discoloration of the tongue, anorexia, esophagitis, glossitis, increased concentration of residual nitrogen and bilirubin, liver transaminase activity, alkaline phosphatase;
• from the hemopoietic system: thrombocytopenia, neutropenia, hemolytic anemia;
• dermatological reactions in the form of photosensitivity;
• allergic reactions: itching and skin rash, angioedema, eosinophilia;
• effects caused by the chemotherapeutic action of the drug: intestinal dysbacteriosis, candidal vulvovaginitis and candidal stomatitis;
• hypovitaminosis of B vitamins.

drug interaction

Absorption of tetracycline from gastrointestinal tract may decrease under the influence of:

• salts of calcium, iron, magnesium;
• antacids;
• cholestyramine.

Tetracycline, in turn, reduces the effectiveness of oral contraceptives and bactericidal drugs.

It is noted that the simultaneous administration of the drug with vitamin A increases the likelihood of developing intracranial hypertension.

special instructions

Long-term therapy with tetracycline requires mandatory monitoring of the liver, kidneys and hematopoietic organs.

The appointment of tetracycline to children during the period of growth and development of teeth can cause an irreversible change in the shade of tooth enamel.

Do not use tablets simultaneously with dairy products, as they reduce the absorption of the antibiotic.

Composition and pharmacokinetics

One tablet contains 100 mg of the active substance - tetracycline.

After taking the drug, 60-80% of the dose is absorbed from the gastrointestinal tract. Tetracycline is rapidly delivered in the blood to most organs and tissues of the body. It is excreted unchanged with feces and urine.

Other

On the this moment released without a prescription. Shelf life 3 years. Store in a dry place at a temperature not exceeding 25 °C.