Amosin appointment. Amosin: what helps, method of application and dose, contraindications

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In this article, you can read the instructions for use medicinal product Amosin. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of the Amosin antibiotic in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Amosin in the presence of existing structural analogues. Use for the treatment of tonsillitis, pneumonia, sinusitis and other infectious diseases in adults, children, as well as during pregnancy and lactation. The composition and interaction of the drug with alcohol.

Amosin- a broad-spectrum antibiotic of the group of semi-synthetic penicillins. Acts bactericidal. It inhibits transpeptidase, disrupts the synthesis of peptidoglycan (the supporting polymer of the cell wall) during division and growth, and causes bacterial lysis. Acid resistant.

Active against aerobic Gram-positive bacteria: Staphylococcus spp. (staphylococcus aureus) (with the exception of strains producing penicillinase), Streptococcus spp. (streptococcus); aerobic gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Bacillus anthracis, Listeria monocytogenes (listeria), Helicobacter pylori(helicobacter), Klebsiella spp. (Klebsiella).

Microorganisms producing penicillinase are resistant to the action of amoxicillin.

The action develops 15-30 minutes after administration and lasts 8 hours.

Compound

Amoxicillin (in the form of trihydrate) + excipients.

Pharmacokinetics

After oral administration, Amosin is rapidly and almost completely (93%) absorbed from the gastrointestinal tract. Eating does not affect the absorption of the drug, is not destroyed in the acidic environment of the stomach. It is found in high concentrations in plasma, sputum, bronchial secretions (poor distribution in purulent bronchial secretions), pleural and peritoneal fluid, urine, contents of skin blisters, lung tissue, intestinal mucosa, female genital organs, prostate gland, middle ear fluid, bones , adipose tissue, gallbladder(at normal function liver), fetal tissues. When the dose is increased by 2 times, the concentration also increases by 2 times. The concentration in bile exceeds the concentration in plasma by 2-4 times. In the amniotic fluid and vessels of the umbilical cord, the concentration of amoxicillin is 25-30% of the plasma level in a pregnant woman. Poorly penetrates the blood-brain barrier (BBB), with inflammation of the meninges (meningitis), the concentration in the cerebrospinal fluid is about 20%. Plasma protein binding - 17%. It is excreted in a small amount from breast milk. Amoxicillin is partially metabolized to inactive metabolites. Amoxicillin is excreted 50-70% unchanged in the urine by tubular excretion (80%) and glomerular filtration (20%), with bile - 10-20%.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

respiratory infections (including bronchitis, pneumonia);
ENT infections (including sinusitis, pharyngitis, tonsillitis, acute otitis media);
infections of the genitourinary system (including pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea);
gynecological infections (including endometritis, cervicitis);
infections of the digestive tract (including peritonitis, enterocolitis, typhoid fever, cholangitis, cholecystitis);
infections of the skin and soft tissues (including erysipelas, impetigo, secondarily infected dermatoses);
leptospirosis;
listeriosis;
Lyme disease (borreliosis);
dysentery;
salmonellosis, salmonellosis;
meningitis;
endocarditis (prevention);
sepsis.

Release form

Capsules 250 mg.

Tablets 250 mg and 500 mg.

Powder for suspension for oral administration 125 mg, 250 mg and 500 mg.

Instructions for use and dosage

The drug is taken orally, before or after a meal. The dosage regimen is set individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.

Adults and children over 10 years old (weighing more than 40 kg) are prescribed 500 mg 3 times a day, with severe course diseases - 0.75-1 g 3 times a day.

Children aged 5 to 10 years are prescribed 250 mg 3 times a day, aged 2 to 5 years - 125 mg 3 times a day, under the age of 2 years - 20 mg / kg per day in 3 divided doses. The course of treatment is 5-12 days.

For children under the age of 5 years, the drug is prescribed in the form of a suspension (ideal children's form of the drug).

For the treatment of acute uncomplicated gonorrhea, the drug is prescribed at a dose of 3 g once; in the treatment of women, repeated administration of the indicated dose is recommended.

For acute infectious diseases Gastrointestinal tract (paratyphoid, typhoid fever) and biliary tract, with gynecological infectious diseases, adults are prescribed 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

With leptospirosis, adults are prescribed 500-750 mg 4 times a day for 6-12 days.

With salmonella carriage in adults - 1.5-2 g 3 times a day for 2-4 weeks.

For the prevention of endocarditis in minor surgical interventions, adults are prescribed at a dose of 3-4 g 1 hour before the procedure. If necessary, a second dose is prescribed after 8-9 hours. In children, the dose is halved.

Rules for preparing a suspension from a single-dose package

Boiled and cooled water is poured into a clean glass in the amount indicated in the table, then the contents of one package are poured out and mixed until a homogeneous suspension is obtained.

The dose in the package is 125 mg - the required amount of water is 2.5 ml;
dose in a package of 250 mg - the required amount of water is 5 ml;
dose in a package of 500 mg - the required amount of water is 10 ml.

After taking the glass, rinse with water, dry and store in a dry, clean place.

Side effect

hives;
skin hyperemia;
erythema;
angioedema;
rhinitis;
conjunctivitis;
fever;
pain in the joints;
eosinophilia;
exfoliative dermatitis;
multiform exudative erythema;
Stevens-Johnson syndrome;
reactions similar to serum sickness;
anaphylactic shock;
dysbacteriosis;
taste change;
vomiting, nausea;
diarrhea;
stomatitis;
glossitis;
pseudomembranous enterocolitis;
excitation;
anxiety;
insomnia;
confusion;
behavior change;
depression;
peripheral neuropathy;
headache;
dizziness;
convulsive reactions;
interstitial nephritis;
leukopenia, neutropenia, thrombocytopenic purpura, anemia;
labored breathing;
tachycardia;
vaginal candidiasis;
superinfection (especially in patients with chronic diseases or reduced body resistance).

Contraindications

allergic diathesis;
bronchial asthma, hay fever;
Infectious mononucleosis;
lymphocytic leukemia;
liver failure;
a history of gastrointestinal disease (especially colitis associated with the use of antibiotics);
lactation period (breastfeeding);
hypersensitivity to the components of the drug;
hypersensitivity to other penicillins, cephalosporins, carbapenems;
children's age up to 3 years (for tablets and capsules).

Use during pregnancy and lactation

Use in children

Contraindicated in children under the age of 3 years (for the release form in the form of tablets and capsules). For children under the age of 5 years, the drug is prescribed in the form of a suspension.

special instructions

When conducting a course of treatment with Amosin, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

Perhaps the development of superinfection due to the growth of microflora insensitive to amoxicillin, which requires a corresponding change in antibiotic therapy.

When treating patients with bacteremia, a bacteriolysis reaction rarely develops (the Jarisch-Herxheimer reaction).

In patients with hypersensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

At treatment of mild diarrhea against the background of the use of Amosin, the appointment of antidiarrheal drugs that reduce intestinal motility should be avoided; kaolin- or attapulgite-containing antidiarrheals may be used. For severe diarrhea, it is necessary to differential diagnosis and prescribe appropriate therapy.

Treatment should be continued for another 48-72 hours after the disappearance clinical signs diseases.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, if possible, use additional methods contraception.

drug interaction

Antacids, glucosamine, laxatives, food, antibiotics of the aminoglycoside group, while used simultaneously, slow down and reduce the absorption of Amosin; ascorbic acid - increases its absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) show synergism with amoxicillin; bacteriostatic drugs (macrolides, chloramphenicol, lincosamines, tetracyclines, sulfonamides) - antagonism.

Amoxicillin, with simultaneous use, increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives, ethinyl estradiol (the risk of developing intermenstrual bleeding), as well as medicines, during the metabolism of which para-aminobenzoic acid is formed.

The joint use of the drug Amosin with alcohol is prohibited (the hepatotoxic effect of ethanol is enhanced).

Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, non-steroidal anti-inflammatory drugs (NSAIDs) and drugs that block tubular secretion, while used with Amosin, reduce tubular secretion, increase the concentration of amoxicillin.

With the simultaneous use of Amosin with allopurinol, the risk of developing a skin rash increases.

Amoxicillin with simultaneous use reduces clearance and increases the toxicity of methotrexate.

Amoxicillin with simultaneous use enhances the absorption of digoxin.

Analogues of the drug Amosin

Structural analogues for the active substance:

Amoxisar;
Amoxicillin;
Amoxicillin trihydrate;
Gonoform;
Grunamox;
Danemox;
Ospamox;
Flemoxin Solutab;
Hyconcil;
Ecoball.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases from which the corresponding drug helps and see the available analogues for the therapeutic effect.

Amosin is a semi-synthetic drug from the group of penicillins with broad spectrum antibacterial action.

Its effect is manifested in the inhibition of the transpeptidase enzyme, in the violation of the stability of the cell walls, inhibition of the development of pathogenic microorganisms and their division at the cellular level, which ultimately causes the lysis of the pathogenic microflora.

On this page you will find all the information about Amosin: full instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Amosin. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

An antibiotic of the penicillin group of a wide spectrum of activity, which is destroyed by penicillinase.

Terms of dispensing from pharmacies

Released by prescription.

Prices

How much does Amosin cost? The average price in pharmacies is at the level of 30 rubles.

Release form and composition

Amosin is available in several dosage forms.

Amosin gelatin capsules, white, size 0. The contents of the capsules are white granules. Packed in contour cells of 10 pieces.

Amosin tablets - white or almost white, flat cylindrical shape, with a separating risk and chamfer. Packed in contour cells of 10 pieces.

Amosin powder for suspension for oral administration - has a white color with a yellowish tinge and a specific smell. The prepared suspension is white with a yellowish tint and a specific smell. Packed in single-dose packages of 1.5; 3 and 6 years

Pharmacological effect

Active ingredient remedy actively affects gram-negative bacteria - Neisseria meningitidis and Listeria monocytogenes and Bacillus anthracis, Klebsiella spp., Neisseria gonorrhoeae and Helicobacter pylori; for gram-positive staphylococcal and streptococcal bacteria. The pathogenic microflora that produces penicillinase is immune to the effects of the active component of Amosin.

The effect of taking the therapeutic drug appears at 15-30 minutes and lasts 8 hours. The drug is easily and within a short time absorbed by the walls of the gastrointestinal tract, and the presence of food in it does not affect the rate of absorption. The maximum content of amoxicillin is reached in the blood plasma in the first 1-2 hours. The blood flow brings the active ingredient of the drug to the mucous organs, bone and connective tissue, intraocular sputum and fluid. The time of excretion of the drug through the kidneys averages from two to three hours and may increase in patients with impaired renal function.

Indications for use

The antibiotic Amosin is prescribed for bacterial infections:

Urogenital infections (cystitis, pyelonephritis, urethritis, pyelitis, gonorrhea);
Infectious diseases of the digestive tract (dysentery, abdominal type, salmonellosis, cholecystitis);
Borreliosis;
Meningitis;
Acute infections of the upper respiratory tract;
Acute infectious diseases of the lower respiratory tract (bronchitis, pneumonia);
Infections of ENT organs (acute otitis media, sinusitis, tonsillitis);
Sepsis;
Diseases of the skin and soft tissues (secondary infected dermatosis, impetigo, erysipelas);
Prevention of endocarditis and surgical infection.

Contraindications

Contraindications to the use of Amosin are:

Liver failure;
Bronchial asthma and hay fever;
Allergic diathesis;
lymphocytic leukemia;
Infectious mononucleosis;
Diseases of the gastrointestinal tract;
Hypersensitivity to amoxicillin and other penicillins, as well as carbapenems and cephalosporins;
The period of breastfeeding;
Children's age up to 3 years (for dosage form in the form of capsules and tablets).

With caution, Amosin is prescribed to pregnant women and patients with kidney failure and a history of bleeding.

Use during pregnancy and lactation

The use of the drug during pregnancy is possible only in cases where the intended benefit of therapy for the mother outweighs the potential risk to the fetus.

Use during lactation is contraindicated. If necessary, use during lactation should be discontinued. breast-feeding.

Instructions for use Amosin

The instructions for use indicate that Amosin is taken orally, before or after a meal. The dosage regimen is set individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.

Adults and children over 10 years old (weighing >40 kg) are prescribed 500 mg 3 times / day, in severe cases of the disease - 0.75-1 g 3 times / day.
Children aged 5 to 10 years are prescribed 250 mg 3 times / day, aged 2 to 5 years - 125 mg 3 times / day, under the age of 2 years - 20 mg / kg / day in 3 divided doses. The course of treatment is 5-12 days.
For children under the age of 5 years, the drug is prescribed in the form of a suspension.

For treatment of acute uncomplicated gonorrhea the drug is prescribed in a dose of 3 g once; in the treatment of women, repeated administration of the indicated dose is recommended.

At acute infectious diseases of the gastrointestinal tract (paratyphoid, typhoid fever) and biliary tract, with gynecological infectious diseases adults are prescribed 1.5-2 g 3 times / day or 1-1.5 g 4 times / day.

At leptospirosis adults are prescribed 500-750 mg 4 times / day for 6-12 days.

At salmonella carrier adults - 1.5-2 g 3 times / day for 2-4 weeks.

For prevention of endocarditis in minor surgical interventions adults are prescribed at a dose of 3-4 g 1 hour before the procedure. If necessary, a second dose is prescribed after 8-9 hours. In children, the dose is halved.

In patients with impaired renal function (CC from 15 to 40 ml / min), the interval between doses is increased to 12 hours, in the terminal stage of chronic renal failure (CC

When a child is very ill, only a competent doctor can help. With luck, the child will get off with several doses of antiviral drugs. If the doctor has even the slightest concern about possible complications He will most likely prescribe an antibiotic.

Recently, according to the Ministry of Health, seasonal "sores" mutate and are more severe, especially in children aged 2-3 years. It was at this time that kids begin to attend kindergarten, actively explore the world, and contact with peers. And there is a fertile soil for the mutual exchange of bacteria. As a result, mom has to go on sick leave with enviable regularity.

What diseases lie in wait most often for a small person? Local pediatricians know the answer to this question for sure. The most common among children in winter and in the off-season are bronchitis, tonsillitis, pharyngitis, various forms of otitis, tonsillitis. If a child rolls on an ice slide or skating rink, another nuisance can happen - hypothermia often causes inflammation of the genitourinary system. The doctor's conclusion then sounds different - cystitis, pyelonephritis. Babies often suffer intestinal diseases(they are usually "brought" from the kindergarten). There is an exit. In all these unpleasant cases, the modern broad-spectrum antibiotic Amosin effectively helps.

What it is?

Let's try to explain this in simple terms. If your child is reluctant to take this drug now, read this and then tell him the tale of the courageous protector of all sick children Amosin. Believe me, you will no longer have to persuade the baby to take the next dose. He will gladly drink the medicine himself.

So, "Amosin 250" is a modern broad-spectrum antibiotic. It is closely related to semi-synthetic penicillins. Works like a riot police - quickly and decisively. The active substance is amoxicillin. Its goal is harmful microbes of various origins. The drug enters the body, after 15-20 minutes it penetrates the cell of a harmful bacterium and reduces the speed of all chemical processes that occur in it. Destroys the structure, membrane, enzymes.

The "evil" cell also wants to live, it begins to actively resist and, as a result, spends the last of its strength. "Amosin" is adamant. Its action lasts up to 8 hours. Some "enemy" cells try to attack it with acid. But the valiant antibiotic is resistant to it. So he wins 100% of the time. It is excreted from the body rather quickly, with the formation of inactive metabolites. This means that the decay products are not toxic.

In addition to otitis media, bronchitis and a host of other colds, the remedy successfully copes with such “serious” rivals as sinusitis, salmonellosis and meningitis. Deals with infections skin. Most often, the drug is recommended specifically for angina, since this disease is caused by bacteria of various types.

Instructions for use

"Amosin 250" is different: powder, granules. There is a solution for intramuscular and intravenous use. But for children, most often the remedy is prescribed in tablets. Babies aged 2-3 years are usually recommended to take an antibiotic in the form of a suspension. It is easy to drink, it is quite pleasant in taste and smell due to the vanillin added by the manufacturer to the main composition. In the form of syrup "Amosin" is not available.

The drug in the form of a suspension is the best choice for a child 2-3 years old

The dosage is determined by the doctor. It depends on the age of the child. "Amosin 250" can be given even to newborns from the first days of life.

Parents will have to prepare the suspension for children on their own. To do this, the powder is simply added to chilled boiled water. "Amosin 125" (drug containing active active ingredient in the amount of 125 mg) should be diluted in 2.5 ml. water. For a 250 mg product, 5 ml of water will be required, respectively. For 500 mg - 10 ml. liquids.

The dosage and schedule of administration is usually the same.

Babies from birth to 2 years old: three times a day. The total daily dosage is 20 mg suspension per kilogram of patient weight.
Preschoolers up to 5 years old inclusive can take 125 mg. suspension three times a day.
Children from 5 to 10 years old: three times a day, 250 mg.
Schoolchildren over 10 years old 500 mg of "Amosin" also three times a day.

Tablets and capsules of the drug are not given to children under 2 years old!

Sometimes "Amosin" is prescribed to children for the prevention of endocarditis or surgical infection. In this case, doctors recommend starting with half the adult dose.

The dosage of Amosin 250 is chosen only by the doctor after examining the child. Contraindications

Be sure to tell the doctor who prescribes Amosin to your child if the baby has at least one of these diseases:

allergic diathesis;
allergy to flowering (hay fever);
bronchial asthma;
liver failure;
kidney disease;
recurrent bleeding.

All these diagnoses are a strict contraindication to taking this antibiotic.

The drug should not be taken also by children who have ever had colitis or are allergic to antibiotics.

Amosin 250 affects and destroys various types of bacteria Side effects

Do not forget that, like any powerful antibiotic, the remedy can cause side effects. The instructions for use describe the following symptoms:

disorders of the gastrointestinal tract;
nausea;
allergic rhinitis;
the appearance of a rash and itching;
shortness of breath, sleep disturbance, depression of the central nervous system, tearfulness of the child.

If your son or daughter has at least one of the above, be sure to tell the doctor about it - he will adjust the dosage and give the necessary recommendations.

Overdose

If it so happens that the child has taken a dose of the drug in excess of that prescribed by the doctor, carefully observe him. " ambulance» should be called when symptoms such as nausea, severe vomiting, abdominal pain, dizziness appear. Only emergency specialists can help in this situation, because a powerful antibiotic acts quickly, and there is simply no antidote for it. Doctors will promptly wash the stomach with saline and remove the intoxication of the body. Self-medication in this case is extremely dangerous.

"Amosin" is more than affordable. Its average cost in Russian pharmacies is about 70 rubles (sachets for preparing a suspension), 27-40 rubles (tablets). A little more than 60 rubles is the drug in capsules. Prices in different regions of the country and pharmaceutical chains may differ, however, slightly.

Amosin tablets and capsules are not given to children under 2 years of age. Shelf life and storage conditions

The drug should be stored in a place protected from moisture and direct sunlight, at a temperature not higher than + 25C and not lower than + 15C, no more than 2 years from the date of manufacture. The drug is released strictly according to the prescription.

Amosin 250 is an antibiotic of domestic production. The manufacturer is the pharmaceutical company Sintez AKO JSC (Kurgan region).

The situation with analogues is quite interesting. Usually the original drug is more expensive than analogues. But here it's the other way around. Preparations with similar action are:

Flemoxin Solutab. Produced in Holland. A pack of tablets (20 pieces) costs more than 300 rubles.

Augmentin. An antibiotic of bacterial action comes from England. A pack of tablets (20 pieces) costs more than 250 rubles. By the way, pediatricians often like to prescribe Augmentin to their patients. In order not to overpay, it makes sense for parents to check with the doctor if it can be replaced with our original Amosin, which costs almost 5 times cheaper.

Amoxiclav. Another drug with a similar effect. Produced in Slovenia. It costs more than other analogues. For a package of 14 tablets, you will have to pay 250 rubles.

Reviews

On the Internet, the drug Amosin is known and most often approved. Since doctors have recently begun to prescribe it more often, parents already have some experience in using antibiotics to treat children. The main part of those who published their impressions of the drug emphasize that the main advantage of the drug is in the speed of its action. On the first day after the start of admission, the child's temperature drops, and after 5-6 days the baby is healthy. Moms cannot but rejoice, as they have to spend less time on sick leave. Almost everyone notes that this is a worthy alternative to expensive imported medicines.

Some parents note that during treatment with Amosin, their tummy hurts and digestion is disturbed. In this case, funds for restoring the intestinal microflora, such as Bifidumbacterin, Laktiale, etc., are saved. The doctor will also prescribe them.

Only a small part of mothers and fathers complain of sleep disturbances in a child while taking an antibiotic. And a few units - faced side effects drug.

Some parents avoid taking antibiotics by all means, even if they are strongly recommended by a doctor. But when prescribing a doctor, they should not be afraid.

Helping the baby to overcome the disease as soon as possible is the main task of caring parents. And when the child is healthy again, life in the house returns to its usual course, with its small joys and daily children's discoveries. Let the kids smile!

You can learn more about antibiotics from the program of Dr. Komarovsky.

Instructions for the use of amosin tablets, a description of the action of the drug, indications for the use of amosin tablets, interaction with other drugs, the use of amosin (tablets) during pregnancy. Instructions:

Amosin in powder

The composition of amosin tablets

One tablet contains

Bir tabletkanyn kuramynda

The active substance of amosin

amoxicillin trihydrate (in terms of amoxicillin) 250 mg, 500 mg

amoxicillin trihydrates (amoxicilling shakanda) 250 mg, 500 mg

Excipients in Amosin

potato starch, magnesium stearate, talc, povidone, calcium stearate

potato starches, magnesium stearates, talc, povidone, calcium stearates

Indications for the use of amosin tablets

bronchitis, pneumonia

sinusitis, pharyngitis, tonsillitis, acute otitis media

pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis

cholangitis, cholecystitis, dysentery, salmonellosis, salmonella carriage

erysipelas, impetigo, secondarily infected dermatoses

leptospirosis

listeriosis

Lyme disease (borreliosis)

endocarditis (prevention)

bronchitis, pneumonia

sinusitis, pharyngitis, tonsillitis, zhedel ortangy otitis

pyelonephritis, pyelitis, cystitis, urethritis, pops, endometritis, cervicitis

cholangitis, cholecystitis, dysentery, salmonellosis, salmonellosis tasymaldaushylykta

tіlme, impetigo, ekіnshіley zhұқtyrylғan dermatozdard

leptospirosis

listeriosis

Lyme auruynda (borreliosis)

endocarditis (aldyn alu)

Amosin contraindications in tablets

hypersensitivity to the drug (including other penicillins, cephalosporins, carbapenems)

children's age up to 6 years (for this dosage form)

lactation period

drug (sonyn ishinde baska penicillinderge, cephalosporinderge, carbapenemderge) asa zhogary sezimtaldyk

6 zhaska deying_ balalarga (osy darіlіk tur ushіn)

lactation

Side effects of amosin tablets

dysbacteriosis, change in taste, stomatitis, glossitis, vomiting, nausea, diarrhea, moderate increase in the activity of "liver" transaminases

pseudomembranous enterocolitis

agitation, anxiety, insomnia, ataxia, confusion, behavior change, depression, peripheral neuropathy, headache, dizziness, epileptic reactions

leukopenia, neutropenia, thrombocytopenic purpura, anemia

urticaria, skin hyperemia, erythematous rashes, angioedema, rhinitis, conjunctivitis; rarely - fever, arthralgia, eosinophilia, exfoliative dermatitis, exudative erythema multiforme (including Stevens-Johnson syndrome), reactions similar to serum sickness, very rarely - anaphylactic shock

other: vaginal candidiasis, shortness of breath, tachycardia, interstitial nephritis, superinfection (especially in patients with chronic diseases or reduced body resistance)

dysbacteriosis, dam sezudin ozgerui, stomatitis, glossitis, zhүrek ainu, құsu, diarrhea, "bauyr"

zhalgan zhargakhshaly enterocolitis

қozu, үreylenu, ұyқysyzdyқ, ataxia, sananyң shatasuy, minez-құlyқ өzgeruі, depression, shetkergі neuropathy, bass auyru, bass ainalu, epilepsialyk reactional

leukopenia, neutropenia, thrombocytopenia purpura, anemia

esekzhem, teri hyperemia, erythematosus börtpeler, angioneuroticalyk іsіnu, rhinitis, conjunctivitis; Sirek: kyzba, arthralgia, eosinophilia, exfoliative dermatitis, exudative erythema multiformals (sonyn ishinde Stevens-Johnson syndromes), sarysu құyu auryna ұқsas reakialar, өte sirek — anaphylactic shock

baskalary: kynaptyk candidiasis, tynystyn taryluy, tachycardia, interstitial nephritis, askyn zhұқpa

Special instructions for use

With caution: allergic diseases (including history), diseases of the gastrointestinal tract in history (especially colitis associated with the use of antibiotics), renal failure, severe liver dysfunction, infectious mononucleosis, lymphocytic leukemia.

During the course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

Perhaps the development of superinfection due to the growth of microflora insensitive to it, which requires a corresponding change in antibiotic therapy.

When administered to patients with sepsis, it is possible to develop a bacteriolysis reaction (Jarish-Herxheimer reaction) (rarely).

In patients with hypersensitivity to penicillins, cross-allergic reactions with other beta-lactam antibiotics are possible.

In the treatment of mild diarrhea against the background of course treatment, antidiarrheal drugs that reduce intestinal motility should be avoided; kaolin- or attapulgite-containing antidiarrheals may be used. For severe diarrhea, see a doctor.

Treatment necessarily continues for another 48-72 hours after the disappearance of clinical signs of the disease. With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, other or additional methods of contraception should be used whenever possible.

Pregnancy and lactation

The use of the drug during pregnancy is possible when the expected benefit to the mother outweighs the potential risk to the fetus. If necessary, the appointment of the drug during lactation should stop breastfeeding.

Features of the effect of the drug on the ability to drive vehicle or potentially dangerous mechanisms

There were no reports of the effect of amoxicillin on driving or operating machinery. However, some patients may experience headache and dizziness. When they occur, the patient must take special precautions when driving and working with mechanisms.

Saқtyқpen: allergicalyқ aurular (sonyң ishіnde syrtartқydaғy), syrtқydaғy asқazan-ishek zholy aurulary (аsіrese, antibiotic қoldanumen baylanysty colitis), bүirek zhetkіlіkіksіzdіgі, bauyr funktsijasynynаңаңырңырңырңырңырңырңырңыр қ қ і қ қ е а r y

Kurstyk emdeude қan tuzu aғzalarynyn, bauyr zhәne bүyrek funktsiyasynyn zhagdayyn baқylap otyru kazhet.

Darіge sezіmtal emes mikrofloranyң өsuіnen asқyn zhұқpanyң damuy mүmkin, bұl bacteriumға қаrsy emdі tiіsіnshe өzgertudі talap etedі.

Sepsispen science tagaiyndalganda bacteriolysis reactionarynyn (Yarish-Gerksheimer reaction) damui mukin (sirek).

Penicillinderge zhogary sezimtaldygy bar emdelushilerde baska beta-lactamdy antibiotictermen aiqaspaly allergic reactionary boluy mүmkin.

Kurstyk emdeu ayasynda zhenil diarrhoea emdegende ishek peristaltikasyn tömendetetin diarrhea karsy preparationtardan aulak bolu kerek; құramynda kaolin nemese attapulgite bar diarrheaғa karsy darіlerdi paydalanuga bolady.

Auyr diarrheada darіgerge karalu kazhet.

Emdeu aurudyn klinikalyk belgileri basylgannan keyin mindetti turde tagy 48-72 sagat zhalgasady.

Kuramynda estrogen bar іshuge arnalgan contraceptive men amoxicillin bir mezgіlde қoldanylғanda mүmkindіgіnshe basқa nemese kosymsha contraception adіsterіn paidalanu kerek.

Zhuktilik zhane lactation kezen

Zhuktilik kezinde preparations ana ushin bolzhanatyn paydasy ұryққa tonetin zor қaterden artyқ bolatyn zhagdayda ғana koldanuғa bolady.

Dаrіlіk zattyң kөlіk құralyn nemese қаuіptіlіgі zor mechanism derdi baskaru kabіletіne аser etu erekshelіkterі

Amoxicillin avtokolіk baskaruғa nemese mechanismdermen zhұmys іsteuge aser etui zhonіnde khabarlamalar bolmaғan. Degenmen de, keibir emdelushilerde bas auyru zhane bas ainalu boluy mumkin. Olar bіlіngende emdelushі avtokolіk baskarganda zhane mechanismdermen zhұmys іstegende erekshe saktanu sharalaryn қadagalauy tiіs.

Dosage and method of application

Inside, take regardless of the meal. The tablet can be swallowed whole, divided into parts or chewed with a glass of water.

Adults and children over 10 years old(weighing more than 40 kg) appoint 500 mg 3 times a day; in severe infections - 750-1000 mg 3 times a day.

Children aged 6-10 years appoint 250 mg 3 times a day; in severe infections - 60 mg / kg / day 3 times a day. The course of treatment is 5-12 days.

For acute uncomplicated gonorrhea appoint 3000 mg once; in the treatment of women, it is recommended to repeat the indicated dose every other day.

In acute infectious diseases of the gastrointestinal tract(paratyphoid, typhoid fever) and biliary tract, with gynecological infectious diseases for adults - 1500-2000 mg 3 times a day or 1000-1500 mg 4 times a day.

With leptospirosis adults - 500-750 mg 4 times a day for 6-12 days.

With salmonella adults - 1500-2000 mg 3 times a day for 2-4 weeks.

For the prevention of endocarditis in minor surgical interventions adults - 3000-4000 mg 1 hour before the procedure. If necessary, a second dose is prescribed after 8-9 hours. In children, the second dose is reduced by 2 times.

In patients with impaired renal function with CC 15-40 ml / min, the interval between doses is increased to 12 hours; with CC below 10 ml / min, the dose is reduced by 15-50%; with anuria - the maximum dose of 2000 mg / day.

Ishke, as ishuge baylanyssyz kabyldanady. Tablets bіr staқan sumen іshіp, butіndey zhutuғa, ekіge bөluge nemese shainauғa bolada.

Eresekterge zhane 10 zhastan ulken (dene salmagy 40 kg-den köp) balalarga tauligine 3 ret 500 mg tagayyndalada; zhұқpanyn auyr agymynda - tәulіgіne 3 ret 750-1000 mg.

6-10 zhastagy balalarga tәulіgіne 3 ret 250 mg-den tagayyndalada; zhұқpanyn auyr agymynda - tәulіgіne 3 ret 60 mg/kg/tәulik. Emdeu courses 5-12 kn.

Zhedel askynbagan coz kezinde bir ret 3000 mg tagayyndalada; әyelderdi emdegende kөrsetіlgen dozany kүnara kaita қabyldau ұsynylady.

Askazan-ishek zholynyn (paratyphter, ish suzegі) zhane ot shygaru zholdarynyn

Leptospiroza eresekterge - 6-12 kun boi tәulіgіne 4 ret 500-750 mg.

Salmonella tasymaldaushylykta eresekterge - 2-4 apta boi tәulіgіne 3 ret 1500-2000 mg.

Shagyn surgery aralasularda endocardittin aldyn alu ushin eresekterge - emshara zhasaluynan 1 sagat buryn 3000-4000 mg. It seems bolsa, 8-9 sagattan son kaytalau dozasy tagayyndalada. Balalarda kaytalau dozasyn 2 yes azaitady.

Buyrek funktsiyasy buzylgan emdelushilerde KK 15-40 ml/min CC 10 ml / min tomen bulganda dosed 15-50% of azaitady; anuriyada - en zhogary dozasy 2000 mg / tablet.

Drug Interactions

Antacids, glucosamine, laxative drugs, food, aminoglycosides slow down and reduce absorption; ascorbic acid increases absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) have a synergistic effect; bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonistic.

Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives; drugs, in the process of metabolism of which para-aminobenzoic acid is formed, ethinyl estradiol - the risk of developing breakthrough bleeding.

Amoxicillin reduces clearance and increases the toxicity of methotrexate; enhances the absorption of digoxin.

Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, non-steroidal anti-inflammatory drugs, and other drugs that block tubular secretion increase the concentration of amoxicillin in the blood.

Allopurinol increases the risk of skin rashes.

Antacidter, glucosamine, ish zhurgizgish darilik zattar, tamaq, aminoglycoside sіnіrіluin bayaulatada zhane tömendetedі; ascorbin kyshkyly siniriluin arttyrady.

Bactericidal antibiotic (sony ishinde aminoglycoside, cephalosporinder, vancomycin, rifampicin) synergistic; bacteriostatical darilik zattar (macrolide, chloramphenicol, lincosamide, tetracyclinder, sulfanilamide) antagonist aser corseted.

Tikeley emes anticoagulanttar tiimdіlіgіn arttyrady (іshek mikroflorasyn bәsendetumen, K vitamin synthesis zhane prothrombin indexіn tоmendetedі); kuramynda estrogen bar ishuge arnalgan contraceptive terdin; metabolism of үderisinde paraaminobenzoic қyshқyly tүzіletіn dаrіlіk zattardyn, ethinyl estradioldyn tiimdіlіgіn azaitady – “құyylғan” қan ketulerdin damu қаupі.

Amoxicillin methotrexattyn clearance azaityp, uyttylygyn arttyrady; digoxin sinuin cosheyted.

Diureticter, allopurinol, oxyphenbutazone, phenylbutazone, kabynuga karsy steroids emes drug zhane ozekshelik secretions bogeytin baska da darіlіk zattar kanandagy amoxicillin concentrationsyn zhoғarylatady.

Allopurinol teri bortpesinin lady kaupin arttyrady.

Overdose of amosin tablets

Symptoms: nausea, vomiting, diarrhea, violation of water and electrolyte balance (as a result of vomiting and diarrhea).

Treatment: gastric lavage, activated charcoal, saline laxatives, drugs to maintain water and electrolyte balance; hemodialysis.

Symptoms Key words: Zhurek Ainu, құsu, diarrhea, su-electrolyte teңgerimіnіn bұzyluy (құsu zhane diarrhea saldarynan).

Emі: asqazandy shayu, belsendirilgen komir, tuzdy ish zhүrgіzgіshter su-electrolyte tengerimin saktap turuғa arnalғan dаrіlіk zattar; hemodialysis.

Pharmacological properties

Pharmacokinetics

Absorption is fast, high (93%), food intake does not affect absorption, is not destroyed in the acidic environment of the stomach. When taken orally at a dose of 125 and 250 mg, the maximum concentration is 1.5-3 and 3.5-5 mcg / ml, respectively. The time to reach maximum concentration after oral administration is 1-2 hours.

It has a large volume of distribution: it is found in high concentrations in plasma, sputum, bronchial secretions (in purulent bronchial secretions, the distribution is weak), pleural and peritoneal fluid, urine, contents of skin blisters, lung tissue, intestinal mucosa, female genital organs, prostate, middle ear fluid (with inflammation), bone, adipose tissue, gallbladder (with normal liver function), fetal tissues. When the dose is increased by 2 times, the concentration also increases by 2 times.

The concentration in bile exceeds the concentration in plasma by 2-4 times. In the amniotic fluid and vessels of the umbilical cord, the concentration of amoxicillin is 25-30% of the level in the plasma of a pregnant woman. Poorly penetrates the blood-brain barrier, but with inflammation of the meninges, the concentration in the cerebrospinal fluid is about 20% of the plasma level. Communication with plasma proteins - 17%. Partially metabolized to form inactive metabolites. The half-life is 1-1.5 hours. It is excreted by 50-70% by the kidneys unchanged (by tubular secretion - 80% and glomerular filtration - 20%), by the liver - 10-20%. A small amount is excreted in breast milk. In case of impaired renal function (creatinine clearance (CC) less than or equal to 15 ml / min), the half-life increases to 8.5 hours.

Amoxicillin is removed by hemodialysis.

Sіnіrіluі – zhyldam, zhogary (93%), as іshu sіnіrіluіne ykpalyn tigіzbeydi, asқazan қyshқyldy ortasynda ydyramaydy. 125 mg zhane 250 mg dose of іshke kabyldағanda en zhogary concentrations, tiіsіnshe, 1.5-3 µg/ml zhane 3.5-5 µg/ml. Іshu arkyly kabildagannan keyin en zhogary concentration of son uakyty - 1-2 sagat.

Taralu kөlemі үlken: zhoғary kontsentratsiyalarda plazmadan, қaқyryқtan, bronchus sekretіnen (іrіңdі bronchus sekretіnde taraluy әlsіz) plevralyқ zhane peritonealdі sұyyқtyқtan, nesepten, terі kүldіreuіkterіnің іshіndegіsіnen, өkpe tіnderіnen, іshektің shyryshty қabyғynan, әyeldің zhynys aғzalarynan, қuyқ Asta bezіnen, ortaңғy құlaқ sұyyқtyғynan ( ol kabynganda), suyekten, may tininen, öt kabynan (kalypty bauyr funktsiyasynda), ұryk tіnderіnen tabylady. Dozany 2 esege arttyrganda concentrations yes 2 ese ulgayady.

Өтэгі concentrations of plasma concentration synan 2-4 es asyp ketedі. Amnioticalyk suyyktykta zhane kіndіk tamyrlarynda amoxicillin concentrations - zhuktі аyel plazmasyndaғy deңgeidіn 25-30%. Hematoencephalic boget arkyly nashar ötedі, mi kabyktarynyn kabynuynda zhulyn suyyktygyndagy concentrations - plasmadgy dengeyinen 20% zhuyk. Plasma akuyzdarymen baylanysy - 17%. Belsendi emes metabolitter tuzumen ishinara metabolizdenedi. Zhartylai shygarylu kezeni - 1-1.5 sagat.

Ozgerіssіz kuyde bүyrekpen 50-70% (оzekshelіk secretion zholymen - 80% zhane shumaktyk suzіlіster arkyly - 20%), bauyrmen 10-20% shygarylady. Azdagan molsherde ana sүtimen bolіnedі. Buyrek funktsiyasynyn buzyluynda (creatinine clearance (CC) 15 ml/minuttan az nemese ogan ten) zhartylai shygarylu kezeny 8.5 sagatka deyin ұzarady. Amoxicillin hemodialysis kezinde shygarylady.

Pharmacodynamics

Amosin® is a broad-spectrum bactericidal antibiotic from the group of semi-synthetic penicillins. Violates the synthesis of peptidoglycan (supporting polymer of the cell wall) during the period of division and growth, causes lysis of bacteria.

Active against: aerobic gram-positive microorganisms: Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp. and aerobic Gram-negative microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp. Penicillinase-producing strains are resistant to the action of amoxicillin.

Amosin® - zhartylai synthetical penicillinder tobyndagy aser etu aukymy ken bactericidal antibiotic. Bөlinu zhәne өsu kezende peptidoglycan (zhasusha kabyrgasynyn tirek polimeri) synthesis of buzada, bacterium lysisin tudyrady. Aerobic gramon microorganism: Staphylococcus spp. (penicillinase ondiretin shtamdardy kospagand), Streptococcus spp. not aerobic gramteric microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp. katysty belsendi. Penicillinase ondiretin shtamdar amoxicillin aserine tozimdі.

Packaging and release form

Tablets 250 mg, 500 mg. 10 tablets in a blister pack made of PVC film and printed lacquered aluminum foil. 1 blister pack with instructions for medical use in the state and Russian languages are placed in a pack of cardboard.

250 mg, 500 mg tablets. 10 tablets given polyvinylchloride ulbirden zhane baspaly lactalgan aluminum foildan zhasalgan pishindі ұyashyқty қaptamada. 1 pіshіndі ұyashyқty қaptamadan medicina қoldanyluy zhөnіndegі memlekettіk zhane orys tіlderіndegі nұsқaulyқpen bіrge cardboard pәshkege salads.

All infectious diseases are dangerous and are characterized by the ability to provoke a large number of complications even after recovery. The reasons for their development are pathogenic bacteria into the body.

Full treatment will not work without a course of antibiotics. One of effective and well-known drugs is Amosin 500mg.

In contact with

Composition, release forms

The product is available in coated tablets. They are flat-cylindrical, white, with a chamfer and a risk.

Amosin - an antibiotic with a wide range of effects from the penicillin group. Amoxicillin trihydrate in the preparation is the main active ingredient. Also included are additional substances:

calcium stearate;
magnesium stearate;
magnesium hydrosilicate;
potato starch;
povidone.

After taking the Amosin tablet almost completely absorbed in the digestive system. Meal time does not correlate with absorption. At elevated concentrations, the drug is found in blood plasma, in urine, in sputum from the bronchi, in lung tissues, in the organs of the female reproductive system, and in the intestinal mucosa.

Important! At the stage of metabolism, the drug forms inactive metabolites. About 70% of the drug is excreted in the urine in its original form, 20% - through glomerular filtration, 20% - with bile.

Amosin tablets.

Indications for use

The main indications for use are described in the instructions antibacterial drug Amosin. What helps medicine:

Acute infections affecting the upper respiratory tract.
Acute forms of infections affecting the lower parts of the respiratory system - bronchitis or pneumonia.
Infectious pathologies of ENT organs - otitis media, sinusitis, tonsillitis.
Urogenital infections: urethritis, cystitis, gonorrhea, pyelonephritis.
Infections of the digestive system - typhoid fever, dysentery, cholecystitis or salmonellosis.
Meningitis.
Borreliosis.
Sepsis.
Diseases of the skin, soft tissues - erysipelas, impetigo.
Prevention of infection in postoperative wounds.

In children after 7 years, the drug is used for the treatment of influenza and other acute respiratory viral infections.

Amosin - indications for use.

Treatment time and dosage

Instructions for use gives the following recommendations on how to use the drug:

Any form of medication is intended for oral administration.
Capsules are not recommended to crush, open or chew.
Drink the medicine regardless of the meal.
Tablets can be crushed or divided into parts.
Antibiotics should be taken at regular intervals.
The duration of therapy in accordance with the individual characteristics of the disease and the patient's body doctor sets.
Children weighing more than 40 kg and adults are shown 500 mg tablets 3 times a day. Complications require an increase in dosage: 750 - 1000 mg 3 times a day.
Children aged 5 to 10 years are recommended to take Amosin at a dose of 250 mg 3 times a day (half a 500 mg tablet). Average duration therapy is 10 days.

How are special situations treated?

With the development of complications or in non-standard situations the medicine is taken as follows:

With uncomplicated gonorrhea at the stage of exacerbation, 3000 mg is indicated once a day.
In diseases affecting the organs of the gastrointestinal tract or in gynecological bacterial pathologies, 1500-2000 mg is indicated 4 times a day.
For patients with kidney disease changing the frequency of taking pills, but be sure to save doses. The dosage selected by the doctor is taken with an interval of 12 hours.
For prophylactic treatment of a child, only half the dose of an adult is started.
In children special instructions except for strict adherence to the instructions, there is no treatment.
Amosin with angina helps well for the treatment of bacterial forms.

Amosin's reception in special situations.

Dosage for Amosin powder

The powder is used to mix the suspension. To do this, 500 mg of powder is diluted in a glass with 10 ml of chilled boiled water. All stir until a homogeneous liquid. Amosin with angina in this form is easier to take than pills.

Important! For 125 mg of the active ingredient in powder, 2.5 ml of liquid is needed, for 250 mg - 5 ml of liquid, respectively.

The suspension must be consumed after preparation. Dosage Amosin for adults: 2 times a day - 500 mg.

Use in pregnant women and while breastfeeding

During pregnancy Amosin allowed to apply when the expected beneficial effect on the mother's body is higher than the potential harm to the unborn child.

When lactation Amosin is contraindicated. If a course of drug treatment is required, then breastfeeding is stopped.

Contraindications for treatment with Amosin

To contraindications medicinal product include:

hay fever;
allergic form of diathesis;
bronchial asthma;
liver failure;
pathology of the gastrointestinal tract in the patient's medical history;
lactation;
lymphocytic leukemia;
allergies to the composition of the drug;
sensitivity revealed in a patient to other penicillin preparations;
age under three years - for therapy with capsules or tablets.

Carefully and under the supervision of a specialist therapy is carried out during pregnancy, renal failure, with a tendency to bleeding.

Amosin has a number of contraindications for use.

Side effects

The annotation provides a list of what are side effects:

Allergies: reddening of the skin, urticaria, angioedema, runny nose, less often - joint pain, dermatitis.
From the organs digestive systems: dysbacteriosis, disruption of taste buds, nausea with vomiting, diarrhea, liver dysfunction, glossitis, stomatitis, less often - pseudomembranous enterocolitis.
In work central nervous system: overexcitation, persistent anxiety, sleep disturbance, clouding of consciousness, depression, headache, dizziness and convulsions.
In the work of organs urinary system: in rare cases - interstitial nephritis.
In work circulatory systems: leukopenia, anemia.
Others: complicated breathing, increased heart rate.

special instructions

Take the medicine with extreme caution if a person has a tendency to hypersensitivity, patients under 18 years of age. People with impaired liver function it is forbidden to combine antibiotic along with metronidazole.

Due to the increase in the volume of bacterial microflora insensitive to the drug, the development of a super infection may occur, which involves the organization of urgent additional antibiotic therapy.

In case of abnormalities in the functioning of the kidneys the doctor reduces the dosage and increases the time interval between doses of the medicine. During the period of therapy, it is necessary to constantly monitor the functioning of the liver, circulatory system and kidneys. To reduce the risk of complications associated with digestion, the remedy should be drunk with meals.

There are no data on the prohibition of driving during the course of the drug.

Important! With an independent increase in the dose without consulting a specialist, nausea with vomiting, diarrhea, pain in the epigastric zone, and deviations in the water and electrolyte balance develop.

Overdose gastric lavage is carried out and treatment with enterosorbents is prescribed. According to the nature of the symptoms, symptomatic treatment. It would be appropriate to take saline laxatives and implement procedures to normalize and maintain water and electrolyte balance.

Amosin, like other antibiotics, should be taken with caution.

Interaction

Interaction with other drugs:

Laxatives, antibiotics from aminoglycosides, antacids reduce the absorption of amoxicillin.
On the contrary, it increases absorption.
Bactericidal antibacterial medicines together with Amosin produce a double effect.
Bacteriostatic agents block the action of the drug.
Amosin enhances the effect of indirect anticoagulants.
The drug reduces the effect of oral contraceptives.
With simultaneous treatment with Allopurinol, the risks of developing skin rashes increase.
The active substance Amosin - amoxicillin - reduces the clearance and toxic effects on the body of Methotrexate.
Also, the drug enhances the absorption of Digoxin in the body.

Analogues

Amosin's analogs - drugs of the same group with a similar or identical effect. Amosin and

An antibiotic of the group of semi-synthetic penicillins with a wide spectrum of action. It is a 4-hydroxy analogue of ampicillin. It has a bactericidal effect. Active against aerobic Gram-positive bacteria: Staphylococcus spp. (with the exception of penicillinase-producing strains), Streptococcus spp.; aerobic Gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp.

Microorganisms producing penicillinase are resistant to amoxicillin.

In combination with metronidazole, it is active against Helicobacter pylori. Amoxicillin is believed to inhibit the development of Helicobacter pylori resistance to metronidazole.

Cross-resistance exists between amoxicillin and ampicillin.

Range antibacterial action expands with the simultaneous use of amoxicillin and the beta-lactamase inhibitor clavulanic acid. This combination increases the activity of amoxicillin against Bacteroides spp., Legionella spp., Nocardia spp., Pseudomonas (Burkholderia) pseudomallei. However, Pseudomonas aeruginosa, Serratia marcescens and many other Gram-negative bacteria remain resistant.

Pharmacokinetics

When taken orally, amoxicillin is rapidly and completely absorbed from the gastrointestinal tract, is not destroyed in the acidic environment of the stomach. Cmax of amoxicillin in plasma is reached after 1-2 hours. With a 2-fold increase in the dose, the concentration also increases by 2 times. In the presence of food in the stomach does not reduce overall absorption. With intravenous, intramuscular administration and ingestion, similar concentrations of amoxicillin are achieved in the blood.

The binding of amoxicillin to plasma proteins is about 20%.

Widely distributed in tissues and body fluids. High concentrations of amoxicillin in the liver have been reported.

T 1 / 2 from plasma is 1-1.5 hours. About 60% of the dose taken orally is excreted unchanged in the urine by glomerular filtration and tubular secretion; at a dose of 250 mg, the concentration of amoxicillin in the urine is more than 300 mcg / ml. A certain amount of amoxicillin is determined in the feces.

In newborns and the elderly, T 1/2 may be longer.

With renal failure, T 1/2 can be 7-20 hours.

In small amounts, amoxicillin penetrates the BBB during inflammation of the pia mater.

Amoxicillin is removed by hemodialysis.

Release form

Powder for suspension for oral administration, white with a yellowish tint, with a specific odor; prepared suspension of white color with a yellowish tint, with a specific odor.

Excipients: polyvinylpyrrolidone (povidone), dextrose, disodium salt of ethylenediaminetetraacetic acid (Trilon B), dibasic sodium phosphate, sodium glutamate monohydrate, food flavoring, vanillin, sucrose.

1.5 g - single-dose packages (10) - packs of cardboard.

Dosage

Individual. For oral administration, a single dose for adults and children over 10 years old (weighing more than 40 kg) is 250-500 mg, with severe disease - up to 1 g. For children aged 5-10 years, a single dose is 250 mg; at the age of 2 to 5 years - 125 mg; for children under 2 years old daily dose is 20 mg/kg. For adults and children, the interval between doses is 8 hours. In the treatment of acute uncomplicated gonorrhea, 3 g once (in combination with probenecid). In patients with impaired renal function with CC 10-40 ml / min, the interval between doses should be increased to 12 hours; with CC less than 10 ml / min, the interval between doses should be 24 hours.

For parenteral use in adults, intramuscularly - 1 g 2 times / day, intravenously (with normal kidney function) - 2-12 g / day. Children in / m - 50 mg / kg / day, a single dose - 500 mg, the frequency of administration - 2 times / day; in / in - 100-200 mg / kg / day. In patients with impaired renal function, the dose and interval between injections must be adjusted in accordance with the values of CC.

Interaction

Amoxicillin may reduce the effectiveness of oral contraceptives.

With the simultaneous use of amoxicillin with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin), synergism is manifested; with bacteriostatic antibiotics (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonism.

Amoxicillin enhances the effect of indirect anticoagulants by suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index.

Amoxicillin reduces the effect of drugs, during the metabolism of which PABA is formed.

Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs reduce the tubular secretion of amoxicillin, which may be accompanied by an increase in its concentration in blood plasma.

Antacids, glucosamine, laxatives, aminoglycosides slow down and reduce, and ascorbic acid increases the absorption of amoxicillin.

At combined application amoxicillin and clavulanic acid, the pharmacokinetics of both components does not change.

Side effects

Allergic reactions: urticaria, erythema, angioedema, rhinitis, conjunctivitis; rarely - fever, joint pain, eosinophilia; in isolated cases - anaphylactic shock.

Effects associated with chemotherapeutic action: the development of superinfections is possible (especially in patients with chronic diseases or reduced body resistance).

With prolonged use in high doses: dizziness, ataxia, confusion, depression, peripheral neuropathy, convulsions.

Mainly when used in combination with metronidazole: nausea, vomiting, anorexia, diarrhea, constipation, epigastric pain, glossitis, stomatitis; rarely - hepatitis, pseudomembranous colitis, allergic reactions (urticaria, angioedema), interstitial nephritis, hematopoiesis disorders.

Mainly when used in combination with clavulanic acid: cholestatic jaundice, hepatitis; rarely - erythema multiforme, toxic epidermal necrolysis, exfoliative dermatitis.

Indications

For use as monotherapy and in combination with clavulanic acid: infectious and inflammatory diseases caused by susceptible microorganisms, incl. bronchitis, pneumonia, tonsillitis, pyelonephritis, urethritis, gastrointestinal infections, gynecological infections, infectious diseases of the skin and soft tissues, listeriosis, leptospirosis, gonorrhea.

For use in combination with metronidazole: chronic gastritis in the acute phase, peptic ulcer of the stomach and duodenum in the acute phase, associated with Helicobacter pylori.

Contraindications

Infectious mononucleosis, lymphocytic leukemia, severe gastrointestinal infections with diarrhea or vomiting, respiratory viral infections, allergic diathesis, bronchial asthma, hay fever, hypersensitivity to penicillins and / or cephalosporins.

For use in combination with metronidazole: diseases of the nervous system; hematopoietic disorders, lymphocytic leukemia, infectious mononucleosis; hypersensitivity to nitroimidazole derivatives.

For use in combination with clavulanic acid: a history of liver dysfunction and jaundice associated with taking amoxicillin in combination with clavulanic acid.

Application features

Use during pregnancy and lactation

Amoxicillin crosses the placental barrier and is excreted in small amounts in breast milk.

If it is necessary to use amoxicillin during pregnancy, the expected benefit of therapy for the mother and the potential risk to the fetus should be carefully weighed.

Use amoxicillin with caution during lactation (breastfeeding).

Application for violations of liver function

Amoxicillin in combination with metronidazole should not be used in liver disease.

Application for violations of kidney function

In patients with impaired renal function, the dose and interval between injections must be adjusted in accordance with the values of CC.

Use in children

Use in children is possible according to the dosing regimen.

Amoxicillin in combination with metronidazole is not recommended for use in patients under 18 years of age.

special instructions

Use with caution in patients prone to allergic reactions.

Amoxicillin in combination with metronidazole is not recommended for use in patients under 18 years of age; should not be used in liver disease.

On the background combination therapy alcohol is not recommended with metronidazole.

In this article, you can read the instructions for using the drug Amosin. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of the Amosin antibiotic in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Amosin in the presence of existing structural analogues. Use for the treatment of tonsillitis, pneumonia, sinusitis and other infectious diseases in adults, children, as well as during pregnancy and lactation. The composition and interaction of the drug with alcohol.

Amosin- a broad-spectrum antibiotic of a group of semi-synthetic penicillins. Acts bactericidal. It inhibits transpeptidase, disrupts the synthesis of peptidoglycan (the supporting polymer of the cell wall) during division and growth, and causes bacterial lysis. Acid resistant.

Active against aerobic Gram-positive bacteria: Staphylococcus spp. (staphylococcus aureus) (with the exception of strains producing penicillinase), Streptococcus spp. (streptococcus); aerobic Gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Bacillus anthracis, Listeria monocytogenes (Listeria), Helicobacter pylori (Helicobacter), Klebsiella spp. (Klebsiella).

Microorganisms producing penicillinase are resistant to the action of amoxicillin.

The action develops 15-30 minutes after administration and lasts 8 hours.

Compound

Amoxicillin (in the form of trihydrate) + excipients.

Pharmacokinetics

After oral administration, Amosin is rapidly and almost completely (93%) absorbed from the gastrointestinal tract. Eating does not affect the absorption of the drug, is not destroyed in the acidic environment of the stomach. It is found in high concentrations in plasma, sputum, bronchial secretions (poor distribution in purulent bronchial secretions), pleural and peritoneal fluid, urine, contents of skin blisters, lung tissue, intestinal mucosa, female genital organs, prostate gland, middle ear fluid, bones , adipose tissue, gallbladder (with normal liver function), fetal tissues. When the dose is increased by 2 times, the concentration also increases by 2 times. The concentration in bile exceeds the concentration in plasma by 2-4 times. In the amniotic fluid and vessels of the umbilical cord, the concentration of amoxicillin is 25-30% of the plasma level in a pregnant woman. Poorly penetrates the blood-brain barrier (BBB), with inflammation of the meninges (meningitis), the concentration in the cerebrospinal fluid is about 20%. Plasma protein binding - 17%. A small amount is excreted in breast milk. Amoxicillin is partially metabolized to inactive metabolites. Amoxicillin is excreted by 50-70% in the urine unchanged by tubular excretion (80%) and glomerular filtration (20%), with bile - 10-20%.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

respiratory infections (including bronchitis, pneumonia);
infections of ENT organs (including sinusitis, pharyngitis, tonsillitis, acute otitis media);
infections of the genitourinary system (including pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea);
gynecological infections (including endometritis, cervicitis);
infections of the digestive tract (including peritonitis, enterocolitis, typhoid fever, cholangitis, cholecystitis);
infections of the skin and soft tissues (including erysipelas, impetigo, secondarily infected dermatoses);
leptospirosis;
listeriosis;
Lyme disease (borreliosis);
dysentery;
salmonellosis, salmonellosis;
meningitis;
endocarditis (prevention);
sepsis.

Release form

Capsules 250 mg.

Tablets 250 mg and 500 mg.

Powder for suspension for oral administration 125 mg, 250 mg and 500 mg.

Instructions for use and dosage

Adults and children over 10 years old (weighing more than 40 kg) are prescribed 500 mg 3 times a day, in severe cases of the disease - 0.75-1 g 3 times a day.

For children under the age of 5 years, the drug is prescribed in the form of a suspension (ideal children's form of the drug).

For the treatment of acute uncomplicated gonorrhea, the drug is prescribed at a dose of 3 g once; in the treatment of women, repeated administration of the indicated dose is recommended.

In acute infectious diseases of the gastrointestinal tract (paratyphoid, typhoid fever) and biliary tract, with gynecological infectious diseases, adults are prescribed 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

With leptospirosis, adults are prescribed 500-750 mg 4 times a day for 6-12 days.

With salmonella carriage in adults - 1.5-2 g 3 times a day for 2-4 weeks.

Rules for preparing a suspension from a single-dose package

Boiled and cooled water is poured into a clean glass in the amount indicated in the table, then the contents of one package are poured out and mixed until a homogeneous suspension is obtained.

The dose in the package is 125 mg - the required amount of water is 2.5 ml;
dose in a package of 250 mg - the required amount of water is 5 ml;
the dose in the package is 500 mg - the required amount of water is 10 ml.

After taking the glass, rinse with water, dry and store in a dry, clean place.

Side effect

hives;
skin hyperemia;
erythema;
angioedema;
rhinitis;
conjunctivitis;
fever;
pain in the joints;
eosinophilia;
exfoliative dermatitis;
multiform exudative erythema;
Stevens-Johnson syndrome;
reactions similar to serum sickness;
anaphylactic shock;
dysbacteriosis;
taste change;
vomiting, nausea;
diarrhea;
stomatitis;
glossitis;
pseudomembranous enterocolitis;
excitation;
anxiety;
insomnia;
confusion;
behavior change;
depression;
peripheral neuropathy;
headache;
dizziness;
convulsive reactions;
interstitial nephritis;
leukopenia, neutropenia, thrombocytopenic purpura, anemia;
labored breathing;
tachycardia;
vaginal candidiasis;
superinfection (especially in patients with chronic diseases or reduced body resistance).

Contraindications

allergic diathesis;
bronchial asthma, hay fever;
Infectious mononucleosis;
lymphocytic leukemia;
liver failure;
a history of gastrointestinal disease (especially colitis associated with the use of antibiotics);
lactation period (breastfeeding);
hypersensitivity to the components of the drug;
hypersensitivity to other penicillins, cephalosporins, carbapenems;
children's age up to 3 years (for tablets and capsules).

Use during pregnancy and lactation

The use of the drug during pregnancy is possible only in cases where the intended benefit of therapy for the mother outweighs the potential risk to the fetus.

Use during lactation is contraindicated. If necessary, use during lactation should stop breastfeeding.

Use in children

special instructions

When conducting a course of treatment with Amosin, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

Perhaps the development of superinfection due to the growth of microflora insensitive to amoxicillin, which requires a corresponding change in antibiotic therapy.

When treating patients with bacteremia, a bacteriolysis reaction rarely develops (the Jarisch-Herxheimer reaction).

In patients with hypersensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

In the treatment of mild diarrhea against the background of the use of Amosin, the appointment of antidiarrheal drugs that reduce intestinal motility should be avoided; kaolin- or attapulgite-containing antidiarrheals may be used. In severe diarrhea, it is necessary to conduct a differential diagnosis and prescribe appropriate therapy.

Treatment should be continued for another 48-72 hours after the disappearance of clinical signs of the disease.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, additional methods of contraception should be used, if possible.

drug interaction

Antacids, glucosamine, laxatives, food, antibiotics of the aminoglycoside group, while used simultaneously, slow down and reduce the absorption of Amosin; ascorbic acid - increases its absorption.

Amoxicillin, with simultaneous use, increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives, ethinyl estradiol (the risk of intermenstrual bleeding), as well as drugs, during the metabolism of which para-aminobenzoic acid is formed.

The joint use of the drug Amosin with alcohol is prohibited (the hepatotoxic effect of ethanol is enhanced).

With the simultaneous use of Amosin with allopurinol, the risk of developing a skin rash increases.

Amoxicillin with simultaneous use reduces clearance and increases the toxicity of methotrexate.

Amoxicillin with simultaneous use enhances the absorption of digoxin.

Analogues of the drug Amosin

Structural analogues for the active substance:

Amoxisar;
Amoxicillin;
Amoxicillin trihydrate;
Gonoform;
Grunamox;
Danemox;
Ospamox;
Flemoxin Solutab;
Hyconcil;
Ecoball.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Infectious diseases are known to be quite dangerous and insidious. And the most unpleasant thing is the complications that they can cause. The causes of infectious pathologies are hidden in the penetration of harmful bacteria into the body. The patient can be cured only with antibiotics. One of these drugs is the drug "Amosin" 500 mg. Instructions for use will allow you to study this tool in more detail.

Description of the drug

So, let's consider how the drug "Amosin" is positioned by the instructions for use (indications, release forms). The drug is a Distinctive characteristic of the drug - a wide range of effects and a high bactericidal effect.

The antibiotic is able to fight a variety of gram-negative and gram-positive microorganisms:

streptococci;
staphylococci;
Klebsiella;
salmonella;
helicobacter pylori;
gonococci;
listeria;
causative agents of meningitis, anthrax.

The drug "Amosin" inhibits the synthesis of substances that are the basis of cell membranes. As a result, their integrity is violated. This leads to the death of bacteria.

As evidenced by the instructions for use attached to the drug "Amosin" (500 mg), the drug has an effect on the body within 15-30 minutes after its use. The beneficial effect lasts for 8 hours.

The drug, getting into the body, is quickly and almost completely absorbed in the gastrointestinal tract. The active substance of the drug enters not only into the blood. It penetrates the mucous membranes bone tissue, organs, fluids.

Release form

The main active ingredient of the drug is amoxicillin. It is this that has a healing effect on the body. So says the instructions attached to the drug "Amosin".

The release form of the drug allows you to choose the right medicine for any category of patients.

After all, the drug is produced in the form:

Tablets. By appearance These are pills of a white shade, flat-cylindrical. They may contain the active substance in the amount of: 250 mg, 500 mg.
Capsule. These are gelatin containers, white. They contain white granules. The dosage of the active substance is 250 mg.
powder. It is intended for self-manufacturing suspensions. The powder has a slightly yellowish tint. Has a specific smell. The prepared suspension retains its aroma and yellowish tint. The drug is produced in several dosages: 125, 250, 500 mg.

Indications for use

The drug is recommended for use in various bacterial infections that are provoked by sensitive microflora. The drug "Amosin" 500 mg instructions for use advises using for multiple infections of the respiratory tract, skin, genitourinary system.

The main indications for the appointment of the drug are:

diseases respiratory organs(bronchitis, pneumonia);
pathology of ENT organs (tonsillitis, sinusitis, pharyngitis, otitis media);
ailments of the genitourinary system (pyelonephritis, urethritis, gonorrhea, pyelitis, cystitis);
gynecological infections (endometritis, cervicitis);
diseases of the digestive tract (peritonitis, enterocolitis, cholangitis, cholecystitis);
pathologies of soft tissues and skin (erysipelas, impetigo, dermatoses);
listeriosis;
leptospirosis;
borreliosis (Lyme disease);
dysentery;
meningitis;
salmonellosis;
endocarditis (for preventive purposes);
sepsis.

How does the instructions for use advise taking the drug "Amosin" (in tablets and capsules)?

The summary of the medication gives the following recommendations:

In any form intended for oral administration"Amosin".
Capsules instructions for use advises not to chew or crush. They should be consumed before or after meals.
"Amosin 500" (tablets) instructions for use recommends taking regardless of food. Pills are allowed to be crushed, divided into parts.
Take the medicine at regular intervals.
The recommended course of therapy with this remedy is determined only by the doctor.
Adults and children from 10 years of age, if the body weight of the latter is above 40 kg, is prescribed 500 mg of the drug 3 times a day.
If the pathology is severe, the doctor may recommend a higher dose of the drug. In this case, the patient is prescribed 3 times a day to take 750-1000 mg.
How does the instruction for use recommend taking the medicine "Amosin" (in tablets for children from 5 to 10 years old)? Such patients are prescribed 3 times a day to use 250 mg.
On average, the duration of treatment is 5-12 days.

Specific treatment regimens

The dosage of the drug may vary depending on the pathology. It is necessary to take into account the condition of the patient, and age, and weight. That is why it is important for a specialist to choose a treatment regimen. Consider how it recommends taking the drug "Amosin" instructions for use. In tablets or capsules, it doesn't matter.

The following diagrams are shown:

In the acute stage of gonorrhea, the patient is prescribed a single dose of 3000 mg of the drug. For women, repeated administration of the drug at the same dosage may be recommended.
For the treatment of gastrointestinal diseases and gynecological ailments, it is recommended to use 1500-2000 mg 3 times a day. Another treatment regimen may be prescribed. In this case, the patient should take 1000-1500 mg 4 times a day.
Leptospirosis is cured by taking 500-750 mg of the drug. The multiplicity of the use of the drug - 4 times a day. Assign such treatment for 6-12 days.
If salmonellosis is detected, then it is recommended to use 1500-2000 mg 3 times a day. According to this scheme, the drug is used for 2-4 weeks.
For the prevention of endocarditis, as well as in the case of surgical operations, the patient is prescribed 1 hour before the intervention, taking the drug at a dose of 3000-4000 mg.
Re-administration of the drug is possible only after 8-9 hours after the first dose.
For people who have impaired kidney function, the doctor will reduce the frequency of taking the medicine. In this case, the dosage of the drug is saved.
The maximum dose for patients with anuria is 2000 mg.

Features of taking the powder

The powder is used as follows:

The drug is intended, as mentioned above, for the manufacture of a suspension.
To prepare the solution, it is necessary to pour boiled water (chilled) in an amount of 10 ml into a glass. The contents of the sachet (500 mg of powder) are poured into it. Stir until a homogeneous suspension is formed. If you are using a preparation containing 125 mg of active ingredient, then 2.5 ml of liquid will be needed. For 250 mg of water powder take 5 ml.
The suspension is taken immediately after its preparation.
If you are using a drug packaged in vials or jars, then you need to pour the contents with water in an amount of 62 ml. Shake the container vigorously until the medication is completely dissolved. The prepared suspension contains 1 ml of 50 mg of amoxicillin.
Adults are recommended to take 500 mg of the drug 3 times a day. A single dosage corresponds to 1 sachet of powder.

Treatment of babies

The annotation of the medication contains the following rules:

Patients over 10 years old, weighing more than 40 kg, are recommended to use the medicine in the same way as adults. It is prescribed 3 times a day to use 500 mg of the drug.
For children from 5 to 10 years old, it is better to use tablets containing 250 mg of amoxicillin or powder in the same dosage. Such children are recommended to take 1 pill (250 mg) 3 times a day or dilute 1 sachet of medicine.
Babies 2-5 years old are prescribed to take 125 mg three times a day.
For crumbs up to 2 years, the dosage is calculated taking into account body weight - 20 mg / kg.

Side effects

During treatment with the drug, unwanted reactions may occur. This is warned by the instructions for use attached to the drug "Amosin".

Tablets (500mg), capsules and powder can provoke problems from a number of systems. This:

Gastrointestinal tract and Against the background of therapy may appear: dysbacteriosis, diarrhea, vomiting, taste disturbance. Sometimes there is the occurrence of glossitis, stomatitis, nausea. In some cases, there is an increase in the activity of liver enzymes.
The blood system. Patients may experience the development of neutropenia. Sometimes the drug provokes leukopenia, anemia,
Nervous system. Patients may complain of arousal, increased anxiety, disturbed sleep. Some patients experience confusion, ataxia, depression, and behavioral changes. Headache, peripheral neuropathy, convulsions, dizziness may develop.
Allergic reactions. Therapy with this agent sometimes leads to the appearance of itching, rash, hyperemia of the integument, urticaria, erythema. Some patients may develop allergic conjunctivitis, rhinitis. There are cases when the drug caused anaphylactic shock and reactions resembling

In addition to the above negative signs, the following may appear:

labored breathing;
arthralgia;
interstitial nephritis;
candidal vaginitis;
tachycardia;
superinfection.

If you have these symptoms, contact your doctor. He will cancel the drug and select another remedy for treatment.

Contraindications

The medication should not be taken for such ailments as:

allergic diathesis;
hay fever;
lymphocytic leukemia;
lactation period;
ailments of the gastrointestinal tract in history;
Infectious mononucleosis;
liver failure;
hypersensitivity;
bronchial asthma;
children's age, under 3 years (this applies to tablets, capsules).

In some patients, the question sometimes arises as to whether it is possible to combine alcohol-containing drinks with Amosin (500 mg) medication. Instructions for use and alcohol is important points that are worth paying attention to. The use of alcoholic beverages during treatment with the drug is prohibited.

In addition, you should limit activities associated with a high concentration of attention.

Very carefully, the medication can be prescribed to pregnant women, patients with renal insufficiency. Patients who have a history of bleeding require special attention.

Overdose symptoms

If the patient takes high doses of the drug, the following symptoms may develop:

diarrhea;
vomiting, nausea;
disturbed water and electrolyte balance;
abdominal pain.

There is no specific antidote for this drug. Therefore, in case of overdose, symptomatic therapy is undertaken. Initially, the patient is washed out the stomach. The patient is shown the use of enterosorbent drugs.

It is important to protect the body from water and electrolyte imbalance. For this, the patient is recommended measures aimed at maintaining balance in the body. Salt laxatives are also prescribed.

To lower the plasma concentration of amoxicillin, your doctor may recommend hemodialysis.

Drug analogues

You can replace the original remedy with other, no less effective, medicines. However, remember that only your doctor can prescribe or stop antibiotics.

Analogue drugs:

"Flemoxin Solutab";
"Ecoball";
"Amoxicillin";
"Amoxisar";
"Hikoncil";
"Gonoform";
"Ospamox";
"Danemoks";
"Grunamox".

Medication opinions

Above, it is described how the drug "Amosin" (500 mg) is positioned for instructions for use. Reviews of people who took the drug are of great interest. Therefore, let us consider what the patients say about the remedy.

Opinions about the drug are quite ambivalent. Some people claim that the medicine was prescribed to them in severe stages of ailments, such as bronchitis, pneumonia, otitis media with complications. Such patients testify that the drug "Amosin" helped them to recover from serious pathologies. However, they claim that the improvement occurred in just a couple of days. Having drunk the medication according to the scheme prescribed by the doctor, they completely restored the body. Wherein side effects they did not have.

A slightly different opinion is shared by another category of people. They claim that they started taking the antibiotic without a doctor's prescription. They managed to achieve a therapeutic effect - the disease receded. But after therapy there were some consequences. Most patients complain about the appearance of dysbacteriosis. This category of people had to deal with the negative consequences of self-treatment for a long time.

And of course, there are reviews indicating that taking the drug in the very first days provoked the development of side effects. Such people do not undertake to assert the effectiveness of the remedy, but they emphasize that the medication can become a source of rather unpleasant symptoms.