Betadine syrup instructions for use. Betadine solution

It is known that the markets for any products that people need are always and constantly developing and offering consumers more and more new products. Pharmacology was no exception, which for many centuries of its existence has used dried bats, and mercury, and honey, and morning dew, and powdered diamonds or sapphires, and tears of infants.

However, today's pharmacology is a powerful science-intensive production, huge scientific institutes and laboratories equipped with the latest science and technology, thousands of studies on a variety of topics. Studies are also being carried out on the popularity of certain medicines and their demand. How do people feel about different drugs?

According to medical statistics, a certain part of consumers trust only old and time-tested products, even if modern science for a long time and quite reasonably offers something new and more effective. Many consumers choose only those that are cheaper from a range of suitable medicines, and only buy something more expensive when there is simply no alternative.

There are also consumers who trust only expensive branded drugs from the world's most famous manufacturers, believing that good medicine cannot be cheap: research, raw materials, production, testing and other necessary procedures are in any case money, and a lot of money.

So where will low prices for quality medicines come from? But there are also drugs that suit both supporters of everything proven and adherents of only the new, especially since the cost of such drugs is precisely the “golden mean” that is often considered unattainable. In this case, we will talk about Betadine. And, as you know, Betadine. Is this really so and what is the secret of this drug?

A little more about Betadine as a brand name for Povidone-iodine

Betadine has been on the pharmaceutical market for a long time. The manufacturer of this pharmaceutical preparation is the Hungarian pharmaceutical company Egis (“EGIS”), which has long occupied a very prominent place in the pharmaceutical market of Central and Eastern Europe and is quite rightly considered one of the leading companies.

The active ingredient in Betadine is Povidone-iodine (Povidonum-iodum), that is, a compound of molecular iodine and 1-ethenylpyrrolidin-2-one.

Betadine, like any medicinal substance based on Povidone-iodine, belongs to the pharmaceutical group of antiseptics and disinfectants(drugs).

Povidone-iodine has more than one trade name, that is, it can be called not only "Betadine", - the same drug can enter the pharmaceutical trade network under the names "Aquazan", "Vokadin", "Iodovidon", "Iodosept", "Iodoxide ”, “Iodoflex”, “Octasept”, and also have other trade names.

What is Povidone Iodine? The Latin name for this remedy is Povidonum-iodum, and the English name that occurs is Povidone-iodine. However, the name does not have any effect on the properties of this drug, which is an antiseptic ( antiseptic) for topical use.

As the name implies (povidone-iodine), the most important component of this antiseptic is iodine. However, in this case, the traditional and familiar to all iodine combines with polyvinylpyrrolidone (PVP), which binds it, which is also called iodoform, forming a special complex. Interestingly, the concentration of active iodine in the Povidone-iodine complex can be different - from 0.1% to 1%.

It will probably be interesting to know that Povidone-iodine is a yellow-brown amorphous powder (the color is due to the action of iodine). Most often, this powder has no smell or a very slight specific smell of iodine is felt. This powder is hygroscopic, that is, it is able to absorb moisture from the air, dissolves well, but slowly in water, and can also dissolve in ethanol (95%). However, Povidone-iodine does not dissolve in either ether or chloroform. It is known that Povidone-iodine powder can change under the influence of light, so it can only be stored in a dark place.

Attention! Povidone-iodine, in addition to its antiseptic action, is also known for its disinfectant, bactericidal, antifungal, as well as antiprotozoal and antiviral properties.

It is known that the antimicrobial properties of Povidone-iodine (regardless of the trade name of the drug) are based on the fact that iodine is able to damage the cell walls of pathogenic, that is, pathogenic, microorganisms.

Coming into contact with the biological environment (biological material), iodine is released from the formed complex with polyvinylpyrrolidone and forms iodamines, attaching to the proteins of bacterial cells, then iodamines coagulate (small particles stick together into larger flakes, which destroys the structure of the substance), which causes death and destruction of cells of hostile microorganisms.

Attention! It is very important that Povidone-iodine (regardless of the trade name of the drug) acts quickly (has a bactericidal effect) on both gram-positive and gram-negative bacteria. It is very important that Povidone-iodine is able to have an effect on Mycobacterium tuberculosis (tuberculosis bacteria), however, according to some reports, Mycobacterium tuberculosis develops resistance to Povidone-iodine and stops responding to the drug; Povidone-iodine is also able to act on viruses, fungi and protozoa .

As a result of many studies, it was found that Povidone-iodine preparations, including Betadine, act on all harmful microorganisms for a longer time than traditional alcoholic iodine solution.

Dosage forms of Povidone-iodine

In addition to Betadine vaginal suppositories, Povidone-iodine also exists in other dosage forms.

Quite popular is the drug "Octasept" (Povidone-iodine), which is an aerosol agent for topical use.

On the basis of Povidone-iodine, ointments (10%) for external use and solutions (10%) are also made for external use with an antiseptic purpose. Interestingly, the pharmaceutical industry produces concentrates based on Povidone-iodine, from which a solution for external use should then be prepared.

A foaming solution based on Povidone-iodine can also be applied externally.

Very popular "Iodovidon" - an alcohol solution intended for external use.

However, when it comes to Betadine as the perfect guard women's health, then vaginal suppositories (200 mg) are meant. It is vaginal suppositories that are used in gynecological practice for the treatment of candidiasis (fungal infection); trichomoniasis, which is very difficult to treat, since trichomonas can take the form of cysts; nonspecific vaginitis of various etiologies.

Application of Betadine

As you know, Betadine is included in the pharmacological group of antimicrobial and antiseptic agents, and its positive effect is based on the activity of a complex compound of the familiar iodine and polyvinylpyrrolidone.

The researchers explain the action of Betadine in this way: the active iodine ion, coming into contact with the epithelium, is released from the formed complex and interacts with groups of amino acids (amino acid groups) of proteins that are contained in the cells of microorganisms, resulting in the formation of iodamines.

Attention! The mechanism of action of the drug Betadine (Povidone-iodine) excludes the possibility of resistance (addictive effect) to this drug, even in the case of long-term use.

There is a pronounced bactericidal effect of Betadine, as well as its antifungal, antiviral and antiprotozoal activity (sensitivity of gram-negative and gram-positive bacteria is noted).

Researchers and clinicians note that Betadine (like other povidone-iodine preparations) lasts longer when compared to any inorganic iodine preparation. The therapeutic effect lasts until the colored layer completely disappears from the place of application (without a trace). It is also noted that the more intensely the drug stains the surface of the skin, the more effective its effect.

It is also noted that Betatin has a very weak local irritant effect on the skin and / or mucous membranes.

Betadine is available in two dosage forms - a 10% solution and vaginal suppositories.

Application of Betadine in the form of a solution of 10%

Betadine solution is used in many branches of medicine, including surgery, dentistry, combustiology, which deals with severe and complex burn lesions and pathological conditions associated with such burn lesions, as well as methods for optimal and adequate treatment of such conditions; in transplantology, ophthalmology, traumatology and gynecology.

In addition, Betadine solution has been successfully used for effective prevention a wide variety of superinfections that can occur with the use of antibacterial and / or hormonal ointments in dermatological practice.

If any surgical intervention is necessary, Betadine is used for high-quality preparation of the surgical field.

When carrying out almost all transvaginal diagnostic procedures and during surgical interventions - for preoperative and postoperative processing.

Betadine solution is considered indispensable in preparing the patient for invasive procedures, that is, for procedures that involve violation of the integrity of tissues - skin and mucous membranes are treated with betadine solution before procedures such as biopsy, punctures, injections and other invasive procedures.

In the event of wound infections, the use of Betadine solution is also very effective and efficient.

Betadine solution is used to disinfect skin and tissue areas around installed drainage systems, catheters and / or probes.

Betadine in the form of a solution is used in dermatology for the treatment of infectious diseases of the skin, if such infection provoked (caused) by microorganisms that are sensitive to this drug.

Also, Betadine solution is used to disinfect the birth canal during natural (physiological) childbirth.

Betadine solution is considered an effective remedy, if necessary, to treat any burn injuries, trophic ulcers, as well as bedsores and pyoderma.

The use of Betadine in the form of vaginal suppositories

When it comes to Betadine as a tool that is simply indispensable on guard of women's health, they most often mean not even labor and the use of Betadine in preparation for childbirth, but the use of vaginal suppositories, which are often called simply vaginal suppositories. Although it should be noted that the undiluted Betadine solution is successfully used in many gynecological surgical (surgical) interventions, which include such common surgical interventions as termination of an unwanted pregnancy (abortion), coagulation (cauterization) of cervical erosion, introduction into the uterine cavity IUD (intrauterine device), removal of polyps found on the internal female genital organs, as well as other surgical interventions.

As for the use of Betadine suppositories (vaginal suppositories), they are used in several cases.

First of all, betadine suppositories are used to treat vaginitis of various etiologies, including those provoked by a nonspecific infection or a mixed infection.

Sufficiently high efficiency was demonstrated by Betadine vaginal suppositories in the treatment of fungal infections, that is, candidiasis. The particular effectiveness of the use of Betadine suppositories is noted after antibiotic therapy and the use of steroid drugs.

Betadine vaginal suppositories are successfully used in the complex therapy of such a difficult disease to treat as trichomoniasis.

In order for Betadine vaginal suppositories to be used as effectively as possible, several circumstances should be taken into account and not overlooked.

First of all, the Betadine suppository should be removed from the shell before use and moistened with clean water (preferably boiled).

The moistened suppository should be inserted into the vagina, and the suppository should be inserted as deeply as possible.

If chronic vaginitis needs to be treated, then the course of treatment is two weeks (14 days), but sometimes it can be extended for another week (according to the results clinical analyzes and medical examination). In chronic vaginitis, one suppository per day is used.

The advantage of using Betadine vaginal suppositories is that the treatment does not depend on the phase of the menstrual cycle.

Attention! When treating with Betadine vaginal suppositories, the use of sanitary napkins is recommended, as a brownish discharge will appear from the vagina.

Possible side effects when using Betadine

Almost any drug can cause side effects (side effects). When using Betadine, both local and generalized adverse reactions are possible:

to the local side effects Betadine include redness, itching at the site of application, the appearance of iodine acne and contact dermatitis.
Such side effects do not require special treatment - just stop the drug.
More severe side effects (the so-called generalized) may occur with prolonged use of the drug or when it is used on significant (vast, large areas) areas of the affected skin. Severe adverse reactions to the use of Betadine drugs include five serious conditions that require immediate medical attention and serious medical measures to eliminate such conditions.
First of all, when using Betadine (however, as with the use of any drug), an anaphylactic reaction and anaphylactic shock may occur.
Considering that Betadine is an iodine preparation, as a result of its use, iodine-induced hyperthyroidism, that is, a disease thyroid gland.
A very serious, but, fortunately, very infrequent, side reaction with the use of Betadine is problems with the functioning of the kidneys and a violation of their function.
In addition, the use of betadine can cause such a generalized side reaction, as a violation of normal blood formation, that is, disorders of the blood formation system, such as osmolarity disorders, hypernatremia or neutropenia.
In severe cases, the use of Betadine, like any other iodine preparations, can cause the development of metabolic acidosis.

Attention! When any side effects when using Betadine, the drug is immediately canceled, and if generalized side effects appear, serious treatment is carried out. It is very important that if any unusual or incomprehensible symptoms appear, contact your doctor immediately.

Contraindications for the use of Betadine and any other iodine preparations

No matter how harmless iodine and its preparations may seem, however, like any other medicines, they have their contraindications.

First of all, a contraindication is hypersensitivity (immunity) to iodine preparations.
The next very serious contraindication is thyroid diseases, including adenoma of this organ and hyperthyroidism.
A contraindication for the use of iodine preparations, including Betadine, is heart failure.
The use of iodine preparations, including Betadine, can be dangerous, and therefore contraindicated, in case of renal or hepatic insufficiency.
Betadine, like any other iodine preparations, should not be used during childbearing (pregnancy) and breastfeeding (lactation), since iodine metabolites (decomposition products) can cross the placenta and provoke hyperthyroidism in the unborn child.
Also, iodine preparations should not be used in children under one year old.
Betadine is contraindicated before and after radioactive iodine therapy, as well as in some other cases.

Attention! Betadine, like other drugs s Povidone-iodine, can not be used simultaneously with other antiseptics, for example with a drug silver ami, peroxide yu hydrogen, chlorhexidine ohm and others. Preparations Povidone-iodine but not can appoint be simultaneously with any lithium preparations , and when used simultaneously with mercury preparations, alkaline mercury iodide may form.

It is very important to avoid any overdose of Betadine, as well as any other Povidone-iodine preparations, since the consequences of such overdoses are completely unpredictable - from increased salivation to collapse and coma.

conclusions

Betadine- an ideal guardian of women's health? Is it so? Of course, the iodine-based drug helped out many and will come to the rescue more than once in the future. But, like any drug, betadine requires an attentive attitude: no self-prescription, medical supervision, attention to contraindications, caution and caution again!

It seems to be nothing complicated and dangerous - almost like ordinary iodine. However, we should not forget that everything that heals can also become a dangerous poison. Yes, Betadine will get rid of many extremely unpleasant problems, although these problems are not fatal.

But if you treat it medicine without due care, troubles will not keep you waiting. And it is in our power to do everything so that Betadine remains only a guardian of health and never turns into a source of increased danger.

Indications for use:
Betadine ointment:
Prevention of infection in case of skin trauma (minor abrasions and cuts, minor surgical interventions and minor burns);
treatment of infected trophic ulcers or bedsores;
treatment of bacterial, fungal and mixed skin infections.

Betadine solution:
For disinfection of hands, antiseptic treatment of the surgical field (skin or mucous membranes) before obstetric, gynecological, surgical operations and procedures; catheterization Bladder taking biopsies, injections, punctures;
antiseptic treatment of the burn surface and wounds;
as first aid in case of contamination of the skin or mucous membranes with biological or other infectious material;
surgical or hygienic hand disinfection.

Betadine suppositories:
Acute and chronic infections of the vagina (vaginitis): mixed genesis; non-specific (bacterial vaginosis, etc.) and specific genesis (trichomonas infection, genital herpes, etc.);
trichomoniasis (comprising combination therapy using system products);
treatment before or after interventions in transvaginal surgical operations, also in diagnostic and obstetric procedures;
infections of the vagina of fungal etiology (including those caused by Candida albicans), which are provoked by treatment with steroid and antibacterial drugs.

Pharmachologic effect:
Betadine is an antiseptic. Due to the inclusion of iodine, it has a wide spectrum of action against bacteria, protozoa, fungi and some viruses. It has a bactericidal effect with the gradual release of iodine from the product after contact with mucous membranes or skin. The mechanism of action is the interaction of iodine with oxidizable groups of amino acids that are part of the structural proteins and enzymes of microorganisms, as a result of which they are subsequently destroyed or inactivated. The effect of the product begins in the first 15-30 seconds after application, and the complete death of most microbial cells (under in vitro conditions) is observed in less than 60 seconds. Due to interaction with cells, Betadine iodine discolors, therefore, the weakening of the color of the product after contact with the skin, affected surface or mucous membranes can be an indicator of its effectiveness.

Due to the polymer of polyvinylpyrrolidone, the local irritating effect of iodine, characteristic of alcohol solutions, is lost. Therefore, patients tolerate the local effects of the product well. To date, no cases of resistance (including secondary resistance) of any microorganisms, fungi, viruses or protozoa to iodine have been found, even in case of long-term use, due to the peculiarities of the mechanism of action.

With prolonged local use of Betadine, significant absorption of iodine is possible, especially when treating mucous membranes, burn surfaces, and extensive wound defects. Usually, with all this, an increase in the concentration of iodine in the blood is recorded, which returns to the baseline after 1-2 weeks after the use of Betadine. Since the molecular weight of povidone-iodine is in the range of 35,000-50,000 D, renal excretion and absorption of the active substance is delayed. Eliminated mainly by the kidneys. The elimination half-life after insertion into the vagina is approximately 48 hours. The volume of distribution is approximately 38% of body weight. The average level of inorganic iodine in blood plasma is 0.01–0.5 µg/dL, total - 3.8–6.0 µg/dL.

Betadine route of administration and dosage:
Betadine ointment
Used locally. In the treatment of infectious lesions: apply 1-2 times a day for 2 weeks.
For prevention in case of contamination: apply as long as necessary, 1 time in 3 days. The surface must be clean and dry before application. The ointment is applied in a thin layer. After that, an aseptic bandage can be applied to the skin.

Betadine solution
Betadine solution is used externally in undiluted or diluted form. Cannot be used to dilute the solution hot water, however, short heating to the level of body temperature is allowed. Undiluted Betadine solution is used to treat the surgical field and hands before surgery, injections or punctures, bladder catheterization.

For hygienic disinfection of hand skin: 3 ml of undiluted Betadine solution 2 times, each 3 ml portion of the product being left on the skin for 30 seconds.
For surgical hand disinfection: 5 ml of undiluted Betadine solution 2 times, with each 5 ml portion of the product left in contact with the skin for 5 minutes.
For skin disinfection: after lubrication with undiluted Betadine solution, the product must dry for the full effect.

Solutions can be used 2-3 times a day.
According to the same indications for use, Betadine solution is used after dilution tap water. When treating burns and wounds, surgical interventions for dilution use Ringer's solution or isotonic (0.9%) sodium chloride solution. Betadine must be dissolved immediately before use.

The following dilutions are recommended:
for a wet compress - 100-200 ml of Betadine per 1 liter of solvent (1:5 - 1:10);
for sitz or local baths: 40 ml of Betadine per 1 liter of solvent (1:25);
for preoperative bath: 10 ml of Betadine per 1 liter of solvent (1:100);
for a hygienic bath: 10 ml of Betadine per 10 liters of solvent (1:1000);
for douching, irrigation of the peritoneal region, urological irrigation, before the introduction of an intrauterine contraceptive - 4 ml of Betadine per 1 liter of solvent (1:25);
for irrigation in postoperative or chronically current wounds: 5-50 ml of Betadine per 100 ml of solvent (1:20; 1:2);
for irrigation of the oral cavity, traumatological or orthopedic irrigation: 10 ml of Betadine per 1 liter of solvent (1:100).

Betadine suppositories
Before the introduction, the suppository is released from the contour shell and slightly wetted. During treatment, it is advisable to use sanitary pads. Enter 1 suppository at bedtime deep into the vagina. Perhaps the introduction and during menstruation. The dosage can be increased (2 suppositories every day), and the course of treatment can be continued in case of incomplete effectiveness of the product. The course of treatment is approximately 7 days (depending on the desired effect).

Betadine contraindications:
Hyperthyroidism;
dysfunction or adenoma of the thyroid gland (endemic goiter, colloid nodular goiter or Hashimoto's thyroiditis);
the period before or after any procedures (for example, scintigraphy) with the introduction of radioactive iodine;
dermatitis herpetiformis Dühring;
During pregnancy and breastfeeding;
kidney failure;
age up to 1 year;
individual hypersensitivity to iodine or other components of Betadine.

Betadine side effects:
Allergic reactions on the skin and mucous membranes (hyperemia, itching, rash) are possible. Predisposed patients may develop iodine-induced hyperthyroidism. Rarely - acute generalized reactions with suffocation and / or hypotension (anaphylactic reactions). Possible dermatitis with the development of psoriasis-like elements. Application of the product to large areas in case of severe burns or wounds can provoke negative reactions from electrolyte metabolism (increase in the level of sodium in the blood serum), metabolic acidosis, changes in osmolarity, impaired renal function (including the possibility of acute renal failure).

Pregnancy:
The use of Betadine during breastfeeding or pregnancy is recommended only in the presence of absolute indications and only in small doses. The absorbed iodine penetrates into breast milk and through the transplacental barrier. During lactation, the iodine content in breast milk more than the serum level, so when using Betadine in pregnant women breast-feeding stop. The use of povidone-iodine by pregnant and lactating mothers can provoke transient hyperthyroidism in the newborn (fetus). In this case, it is recommended to examine the baby for thyroid function.

Overdose:
Symptoms of acute iodine intoxication: increased salivation, metallic taste in the mouth, pain in the throat or mouth; heartburn, swelling and eye irritation. Gastrointestinal disorders, skin reactions, anuria or deterioration in kidney function, laryngeal edema with signs of secondary asphyxia, circulatory failure, hypernatremia, metabolic acidosis, pulmonary edema are possible.

Treatment: symptomatic or supportive agents under the control of thyroid and kidney function, electrolyte balance.
In case of intoxication with iodine, accidentally taken orally, an urgent gastric lavage (sodium thiosulfate 5% solution), the appointment of food rich in protein and starch (for example, a solution of starch in milk) is necessary. If necessary, the introduction of a solution of sodium thiosulfate (10 ml of 10%) is administered intravenously at intervals of 3 hours. Against the background of treatment, a thorough study of the functions of the thyroid gland is shown in order to timely diagnose hyperthyroidism, which can be caused by povidlon-iodine.

Use with other medicinal products:
The combination of hydrogen peroxide and Betadine for wound treatment is not recommended, as this negatively affects the effectiveness of both antiseptics. Also, you can not use a combination of Betadine with products that include tauloridine, enzymes or silver. When mixed with mercury-containing products, alkaline mercury iodide is formed, so this combination is not allowed. The low effectiveness of the product can be compensated by increasing the dosage, since povidone-iodine reacts with organic unsaturated complexes and proteins. It is not recommended to prescribe Betadine to patients taking lithium-containing drugs. Avoid prolonged use of the product on large areas of the skin and mucous membranes.

Release form:
Betadine ointment: 10% ointment in tubes of 20 g.
Betadine solution: solution for external use 10% in 30 vials; 120; 1000 ml.
Betadine suppositories for vaginal use: 200 mg each, in a blister pack 7; 14 suppositories.

Storage conditions:
Betadine ointment: at a temperature of 25 ° C in a dark place.
Betadine solution: at a temperature of 5 to 15 ° C in a dark, dry place.
Betadine suppositories: at a temperature of 5 to 15 ° C in a dark place.

Betadine composition:
Betadine ointment
Active substance: povidone-iodine 10% (corresponding to active free iodine - 10 mg per 1 g).
Inactive substances: macrogol, sodium bicarbonate, purified water.

Betadine solution
Active substance (in 1 ml): povidone-iodine 100 mg (which corresponds to active free iodine - 10 mg in 1 ml).
Inactive substances: nonoxynol, glycerin, sodium hydroxide, citric disodium phosphate, anhydrous acid, purified water.

Betadine suppositories
Active substance: povidone-iodine 200 mg.
Inactive substances: macrogol 1000.

Additionally:
The effectiveness of the solution is evidenced by a dark brown color after application: a decrease in brightness indicates a decrease in the antimicrobial activity of the agent. Under the influence of temperature over 40 ° C or light, povidone-iodine is destroyed. Antimicrobial activity is manifested at a pH of the Betadine solution of 2-7. Against the background of the use of povidone-iodine, a decrease in the absorption of the iodine molecule by the thyroid gland can be observed - this affects the results of some additional studies (determination of protein-bound iodine, thyroid scintigraphy and other diagnostic methods using radioactive iodine). If the above procedures are planned for the patient, then the use of povidone-iodine is stopped 1–4 weeks in advance. The oxidizing action of Betadine causes corrosion of metals. Synthetic and plastic materials are not sensitive to povidone-iodine. Occasionally, contact with certain materials may cause discoloration of the solution, which usually recovers quickly. Stains from povidone-iodine are easily removed from textiles and other materials by the action of warm soapy water. If stains are difficult to remove, they are treated with a solution of sodium thiosulfate or ammonia. The use of Betadine solution inside is not allowed.

Under conditions of skin treatment before surgery, it is necessary to ensure that the solution does not flow under the patient's body - otherwise skin irritation is possible. With prolonged (more than 2 weeks) use of the product over large areas (approximately 10% of the body surface), the development of hyperthyroidism cannot be ruled out, especially in elderly patients with latent thyroid dysfunction. In this category of patients, the use of the solution should be evaluated in terms of comparing the possible risk and the expected benefit. When deciding on the appointment of the product, it is necessary to monitor the functions of the thyroid gland for timely diagnosis. early signs hyperthyroidism. The control is carried out against the background of the use of the agent, as well as during a 3-month interval later in the subsequent use. Prolonged use of Betadine may cause irritation, in very rare cases, severe skin reactions. If symptoms of allergy or irritation appear, stop using the product.

Patients with impaired thyroid function should limit the surface to be treated or reduce the duration of contact of povidone-iodine with the skin (for solution or ointment). In the case of the development of signs of hyperthyroidism against the background of the use of Betadine, an examination of the thyroid gland is necessary. In newborns, as well as young children, it is necessary to avoid the use of iodine in large doses, since their skin has a high permeability threshold (there is a higher risk of hyperthyroidism or hypersensitivity to povidone-iodine). With caution, the drug is prescribed to patients with insufficiency of kidney function or taking lithium-containing drugs, especially if regular use of Betadine is necessary.

Attention!
Before using the medication "Betadine" you need to consult a doctor.
The instructions are provided solely for familiarization with " Betadine».

Betadine is one of the popular antiseptics used in surgery, gynecology, pediatrics and other areas of medicine. At what age can you use this medicine in children and what features of the application is important for parents to know?

Release form

In the pharmacy assortment you can find such Betadine:

The solution used for external processing. In such a brown clear liquid contains 10% active substance. The solution is poured into polyethylene bottles of different volumes - 30 ml, 120 ml and 1000 ml.
Ointment for external use. It is represented by a homogeneous mass of brown color, which has an unexpressed smell of iodine. One tube contains 20 g of ointment with a 10% content of the active ingredient.
Vaginal suppositories. They are distinguished by dark brown color, elongated shape and homogeneous structure. One package contains 7 or 14 suppositories.

Compound

The main ingredient in any form of Betadine is called povidone-iodine. In 1 ml of solution and 1 gram of ointment, it is contained in a dose of 100 mg. In one suppository, such a substance is contained in an amount of 200 mg.
Water, glycerol, Na hydroxide solution and disodium hydrogen phosphate are added to the liquid form. In addition, citric acid and nonoxynol 9 act as auxiliary components of the solution.
In Betadine ointment, in addition to povidone-iodine, purified water and Na bicarbonate, 4 types of macrogol (400, 1000, 1500 and 4000) are added.
In candles, macrogol 1000 is an additional component.

Operating principle

Betadine is classified as an antiseptic used topically and externally. Iodine, which is released from such a drug upon contact with the mucous membrane or skin surface, combines with microbial proteins, causing the bacteria to die within 15-60 seconds after treatment.

The drug has a bactericidal effect against many gram-positive and gram-negative microorganisms. Also, the tool affects fungi, protozoa and viruses. Only tuberculosis mycobacteria are resistant to it.

The principles of action of Betadine are very well shown in this video:

Indications

Betadine in solution is used for various purposes:

The patient's skin is treated with this preparation surgical treatment both before and after surgery.
Betadine is used in various medical procedures, such as injections, punctures, or biopsies. Lubricate the skin around the probe, catheter or drainage with this solution.
This is the medicine of surgeons and others medical workers applied to their hands before various procedures.
Betadine is advised to treat the hands of people who care for an infected patient.
Such a drug is also in demand for the treatment of patient care items.
The agent is used topically for infection of the nasopharynx (drip into the nose), as well as oral cavity(treat mucous with stomatitis, use for gargling).
Betadine is successfully used for various skin infections. It helps with viral lesions (for example, with chickenpox), with a fungal infection and purulent skin lesions.
Treatment with Betadine is prescribed for trophic ulcers, as well as for bedsores.

Betadine in the form of an ointment is in demand for purulent dermatitis, wounds, burns, trophic ulcers and other skin problems.

Betadine suppositories are prescribed for vaginosis, candidiasis, vaginitis and trichomonas infection, as well as for diagnostic or surgical procedures in the vagina.

At what age is it allowed to take?

Instructions for use of the ointment or solution prohibit the treatment with Betadine in children during the neonatal period.

The use of the drug in the first 4 weeks of life is permissible only if absolutely necessary and only after tests that determine the state of the thyroid gland.

For children older than a month, such forms of medicine can be used without fear, and in candles it is prescribed for girls over 8 years old.

Contraindications

Treatment with Betadine is prohibited:

With renal failure.
With thyroid adenoma.
With hypersensitivity to iodine.
With hyperthyroidism.
With dermatitis herpetiformis.

Side effects

If the patient has an increased sensitivity to iodine, treatment with Betadine will cause him to flush, itching and other local symptoms, after which the drug should be immediately discontinued. To make sure that there is no iodine intolerance, the first use of the drug should be trial - in a small amount on a small area of \u200b\u200bthe skin.

If Betadine is used in large quantities, treating a large area of the skin or mucous membrane, iodine from the drug will be absorbed, which can worsen thyroid function. The same side effect can be observed with a very long use of the drug.

Instructions for use and dosage

Liquid Betadine is used according to the following recommendations:

To treat the skin with Betadine solution, it is not required to dilute it. For the treatment of mucous membranes, drains, burn surfaces and in some other cases, the drug is diluted to a concentration of 0.1% to 5%.
Liquid Betadine must not be heated.
The medicine should not get into the eyes.
If Betadine comes into contact with blood when treating wounds, this will reduce its bactericidal effect.
The drug should not be used for animal or insect bites.
The surface treated with Betadine turns brown due to the formation of a film from which iodine is released. When it disappears, the effect of the drug ends. If necessary, such a film can be easily removed with water.

Ointment Betadine gently lubricate the damaged skin. This dosage form apply a thin layer 2 to 3 times a day. If required, the treated surface can be covered with an occlusive dressing. The ointment should not get on the mucous membrane of the eye, and the skin after lubrication, as in the case of treatment with a solution, acquires a brown tint, which can be easily eliminated by washing with plain water.

The Betadine suppository should be moistened with water and carefully inserted into the vagina (this form is especially carefully used in virgins). The medicine is used at night for 7-14 days.

Overdose

With very severe poisoning, laryngeal edema, deterioration of kidney function and blood circulation, as well as pulmonary edema, are possible. For treatment, the doctor prescribes symptomatic therapy.

Interaction with other drugs

Liquid Betadine must not be mixed with any disinfectant or antiseptic preparations, especially if they contain enzymes, mercury or alkali. The same restriction is provided for the ointment.

Terms of sale

The purchase of any form of the drug in a pharmacy is available without a prescription. The average price of 30 ml of solution is 160-170 rubles, tubes of ointment - 240-250 rubles, and packages of 7 suppositories - 350-400 rubles.

Storage conditions and shelf life

For storage, choose an unlit, dry place where there is no access to small child. liquid form should be stored at room temperature (below + 30 ° C), the optimal temperature range for storing the ointment is + 15 + 25 ° C, and for storing suppositories - + 5 + 15 ° C. The shelf life of the solution and ointment is 3 years, for suppositories - 5 years.

Content

There is a wide range of medicines that have a disinfecting effect. These include Betadine solution - an antiseptic that is used by gynecologists, surgeons and other doctors, the drug is successfully used for the treatment and prevention of many diseases. The main component of Betadine is iodine, so the product has a very wide spectrum of action aimed at combating bacteria, fungi and similar harmful organisms. According to reviews, the drug is distinguished by low toxicity, safety and high efficacy of the drug.

Betadine solution - instructions for use

A special topical solution with an antiseptic effect is Betadine. This medication combines iodine and polyvinylpyrrolidone, which binds it. The drug is also called povidone-iodine (generic international name). It has antiviral, disinfectant, disinfecting, bactericidal action.

Composition and form of release

Antiseptic medication is available in polyethylene bottles of 30, 120, 1000 ml. The kit includes a special dropper and a screw-on propylene stopper with first opening control. A container with a preparation of 30 and 120 ml is packed in a pack of cardboard, inside there is an instruction for the use of the medicine. The 1000 ml bottle is not packaged in a separate package, an annotation plus two labels is simply attached to it. Betadine solution is a dark brown liquid with the smell of iodine.

Due to the composition of Betadine, the maximum therapeutic effect is achieved. The tool contains the following active and additional components:

Substance	Quantity (per 100 ml of product)
Active element povidone-iodine
Disodium hydrogen phosphate
Nonoxynol 9
Anhydrous citric acid
Glycerol
Sodium hydroxide solution	10% solution (w/v) for pH adjustment
Purified water	Remaining volume

The mechanism of action of the drug

The disinfecting effect of the use of the drug Betadine is achieved with the help of iodine, which is released from the complex with polyvinylpyrrolidone. This occurs during the process of contact with the mucous membranes and human skin. Bottom line: the active element interacts with oxidizable groups of amino acids that are part of the structure of enzymes of microorganisms and proteins. The effect of the drug: the destruction of gram-positive, gram-negative microbes, some viruses, protozoa, spores and fungi.

After a long course of treatment of wounds, burns in large areas skin, in the body there is an increased content of iodine. The values decrease to normal one to two weeks after the last use of povidone-iodine. It is excreted exclusively through the kidneys. In patients with a healthy thyroid gland, an increase in the level of the active substance does not affect the hormonal background.

Indications for use

A drug antiseptic is sold without a prescription, but it can be taken only according to indications. Otherwise, you can aggravate the disease and worsen the state of health in general. The main pathologies for which Betadine is prescribed:

bedsores;
disinfection of the skin with microdamages, ulcers;
diabetic foot;
domestic burns, wounds;
antiseptic burns in traumatology and surgery;
bactericidal activity;
trophic ulcers;
disinfection of the skin area in which the catheter, probe or drainage system is installed;
therapy of bacterial, fungal, viral skin infections;
disinfection of the oral cavity in the presence of stomatitis and similar infections, during a dental operation;
Betadine solution is used in dermatology to avoid the development of a severe form of infection;
gynecology: treatment of mucous membranes before minor surgery (abortion, removal of erosion and polyps, insertion of an IUD);
obstetrics: antiseptics of the birth canal of a woman;
venereology: trichomoniasis, mycosis;
disinfection of parts of the mucous membranes, skin in the process of preparing for surgery or installing a dropper.

Betadine throat gargle

The drug is considered effective in infectious and viral infections affecting the throat, oral cavity of a person. Used for rinsing water solution iodine (ratio 1:10). Often, Betadine is used to treat such diseases:

angina (tonsillitis);
pharyngitis;
laryngitis, etc.

Betadine for burns

The drug for external use has a disinfecting effect on the following skin lesions:

Treatment of small burns (solution 10%).
Antiseptic for burn wounds.
Therapy of the skin damaged by fire is carried out with 1%, 5% or 10% povidone-iodine, which depends on the severity of the wounds.

In the process of treatment, you need to be as careful as possible, since the antiseptic treatment of large areas of severely damaged skin can lead to certain consequences:

negative reactions from the exchange of electrolytes (increase in the amount of sodium in the blood serum);
changes in osmolarity;
metabolic acidosis;
disorders in the work of the kidneys.

Treatment of wounds

By means of the drug Betadine, wounds of various kinds on the skin are often treated:

bedsores;
abrasions, scratches;
cut wounds;
treatment of skin with ulcers;
superficial dermatoses;
prevention of infection in wound surfaces.

Method of application and dosage

According to the instructions, the medicine can be used concentrated or mixed with water (do not dilute hot). When treating burns, wounds, preparing for surgery, the drug is diluted with isotonic sodium chloride solution. You can warm the medicine in your hands to room temperature. The tool is used no more than two or three times a day. Features of using Betadine:

Antisepsis of minor wounds, abrasions, scratches, small burns: 10% povidone-iodine undiluted twice a day.
Disinfection of the mucosa and skin surface before surgery: undiluted preparation twice in a couple of minutes.
Bactericidal effect against wounds, treatment of their complications: pure or 5% agent 2-3 times a day.
Acne, abscesses on the skin should be treated with a cotton swab dipped in concentrated 5% or 10% povidone-iodine (1 part of the drug and 2 parts of water).
Burns are treated with 1%, 5% or 10% preparation (1 part of the active substance in 10 parts of water), depending on the severity of the damage.
According to doctors, for the treatment of fungal or bacterial dermatitis, the skin must be treated with a 1% solution.
Disinfection before medical procedures (biopsy, blood sampling, infusion, puncture) is carried out by means of a concentrate for two minutes.
The consequences of invasions (droppers) are eliminated with a 5% or 10% remedy.
Rinse the mouth, throat with a diluted solution twice a day.
Washing of serous and articular cavities is carried out once a day with 0.1% or 1% agent.
To disinfect the skin of newborns, a 0.1% solution is used, navel treatment - 10%, for the prevention of conjunctivitis in babies - 2 drops of 2.5-5% medication in each eye.
In transplantology, ophthalmology, 1% -5% medication is used.
Povidone-iodine is one-time used for hygienic disinfection of the birth canal, minor gynecological operations, surgical treatment of cysts of parenchymal organs.
Herpes, papilloma are treated with a concentrated remedy. Hygienic treatment is performed twice a day.
Before surgery, the patient's body is wiped with a sponge soaked in Betadine (0.1-0.05%). Dilution of the solution: part 10% of the drug 100 and 200 parts of water.

special instructions

There are a number of special instructions that are prescribed in the instructions for the drug. If they are not adhered to, then side effects and complications of the pathology that is being treated may occur. Warnings and tips for using an antiseptic:

If a person has problems with the functioning of the thyroid gland, then it is allowed to use the remedy only under the supervision of a specialist.
Regular use of povidone-iodine should be cautious when the patient is ill with chronic renal failure.
On the site of the skin or mucous membrane, after the preparation has dried, a colored film is formed. This colored layer persists until all active iodine has left the body. When the film disappears, the drug stops its action.
Do not decontaminate bites of domestic / wild animals, insects.
Areas of skin and tissues after treatment with Betadine have a dark brown color. Discoloration is easily achieved with plain soap and water. If the stains are poorly removed, then you can use an ammonia solution.
It is necessary to ensure that no excess solution remains under the bedridden patient, otherwise this will lead to severe skin irritation.
If a disinfectant is ingested, the stomach is washed with diluted sodium thiosulfate (5%).

drug interaction

To avoid unpleasant side effects and not worsen your health, you need to know about the interaction of povidone-iodine with other medicines. The instructions say the following:

Betadine is incompatible with preparations containing mercury. This increases the risk of formation of alkaline mercury iodide.
The disinfectant may react with unsaturated organic compounds and proteins. This effect is compensated by increasing the dosage of povidone-iodine.
Patients who are being treated with lithium preparations are advised to refrain from prolonged therapy with a solution, especially on large affected surfaces.
The interaction of iodine with hydrogen peroxide, enzyme medicines (containing tauloridine and silver) can cause a mutual decrease in the effectiveness of drugs.

Betadine for children

The disinfectant has a slightly different effect on the skin of an infant than on the skin of an adult patient. An aseptic preparation cannot be used to treat premature babies and newborns (especially in the first month of life). The use of the drug is allowed only on the recommendation of a physician, and in the most extreme cases, after an examination of the thyroid gland.

Side effects

If the antiseptic is used illiterately, then unpleasant consequences may occur. When recommendations from the instructions are ignored, the following side effects are observed:

allergies (possible skin irritation, burning, itching, swelling, hyperemia);
hyperthyroidism - a chronic thyroid disease, which is characterized by an increase in the concentration of hormones in the blood (with long-term treatment with povidone-iodine);
osmolarity of blood serum;
electrolyte imbalance;
kidney failure;
rarely, an acute generalized reaction with hypotension and asthma attacks occurs.

Contraindications

Betadine has a number of contraindications that should not be ignored. Otherwise, health problems cannot be avoided. Main restrictions:

thyroid adenoma;
lactation period, pregnancy (2nd and 3rd trimester);
hyperthyroidism;
hypersensitivity to active and additional elements of the drug;
Duhring's dermatitis herpetiformis.

Terms of sale and storage

Povidone-iodine is available in pharmacies without a prescription. The solution is stored in a dark, dry place at an air temperature of no more than 30 degrees above zero. The shelf life of the drug is 3 years.

Betadine analogue

In pharmacy kiosks you can find an assortment of analogues of a disinfectant. most popular and effective means are considered:

Povidone-Iodine;
Yodiksol;
Iodinol;
Octasept;
Iodoflex;
Betiod.

Price Betadine

You can buy a broad-spectrum antiseptic at any pharmacy in Moscow and the region. The cost of the drug depends on the manufacturer, the form of release and the specific place of sale. Below is a table with an average approximate price for a disinfectant in different pharmacies in the country.

Video

Betadine - antiseptic and disinfectant medicinal product for local and external use.

Being released from the complex with polyvinylpyrrolidone upon contact with the skin and mucous membranes, iodine forms iodamines with bacterial cell proteins, coagulates them and causes the death of microorganisms.

On this page you will find all the information about Betadine: full instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Betadine. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antiseptic.

Terms of dispensing from pharmacies

Released without a prescription.

Prices

How much does Betadine cost? The average price in pharmacies is at the level of 450 rubles for candles, the ointment costs 250 rubles, and the solution can be bought for 300 rubles.

Release form and composition

Betadine is available in the following dosage forms:

10% ointment for external use in aluminum tubes of 20 g, one tube in a cardboard box. 1 g of Betadine ointment contains 100 mg of povidone-iodine and auxiliary components (macrogol - 400, 1000 and 4000, sodium bicarbonate and purified water);
10% solution for local and external use in dropper bottles of 30 and 120 ml (in cardboard boxes) or 1000 ml (without box). Main active substance the drug is povidone-iodine (100 mg in 1 ml of solution), and the auxiliary ones are glycerin, anhydrous citric acid, nonoxynol 9, sodium hydroxide 10%, disodium dihydrogen phosphate and purified water;
Vaginal suppositories dark brown torpedo-shaped. One suppository contains 200 mg of povidone-iodine and macrogol 1000 as an excipient. Candles are packed in blisters of 7 pieces, in a cardboard bundle 1 or 2 blisters.

Pharmacological effect

The drug is a complex compound of iodine and polyvinylpyrrolidone (PVP). PVP, an inert synthetic polymer, acts as a carrier. Accordingly, all pharmacological properties the drug is associated only with iodine, which belongs to the group of halogen antiseptics; The spectrum of action of iodine extends to Gram-positive and Gram-negative bacteria, fungi, protozoa, treponemas, viruses and acid-fast bacteria.

The bactericidal effect of iodine is explained by its strong oxidizing properties, it actively interacts with the amino acids of proteins, as a result of which the quaternary structure of the protein changes, its catalytic and enzymatic activity is lost. Basically, iodine disrupts the structures of bacterial transmembrane proteins and enzymes that do not have membrane protection. The concentration of active iodine in Betadine is 0.1-1%. Suppositories are made on a water-soluble basis and do not irritate the mucous membrane. At topical application there is almost no resorption of iodine from the mucous membrane.

Indications for use

Candles Betadine is used in the following cases:

(as part of combination therapy);
fungal infections of the vagina resulting from treatment with steroid and antibacterial drugs;
chronic and acute infections of the vagina of a specific and non-specific nature (vaginitis, bacterial, etc.);
treatment before and after transvaginal interventions during obstetric and diagnostic procedures.

Ointment Betadine has the following indications:

treatment of bacterial and fungal skin infections;
treatment of bedsores infected;
prevention of injury or infection of the skin (with small cuts and abrasions, minor burns and surgical interventions).

According to the instructions, Betadine solution is used in the following cases:

for disinfection of wounds and burns;
as first aid for contamination of mucous membranes or skin with infected material;
for antiseptic treatment of the operating room before gynecological, obstetric and surgical procedures and operations;
for disinfection of hands before taking a biopsy, performing punctures, injections, catheterization of the bladder.

Contraindications

The use of this remedy is contraindicated in such diseases and conditions:

subject to the simultaneous use of radioactive iodine;
at the age of a child under 1 year;
hyperthyroidism;
dermatitis herpetiformis Dühring;
thyroid adenoma;
with high sensitivity to iodine, as well as to other components of this remedy.

The use of the drug for newborns and premature babies is contraindicated. Use with caution when chronic inflammation skin, during pregnancy and lactation.

Instructions for candles

At acute vaginitis appoint 1 suppository 1-2 times / day for 7 days.
At chronic and subacute vaginitis- 1 suppository 1 time / day at bedtime for 14 days, if necessary - longer.

Instructions for ointment

Apply only externally. On the affected surface of the skin, the ointment is applied in a thin layer 2-3 times / day. Can be used under occlusive dressings.

Instructions for the solution

For the treatment of the skin and mucous membranes, the Betadine solution is used undiluted for lubrication, washing, or as a wet compress.

For use in drainage systems, a 10% solution is diluted 10 to 100 times. The solution is prepared immediately before use, diluted solutions are not stored.

Side effects

The following side effects of suppositories and other forms of release of the drug are noted:

local manifestations of an allergic reaction to iodine in the form of redness, rash, itching;
vaginal dysbacteriosis (with prolonged use of suppositories);
thyrotoxicosis (with a hereditary predisposition).

Overdose

In case of an overdose, the following symptoms may be observed:

Dermatitis and redness of the skin.
Diarrhea.
Impaired renal function.
Intestinal disorders.
Metallic taste in the mouth.
Eye irritation and swelling.
Burning in mouth and throat.
Pulmonary swelling.
Hypernatremia.

special instructions

The use of Betadine may reduce the absorption of iodine by the thyroid gland and distort the results of diagnostic tests (thyroid scintigraphy, determination of protein-bound iodine, measurements using radioactive iodine) or interfere with iodine therapy of the thyroid gland. After using the drug Betadine before carrying out the listed procedures, a period should be maintained, the duration of which should be determined by the doctor.
Prolonged use of Betadine can lead to absorption through the skin and mucous membranes of a significant amount of iodine. Therefore, after prolonged use of suppositories, it is necessary to perform a study of thyroid function.
The use of Betadine suppositories in childhood before reaching puberty is contraindicated. The doctor should decide on the possibility of using the drug in virgins and carry out at least the first administration of the suppository.
Contamination with povidone-iodine can cause false-positive results in some diagnostic tests, such as fecal occult blood or urine glucose.
Accidental ingestion of suppositories by children should be avoided.

drug interaction

It is forbidden to use vaginal suppositories Betadine along with other antiseptics: alcohol, salicylic acid, hydrogen peroxide, etc. So the risk of getting a burn on the membranes of the genital organs increases significantly, the effectiveness of the use of both drugs decreases. The complex use of suppositories with preparations that contain taurolidine, silver, mercury, lithium and enzymes is unacceptable.